pyrrolnitrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
NO2 - derivatives 3513 1018-71-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyrrolnitrin
  • pyrrolnitrine
3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium.
  • Molecular weight: 257.07
  • Formula: C10H6Cl2N2O2
  • CLOGP: 3.67
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 61.61
  • ALOGS: -3.55
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70 50
kinase-selectivity-class AXL,CDK9,DYRK1B,EIF2AK3,GRK2,GSK3A,GSK3B,MAP2K6,MAPK1,MAPK7,MET,PDK4,SIK2,STK33,TEK,TTK 16
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AA07 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Antibiotics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
CHEBI has role CHEBI:76969 bacterial metabolite
CHEBI has role CHEBI:86327 antifungal drug

Related Drugs by ATC class:

D01AA Antibiotics 6 drugs
griseofulvinhachimycinmepartricinnatamycinnystatinpecilocin

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.93 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01094 KEGG_DRUG
C0034336 UMLSCUI
CHEBI:32079 CHEBI
CHEMBL97972 ChEMBL_ID
DB13603 DRUGBANK_ID
D011764 MESH_DESCRIPTOR_UI
13916 PUBCHEM_CID
2283 INN_ID
N0P24B6EDQ UNII

Pharmaceutical products:

None