clindamycin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 678 18323-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clindamycin hydrochloride hydrate
  • clindamycin
  • 7-Chloro-7-deoxylincomycin
  • 7-Chlorolincomycin
  • 7-Deoxy-7(S)-chlorolincomycin
  • chlolincocin
  • clincin
  • clinimycin
  • Dalacin C
  • dalacine
  • clindamycin hydrochloride
  • clindamycin HCl
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
  • Molecular weight: 424.98
  • Formula: C18H33ClN2O5S
  • CLOGP: 2.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 102.26
  • ALOGS: -2.14
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g V
1.20 g O
1.80 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 13 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 70.59 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 87 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.79 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 22, 1970 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 3107.09 10.46 2062 34071 241763 46408166
Acute generalised exanthematous pustulosis 335.85 10.46 158 35975 9247 46640682
Rash 243.45 10.46 714 35419 355798 46294131
Rash maculo-papular 219.55 10.46 178 35955 27696 46622233
Urticaria 139.47 10.46 292 35841 117600 46532329
Clostridium difficile infection 136.70 10.46 130 36003 24973 46624956
Toxic skin eruption 121.22 10.46 90 36043 12297 46637632
Drug reaction with eosinophilia and systemic symptoms 118.94 10.46 130 36003 29418 46620511
Type IV hypersensitivity reaction 107.37 10.46 48 36085 2492 46647437
Dermatitis allergic 100.28 10.46 81 36052 12522 46637407
Cellulitis 94.85 10.46 184 35949 70104 46579825
Clostridium difficile colitis 84.16 10.46 87 36046 18466 46631463
Symmetrical drug-related intertriginous and flexural exanthema 79.71 10.46 22 36111 260 46649669
Hidradenitis 70.79 10.46 34 36099 2081 46647848
Pruritus 70.08 10.46 371 35762 241981 46407948
Rheumatoid arthritis 67.92 10.46 52 36081 240163 46409766
Abortion spontaneous 67.27 10.46 121 36012 43525 46606404
Graft infection 65.99 10.46 18 36115 203 46649726
Red man syndrome 62.57 10.46 26 36107 1127 46648802
Eosinophilia 61.27 10.46 75 36058 19142 46630787
Necrotising oesophagitis 56.26 10.46 13 36120 69 46649860
Pathogen resistance 52.60 10.46 41 36092 6019 46643910
Pseudomembranous colitis 52.42 10.46 32 36101 3163 46646766
Death 51.31 10.46 115 36018 335433 46314496
Rash morbilliform 46.48 10.46 29 36104 2980 46646949
Erythema 44.93 10.46 224 35909 142596 46507333
Toxic epidermal necrolysis 43.97 10.46 69 36064 22209 46627720
Drug resistance 43.23 10.46 60 36073 17308 46632621
Drug eruption 40.63 10.46 65 36068 21264 46628665
Anaphylactic reaction 39.45 10.46 110 36023 53002 46596927
Loss of employment 38.46 10.46 19 36114 1237 46648692
Toxic shock syndrome streptococcal 38.12 10.46 10 36123 96 46649833
Abscess 37.63 10.46 50 36083 13839 46636090
Synovitis 36.03 10.46 3 36130 61072 46588857
Toxicity to various agents 34.47 10.46 70 36063 211696 46438233
Osteomyelitis 34.41 10.46 62 36071 22321 46627608
Staphylococcal infection 31.56 10.46 79 36054 35692 46614237
Face oedema 30.65 10.46 54 36079 19099 46630830
Fall 30.51 10.46 141 35992 328956 46320973
Mastitis 30.18 10.46 20 36113 2278 46647651
Upper respiratory tract infection bacterial 29.85 10.46 8 36125 84 46649845
Completed suicide 29.46 10.46 42 36091 145878 46504051
Osteonecrosis of jaw 28.30 10.46 74 36059 34328 46615601
Pyrexia 28.27 10.46 402 35731 348400 46301529
Skin test negative 28.21 10.46 6 36127 20 46649909
Intentional overdose 27.59 10.46 8 36125 64936 46584993
Tubo-ovarian abscess 27.17 10.46 10 36123 312 46649617
Hepatitis cholestatic 26.20 10.46 29 36104 6648 46643281
Diarrhoea 25.22 10.46 588 35545 559014 46090915
Pneumococcal infection 25.21 10.46 10 36123 384 46649545
Fatigue 25.00 10.46 327 35806 608370 46041559
Angioedema 24.92 10.46 77 36056 39265 46610664
Abscess neck 24.73 10.46 11 36122 564 46649365
Clostridial infection 24.50 10.46 23 36110 4342 46645587
Drug-induced liver injury 24.48 10.46 58 36075 25310 46624619
Hepatitis infectious mononucleosis 24.41 10.46 7 36126 96 46649833
Tooth infection 24.16 10.46 38 36095 12248 46637681
Megacolon 22.90 10.46 15 36118 1676 46648253
Pemphigus 22.37 10.46 4 36129 45270 46604659
Lymphadenopathy 21.63 10.46 66 36067 33422 46616507
Antibiotic level below therapeutic 21.41 10.46 5 36128 28 46649901
Necrotising fasciitis 21.16 10.46 17 36116 2606 46647323
Type IIb hyperlipidaemia 21.12 10.46 5 36128 30 46649899
Rash macular 20.76 10.46 46 36087 19214 46630715
Oesophageal discomfort 20.56 10.46 7 36126 173 46649756
Gas gangrene 20.49 10.46 6 36127 89 46649840
Toxic shock syndrome 20.47 10.46 9 36124 449 46649480
Puerperal pyrexia 19.87 10.46 5 36128 40 46649889
Tremor 19.86 10.46 37 36096 115602 46534327
Multiple organ dysfunction syndrome 19.84 10.46 86 36047 51624 46598305
Stevens-Johnson syndrome 19.04 10.46 50 36083 23247 46626682
Lower respiratory tract infection bacterial 19.03 10.46 8 36125 357 46649572
Lemierre syndrome 18.96 10.46 6 36127 117 46649812
Rash pustular 18.85 10.46 25 36108 6904 46643025
Coagulation factor deficiency 18.65 10.46 4 36129 14 46649915
Oesophageal irritation 18.24 10.46 6 36127 133 46649796
Subcutaneous abscess 18.18 10.46 21 36112 5042 46644887
Erosive oesophagitis 18.11 10.46 13 36120 1685 46648244
Rash erythematous 17.96 10.46 63 36070 34287 46615642
Acute kidney injury 17.95 10.46 269 35864 235586 46414343
Swelling face 17.93 10.46 85 36048 52974 46596955
Alopecia 17.88 10.46 65 36068 162349 46487580
Wrong technique in product usage process 17.76 10.46 10 36123 54412 46595517
Blood testosterone increased 17.67 10.46 6 36127 147 46649782
Cholestasis 17.37 10.46 53 36080 26840 46623089
Hand deformity 17.20 10.46 3 36130 34571 46615358
Asthenia 17.16 10.46 156 35977 310919 46339010
Skin odour abnormal 17.05 10.46 12 36121 1507 46648422
Lower respiratory tract infection 16.75 10.46 11 36122 55078 46594851
Tubulointerstitial nephritis 16.71 10.46 36 36097 14752 46635177
Off label use 16.68 10.46 201 35932 379640 46270289
Surgical failure 16.65 10.46 10 36123 960 46648969
Cerebral toxoplasmosis 16.53 10.46 9 36124 717 46649212
Acne cystic 16.37 10.46 7 36126 326 46649603
Hypoglycaemia 16.32 10.46 11 36122 54338 46595591
Pneumonia necrotising 16.23 10.46 7 36126 333 46649596
Nephropathy toxic 15.99 10.46 24 36109 7430 46642499
Coma 15.99 10.46 13 36120 58336 46591593
Leukocytosis 15.95 10.46 47 36086 23351 46626578
Skin oedema 15.47 10.46 9 36124 814 46649115
Documented hypersensitivity to administered product 15.43 10.46 8 36125 577 46649352
Abscess jaw 15.22 10.46 11 36122 1441 46648488
Injury 15.22 10.46 71 36062 43956 46605973
Respiratory gas exchange disorder 15.21 10.46 7 36126 389 46649540
Systemic lupus erythematosus 14.97 10.46 17 36116 65163 46584766
Sepsis syndrome 14.88 10.46 9 36124 875 46649054
Bile output increased 14.84 10.46 4 36129 43 46649886
Acute febrile neutrophilic dermatosis 14.79 10.46 14 36119 2671 46647258
Fibromyalgia 14.58 10.46 5 36128 36458 46613471
Hypoglossal nerve paresis 14.56 10.46 5 36128 127 46649802
Injection site erythema 14.45 10.46 22 36111 74405 46575524
Infusion related reaction 14.37 10.46 36 36097 101172 46548757
Pneumonia 14.37 10.46 205 35928 376115 46273814
Perihepatic discomfort 14.34 10.46 3 36130 9 46649920
Breast abscess 14.16 10.46 10 36123 1263 46648666
Acute respiratory distress syndrome 13.96 10.46 43 36090 21879 46628050
Somnolence 13.91 10.46 68 36065 156453 46493476
Coagulation factor decreased 13.87 10.46 4 36129 56 46649873
Dizziness 13.86 10.46 183 35950 340231 46309698
Weight fluctuation 13.84 10.46 21 36112 6563 46643366
Wound secretion 13.77 10.46 16 36117 3864 46646065
Liver injury 13.75 10.46 35 36098 15966 46633963
Joint swelling 13.72 10.46 74 36059 165999 46483930
Congenital lymphoedema 13.68 10.46 3 36130 12 46649917
Skin exfoliation 13.58 10.46 56 36077 32882 46617047
Oesophageal ulcer 13.51 10.46 16 36117 3945 46645984
Acute hepatic failure 13.49 10.46 33 36100 14688 46635241
Factor V inhibition 13.41 10.46 5 36128 162 46649767
Plasma cell myeloma 13.36 10.46 9 36124 44469 46605460
Purpura 13.33 10.46 26 36107 9932 46639997
Skin ulcer 13.23 10.46 55 36078 32403 46617526
Overdose 13.18 10.46 38 36095 101941 46547988
Acinetobacter infection 13.17 10.46 10 36123 1412 46648517
Thyroxine increased 13.15 10.46 7 36126 533 46649396
Headache 12.99 10.46 277 35856 478075 46171854
Oesophagitis 12.94 10.46 31 36102 13620 46636309
Abdominal wall disorder 12.94 10.46 5 36128 179 46649750
Tooth extraction 12.90 10.46 26 36107 10167 46639762
Premature delivery 12.88 10.46 42 36091 22027 46627902
Confusional state 12.79 10.46 72 36061 159820 46490109
Venous haemorrhage 12.78 10.46 5 36128 185 46649744
Skin reaction 12.77 10.46 27 36106 10919 46639010
Clostridium test positive 12.59 10.46 11 36122 1893 46648036
Type I hypersensitivity 12.48 10.46 12 36121 2334 46647595
Pain in extremity 12.47 10.46 134 35999 258546 46391383
Adenocarcinoma 12.42 10.46 12 36121 2347 46647582
Adrenocorticotropic hormone deficiency 12.41 10.46 5 36128 200 46649729
Septic shock 12.38 10.46 82 36051 57811 46592118
Multi-organ disorder 12.38 10.46 9 36124 1189 46648740
Joint vibration 12.27 10.46 3 36130 21 46649908
Pneumomediastinum 12.23 10.46 9 36124 1212 46648717
Abdominal wall haematoma 12.15 10.46 13 36120 2868 46647061
Infection protozoal 12.15 10.46 3 36130 22 46649907
Glossodynia 12.01 10.46 10 36123 44363 46605566
Injection site pruritus 11.99 10.46 8 36125 39735 46610194
Lip swelling 11.94 10.46 45 36088 25350 46624579
Sialoadenitis 11.85 10.46 9 36124 1271 46648658
Hyperleukocytosis 11.74 10.46 6 36127 420 46649509
Acne 11.71 10.46 38 36095 19881 46630048
Dermatitis exfoliative 11.69 10.46 18 36115 5698 46644231
Bronchial obstruction 11.59 10.46 9 36124 1313 46648616
Pneumothorax 11.55 10.46 31 36102 14598 46635331
Osteolysis 11.40 10.46 12 36121 2600 46647329
Methaemoglobinaemia 11.39 10.46 11 36122 2151 46647778
Gastrointestinal bacterial overgrowth 11.38 10.46 5 36128 249 46649680
Haemodynamic instability 11.36 10.46 21 36112 7704 46642225
Anaphylactic shock 11.31 10.46 38 36095 20236 46629693
Acarodermatitis 11.27 10.46 7 36126 713 46649216
Cerebral haemorrhage 11.15 10.46 4 36129 28367 46621562
Skin test positive 11.03 10.46 7 36126 741 46649188
Odynophagia 10.94 10.46 19 36114 6643 46643286
Suicide attempt 10.94 10.46 16 36117 55020 46594909
Contraindicated product administered 10.91 10.46 29 36104 79918 46570011
Root canal infection 10.86 10.46 4 36129 125 46649804
Therapy interrupted 10.77 10.46 25 36108 10766 46639163
Clostridium colitis 10.72 10.46 10 36123 1872 46648057
Hypertensive urgency 10.54 10.46 4 36129 136 46649793
Head injury 10.52 10.46 3 36130 24633 46625296
Spinal muscular atrophy 10.47 10.46 3 36130 41 46649888

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 692.97 11.37 504 22443 68015 29861516
Rash maculo-papular 309.66 11.37 210 22737 25208 29904323
Rash 218.54 11.37 464 22483 191425 29738106
Type IV hypersensitivity reaction 207.07 11.37 63 22884 1085 29928446
Acute generalised exanthematous pustulosis 187.02 11.37 92 22855 6006 29923525
Drug reaction with eosinophilia and systemic symptoms 122.28 11.37 129 22818 28359 29901172
Toxic skin eruption 80.33 11.37 67 22880 10948 29918583
Pseudomembranous colitis 66.89 11.37 36 22911 2832 29926699
Clostridium difficile colitis 66.06 11.37 64 22883 12704 29916827
Acute kidney injury 59.83 11.37 386 22561 273456 29656075
Pruritus 59.21 11.37 212 22735 117992 29811539
Cellulitis 53.88 11.37 114 22833 46670 29882861
Death 53.64 11.37 122 22825 357161 29572370
Eosinophilia 50.52 11.37 73 22874 22087 29907444
Tubulointerstitial nephritis 48.39 11.37 64 22883 17827 29911704
Oesophageal ulcer 46.95 11.37 30 22917 3247 29926284
Drug eruption 44.81 11.37 61 22886 17465 29912066
Graft infection 43.38 11.37 15 22932 393 29929138
Hepatocellular injury 41.57 11.37 72 22875 25399 29904132
Dermatitis allergic 39.79 11.37 34 22913 5738 29923793
Erythema 39.66 11.37 140 22807 77311 29852220
Pyrexia 38.11 11.37 368 22579 294121 29635410
Drug abuse 36.44 11.37 9 22938 82063 29847468
Dermatitis exfoliative 36.01 11.37 36 22911 7420 29922111
Abscess of salivary gland 34.61 11.37 7 22940 17 29929514
Electrocardiogram U wave present 34.06 11.37 7 22940 19 29929512
Rash erythematous 33.46 11.37 61 22886 22391 29907140
Glomerulosclerosis 32.56 11.37 14 22933 668 29928863
Mononucleosis syndrome 31.87 11.37 8 22939 64 29929467
Urticaria 31.72 11.37 103 22844 54503 29875028
Megacolon 31.01 11.37 18 22929 1639 29927892
Surgical failure 30.94 11.37 8 22939 73 29929458
Abscess 30.30 11.37 38 22909 10040 29919491
Resorption bone increased 30.01 11.37 8 22939 83 29929448
Rash pustular 29.65 11.37 27 22920 4956 29924575
Osteomyelitis 28.67 11.37 45 22902 14636 29914895
Hidradenitis 27.90 11.37 13 22934 751 29928780
Erysipelas 27.87 11.37 25 22922 4499 29925032
Oropharyngeal blistering 27.81 11.37 9 22938 191 29929340
Rash morbilliform 26.51 11.37 19 22928 2483 29927048
Pathogen resistance 25.75 11.37 32 22915 8378 29921153
Cholestasis 25.53 11.37 58 22889 24892 29904639
Stevens-Johnson syndrome 25.28 11.37 47 22900 17509 29912022
Necrotising fasciitis 25.18 11.37 21 22926 3428 29926103
Swelling face 24.77 11.37 52 22895 21152 29908379
Venolymphatic malformation 24.73 11.37 6 22941 41 29929490
Sialoadenitis 24.53 11.37 10 22937 417 29929114
Clostridial infection 24.27 11.37 21 22926 3604 29925927
Vascular purpura 23.82 11.37 15 22932 1582 29927949
Overgrowth bacterial 23.78 11.37 7 22940 107 29929424
Rash pruritic 23.68 11.37 53 22894 22519 29907012
Completed suicide 23.41 11.37 25 22922 99467 29830064
Toxic epidermal necrolysis 23.34 11.37 46 22901 17894 29911637
Kounis syndrome 23.18 11.37 15 22932 1658 29927873
Mucormycosis 22.83 11.37 24 22923 5244 29924287
Cerebral toxoplasmosis 22.40 11.37 14 22933 1458 29928073
Milk-alkali syndrome 22.29 11.37 10 22937 529 29929002
Toxicity to various agents 22.26 11.37 66 22881 177117 29752414
Staphylococcal infection 22.25 11.37 62 22885 30162 29899369
Cerebrovascular accident 21.94 11.37 19 22928 83458 29846073
Oesophagitis ulcerative 21.72 11.37 11 22936 763 29928768
Intentional overdose 21.72 11.37 3 22944 41478 29888053
Calcium deficiency 21.53 11.37 7 22940 151 29929380
Skin graft failure 21.40 11.37 7 22940 154 29929377
Drug ineffective 21.20 11.37 372 22575 340015 29589516
Myocardial infarction 21.19 11.37 40 22907 125585 29803946
Infectious mononucleosis 20.88 11.37 9 22938 432 29929099
Rash macular 20.55 11.37 32 22915 10335 29919196
Pancytopenia 20.38 11.37 123 22824 84929 29844602
Fungal infection 20.32 11.37 37 22910 13563 29915968
Renal hypoplasia 20.30 11.37 6 22941 93 29929438
Gastrointestinal mucosa hyperaemia 20.29 11.37 7 22940 182 29929349
Liver injury 20.16 11.37 35 22912 12365 29917166
Osteomyelitis salmonella 20.15 11.37 5 22942 38 29929493
Hypersensitivity vasculitis 19.89 11.37 19 22928 3704 29925827
Methaemoglobinaemia 19.83 11.37 16 22931 2494 29927037
Antibiotic level below therapeutic 19.50 11.37 5 22942 44 29929487
Burn infection 19.16 11.37 4 22943 12 29929519
Anamnestic reaction 19.02 11.37 5 22942 49 29929482
Fatigue 19.00 11.37 156 22791 320517 29609014
Toxic shock syndrome streptococcal 18.28 11.37 4 22943 16 29929515
Foreign body 18.24 11.37 11 22936 1074 29928457
Clostridium test positive 18.17 11.37 14 22933 2042 29927489
Kidney fibrosis 17.99 11.37 14 22933 2071 29927460
Overdose 17.89 11.37 23 22924 84314 29845217
Pouchitis 17.46 11.37 9 22938 648 29928883
Rheumatoid arthritis 17.36 11.37 5 22942 41192 29888339
Purpura 17.35 11.37 29 22918 9938 29919593
Vitamin A deficiency 17.08 11.37 4 22943 23 29929508
Allergic reaction to excipient 16.66 11.37 4 22943 26 29929505
Skin infection 16.64 11.37 22 22925 6122 29923409
Atrioventricular block 16.60 11.37 24 22923 7258 29922273
Drug clearance increased 16.49 11.37 5 22942 85 29929446
Clostridium difficile infection 16.49 11.37 37 22910 15746 29913785
Brain stem infarction 16.37 11.37 11 22936 1295 29928236
Vasculitis 16.31 11.37 25 22922 7965 29921566
Agranulocytosis 16.14 11.37 45 22902 21897 29907634
Oesophagitis chemical 15.99 11.37 3 22944 4 29929527
Nephropathy toxic 15.97 11.37 29 22918 10610 29918921
Cardiac failure congestive 15.94 11.37 25 22922 84382 29845149
Headache 15.73 11.37 79 22868 182227 29747304
Fall 15.59 11.37 79 22868 181793 29747738
Vitamin B1 deficiency 15.55 11.37 6 22941 216 29929315
Cutaneous vasculitis 15.48 11.37 15 22932 2976 29926555
Urine alcohol test positive 15.42 11.37 4 22943 37 29929494
Anal ulcer 15.35 11.37 8 22939 589 29928942
Septic shock 15.24 11.37 92 22855 63515 29866016
Vertical infection transmission 15.23 11.37 3 22944 6 29929525
Erythema multiforme 14.93 11.37 24 22923 7961 29921570
Dry gangrene 14.74 11.37 6 22941 249 29929282
Medical device site joint infection 14.71 11.37 4 22943 45 29929486
Post procedural fistula 14.71 11.37 4 22943 45 29929486
Insomnia 14.63 11.37 31 22916 93305 29836226
Drug resistance 14.52 11.37 41 22906 20092 29909439
Polycystic liver disease 14.40 11.37 4 22943 49 29929482
Toxic shock syndrome 14.26 11.37 7 22940 454 29929077
Multiple organ dysfunction syndrome 14.06 11.37 90 22857 63397 29866134
Aeromonas infection 14.06 11.37 6 22941 281 29929250
Soft tissue necrosis 14.02 11.37 6 22941 283 29929248
Debridement 13.90 11.37 9 22938 996 29928535
Hepatitis cholestatic 13.83 11.37 23 22924 7849 29921682
Pulmonary function test 13.71 11.37 3 22944 12 29929519
Tremor 13.59 11.37 23 22924 75340 29854191
Proctitis 13.56 11.37 12 22935 2122 29927409
Oesophageal pain 13.53 11.37 8 22939 754 29928777
Exophthalmos 13.48 11.37 7 22940 512 29929019
Lip swelling 13.45 11.37 30 22917 12714 29916817
Peritoneal dialysis 13.43 11.37 7 22940 516 29929015
SAPHO syndrome 13.42 11.37 4 22943 64 29929467
Tooth abscess 13.34 11.37 18 22929 5108 29924423
Furuncle 13.29 11.37 14 22933 3065 29926466
Acne fulminans 13.26 11.37 5 22942 169 29929362
Leg amputation 13.24 11.37 12 22935 2189 29927342
Electrocardiogram U-wave abnormality 13.19 11.37 4 22943 68 29929463
Memory impairment 13.15 11.37 6 22941 37168 29892363
Aggression 12.98 11.37 6 22941 36901 29892630
Microangiopathic haemolytic anaemia 12.90 11.37 8 22939 821 29928710
Blood alkaline phosphatase increased 12.86 11.37 53 22894 31434 29898097
Suicide attempt 12.86 11.37 6 22941 36691 29892840
Dizziness 12.84 11.37 92 22855 194817 29734714
Arthrofibrosis 12.83 11.37 4 22943 75 29929456
Skin exfoliation 12.81 11.37 43 22904 23129 29906402
Vasculitis necrotising 12.56 11.37 7 22940 590 29928941
Malabsorption from administration site 12.54 11.37 4 22943 81 29929450
Acute respiratory distress syndrome 12.48 11.37 43 22904 23429 29906102
Tracheitis 12.34 11.37 7 22940 610 29928921
Micturition frequency decreased 12.25 11.37 5 22942 209 29929322
Magnesium deficiency 12.18 11.37 4 22943 89 29929442
Diarrhoea 12.08 11.37 338 22609 333765 29595766
Eyelid oedema 12.05 11.37 17 22930 5028 29924503
Dermatitis 11.97 11.37 22 22925 8120 29921411
Staphylococcal sepsis 11.94 11.37 24 22923 9467 29920064
Angioedema 11.85 11.37 55 22892 34329 29895202
Clostridium colitis 11.78 11.37 9 22938 1296 29928235
Metabolic alkalosis 11.66 11.37 9 22938 1315 29928216
Limb fracture 11.54 11.37 3 22944 28 29929503
Eyelid function disorder 11.54 11.37 3 22944 28 29929503
Pharyngeal oedema 11.49 11.37 19 22928 6452 29923079
Folate deficiency 11.47 11.37 8 22939 1001 29928530
Jaw fracture 11.45 11.37 8 22939 1004 29928527
International normalised ratio increased 11.40 11.37 69 22878 47670 29881861

Pharmacologic Action:

SourceCodeDescription
ATC D10AF01 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
ATC D10AF51 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
ATC G01AA10 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
ATC J01FF01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Lincosamides
FDA CS M0515779 Lincosamides
FDA PE N0000009982 Decreased Sebaceous Gland Activity
FDA EPC N0000175443 Lincosamide Antibacterial
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Anaerobic septicemia indication 1976008
Bacterial septicemia indication 10001005 DOID:0040085
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Streptococcal septicemia indication 29577008
Pneumonia due to Streptococcus indication 34020007
Empyema of pleura indication 58554001 DOID:3798
Acne vulgaris indication 88616000
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Infectious disease of abdomen indication 128070006
Pneumococcal pneumonia indication 233607000
Gas gangrene caused by clostridium perfringens indication 266093005
Streptococcus pyogenes infection indication 302809008
Infectious disorder of joint indication 363162000
Infection due to Staphylococcus aureus indication 406602003
Bacterial vaginosis indication 419760006 DOID:3385
Aspiration pneumonia indication 422588002 DOID:3240
Infection due to anaerobic bacteria indication 423451008
Osteomyelitis due to Staphylococcus aureus indication 428783003
Inflammatory Disease of Female Pelvic Organs indication
Anaerobic Joint Infection indication
Anaerobic Tubo-Ovarian Abscess indication
Prevention of Bacterial Endocarditis indication
Anaerobic Peritonitis indication
Clostridium Perfringens Empyema indication
Anaerobic Pelvic Cellulitis indication
Anaerobic Lung Abscess indication
Skin and Skin Structure Anaerobic Infection indication
Bacteroides Endomyometritis indication
Anaerobic Endometritis indication
Intra-Abdominal Anaerobic Abscess indication
Pyrexia of unknown origin off-label use 7520000
Inhalational anthrax off-label use 11389007
Actinomycotic infection off-label use 11817007 DOID:8478
Babesiosis off-label use 21061004 DOID:9643
Sinusitis off-label use 36971009
Erysipelas off-label use 44653001 DOID:11330
Malaria off-label use 61462000 DOID:12365
Acute bacterial sinusitis off-label use 75498004
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Bacterial infection of skin off-label use 128936008
Toxoplasmosis off-label use 187192000 DOID:9965
Diverticulitis of gastrointestinal tract off-label use 271366000
Infective otitis media off-label use 312218008
Rosacea off-label use 398909004 DOID:8881
Anthrax off-label use 409498004 DOID:7427
Pneumocystosis jiroveci pneumonia off-label use 415125002 DOID:11339
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Diabetic Foot Infection off-label use
Chloroquine Resistant Plasmodium Falciparum Malaria off-label use
Encephalitis due to Toxoplasmosis off-label use
Diabetic Foot Infection Due to Gram-Positive Bacteria off-label use
Gardnerella Vaginalis Bacterial Vaginosis off-label use
Sunburn contraindication 23346002
Atopic dermatitis contraindication 24079001 DOID:3310
Crohn's disease contraindication 34000006
Eczema contraindication 43116000
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Candidal vulvovaginitis contraindication 72605008 DOID:2272
Pregnancy, function contraindication 289908002
Pseudomembranous enterocolitis contraindication 397683000
Erythroderma contraindication 399992009
Breastfeeding (mother) contraindication 413712001
Inflammatory dermatosis contraindication 703938007
Bloody Stools contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.85 acidic
pKa2 13.38 acidic
pKa3 7.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
50S ribosomal protein L10 Ribosomal protein WOMBAT-PK

External reference:

IDSource
4019683 VUID
N0000147775 NUI
D00277 KEGG_DRUG
21462-39-5 SECONDARY_CAS_RN
4018082 VANDF
4019683 VANDF
C0008947 UMLSCUI
CHEBI:3745 CHEBI
CLY PDB_CHEM_ID
2786 PUBCHEM_CID
CHEMBL1753 ChEMBL_ID
CHEMBL1200588 ChEMBL_ID
DB01190 DRUGBANK_ID
D002981 MESH_DESCRIPTOR_UI
10607 IUPHAR_LIGAND_ID
2550 INN_ID
3U02EL437C UNII
2582 RXNORM
11401 MMSL
4466 MMSL
4467 MMSL
d00043 MMSL
002794 NDDF
002795 NDDF
372786004 SNOMEDCT_US
58883005 SNOMEDCT_US
63084001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0225 CAPSULE 150 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0331 CAPSULE 75 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0395 CAPSULE 300 mg ORAL NDA 27 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1381 CAPSULE 75 mg ORAL ANDA 22 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1382 CAPSULE 150 mg ORAL ANDA 22 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1383 CAPSULE 300 mg ORAL ANDA 22 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-2932 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-5708 CAPSULE 150 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0713-3171 CAPSULE 150 mg ORAL ANDA 24 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0713-5256 CAPSULE 300 mg ORAL ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3288 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3289 INJECTION, SOLUTION 12 mg INTRAVENOUS ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3290 INJECTION, SOLUTION 18 mg INTRAVENOUS ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9220 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 23 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9221 INJECTION, SOLUTION 12 mg INTRAVENOUS ANDA 23 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-9222 INJECTION, SOLUTION 18 mg INTRAVENOUS ANDA 23 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-5959 CAPSULE 150 mg ORAL ANDA 23 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-153 CAPSULE 150 mg ORAL ANDA 25 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-154 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 12634-092 CAPSULE 150 mg ORAL ANDA 24 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16590-057 CAPSULE 150 mg ORAL ANDA 13 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-033 CAPSULE 150 mg ORAL ANDA 25 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-034 CAPSULE 300 mg ORAL ANDA 25 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-159 CAPSULE 150 mg ORAL ANDA 24 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-448 CAPSULE 300 mg ORAL ANDA 24 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-532 CAPSULE 150 mg ORAL ANDA 24 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42571-250 CAPSULE 75 mg ORAL ANDA 23 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42571-251 CAPSULE 150 mg ORAL ANDA 23 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42571-252 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-394 CAPSULE 150 mg ORAL ANDA 22 sections