dexpanthenol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
838 81-13-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexpanthenol
  • (+)-panthenol
  • bepanthen
  • D-Panthenol
The alcohol of pantothenic acid
  • Molecular weight: 205.25
  • Formula: C9H19NO4
  • CLOGP: -1.65
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 89.79
  • ALOGS: -0.23
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 146.52 11.45 128 25242 31477 46629215
Gastrooesophageal reflux disease 120.83 11.45 174 25196 74170 46586522
Toxicity to various agents 80.87 11.45 10 25360 211756 46448936
Coma 76.98 11.45 124 25246 58225 46602467
Neuropathy peripheral 69.59 11.45 153 25217 90740 46569952
Somnolence 63.36 11.45 208 25162 156313 46504379
Fatigue 60.88 11.45 549 24821 608148 46052544
Diarrhoea 41.06 11.45 474 24896 559128 46101564
Full blood count decreased 39.01 11.45 54 25316 22157 46638535
Muscle spasms 34.96 11.45 146 25224 122967 46537725
Drug hypersensitivity 28.39 11.45 56 25314 243769 46416923
Dry skin 26.90 11.45 65 25305 40951 46619741
Off label use 26.12 11.45 112 25258 379729 46280963
Drug ineffective 24.58 11.45 243 25127 677595 45983097
Product compounding quality issue 24.49 11.45 7 25363 138 46660554
Drug abuse 24.15 11.45 3 25367 63405 46597287
Drug interaction 22.48 11.45 48 25322 203046 46457646
Contraindicated product administered 21.93 11.45 8 25362 79939 46580753
Product dose omission issue 21.51 11.45 161 25209 168359 46492333
Synovitis 20.74 11.45 4 25366 61071 46599621
Intentional overdose 20.54 11.45 5 25365 64939 46595753
White blood cell count decreased 20.28 11.45 117 25253 112114 46548578
Acute kidney injury 19.12 11.45 65 25305 235790 46424902
Multiple sclerosis relapse 18.84 11.45 58 25312 42067 46618625
Peripheral swelling 18.49 11.45 148 25222 157923 46502769
Maternal condition affecting foetus 18.33 11.45 6 25364 189 46660503
Balance disorder 17.89 11.45 76 25294 64445 46596247
Suicide attempt 17.87 11.45 4 25366 55032 46605660
Rheumatoid arthritis 17.62 11.45 69 25301 240146 46420546
Diabetic foot 17.48 11.45 11 25359 1639 46659053
Systemic lupus erythematosus 17.09 11.45 7 25363 65173 46595519
Sleep apnoea syndrome 16.54 11.45 37 25333 22164 46638528
Tooth disorder 16.43 11.45 38 25332 23265 46637427
Exposure during pregnancy 16.21 11.45 21 25349 108191 46552501
Hypoaesthesia 15.98 11.45 115 25255 118754 46541938
Poor quality sleep 15.62 11.45 29 25341 15224 46645468
Interstitial lung disease 15.49 11.45 5 25365 53944 46606748
Fall 15.15 11.45 257 25113 328840 46331852
Treatment failure 15.07 11.45 17 25353 93070 46567622
Arrhythmia neonatal 14.55 11.45 4 25366 68 46660624
Nasopharyngitis 14.27 11.45 137 25233 153861 46506831
Skin abrasion 13.96 11.45 20 25350 8468 46652224
Multiple lentigines syndrome 13.38 11.45 5 25365 234 46660458
Optic nerve disorder 13.37 11.45 7 25363 737 46659955
Seasonal allergy 13.21 11.45 25 25345 13309 46647383
Nonalcoholic fatty liver disease 12.98 11.45 7 25363 782 46659910
Chronic kidney disease-mineral and bone disorder 12.79 11.45 5 25365 265 46660427
Sinus disorder 12.79 11.45 28 25342 16535 46644157
Sinusitis 12.30 11.45 116 25254 129652 46531040
Memory impairment 12.29 11.45 78 25292 77259 46583433
Naevus flammeus 12.22 11.45 4 25366 126 46660566
Rosacea 12.18 11.45 12 25358 3429 46657263
Insomnia 12.12 11.45 140 25230 164784 46495908
Gonorrhoea 11.84 11.45 4 25366 139 46660553
Urine calcium/creatinine ratio increased 11.79 11.45 4 25366 141 46660551
Rhinorrhoea 11.59 11.45 54 25316 47611 46613081
Pre-existing condition improved 11.49 11.45 16 25354 6596 46654096

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 70.28 13.05 110 11579 70365 29870424
Fatigue 50.23 13.05 252 11437 320421 29620368
Toxicity to various agents 34.56 13.05 13 11676 177170 29763619
Full blood count decreased 30.40 13.05 34 11655 15683 29925106
Cerebral haemorrhage neonatal 26.46 13.05 8 11681 272 29940517
Multiple sclerosis relapse 20.15 13.05 23 11666 10839 29929950
Relapsing-remitting multiple sclerosis 18.60 13.05 6 11683 253 29940536
Dysuria 18.14 13.05 32 11657 22509 29918280
Stiff person syndrome 17.50 13.05 5 11684 139 29940650
Generalised oedema 16.90 13.05 22 11667 11863 29928926
Rash 16.72 13.05 130 11559 191759 29749030
Febrile bone marrow aplasia 16.49 13.05 18 11671 8079 29932710
Plasma cell myeloma 16.39 13.05 52 11637 53410 29887379
Dermatitis contact 16.30 13.05 12 11677 3219 29937570
Constipation 15.65 13.05 86 11603 112820 29827969
Insomnia 14.94 13.05 74 11615 93262 29847527
Pseudopolyposis 14.20 13.05 3 11686 22 29940767
Drug interaction 14.18 13.05 36 11653 199532 29741257
Influenza 14.03 13.05 43 11646 43355 29897434
Muscle spasms 13.83 13.05 56 11633 64782 29876007
Sleep apnoea syndrome 13.65 13.05 24 11665 16833 29923956
Balance disorder 13.56 13.05 38 11651 36455 29904334
Product dose omission issue 13.51 13.05 71 11618 91560 29849229
Back pain 13.45 13.05 77 11612 102519 29838270
Peripheral swelling 13.23 13.05 53 11636 61021 29879768
Pouchitis 13.18 13.05 6 11683 651 29940138

Pharmacologic Action:

SourceCodeDescription
ATC A11HA30 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC D03AX03 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
ATC S01XA12 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
CHEBI has role CHEBI:38323 cholinergic drugs
CHEBI has role CHEBI:50188 provitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Eczema indication 43116000
Toxicodendron radicans indication 52352005
Paralytic ileus indication 55525008 DOID:8442
Diaper rash indication 91487003
Disorder of skin indication 95320005 DOID:37
Contact dermatitis due to poison oak indication 200824008
Gastroparesis indication 235675006
Arthropod bite wound indication 409985002
Paralytic Ileus Prevention indication
Chafing of skin off-label use 238474002
Eruption of skin off-label use 271807003 DOID:0050486
Skin irritation off-label use 367466007
Itching of skin off-label use 418363000
Hemophilia contraindication 90935002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4020828 VUID
N0000146036 NUI
4017657 VANDF
4020828 VANDF
C0057610 UMLSCUI
CHEBI:27373 CHEBI
CHEMBL1200979 ChEMBL_ID
131204 PUBCHEM_CID
DB09357 DRUGBANK_ID
C007288 MESH_SUPPLEMENTAL_RECORD_UI
1023 INN_ID
1O6C93RI7Z UNII
22701 RXNORM
1536 MMSL
4558 MMSL
d01001 MMSL
001696 NDDF
126226000 SNOMEDCT_US
404842009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
B-PLEX 100 HUMAN PRESCRIPTION DRUG LABEL 5 30727-300 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
HASOL Anagen Hair Tonic HUMAN OTC DRUG LABEL 3 51270-122 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Anagen Scalp HUMAN OTC DRUG LABEL 3 51270-123 SHAMPOO 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Anti Hair Loss HUMAN OTC DRUG LABEL 3 51270-124 SHAMPOO 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Vital For Hair-Loss Tonic HUMAN OTC DRUG LABEL 3 51270-125 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION HUMAN PRESCRIPTION DRUG LABEL 13 54643-5646 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 17 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 17 sections
Infuvite Adult Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-5650 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7862 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7874 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7886 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9007 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9015 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9023 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
M.V.I. Pediatric HUMAN PRESCRIPTION DRUG LABEL 13 61703-421 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 mg INTRAVENOUS NDA 21 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 67457-146 INJECTION 2 mg INTRAVENOUS Unapproved drug other 9 sections
NDM SCALP HUMAN OTC DRUG LABEL 4 69288-001 SHAMPOO 1.40 g TOPICAL unapproved drug other 11 sections
YOZUM WELL BEING HAIR COLOR HUMAN OTC DRUG LABEL 1 69525-2001 LIQUID 0.20 g TOPICAL OTC monograph not final 7 sections
Notamo Hair Tonic HUMAN OTC DRUG LABEL 2 69709-102 LIQUID 0.20 1 TOPICAL unapproved drug other 8 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 69877-026 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
B-Combo HUMAN PRESCRIPTION DRUG LABEL 6 70104-110 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Therapytion Hair Tonic HUMAN OTC DRUG LABEL 2 70477-101 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
VITAMIN B COMPLEX HUMAN PRESCRIPTION DRUG LABEL 5 71414-225 INJECTION 2 mg INTRAVENOUS unapproved drug other 9 sections
Pelo Scalp Tonic Sheet HUMAN OTC DRUG LABEL 3 73099-010 PATCH 0.07 g TOPICAL unapproved drug other 9 sections
BABYSONS HUMAN OTC DRUG LABEL 1 73519-001 OINTMENT 50 mg TOPICAL OTC monograph not final 11 sections
Yakkongmo scalp deep cleansingshampoo HUMAN OTC DRUG LABEL 4 73540-001 SHAMPOO 0.50 g TOPICAL unapproved drug other 7 sections
Yakkongmo hair serum tonic HUMAN OTC DRUG LABEL 3 73540-002 LIQUID 0.20 g TOPICAL unapproved drug other 7 sections
Yakkongmo treatment HUMAN OTC DRUG LABEL 3 73540-003 LIQUID 0.50 g TOPICAL unapproved drug other 7 sections