clindamycin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 678 18323-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clindamycin hydrochloride hydrate
  • clindamycin
  • 7-Chloro-7-deoxylincomycin
  • 7-Chlorolincomycin
  • 7-Deoxy-7(S)-chlorolincomycin
  • chlolincocin
  • clincin
  • clinimycin
  • Dalacin C
  • dalacine
  • clindamycin hydrochloride
  • clindamycin HCl
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
  • Molecular weight: 424.98
  • Formula: C18H33ClN2O5S
  • CLOGP: 2.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 102.26
  • ALOGS: -2.14
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g V
1.20 g O
1.80 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 13 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 70.59 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 87 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.79 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 22, 1970 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 3294.04 10.67 2050 31922 248960 50322192
Acute generalised exanthematous pustulosis 342.36 10.67 151 33821 8787 50562365
Rash maculo-papular 195.72 10.67 154 33818 26487 50544665
Rash 154.01 10.67 640 33332 436831 50134321
Toxic skin eruption 153.20 10.67 95 33877 11156 50559996
Clostridium difficile infection 149.11 10.67 129 33843 25310 50545842
Type IV hypersensitivity reaction 125.19 10.67 51 33921 2431 50568721
Urticaria 111.03 10.67 259 33713 129302 50441850
Dermatitis allergic 109.85 10.67 81 33891 12639 50558513
Symmetrical drug-related intertriginous and flexural exanthema 95.74 10.67 26 33946 336 50570816
Drug reaction with eosinophilia and systemic symptoms 94.95 10.67 106 33866 28318 50542834
Abortion spontaneous 79.72 10.67 118 33854 41654 50529498
Clostridium difficile colitis 78.69 10.67 77 33895 17665 50553487
Hidradenitis 74.42 10.67 33 33939 1942 50569210
Graft infection 68.69 10.67 17 33955 148 50571004
Drug resistance 65.46 10.67 72 33900 18917 50552235
Loss of employment 64.62 10.67 28 33944 1558 50569594
Pemphigus 59.16 10.67 6 33966 120160 50450992
Synovitis 58.92 10.67 7 33965 123858 50447294
Multiple organ dysfunction syndrome 58.51 10.67 114 33858 50223 50520929
Cellulitis 55.68 10.67 137 33835 70661 50500491
Pseudomembranous colitis 55.15 10.67 30 33942 2755 50568397
Pathogen resistance 53.14 10.67 38 33934 5651 50565501
Glossodynia 51.48 10.67 8 33964 115561 50455591
Pruritus 45.59 10.67 336 33636 283232 50287920
Abscess 45.56 10.67 52 33920 14220 50556932
Systemic lupus erythematosus 45.03 10.67 19 33953 140603 50430549
Eosinophilia 45.01 10.67 59 33913 18593 50552559
Erythema 42.69 10.67 203 33769 146211 50424941
Hand deformity 42.28 10.67 8 33964 100191 50470961
Diarrhoea 41.86 10.67 589 33383 587887 49983265
Necrotising oesophagitis 40.62 10.67 10 33962 85 50571067
Toxic epidermal necrolysis 38.18 10.67 58 33914 20934 50550218
Death 37.45 10.67 104 33868 325275 50245877
Tubo-ovarian abscess 36.20 10.67 12 33960 316 50570836
Rheumatoid arthritis 36.06 10.67 50 33922 202500 50368652
Anaphylactic reaction 34.72 10.67 97 33875 53958 50517194
Type I hypersensitivity 34.66 10.67 21 33951 2364 50568788
Anti-cyclic citrullinated peptide antibody positive 33.53 10.67 4 33968 70583 50500569
Pneumococcal infection 33.52 10.67 12 33960 400 50570752
Osteonecrosis of jaw 33.42 10.67 70 33902 32456 50538696
Joint swelling 33.23 10.67 72 33900 245214 50325938
Alopecia 33.14 10.67 72 33900 244975 50326177
Osteomyelitis 32.78 10.67 56 33916 22297 50548855
Infusion related reaction 32.08 10.67 40 33932 169517 50401635
Upper respiratory tract infection bacterial 31.33 10.67 8 33964 80 50571072
Hepatic steatosis 30.51 10.67 57 33915 24327 50546825
Toxic shock syndrome streptococcal 30.23 10.67 8 33964 93 50571059
Premature delivery 29.21 10.67 55 33917 23608 50547544
Abscess neck 29.02 10.67 12 33960 594 50570558
Staphylococcal infection 28.07 10.67 69 33903 35547 50535605
Gastric disorder 26.27 10.67 60 33912 29488 50541664
Hepatitis infectious mononucleosis 26.18 10.67 7 33965 85 50571067
Arthropathy 26.12 10.67 41 33931 157865 50413287
Fatigue 25.87 10.67 328 33644 707273 49863879
Acute kidney injury 24.85 10.67 248 33724 227810 50343342
Completed suicide 24.02 10.67 32 33940 131857 50439295
Peripheral swelling 23.53 10.67 66 33906 205870 50365282
Helicobacter infection 23.15 10.67 3 33969 49699 50521453
Toxicity to various agents 22.90 10.67 70 33902 212429 50358723
Mastitis 22.67 10.67 16 33956 2331 50568821
Leukocytosis 22.50 10.67 48 33924 22531 50548621
Contraindicated product administered 22.50 10.67 41 33931 148917 50422235
Intentional overdose 22.44 10.67 7 33965 62497 50508655
Hepatic enzyme increased 22.41 10.67 36 33936 137344 50433808
Discomfort 22.17 10.67 24 33948 108356 50462796
Rash morbilliform 22.07 10.67 17 33955 2829 50568323
Type IIb hyperlipidaemia 21.83 10.67 5 33967 30 50571122
Pericarditis 21.62 10.67 13 33959 78676 50492476
Oesophageal ulcer 21.09 10.67 19 33953 3926 50567226
Pyrexia 20.98 10.67 365 33607 379838 50191314
Klebsiella infection 20.94 10.67 25 33947 7169 50563983
Puerperal pyrexia 20.92 10.67 5 33967 37 50571115
Injection site erythema 19.74 10.67 13 33959 74923 50496229
Sepsis syndrome 19.63 10.67 10 33962 803 50570349
Drug-induced liver injury 19.61 10.67 52 33920 28043 50543109
Acinetobacter infection 19.29 10.67 12 33960 1415 50569737
Stevens-Johnson syndrome 19.15 10.67 44 33928 21708 50549444
Skin odour abnormal 18.95 10.67 12 33960 1460 50569692
Chest crushing 18.92 10.67 3 33969 0 50571152
Musculoskeletal stiffness 18.83 10.67 36 33936 128445 50442707
Swelling of eyelid 18.71 10.67 13 33959 1847 50569305
Blood testosterone increased 18.63 10.67 6 33966 144 50571008
Pseudomonas infection 18.50 10.67 27 33945 9403 50561749
Surgical failure 18.45 10.67 10 33962 911 50570241
Drug intolerance 18.43 10.67 80 33892 219024 50352128
Reaction to azo-dyes 18.42 10.67 4 33968 18 50571134
Skin exfoliation 18.40 10.67 57 33915 33555 50537597
Escherichia infection 18.18 10.67 29 33943 10912 50560240
Erosive oesophagitis 18.11 10.67 12 33960 1577 50569575
Vulval abscess 18.08 10.67 9 33963 688 50570464
Lower respiratory tract infection bacterial 17.95 10.67 7 33965 297 50570855
Wound 17.94 10.67 27 33945 105767 50465385
Bronchial obstruction 17.83 10.67 11 33961 1279 50569873
Documented hypersensitivity to administered product 17.51 10.67 8 33964 505 50570647
Rash erythematous 17.17 10.67 57 33915 34795 50536357
Tubulointerstitial nephritis 17.12 10.67 34 33938 15177 50555975
Respiratory gas exchange disorder 17.07 10.67 7 33965 339 50570813
Antibiotic level below therapeutic 16.93 10.67 4 33968 28 50571124
Drug eruption 16.79 10.67 44 33928 23562 50547590
Face oedema 16.72 10.67 37 33935 17802 50553350
Thyroxine increased 16.68 10.67 8 33964 564 50570588
Gas gangrene 16.67 10.67 5 33967 94 50571058
Venous haemorrhage 16.51 10.67 6 33966 209 50570943
Bartholinitis 16.46 10.67 4 33968 32 50571120
Pneumonia necrotising 16.44 10.67 7 33965 373 50570779
Septic shock 16.43 10.67 79 33893 57096 50514056
Lower respiratory tract infection 16.43 10.67 24 33948 95177 50475975
Weight fluctuation 16.30 10.67 22 33950 7126 50564026
Fibromyalgia 16.21 10.67 5 33967 44973 50526179
Confusional state 16.18 10.67 67 33905 185861 50385291
Hypoglossal nerve paresis 16.06 10.67 5 33967 107 50571045
Hypoglycaemia 15.96 10.67 8 33964 53573 50517579
Rash macular 15.88 10.67 38 33934 19239 50551913
Headache 15.87 10.67 242 33730 506293 50064859
Wound secretion 15.87 10.67 16 33956 3801 50567351
Haemodynamic instability 15.78 10.67 23 33949 8001 50563151
Angioedema 15.45 10.67 58 33914 37618 50533534
Pneumothorax 15.35 10.67 31 33941 14003 50557149
Bile output increased 15.32 10.67 4 33968 44 50571108
Coagulation factor decreased 15.24 10.67 4 33968 45 50571107
Adrenocorticotropic hormone deficiency 15.22 10.67 6 33966 262 50570890
Treatment failure 15.06 10.67 45 33927 137592 50433560
Megacolon 15.03 10.67 11 33961 1695 50569457
Coagulation factor deficiency 15.03 10.67 3 33969 8 50571144
Geotrichum infection 15.01 10.67 7 33965 463 50570689
Sphingomonas paucimobilis infection 15 10.67 4 33968 48 50571104
Coma 14.80 10.67 10 33962 56869 50514283
Cholestasis 14.77 10.67 44 33928 25357 50545795
Perihepatic discomfort 14.77 10.67 3 33969 9 50571143
Toxic shock syndrome 14.71 10.67 7 33965 485 50570667
Breast abscess 14.62 10.67 10 33962 1385 50569767
Overdose 14.56 10.67 28 33944 99699 50471453
Abdominal wall disorder 14.50 10.67 5 33967 149 50571003
Weight increased 14.49 10.67 78 33894 201813 50369339
Subcutaneous abscess 14.27 10.67 17 33955 4865 50566287
Prothrombin time prolonged 14.10 10.67 23 33949 8815 50562337
Congenital lymphoedema 14.10 10.67 3 33969 12 50571140
Serratia infection 14.05 10.67 8 33964 802 50570350
Oesophageal discomfort 13.87 10.67 5 33967 170 50570982
Pneumomediastinum 13.86 10.67 9 33963 1144 50570008
Factor V inhibition 13.85 10.67 5 33967 171 50570981
Fall 13.81 10.67 151 33821 334781 50236371
Chronic respiratory disease 13.71 10.67 4 33968 68 50571084
Tooth extraction 13.65 10.67 23 33949 9052 50562100
Joint vibration 13.56 10.67 3 33969 15 50571137
Infection protozoal 13.39 10.67 3 33969 16 50571136
Adenocarcinoma 13.36 10.67 12 33960 2469 50568683
Clostridium test positive 13.14 10.67 11 33961 2061 50569091
Candida infection 12.98 10.67 40 33932 23483 50547669
Necrotising fasciitis 12.87 10.67 12 33960 2592 50568560
Dysbiosis 12.76 10.67 7 33965 653 50570499
Asthenia 12.69 10.67 145 33827 318897 50252255
Liver injury 12.60 10.67 41 33931 24765 50546387
Babesiosis 12.56 10.67 5 33967 224 50570928
Swelling face 12.56 10.67 69 33903 52526 50518626
Lemierre syndrome 12.54 10.67 4 33968 93 50571059
Skin lesion 12.54 10.67 43 33929 26684 50544468
Abscess jaw 12.52 10.67 9 33963 1349 50569803
Lymphadenopathy 12.45 10.67 50 33922 33449 50537703
Iodine allergy 12.37 10.67 7 33965 694 50570458
Spinal muscular atrophy 12.35 10.67 3 33969 24 50571128
Hyperleukocytosis 12.06 10.67 6 33966 458 50570694
Skin reaction 12.00 10.67 25 33947 11543 50559609
Oesophagitis 11.70 10.67 27 33945 13356 50557796
Skin oedema 11.67 10.67 7 33965 774 50570378
Decreased appetite 11.62 10.67 83 33889 200840 50370312
Bronchopulmonary dysplasia 11.56 10.67 5 33967 277 50570875
Chronic kidney disease 11.46 10.67 55 33917 39716 50531436
Necrosis 11.45 10.67 15 33957 4721 50566431
Allergy to metals 11.45 10.67 6 33966 511 50570641
Bradycardia 11.35 10.67 16 33956 64410 50506742
Mycobacterial infection 11.23 10.67 9 33963 1587 50569565
Product use in unapproved indication 11.20 10.67 123 33849 115696 50455456
Infected skin ulcer 11.08 10.67 10 33962 2071 50569081
Abdominal sepsis 10.97 10.67 8 33964 1227 50569925
Purulent discharge 10.91 10.67 14 33958 4318 50566834
Tracheal haemorrhage 10.88 10.67 4 33968 144 50571008
Therapy interrupted 10.87 10.67 34 33938 20118 50551034
Anaphylactic shock 10.87 10.67 34 33938 20121 50551031
Multi-organ disorder 10.86 10.67 8 33964 1245 50569907
Acute febrile neutrophilic dermatosis 10.85 10.67 11 33961 2631 50568521
Tooth infection 10.76 10.67 27 33945 14085 50557067

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 697.91 11.89 482 19554 67924 29486567
Rash maculo-papular 294.48 11.89 191 19845 24098 29530393
Type IV hypersensitivity reaction 213.33 11.89 63 19973 1111 29553380
Acute generalised exanthematous pustulosis 174.20 11.89 82 19954 5501 29548990
Rash 171.89 11.89 389 19647 189430 29365061
Drug reaction with eosinophilia and systemic symptoms 128.08 11.89 124 19912 27868 29526623
Kounis syndrome 63.69 11.89 29 20007 1800 29552691
Clostridium difficile colitis 63.17 11.89 60 19976 13152 29541339
Toxic skin eruption 61.92 11.89 52 19984 9705 29544786
Pseudomembranous colitis 59.72 11.89 31 20005 2566 29551925
Pruritus 50.63 11.89 184 19852 116665 29437826
Drug ineffective 49.79 11.89 417 19619 362753 29191738
Drug eruption 49.69 11.89 59 19977 16682 29537809
Death 48.99 11.89 99 19937 341985 29212506
Hepatocellular injury 47.46 11.89 65 19971 21178 29533313
Graft infection 45.67 11.89 15 20021 380 29554111
Oesophageal ulcer 43.91 11.89 27 20009 3093 29551398
Methaemoglobinaemia 42.47 11.89 25 20011 2646 29551845
Abscess 38.63 11.89 40 19996 9722 29544769
Cholestasis 38.34 11.89 62 19974 23400 29531091
Dermatitis allergic 37.51 11.89 31 20005 5657 29548834
Electrocardiogram U wave present 34.91 11.89 7 20029 19 29554472
Rash erythematous 32.57 11.89 55 19981 21507 29532984
Pyrexia 32.50 11.89 317 19719 287305 29267186
Surgical failure 32.21 11.89 8 20028 70 29554421
Tubulointerstitial nephritis 32.12 11.89 49 19987 17594 29536897
Erythema 30.97 11.89 117 19919 75489 29479002
Abscess of salivary gland 30.88 11.89 6 20030 13 29554478
Drug abuse 30.88 11.89 8 20028 79875 29474616
Acute kidney injury 30.76 11.89 294 19742 264973 29289518
Glomerulosclerosis 30.17 11.89 13 20023 707 29553784
Necrotising fasciitis 30.16 11.89 22 20014 3343 29551148
Pathogen resistance 29.88 11.89 32 20004 8084 29546407
Cellulitis 29.72 11.89 83 19953 45757 29508734
Eosinophilia 28.90 11.89 53 19983 22108 29532383
Hyper IgE syndrome 28.74 11.89 7 20029 56 29554435
Venolymphatic malformation 28.35 11.89 6 20030 23 29554468
Urticaria 27.92 11.89 91 19945 54569 29499922
Hidradenitis 26.67 11.89 12 20024 724 29553767
Staphylococcal infection 26.34 11.89 60 19976 29180 29525311
Resorption bone increased 26.18 11.89 8 20028 159 29554332
Rash pustular 25.71 11.89 23 20013 4668 29549823
Stevens-Johnson syndrome 24.80 11.89 42 19994 16455 29538036
Vascular purpura 24.61 11.89 14 20022 1389 29553102
Pneumatosis intestinalis 24.58 11.89 19 20017 3150 29551341
Overgrowth bacterial 24.45 11.89 7 20029 110 29554381
Cutaneous vasculitis 24.06 11.89 19 20017 3249 29551242
Mucormycosis 23.84 11.89 23 20013 5135 29549356
Mononucleosis syndrome 23.53 11.89 6 20030 59 29554432
Renal hypoplasia 23.35 11.89 6 20030 61 29554430
Skin graft failure 23.01 11.89 7 20029 137 29554354
Megacolon 22.87 11.89 14 20022 1591 29552900
Calcium deficiency 22.46 11.89 7 20029 149 29554342
Osteomyelitis 22.08 11.89 36 20000 13673 29540818
Hypersensitivity vasculitis 21.99 11.89 18 20018 3239 29551252
Osteomyelitis salmonella 21.93 11.89 5 20031 29 29554462
Clostridium test positive 21.65 11.89 15 20021 2102 29552389
Anamnestic reaction 20.76 11.89 5 20031 38 29554453
Pouchitis 19.10 11.89 9 20027 604 29553887
Gastrointestinal mucosa hyperaemia 18.82 11.89 7 20029 258 29554233
Toxicity to various agents 18.72 11.89 58 19978 173603 29380888
Antibiotic level below therapeutic 18.41 11.89 5 20031 64 29554427
Oesophagitis ulcerative 18.21 11.89 9 20027 671 29553820
Drug resistance 18.08 11.89 43 19993 21497 29532994
Fatigue 17.67 11.89 134 19902 316687 29237804
Vitamin A deficiency 17.57 11.89 4 20032 23 29554468
Swelling face 17.49 11.89 41 19995 20309 29534182
Kidney fibrosis 17.48 11.89 13 20023 2034 29552457
Rash morbilliform 17.30 11.89 14 20022 2479 29552012
Cardiac failure congestive 17.09 11.89 16 20020 76565 29477926
Infectious mononucleosis 17.02 11.89 8 20028 534 29553957
Intentional overdose 16.63 11.89 3 20033 38525 29515966
Urine alcohol test positive 16.54 11.89 4 20032 31 29554460
Allergic reaction to excipient 16.54 11.89 4 20032 31 29554460
Pulmonary venous thrombosis 16.48 11.89 5 20031 97 29554394
Drug clearance increased 16.43 11.89 5 20031 98 29554393
Polycystic liver disease 16.21 11.89 4 20032 34 29554457
Rash pruritic 15.99 11.89 42 19994 22321 29532170
Oesophagitis chemical 15.91 11.89 4 20032 37 29554454
Post procedural fistula 15.63 11.89 4 20032 40 29554451
Anal ulcer 15.55 11.89 8 20028 650 29553841
Multiple organ dysfunction syndrome 15.52 11.89 84 19952 63032 29491459
Agranulocytosis 15.37 11.89 39 19997 20301 29534190
Vitamin B1 deficiency 15.28 11.89 6 20030 257 29554234
Atrioventricular block 15.04 11.89 21 20015 6961 29547530
Cerebrovascular accident 15.00 11.89 18 20018 76893 29477598
Proctitis 14.92 11.89 12 20024 2107 29552384
Oesophagitis 14.90 11.89 28 20008 11895 29542596
Drug ineffective for unapproved indication 14.88 11.89 31 20005 14183 29540308
Sialoadenitis 14.78 11.89 7 20029 475 29554016
Electrocardiogram U-wave abnormality 14.74 11.89 4 20032 51 29554440
Fungal infection 14.51 11.89 30 20006 13655 29540836
Vertical infection transmission 14.50 11.89 3 20033 10 29554481
Erysipelas 14.40 11.89 16 20020 4209 29550282
Pulmonary function test 14.07 11.89 3 20033 12 29554479
Diarrhoea 14.06 11.89 309 19727 332389 29222102
Folate deficiency 14.04 11.89 9 20027 1108 29553383
Myocardial infarction 13.99 11.89 34 20002 110262 29444229
Drug-induced liver injury 13.82 11.89 39 19997 21616 29532875
Completed suicide 13.82 11.89 25 20011 90221 29464270
Headache 13.67 11.89 66 19970 173941 29380550
Microangiopathic haemolytic anaemia 13.58 11.89 8 20028 847 29553644
Arthrofibrosis 13.52 11.89 4 20032 71 29554420
Urinary tract infection fungal 13.41 11.89 6 20030 357 29554134
Magnesium deficiency 13.41 11.89 4 20032 73 29554418
Dermatitis exfoliative 13.36 11.89 19 20017 6406 29548085
Coma 13.36 11.89 5 20031 39445 29515046
Vasculitis necrotising 13.28 11.89 7 20029 598 29553893
Overdose 13.24 11.89 21 20015 79798 29474693
Purpura 13.21 11.89 23 20013 9209 29545282
Pancytopenia 13.19 11.89 99 19937 83069 29471422
Medical device site joint infection 13.16 11.89 4 20032 78 29554413
Leg amputation 13.09 11.89 11 20025 2053 29552438
Post infection glomerulonephritis 13.07 11.89 3 20033 18 29554473
Micturition frequency decreased 12.99 11.89 5 20031 203 29554288
Dry gangrene 12.99 11.89 6 20030 385 29554106
Device toxicity 12.93 11.89 3 20033 19 29554472
Toxic epidermal necrolysis 12.89 11.89 34 20002 18119 29536372
Cholestatic liver injury 12.78 11.89 10 20026 1687 29552804
Toxic shock syndrome streptococcal 12.67 11.89 3 20033 21 29554470
Escherichia infection 12.61 11.89 19 20017 6745 29547746
Septic shock 12.61 11.89 79 19957 62481 29492010
Staphylococcal sepsis 12.58 11.89 22 20014 8840 29545651
Liver injury 12.51 11.89 27 20009 12663 29541828
Eyelid function disorder 12.32 11.89 3 20033 24 29554467
Essential tremor 12.12 11.89 7 20029 715 29553776
Suicide attempt 12.10 11.89 4 20032 34106 29520385
Aeromonas infection 11.96 11.89 5 20031 252 29554239
Acute febrile neutrophilic dermatosis 11.91 11.89 8 20028 1066 29553425
Limb fracture 11.91 11.89 3 20033 28 29554463

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1331.11 10.76 1168 41997 236647 64218920
Rash maculo-papular 501.73 10.76 340 42825 46686 64408881
Acute generalised exanthematous pustulosis 467.65 10.76 215 42950 13843 64441724
Type IV hypersensitivity reaction 333.90 10.76 114 43051 3308 64452259
Rash 289.96 10.76 814 42351 457735 63997832
Drug reaction with eosinophilia and systemic symptoms 220.43 10.76 224 42941 53993 64401574
Toxic skin eruption 206.85 10.76 140 43025 19144 64436423
Clostridium difficile colitis 130.24 10.76 123 43042 27100 64428467
Graft infection 106.92 10.76 32 43133 599 64454968
Abscess 95.75 10.76 89 43076 19215 64436352
Pruritus 94.12 10.76 436 42729 311964 64143603
Pseudomembranous colitis 92.11 10.76 51 43114 4865 64450702
Clostridium difficile infection 91.67 10.76 117 43048 36046 64419521
Urticaria 89.08 10.76 258 42907 147059 64308508
Hidradenitis 84.94 10.76 38 43127 2291 64453276
Drug resistance 80.33 10.76 108 43057 34994 64420573
Symmetrical drug-related intertriginous and flexural exanthema 77.85 10.76 25 43140 596 64454971
Eosinophilia 72.09 10.76 107 43058 37969 64417598
Erythema 68.44 10.76 277 42888 186793 64268774
Pyrexia 68.19 10.76 620 42545 558024 63897543
Cellulitis 66.48 10.76 174 42991 93483 64362084
Oesophageal ulcer 66.37 10.76 45 43120 6165 64449402
Drug abuse 63.90 10.76 7 43158 132367 64323200
Death 63.07 10.76 144 43021 482561 63973006
Pathogen resistance 60.61 10.76 57 43108 12486 64443081
Loss of employment 59.76 10.76 28 43137 1879 64453688
Rash erythematous 54.15 10.76 108 43057 48525 64407042
Cholestasis 54.04 10.76 103 43062 44769 64410798
Drug ineffective 53.97 10.76 824 42341 839423 63616144
Drug eruption 52.51 10.76 90 43075 36046 64419521
Multiple organ dysfunction syndrome 50.45 10.76 166 42999 101247 64354320
Tubulointerstitial nephritis 50.29 10.76 81 43084 30828 64424739
Kounis syndrome 50.23 10.76 29 43136 2996 64452571
Synovitis 48.43 10.76 5 43160 99085 64356482
Staphylococcal infection 47.63 10.76 105 43060 50573 64404994
Stevens-Johnson syndrome 46.77 10.76 83 43082 34166 64421401
Surgical failure 45.83 10.76 18 43147 781 64454786
Acute kidney injury 44.18 10.76 477 42688 448763 64006804
Toxic epidermal necrolysis 43.15 10.76 84 43081 37082 64418485
Toxicity to various agents 43.06 10.76 114 43051 363399 64092168
Methaemoglobinaemia 42.91 10.76 30 43135 4318 64451249
Rheumatoid arthritis 38.53 10.76 32 43133 164262 64291305
Rash morbilliform 38.42 10.76 30 43135 5111 64450456
Hepatocellular injury 38.37 10.76 90 43075 45145 64410422
Completed suicide 38.06 10.76 57 43108 224357 64231210
Antibiotic level below therapeutic 37.29 10.76 9 43156 70 64455497
Joint swelling 37.22 10.76 54 43111 215328 64240239
Diarrhoea 36.49 10.76 682 42483 722022 63733545
Leukocytosis 36.38 10.76 79 43086 37661 64417906
Drug-induced liver injury 35.32 10.76 90 43075 47553 64408014
Clostridium test positive 35.13 10.76 26 43139 4089 64451478
Type I hypersensitivity 33.74 10.76 24 43141 3550 64452017
Intentional overdose 32.27 10.76 10 43155 89934 64365633
Escherichia infection 32.17 10.76 45 43120 15123 64440444
Megacolon 32.14 10.76 22 43143 3060 64452507
Oesophagitis 30.28 10.76 53 43112 21577 64433990
Necrotising fasciitis 29.24 10.76 26 43139 5300 64450267
Mucormycosis 29.20 10.76 30 43135 7311 64448256
Tubo-ovarian abscess 29.09 10.76 10 43155 296 64455271
Rash macular 28.06 10.76 54 43111 23631 64431936
Abscess of salivary gland 28.02 10.76 6 43159 25 64455542
Hepatitis infectious mononucleosis 27.96 10.76 8 43157 127 64455440
Coma 27.62 10.76 12 43153 87603 64367964
Face oedema 27.57 10.76 55 43110 24706 64430861
Overdose 27.56 10.76 40 43125 159526 64296041
Pseudomonas infection 26.58 10.76 45 43120 17838 64437729
Purpura 26.44 10.76 44 43121 17202 64438365
Vascular purpura 26.08 10.76 18 43147 2538 64453029
Septic shock 25.86 10.76 139 43026 105298 64350269
Fatigue 25.76 10.76 350 42815 748380 63707187
Osteomyelitis 25.74 10.76 57 43108 27530 64428037
Pneumococcal infection 25.56 10.76 12 43153 809 64454758
Toxic shock syndrome streptococcal 25.55 10.76 7 43158 94 64455473
Abscess neck 25.53 10.76 13 43152 1046 64454521
Mastitis 25.38 10.76 16 43149 1938 64453629
Pemphigus 25.16 10.76 5 43160 60696 64394871
Rash pustular 25.07 10.76 32 43133 9853 64445714
Electrocardiogram U wave present 24.24 10.76 7 43158 115 64455452
Acute febrile neutrophilic dermatosis 23.96 10.76 19 43146 3310 64452257
Glomerulosclerosis 23.71 10.76 12 43153 953 64454614
Glossodynia 23.56 10.76 7 43158 64689 64390878
Anti-cyclic citrullinated peptide antibody positive 22.97 10.76 3 43162 49559 64406008
Sialoadenitis 22.80 10.76 14 43151 1619 64453948
Premature delivery 22.78 10.76 43 43122 18546 64437021
Overgrowth bacterial 22.68 10.76 7 43158 146 64455421
Hand deformity 22.48 10.76 7 43158 62764 64392803
Hypersensitivity vasculitis 22.26 10.76 25 43140 6736 64448831
Swelling face 21.90 10.76 88 43077 59078 64396489
Type IIb hyperlipidaemia 21.84 10.76 5 43160 30 64455537
Anamnestic reaction 21.57 10.76 5 43160 32 64455535
Swelling of eyelid 21.34 10.76 15 43150 2177 64453390
Puerperal pyrexia 21.30 10.76 5 43160 34 64455533
Drug ineffective for unapproved indication 21.22 10.76 57 43108 31076 64424491
Necrotising oesophagitis 21.22 10.76 10 43155 680 64454887
Erosive oesophagitis 21.21 10.76 16 43149 2590 64452977
Skin exfoliation 21 10.76 72 43093 44813 64410754
Erysipelas 20.86 10.76 28 43137 9053 64446514
Klebsiella infection 20.51 10.76 34 43131 13247 64442320
Osteomyelitis salmonella 20.27 10.76 5 43160 43 64455524
Skin graft failure 20.00 10.76 7 43158 219 64455348
Mononucleosis syndrome 19.82 10.76 6 43159 117 64455450
Cutaneous vasculitis 19.73 10.76 23 43142 6450 64449117
Reaction to azo-dyes 19.70 10.76 4 43161 12 64455555
Liver injury 19.60 10.76 54 43111 29878 64425689
Gas gangrene 19.56 10.76 7 43158 234 64455333
Vulval abscess 19.08 10.76 9 43156 613 64454954
Suicide attempt 19.02 10.76 12 43153 70995 64384572
Candida infection 18.93 10.76 55 43110 31364 64424203
Injection site erythema 18.92 10.76 12 43153 70788 64384779
Peripheral swelling 18.86 10.76 74 43091 209079 64246488
Toxic shock syndrome 18.85 10.76 10 43155 876 64454691
Fungal infection 18.78 10.76 58 43107 34193 64421374
Dermatitis allergic 18.58 10.76 35 43130 15074 64440493
Agranulocytosis 18.48 10.76 62 43103 38167 64417400
Insomnia 18.48 10.76 69 43096 197767 64257800
Headache 18.34 10.76 247 42918 529220 63926347
Cholestatic liver injury 18.31 10.76 17 43148 3662 64451905
Anaphylactic shock 18.18 10.76 53 43112 30275 64425292
Odynophagia 18.11 10.76 27 43138 9614 64445953
Cerebrovascular accident 17.94 10.76 41 43124 137542 64318025
Confusional state 17.90 10.76 102 43063 261042 64194525
Osteonecrosis of jaw 17.86 10.76 63 43102 39762 64415805
Acute respiratory distress syndrome 17.82 10.76 62 43103 38873 64416694
Angioedema 17.60 10.76 85 43080 61736 64393831
Pericarditis 17.54 10.76 10 43155 62506 64393061
Urine alcohol test positive 17.33 10.76 4 43161 25 64455542
Systemic lupus erythematosus 17.12 10.76 16 43149 77596 64377971
Bartholinitis 17.07 10.76 4 43161 27 64455540
Vasculitis necrotising 17.07 10.76 10 43155 1062 64454505
Acute hepatic failure 16.99 10.76 47 43118 26065 64429502
Proctitis 16.51 10.76 15 43150 3144 64452423
Ophthalmoplegia 16.46 10.76 14 43151 2688 64452879
Tremor 16.39 10.76 48 43117 148182 64307385
Helicobacter infection 16.24 10.76 3 43162 38359 64417208
Asthenia 16.18 10.76 196 42969 427848 64027719
Lymphadenopathy 16.14 10.76 68 43097 46618 64408949
Fall 16.08 10.76 190 42975 416636 64038931
Pulmonary venous thrombosis 16.03 10.76 5 43160 108 64455459
Hypoglossal nerve paresis 15.95 10.76 5 43160 110 64455457
Somnolence 15.94 10.76 76 43089 203569 64251998
Haemolytic anaemia 15.92 10.76 34 43131 16019 64439548
Post procedural fistula 15.88 10.76 6 43159 234 64455333
Muscle necrosis 15.85 10.76 10 43155 1213 64454354
Pancytopenia 15.84 10.76 156 43009 143153 64312414
Anaphylactic reaction 15.81 10.76 89 43076 68575 64386992
Lemierre syndrome 15.78 10.76 5 43160 114 64455453
Gastrointestinal mucosa hyperaemia 15.72 10.76 7 43158 417 64455150
Cardio-respiratory arrest 15.71 10.76 26 43139 98367 64357200
Skin reaction 15.67 10.76 29 43136 12323 64443244
Gastric disorder 15.60 10.76 49 43116 29148 64426419
Thyroxine increased 15.52 10.76 8 43157 660 64454907
Leg amputation 15.47 10.76 15 43150 3412 64452155
Oesophageal discomfort 15.44 10.76 6 43159 253 64455314
Sepsis syndrome 15.42 10.76 10 43155 1271 64454296
Clostridial infection 15.29 10.76 18 43147 5101 64450466
Venous haemorrhage 15.28 10.76 6 43159 260 64455307
Prothrombin time prolonged 15.22 10.76 33 43132 15708 64439859
Clostridium colitis 15.22 10.76 13 43152 2512 64453055
Bile output increased 15.17 10.76 4 43161 46 64455521
Dizziness 15.13 10.76 200 42965 429963 64025604
Pneumatosis intestinalis 14.98 10.76 18 43147 5211 64450356
Wound secretion 14.97 10.76 18 43147 5214 64450353
Infusion related reaction 14.94 10.76 58 43107 164409 64291158
Drug intolerance 14.81 10.76 70 43095 187922 64267645
Perihepatic discomfort 14.78 10.76 3 43162 9 64455558
Hepatitis cholestatic 14.75 10.76 28 43137 12127 64443440
Myocardial infarction 14.73 10.76 59 43106 165762 64289805
Hyper IgE syndrome 14.69 10.76 7 43158 488 64455079
SAPHO syndrome 14.51 10.76 5 43160 149 64455418
Oesophagitis chemical 14.51 10.76 4 43161 55 64455512
Eye swelling 14.39 10.76 40 43125 22241 64433326
Coagulation factor decreased 14.24 10.76 5 43160 158 64455409
Breast abscess 14.17 10.76 9 43156 1104 64454463
Vitamin A deficiency 14.07 10.76 4 43161 62 64455505
Dermatitis exfoliative 14.02 10.76 25 43140 10327 64445240
Scar 14.01 10.76 29 43136 13369 64442198
Pulmonary function test 13.92 10.76 3 43162 13 64455554
Neoplasm progression 13.91 10.76 5 43160 40959 64414608
Lip swelling 13.90 10.76 50 43115 31857 64423710
Bronchial obstruction 13.85 10.76 12 43153 2362 64453205
Resorption bone increased 13.77 10.76 9 43156 1159 64454408
Documented hypersensitivity to administered product 13.74 10.76 8 43157 840 64454727
Gastrointestinal bacterial overgrowth 13.63 10.76 6 43159 348 64455219
Acinetobacter infection 13.62 10.76 12 43153 2417 64453150
Joint vibration 13.57 10.76 3 43162 15 64455552
Bursitis infective 13.55 10.76 9 43156 1191 64454376
Acute myocardial infarction 13.55 10.76 16 43149 69702 64385865
Arthropathy 13.49 10.76 39 43126 120928 64334639
Alopecia 13.46 10.76 61 43104 165629 64289938
Accidental overdose 13.42 10.76 3 43162 33554 64422013
Infected skin ulcer 13.37 10.76 13 43152 2967 64452600
Scedosporium infection 13.19 10.76 9 43156 1245 64454322
Sensory disturbance 13.13 10.76 28 43137 13180 64442387
Infection protozoal 13.11 10.76 3 43162 18 64455549
Symptom recurrence 13.06 10.76 8 43157 921 64454646
Hepatic steatosis 13.01 10.76 48 43117 30959 64424608
Post infection glomerulonephritis 12.97 10.76 3 43162 19 64455548
Device toxicity 12.97 10.76 3 43162 19 64455548
International normalised ratio increased 12.90 10.76 94 43071 79073 64376494
Polycystic liver disease 12.89 10.76 4 43161 85 64455482
Haemorrhagic vasculitis 12.80 10.76 4 43161 87 64455480
Postoperative wound infection 12.78 10.76 24 43141 10312 64445255
Weight increased 12.72 10.76 87 43078 213261 64242306
Electrocardiogram U-wave abnormality 12.72 10.76 4 43161 89 64455478
Infectious mononucleosis 12.70 10.76 10 43155 1723 64453844
Abscess limb 12.65 10.76 18 43147 6143 64449424
Lower respiratory tract infection bacterial 12.65 10.76 7 43158 667 64454900
Medication error 12.63 10.76 9 43156 49957 64405610
Lower respiratory tract infection 12.49 10.76 28 43137 94586 64360981
Gait disturbance 12.47 10.76 66 43099 172089 64283478
Drug clearance increased 12.43 10.76 5 43160 231 64455336
Cerebral toxoplasmosis 12.24 10.76 10 43155 1816 64453751
Dysarthria 12.23 10.76 13 43152 59393 64396174
Subcutaneous abscess 12.18 10.76 19 43146 7034 64448533
Sphingomonas paucimobilis infection 12.13 10.76 4 43161 104 64455463
Decreased appetite 12.11 10.76 125 43040 281164 64174403
Calcium deficiency 12.05 10.76 7 43158 731 64454836
Skin odour abnormal 12.05 10.76 10 43155 1857 64453710
Skin oedema 12.03 10.76 9 43156 1439 64454128
Haemodynamic instability 11.92 10.76 29 43136 14883 64440684
Upper respiratory tract infection bacterial 11.85 10.76 4 43161 112 64455455
Respiratory gas exchange disorder 11.82 10.76 7 43158 758 64454809
Arthrofibrosis 11.78 10.76 4 43161 114 64455453
Anal ulcer 11.76 10.76 8 43157 1101 64454466
Skin infection 11.76 10.76 29 43136 15008 64440559
Abdominal wall disorder 11.75 10.76 5 43160 267 64455300
Skin disorder 11.74 10.76 43 43122 27637 64427930
Serratia infection 11.68 10.76 9 43156 1504 64454063
Tooth extraction 11.51 10.76 22 43143 9579 64445988
Candida osteomyelitis 11.50 10.76 3 43162 33 64455534
Gastrointestinal submucosal tumour 11.49 10.76 4 43161 123 64455444
Babesiosis 11.49 10.76 5 43160 282 64455285
Vulvovaginal discomfort 11.46 10.76 9 43156 1546 64454021
Limb fracture 11.42 10.76 3 43162 34 64455533
Pouchitis 11.34 10.76 7 43158 817 64454750
Intracranial mass 11.27 10.76 10 43155 2033 64453534
Hypoglobulinaemia 11.26 10.76 3 43162 36 64455531
Weight fluctuation 11.21 10.76 20 43145 8262 64447305
Idiosyncratic drug reaction 11.20 10.76 8 43157 1191 64454376
Aspergillus infection 11.17 10.76 30 43135 16349 64439218
Kidney fibrosis 11.13 10.76 12 43153 3089 64452478
Rash pruritic 11.04 10.76 71 43094 57333 64398234
Vitamin B1 deficiency 10.82 10.76 6 43159 574 64454993
Urinary tract infection fungal 10.81 10.76 7 43158 888 64454679
Eosinophil count increased 10.81 10.76 27 43138 14085 64441482
Dysbiosis 10.81 10.76 7 43158 888 64454679

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D10AF01 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
ATC D10AF51 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
ATC G01AA10 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
ATC J01FF01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Lincosamides
FDA CS M0515779 Lincosamides
FDA PE N0000009982 Decreased Sebaceous Gland Activity
FDA EPC N0000175443 Lincosamide Antibacterial
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
FDA PE N0000175731 Neuromuscular Blockade

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Anaerobic septicemia indication 1976008
Bacterial septicemia indication 10001005 DOID:0040085
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Streptococcal septicemia indication 29577008
Pneumonia due to Streptococcus indication 34020007
Empyema of pleura indication 58554001 DOID:3798
Acne vulgaris indication 88616000
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Infectious disease of abdomen indication 128070006
Pneumococcal pneumonia indication 233607000
Gas gangrene caused by clostridium perfringens indication 266093005
Streptococcus pyogenes infection indication 302809008
Infectious disorder of joint indication 363162000
Infection due to Staphylococcus aureus indication 406602003
Bacterial vaginosis indication 419760006 DOID:3385
Aspiration pneumonia indication 422588002 DOID:3240
Infection due to anaerobic bacteria indication 423451008
Osteomyelitis due to Staphylococcus aureus indication 428783003
Inflammatory Disease of Female Pelvic Organs indication
Anaerobic Joint Infection indication
Anaerobic Tubo-Ovarian Abscess indication
Prevention of Bacterial Endocarditis indication
Anaerobic Peritonitis indication
Clostridium Perfringens Empyema indication
Anaerobic Pelvic Cellulitis indication
Anaerobic Lung Abscess indication
Skin and Skin Structure Anaerobic Infection indication
Bacteroides Endomyometritis indication
Anaerobic Endometritis indication
Intra-Abdominal Anaerobic Abscess indication
Pyrexia of unknown origin off-label use 7520000
Inhalational anthrax off-label use 11389007
Actinomycotic infection off-label use 11817007 DOID:8478
Babesiosis off-label use 21061004 DOID:9643
Sinusitis off-label use 36971009
Erysipelas off-label use 44653001 DOID:11330
Malaria off-label use 61462000 DOID:12365
Acute bacterial sinusitis off-label use 75498004
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Bacterial infection of skin off-label use 128936008
Toxoplasmosis off-label use 187192000 DOID:9965
Diverticulitis of gastrointestinal tract off-label use 271366000
Infective otitis media off-label use 312218008
Rosacea off-label use 398909004 DOID:8881
Anthrax off-label use 409498004 DOID:7427
Pneumocystosis jiroveci pneumonia off-label use 415125002 DOID:11339
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Diabetic Foot Infection off-label use
Chloroquine Resistant Plasmodium Falciparum Malaria off-label use
Encephalitis due to Toxoplasmosis off-label use
Diabetic Foot Infection Due to Gram-Positive Bacteria off-label use
Gardnerella Vaginalis Bacterial Vaginosis off-label use
Sunburn contraindication 23346002
Atopic dermatitis contraindication 24079001 DOID:3310
Crohn's disease contraindication 34000006
Eczema contraindication 43116000
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Candidal vulvovaginitis contraindication 72605008 DOID:2272
Pregnancy, function contraindication 289908002
Pseudomembranous enterocolitis contraindication 397683000
Erythroderma contraindication 399992009
Breastfeeding (mother) contraindication 413712001
Inflammatory dermatosis contraindication 703938007
Bloody Stools contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Skin infections caused by Staphylococcus aureus Indication
Cats Skin infections caused by S intermedius Indication
Cats Skin infections caused by Streptococcus species Indication
Cats Deep wounds and abscesses caused by Clostridium perfringens Indication
Cats Deep wounds and abscesses caused by Bacteroides fragilis Indication
Cats Dental infections caused by Staphylococcus aureus Indication
Cats Dental infections caused by S intermedius Indication
Cats Dental infections caused by Streptococcus species Indication
Cats Dental infections caused by C perfringens Indication
Cats Dental infections caused by B fragilis Indication
Dogs Skin infections caused by coagulase-positive staphylococci Indication
Dogs Deep wounds and abscesses caused by Bacteroides fragilis Indication
Dogs Deep wounds and abscesses caused by Prevotella melaninogenicus Indication
Dogs Deep wounds and abscesses caused by Fusobacterium necrophorum Indication
Dogs Deep wounds and abscesses caused by Clostridium perfringens Indication
Dogs Dental infections caused by Staphylococcus aureus Indication
Dogs Dental infections caused by B fragilis Indication
Dogs Dental infections caused by P melaninogenicus Indication
Dogs Dental infections caused by F necrophorum Indication
Dogs Dental infections caused by C perfringens Indication
Dogs Osteomyelitis caused by Staphylococcus aureus Indication
Dogs Osteomyelitis caused by B fragilis Indication
Dogs Osteomyelitis caused by P melaninogenicus Indication
Dogs Osteomyelitis caused by F necrophorum Indication
Dogs Osteomyelitis caused by C perfringens Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Antirobe Capsules Zoetis Inc. 1
Antirobe Aquadrops Zoetis Inc. 1
Clindamycin Hydrochloride Oral Liquid Cronus Pharma Specialities India Private Limited 1
Clinsol Virbac AH Inc. 1
Clindamycin Hydrochloride Capsules Cronus Pharma Specialities India Private Limited 1
Clintabs Virbac AH Inc. 1
Clindamycin Hydrochloride Oral Drops First Priority Inc. 1
ClindaMed Oral Drops Bimeda Animal Health Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.85 acidic
pKa2 13.38 acidic
pKa3 7.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
50S ribosomal protein L10 Ribosomal protein WOMBAT-PK

External reference:

IDSource
4019683 VUID
N0000147775 NUI
D00277 KEGG_DRUG
21462-39-5 SECONDARY_CAS_RN
2582 RXNORM
4018082 VANDF
4019683 VANDF
C0008947 UMLSCUI
CHEBI:3745 CHEBI
CLY PDB_CHEM_ID
CHEMBL1753 ChEMBL_ID
CHEMBL1200588 ChEMBL_ID
D002981 MESH_DESCRIPTOR_UI
DB01190 DRUGBANK_ID
446598 PUBCHEM_CID
10607 IUPHAR_LIGAND_ID
2550 INN_ID
3U02EL437C UNII
11401 MMSL
4466 MMSL
4467 MMSL
d00043 MMSL
002794 NDDF
002795 NDDF
372786004 SNOMEDCT_US
58883005 SNOMEDCT_US
63084001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0225 CAPSULE 150 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0331 CAPSULE 75 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0395 CAPSULE 300 mg ORAL NDA 27 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1381 CAPSULE 75 mg ORAL ANDA 22 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1382 CAPSULE 150 mg ORAL ANDA 22 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1383 CAPSULE 300 mg ORAL ANDA 22 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-2932 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5708 CAPSULE 150 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0713-3171 CAPSULE 150 mg ORAL ANDA 24 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0713-5256 CAPSULE 300 mg ORAL ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3288 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3289 INJECTION, SOLUTION 12 mg INTRAVENOUS ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3290 INJECTION, SOLUTION 18 mg INTRAVENOUS ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9220 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 23 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9220 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 23 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9221 INJECTION, SOLUTION 12 mg INTRAVENOUS ANDA 23 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9221 INJECTION, SOLUTION 12 mg INTRAVENOUS ANDA 23 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9222 INJECTION, SOLUTION 18 mg INTRAVENOUS ANDA 23 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9222 INJECTION, SOLUTION 18 mg INTRAVENOUS ANDA 23 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-5959 CAPSULE 150 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7194 CAPSULE 300 mg ORAL ANDA 24 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-153 CAPSULE 150 mg ORAL ANDA 25 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-154 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 12634-092 CAPSULE 150 mg ORAL ANDA 24 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16590-057 CAPSULE 150 mg ORAL ANDA 13 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-033 CAPSULE 150 mg ORAL ANDA 25 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-034 CAPSULE 300 mg ORAL ANDA 25 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-159 CAPSULE 150 mg ORAL ANDA 24 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-448 CAPSULE 300 mg ORAL ANDA 24 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-532 CAPSULE 150 mg ORAL ANDA 24 sections