candicidin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, polyene derivatives 4424 1403-17-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • candicidin
  • Candicidin D
Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.
  • Molecular weight: 1109.32
  • Formula: C59H84N2O18
  • CLOGP: -1.46
  • LIPINSKI: 3
  • HAC: 20
  • HDO: 11
  • TPSA: 356.38
  • ALOGS: -5.07
  • ROTB: 10
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
6 mg V

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 22
kinase-selectivity-class AXL,GRK2,MAP2K6 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G01AA04 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
CHEBI has role CHEBI:76969 bacterial metabolite
CHEBI has role CHEBI:86327 antifungal drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000935 Antifungal Agents

Related Drugs by ATC class:

G01AA Antibiotics 10 drugs
amphotericin Bcarfecillinchloramphenicolclindamycinhachimycinmepartricinnatamycinnystatinoxytetracyclinepentamycin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Candidiasis of vagina indication 72934000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.46 acidic
pKa2 10.11 acidic
pKa3 11.12 acidic
pKa4 12.11 acidic
pKa5 12.74 acidic
pKa6 13.88 acidic
pKa7 8.62 Basic
pKa8 2.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03347 KEGG_DRUG
137397-23-0 SECONDARY_CAS_RN
C0006834 UMLSCUI
CHEBI:354984 CHEBI
CHEMBL6067990 ChEMBL_ID
DB01152 DRUGBANK_ID
2013 INN_ID
48N2IYJ202 UNII
10079874 PUBCHEM_CID
002890 NDDF
81816007 SNOMEDCT_US
D002174 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None