calcium pantothenate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2055 79-83-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • calcium pantothenate
  • pantothenic acid
  • (+)-Pantothenic acid
  • D-Pantothenic acid
  • Vitamin B5
A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
  • Molecular weight: 219.24
  • Formula: C9H17NO5
  • CLOGP: -1.49
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 106.86
  • ALOGS: -0.56
  • ROTB: 6
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 41
kinase-selectivity-class ACVRL1,AXL,BRAF,CDK9,GRK2,MAP2K6,PIK3CD,TEK,TGFBR1 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hand deformity 113.95 9.86 8 44305 296354 90287780
Pemphigus 111.97 9.86 14 44299 326850 90257284
Diarrhoea 100.71 9.86 793 43520 938397 89645737
Glossodynia 98.39 9.86 19 44294 321760 90262374
Contraindicated product administered 97.68 9.86 19 44294 320120 90264014
Systemic lupus erythematosus 97.58 9.86 28 44285 361868 90222266
Product dose omission issue 95.83 9.86 337 43976 291350 90292784
Infusion related reaction 95.75 9.86 42 44271 416738 90167396
Off label use 77.02 9.86 279 44034 1101973 89482161
Treatment failure 75.73 9.86 27 44286 303901 90280233
Fall 74.75 9.86 446 43867 481364 90102770
Anti-cyclic citrullinated peptide antibody positive 74.32 9.86 13 44300 236420 90347714
Maternal exposure during pregnancy 74.07 9.86 42 44271 360021 90224113
Unevaluable event 73.57 9.86 111 44202 54737 90529397
Pericarditis 72.61 9.86 21 44292 270130 90314004
Synovitis 71.44 9.86 36 44277 329716 90254418
Wound 70.39 9.86 30 44283 302950 90281184
Helicobacter infection 70.16 9.86 13 44300 226837 90357297
Product use issue 70.01 9.86 37 44276 329882 90254252
Device expulsion 68.49 9.86 92 44221 40794 90543340
Muscle injury 61.86 9.86 7 44306 176647 90407487
Hepatic enzyme increased 61.04 9.86 52 44261 360684 90223450
Duodenal ulcer perforation 58.01 9.86 18 44295 221270 90362864
Lower respiratory tract infection 57.93 9.86 25 44288 250634 90333500
Fatigue 57.75 9.86 836 43477 1153187 89430947
Full blood count decreased 56.26 9.86 71 44242 29618 90554516
Arthropathy 53.63 9.86 60 44253 366182 90217952
Muscle spasms 52.49 9.86 253 44060 251630 90332504
Toxicity to various agents 51.81 9.86 39 44274 287807 90296327
Product use in unapproved indication 51.55 9.86 53 44260 336183 90247951
Deep vein thrombosis 51.26 9.86 128 44185 91492 90492642
Folliculitis 51.14 9.86 18 44295 204335 90379799
Intentional product use issue 51.13 9.86 21 44292 216871 90367263
Device dislocation 49.94 9.86 69 44244 31413 90552721
Feeling abnormal 49.58 9.86 187 44126 167048 90417086
Therapy cessation 46.52 9.86 72 44241 36289 90547845
Neuropathy peripheral 46.41 9.86 160 44153 136810 90447324
Flatulence 46.20 9.86 77 44236 41290 90542844
Sleep disorder due to general medical condition, insomnia type 45.30 9.86 5 44308 128689 90455445
Nausea 44.73 9.86 776 43537 1109540 89474594
Irritable bowel syndrome 44.37 9.86 23 44290 207425 90376709
Type 2 diabetes mellitus 42.78 9.86 23 44290 203221 90380913
Rheumatoid factor positive 41.46 9.86 16 44297 171634 90412500
General physical health deterioration 41.08 9.86 69 44244 355046 90229088
Liver injury 41.03 9.86 16 44297 170551 90413583
Dizziness 40.87 9.86 454 43859 588830 89995304
Haemoglobin decreased 40.70 9.86 172 44141 161784 90422350
Drug ineffective 38.95 9.86 462 43851 1383836 89200298
Constipation 38.04 9.86 251 44062 280144 90303990
Plasma cell myeloma 37.81 9.86 70 44243 40758 90543376
Dehydration 37.42 9.86 191 44122 194256 90389878
Drug hypersensitivity 37.30 9.86 110 44203 463499 90120635
Discomfort 36.89 9.86 48 44265 274287 90309847
Drug intolerance 36.88 9.86 105 44208 447486 90136648
Joint swelling 36.58 9.86 125 44188 503175 90080959
C-reactive protein abnormal 35.93 9.86 9 44304 127420 90456714
Asthenia 35.08 9.86 407 43906 533344 90050790
Impaired healing 34.66 9.86 38 44275 234161 90349973
Ill-defined disorder 33.32 9.86 25 44288 184866 90399268
Blister 32.88 9.86 46 44267 254952 90329182
Psoriasis 31.90 9.86 150 44163 147604 90436530
C-reactive protein increased 30.83 9.86 26 44287 181363 90402771
Hypersensitivity 30.34 9.86 117 44196 454560 90129574
Back pain 30.08 9.86 261 44052 316914 90267220
Fibromyalgia 29.94 9.86 34 44279 206235 90377899
Intentional overdose 29.82 9.86 5 44308 93829 90490305
Pneumonia 29.68 9.86 457 43856 637602 89946532
Lip dry 28.71 9.86 7 44306 100948 90483186
Urinary tract infection 28.20 9.86 250 44063 305382 90278752
Exposure during pregnancy 27.85 9.86 46 44267 238364 90345770
Pulmonary embolism 27.65 9.86 132 44181 130688 90453446
Hot flush 27.07 9.86 77 44236 59411 90524723
Headache 26.48 9.86 579 43734 862167 89721967
Joint range of motion decreased 26.21 9.86 17 44296 135626 90448508
Memory impairment 25.19 9.86 174 44139 197070 90387064
Infection 24.90 9.86 92 44221 362002 90222132
Pelvic pain 24.87 9.86 34 44279 15323 90568811
Asthma 24.50 9.86 51 44262 242109 90342025
Injection site pain 24.45 9.86 157 44156 173542 90410592
Injection site haemorrhage 24.30 9.86 47 44266 28271 90555863
Injection site erythema 24.26 9.86 104 44209 98398 90485736
Paraesthesia 24.25 9.86 207 44106 250119 90334015
Laboratory test abnormal 23.95 9.86 59 44254 41795 90542339
Dyspnoea 23.86 9.86 581 43732 880374 89703760
Therapeutic product effect decreased 23.67 9.86 64 44249 277507 90306627
COVID-19 23.25 9.86 29 44284 168814 90415320
Eye swelling 23.08 9.86 47 44266 29339 90554795
Influenza like illness 22.93 9.86 89 44224 80522 90503612
Rheumatic fever 22.48 9.86 25 44288 153096 90431038
Alopecia 22.35 9.86 146 44167 494925 90089209
Prescribed overdose 22.12 9.86 10 44303 97615 90486519
Tremor 21.90 9.86 139 44174 153034 90431100
Mucous stools 21.54 9.86 19 44294 5252 90578882
Hip fracture 21.50 9.86 49 44264 33028 90551106
Depression 21.42 9.86 233 44080 300368 90283766
Mobility decreased 21.23 9.86 58 44255 250676 90333458
Blood potassium decreased 20.97 9.86 61 44252 47666 90536468
Obesity 20.69 9.86 13 44300 105494 90478640
Gastrointestinal disorder 20.54 9.86 61 44252 256626 90327508
Hypercholesterolaemia 20.38 9.86 12 44301 100880 90483254
Therapeutic product effect incomplete 20.32 9.86 40 44273 193856 90390278
Condition aggravated 20.19 9.86 190 44123 595355 89988779
Vaginal haemorrhage 19.97 9.86 46 44267 31225 90552909
Rectal fissure 19.90 9.86 9 44304 765 90583369
Balance disorder 19.82 9.86 97 44216 96983 90487151
Skin discolouration 19.81 9.86 57 44256 44258 90539876
Overdose 19.78 9.86 29 44284 157680 90426454
Hypervolaemia 19.62 9.86 47 44266 32710 90551424
Pulmonary arterial hypertension 19.53 9.86 41 44272 26146 90557988
Multiple sclerosis relapse 19.39 9.86 63 44250 52242 90531892
Nasal congestion 18.97 9.86 86 44227 83328 90500806
Atrial fibrillation 18.94 9.86 121 44192 133490 90450644
Swollen joint count increased 18.82 9.86 16 44297 111190 90472944
White blood cell count decreased 18.79 9.86 143 44170 166966 90417168
Bursitis 18.77 9.86 22 44291 131632 90452502
Grip strength decreased 18.72 9.86 11 44302 92565 90491569
Gastrooesophageal reflux disease 18.51 9.86 142 44171 166195 90417939
Chills 18.39 9.86 119 44194 131862 90452272
Pulmonary hypertension 18.34 9.86 54 44259 42469 90541665
Hypoaesthesia 18.16 9.86 234 44079 313976 90270158
Thrombosis 17.77 9.86 77 44236 73174 90510960
Illness 17.65 9.86 9 44304 81960 90502174
Cardiac failure congestive 17.63 9.86 95 44218 98599 90485535
Feeding intolerance 17.59 9.86 9 44304 1005 90583129
Gastrointestinal ulcer 17.59 9.86 13 44300 2798 90581336
Dysgeusia 17.44 9.86 61 44252 52499 90531635
Wheezing 17.35 9.86 59 44254 238021 90346113
Dry skin 17.27 9.86 87 44226 87986 90496148
Facet joint syndrome 16.84 9.86 14 44299 98375 90485759
Suicide attempt 16.65 9.86 8 44305 75391 90508743
Fluid retention 16.56 9.86 86 44227 88005 90496129
Pulmonary fibrosis 16.39 9.86 17 44296 107486 90476648
Vision blurred 16.33 9.86 101 44212 110192 90473942
Product complaint 16.25 9.86 26 44287 13474 90570660
Blood cholesterol increased 16.23 9.86 50 44263 207962 90376172
Dyspnoea exertional 16.04 9.86 74 44239 72214 90511920
Hypoxia 15.98 9.86 74 44239 72325 90511809
Drug interaction 15.45 9.86 76 44237 276377 90307757
Flushing 15.01 9.86 84 44229 88407 90495727
Chest discomfort 14.77 9.86 117 44196 138248 90445886
Breast cancer stage III 14.47 9.86 12 44301 84435 90499699
Pleural effusion 14.41 9.86 99 44214 111892 90472242
Body height decreased 14.36 9.86 23 44290 11926 90572208
Autoimmune disorder 14.31 9.86 10 44303 76734 90507400
Administration site swelling 14.31 9.86 9 44304 1490 90582644
Platelet count decreased 14.17 9.86 115 44198 136854 90447280
International normalised ratio increased 14.08 9.86 53 44260 47263 90536871
Lung disorder 13.98 9.86 33 44280 149850 90434284
Tooth disorder 13.91 9.86 40 44273 31050 90553084
Dislocation of vertebra 13.87 9.86 5 44308 55963 90528171
Hypertension 13.82 9.86 150 44163 457382 90126752
Cellulitis 13.74 9.86 84 44229 91253 90492881
Gallbladder disorder 13.61 9.86 30 44283 19773 90564361
Injection site mass 13.56 9.86 32 44281 22058 90562076
Hospice care 13.52 9.86 20 44293 9684 90574450
Myalgia 13.52 9.86 138 44175 174987 90409147
Deep vein thrombosis postoperative 13.50 9.86 9 44304 70800 90513334
Abdominal discomfort 13.43 9.86 159 44154 477169 90106965
Cholangitis sclerosing 13.29 9.86 10 44303 2211 90581923
Weight decreased 13.24 9.86 260 44053 379650 90204484
Plasma cell myeloma recurrent 12.97 9.86 13 44300 4215 90579919
Intestinal dilatation 12.94 9.86 10 44303 2300 90581834
Taste disorder 12.92 9.86 62 44251 61484 90522650
Heavy menstrual bleeding 12.89 9.86 30 44283 20500 90563634
Abdominal pain 12.86 9.86 268 44045 395453 90188681
Fistula 12.83 9.86 22 44291 12067 90572067
Intentional product misuse 12.74 9.86 15 44298 89589 90494545
Bone erosion 12.70 9.86 5 44308 53016 90531118
Bone pain 12.70 9.86 62 44251 61921 90522213
Oesophageal ulcer 12.61 9.86 14 44299 5105 90579029
Cardiac pacemaker insertion 12.52 9.86 13 44300 4394 90579740
Adverse event 12.49 9.86 24 44289 117394 90466740
Pollakiuria 12.45 9.86 40 44273 32965 90551169
Hypophagia 12.18 9.86 42 44271 35895 90548239
Abdominal distension 12.11 9.86 107 44206 130494 90453640
Injection site bruising 11.94 9.86 54 44259 52253 90531881
Anaemia 11.81 9.86 240 44073 352562 90231572
Ageusia 11.79 9.86 25 44288 16051 90568083
Ovarian cyst 11.64 9.86 26 44287 17292 90566842
Multiple allergies 11.63 9.86 24 44289 15122 90569012
Anal incontinence 11.63 9.86 25 44288 16205 90567929
Red blood cell count decreased 11.45 9.86 49 44264 46302 90537832
Lethargy 11.43 9.86 61 44252 63078 90521056
Intestinal obstruction 11.39 9.86 42 44271 37089 90547045
Lupus vulgaris 11.21 9.86 4 44309 45055 90539079
Restless legs syndrome 11.13 9.86 30 44283 22440 90561694
Adjustment disorder with depressed mood 11.11 9.86 7 44306 56746 90527388
Swelling face 11.11 9.86 73 44240 81279 90502855
Procedural complication 11.04 9.86 14 44299 5864 90578270
Coeliac disease 11.03 9.86 4 44309 44606 90539528
Blood culture positive 11.02 9.86 13 44300 5059 90579075
Swelling 10.87 9.86 142 44171 418916 90165218
Infusion site nodule 10.85 9.86 8 44305 1715 90582419
Multiple sclerosis 10.74 9.86 34 44279 27806 90556328
Laryngeal pain 10.73 9.86 12 44301 4410 90579724
Musculoskeletal stiffness 10.72 9.86 93 44220 296439 90287695
Complication associated with device 10.69 9.86 27 44286 19422 90564712
Hip arthroplasty 10.58 9.86 13 44300 76195 90507939
Pain in jaw 10.55 9.86 49 44264 47936 90536198
Oedema peripheral 10.55 9.86 181 44132 257734 90326400
Disease complication 10.49 9.86 11 44302 3761 90580373
Injection site atrophy 10.47 9.86 6 44307 838 90583296
Endometriosis 10.37 9.86 14 44299 6234 90577900
Pain in extremity 10.36 9.86 291 44022 450238 90133896
Retinitis 10.30 9.86 3 44310 38455 90545679
Liver disorder 10.30 9.86 28 44285 121241 90462893
Epistaxis 10.22 9.86 74 44239 85051 90499083
Haematocrit decreased 10.17 9.86 44 44269 41788 90542346
Hepatic function abnormal 10.09 9.86 5 44308 46283 90537851
International normalised ratio decreased 10.08 9.86 12 44301 4712 90579422
Intermenstrual bleeding 10.07 9.86 17 44296 9206 90574928
Therapy change 9.98 9.86 16 44297 8306 90575828
Peripheral venous disease 9.97 9.86 16 44297 83905 90500229
Burning sensation 9.96 9.86 59 44254 63393 90520741
Pulmonary oedema 9.92 9.86 58 44255 62022 90522112
Occult blood positive 9.90 9.86 11 44302 4012 90580122
Upper limb fracture 9.88 9.86 28 44285 21550 90562584

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 126.24 12.29 124 26008 638211 41956992
Fractional exhaled nitric oxide increased 120.34 12.29 43 26089 1566 42593637
Myoglobin blood increased 94.96 12.29 46 26086 3636 42591567
Sensation of foreign body 89.76 12.29 44 26088 3569 42591634
Plantar fasciitis 87.24 12.29 41 26091 3029 42592174
Brain natriuretic peptide increased 73.69 12.29 48 26084 6722 42588481
Exostosis 71.47 12.29 44 26088 5587 42589616
Product use in unapproved indication 70.03 12.29 14 26118 184442 42410761
Cardiac disorder 60.45 12.29 108 26024 48824 42546379
Fatigue 53.54 12.29 452 25680 435189 42160014
Plasma cell myeloma 50.02 12.29 98 26034 47480 42547723
Dysphonia 49.00 12.29 73 26059 28377 42566826
Muscle spasms 48.56 12.29 139 25993 85905 42509298
Increased upper airway secretion 45.82 12.29 25 26107 2531 42592672
Drug interaction 44.70 12.29 59 26073 266940 42328263
Gait spastic 43.71 12.29 20 26112 1389 42593814
Needle fatigue 43.32 12.29 19 26113 1194 42594009
Full blood count decreased 40.15 12.29 56 26076 20504 42574699
Relapsing-remitting multiple sclerosis 39.52 12.29 19 26113 1476 42593727
Completed suicide 39.47 12.29 6 26126 96459 42498744
Fall 38.66 12.29 261 25871 234259 42360944
Drug ineffective 38.60 12.29 228 25904 629969 41965234
Secretion discharge 38.11 12.29 34 26098 7601 42587602
Product dose omission issue 37.23 12.29 190 25942 154175 42441028
Asthenia 35.78 12.29 294 25838 280499 42314704
Laboratory test abnormal 35.40 12.29 56 26076 22922 42572281
Toxicity to various agents 35 12.29 54 26078 229082 42366121
Foreign body in throat 34.68 12.29 13 26119 543 42594660
Multiple sclerosis relapse 34.25 12.29 43 26089 14221 42580982
Muscle spasticity 33.30 12.29 30 26102 6792 42588411
Diarrhoea 31.44 12.29 425 25707 460424 42134779
Dyspnoea exertional 31.22 12.29 84 26048 50064 42545139
Hypertonic bladder 31.22 12.29 19 26113 2362 42592841
COVID-19 29.82 12.29 17 26115 115931 42479272
White blood cell count decreased 28.81 12.29 139 25993 110257 42484946
Obstructive airways disorder 28.47 12.29 53 26079 24706 42570497
Monoparesis 27.44 12.29 19 26113 2941 42592262
Dizziness 27.05 12.29 252 25880 249002 42346201
Coronary artery disease 26.70 12.29 83 26049 53637 42541566
Pneumothorax 26.58 12.29 50 26082 23493 42571710
Memory impairment 26.27 12.29 79 26053 50143 42545060
Intentional product use issue 26.11 12.29 6 26126 71827 42523376
Micturition urgency 25.64 12.29 34 26098 11864 42583339
Adverse drug reaction 24.62 12.29 64 26068 37370 42557833
Viral infection 22.04 12.29 45 26087 22438 42572765
Hypoaesthesia 21.62 12.29 94 26038 71369 42523834
Treatment failure 21.28 12.29 6 26126 62618 42532585
Overdose 21.15 12.29 20 26112 105244 42489959
Central nervous system lesion 20.96 12.29 25 26107 7845 42587358
Balance disorder 20.42 12.29 70 26062 47575 42547628
Nasopharyngitis 19.95 12.29 103 26029 83893 42511310
Atrial fibrillation 19.83 12.29 150 25982 139443 42455760
Psoriasis 18.76 12.29 69 26063 48535 42546668
Drug ineffective for unapproved indication 18.58 12.29 3 26129 46160 42549043
Thrombosis 18.39 12.29 87 26045 68424 42526779
Interstitial lung disease 18.12 12.29 13 26119 78449 42516754
Wheezing 18.07 12.29 74 26058 54707 42540496
Cytokine release syndrome 17.69 12.29 3 26129 44524 42550679
General physical health deterioration 17.52 12.29 42 26090 151204 42443999
Hepatic function abnormal 17.41 12.29 5 26127 51562 42543641
Pneumonia 16.49 12.29 356 25776 421793 42173410
Sinusitis 15.69 12.29 64 26068 47228 42547975
Neuropathy peripheral 15.34 12.29 111 26021 101742 42493461
Coma 15.03 12.29 7 26125 53547 42541656
Influenza 14.59 12.29 76 26056 62099 42533104
Pollakiuria 14.31 12.29 38 26094 22467 42572736
Nocturia 14.01 12.29 26 26106 12086 42583117
Product use issue 13.82 12.29 16 26116 76735 42518468
Peripheral swelling 13.37 12.29 98 26034 90172 42505031
Small intestinal obstruction 13.15 12.29 31 26101 17030 42578173
Leukopenia 13.01 12.29 16 26116 74730 42520473
Suicide attempt 12.98 12.29 6 26126 46094 42549109
Influenza like illness 12.96 12.29 46 26086 31794 42563409
Rash 12.94 12.29 240 25892 276714 42318489
Haemoglobin decreased 12.89 12.29 131 26001 132340 42462863
Unevaluable event 12.67 12.29 48 26084 34240 42560963
Drug reaction with eosinophilia and systemic symptoms 12.60 12.29 5 26127 42070 42553133
Febrile neutropenia 12.47 12.29 65 26067 185638 42409565
Mental status changes 12.43 12.29 55 26077 42060 42553143
Dyspnoea 12.42 12.29 357 25775 442264 42152939
Constipation 12.39 12.29 153 25979 162138 42433065

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 152.91 9.95 337 55996 1499848 109033118
Completed suicide 96.50 9.95 7 56326 242374 110290592
Product dose omission issue 93.09 9.95 367 55966 321415 110211551
Fall 88.12 9.95 567 55766 602915 109930051
Product use in unapproved indication 84.13 9.95 63 56270 447314 110085652
Hand deformity 79.76 9.95 9 56324 218497 110314469
Fractional exhaled nitric oxide increased 79.08 9.95 25 56308 751 110532215
Toxicity to various agents 77.83 9.95 78 56255 480477 110052489
Treatment failure 76.60 9.95 23 56310 277211 110255755
Device expulsion 75.84 9.95 86 56247 30805 110502161
Infusion related reaction 73.83 9.95 52 56281 381110 110151856
Contraindicated product administered 73.48 9.95 18 56315 248249 110284717
Diarrhoea 69.14 9.95 884 55449 1138621 109394345
Systemic lupus erythematosus 66.90 9.95 23 56310 254315 110278651
Pemphigus 66.61 9.95 14 56319 214556 110318410
Drug ineffective 65.65 9.95 480 55853 1520060 109012906
Plasma cell myeloma 65.30 9.95 116 56217 62820 110470146
Dizziness 61.75 9.95 584 55749 697609 109835357
Intentional product use issue 60.88 9.95 25 56308 247881 110285085
Fatigue 59.07 9.95 907 55426 1215051 109317915
Glossodynia 58.52 9.95 20 56313 221984 110310982
Product use issue 58.43 9.95 44 56289 311651 110221315
Synovitis 56.29 9.95 35 56298 274057 110258909
Asthenia 55.39 9.95 565 55768 688434 109844532
Drug interaction 55.15 9.95 107 56226 500076 110032890
Anti-cyclic citrullinated peptide antibody positive 54.22 9.95 13 56320 181971 110350995
Deep vein thrombosis 52.69 9.95 174 56159 139713 110393253
Helicobacter infection 52.25 9.95 14 56319 181863 110351103
COVID-19 52.14 9.95 30 56303 245030 110287936
Dehydration 49.89 9.95 277 56056 279234 110253732
Needle fatigue 49.37 9.95 20 56313 1244 110531722
Gait spastic 48.70 9.95 21 56312 1528 110531438
Muscle injury 48.47 9.95 7 56326 140800 110392166
Therapy cessation 48.24 9.95 84 56249 44773 110488193
Hepatic enzyme increased 47.57 9.95 56 56277 320836 110212130
Brain natriuretic peptide increased 47.53 9.95 42 56291 11167 110521799
Muscle spasms 46.58 9.95 271 56062 277886 110255080
Multiple sclerosis relapse 46.31 9.95 88 56245 50152 110482814
Myoglobin blood increased 45.96 9.95 28 56305 4204 110528762
Relapsing-remitting multiple sclerosis 45.77 9.95 22 56311 2060 110530906
Haemoglobin decreased 45.39 9.95 248 56085 248479 110284487
Full blood count decreased 45.29 9.95 68 56265 32031 110500935
Intentional overdose 44.66 9.95 7 56326 132494 110400472
General physical health deterioration 44.29 9.95 94 56239 425201 110107765
Maternal exposure during pregnancy 44.00 9.95 39 56294 254844 110278122
Lower respiratory tract infection 43.43 9.95 36 56297 243070 110289896
Increased upper airway secretion 42.90 9.95 29 56304 5203 110527763
Dyspnoea 42.46 9.95 795 55538 1106077 109426889
Dyspnoea exertional 42.41 9.95 133 56200 103927 110429039
Unevaluable event 41.90 9.95 93 56240 59134 110473832
Device dislocation 41.68 9.95 65 56268 31639 110501327
C-reactive protein abnormal 41.21 9.95 8 56325 129687 110403279
Plantar fasciitis 41.17 9.95 28 56305 5073 110527893
Pericarditis 40.96 9.95 31 56302 219083 110313883
Duodenal ulcer perforation 40.37 9.95 20 56313 177680 110355286
Joint swelling 38.90 9.95 107 56226 442738 110090228
Cardiac disorder 38.28 9.95 105 56228 76175 110456791
Sensation of foreign body 38.12 9.95 32 56301 7943 110525023
Feeling abnormal 36.96 9.95 186 56147 180525 110352441
Sleep disorder due to general medical condition, insomnia type 36.95 9.95 5 56328 105638 110427328
Irritable bowel syndrome 36.53 9.95 19 56314 164196 110368770
Folliculitis 36.41 9.95 20 56313 167633 110365333
Overdose 34.43 9.95 41 56292 233753 110299213
Drug hypersensitivity 34.00 9.95 118 56215 453972 110078994
Arthropathy 33.89 9.95 59 56274 287463 110245503
C-reactive protein increased 32.32 9.95 38 56295 217881 110315085
Micturition urgency 31.75 9.95 44 56289 19276 110513690
Hypervolaemia 30.95 9.95 74 56259 49386 110483580
Pneumonia 30.60 9.95 621 55712 876093 109656873
Wound 30.55 9.95 45 56288 234392 110298574
Lip dry 30.10 9.95 7 56326 100076 110432890
Memory impairment 29.84 9.95 187 56146 196757 110336209
Nausea 29.65 9.95 831 55502 1234859 109298107
Type 2 diabetes mellitus 29.54 9.95 28 56305 177204 110355762
Drug intolerance 29.52 9.95 107 56226 406405 110126561
Foreign body in throat 28.86 9.95 13 56320 1050 110531916
Liver injury 28.47 9.95 21 56312 150392 110382574
Fluid retention 28.38 9.95 109 56224 94198 110438768
Ill-defined disorder 28.29 9.95 23 56310 156830 110376136
Rheumatoid factor positive 28.15 9.95 16 56317 131624 110401342
Mental status changes 28.04 9.95 94 56239 76028 110456938
Hospice care 27.73 9.95 33 56300 12440 110520526
Mobility decreased 27.72 9.95 49 56284 237373 110295593
Flatulence 27.38 9.95 73 56260 52076 110480890
Fibromyalgia 27.33 9.95 28 56305 170881 110362085
Intentional product misuse 27.23 9.95 17 56316 132887 110400079
Illness 26.25 9.95 5 56328 82166 110450800
Monoparesis 25.41 9.95 20 56313 4533 110528433
Pollakiuria 25.40 9.95 64 56269 44131 110488835
Cytokine release syndrome 25.38 9.95 3 56330 70303 110462663
Cardiac failure congestive 25.17 9.95 147 56186 150853 110382113
Atrial fibrillation 24.85 9.95 201 56132 229441 110303525
Hypertonic bladder 24.77 9.95 21 56312 5281 110527685
Hip fracture 24.64 9.95 55 56278 35096 110497870
Pulmonary embolism 24.45 9.95 190 56143 214284 110318682
Influenza like illness 24.04 9.95 99 56234 88313 110444653
Haematocrit decreased 23.78 9.95 81 56252 66036 110466930
Suicide attempt 22.93 9.95 12 56321 103382 110429584
Pelvic pain 22.81 9.95 34 56299 15908 110517058
International normalised ratio increased 22.68 9.95 96 56237 86676 110446290
Small intestinal obstruction 22.13 9.95 50 56283 32163 110500803
Hypoaesthesia 22.06 9.95 251 56082 313972 110218994
Rectal fissure 21.90 9.95 11 56322 1133 110531833
Pulmonary arterial hypertension 21.76 9.95 50 56283 32518 110500448
Viral infection 21.72 9.95 68 56265 53071 110479895
Blister 21.42 9.95 53 56280 227323 110305643
Eye swelling 21.27 9.95 50 56283 32998 110499968
Therapeutic product effect incomplete 21.22 9.95 52 56281 223753 110309213
Balance disorder 21.09 9.95 116 56217 116444 110416522
Pulmonary hypertension 21.06 9.95 69 56264 55151 110477815
Discomfort 21.06 9.95 49 56284 214658 110318308
Blood potassium decreased 20.98 9.95 68 56265 54046 110478920
Exposure during pregnancy 20.98 9.95 33 56300 167391 110365575
Depression 20.73 9.95 250 56083 317085 110215881
Injection site erythema 20.72 9.95 99 56234 94077 110438889
Hypersensitivity 20.60 9.95 121 56212 403877 110129089
Joint range of motion decreased 20.59 9.95 19 56314 121813 110411153
Hepatic function abnormal 20.35 9.95 10 56323 89285 110443681
Tremor 20.27 9.95 174 56159 202058 110330908
Hypoxia 20.25 9.95 124 56209 129391 110403575
Thrombosis 20.24 9.95 109 56224 108553 110424413
Obesity 19.97 9.95 17 56316 113334 110419632
Injection site pain 19.93 9.95 157 56176 177765 110355201
Infection 19.81 9.95 106 56227 362094 110170872
White blood cell count decreased 19.75 9.95 191 56142 229199 110303767
Depressed level of consciousness 19.58 9.95 17 56316 112261 110420705
Condition aggravated 19.32 9.95 261 56072 734575 109798391
Cellulitis 19.29 9.95 120 56213 125896 110407070
Injection site haemorrhage 19.16 9.95 48 56285 32980 110499986
Pleural effusion 18.92 9.95 155 56178 177554 110355412
Bursitis 18.89 9.95 23 56310 129895 110403071
Therapeutic response decreased 18.88 9.95 13 56320 96486 110436480
Weight decreased 18.83 9.95 339 55994 467718 110065248
Urinary tract infection 18.74 9.95 251 56082 326031 110206935
Headache 18.54 9.95 584 55749 881793 109651173
Impaired healing 18.42 9.95 46 56287 196671 110336295
Back pain 18.35 9.95 278 56055 370718 110162248
Complication associated with device 18.30 9.95 35 56298 20038 110512928
Prescribed overdose 18.22 9.95 11 56322 87570 110445396
Chills 18.07 9.95 162 56171 190418 110342548
Constipation 18.05 9.95 269 56064 357517 110175449
Dysgeusia 17.96 9.95 77 56256 69908 110463058
Facet joint syndrome 17.70 9.95 14 56319 96814 110436152
Anxiety 17.62 9.95 260 56073 344818 110188148
Product complaint 17.47 9.95 28 56305 13944 110519022
Drug ineffective for unapproved indication 17.42 9.95 16 56317 102822 110430144
Oedema peripheral 17.32 9.95 249 56084 328411 110204555
Agranulocytosis 17.27 9.95 5 56328 61755 110471211
Nasal congestion 17.24 9.95 97 56236 98185 110434781
Nocturia 17.21 9.95 31 56302 16959 110516007
Pneumothorax 17.13 9.95 48 56285 35237 110497729
Flushing 16.83 9.95 101 56232 104635 110428331
Grip strength decreased 16.78 9.95 10 56323 80164 110452802
Gastrointestinal disorder 16.69 9.95 65 56268 241887 110291079
Cholestasis 16.67 9.95 6 56327 64512 110468454
Central nervous system lesion 16.56 9.95 29 56304 15524 110517442
Hypertension 16.53 9.95 173 56160 509911 110023055
Erectile dysfunction 16.48 9.95 32 56301 18524 110514442
Vaginal haemorrhage 16.21 9.95 38 56295 25036 110507930
Gastrointestinal ulcer 16.17 9.95 15 56318 4245 110528721
Drug reaction with eosinophilia and systemic symptoms 16.14 9.95 11 56322 82084 110450882
Dysphonia 16.11 9.95 79 56254 75850 110457116
Chest discomfort 16.09 9.95 147 56186 173701 110359265
Feeding intolerance 15.93 9.95 9 56324 1175 110531791
Neuropathy peripheral 15.79 9.95 150 56183 179127 110353839
Laryngeal pain 15.29 9.95 17 56316 5958 110527008
Platelet count decreased 15.24 9.95 182 56151 230261 110302705
Interstitial lung disease 15.16 9.95 30 56303 139304 110393662
Transfusion 14.75 9.95 37 56296 25435 110507531
Ataxia 14.66 9.95 41 56292 30067 110502899
Abdominal pain 14.55 9.95 353 55980 512636 110020330
Heavy menstrual bleeding 14.26 9.95 28 56305 16337 110516629
Cytomegalovirus infection 14.17 9.95 5 56328 54439 110478527
Hepatitis 14.11 9.95 15 56318 90039 110442927
Autoimmune disorder 13.94 9.95 8 56325 65475 110467491
Asthma 13.82 9.95 73 56260 250218 110282748
Breast cancer stage III 13.77 9.95 12 56321 79105 110453861
Infective pulmonary exacerbation of cystic fibrosis 13.77 9.95 26 56307 14745 110518221
Rheumatic fever 13.67 9.95 26 56307 122553 110410413
Paraesthesia 13.59 9.95 207 56126 276314 110256652
Chest pain 13.54 9.95 268 56065 376107 110156859
Coronary artery disease 13.41 9.95 72 56261 71618 110461348
Gastrointestinal haemorrhage 13.36 9.95 136 56197 165382 110367584
Bone pain 13.28 9.95 67 56266 65066 110467900
Atelectasis 13.22 9.95 45 56288 36667 110496299
Bronchitis 13.14 9.95 130 56203 156902 110376064
Coeliac disease 13.03 9.95 3 56330 43184 110489782
Red blood cell count decreased 12.87 9.95 67 56266 65856 110467110
Application site erythema 12.73 9.95 15 56318 5595 110527371
Gallbladder disorder 12.66 9.95 31 56302 20998 110511968
Inflammation 12.64 9.95 53 56280 193185 110339781
Rotator cuff syndrome 12.59 9.95 27 56306 16767 110516199
Therapeutic product effect decreased 12.53 9.95 73 56260 244243 110288723
Accidental exposure to product 12.34 9.95 5 56328 50003 110482963
Altered state of consciousness 12.32 9.95 7 56326 57619 110475347
Blood glucose decreased 12.30 9.95 38 56295 29450 110503516
Coma 12.29 9.95 26 56307 117843 110415123
Pain in jaw 12.14 9.95 55 56278 51122 110481844
Alopecia 12.10 9.95 123 56210 364630 110168336
Hypophagia 12.07 9.95 56 56277 52570 110480396
Muscle spasticity 12.05 9.95 43 56290 35872 110497094
Gastrooesophageal reflux disease 11.83 9.95 142 56191 179834 110353132
Transient ischaemic attack 11.79 9.95 64 56269 63918 110469048
Application site discolouration 11.54 9.95 7 56326 1042 110531924
Injection site nodule 11.51 9.95 13 56320 4633 110528333
Dislocation of vertebra 11.41 9.95 4 56329 43717 110489249
Anaphylactic shock 11.40 9.95 6 56327 51540 110481426
Gait disturbance 11.35 9.95 202 56131 278006 110254960
Cardiac pacemaker insertion 11.34 9.95 15 56318 6286 110526680
Application site pain 11.33 9.95 14 56319 5485 110527481
Lethargy 11.27 9.95 84 56249 93492 110439474
Peripheral venous disease 11.09 9.95 16 56317 84101 110448865
Neoplasm progression 11.00 9.95 10 56323 64585 110468381
Hospitalisation 10.99 9.95 116 56217 142377 110390589
Multiple organ dysfunction syndrome 10.95 9.95 40 56293 151670 110381296
Swollen joint count increased 10.95 9.95 16 56317 83645 110449321
Vision blurred 10.89 9.95 107 56226 128915 110404051
Abdominal adhesions 10.86 9.95 12 56321 4178 110528788
Dialysis 10.84 9.95 28 56305 19591 110513375
Neurotoxicity 10.78 9.95 4 56329 42203 110490763
Disease complication 10.69 9.95 14 56319 5813 110527153
Liver disorder 10.60 9.95 37 56296 142206 110390760
Intestinal dilatation 10.49 9.95 11 56322 3609 110529357
Intestinal mucosal hypertrophy 10.41 9.95 5 56328 467 110532499
Therapy partial responder 10.36 9.95 3 56330 37058 110495908
Myalgia 10.36 9.95 165 56168 222216 110310750
Deep vein thrombosis postoperative 10.31 9.95 9 56324 59282 110473684
Granulocytopenia 10.18 9.95 21 56312 12694 110520272
Laboratory test abnormal 10.18 9.95 47 56286 44032 110488934
Hot flush 10.18 9.95 63 56270 65973 110466993
Wound drainage 10.15 9.95 7 56326 1297 110531669
Rash pruritic 10.15 9.95 85 56248 97984 110434982
Skin laceration 10.14 9.95 39 56294 33714 110499252
Rib fracture 10.13 9.95 39 56294 33731 110499235
Lactic acidosis 10.08 9.95 20 56313 92791 110440175
Progressive multiple sclerosis 10.05 9.95 7 56326 1317 110531649
Ovarian cyst 9.99 9.95 22 56311 13908 110519058

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA31 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC D03AX04 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:49201 anti-ulcer drug

Related Drugs by ATC class:

A11HA Other plain vitamin preparations 10 drugs
biotindexpanthenolinositolnicotinamidepantethinepyridoxal phosphatepyridoxineriboflavintocofersolanVitamin E
D03AX Other cicatrizants 9 drugs
becaplerminberemagene geperpaveccrilanomerdexpanthenolenoxolonehyaluronic acidsodium chloritetrafermintrolamine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ascorbic acid deficiency indication 76169001
Pantothenic acid deficiency indication 238128006
Methemoglobinemia off-label use 38959009 DOID:10783
Primary hyperoxaluria contraindication 17901006 DOID:2977
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Hemochromatosis contraindication 399187006 DOID:2352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.62 acidic
pKa2 12.98 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
568ET80C3D UNII
4020312 VUID
N0000178898 NUI
D01082 KEGG_DRUG
4017627 VANDF
4017672 VANDF
4020312 VANDF
4021034 VANDF
4021902 VANDF
C0006710 UMLSCUI
CHEBI:31345 CHEBI
PAU PDB_CHEM_ID
CHEMBL1901349 ChEMBL_ID
443753 PUBCHEM_CID
CHEMBL1594 ChEMBL_ID
D010205 MESH_DESCRIPTOR_UI
1260 INN_ID
DB01783 DRUGBANK_ID
1918 RXNORM
5685 MMSL
7440 MMSL
NOCODE MMSL
001056 NDDF
001057 NDDF
126225001 SNOMEDCT_US
66441000 SNOMEDCT_US
86431009 SNOMEDCT_US
4668 IUPHAR_LIGAND_ID
137-08-6 SECONDARY_CAS_RN
568ET80C3D INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 7.50 mg ORAL unapproved drug other 14 sections
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 7.50 mg ORAL unapproved drug other 14 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 25 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
JBA Collagen-Electrolyte Mocktail HUMAN OTC DRUG LABEL 12 13411-848 POWDER 6 mg ORAL unapproved drug other 6 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 7 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 7 mg ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 10 mg ORAL unapproved drug other 18 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 1 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 17856-0010 TABLET, COATED 10 mg ORAL Unapproved drug other 8 sections
Centratex HUMAN PRESCRIPTION DRUG LABEL 13 23359-100 CAPSULE 10 mg ORAL unapproved drug other 13 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 6 mg ORAL unapproved drug other 10 sections
Multi Vitamin and Mineralvitamin HUMAN OTC DRUG LABEL 11 51220-2001 TABLET, CHEWABLE 1.50 mg ORAL unapproved drug other 8 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 7 mg ORAL unapproved drug other 13 sections
Concept DHA HUMAN PRESCRIPTION DRUG LABEL 15 52747-621 CAPSULE, LIQUID FILLED 5 mg ORAL unapproved drug other 7 sections
Integra Plus HUMAN PRESCRIPTION DRUG LABEL 10 52747-712 CAPSULE 5 mg ORAL unapproved drug other 12 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 10 mg ORAL unapproved drug other 8 sections
MyhephronDialysis and Stress Supplement HUMAN PRESCRIPTION DRUG LABEL 9 58607-185 CAPSULE 5 mg ORAL unapproved drug other 8 sections
MYNEPHROCAPSDIALYSIS/STRESS Vitamin Supplement HUMAN PRESCRIPTION DRUG LABEL 9 58607-186 CAPSULE 5 mg ORAL unapproved drug other 9 sections
Finazol HUMAN PRESCRIPTION DRUG LABEL 24 59088-008 TABLET 15 mg ORAL unapproved drug other 13 sections
Boostervite HUMAN PRESCRIPTION DRUG LABEL 16 59088-022 TABLET 50 mg ORAL unapproved drug other 15 sections
PureVit DualFe Plus HUMAN PRESCRIPTION DRUG LABEL 13 59088-112 CAPSULE 10 mg ORAL unapproved drug other 12 sections
Diatrol HUMAN PRESCRIPTION DRUG LABEL 17 59088-162 TABLET 8 mg ORAL unapproved drug other 11 sections
Zintrexyl-C HUMAN PRESCRIPTION DRUG LABEL 24 59088-180 TABLET 15 mg ORAL unapproved drug other 13 sections
Folitin-Z HUMAN PRESCRIPTION DRUG LABEL 24 59088-181 TABLET 15 mg ORAL unapproved drug other 13 sections
Ribotin-E HUMAN PRESCRIPTION DRUG LABEL 24 59088-182 TABLET 15 mg ORAL unapproved drug other 13 sections