pyridoxine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2836 | 65-23-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.16 | g | O |
| 0.16 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 222 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 39.43 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.66 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 7.90 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.98 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 29, 1993 | FDA | HOSPIRA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Rheumatoid arthritis | 914.18 | 9.96 | 3732 | 325804 | 236483 | 46120043 |
| Pemphigus | 812.99 | 9.96 | 1277 | 328259 | 43997 | 46312529 |
| Completed suicide | 767.81 | 9.96 | 72 | 329464 | 145848 | 46210678 |
| Systemic lupus erythematosus | 688.76 | 9.96 | 1461 | 328075 | 63719 | 46292807 |
| Glossodynia | 542.70 | 9.96 | 1057 | 328479 | 43316 | 46313210 |
| Toxicity to various agents | 465.41 | 9.96 | 485 | 329051 | 211281 | 46145245 |
| Maternal exposure during pregnancy | 426.43 | 9.96 | 1640 | 327896 | 100909 | 46255617 |
| Hand deformity | 395.52 | 9.96 | 801 | 328735 | 33773 | 46322753 |
| Alopecia | 344.90 | 9.96 | 2142 | 327394 | 160272 | 46196254 |
| Arthropathy | 332.92 | 9.96 | 1331 | 328205 | 83369 | 46273157 |
| Drug abuse | 328.79 | 9.96 | 33 | 329503 | 63375 | 46293151 |
| Abdominal discomfort | 324.91 | 9.96 | 2000 | 327536 | 149165 | 46207361 |
| Pain | 286.19 | 9.96 | 4838 | 324698 | 472110 | 45884416 |
| Death | 284.98 | 9.96 | 1309 | 328227 | 334239 | 46022287 |
| Joint swelling | 283.40 | 9.96 | 2075 | 327461 | 163998 | 46192528 |
| Infusion related reaction | 278.30 | 9.96 | 1431 | 328105 | 99777 | 46256749 |
| Intentional overdose | 270.62 | 9.96 | 63 | 329473 | 64881 | 46291645 |
| Exposure during pregnancy | 268.90 | 9.96 | 1488 | 328048 | 106724 | 46249802 |
| Arthralgia | 259.52 | 9.96 | 3807 | 325729 | 360796 | 45995730 |
| Wound | 243.53 | 9.96 | 760 | 328776 | 42042 | 46314484 |
| Drug interaction | 235.48 | 9.96 | 696 | 328840 | 202398 | 46154128 |
| Drug hypersensitivity | 196.87 | 9.96 | 968 | 328568 | 242857 | 46113669 |
| Synovitis | 196.10 | 9.96 | 903 | 328633 | 60172 | 46296354 |
| Overdose | 188.34 | 9.96 | 267 | 329269 | 101712 | 46254814 |
| Anti-cyclic citrullinated peptide antibody positive | 187.01 | 9.96 | 416 | 329120 | 18729 | 46337797 |
| Nasopharyngitis | 185.12 | 9.96 | 1779 | 327757 | 152219 | 46204307 |
| Contraindicated product administered | 172.30 | 9.96 | 1059 | 328477 | 78888 | 46277638 |
| Pericarditis | 168.93 | 9.96 | 459 | 329077 | 23468 | 46333058 |
| Rheumatoid factor positive | 159.20 | 9.96 | 407 | 329129 | 20054 | 46336472 |
| Swelling | 158.89 | 9.96 | 1457 | 328079 | 123054 | 46233472 |
| Cardiac arrest | 158.80 | 9.96 | 245 | 329291 | 90154 | 46266372 |
| Suicide attempt | 157.01 | 9.96 | 97 | 329439 | 54939 | 46301587 |
| Acute kidney injury | 156.79 | 9.96 | 998 | 328538 | 234857 | 46121669 |
| Hip arthroplasty | 151.13 | 9.96 | 370 | 329166 | 17742 | 46338784 |
| Febrile neutropenia | 150.02 | 9.96 | 274 | 329262 | 94353 | 46262173 |
| Product use issue | 133.37 | 9.96 | 1132 | 328404 | 93512 | 46263014 |
| Red blood cell sedimentation rate abnormal | 131.53 | 9.96 | 295 | 329241 | 13354 | 46343172 |
| Knee arthroplasty | 130.71 | 9.96 | 416 | 329120 | 23249 | 46333277 |
| Musculoskeletal stiffness | 127.67 | 9.96 | 1152 | 328384 | 96841 | 46259685 |
| Pregnancy | 126.86 | 9.96 | 451 | 329085 | 26686 | 46329840 |
| Injection site erythema | 126.17 | 9.96 | 929 | 328607 | 73498 | 46283028 |
| C-reactive protein abnormal | 123.10 | 9.96 | 380 | 329156 | 20890 | 46335636 |
| Sickle cell anaemia with crisis | 117.47 | 9.96 | 143 | 329393 | 3849 | 46352677 |
| Depressed level of consciousness | 117.17 | 9.96 | 98 | 329438 | 47471 | 46309055 |
| Discomfort | 112.62 | 9.96 | 637 | 328899 | 46033 | 46310493 |
| Device expulsion | 106.53 | 9.96 | 31 | 329505 | 27511 | 46329015 |
| Injection site pain | 106.41 | 9.96 | 1191 | 328345 | 105961 | 46250565 |
| Bradycardia | 101.50 | 9.96 | 196 | 329340 | 66102 | 46290424 |
| Lactic acidosis | 97.78 | 9.96 | 59 | 329477 | 33850 | 46322676 |
| Hyponatraemia | 97.64 | 9.96 | 376 | 329160 | 100956 | 46255570 |
| Cardiac failure | 97.64 | 9.96 | 267 | 329269 | 79681 | 46276845 |
| Injection site pruritus | 97.58 | 9.96 | 545 | 328991 | 39198 | 46317328 |
| Respiratory arrest | 95.89 | 9.96 | 60 | 329476 | 33756 | 46322770 |
| Cardio-respiratory arrest | 90.78 | 9.96 | 178 | 329358 | 59691 | 46296835 |
| Blood pressure fluctuation | 89.55 | 9.96 | 439 | 329097 | 30009 | 46326517 |
| Abortion spontaneous | 88.28 | 9.96 | 569 | 328967 | 43077 | 46313449 |
| Sopor | 87.14 | 9.96 | 17 | 329519 | 19811 | 46336715 |
| Malignant neoplasm progression | 86.86 | 9.96 | 207 | 329329 | 64719 | 46291807 |
| Injection site swelling | 84.82 | 9.96 | 531 | 329005 | 39796 | 46316730 |
| Arthritis | 84.45 | 9.96 | 876 | 328660 | 76440 | 46280086 |
| Injection site reaction | 83.79 | 9.96 | 602 | 328934 | 47247 | 46309279 |
| Psoriatic arthropathy | 81.56 | 9.96 | 487 | 329049 | 35892 | 46320634 |
| Osteoarthritis | 80.14 | 9.96 | 728 | 328808 | 61297 | 46295229 |
| Therapeutic product effect decreased | 77.43 | 9.96 | 908 | 328628 | 81693 | 46274833 |
| Drug reaction with eosinophilia and systemic symptoms | 76.37 | 9.96 | 58 | 329478 | 29490 | 46327036 |
| Product quality issue | 73.34 | 9.96 | 86 | 329450 | 35562 | 46320964 |
| Agitation | 73.08 | 9.96 | 178 | 329358 | 55237 | 46301289 |
| Intentional self-injury | 72.59 | 9.96 | 40 | 329496 | 24126 | 46332400 |
| Caesarean section | 72.57 | 9.96 | 270 | 329266 | 16333 | 46340193 |
| Rhabdomyolysis | 72.21 | 9.96 | 115 | 329421 | 41794 | 46314732 |
| Renal failure | 71.64 | 9.96 | 488 | 329048 | 113106 | 46243420 |
| Basal cell carcinoma | 71.04 | 9.96 | 310 | 329226 | 20177 | 46336349 |
| Disease progression | 69.25 | 9.96 | 370 | 329166 | 90930 | 46265596 |
| Confusional state | 67.90 | 9.96 | 761 | 328775 | 159131 | 46197395 |
| Duodenal ulcer perforation | 67.04 | 9.96 | 170 | 329366 | 8332 | 46348194 |
| Tuberculosis | 64.68 | 9.96 | 189 | 329347 | 10076 | 46346450 |
| Helicobacter infection | 64.52 | 9.96 | 206 | 329330 | 11530 | 46344996 |
| Fatigue | 63.22 | 9.96 | 5049 | 324487 | 603648 | 45752878 |
| Joint effusion | 62.75 | 9.96 | 207 | 329329 | 11788 | 46344738 |
| Sinusitis | 62.17 | 9.96 | 1273 | 328263 | 128495 | 46228031 |
| Premature delivery | 61.92 | 9.96 | 314 | 329222 | 21755 | 46334771 |
| Disability assessment scale score increased | 60.93 | 9.96 | 77 | 329459 | 2155 | 46354371 |
| Asthma | 60.88 | 9.96 | 387 | 329149 | 91155 | 46265371 |
| Dyspnoea | 60.34 | 9.96 | 3000 | 326536 | 512548 | 45843978 |
| Hypotension | 59.79 | 9.96 | 1220 | 328316 | 231369 | 46125157 |
| Electrocardiogram QT prolonged | 58.55 | 9.96 | 177 | 329359 | 51148 | 46305378 |
| Anxiety | 58.28 | 9.96 | 918 | 328618 | 181039 | 46175487 |
| Psoriasis | 57.63 | 9.96 | 826 | 328710 | 77778 | 46278748 |
| Neutropenia | 56.75 | 9.96 | 692 | 328844 | 142512 | 46214014 |
| Tremor | 56.63 | 9.96 | 532 | 329004 | 115107 | 46241419 |
| Tachycardia | 55.14 | 9.96 | 444 | 329092 | 99178 | 46257348 |
| Drug withdrawal syndrome | 53.24 | 9.96 | 69 | 329467 | 27315 | 46329211 |
| Joint laxity | 52.05 | 9.96 | 69 | 329467 | 2027 | 46354499 |
| Oropharyngeal pain | 51.86 | 9.96 | 773 | 328763 | 73395 | 46283131 |
| Pulmonary arterial hypertension | 51.79 | 9.96 | 64 | 329472 | 25864 | 46330662 |
| Drug dependence | 51.51 | 9.96 | 39 | 329497 | 19862 | 46336664 |
| Premature labour | 51.28 | 9.96 | 186 | 329350 | 11113 | 46345413 |
| Pre-eclampsia | 51.15 | 9.96 | 148 | 329388 | 7846 | 46348680 |
| Delirium | 51.14 | 9.96 | 117 | 329419 | 37111 | 46319415 |
| Cholestasis | 51.02 | 9.96 | 69 | 329467 | 26824 | 46329702 |
| Sedation | 50.73 | 9.96 | 52 | 329484 | 22858 | 46333668 |
| Impaired healing | 50.40 | 9.96 | 437 | 329099 | 36306 | 46320220 |
| Osteoporosis | 50.11 | 9.96 | 472 | 329064 | 40136 | 46316390 |
| Drug ineffective | 49.83 | 9.96 | 5486 | 324050 | 672352 | 45684174 |
| Injection site bruising | 48.97 | 9.96 | 424 | 329112 | 35212 | 46321314 |
| Localised infection | 48.55 | 9.96 | 311 | 329225 | 23490 | 46333036 |
| Live birth | 48.54 | 9.96 | 172 | 329364 | 10158 | 46346368 |
| Cytomegalovirus infection | 47.68 | 9.96 | 35 | 329501 | 18109 | 46338417 |
| Hepatocellular injury | 47.18 | 9.96 | 85 | 329451 | 29437 | 46327089 |
| Foetal exposure during pregnancy | 47.15 | 9.96 | 375 | 329161 | 30372 | 46326154 |
| Serotonin syndrome | 47.11 | 9.96 | 61 | 329475 | 24159 | 46332367 |
| Poisoning | 46.84 | 9.96 | 20 | 329516 | 13974 | 46342552 |
| Hypoglycaemia | 45.94 | 9.96 | 212 | 329324 | 54137 | 46302389 |
| Injection site rash | 45.78 | 9.96 | 227 | 329309 | 15586 | 46340940 |
| Treatment failure | 45.16 | 9.96 | 915 | 328621 | 92172 | 46264354 |
| Blood pressure diastolic abnormal | 44.67 | 9.96 | 121 | 329415 | 6173 | 46350353 |
| Gestational diabetes | 44.61 | 9.96 | 132 | 329404 | 7087 | 46349439 |
| Pain in extremity | 44.23 | 9.96 | 2241 | 327295 | 256439 | 46100087 |
| Maternal drugs affecting foetus | 44.20 | 9.96 | 111 | 329425 | 5407 | 46351119 |
| Shock | 43.55 | 9.96 | 54 | 329482 | 21791 | 46334735 |
| Hepatic function abnormal | 43.48 | 9.96 | 113 | 329423 | 34308 | 46322218 |
| Metabolic acidosis | 43.33 | 9.96 | 135 | 329401 | 38645 | 46317881 |
| Anaphylactic reaction | 43.23 | 9.96 | 210 | 329326 | 52902 | 46303624 |
| Neck deformity | 42.94 | 9.96 | 59 | 329477 | 1795 | 46354731 |
| Lower respiratory tract infection | 42.43 | 9.96 | 584 | 328952 | 54505 | 46302021 |
| Red blood cell sedimentation rate increased | 42.41 | 9.96 | 292 | 329244 | 22597 | 46333929 |
| Altered state of consciousness | 42.21 | 9.96 | 62 | 329474 | 23286 | 46333240 |
| Hepatic enzyme increased | 42.05 | 9.96 | 811 | 328725 | 80976 | 46275550 |
| Intentional product misuse | 41.53 | 9.96 | 181 | 329355 | 46947 | 46309579 |
| Hyperkalaemia | 40.99 | 9.96 | 201 | 329335 | 50508 | 46306018 |
| Coma | 40.69 | 9.96 | 243 | 329293 | 58106 | 46298420 |
| Hyperglycaemia | 39.96 | 9.96 | 121 | 329415 | 34950 | 46321576 |
| Rheumatoid nodule | 39.68 | 9.96 | 147 | 329389 | 8873 | 46347653 |
| Juvenile idiopathic arthritis | 39.46 | 9.96 | 89 | 329447 | 4043 | 46352483 |
| Influenza | 39.25 | 9.96 | 865 | 328671 | 88405 | 46268121 |
| Respiratory failure | 39.15 | 9.96 | 454 | 329082 | 94362 | 46262164 |
| Mydriasis | 38.80 | 9.96 | 13 | 329523 | 10540 | 46345986 |
| Herpes zoster | 38.35 | 9.96 | 683 | 328853 | 67189 | 46289337 |
| Hypothermia | 38.31 | 9.96 | 19 | 329517 | 12164 | 46344362 |
| Encephalopathy | 38.19 | 9.96 | 116 | 329420 | 33473 | 46323053 |
| Somnolence | 38.12 | 9.96 | 828 | 328708 | 155693 | 46200833 |
| Constipation | 37.65 | 9.96 | 938 | 328598 | 173159 | 46183367 |
| General physical health deterioration | 37.40 | 9.96 | 583 | 328953 | 115186 | 46241340 |
| Blood creatine phosphokinase increased | 37.38 | 9.96 | 88 | 329448 | 27636 | 46328890 |
| Blood pressure systolic abnormal | 37.11 | 9.96 | 104 | 329432 | 5413 | 46351113 |
| Urticaria | 36.97 | 9.96 | 597 | 328939 | 117295 | 46239231 |
| Infective pulmonary exacerbation of cystic fibrosis | 36.89 | 9.96 | 15 | 329521 | 10792 | 46345734 |
| Cardiac failure congestive | 36.84 | 9.96 | 442 | 329094 | 91308 | 46265218 |
| Foot deformity | 36.84 | 9.96 | 210 | 329326 | 15215 | 46341311 |
| Peripheral swelling | 36.62 | 9.96 | 1413 | 328123 | 156658 | 46199868 |
| Product use in unapproved indication | 36.59 | 9.96 | 434 | 329102 | 89839 | 46266687 |
| Nausea | 36.58 | 9.96 | 4273 | 325263 | 683181 | 45673345 |
| Diabetic ketoacidosis | 36.32 | 9.96 | 45 | 329491 | 18165 | 46338361 |
| Multiple organ dysfunction syndrome | 36.24 | 9.96 | 215 | 329321 | 51495 | 46305031 |
| Ejection fraction decreased | 36.12 | 9.96 | 44 | 329492 | 17893 | 46338633 |
| Vomiting | 36.10 | 9.96 | 2730 | 326806 | 450064 | 45906462 |
| Restlessness | 36.05 | 9.96 | 79 | 329457 | 25445 | 46331081 |
| Cerebral haemorrhage | 35.94 | 9.96 | 93 | 329443 | 28278 | 46328248 |
| Pulmonary embolism | 35.69 | 9.96 | 545 | 328991 | 108040 | 46248486 |
| Emotional distress | 35.67 | 9.96 | 105 | 329431 | 30602 | 46325924 |
| Pulmonary tuberculosis | 35.65 | 9.96 | 93 | 329443 | 4638 | 46351888 |
| Hallucination | 35.37 | 9.96 | 207 | 329329 | 49744 | 46306782 |
| Musculoskeletal pain | 35.23 | 9.96 | 693 | 328843 | 69435 | 46287091 |
| Femur fracture | 35.22 | 9.96 | 408 | 329128 | 36589 | 46319937 |
| Dizziness | 35.16 | 9.96 | 2005 | 327531 | 338409 | 46018117 |
| Syncope | 35.14 | 9.96 | 524 | 329012 | 104279 | 46252247 |
| Loss of personal independence in daily activities | 35.04 | 9.96 | 583 | 328953 | 56600 | 46299926 |
| Disorientation | 34.89 | 9.96 | 138 | 329398 | 36780 | 46319746 |
| Osteonecrosis of jaw | 34.84 | 9.96 | 125 | 329411 | 34277 | 46322249 |
| Nodule | 34.39 | 9.96 | 208 | 329328 | 15397 | 46341129 |
| Renal impairment | 34.35 | 9.96 | 347 | 329189 | 74025 | 46282501 |
| No adverse event | 34.26 | 9.96 | 125 | 329411 | 34106 | 46322420 |
| Disseminated intravascular coagulation | 33.84 | 9.96 | 51 | 329485 | 18954 | 46337572 |
| Drug resistance | 33.52 | 9.96 | 44 | 329492 | 17324 | 46339202 |
| Hypoxia | 33.51 | 9.96 | 221 | 329315 | 51617 | 46304909 |
| Multiple sclerosis relapse | 33.45 | 9.96 | 168 | 329368 | 41957 | 46314569 |
| Hyperhidrosis | 33.33 | 9.96 | 437 | 329099 | 88871 | 46267655 |
| Myocardial infarction | 32.91 | 9.96 | 487 | 329049 | 97041 | 46259485 |
| Angioedema | 32.34 | 9.96 | 155 | 329381 | 39187 | 46317339 |
| Ventricular septal defect | 32.16 | 9.96 | 81 | 329455 | 3953 | 46352573 |
| Hepatic failure | 32.16 | 9.96 | 124 | 329412 | 33292 | 46323234 |
| Bone erosion | 32.06 | 9.96 | 142 | 329394 | 9301 | 46347225 |
| Limb deformity | 31.92 | 9.96 | 75 | 329461 | 3501 | 46353025 |
| Ventricular tachycardia | 31.71 | 9.96 | 44 | 329492 | 16923 | 46339603 |
| Therapeutic response decreased | 31.46 | 9.96 | 453 | 329083 | 42692 | 46313834 |
| Torsade de pointes | 31.22 | 9.96 | 24 | 329512 | 12130 | 46344396 |
| Small for dates baby | 31.08 | 9.96 | 75 | 329461 | 3562 | 46352964 |
| Heart rate decreased | 30.72 | 9.96 | 351 | 329185 | 31372 | 46325154 |
| Posterior reversible encephalopathy syndrome | 30.63 | 9.96 | 37 | 329499 | 15104 | 46341422 |
| Disturbance in attention | 30.44 | 9.96 | 117 | 329419 | 31443 | 46325083 |
| Insomnia | 30.36 | 9.96 | 909 | 328627 | 164015 | 46192511 |
| Gastroenteritis viral | 30.01 | 9.96 | 225 | 329311 | 17894 | 46338632 |
| Malignant melanoma | 29.69 | 9.96 | 147 | 329389 | 10087 | 46346439 |
| Gestational hypertension | 29.63 | 9.96 | 54 | 329482 | 2101 | 46354425 |
| Myalgia | 29.42 | 9.96 | 653 | 328883 | 122435 | 46234091 |
| Bronchitis | 29.38 | 9.96 | 967 | 328569 | 105012 | 46251514 |
| Latent tuberculosis | 29.37 | 9.96 | 51 | 329485 | 1909 | 46354617 |
| Injection site warmth | 29.36 | 9.96 | 182 | 329354 | 13590 | 46342936 |
| Neck mass | 29.32 | 9.96 | 69 | 329467 | 3224 | 46353302 |
| Extrapyramidal disorder | 29.27 | 9.96 | 22 | 329514 | 11246 | 46345280 |
| Arthritis infective | 29.26 | 9.96 | 91 | 329445 | 5022 | 46351504 |
| Blood pressure diastolic decreased | 28.56 | 9.96 | 185 | 329351 | 14026 | 46342500 |
| Developmental hip dysplasia | 28.48 | 9.96 | 40 | 329496 | 1243 | 46355283 |
| Respiratory depression | 28.43 | 9.96 | 24 | 329512 | 11576 | 46344950 |
| Smear cervix abnormal | 28.41 | 9.96 | 58 | 329478 | 2458 | 46354068 |
| Abnormal behaviour | 28.26 | 9.96 | 67 | 329469 | 20991 | 46335535 |
| Haemoglobin decreased | 28.06 | 9.96 | 1145 | 328391 | 127804 | 46228722 |
| Inappropriate antidiuretic hormone secretion | 27.96 | 9.96 | 35 | 329501 | 14067 | 46342459 |
| Weight increased | 27.88 | 9.96 | 1424 | 328112 | 163049 | 46193477 |
| Neoplasm progression | 27.66 | 9.96 | 96 | 329440 | 26587 | 46329939 |
| Premature rupture of membranes | 27.45 | 9.96 | 81 | 329455 | 4342 | 46352184 |
| Oral herpes | 27.32 | 9.96 | 232 | 329304 | 19158 | 46337368 |
| Accidental overdose | 26.81 | 9.96 | 64 | 329472 | 20002 | 46336524 |
| Blood pressure systolic increased | 26.75 | 9.96 | 316 | 329220 | 28471 | 46328055 |
| Ventricular fibrillation | 26.72 | 9.96 | 25 | 329511 | 11471 | 46345055 |
| Enthesopathy | 26.40 | 9.96 | 83 | 329453 | 4607 | 46351919 |
| Unresponsive to stimuli | 26.30 | 9.96 | 127 | 329409 | 32047 | 46324479 |
| Anaphylactic shock | 26.04 | 9.96 | 66 | 329470 | 20208 | 46336318 |
| Febrile bone marrow aplasia | 26.03 | 9.96 | 8 | 329528 | 6854 | 46349672 |
| Grip strength decreased | 25.95 | 9.96 | 125 | 329411 | 8481 | 46348045 |
| Multiple fractures | 25.56 | 9.96 | 92 | 329444 | 5475 | 46351051 |
| Fibromyalgia | 25.46 | 9.96 | 380 | 329156 | 36083 | 46320443 |
| Blood pressure diastolic increased | 25.15 | 9.96 | 96 | 329440 | 5878 | 46350648 |
| Wheezing | 25.10 | 9.96 | 248 | 329288 | 53138 | 46303388 |
| Speech disorder | 25.01 | 9.96 | 151 | 329385 | 36016 | 46320510 |
| Metastases to liver | 24.96 | 9.96 | 64 | 329472 | 19521 | 46337005 |
| Joint stiffness | 24.94 | 9.96 | 297 | 329239 | 26811 | 46329715 |
| Joint destruction | 24.93 | 9.96 | 62 | 329474 | 3002 | 46353524 |
| Postoperative wound infection | 24.87 | 9.96 | 125 | 329411 | 8628 | 46347898 |
| Synovial cyst | 24.59 | 9.96 | 110 | 329426 | 7236 | 46349290 |
| Asthenia | 24.50 | 9.96 | 1877 | 327659 | 309198 | 46047328 |
| Mental status changes | 24.30 | 9.96 | 163 | 329373 | 37925 | 46318601 |
| Hypokalaemia | 24.30 | 9.96 | 456 | 329080 | 87568 | 46268958 |
| Neutrophil count decreased | 24.26 | 9.96 | 193 | 329343 | 43233 | 46313293 |
| Surgery | 24.17 | 9.96 | 310 | 329226 | 28475 | 46328051 |
| Loss of consciousness | 23.96 | 9.96 | 581 | 328955 | 107657 | 46248869 |
| Condition aggravated | 23.70 | 9.96 | 2023 | 327513 | 243029 | 46113497 |
| Seizure | 23.69 | 9.96 | 674 | 328862 | 122380 | 46234146 |
| Skin papilloma | 23.59 | 9.96 | 74 | 329462 | 4102 | 46352424 |
| Foetal death | 23.55 | 9.96 | 123 | 329413 | 8620 | 46347906 |
| Cellulitis | 23.40 | 9.96 | 656 | 328880 | 69632 | 46286894 |
| Skin ulcer | 23.34 | 9.96 | 340 | 329196 | 32118 | 46324408 |
| Tenosynovitis stenosans | 23.29 | 9.96 | 46 | 329490 | 1903 | 46354623 |
| Swollen joint count increased | 23.26 | 9.96 | 52 | 329484 | 2348 | 46354178 |
| Product administration error | 23.07 | 9.96 | 67 | 329469 | 19614 | 46336912 |
| Dyspnoea exertional | 23.07 | 9.96 | 235 | 329301 | 50054 | 46306472 |
| Squamous cell carcinoma | 23.05 | 9.96 | 113 | 329423 | 7723 | 46348803 |
| Psychotic disorder | 23.04 | 9.96 | 82 | 329454 | 22539 | 46333987 |
| Skin cancer | 23.00 | 9.96 | 123 | 329413 | 8700 | 46347826 |
| Drug level increased | 22.94 | 9.96 | 61 | 329475 | 18380 | 46338146 |
| Suicidal ideation | 22.86 | 9.96 | 271 | 329265 | 56111 | 46300415 |
| Rheumatic fever | 22.58 | 9.96 | 57 | 329479 | 2786 | 46353740 |
| Blood pressure increased | 22.56 | 9.96 | 1102 | 328434 | 125564 | 46230962 |
| Polyhydramnios | 22.47 | 9.96 | 46 | 329490 | 1953 | 46354573 |
| Acute generalised exanthematous pustulosis | 22.39 | 9.96 | 20 | 329516 | 9385 | 46347141 |
| International normalised ratio increased | 22.37 | 9.96 | 217 | 329319 | 46666 | 46309860 |
| Atrioventricular block complete | 22.37 | 9.96 | 13 | 329523 | 7614 | 46348912 |
| Metastases to bone | 22.36 | 9.96 | 57 | 329479 | 17419 | 46339107 |
| Arrhythmia | 22.28 | 9.96 | 149 | 329387 | 34692 | 46321834 |
| Agranulocytosis | 22.21 | 9.96 | 81 | 329455 | 22104 | 46334422 |
| Respiratory distress | 22.20 | 9.96 | 133 | 329403 | 31783 | 46324743 |
| Fluid retention | 22.01 | 9.96 | 242 | 329294 | 50804 | 46305722 |
| Tenderness | 21.72 | 9.96 | 198 | 329338 | 16683 | 46339843 |
| Aspartate aminotransferase increased | 21.63 | 9.96 | 408 | 329128 | 78292 | 46278234 |
| Cyst | 21.61 | 9.96 | 153 | 329383 | 11947 | 46344579 |
| Placental disorder | 21.56 | 9.96 | 37 | 329499 | 1372 | 46355154 |
| Erythema multiforme | 21.51 | 9.96 | 22 | 329514 | 9682 | 46346844 |
| Thrombocytopenia | 21.50 | 9.96 | 705 | 328831 | 125876 | 46230650 |
| Melaena | 21.35 | 9.96 | 112 | 329424 | 27660 | 46328866 |
| Contusion | 21.18 | 9.96 | 786 | 328750 | 86701 | 46269825 |
| Fracture | 21.09 | 9.96 | 193 | 329343 | 16278 | 46340248 |
| Decreased appetite | 21.01 | 9.96 | 1136 | 328400 | 192700 | 46163826 |
| Eye infection | 21.00 | 9.96 | 123 | 329413 | 9000 | 46347526 |
| Transplant rejection | 21.00 | 9.96 | 22 | 329514 | 9574 | 46346952 |
| Foot fracture | 20.95 | 9.96 | 221 | 329315 | 19361 | 46337165 |
| Orthostatic hypotension | 20.94 | 9.96 | 96 | 329440 | 24562 | 46331964 |
| Inflammation | 20.90 | 9.96 | 471 | 329065 | 48310 | 46308216 |
| Hypermethioninaemia | 20.82 | 9.96 | 7 | 329529 | 12 | 46356514 |
| Alanine aminotransferase increased | 20.63 | 9.96 | 471 | 329065 | 87980 | 46268546 |
| Stress cardiomyopathy | 20.47 | 9.96 | 15 | 329521 | 7769 | 46348757 |
| Acute hepatic failure | 20.43 | 9.96 | 46 | 329490 | 14675 | 46341851 |
| Chest discomfort | 20.41 | 9.96 | 483 | 329053 | 89786 | 46266740 |
| Dry eye | 20.39 | 9.96 | 314 | 329222 | 30008 | 46326518 |
| Coagulopathy | 20.24 | 9.96 | 65 | 329471 | 18434 | 46338092 |
| Complication of device insertion | 20.18 | 9.96 | 5 | 329531 | 4939 | 46351587 |
| Immunodeficiency | 20.17 | 9.96 | 160 | 329376 | 12946 | 46343580 |
| Leukopenia | 20.13 | 9.96 | 350 | 329186 | 67993 | 46288533 |
| Rash | 20.12 | 9.96 | 2840 | 326696 | 353672 | 46002854 |
| Akathisia | 20.11 | 9.96 | 15 | 329521 | 7699 | 46348827 |
| Mouth ulceration | 20.06 | 9.96 | 283 | 329253 | 26549 | 46329977 |
| Clear cell renal cell carcinoma | 20.04 | 9.96 | 30 | 329506 | 989 | 46355537 |
| Brain oedema | 19.87 | 9.96 | 36 | 329500 | 12442 | 46344084 |
| Immunosuppression | 19.85 | 9.96 | 105 | 329431 | 7395 | 46349131 |
| Atrial septal defect | 19.84 | 9.96 | 93 | 329443 | 6239 | 46350287 |
| Face oedema | 19.79 | 9.96 | 69 | 329467 | 19084 | 46337442 |
| Deep vein thrombosis | 19.69 | 9.96 | 421 | 329115 | 79352 | 46277174 |
| Device dislocation | 19.65 | 9.96 | 83 | 329453 | 21719 | 46334807 |
| Drug intolerance | 19.65 | 9.96 | 1246 | 328290 | 145803 | 46210723 |
| Vitamin B6 increased | 19.65 | 9.96 | 6 | 329530 | 6 | 46356520 |
| Synovial fluid analysis | 19.53 | 9.96 | 35 | 329501 | 1344 | 46355182 |
| Diabetes mellitus inadequate control | 19.41 | 9.96 | 40 | 329496 | 13174 | 46343352 |
| Acute chest syndrome | 19.40 | 9.96 | 22 | 329514 | 548 | 46355978 |
| Respiratory disorder | 19.40 | 9.96 | 113 | 329423 | 27187 | 46329339 |
| Thrombotic microangiopathy | 19.38 | 9.96 | 18 | 329518 | 8288 | 46348238 |
| Blood glucose increased | 19.27 | 9.96 | 375 | 329161 | 71638 | 46284888 |
| Off label use | 19.19 | 9.96 | 2368 | 327168 | 377473 | 45979053 |
| Laryngitis | 19.16 | 9.96 | 122 | 329414 | 9194 | 46347332 |
| Serum ferritin increased | 19.13 | 9.96 | 81 | 329455 | 5202 | 46351324 |
| Blood alkaline phosphatase increased | 19.04 | 9.96 | 183 | 329353 | 39426 | 46317100 |
| Acute myeloid leukaemia | 19.02 | 9.96 | 53 | 329483 | 15725 | 46340801 |
| Hallucination, auditory | 19.02 | 9.96 | 29 | 329507 | 10727 | 46345799 |
| Injection site urticaria | 18.92 | 9.96 | 147 | 329389 | 11820 | 46344706 |
| Antinuclear antibody positive | 18.78 | 9.96 | 91 | 329445 | 6189 | 46350337 |
| Bronchospasm | 18.76 | 9.96 | 53 | 329483 | 15654 | 46340872 |
| Blood pressure decreased | 18.73 | 9.96 | 287 | 329249 | 56872 | 46299654 |
| Pulmonary hypertension | 18.73 | 9.96 | 163 | 329373 | 35830 | 46320696 |
| Acute graft versus host disease | 18.70 | 9.96 | 3 | 329533 | 4027 | 46352499 |
| Gamma-glutamyltransferase increased | 18.70 | 9.96 | 139 | 329397 | 31601 | 46324925 |
| Eosinophilia | 18.69 | 9.96 | 71 | 329465 | 19146 | 46337380 |
| Bone disorder | 18.66 | 9.96 | 220 | 329316 | 19813 | 46336713 |
| Blood bilirubin increased | 18.60 | 9.96 | 153 | 329383 | 34031 | 46322495 |
| Breast feeding | 18.58 | 9.96 | 27 | 329509 | 866 | 46355660 |
| Dysarthria | 18.56 | 9.96 | 172 | 329364 | 37326 | 46319200 |
| Hospitalisation | 18.55 | 9.96 | 325 | 329211 | 63060 | 46293466 |
| Disability | 18.42 | 9.96 | 129 | 329407 | 10038 | 46346488 |
| Nightmare | 18.39 | 9.96 | 58 | 329478 | 16540 | 46339986 |
| Schizophrenia | 18.35 | 9.96 | 20 | 329516 | 8548 | 46347978 |
| Graft versus host disease | 18.25 | 9.96 | 12 | 329524 | 6576 | 46349950 |
| Maternal exposure before pregnancy | 18.04 | 9.96 | 71 | 329465 | 4410 | 46352116 |
| Oedema | 18.03 | 9.96 | 349 | 329187 | 66722 | 46289804 |
| Body height below normal | 18.00 | 9.96 | 40 | 329496 | 1799 | 46354727 |
| Plasma cell myeloma | 17.95 | 9.96 | 214 | 329322 | 44264 | 46312262 |
| Joint injury | 17.91 | 9.96 | 211 | 329325 | 18998 | 46337528 |
| Aggression | 17.89 | 9.96 | 91 | 329445 | 22653 | 46333873 |
| Blood iron increased | 17.86 | 9.96 | 33 | 329503 | 1298 | 46355228 |
| Loose body in joint | 17.85 | 9.96 | 29 | 329507 | 1027 | 46355499 |
| Tooth infection | 17.84 | 9.96 | 148 | 329388 | 12138 | 46344388 |
| Cervical incompetence | 17.82 | 9.96 | 22 | 329514 | 601 | 46355925 |
| Neuroleptic malignant syndrome | 17.79 | 9.96 | 32 | 329504 | 11090 | 46345436 |
| Joint range of motion decreased | 17.77 | 9.96 | 174 | 329362 | 14950 | 46341576 |
| Pancreatitis acute | 17.64 | 9.96 | 103 | 329433 | 24769 | 46331757 |
| Polyarthritis | 17.60 | 9.96 | 92 | 329444 | 6450 | 46350076 |
| Congenital arterial malformation | 17.57 | 9.96 | 17 | 329519 | 350 | 46356176 |
| Mania | 17.54 | 9.96 | 31 | 329505 | 10815 | 46345711 |
| Chronic kidney disease | 17.52 | 9.96 | 194 | 329342 | 40677 | 46315849 |
| Carpal tunnel syndrome | 17.45 | 9.96 | 180 | 329356 | 15679 | 46340847 |
| Ischaemic stroke | 17.44 | 9.96 | 60 | 329476 | 16662 | 46339864 |
| Substance abuse | 17.43 | 9.96 | 4 | 329532 | 4163 | 46352363 |
| Injury | 17.32 | 9.96 | 213 | 329323 | 43814 | 46312712 |
| Miosis | 17.29 | 9.96 | 13 | 329523 | 6644 | 46349882 |
| Maternal exposure during breast feeding | 17.24 | 9.96 | 51 | 329485 | 2738 | 46353788 |
| Asphyxia | 17.22 | 9.96 | 8 | 329528 | 5318 | 46351208 |
| Knee operation | 17.20 | 9.96 | 73 | 329463 | 4693 | 46351833 |
| Injection site haematoma | 17.17 | 9.96 | 87 | 329449 | 6025 | 46350501 |
| Exomphalos | 17.00 | 9.96 | 20 | 329516 | 519 | 46356007 |
| Cholecystitis chronic | 16.98 | 9.96 | 30 | 329506 | 10469 | 46346057 |
| Viral infection | 16.98 | 9.96 | 304 | 329232 | 29931 | 46326595 |
| Pharyngitis streptococcal | 16.87 | 9.96 | 110 | 329426 | 8358 | 46348168 |
| Synovial disorder | 16.86 | 9.96 | 25 | 329511 | 817 | 46355709 |
| Pancytopenia | 16.85 | 9.96 | 748 | 328788 | 84310 | 46272216 |
| Device difficult to use | 16.79 | 9.96 | 19 | 329517 | 7985 | 46348541 |
| Disseminated tuberculosis | 16.70 | 9.96 | 50 | 329486 | 2702 | 46353824 |
| Jaundice | 16.67 | 9.96 | 127 | 329409 | 28718 | 46327808 |
| Poor venous access | 16.60 | 9.96 | 108 | 329428 | 8200 | 46348326 |
| Stillbirth | 16.58 | 9.96 | 90 | 329446 | 6401 | 46350125 |
| Wheelchair user | 16.54 | 9.96 | 64 | 329472 | 3944 | 46352582 |
| Weight decreased | 16.53 | 9.96 | 1715 | 327821 | 209134 | 46147392 |
| Rotator cuff repair | 16.46 | 9.96 | 34 | 329502 | 1453 | 46355073 |
| Rash maculo-papular | 16.45 | 9.96 | 122 | 329414 | 27752 | 46328774 |
| Bradyphrenia | 16.39 | 9.96 | 12 | 329524 | 6218 | 46350308 |
| Cytokine release syndrome | 16.36 | 9.96 | 12 | 329524 | 6211 | 46350315 |
| Cystitis | 16.30 | 9.96 | 402 | 329134 | 41839 | 46314687 |
| Anhedonia | 16.30 | 9.96 | 30 | 329506 | 10305 | 46346221 |
| Induced labour | 16.27 | 9.96 | 26 | 329510 | 908 | 46355618 |
| Rhinorrhoea | 16.18 | 9.96 | 446 | 329090 | 47219 | 46309307 |
| Haemorrhage | 16.16 | 9.96 | 281 | 329255 | 54588 | 46301938 |
| Toxic skin eruption | 16.16 | 9.96 | 40 | 329496 | 12347 | 46344179 |
| Ketoacidosis | 16.15 | 9.96 | 4 | 329532 | 3951 | 46352575 |
| Pain in jaw | 16.11 | 9.96 | 183 | 329353 | 38189 | 46318337 |
| Spinal stenosis | 16.07 | 9.96 | 147 | 329389 | 12396 | 46344130 |
| Bone density abnormal | 15.93 | 9.96 | 53 | 329483 | 3031 | 46353495 |
| Device use error | 15.86 | 9.96 | 8 | 329528 | 5073 | 46351453 |
| Blood creatinine increased | 15.86 | 9.96 | 414 | 329122 | 75989 | 46280537 |
| Joint noise | 15.78 | 9.96 | 54 | 329482 | 3133 | 46353393 |
| Depression | 15.72 | 9.96 | 1012 | 328524 | 169092 | 46187434 |
| Injection site haemorrhage | 15.72 | 9.96 | 219 | 329317 | 20490 | 46336036 |
| Second primary malignancy | 15.68 | 9.96 | 14 | 329522 | 6570 | 46349956 |
| Dehydration | 15.64 | 9.96 | 944 | 328592 | 158596 | 46197930 |
| Fear | 15.57 | 9.96 | 60 | 329476 | 16112 | 46340414 |
| Tooth disorder | 15.55 | 9.96 | 241 | 329295 | 23062 | 46333464 |
| Pathogen resistance | 15.52 | 9.96 | 12 | 329524 | 6048 | 46350478 |
| Foetal distress syndrome | 15.49 | 9.96 | 30 | 329506 | 1223 | 46355303 |
| Pulmonary fibrosis | 15.46 | 9.96 | 213 | 329323 | 19879 | 46336647 |
| Cognitive disorder | 15.45 | 9.96 | 176 | 329360 | 36707 | 46319819 |
| Diverticulitis | 15.43 | 9.96 | 323 | 329213 | 32716 | 46323810 |
| Tumour lysis syndrome | 15.38 | 9.96 | 17 | 329519 | 7219 | 46349307 |
| Tachypnoea | 15.30 | 9.96 | 51 | 329485 | 14300 | 46342226 |
| Ascites | 15.15 | 9.96 | 175 | 329361 | 36409 | 46320117 |
| Neurotoxicity | 15.15 | 9.96 | 48 | 329488 | 13669 | 46342857 |
| Hypomania | 15.13 | 9.96 | 6 | 329530 | 4382 | 46352144 |
| Scleritis | 15.00 | 9.96 | 50 | 329486 | 2862 | 46353664 |
| Hypersensitivity | 14.99 | 9.96 | 1244 | 328292 | 149077 | 46207449 |
| Diarrhoea | 14.98 | 9.96 | 3613 | 325923 | 555989 | 45800537 |
| Arthritis bacterial | 14.97 | 9.96 | 80 | 329456 | 5656 | 46350870 |
| Injection site irritation | 14.96 | 9.96 | 65 | 329471 | 4222 | 46352304 |
| Muscle spasticity | 14.88 | 9.96 | 37 | 329499 | 11403 | 46345123 |
| Naevus flammeus | 14.80 | 9.96 | 10 | 329526 | 120 | 46356406 |
| Renal injury | 14.77 | 9.96 | 28 | 329508 | 9513 | 46347013 |
| Antibody test positive | 14.75 | 9.96 | 41 | 329495 | 2124 | 46354402 |
| Morning sickness | 14.65 | 9.96 | 21 | 329515 | 665 | 46355861 |
| Limb injury | 14.65 | 9.96 | 203 | 329333 | 18971 | 46337555 |
| Pulmonary oedema | 14.64 | 9.96 | 263 | 329273 | 50842 | 46305684 |
| Post procedural infection | 14.61 | 9.96 | 97 | 329439 | 7416 | 46349110 |
| Vertigo | 14.55 | 9.96 | 269 | 329267 | 51779 | 46304747 |
| Fracture delayed union | 14.55 | 9.96 | 41 | 329495 | 2141 | 46354385 |
| Shock haemorrhagic | 14.54 | 9.96 | 24 | 329512 | 8600 | 46347926 |
| Cardiogenic shock | 14.39 | 9.96 | 63 | 329473 | 16321 | 46340205 |
| Human antichimeric antibody positive | 14.39 | 9.96 | 31 | 329505 | 1365 | 46355161 |
| Cerebrovascular accident | 14.38 | 9.96 | 575 | 328961 | 100464 | 46256062 |
| Sedation complication | 14.28 | 9.96 | 4 | 329532 | 3641 | 46352885 |
| Palpitations | 14.23 | 9.96 | 539 | 328997 | 94720 | 46261806 |
| Ear infection | 14.23 | 9.96 | 235 | 329301 | 22778 | 46333748 |
| Talipes | 14.22 | 9.96 | 31 | 329505 | 1376 | 46355150 |
| Stevens-Johnson syndrome | 14.22 | 9.96 | 101 | 329435 | 23196 | 46333330 |
| Tubulointerstitial nephritis | 14.15 | 9.96 | 55 | 329481 | 14733 | 46341793 |
| Cushingoid | 14.11 | 9.96 | 84 | 329452 | 6182 | 46350344 |
| Cholestasis of pregnancy | 14.00 | 9.96 | 27 | 329509 | 1097 | 46355429 |
| Haematotoxicity | 13.96 | 9.96 | 17 | 329519 | 6916 | 46349610 |
| Bursitis | 13.93 | 9.96 | 207 | 329329 | 19635 | 46336891 |
| Premature baby | 13.93 | 9.96 | 192 | 329344 | 17920 | 46338606 |
| Joint lock | 13.89 | 9.96 | 39 | 329497 | 2032 | 46354494 |
| Hyperuricaemia | 13.89 | 9.96 | 8 | 329528 | 4709 | 46351817 |
| Carcinoma in situ of skin | 13.81 | 9.96 | 12 | 329524 | 214 | 46356312 |
| Myopathy | 13.81 | 9.96 | 26 | 329510 | 8855 | 46347671 |
| Arthropod sting | 13.79 | 9.96 | 23 | 329513 | 833 | 46355693 |
| Complication associated with device | 13.79 | 9.96 | 59 | 329477 | 15382 | 46341144 |
| Aspergillus infection | 13.77 | 9.96 | 17 | 329519 | 6873 | 46349653 |
| Upper respiratory tract infection | 13.73 | 9.96 | 564 | 328972 | 62992 | 46293534 |
| Crying | 13.72 | 9.96 | 90 | 329446 | 21051 | 46335475 |
| Cartilage injury | 13.72 | 9.96 | 33 | 329503 | 1564 | 46354962 |
| Haemorrhage intracranial | 13.72 | 9.96 | 45 | 329491 | 12679 | 46343847 |
| Frequent bowel movements | 13.72 | 9.96 | 143 | 329393 | 12489 | 46344037 |
| Transplant dysfunction | 13.70 | 9.96 | 8 | 329528 | 4674 | 46351852 |
| Pemphigoid | 13.67 | 9.96 | 12 | 329524 | 5679 | 46350847 |
| Lip swelling | 13.66 | 9.96 | 114 | 329422 | 25281 | 46331245 |
| Pancreatitis | 13.64 | 9.96 | 221 | 329315 | 43406 | 46313120 |
| Lung neoplasm | 13.61 | 9.96 | 78 | 329458 | 5662 | 46350864 |
| Pyrexia | 13.57 | 9.96 | 2209 | 327327 | 346593 | 46009933 |
| Catheter site pain | 13.46 | 9.96 | 5 | 329531 | 3801 | 46352725 |
| Delivery | 13.41 | 9.96 | 20 | 329516 | 657 | 46355869 |
| Polyneuropathy | 13.39 | 9.96 | 40 | 329496 | 11604 | 46344922 |
| Pleural effusion | 13.38 | 9.96 | 465 | 329071 | 82487 | 46274039 |
| Haemophagocytic lymphohistiocytosis | 13.35 | 9.96 | 24 | 329512 | 8318 | 46348208 |
| Genital haemorrhage | 13.33 | 9.96 | 16 | 329520 | 6550 | 46349976 |
| Fluid overload | 13.32 | 9.96 | 125 | 329411 | 27060 | 46329466 |
| Oliguria | 13.31 | 9.96 | 26 | 329510 | 8733 | 46347793 |
| Haemorrhage in pregnancy | 13.30 | 9.96 | 33 | 329503 | 1595 | 46354931 |
| Colitis microscopic | 13.29 | 9.96 | 16 | 329520 | 6540 | 46349986 |
| Hiatus hernia | 13.27 | 9.96 | 192 | 329344 | 18110 | 46338416 |
| Atrial fibrillation | 13.17 | 9.96 | 597 | 328939 | 102993 | 46253533 |
| Medication error | 13.14 | 9.96 | 147 | 329389 | 30764 | 46325762 |
| Gastroenteritis | 13.07 | 9.96 | 242 | 329294 | 23977 | 46332549 |
| Lymphadenectomy | 13.02 | 9.96 | 23 | 329513 | 873 | 46355653 |
| Cerebral infarction | 12.98 | 9.96 | 104 | 329432 | 23262 | 46333264 |
| Feeling abnormal | 12.97 | 9.96 | 736 | 328800 | 124324 | 46232202 |
| Dactylitis | 12.88 | 9.96 | 27 | 329509 | 1166 | 46355360 |
| Lupus-like syndrome | 12.76 | 9.96 | 97 | 329439 | 7747 | 46348779 |
| Hallucination, visual | 12.69 | 9.96 | 74 | 329462 | 17799 | 46338727 |
| Cytomegalovirus viraemia | 12.62 | 9.96 | 8 | 329528 | 4470 | 46352056 |
| Lymph node tuberculosis | 12.58 | 9.96 | 21 | 329515 | 761 | 46355765 |
| Ingrown hair | 12.55 | 9.96 | 16 | 329520 | 452 | 46356074 |
| Cyanosis | 12.50 | 9.96 | 64 | 329472 | 15907 | 46340619 |
| Sickle cell anaemia | 12.47 | 9.96 | 18 | 329518 | 574 | 46355952 |
| Haematocrit decreased | 12.46 | 9.96 | 330 | 329206 | 34727 | 46321799 |
| Acidosis | 12.41 | 9.96 | 39 | 329497 | 11135 | 46345391 |
| Atrioventricular block | 12.39 | 9.96 | 18 | 329518 | 6793 | 46349733 |
| Body temperature decreased | 12.37 | 9.96 | 147 | 329389 | 13262 | 46343264 |
| Dysgeusia | 12.36 | 9.96 | 206 | 329330 | 40285 | 46316241 |
| Vision blurred | 12.35 | 9.96 | 449 | 329087 | 79259 | 46277267 |
| Joint dislocation | 12.32 | 9.96 | 127 | 329409 | 11059 | 46345467 |
| Uterine contractions during pregnancy | 12.28 | 9.96 | 17 | 329519 | 521 | 46356005 |
| Cardiac failure acute | 12.25 | 9.96 | 24 | 329512 | 8054 | 46348472 |
| Sinus congestion | 12.22 | 9.96 | 144 | 329392 | 12965 | 46343561 |
| Skin laceration | 12.21 | 9.96 | 191 | 329345 | 18311 | 46338215 |
| Infusion site pain | 12.15 | 9.96 | 34 | 329502 | 10073 | 46346453 |
| Circulatory collapse | 12.12 | 9.96 | 96 | 329440 | 21528 | 46334998 |
| Myoclonus | 12.11 | 9.96 | 56 | 329480 | 14296 | 46342230 |
| Accidental exposure to product | 12.10 | 9.96 | 93 | 329443 | 20988 | 46335538 |
| Wrong technique in product usage process | 12.07 | 9.96 | 292 | 329244 | 54130 | 46302396 |
| Tinea pedis | 11.93 | 9.96 | 29 | 329507 | 1384 | 46355142 |
| VIth nerve disorder | 11.88 | 9.96 | 3 | 329533 | 0 | 46356526 |
| CSF oligoclonal band | 11.88 | 9.96 | 3 | 329533 | 0 | 46356526 |
| Withdrawal syndrome | 11.87 | 9.96 | 77 | 329459 | 18057 | 46338469 |
| Hypomagnesaemia | 11.81 | 9.96 | 100 | 329436 | 22110 | 46334416 |
| Tardive dyskinesia | 11.80 | 9.96 | 22 | 329514 | 7521 | 46349005 |
| Joint warmth | 11.78 | 9.96 | 27 | 329509 | 1240 | 46355286 |
| Delusion | 11.77 | 9.96 | 40 | 329496 | 11148 | 46345378 |
| Anaemia | 11.74 | 9.96 | 1604 | 327932 | 254175 | 46102351 |
| Anterior chamber cleavage syndrome | 11.71 | 9.96 | 10 | 329526 | 174 | 46356352 |
| Breech presentation | 11.69 | 9.96 | 25 | 329511 | 1095 | 46355431 |
| Intervertebral disc degeneration | 11.67 | 9.96 | 144 | 329392 | 13108 | 46343418 |
| Injection site extravasation | 11.66 | 9.96 | 85 | 329451 | 6700 | 46349826 |
| Chest pain | 11.58 | 9.96 | 1079 | 328457 | 175245 | 46181281 |
| Diabetes mellitus | 11.55 | 9.96 | 267 | 329269 | 49798 | 46306728 |
| Incorrect route of product administration | 11.54 | 9.96 | 68 | 329468 | 16315 | 46340211 |
| Tonsillitis | 11.47 | 9.96 | 67 | 329469 | 4897 | 46351629 |
| Catheter site erythema | 11.38 | 9.96 | 7 | 329529 | 3976 | 46352550 |
| Infusion site erythema | 11.34 | 9.96 | 23 | 329513 | 7619 | 46348907 |
| Meningitis tuberculous | 11.32 | 9.96 | 17 | 329519 | 562 | 46355964 |
| Foetal anticonvulsant syndrome | 11.31 | 9.96 | 15 | 329521 | 441 | 46356085 |
| Forceps delivery | 11.30 | 9.96 | 10 | 329526 | 183 | 46356343 |
| Autism spectrum disorder | 11.25 | 9.96 | 17 | 329519 | 565 | 46355961 |
| Product adhesion issue | 11.25 | 9.96 | 11 | 329525 | 4944 | 46351582 |
| Complication of pregnancy | 11.25 | 9.96 | 16 | 329520 | 503 | 46356023 |
| Labelled drug-drug interaction medication error | 11.25 | 9.96 | 30 | 329506 | 9031 | 46347495 |
| Postpartum haemorrhage | 11.24 | 9.96 | 33 | 329503 | 1764 | 46354762 |
| Failed induction of labour | 11.21 | 9.96 | 13 | 329523 | 332 | 46356194 |
| Tenosynovitis | 11.16 | 9.96 | 91 | 329445 | 7424 | 46349102 |
| Pancreatic steatosis | 11.15 | 9.96 | 23 | 329513 | 982 | 46355544 |
| C-reactive protein increased | 11.11 | 9.96 | 513 | 329023 | 58077 | 46298449 |
| Hypoglycaemia neonatal | 11.04 | 9.96 | 22 | 329514 | 916 | 46355610 |
| Injection site induration | 11.03 | 9.96 | 96 | 329440 | 7983 | 46348543 |
| Trichophytosis | 11.02 | 9.96 | 6 | 329530 | 47 | 46356479 |
| Intestinal stenosis | 11.02 | 9.96 | 41 | 329495 | 2480 | 46354046 |
| Red blood cell count decreased | 11.00 | 9.96 | 305 | 329231 | 32318 | 46324208 |
| Human anti-human antibody test | 11.00 | 9.96 | 13 | 329523 | 339 | 46356187 |
| Cold type haemolytic anaemia | 10.99 | 9.96 | 10 | 329526 | 190 | 46356336 |
| Creatinine renal clearance decreased | 10.99 | 9.96 | 20 | 329516 | 6900 | 46349626 |
| Pulmonary alveolar haemorrhage | 10.97 | 9.96 | 8 | 329528 | 4154 | 46352372 |
| Vacuum extractor delivery | 10.96 | 9.96 | 9 | 329527 | 148 | 46356378 |
| Abortion missed | 10.94 | 9.96 | 30 | 329506 | 1542 | 46354984 |
| Obstructive airways disorder | 10.93 | 9.96 | 53 | 329483 | 13359 | 46343167 |
| Placental insufficiency | 10.90 | 9.96 | 27 | 329509 | 1304 | 46355222 |
| Multiple sclerosis | 10.90 | 9.96 | 117 | 329419 | 24674 | 46331852 |
| Parkinsonism | 10.90 | 9.96 | 25 | 329511 | 7923 | 46348603 |
| Coronary artery disease | 10.88 | 9.96 | 170 | 329366 | 33582 | 46322944 |
| Mycobacterium tuberculosis complex test positive | 10.86 | 9.96 | 30 | 329506 | 1548 | 46354978 |
| Preterm premature rupture of membranes | 10.84 | 9.96 | 23 | 329513 | 1002 | 46355524 |
| Upper respiratory tract irritation | 10.82 | 9.96 | 6 | 329530 | 49 | 46356477 |
| Cardiomyopathy | 10.65 | 9.96 | 68 | 329468 | 16005 | 46340521 |
| Polychondritis | 10.65 | 9.96 | 14 | 329522 | 408 | 46356118 |
| Gastrointestinal haemorrhage | 10.65 | 9.96 | 442 | 329094 | 76931 | 46279595 |
| Tendon disorder | 10.64 | 9.96 | 66 | 329470 | 4929 | 46351597 |
| Anuria | 10.63 | 9.96 | 43 | 329493 | 11388 | 46345138 |
| Lymphoma | 10.61 | 9.96 | 111 | 329425 | 9702 | 46346824 |
| Metastases to central nervous system | 10.56 | 9.96 | 42 | 329494 | 11179 | 46345347 |
| Red blood cell sedimentation rate | 10.56 | 9.96 | 32 | 329504 | 1741 | 46354785 |
| Endodontic procedure | 10.52 | 9.96 | 40 | 329496 | 2445 | 46354081 |
| Crystal nephropathy | 10.50 | 9.96 | 20 | 329516 | 805 | 46355721 |
| Lymphatic fistula | 10.49 | 9.96 | 21 | 329515 | 877 | 46355649 |
| Nail injury | 10.46 | 9.96 | 14 | 329522 | 415 | 46356111 |
| Mass | 10.42 | 9.96 | 127 | 329409 | 11526 | 46345000 |
| Abortion incomplete | 10.40 | 9.96 | 5 | 329531 | 3259 | 46353267 |
| Animal bite | 10.39 | 9.96 | 38 | 329498 | 2279 | 46354247 |
| Platelet count increased | 10.38 | 9.96 | 155 | 329381 | 14719 | 46341807 |
| Disease recurrence | 10.36 | 9.96 | 82 | 329454 | 18389 | 46338137 |
| Wound infection pseudomonas | 10.35 | 9.96 | 28 | 329508 | 1427 | 46355099 |
| Dysphagia | 10.35 | 9.96 | 443 | 329093 | 76869 | 46279657 |
| Product complaint | 10.34 | 9.96 | 47 | 329489 | 12054 | 46344472 |
| Photophobia | 10.32 | 9.96 | 152 | 329384 | 14392 | 46342134 |
| Femoral hernia incarcerated | 10.32 | 9.96 | 21 | 329515 | 888 | 46355638 |
| Hypervitaminosis | 10.29 | 9.96 | 5 | 329531 | 30 | 46356496 |
| Aortic embolus | 10.29 | 9.96 | 5 | 329531 | 30 | 46356496 |
| Pulseless electrical activity | 10.27 | 9.96 | 22 | 329514 | 7145 | 46349381 |
| Dyskinesia | 10.25 | 9.96 | 143 | 329393 | 28782 | 46327744 |
| Pleuritic pain | 10.25 | 9.96 | 79 | 329457 | 6337 | 46350189 |
| Hypophosphataemia | 10.24 | 9.96 | 23 | 329513 | 7344 | 46349182 |
| Muscle rupture | 10.24 | 9.96 | 35 | 329501 | 2030 | 46354496 |
| Drug abuser | 10.23 | 9.96 | 5 | 329531 | 3228 | 46353298 |
| Normal newborn | 10.21 | 9.96 | 75 | 329461 | 5926 | 46350600 |
| Cytopenia | 10.20 | 9.96 | 25 | 329511 | 7743 | 46348783 |
| Ulcer | 10.17 | 9.96 | 176 | 329360 | 17216 | 46339310 |
| Tooth abscess | 10.16 | 9.96 | 135 | 329401 | 12498 | 46344028 |
| Aphonia | 10.12 | 9.96 | 93 | 329443 | 7852 | 46348674 |
| Hyperprolactinaemia | 10.12 | 9.96 | 4 | 329532 | 2928 | 46353598 |
| Bite | 10.09 | 9.96 | 13 | 329523 | 371 | 46356155 |
| Drug ineffective for unapproved indication | 10.09 | 9.96 | 71 | 329465 | 16342 | 46340184 |
| Neonatal respiratory distress syndrome | 10.09 | 9.96 | 40 | 329496 | 2493 | 46354033 |
| Bone contusion | 10.08 | 9.96 | 20 | 329516 | 830 | 46355696 |
| Inflammatory bowel disease | 9.99 | 9.96 | 47 | 329489 | 3158 | 46353368 |
| Angina pectoris | 9.99 | 9.96 | 131 | 329405 | 26644 | 46329882 |
| Oedema peripheral | 9.97 | 9.96 | 981 | 328555 | 158725 | 46197801 |
| Stress at work | 9.96 | 9.96 | 22 | 329514 | 985 | 46355541 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Rheumatoid arthritis | 380.86 | 10.19 | 712 | 148185 | 40485 | 29763096 |
| Drug abuse | 331.23 | 10.19 | 19 | 148878 | 82053 | 29721528 |
| Completed suicide | 243.39 | 10.19 | 95 | 148802 | 99397 | 29704184 |
| Toxicity to various agents | 231.81 | 10.19 | 326 | 148571 | 176857 | 29626724 |
| Foetal exposure during pregnancy | 189.44 | 10.19 | 504 | 148393 | 36367 | 29767214 |
| Arthralgia | 181.68 | 10.19 | 1226 | 147671 | 134565 | 29669016 |
| Psoriatic arthropathy | 101.56 | 10.19 | 235 | 148662 | 15526 | 29788055 |
| Drug interaction | 98.65 | 10.19 | 585 | 148312 | 198983 | 29604598 |
| Sickle cell anaemia with crisis | 89.89 | 10.19 | 83 | 148814 | 2319 | 29801262 |
| Premature baby | 84.50 | 10.19 | 227 | 148670 | 16464 | 29787117 |
| Joint swelling | 80.33 | 10.19 | 452 | 148445 | 46494 | 29757087 |
| Intentional overdose | 72.21 | 10.19 | 60 | 148837 | 41421 | 29762160 |
| Overdose | 70.64 | 10.19 | 201 | 148696 | 84136 | 29719445 |
| Exposure during pregnancy | 69.74 | 10.19 | 147 | 148750 | 9114 | 29794467 |
| Neonatal respiratory distress syndrome | 67.09 | 10.19 | 91 | 148806 | 3921 | 29799660 |
| Nasopharyngitis | 63.95 | 10.19 | 506 | 148391 | 58343 | 29745238 |
| Enthesopathy | 62.99 | 10.19 | 75 | 148822 | 2831 | 29800750 |
| Atrial septal defect | 60.82 | 10.19 | 115 | 148782 | 6586 | 29796995 |
| Tenosynovitis | 60.72 | 10.19 | 81 | 148816 | 3434 | 29800147 |
| Acute kidney injury | 59.39 | 10.19 | 981 | 147916 | 272861 | 29530720 |
| Tuberculosis | 57.13 | 10.19 | 125 | 148772 | 7952 | 29795629 |
| Blood pressure fluctuation | 54.35 | 10.19 | 201 | 148696 | 17302 | 29786279 |
| Death | 52.58 | 10.19 | 1364 | 147533 | 355919 | 29447662 |
| Maternal drugs affecting foetus | 51.37 | 10.19 | 83 | 148814 | 4190 | 29799391 |
| Hypospadias | 51.37 | 10.19 | 65 | 148832 | 2614 | 29800967 |
| Musculoskeletal stiffness | 50.86 | 10.19 | 329 | 148568 | 35552 | 29768029 |
| Drug reaction with eosinophilia and systemic symptoms | 48.60 | 10.19 | 42 | 148855 | 28446 | 29775135 |
| Haemoglobin decreased | 48.56 | 10.19 | 817 | 148080 | 113281 | 29690300 |
| Low birth weight baby | 46.39 | 10.19 | 97 | 148800 | 5979 | 29797602 |
| Hepatic function abnormal | 45.52 | 10.19 | 87 | 148810 | 41858 | 29761723 |
| Small for dates baby | 43.70 | 10.19 | 66 | 148831 | 3142 | 29800439 |
| Maternal exposure during breast feeding | 43.68 | 10.19 | 47 | 148850 | 1585 | 29801996 |
| Maternal exposure during pregnancy | 43.58 | 10.19 | 73 | 148824 | 3798 | 29799783 |
| Respiratory arrest | 43.17 | 10.19 | 49 | 148848 | 29209 | 29774372 |
| Suicide attempt | 42.61 | 10.19 | 73 | 148824 | 36624 | 29766957 |
| Febrile neutropenia | 42.52 | 10.19 | 333 | 148564 | 106360 | 29697221 |
| Rhabdomyolysis | 41.97 | 10.19 | 168 | 148729 | 63412 | 29740169 |
| Synovitis | 40.72 | 10.19 | 124 | 148773 | 9659 | 29793922 |
| Intentional product misuse | 40.21 | 10.19 | 69 | 148828 | 34598 | 29768983 |
| Hypoglycaemia neonatal | 39.61 | 10.19 | 44 | 148853 | 1539 | 29802042 |
| Dysmorphism | 38.77 | 10.19 | 49 | 148848 | 1968 | 29801613 |
| Tongue disorder | 37.78 | 10.19 | 73 | 148824 | 4249 | 29799332 |
| Ventricular septal defect | 37.68 | 10.19 | 65 | 148832 | 3464 | 29800117 |
| Product use in unapproved indication | 36.84 | 10.19 | 215 | 148682 | 73478 | 29730103 |
| Cardiac arrest | 35.97 | 10.19 | 292 | 148605 | 92558 | 29711023 |
| Cryptorchism | 35.88 | 10.19 | 43 | 148854 | 1634 | 29801947 |
| Coma | 35.64 | 10.19 | 94 | 148803 | 40355 | 29763226 |
| Pain | 35.29 | 10.19 | 1115 | 147782 | 171526 | 29632055 |
| Cardiac failure | 35.29 | 10.19 | 256 | 148641 | 83162 | 29720419 |
| Drug withdrawal syndrome | 35.28 | 10.19 | 28 | 148869 | 19781 | 29783800 |
| Serotonin syndrome | 34.85 | 10.19 | 23 | 148874 | 17868 | 29785713 |
| Infusion related reaction | 34.25 | 10.19 | 330 | 148567 | 40234 | 29763347 |
| Arthritis | 34.12 | 10.19 | 223 | 148674 | 24178 | 29779403 |
| Pancytopenia | 33.63 | 10.19 | 602 | 148295 | 84450 | 29719131 |
| Psoriasis | 33.56 | 10.19 | 341 | 148556 | 42165 | 29761416 |
| C-reactive protein abnormal | 33.43 | 10.19 | 81 | 148816 | 5512 | 29798069 |
| Angioedema | 33.36 | 10.19 | 76 | 148821 | 34308 | 29769273 |
| Syndactyly | 32.58 | 10.19 | 28 | 148869 | 710 | 29802871 |
| Basal cell carcinoma | 32.45 | 10.19 | 162 | 148735 | 15906 | 29787675 |
| Peripheral swelling | 32.36 | 10.19 | 454 | 148443 | 60620 | 29742961 |
| Drug dependence | 32.14 | 10.19 | 35 | 148862 | 21260 | 29782321 |
| Lower respiratory tract infection | 31.96 | 10.19 | 235 | 148662 | 26479 | 29777102 |
| Blood pressure systolic increased | 31.70 | 10.19 | 154 | 148743 | 14956 | 29788625 |
| Arthropathy | 31.19 | 10.19 | 193 | 148704 | 20534 | 29783047 |
| Poisoning | 31.04 | 10.19 | 9 | 148888 | 11373 | 29792208 |
| Pulmonary fibrosis | 30.55 | 10.19 | 158 | 148739 | 15732 | 29787849 |
| Large for dates baby | 30.51 | 10.19 | 29 | 148868 | 841 | 29802740 |
| Drug intolerance | 30.06 | 10.19 | 351 | 148546 | 44940 | 29758641 |
| Exposure via breast milk | 29.92 | 10.19 | 38 | 148859 | 1534 | 29802047 |
| Delirium | 29.65 | 10.19 | 103 | 148794 | 40528 | 29763053 |
| Bradycardia | 28.73 | 10.19 | 199 | 148698 | 65327 | 29738254 |
| Drug resistance | 28.33 | 10.19 | 35 | 148862 | 20098 | 29783483 |
| Osteoarthritis | 27.70 | 10.19 | 171 | 148726 | 18178 | 29785403 |
| Foetal anticonvulsant syndrome | 27.53 | 10.19 | 26 | 148871 | 748 | 29802833 |
| Loss of personal independence in daily activities | 27.24 | 10.19 | 192 | 148705 | 21343 | 29782238 |
| Cytomegalovirus infection | 26.66 | 10.19 | 48 | 148849 | 23626 | 29779955 |
| Alanine aminotransferase abnormal | 26.36 | 10.19 | 47 | 148850 | 2572 | 29801009 |
| Renal failure | 25.91 | 10.19 | 468 | 148429 | 128498 | 29675083 |
| Pulmonary tuberculosis | 25.53 | 10.19 | 67 | 148830 | 4790 | 29798791 |
| Shock | 25.16 | 10.19 | 47 | 148850 | 22812 | 29780769 |
| Musculoskeletal pain | 24.80 | 10.19 | 249 | 148648 | 30691 | 29772890 |
| Hyperglycaemia | 24.51 | 10.19 | 91 | 148806 | 35109 | 29768472 |
| Weight decreased | 24.40 | 10.19 | 949 | 147948 | 149972 | 29653609 |
| Skin cancer | 24.36 | 10.19 | 91 | 148806 | 7870 | 29795711 |
| Agitation | 24.30 | 10.19 | 163 | 148734 | 53910 | 29749671 |
| Blood pressure systolic abnormal | 23.42 | 10.19 | 33 | 148864 | 1474 | 29802107 |
| Congenital hand malformation | 23.30 | 10.19 | 19 | 148878 | 447 | 29803134 |
| Pain in extremity | 23.05 | 10.19 | 714 | 148183 | 109507 | 29694074 |
| Medical device implantation | 23.01 | 10.19 | 20 | 148877 | 515 | 29803066 |
| Hypoglycaemia | 22.75 | 10.19 | 154 | 148743 | 50827 | 29752754 |
| Juvenile idiopathic arthritis | 22.74 | 10.19 | 27 | 148870 | 1016 | 29802565 |
| Pathogen resistance | 22.30 | 10.19 | 7 | 148890 | 8403 | 29795178 |
| Renal impairment | 22.18 | 10.19 | 290 | 148607 | 83894 | 29719687 |
| Knee arthroplasty | 22.17 | 10.19 | 70 | 148827 | 5560 | 29798021 |
| Body temperature decreased | 22.15 | 10.19 | 101 | 148796 | 9554 | 29794027 |
| Selective eating disorder | 22.03 | 10.19 | 34 | 148863 | 1650 | 29801931 |
| Rheumatoid nodule | 21.94 | 10.19 | 34 | 148863 | 1656 | 29801925 |
| Intentional self-injury | 21.83 | 10.19 | 21 | 148876 | 13511 | 29790070 |
| Tendonitis | 21.46 | 10.19 | 88 | 148809 | 7948 | 29795633 |
| Suicidal ideation | 21.03 | 10.19 | 100 | 148797 | 36014 | 29767567 |
| Arthritis bacterial | 20.89 | 10.19 | 59 | 148838 | 4405 | 29799176 |
| Bradycardia neonatal | 20.45 | 10.19 | 24 | 148873 | 892 | 29802689 |
| Substance abuse | 20.27 | 10.19 | 5 | 148892 | 7035 | 29796546 |
| Serum ferritin increased | 19.96 | 10.19 | 66 | 148831 | 5371 | 29798210 |
| Aggression | 19.89 | 10.19 | 105 | 148792 | 36802 | 29766779 |
| Agitation neonatal | 19.86 | 10.19 | 25 | 148872 | 1000 | 29802581 |
| Blood pressure increased | 19.86 | 10.19 | 483 | 148414 | 71445 | 29732136 |
| Caesarean section | 19.80 | 10.19 | 37 | 148860 | 2100 | 29801481 |
| Hepatic cyst | 19.66 | 10.19 | 40 | 148857 | 2418 | 29801163 |
| Neuroleptic malignant syndrome | 19.29 | 10.19 | 32 | 148865 | 16263 | 29787318 |
| Blood creatine phosphokinase increased | 19.29 | 10.19 | 133 | 148764 | 43715 | 29759866 |
| Injection site pain | 19.27 | 10.19 | 233 | 148664 | 30077 | 29773504 |
| Somnolence | 19.15 | 10.19 | 352 | 148545 | 96411 | 29707170 |
| Pneumonia | 19.02 | 10.19 | 1918 | 146979 | 332388 | 29471193 |
| Red blood cell count decreased | 18.82 | 10.19 | 207 | 148690 | 26114 | 29777467 |
| Appendicolith | 18.75 | 10.19 | 23 | 148874 | 896 | 29802685 |
| Jaundice neonatal | 18.52 | 10.19 | 25 | 148872 | 1072 | 29802509 |
| Low set ears | 18.51 | 10.19 | 16 | 148881 | 409 | 29803172 |
| Foetal growth restriction | 18.38 | 10.19 | 49 | 148848 | 3536 | 29800045 |
| Anal atresia | 18.20 | 10.19 | 14 | 148883 | 302 | 29803279 |
| Infective pulmonary exacerbation of cystic fibrosis | 18.12 | 10.19 | 10 | 148887 | 8562 | 29795019 |
| Talipes | 18.08 | 10.19 | 31 | 148866 | 1644 | 29801937 |
| Hand deformity | 18.07 | 10.19 | 33 | 148864 | 1840 | 29801741 |
| Neck mass | 18.02 | 10.19 | 28 | 148869 | 1367 | 29802214 |
| Back disorder | 17.91 | 10.19 | 68 | 148829 | 5926 | 29797655 |
| Asthma | 17.82 | 10.19 | 106 | 148791 | 36068 | 29767513 |
| Depressed level of consciousness | 17.79 | 10.19 | 114 | 148783 | 38108 | 29765473 |
| Back pain | 17.73 | 10.19 | 650 | 148247 | 101946 | 29701635 |
| Cellulitis | 17.72 | 10.19 | 329 | 148568 | 46455 | 29757126 |
| Neuropathy peripheral | 17.61 | 10.19 | 467 | 148430 | 70008 | 29733573 |
| Lacrimal disorder | 17.58 | 10.19 | 14 | 148883 | 318 | 29803263 |
| Cleft lip | 17.55 | 10.19 | 14 | 148883 | 319 | 29803262 |
| Haemangioma congenital | 17.44 | 10.19 | 17 | 148880 | 509 | 29803072 |
| Vitamin D deficiency | 17.43 | 10.19 | 61 | 148836 | 5109 | 29798472 |
| Multiple organ dysfunction syndrome | 17.35 | 10.19 | 217 | 148680 | 63270 | 29740311 |
| Tachycardia | 17.30 | 10.19 | 260 | 148637 | 73479 | 29730102 |
| Post procedural infection | 17.23 | 10.19 | 56 | 148841 | 4516 | 29799065 |
| Infection | 17.18 | 10.19 | 509 | 148388 | 77565 | 29726016 |
| Toxic optic neuropathy | 17.14 | 10.19 | 19 | 148878 | 663 | 29802918 |
| Speech disorder developmental | 17.13 | 10.19 | 25 | 148872 | 1154 | 29802427 |
| Hyperbilirubinaemia neonatal | 16.96 | 10.19 | 19 | 148878 | 671 | 29802910 |
| Venoocclusive liver disease | 16.67 | 10.19 | 6 | 148891 | 6607 | 29796974 |
| Incorrect route of product administration | 16.63 | 10.19 | 19 | 148878 | 11296 | 29792285 |
| Prostate cancer | 16.48 | 10.19 | 187 | 148710 | 23770 | 29779811 |
| Congenital bladder anomaly | 16.41 | 10.19 | 13 | 148884 | 293 | 29803288 |
| Influenza | 16.37 | 10.19 | 305 | 148592 | 43093 | 29760488 |
| Rash maculo-papular | 16.24 | 10.19 | 68 | 148829 | 25350 | 29778231 |
| Microphthalmos | 16.19 | 10.19 | 11 | 148886 | 194 | 29803387 |
| Poor venous access | 15.99 | 10.19 | 37 | 148860 | 2443 | 29801138 |
| Umbilical hernia | 15.79 | 10.19 | 47 | 148850 | 3614 | 29799967 |
| Joint effusion | 15.78 | 10.19 | 47 | 148850 | 3616 | 29799965 |
| Haematocrit decreased | 15.76 | 10.19 | 227 | 148670 | 30472 | 29773109 |
| Off label use | 15.71 | 10.19 | 1048 | 147849 | 248242 | 29555339 |
| Immunodeficiency | 15.65 | 10.19 | 52 | 148845 | 4242 | 29799339 |
| Altered state of consciousness | 15.56 | 10.19 | 49 | 148848 | 19870 | 29783711 |
| Injection site bruising | 15.54 | 10.19 | 75 | 148822 | 7263 | 29796318 |
| Fatigue | 15.47 | 10.19 | 1820 | 147077 | 318853 | 29484728 |
| Weight decrease neonatal | 15.31 | 10.19 | 13 | 148884 | 324 | 29803257 |
| Accessory spleen | 15.24 | 10.19 | 10 | 148887 | 166 | 29803415 |
| Otitis media | 15.11 | 10.19 | 37 | 148860 | 2534 | 29801047 |
| Agranulocytosis | 15.09 | 10.19 | 57 | 148840 | 21885 | 29781696 |
| Patent ductus arteriosus | 14.94 | 10.19 | 42 | 148855 | 3127 | 29800454 |
| Ankyloglossia congenital | 14.87 | 10.19 | 12 | 148885 | 278 | 29803303 |
| Arthrodesis | 14.64 | 10.19 | 14 | 148883 | 409 | 29803172 |
| Blood pressure diastolic increased | 14.45 | 10.19 | 38 | 148859 | 2720 | 29800861 |
| Hypermobility syndrome | 14.39 | 10.19 | 11 | 148886 | 235 | 29803346 |
| Full blood count decreased | 14.33 | 10.19 | 130 | 148767 | 15587 | 29787994 |
| Foetal disorder | 14.29 | 10.19 | 17 | 148880 | 641 | 29802940 |
| Cytokine release syndrome | 14.26 | 10.19 | 17 | 148880 | 9916 | 29793665 |
| Hypotension | 14.21 | 10.19 | 834 | 148063 | 199731 | 29603850 |
| Multiple congenital abnormalities | 14.18 | 10.19 | 15 | 148882 | 496 | 29803085 |
| Blood pressure diastolic decreased | 14.16 | 10.19 | 65 | 148832 | 6166 | 29797415 |
| Disease progression | 14.15 | 10.19 | 296 | 148601 | 79578 | 29724003 |
| Product quality issue | 14.09 | 10.19 | 47 | 148850 | 18727 | 29784854 |
| Peripheral artery thrombosis | 14.07 | 10.19 | 33 | 148864 | 2199 | 29801382 |
| Intellectual disability | 14 | 10.19 | 19 | 148878 | 819 | 29802762 |
| Pancreatic calcification | 13.94 | 10.19 | 10 | 148887 | 193 | 29803388 |
| Drug withdrawal syndrome neonatal | 13.93 | 10.19 | 41 | 148856 | 3134 | 29800447 |
| Renal aplasia | 13.88 | 10.19 | 17 | 148880 | 661 | 29802920 |
| Developmental delay | 13.87 | 10.19 | 32 | 148865 | 2109 | 29801472 |
| Sinusitis | 13.87 | 10.19 | 238 | 148659 | 33107 | 29770474 |
| Cerebral haemorrhage | 13.86 | 10.19 | 101 | 148796 | 32786 | 29770795 |
| Akathisia | 13.83 | 10.19 | 6 | 148891 | 5898 | 29797683 |
| Urinary tract infection | 13.79 | 10.19 | 471 | 148426 | 73188 | 29730393 |
| Hypertriglyceridaemia | 13.73 | 10.19 | 12 | 148885 | 8086 | 29795495 |
| Tremor neonatal | 13.73 | 10.19 | 13 | 148884 | 375 | 29803206 |
| Tonsil cancer | 13.73 | 10.19 | 18 | 148879 | 750 | 29802831 |
| Septic arthritis staphylococcal | 13.73 | 10.19 | 14 | 148883 | 443 | 29803138 |
| Blood iron increased | 13.72 | 10.19 | 19 | 148878 | 835 | 29802746 |
| Osteonecrosis of jaw | 13.71 | 10.19 | 47 | 148850 | 18571 | 29785010 |
| Sedation | 13.71 | 10.19 | 39 | 148858 | 16334 | 29787247 |
| Wound | 13.65 | 10.19 | 107 | 148790 | 12295 | 29791286 |
| Upper respiratory tract infection | 13.65 | 10.19 | 202 | 148695 | 27274 | 29776307 |
| Restlessness | 13.50 | 10.19 | 62 | 148835 | 22537 | 29781044 |
| Anal fistula | 13.41 | 10.19 | 47 | 148850 | 3939 | 29799642 |
| Pleural fibrosis | 13.38 | 10.19 | 25 | 148872 | 1419 | 29802162 |
| Injection site swelling | 13.36 | 10.19 | 82 | 148815 | 8698 | 29794883 |
| Joint range of motion decreased | 13.30 | 10.19 | 61 | 148836 | 5784 | 29797797 |
| Hepatic failure | 13.19 | 10.19 | 107 | 148790 | 33936 | 29769645 |
| Neonatal seizure | 13.16 | 10.19 | 14 | 148883 | 466 | 29803115 |
| Finger deformity | 12.94 | 10.19 | 20 | 148877 | 972 | 29802609 |
| Arthritis infective | 12.93 | 10.19 | 36 | 148861 | 2666 | 29800915 |
| Foot deformity | 12.86 | 10.19 | 42 | 148855 | 3395 | 29800186 |
| Crohn's disease | 12.70 | 10.19 | 49 | 148848 | 4303 | 29799278 |
| Foetal heart rate deceleration abnormality | 12.66 | 10.19 | 13 | 148884 | 415 | 29803166 |
| Knee deformity | 12.65 | 10.19 | 12 | 148885 | 347 | 29803234 |
| Hydrocele | 12.64 | 10.19 | 30 | 148867 | 2014 | 29801567 |
| Vascular insufficiency | 12.60 | 10.19 | 12 | 148885 | 349 | 29803232 |
| Emphysema | 12.58 | 10.19 | 85 | 148812 | 9317 | 29794264 |
| Pyelocaliectasis | 12.56 | 10.19 | 20 | 148877 | 997 | 29802584 |
| Skin lesion | 12.56 | 10.19 | 144 | 148753 | 18350 | 29785231 |
| Disseminated intravascular coagulation | 12.55 | 10.19 | 62 | 148835 | 22109 | 29781472 |
| Grip strength decreased | 12.53 | 10.19 | 31 | 148866 | 2137 | 29801444 |
| Hernia pain | 12.53 | 10.19 | 10 | 148887 | 228 | 29803353 |
| Maternal exposure timing unspecified | 12.51 | 10.19 | 12 | 148885 | 352 | 29803229 |
| Moaning | 12.43 | 10.19 | 17 | 148880 | 738 | 29802843 |
| Latent tuberculosis | 12.40 | 10.19 | 19 | 148878 | 916 | 29802665 |
| Injection site erythema | 12.40 | 10.19 | 114 | 148783 | 13720 | 29789861 |
| Congenital anomaly | 12.39 | 10.19 | 23 | 148874 | 1299 | 29802282 |
| Progressive multifocal leukoencephalopathy | 12.33 | 10.19 | 16 | 148881 | 8997 | 29794584 |
| Heart rate decreased | 12.32 | 10.19 | 159 | 148738 | 20835 | 29782746 |
| Urticaria | 12.30 | 10.19 | 194 | 148703 | 54412 | 29749169 |
| Maternal exposure before pregnancy | 12.29 | 10.19 | 12 | 148885 | 360 | 29803221 |
| Malignant neoplasm progression | 12.19 | 10.19 | 270 | 148627 | 72017 | 29731564 |
| Injection site rash | 12.14 | 10.19 | 42 | 148855 | 3497 | 29800084 |
| Kidney infection | 12.12 | 10.19 | 50 | 148847 | 4528 | 29799053 |
| Nerve compression | 12.11 | 10.19 | 36 | 148861 | 2766 | 29800815 |
| Blood insulin increased | 12.08 | 10.19 | 12 | 148885 | 368 | 29803213 |
| Diverticular perforation | 12.05 | 10.19 | 39 | 148858 | 3138 | 29800443 |
| Palmar-plantar erythrodysaesthesia syndrome | 12.02 | 10.19 | 36 | 148861 | 14834 | 29788747 |
| Neutrophil count decreased | 12.01 | 10.19 | 144 | 148753 | 42310 | 29761271 |
| Mouth ulceration | 11.94 | 10.19 | 92 | 148805 | 10517 | 29793064 |
| Blood albumin decreased | 11.91 | 10.19 | 105 | 148792 | 12487 | 29791094 |
| Hepatic enzyme increased | 11.81 | 10.19 | 233 | 148664 | 33261 | 29770320 |
| Malignant melanoma | 11.78 | 10.19 | 70 | 148827 | 7341 | 29796240 |
| Vitamin B12 deficiency | 11.77 | 10.19 | 34 | 148863 | 2571 | 29801010 |
| Ventricular tachycardia | 11.71 | 10.19 | 70 | 148827 | 23792 | 29779789 |
| Anti-erythropoietin antibody positive | 11.64 | 10.19 | 18 | 148879 | 875 | 29802706 |
| Palindromic rheumatism | 11.62 | 10.19 | 9 | 148888 | 196 | 29803385 |
| Joint stiffness | 11.57 | 10.19 | 83 | 148814 | 9278 | 29794303 |
| Spinal disorder | 11.46 | 10.19 | 40 | 148857 | 3345 | 29800236 |
| Plagiocephaly | 11.46 | 10.19 | 11 | 148886 | 323 | 29803258 |
| Hypocalcaemia | 11.41 | 10.19 | 61 | 148836 | 21315 | 29782266 |
| Excessive cerumen production | 11.36 | 10.19 | 10 | 148887 | 262 | 29803319 |
| Folate deficiency | 11.32 | 10.19 | 19 | 148878 | 990 | 29802591 |
| Fistula | 11.32 | 10.19 | 53 | 148844 | 5069 | 29798512 |
| Gangrene neonatal | 11.28 | 10.19 | 9 | 148888 | 205 | 29803376 |
| Frequent bowel movements | 11.25 | 10.19 | 76 | 148821 | 8329 | 29795252 |
| Aspergillus infection | 11.24 | 10.19 | 21 | 148876 | 10193 | 29793388 |
| Contraindicated product administered | 11.18 | 10.19 | 133 | 148764 | 17098 | 29786483 |
| Non-Hodgkin's lymphoma | 11.16 | 10.19 | 26 | 148871 | 1725 | 29801856 |
| Pouchitis | 11.13 | 10.19 | 15 | 148882 | 642 | 29802939 |
| Hypoxia | 11.12 | 10.19 | 169 | 148728 | 47685 | 29755896 |
| Autism spectrum disorder | 11.12 | 10.19 | 22 | 148875 | 1303 | 29802278 |
| Medication error | 11.11 | 10.19 | 60 | 148837 | 20912 | 29782669 |
| Erythema multiforme | 11.11 | 10.19 | 14 | 148883 | 7971 | 29795610 |
| Nephrolithiasis | 11.02 | 10.19 | 179 | 148718 | 24631 | 29778950 |
| Cystitis haemorrhagic | 11.00 | 10.19 | 5 | 148892 | 4782 | 29798799 |
| Mean cell volume increased | 10.98 | 10.19 | 29 | 148868 | 2081 | 29801500 |
| Hepatitis fulminant | 10.96 | 10.19 | 3 | 148894 | 3938 | 29799643 |
| Dairy intolerance | 10.86 | 10.19 | 3 | 148894 | 3 | 29803578 |
| Metastases to thyroid | 10.86 | 10.19 | 3 | 148894 | 3 | 29803578 |
| Hypermethioninaemia | 10.86 | 10.19 | 3 | 148894 | 3 | 29803578 |
| Allergy to arthropod bite | 10.86 | 10.19 | 3 | 148894 | 3 | 29803578 |
| Congenital diaphragmatic hernia | 10.85 | 10.19 | 9 | 148888 | 217 | 29803364 |
| Acute graft versus host disease | 10.81 | 10.19 | 8 | 148889 | 5856 | 29797725 |
| Lactic acidosis | 10.81 | 10.19 | 101 | 148796 | 31112 | 29772469 |
| Acute hepatic failure | 10.79 | 10.19 | 27 | 148870 | 11800 | 29791781 |
| Subdural haematoma | 10.77 | 10.19 | 53 | 148844 | 18919 | 29784662 |
| Pulmonary artery stenosis congenital | 10.73 | 10.19 | 13 | 148884 | 500 | 29803081 |
| Unresponsive to stimuli | 10.72 | 10.19 | 82 | 148815 | 26337 | 29777244 |
| Blood lactic acid increased | 10.69 | 10.19 | 8 | 148889 | 5822 | 29797759 |
| C-reactive protein decreased | 10.68 | 10.19 | 24 | 148873 | 1554 | 29802027 |
| Interstitial lung disease | 10.68 | 10.19 | 223 | 148674 | 59974 | 29743607 |
| Gastrointestinal infection | 10.67 | 10.19 | 42 | 148855 | 3723 | 29799858 |
| Oedema | 10.63 | 10.19 | 150 | 148747 | 42843 | 29760738 |
| Stevens-Johnson syndrome | 10.58 | 10.19 | 48 | 148849 | 17508 | 29786073 |
| Pyrexia | 10.49 | 10.19 | 1293 | 147604 | 293196 | 29510385 |
| Cleft palate | 10.49 | 10.19 | 14 | 148883 | 594 | 29802987 |
| Blood pressure diastolic abnormal | 10.36 | 10.19 | 21 | 148876 | 1266 | 29802315 |
| Lung neoplasm malignant | 10.36 | 10.19 | 118 | 148779 | 15014 | 29788567 |
| Oesophageal adenocarcinoma | 10.35 | 10.19 | 17 | 148880 | 870 | 29802711 |
| Foetal hypokinesia | 10.34 | 10.19 | 11 | 148886 | 366 | 29803215 |
| Steatorrhoea | 10.30 | 10.19 | 15 | 148882 | 691 | 29802890 |
| Decreased vibratory sense | 10.27 | 10.19 | 11 | 148886 | 369 | 29803212 |
| Toxic epidermal necrolysis | 10.25 | 10.19 | 50 | 148847 | 17890 | 29785691 |
| Foetal distress syndrome | 10.25 | 10.19 | 18 | 148879 | 973 | 29802608 |
| Anaemia vitamin B12 deficiency | 10.24 | 10.19 | 10 | 148887 | 300 | 29803281 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A11HA02 | ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations |
| ATC | J04AM08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
| FDA Chemical/Ingredient | N0000005657 | Vitamin B 6 |
| FDA Chemical/Ingredient | N0000175452 | Analogs/Derivatives |
| CHEBI has role | CHEBI:23357 | cofactor |
| CHEBI has role | CHEBI:75771 | mus musculus metabolite |
| CHEBI has role | CHEBI:75772 | baker's yeast metabolite |
| CHEBI has role | CHEBI:76971 | e.coli metabolites |
| CHEBI has role | CHEBI:77746 | h. sapiens metabolites |
| MeSH PA | D018977 | Micronutrients |
| MeSH PA | D014803 | Vitamin B Complex |
| MeSH PA | D014815 | Vitamins |
| FDA EPC | N0000192800 | Vitamin B6 Analog |
| CHEBI has role | CHEBI:75769 | vitamin b |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pregnancy, function | indication | 289908002 | |
| Vitamin B6 deficiency | indication | 386080007 | DOID:8455 |
| Breastfeeding (mother) | indication | 413712001 | |
| Drug-Induced Pyridoxine Deficiency | indication | ||
| Pyridoxine-Dependent Seizure | indication | ||
| Nutritional disorder | contraindication | 2492009 | DOID:374 |
| Alcoholism | contraindication | 7200002 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Hyperkalemia | contraindication | 14140009 | |
| Gastroenteritis | contraindication | 25374005 | DOID:2326 |
| Dehydration | contraindication | 34095006 | |
| Depressive disorder | contraindication | 35489007 | |
| Acute hepatitis | contraindication | 37871000 | |
| Hemosiderosis | contraindication | 39011001 | DOID:12119 |
| Hypokalemia | contraindication | 43339004 | |
| Chronic heart failure | contraindication | 48447003 | |
| Gastrectomy | contraindication | 53442002 | |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Schizophrenia | contraindication | 58214004 | DOID:5419 |
| Acute nephropathy | contraindication | 58574008 | |
| Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
| Metabolic acidosis | contraindication | 59455009 | |
| Hepatic failure | contraindication | 59927004 | |
| Hemolytic anemia | contraindication | 61261009 | DOID:583 |
| Diarrhea | contraindication | 62315008 | |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Poisoning by acetaminophen | contraindication | 70273001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
| Autoimmune disease | contraindication | 85828009 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Acute hepatic failure | contraindication | 197270009 | |
| Impaired renal function disorder | contraindication | 197663003 | |
| Gastroparesis | contraindication | 235675006 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Rhabdomyolysis | contraindication | 240131006 | |
| Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
| Diabetic - poor control | contraindication | 268519009 | |
| Peripheral nerve disease | contraindication | 302226006 | |
| Primary adrenocortical insufficiency | contraindication | 373662000 | |
| Diverticular disease | contraindication | 397881000 | |
| Hemochromatosis | contraindication | 399187006 | DOID:2352 |
| Ketoacidosis in diabetes mellitus | contraindication | 420422005 | DOID:1837 |
| Diabetic peripheral neuropathy | contraindication | 424736006 | |
| Slow acetylator due to N-acetyltransferase enzyme variant | contraindication | 425079005 | |
| Chronic Hepatic Disease | contraindication | ||
| Genitourinary Tract Infections | contraindication | ||
| Repeated Blood Transfusions | contraindication | ||
| Prolonged-Severe Nausea and Vomiting | contraindication | ||
| Esophageal Compression | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.98 | acidic |
| pKa2 | 13.8 | acidic |
| pKa3 | 4.94 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Phosphoserine aminotransferase | Enzyme | WOMBAT-PK | |||||||
| Cystathionine beta-synthase | Enzyme | WOMBAT-PK | |||||||
| Pyridoxal kinase | Kinase | WOMBAT-PK | |||||||
| Pyridoxal phosphate phosphatase | Enzyme | WOMBAT-PK | |||||||
| Pyridoxine-5'-phosphate oxidase | Enzyme | WOMBAT-PK | |||||||
| Serine hydroxymethyltransferase, cytosolic | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4019922 | VUID |
| N0000148007 | NUI |
| D02179 | KEGG_DRUG |
| 58-56-0 | SECONDARY_CAS_RN |
| 4017489 | VANDF |
| 4017779 | VANDF |
| 4018569 | VANDF |
| 4019922 | VANDF |
| 4021899 | VANDF |
| C0034272 | UMLSCUI |
| CHEBI:16709 | CHEBI |
| UEG | PDB_CHEM_ID |
| 1054 | PUBCHEM_CID |
| CHEMBL1364 | ChEMBL_ID |
| CHEMBL1200756 | ChEMBL_ID |
| D011736 | MESH_DESCRIPTOR_UI |
| DB00165 | DRUGBANK_ID |
| 2216 | INN_ID |
| KV2JZ1BI6Z | UNII |
| 203164 | RXNORM |
| 35074 | MMSL |
| 4979 | MMSL |
| 4994 | MMSL |
| 5393 | MMSL |
| 5686 | MMSL |
| 6601 | MMSL |
| d00412 | MMSL |
| 001058 | NDDF |
| 004538 | NDDF |
| 126227009 | SNOMEDCT_US |
| 430469009 | SNOMEDCT_US |
| 767286000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| NataFort | HUMAN PRESCRIPTION DRUG LABEL | 10 | 0178-0716 | TABLET | 10 mg | ORAL | Unapproved drug other | 12 sections |
| CitraNatal Harmony 3.0 | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0796 | CAPSULE, GELATIN COATED | 25 mg | ORAL | unapproved drug other | 10 sections |
| CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0798 | CAPSULE, GELATIN COATED | 25 mg | ORAL | UNULLPPROVED DRUG OTHER | 11 sections |
| CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0799 | CAPSULE, GELATIN COATED | 25 mg | ORAL | Unapproved drug other | 11 sections |
| CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0812 | CAPSULE, GELATIN COATED | 25 mg | ORAL | Unapproved drug other | 11 sections |
| CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 20 mg | ORAL | unapproved drug other | 11 sections |
| CitraNatal 90 DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0829 | TABLET | 20 mg | ORAL | Unapproved drug other | 11 sections |
| CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0178-0858 | TABLET | 20 mg | ORAL | Unapproved drug other | 12 sections |
| CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 14 | 0178-0859 | TABLET | 20 mg | ORAL | Unapproved drug other | 9 sections |
| CitraNatal Medley | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0896 | CAPSULE, GELATIN COATED | 12.50 mg | ORAL | unapproved drug other | 10 sections |
| CitraNatal DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0898 | TABLET | 20 mg | ORAL | Unapproved drug other | 11 sections |
| Doxylamine Succinate and Pyridoxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-4615 | TABLET, DELAYED RELEASE | 10 mg | ORAL | ANDA | 26 sections |
| Doxylamine succinate and pyridoxine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-2132 | TABLET, DELAYED RELEASE | 10 mg | ORAL | ANDA | 25 sections |
| VitafolOne | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-0070 | CAPSULE, GELATIN COATED | 2.50 mg | ORAL | unapproved drug other | 7 sections |
| Vitafol Caplet | HUMAN PRESCRIPTION DRUG LABEL | 12 | 0642-0072 | CAPSULE | 15 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
| Select OB | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0077 | TABLET, CHEWABLE | 2.50 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
| Vitafol OB Caplet | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0079 | TABLET | 2.50 mg | ORAL | Unapproved drug other | 14 sections |
| Vitafol Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0092 | CAPSULE, LIQUID FILLED | 2.50 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
| Vitafol Ultra | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0093 | CAPSULE, LIQUID FILLED | 2.50 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
| Vitafol Nano | HUMAN PRESCRIPTION DRUG LABEL | 7 | 0642-0094 | TABLET, COATED | 2.50 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
| Select OB | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0120 | TABLET, CHEWABLE | 2.50 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
| Strovite Forte Caplet | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0642-0204 | TABLET, COATED | 25 mg | ORAL | UNULLPPROVED DRUG OTHER | 15 sections |
| Strovite One Caplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 25 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
| Reaphirm Plant Source DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-3010 | CAPSULE, GELATIN COATED | 2.50 mg | ORAL | unapproved drug other | 7 sections |
| Vitafol | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0642-7468 | STRIP | 2.50 mg | ORAL | Unapproved drug other | 13 sections |
| Vitafol Fe Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-7473 | CAPSULE, LIQUID FILLED | 2.50 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
| Marnatal F | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0682-1570 | CAPSULE | 5 mg | ORAL | UNULLPPROVED DRUG OTHER | 4 sections |
| BACMIN | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0682-3001 | TABLET, COATED | 25 mg | ORAL | UNULLPPROVED DRUG OTHER | 10 sections |
| O-Cal Prenatal Vitamin | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0813-0202 | TABLET | 12 mg | ORAL | UNULLPPROVED DRUG OTHER | 6 sections |
| Dialyvite Supreme D | HUMAN PRESCRIPTION DRUG LABEL | 13 | 10542-009 | TABLET, COATED | 25 mg | ORAL | Unapproved drug other | 7 sections |