dexpanthenol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	838	81-13-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dexpanthenol (+)-panthenol bepanthen D-Panthenol	The alcohol of pantothenic acid Molecular weight: 205.25 Formula: C9H19NO4 CLOGP: -1.65 LIPINSKI: 0 HAC: 5 HDO: 4 TPSA: 89.79 ALOGS: -0.23 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexpanthenol
(+)-panthenol
bepanthen
D-Panthenol

The alcohol of pantothenic acid

Molecular weight: 205.25
Formula: C9H19NO4
CLOGP: -1.65
LIPINSKI: 0
HAC: 5
HDO: 4
TPSA: 89.79
ALOGS: -0.23
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	146.52	11.45	128	25242	31477	46629215
Gastrooesophageal reflux disease	120.83	11.45	174	25196	74170	46586522
Toxicity to various agents	80.87	11.45	10	25360	211756	46448936
Coma	76.98	11.45	124	25246	58225	46602467
Neuropathy peripheral	69.59	11.45	153	25217	90740	46569952
Somnolence	63.36	11.45	208	25162	156313	46504379
Fatigue	60.88	11.45	549	24821	608148	46052544
Diarrhoea	41.06	11.45	474	24896	559128	46101564
Full blood count decreased	39.01	11.45	54	25316	22157	46638535
Muscle spasms	34.96	11.45	146	25224	122967	46537725
Drug hypersensitivity	28.39	11.45	56	25314	243769	46416923
Dry skin	26.90	11.45	65	25305	40951	46619741
Off label use	26.12	11.45	112	25258	379729	46280963
Drug ineffective	24.58	11.45	243	25127	677595	45983097
Product compounding quality issue	24.49	11.45	7	25363	138	46660554
Drug abuse	24.15	11.45	3	25367	63405	46597287
Drug interaction	22.48	11.45	48	25322	203046	46457646
Contraindicated product administered	21.93	11.45	8	25362	79939	46580753
Product dose omission issue	21.51	11.45	161	25209	168359	46492333
Synovitis	20.74	11.45	4	25366	61071	46599621
Intentional overdose	20.54	11.45	5	25365	64939	46595753
White blood cell count decreased	20.28	11.45	117	25253	112114	46548578
Acute kidney injury	19.12	11.45	65	25305	235790	46424902
Multiple sclerosis relapse	18.84	11.45	58	25312	42067	46618625
Peripheral swelling	18.49	11.45	148	25222	157923	46502769
Maternal condition affecting foetus	18.33	11.45	6	25364	189	46660503
Balance disorder	17.89	11.45	76	25294	64445	46596247
Suicide attempt	17.87	11.45	4	25366	55032	46605660
Rheumatoid arthritis	17.62	11.45	69	25301	240146	46420546
Diabetic foot	17.48	11.45	11	25359	1639	46659053
Systemic lupus erythematosus	17.09	11.45	7	25363	65173	46595519
Sleep apnoea syndrome	16.54	11.45	37	25333	22164	46638528
Tooth disorder	16.43	11.45	38	25332	23265	46637427
Exposure during pregnancy	16.21	11.45	21	25349	108191	46552501
Hypoaesthesia	15.98	11.45	115	25255	118754	46541938
Poor quality sleep	15.62	11.45	29	25341	15224	46645468
Interstitial lung disease	15.49	11.45	5	25365	53944	46606748
Fall	15.15	11.45	257	25113	328840	46331852
Treatment failure	15.07	11.45	17	25353	93070	46567622
Arrhythmia neonatal	14.55	11.45	4	25366	68	46660624
Nasopharyngitis	14.27	11.45	137	25233	153861	46506831
Skin abrasion	13.96	11.45	20	25350	8468	46652224
Multiple lentigines syndrome	13.38	11.45	5	25365	234	46660458
Optic nerve disorder	13.37	11.45	7	25363	737	46659955
Seasonal allergy	13.21	11.45	25	25345	13309	46647383
Nonalcoholic fatty liver disease	12.98	11.45	7	25363	782	46659910
Chronic kidney disease-mineral and bone disorder	12.79	11.45	5	25365	265	46660427
Sinus disorder	12.79	11.45	28	25342	16535	46644157
Sinusitis	12.30	11.45	116	25254	129652	46531040
Memory impairment	12.29	11.45	78	25292	77259	46583433
Naevus flammeus	12.22	11.45	4	25366	126	46660566
Rosacea	12.18	11.45	12	25358	3429	46657263
Insomnia	12.12	11.45	140	25230	164784	46495908
Gonorrhoea	11.84	11.45	4	25366	139	46660553
Urine calcium/creatinine ratio increased	11.79	11.45	4	25366	141	46660551
Rhinorrhoea	11.59	11.45	54	25316	47611	46613081
Pre-existing condition improved	11.49	11.45	16	25354	6596	46654096

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuropathy peripheral	70.28	13.05	110	11579	70365	29870424
Fatigue	50.23	13.05	252	11437	320421	29620368
Toxicity to various agents	34.56	13.05	13	11676	177170	29763619
Full blood count decreased	30.40	13.05	34	11655	15683	29925106
Cerebral haemorrhage neonatal	26.46	13.05	8	11681	272	29940517
Multiple sclerosis relapse	20.15	13.05	23	11666	10839	29929950
Relapsing-remitting multiple sclerosis	18.60	13.05	6	11683	253	29940536
Dysuria	18.14	13.05	32	11657	22509	29918280
Stiff person syndrome	17.50	13.05	5	11684	139	29940650
Generalised oedema	16.90	13.05	22	11667	11863	29928926
Rash	16.72	13.05	130	11559	191759	29749030
Febrile bone marrow aplasia	16.49	13.05	18	11671	8079	29932710
Plasma cell myeloma	16.39	13.05	52	11637	53410	29887379
Dermatitis contact	16.30	13.05	12	11677	3219	29937570
Constipation	15.65	13.05	86	11603	112820	29827969
Insomnia	14.94	13.05	74	11615	93262	29847527
Pseudopolyposis	14.20	13.05	3	11686	22	29940767
Drug interaction	14.18	13.05	36	11653	199532	29741257
Influenza	14.03	13.05	43	11646	43355	29897434
Muscle spasms	13.83	13.05	56	11633	64782	29876007
Sleep apnoea syndrome	13.65	13.05	24	11665	16833	29923956
Balance disorder	13.56	13.05	38	11651	36455	29904334
Product dose omission issue	13.51	13.05	71	11618	91560	29849229
Back pain	13.45	13.05	77	11612	102519	29838270
Peripheral swelling	13.23	13.05	53	11636	61021	29879768
Pouchitis	13.18	13.05	6	11683	651	29940138

Pharmacologic Action:

Source	Code	Description
ATC	A11HA30	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
ATC	D03AX03	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS CICATRIZANTS Other cicatrizants
ATC	S01XA12	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
CHEBI has role	CHEBI:38323	cholinergic drugs
CHEBI has role	CHEBI:50188	provitamins

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Eczema	indication	43116000
Toxicodendron radicans	indication	52352005
Paralytic ileus	indication	55525008	DOID:8442
Diaper rash	indication	91487003
Disorder of skin	indication	95320005	DOID:37
Contact dermatitis due to poison oak	indication	200824008
Gastroparesis	indication	235675006
Arthropod bite wound	indication	409985002
Paralytic Ileus Prevention	indication
Chafing of skin	off-label use	238474002
Eruption of skin	off-label use	271807003	DOID:0050486
Skin irritation	off-label use	367466007
Itching of skin	off-label use	418363000
Hemophilia	contraindication	90935002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.71	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4020828	VUID
N0000146036	NUI
4017657	VANDF
4020828	VANDF
C0057610	UMLSCUI
CHEBI:27373	CHEBI
CHEMBL1200979	ChEMBL_ID
131204	PUBCHEM_CID
DB09357	DRUGBANK_ID
C007288	MESH_SUPPLEMENTAL_RECORD_UI
1023	INN_ID
1O6C93RI7Z	UNII
22701	RXNORM
1536	MMSL
4558	MMSL
d01001	MMSL
001696	NDDF
126226000	SNOMEDCT_US
404842009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
B-PLEX 100	HUMAN PRESCRIPTION DRUG LABEL	5	30727-300	INJECTION, SOLUTION	2 mg	INTRAMUSCULAR	unapproved drug other	10 sections
HASOL Anagen Hair Tonic	HUMAN OTC DRUG LABEL	3	51270-122	LIQUID	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Anagen Scalp	HUMAN OTC DRUG LABEL	3	51270-123	SHAMPOO	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Anti Hair Loss	HUMAN OTC DRUG LABEL	3	51270-124	SHAMPOO	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Vital For Hair-Loss Tonic	HUMAN OTC DRUG LABEL	3	51270-125	LIQUID	0.00 1	TOPICAL	unapproved drug other	8 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5646	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections
Infuvite Adult Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5650	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7862	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7874	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Pediatric Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7886	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9007	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9015	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Pediatric Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9023	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
M.V.I. Pediatric	HUMAN PRESCRIPTION DRUG LABEL	13	61703-421	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 mg	INTRAVENOUS	NDA	21 sections
Vitamin B Complex	HUMAN PRESCRIPTION DRUG LABEL	5	67457-146	INJECTION	2 mg	INTRAVENOUS	Unapproved drug other	9 sections
NDM SCALP	HUMAN OTC DRUG LABEL	4	69288-001	SHAMPOO	1.40 g	TOPICAL	unapproved drug other	11 sections
YOZUM WELL BEING HAIR COLOR	HUMAN OTC DRUG LABEL	1	69525-2001	LIQUID	0.20 g	TOPICAL	OTC monograph not final	7 sections
Notamo Hair Tonic	HUMAN OTC DRUG LABEL	2	69709-102	LIQUID	0.20 1	TOPICAL	unapproved drug other	8 sections
Vitamin B Complex	HUMAN PRESCRIPTION DRUG LABEL	5	69877-026	INJECTION, SOLUTION	2 mg	INTRAMUSCULAR	unapproved drug other	10 sections
B-Combo	HUMAN PRESCRIPTION DRUG LABEL	6	70104-110	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Lipovite	HUMAN PRESCRIPTION DRUG LABEL	13	70104-128	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Therapytion Hair Tonic	HUMAN OTC DRUG LABEL	2	70477-101	LIQUID	0.00 1	TOPICAL	unapproved drug other	8 sections
VITAMIN B COMPLEX	HUMAN PRESCRIPTION DRUG LABEL	5	71414-225	INJECTION	2 mg	INTRAVENOUS	unapproved drug other	9 sections
Pelo Scalp Tonic Sheet	HUMAN OTC DRUG LABEL	3	73099-010	PATCH	0.07 g	TOPICAL	unapproved drug other	9 sections
BABYSONS	HUMAN OTC DRUG LABEL	1	73519-001	OINTMENT	50 mg	TOPICAL	OTC monograph not final	11 sections
Yakkongmo scalp deep cleansingshampoo	HUMAN OTC DRUG LABEL	4	73540-001	SHAMPOO	0.50 g	TOPICAL	unapproved drug other	7 sections
Yakkongmo hair serum tonic	HUMAN OTC DRUG LABEL	3	73540-002	LIQUID	0.20 g	TOPICAL	unapproved drug other	7 sections
Yakkongmo treatment	HUMAN OTC DRUG LABEL	3	73540-003	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections