dexpanthenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	838	81-13-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dexpanthenol (+)-panthenol bepanthen D-Panthenol	The alcohol of pantothenic acid Molecular weight: 205.25 Formula: C9H19NO4 CLOGP: -1.65 LIPINSKI: 0 HAC: 5 HDO: 4 TPSA: 89.79 ALOGS: -0.23 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexpanthenol
(+)-panthenol
bepanthen
D-Panthenol

The alcohol of pantothenic acid

Molecular weight: 205.25
Formula: C9H19NO4
CLOGP: -1.65
LIPINSKI: 0
HAC: 5
HDO: 4
TPSA: 89.79
ALOGS: -0.23
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	195.59	16.42	80	4808	34460	63449674
Gastrooesophageal reflux disease	148.43	16.42	92	4796	95547	63388587
Coma	134.24	16.42	75	4813	64289	63419845
Somnolence	82.25	16.42	84	4804	178601	63305533
Underdose	41.42	16.42	26	4862	27430	63456704
Intestinal haemorrhage	36.48	16.42	13	4875	3834	63480300
Female genital tract fistula	34.34	16.42	15	4873	7544	63476590
Pulmonary vein occlusion	33.34	16.42	6	4882	105	63484029
Chronic sinusitis	29.55	16.42	16	4872	12827	63471307
Vaginal flatulence	27.01	16.42	10	4878	3283	63480851

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile bone marrow aplasia	41.13	20.47	17	2443	8192	34946279
Generalised oedema	37.40	20.47	18	2442	12390	34942081
Face oedema	35.60	20.47	17	2443	11499	34942972
General physical health deterioration	31.82	20.47	42	2418	128227	34826244
Anaemia	25.80	20.47	53	2407	233282	34721189
Dysuria	22.11	20.47	17	2443	27135	34927336

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrooesophageal reflux disease	100.47	15.77	78	6739	104168	79633403
Pneumonia aspiration	94.06	15.77	63	6754	66904	79670667
Coma	59.55	15.77	57	6760	100592	79636979
Somnolence	54.07	15.77	83	6734	238898	79498673
Female genital tract fistula	36.22	15.77	15	6802	5960	79731611
Underdose	34.50	15.77	26	6791	33125	79704446
Incorrect route of product administration	31.15	15.77	25	6792	34904	79702667
Pulmonary vein occlusion	30.95	15.77	6	6811	143	79737428
Intestinal haemorrhage	28.69	15.77	13	6804	6413	79731158
Vaginal flatulence	28.39	15.77	10	6807	2565	79735006

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A11HA30	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
ATC	D03AX03	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS CICATRIZANTS Other cicatrizants
ATC	S01XA12	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
CHEBI has role	CHEBI:38323	cholinergic drugs
CHEBI has role	CHEBI:50188	provitamins

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Eczema	indication	43116000
Toxicodendron radicans	indication	52352005
Paralytic ileus	indication	55525008	DOID:8442
Diaper rash	indication	91487003
Disorder of skin	indication	95320005	DOID:37
Contact dermatitis due to poison oak	indication	200824008
Gastroparesis	indication	235675006
Arthropod bite wound	indication	409985002
Paralytic Ileus Prevention	indication
Chafing of skin	off-label use	238474002

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.71	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
001696	NDDF
1023	INN_ID
126226000	SNOMEDCT_US
131204	PUBCHEM_CID
1536	MMSL
1O6C93RI7Z	UNII
22701	RXNORM
4017657	VANDF
4020828	VUID
4020828	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7862	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7862	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7874	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7874	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9007	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9007	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9015	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9015	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections

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