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| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, protein-synthesis inhibitors, tetracycline derivatives | 2041 | 79-57-2 |
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
| 1 | g | P |
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 72.32 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 58 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.70 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.90 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 10 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 0.20 mg/mL | Bocci G, Oprea TI, Benet LZ |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -0.686 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.542 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 0.847 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 2.089 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 52.530 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 39.890 | % | High | 1 |
| herg | hERG pIC50 | 4.712 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 2.023 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.289 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 52.590 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MTOR,NTRK2,PDK1,PDK2,PIK3CA,PIK3CB,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK | 64 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,JAK2,MAP2K6,MAP3K14,MAP3K2,MAPK12,MAPK7,MAPK8,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 | 21 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 1.012 | High | 1 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 3.811 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 5.957 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 47.300 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 4.036 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | Moderate | 0.68 | |
| pppb | Pig plasma protein binding (% unbound) | 48.960 | % | High | 1 |
| rat-kpuu-brain | Rat brain Kpuu | 0.009 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 1.318 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 82.590 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 40.500 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 909.913 | uM | High | 1 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 8, 1964 | FDA | PFIZER |
None
None
None
None
| Source | Code | Description |
|---|---|---|
| ATC | A01AB25 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment |
| ATC | D06AA03 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Tetracycline and derivatives |
| ATC | G01AA07 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Antibiotics |
| ATC | J01AA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines |
| ATC | J01AA56 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines |
| ATC | S01AA04 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
| FDA CS | M0021223 | Tetracyclines |
| FDA EPC | N0000175505 | Tetracycline-class Antimicrobial |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drug |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:48001 | protein synthesis inhibitor |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:76969 | bacterial metabolite |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Trachoma | indication | 2576002 | DOID:11265 |
| Actinomycotic infection | indication | 11817007 | DOID:8478 |
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Gingivostomatitis | indication | 20607006 | |
| Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
| Granuloma inguinale | indication | 28867007 | DOID:9113 |
| Acute gonococcal urethritis | indication | 29864006 | |
| Acute gonococcal epididymo-orchitis | indication | 30168008 | DOID:10802 |
| Bronchitis | indication | 32398004 | DOID:6132 |
| Sinusitis | indication | 36971009 | |
| Gonorrhea of rectum | indication | 42746002 | |
| Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
| Urinary tract infectious disease | indication | 68566005 | |
| Yaws | indication | 70647001 | DOID:10371 |
| Gonorrhea of pharynx | indication | 74372003 | |
| Rickettsialpox | indication | 75096007 | DOID:11103 |
| Ornithosis | indication | 75116005 | DOID:11262 |
| Brucellosis | indication | 75702008 | DOID:11077 |
| Syphilis | indication | 76272004 | |
| Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
| Rocky Mountain spotted fever | indication | 186772009 | |
| Q fever | indication | 186788009 | DOID:11100 |
| Lymphogranuloma venereum | indication | 186946009 | DOID:13819 |
| Pneumonia | indication | 233604007 | DOID:552 |
| Inclusion conjunctivitis | indication | 266109000 | |
| Infective otitis media | indication | 312218008 | |
| Bacterial keratitis | indication | 314557000 | |
| Pharyngitis | indication | 405737000 | DOID:2275 |
| Anthrax | indication | 409498004 | DOID:7427 |
| Relapsing fever | indication | 420079008 | DOID:13034 |
| Chlamydia trachomatis infection of genital structure | indication | 428015005 | |
| Rectal Chlamydia Trachomatis Infection | indication | ||
| Typhus Infections | indication | ||
| Superficial Ocular Infection | indication | ||
| Tularemia | off-label use | 19265001 | |
| Enterocolitis | off-label use | 43752006 | |
| Pneumonia due to Mycoplasma pneumoniae | off-label use | 46970008 | |
| Plague | off-label use | 58750007 | DOID:3482 |
| Cholangitis | off-label use | 82403002 | DOID:9446 |
| Chlamydial infection | off-label use | 105629000 | |
| Infectious disease of abdomen | off-label use | 128070006 | |
| Ocular rosacea | off-label use | 200933006 | |
| Complete atrioventricular block | contraindication | 27885002 | |
| Shock | contraindication | 27942005 | |
| Hypovolemia | contraindication | 28560003 | |
| Glomerulonephritis | contraindication | 36171008 | DOID:2921 |
| Acute hepatitis | contraindication | 37871000 | |
| Hypokalemia | contraindication | 43339004 | |
| Uremia | contraindication | 44730006 | DOID:4676 |
| Stokes-Adams syndrome | contraindication | 46935006 | |
| Chronic heart failure | contraindication | 48447003 | |
| Atrial fibrillation | contraindication | 49436004 | DOID:0060224 |
| Sinus bradycardia | contraindication | 49710005 | |
| Acute nephropathy | contraindication | 58574008 | |
| Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
| Decreased respiratory function | contraindication | 80954004 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Partial atrioventricular block | contraindication | 195039008 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pregnancy, function | contraindication | 289908002 | |
| Hypoxia | contraindication | 389086002 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Reduced Hepatic Blood Flow | contraindication | ||
| Lidocaine Toxicity | contraindication |
| Species | Use | Relation |
|---|---|---|
| Bees | American foulbrood caused by Paenibacillus larvae | Indication |
| Bees | European foulbrood caused by Streptococcus pluton | Indication |
| Cats | Bacterial pneumonia caused by Brucella bronchiseptica | Indication |
| Cats | Tonsillitis caused by Streptococcus hemolyticus | Indication |
| Cats | Bacterial enteritis caused by Escherichia coli | Indication |
| Cats | Urinary tract infections caused by Escherichia coli | Indication |
| Cats | Wound infections caused by Staphylococcus aureus | Indication |
| Cattle | Pneumonia and shipping fever complex associated with Pasteurella species | Indication |
| Cattle | Pneumonia and shipping fever complex associated with Actinobacillus pleuropneumoniae | Indication |
| Cattle | Pneumonia and shipping fever complex associated with Klebsiella species | Indication |
| Cattle | Foot-rot caused by Spherophorus necrophorus | Indication |
| Cattle | Diphtheria caused by Spherophorus necrophorus | Indication |
| Cattle | Bacterial enteritis caused by Salmonella typhimurium | Indication |
| Cattle | Bacterial enteritis caused by Escherichia coli | Indication |
| Cattle | Wooden tongue caused by Actinobacillus lignieresi | Indication |
| Cattle | Leptospirosis caused by Leptospira pomona | Indication |
| Cattle | Wound infections caused by staphylococcal and streptococcal organisms | Indication |
| Cattle | Acute metritis caused by staphylococcal and streptococcal organisms | Indication |
| Cattle | Reduction of the incidence of liver abscesses | Indication |
| Cattle | Anaplasmosis caused by Anaplasma marginale | Indication |
| Cattle | Anthrax caused by Bacillus anthracis | Indication |
| Cattle | Bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis | Indication |
| Chickens | Air sacculitis (air-sac disease chronic respiratory disease) caused by Mycoplasma gallisepticum | Indication |
| Chickens | Air sacculitis (air-sac disease chronic respiratory disease) caused by Escherichia coli | Indication |
| Chickens | Cholera caused by Pasteurella multocida | Indication |
| Chickens | Infectious sinusitis caused by Mycoplasma gallisepticum | Indication |
| Chickens | Infectious synovitis caused by Mycoplasma synoviae | Indication |
| Dogs | Bacterial pneumonia caused by Brucella bronchiseptica | Indication |
| Dogs | Tonsillitis caused by Streptococcus hemolyticus | Indication |
| Dogs | Bacterial enteritis caused by Escherichia coli | Indication |
| Dogs | Urinary tract infections caused by Staphylococcus species | Indication |
| Dogs | Urinary tract infections caused by Escherichia coli | Indication |
| Dogs | Wound infections caused by Staphylococcus aureus | Indication |
| Fish - Catfish | Bacterial hemorrhagic septicemia caused by Aeromonas hydrophila | Indication |
| Fish - Catfish | Pseudomonas disease | Indication |
| Fish - Finfish | Skeletal marking of finfish fry and fingerlings | Indication |
| Fish - Freshwater-reared Oncorhynchus mykiss | Columnaris disease associated with Flavobacterium columnare | Indication |
| Fish - Freshwater-reared Salmonids | Coldwater disease associated with Flavobacterium psychrophilum | Indication |
| Fish - Pacific Salmon | Marking of skeletal tissue | Indication |
| Fish - Salmonids | Ulcer disease caused by Haemophilus piscium | Indication |
| Fish - Salmonids | Furunculosis caused by Aeromonas salmonicida | Indication |
| Fish - Salmonids | Bacterial hemorrhagic septicemia caused by Aeromonas hydrophila | Indication |
| Fish - Salmonids | Pseudomonas disease | Indication |
| Horses | No Use Class Stated Or Implied | Indication |
| Lobsters | Gaffkemia caused by Aerococcus viridans | Indication |
| Sheep | Bacterial enteritis caused by Escherichia coli | Indication |
| Sheep | Bacterial pneumonia caused by Pasteurella multocida | Indication |
| Swine | Leptospirosis caused by Leptospira pomona | Indication |
| Swine | Bacterial enteritis caused by Escherichia coli | Indication |
| Swine | Bacterial enteritis caused by Escherichia coli | Indication |
| Swine | Bacterial pneumonia caused by Pasteurella multocida | Indication |
| Swine | Bacterial enteritis caused by Salmonella choleraesuis | Indication |
| Turkeys | Complicating bacterial organisms associated with bluecomb | Indication |
| Turkeys | Hexamitiasis caused by Hexamita meleagridis | Indication |
| Turkeys | Iinfectious synovitis caused by Mycoplasma synoviae | Indication |
| Turkeys | Air sacculitis (air-sac disease chronic respiratory disease) caused by Mycoplasma gallisepticum | Indication |
| Turkeys | Cholera caused by Pasteurella multocida | Indication |
| Turkeys | Infectious sinusitis caused by Mycoplasma gallisepticum | Indication |
| Turkeys | Air sacculitis (air-sac disease chronic respiratory disease) caused by Escherichia coli | Indication |
| Product | Applicant | Ingredients |
|---|---|---|
| Terramycin Vet Capsules | Zoetis Inc. | 1 |
| TERRAMYCIN-343, TERRAMYCIN, TERRAMYCIN Soluble Powder Concentrate | Zoetis Inc. | 1 |
| Terramycin Ophthalmic Ointment with Polymyxin | Zoetis Inc. | 2 |
| Liquamycin Injectable, Terramycin Injectable | Zoetis Inc. | 1 |
| TM-50 , TM-50 D , TM-100 , TM-100D | Phibro Animal Health Corp. | 1 |
| Terramycin Scours Tablets | Zoetis Inc. | 1 |
| Liquamycin Intramuscular | Zoetis Inc. | 2 |
| Liqua-Cortril Spray, Terra-Cortril Spray | Zoetis Inc. | 2 |
| MAGNA-TERRAMYCIN Soluble Powder | Zoetis Inc. | 2 |
| OXY WS | Phibro Animal Health Corp. | 1 |
| Terramycin 100 for Fish, Terramycin 200 for Fish | Phibro Animal Health Corp. | 1 |
| Oxyject | Cronus Pharma Specialities India Private Limited | 1 |
| MGA (liquid) and TM | Zoetis Inc. | 2 |
| MGA and TM | Zoetis Inc. | 2 |
| Bio-Mycin, Oxy-Tet 50 | Cronus Pharma Specialities India Private Limited | 1 |
| Oxytetracycline-50 | Huvepharma EOOD | 1 |
| Aquachel 100 mg | Zoetis Inc. | 2 |
| Rachelle Oxyvet Injection | Zoetis Inc. | 1 |
| Liquamycin 100, Terramycin 100 | Zoetis Inc. | 1 |
| Neo-Terramycin 100/100, Neo-Terramycin 100/100D, Neo-Terramycin 50/50, Neo-Terramycin 50/50D | Phibro Animal Health Corp. | 2 |
| Terramycin 10, Terramycin 30, Terramycin 50, Terramycin 100, Terramycin 200, Terramycin 200 Granular, Terramycin 100MR | Phibro Animal Health Corp. | 1 |
| Bio-Mycin C, Oxy-Tet Injection | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Oxyject 100 | Cronus Pharma Specialities India Private Limited | 1 |
| Coban/TM | Phibro Animal Health Corp. | 2 |
| Aquachel-100, Oxyvet-100 | Zoetis Inc. | 1 |
| TM plus Robenz | Phibro Animal Health Corp. | 2 |
| Medamycin Injectable | Cronus Pharma Specialities India Private Limited | 1 |
| Liquamycin LA-200, Liquamycin LA-200 (Rx) | Zoetis Inc. | 1 |
| Compudose 200, Encore (Compudose 400 ) | Elanco US Inc. | 2 |
| OXYMarine, Oxytet Soluble | Huvepharma EOOD | 1 |
| Pennox 50, Pennox 100-MR, Pennox 100 Hi-Flo, Pennox 200 Hi-Flo | Pharmgate Inc. | 1 |
| Neo-Oxy 100/100 MR, Neo-Oxy 50/50 | Pharmgate Inc. | 2 |
| TM plus Bio-Cox | Phibro Animal Health Corp. | 2 |
| BOVATEC and TM | Zoetis Inc. | 2 |
| Oxytetracycline Hydrochloride Injection | Bimeda Animal Health Limited | 1 |
| OXY 1000 Calf Bolus, OXY 500 Calf Bolus | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Noromycin 300 LA, TETRADURE 300 | Norbrook Laboratories, Ltd. | 1 |
| Mecadox and Terramycin | Phibro Animal Health Corp. | 2 |
| Hexasol Injection | Norbrook Laboratories, Ltd. | 2 |
| Bio-Mycin 200 , Oxy-Tet 200 Injectable Solution | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Pennox 343 | Pharmgate Inc. | 1 |
| AGRIMYCIN-343 | Huvepharma EOOD | 1 |
| Oxytetracycline Hydrochloride Injection | Huvepharma EOOD | 1 |
| Sacox / Terramycin | Huvepharma EOOD | 2 |
| Oxytetracycline Injection, Oxytetracycline Injection | Bimeda Animal Health Limited | 1 |
| Maxim-200 Injection, Oxytetracycline Hydrochloride Injection 200mg | Huvepharma EOOD | 1 |
| Agrimycin - 200 | Huvepharma EOOD | 1 |
| Tetroxy HCA-280, Tetroxy HCA-1772, Tetroxy HCA-1400 | Bimeda Animal Health Limited | 1 |
| Tetroxy 25 | Bimeda Animal Health Limited | 1 |
| Oxytetracycline 200, Pennox 200 | Pharmgate Inc. | 1 |
| Tetroxy 343 | Bimeda Animal Health Limited | 1 |
| Oxytetracycline Injection 200 | Norbrook Laboratories, Ltd. | 1 |
| Oxytet 100 | Norbrook Laboratories, Ltd. | 1 |
| Tetroxy Aquatic | Bimeda Animal Health Limited | 1 |
| Tetroxy-LA | Bimeda Animal Health Limited | 1 |
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.29 | acidic |
| pKa2 | 7.19 | acidic |
| pKa3 | 9.79 | acidic |
| pKa4 | 11.29 | acidic |
| pKa5 | 12.0 | acidic |
| pKa6 | 12.56 | acidic |
| pKa7 | 13.24 | acidic |
| pKa8 | 9.06 | Basic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 30S ribosomal protein S4 | Ribosomal protein | WOMBAT-PK | |||||||
| 30S ribosomal protein S9 | Ribosomal protein | WOMBAT-PK |
| ID | Source |
|---|---|
| 4018624 | VUID |
| N0000146937 | NUI |
| D00205 | KEGG_DRUG |
| 6153-64-6 | SECONDARY_CAS_RN |
| 4018623 | VANDF |
| 4018624 | VANDF |
| 4018625 | VANDF |
| C0030092 | UMLSCUI |
| CHEBI:133011 | CHEBI |
| OTC | PDB_CHEM_ID |
| CHEMBL1517 | ChEMBL_ID |
| CHEMBL3989568 | ChEMBL_ID |
| CHEMBL1607480 | ChEMBL_ID |
| D010118 | MESH_DESCRIPTOR_UI |
| DB00595 | DRUGBANK_ID |
| 10919 | IUPHAR_LIGAND_ID |
| 13303-91-8 | SECONDARY_CAS_RN |
| 2058-46-0 | SECONDARY_CAS_RN |
| X20I9EN955 | UNII |
| 54675779 | PUBCHEM_CID |
| 1545999 | RXNORM |
| 2370 | MMSL |
| 33508 | MMSL |
| 5221 | MMSL |
| 5222 | MMSL |
| d01070 | MMSL |
| 002742 | NDDF |
| 002743 | NDDF |
| 002744 | NDDF |
| 1269152006 | SNOMEDCT_US |
| 22969001 | SNOMEDCT_US |
| 372675006 | SNOMEDCT_US |
| 395819008 | SNOMEDCT_US |
| 442345001 | SNOMEDCT_US |
| 54729007 | SNOMEDCT_US |
| 103 | INN_ID |
None