clindamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 678 18323-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clindamycin hydrochloride hydrate
  • clindamycin
  • 7-Chloro-7-deoxylincomycin
  • 7-Chlorolincomycin
  • 7-Deoxy-7(S)-chlorolincomycin
  • chlolincocin
  • clincin
  • clinimycin
  • Dalacin C
  • dalacine
  • clindamycin hydrochloride
  • clindamycin HCl
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
  • Molecular weight: 424.98
  • Formula: C18H33ClN2O5S
  • CLOGP: 2.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 102.26
  • ALOGS: -2.14
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g V
1.20 g O
1.80 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 13 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 70.59 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 87 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.79 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,BRAF,CAMK2D,CDK5,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1,ZAP70 21
kinase-selectivity-class CHUK,MAP2K6,PDK1 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1

Approvals:

DateAgencyCompanyOrphan
Feb. 22, 1970 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 2986.34 10.59 2319 50264 461290 90114574
Acute generalised exanthematous pustulosis 532.20 10.59 224 52359 13479 90562385
Rash maculo-papular 413.10 10.59 271 52312 40662 90535202
Hidradenitis 263.28 10.59 98 52485 4249 90571615
Toxic skin eruption 256.66 10.59 142 52441 15632 90560232
Drug reaction with eosinophilia and systemic symptoms 253.04 10.59 205 52378 42553 90533311
Rash 230.86 10.59 992 51591 795108 89780756
Loss of employment 168.75 10.59 64 52519 2923 90572941
Clostridium difficile infection 167.87 10.59 151 52432 36094 90539770
Synovitis 164.88 10.59 6 52577 329746 90246118
Type IV hypersensitivity reaction 161.88 10.59 67 52516 3859 90572005
Pemphigus 156.64 10.59 8 52575 326856 90249008
Glossodynia 150.71 10.59 9 52574 321770 90254094
Systemic lupus erythematosus 136.44 10.59 23 52560 361873 90213991
Hand deformity 128.25 10.59 12 52571 296350 90279514
Clostridium difficile colitis 123.14 10.59 111 52472 26595 90549269
Dermatitis allergic 119.59 10.59 91 52492 17236 90558628
Anti-cyclic citrullinated peptide antibody positive 119.21 10.59 4 52579 236429 90339435
Eosinophilia 116.86 10.59 111 52472 28422 90547442
Erythema 116.31 10.59 344 52239 228902 90346962
Toxic epidermal necrolysis 115.43 10.59 117 52466 32411 90543453
Helicobacter infection 113.80 10.59 4 52579 226846 90349018
Hepatic steatosis 106.50 10.59 119 52464 36826 90539038
Pericarditis 104.42 10.59 16 52567 270135 90305729
Multiple organ dysfunction syndrome 104.41 10.59 161 52422 68175 90507689
Drug resistance 103.47 10.59 107 52476 30342 90545522
Acute kidney injury 100.68 10.59 410 52173 319977 90255887
Drug ineffective 99.16 10.59 1230 51353 1383068 89192796
Joint swelling 97.66 10.59 89 52494 503211 90072653
Anaphylactic reaction 97.45 10.59 179 52404 87345 90488519
Symmetrical drug-related intertriginous and flexural exanthema 93.56 10.59 31 52552 948 90574916
Cellulitis 90.81 10.59 178 52405 91159 90484705
Infusion related reaction 90.41 10.59 66 52517 416714 90159150
Fibromyalgia 90.15 10.59 8 52575 206261 90369603
Alopecia 88.60 10.59 94 52489 494977 90080887
Arthropathy 84.76 10.59 54 52529 366188 90209676
Wound 84.49 10.59 35 52548 302945 90272919
Folliculitis 83.95 10.59 10 52573 204343 90371521
Urticaria 81.98 10.59 379 52204 312355 90263509
Pruritus 81.94 10.59 566 52017 540959 90034905
Abscess 80.24 10.59 75 52508 18816 90557048
Abortion spontaneous 79.28 10.59 125 52458 53931 90521933
Rheumatoid arthritis 72.85 10.59 62 52521 362552 90213312
Type 2 diabetes mellitus 72.09 10.59 15 52568 203229 90372635
Discomfort 69.80 10.59 36 52547 274299 90301565
Blood cholesterol increased 68.54 10.59 18 52565 207994 90367870
Irritable bowel syndrome 68.26 10.59 18 52565 207430 90368434
Pathogen resistance 68.18 10.59 48 52535 8067 90567797
Drug eruption 62.07 10.59 89 52494 35318 90540546
Subcutaneous abscess 62.05 10.59 42 52541 6624 90569240
Graft infection 61.87 10.59 17 52566 269 90575595
Acne 59.55 10.59 78 52505 28429 90547435
Ill-defined disorder 59.04 10.59 17 52566 184874 90390990
Stomatitis 58.88 10.59 44 52539 274654 90301210
Pustule 58.28 10.59 30 52553 2853 90573011
Pseudomembranous colitis 57.96 10.59 33 52550 3835 90572029
Confusional state 57.85 10.59 84 52499 386121 90189743
Oesophagitis 57.49 10.59 60 52523 17189 90558675
Premature delivery 57.34 10.59 90 52493 38672 90537192
Septic shock 56.37 10.59 140 52443 84020 90491844
Lower respiratory tract infection 55.21 10.59 39 52544 250620 90325244
Musculoskeletal stiffness 52.21 10.59 57 52526 296475 90279389
Diarrhoea 51.18 10.59 796 51787 938394 89637470
Psoriatic arthropathy 50.98 10.59 35 52548 228300 90347564
Tubulointerstitial nephritis 50.87 10.59 68 52515 25275 90550589
Staphylococcal infection 50.08 10.59 96 52487 48343 90527521
Mobility decreased 48.96 10.59 44 52539 250690 90325174
Peripheral swelling 47.37 10.59 106 52477 413000 90162864
Leukocytosis 47.30 10.59 73 52510 30917 90544947
Papule 46.54 10.59 38 52545 7964 90567900
Product use in unapproved indication 46.42 10.59 344 52239 335892 90239972
Rash morbilliform 46.37 10.59 29 52554 4000 90571864
Stevens-Johnson syndrome 45.96 10.59 70 52513 29306 90546558
Hepatic enzyme increased 45.20 10.59 88 52495 360648 90215216
Skin lesion 44.87 10.59 79 52504 37286 90538578
Pulmonary fibrosis 44.79 10.59 5 52578 107498 90468366
Sinobronchitis 43.16 10.59 16 52567 685 90575179
Death 42.53 10.59 130 52453 456421 90119443
Facet joint syndrome 42.48 10.59 4 52579 98385 90477479
Cardiac failure congestive 41.60 10.59 139 52444 98555 90477309
Skin exfoliation 41.36 10.59 109 52474 67804 90508060
Osteonecrosis of jaw 41.04 10.59 78 52505 39025 90536839
Type I hypersensitivity 40.65 10.59 27 52556 4128 90571736
Bartholinitis 40.04 10.59 9 52574 58 90575806
Eczema 39.76 10.59 92 52491 52778 90523086
Wound complication 39.61 10.59 28 52555 4735 90571129
Sleep disorder 39.56 10.59 34 52549 197996 90377868
Gastric disorder 39.33 10.59 70 52513 33314 90542550
Lip dry 38.93 10.59 6 52577 100949 90474915
Osteomyelitis 38.91 10.59 63 52520 27783 90548081
Hypercholesterolaemia 38.90 10.59 6 52577 100886 90474978
Cyst 38.83 10.59 48 52535 16513 90559351
Drug ineffective for unapproved indication 38.60 10.59 105 52478 66539 90509325
Hepatitis infectious mononucleosis 38.36 10.59 10 52573 128 90575736
Tubo-ovarian abscess 38.24 10.59 13 52570 431 90575433
Decreased appetite 38.15 10.59 103 52480 376437 90199427
Night sweats 37.30 10.59 14 52569 128752 90447112
Face oedema 37.09 10.59 56 52527 23262 90552602
Red blood cell sedimentation rate increased 36.63 10.59 3 52580 82592 90493272
Klebsiella infection 36.45 10.59 37 52546 10260 90565604
Gait inability 36.08 10.59 20 52563 146436 90429428
Necrotising oesophagitis 35.68 10.59 13 52570 530 90575334
Fatigue 35.43 10.59 465 52118 1153558 89422306
Idiosyncratic drug reaction 34.79 10.59 15 52568 956 90574908
Osteoarthritis 34.02 10.59 38 52545 195692 90380172
Impaired healing 34.00 10.59 52 52531 234147 90341717
Toxic shock syndrome 33.75 10.59 15 52568 1029 90574835
Dermatitis 33.43 10.59 52 52531 22168 90553696
Pneumonia 33.37 10.59 225 52358 637834 89938030
Central pain syndrome 33.02 10.59 13 52570 657 90575207
Dysbiosis 32.37 10.59 17 52566 1685 90574179
Rash erythematous 32.29 10.59 97 52486 65007 90510857
Weight increased 31.56 10.59 130 52453 417797 90158067
Oesophageal ulcer 31.23 10.59 25 52558 5094 90570770
Contraindicated product administered 30.62 10.59 90 52493 320049 90255815
Toxic shock syndrome streptococcal 30.49 10.59 10 52573 296 90575568
Hepatic cytolysis 30.40 10.59 60 52523 30856 90545008
General physical health deterioration 30.36 10.59 105 52478 355010 90220854
Joint range of motion decreased 29.99 10.59 21 52562 135622 90440242
Candida infection 29.83 10.59 63 52520 33994 90541870
Intentional product use issue 29.75 10.59 50 52533 216842 90359022
Bursitis 29.62 10.59 20 52563 131634 90444230
Epilepsy 29.27 10.59 6 52577 82200 90493664
Reaction to azo-dyes 29.07 10.59 6 52577 24 90575840
Adverse event 28.97 10.59 16 52567 117402 90458462
Scar 28.91 10.59 40 52543 15355 90560509
Lower limb fracture 28.67 10.59 7 52576 85006 90490858
Pyrexia 28.66 10.59 540 52043 659945 89915919
Fistula 28.28 10.59 35 52548 12054 90563810
Pneumococcal infection 28.22 10.59 14 52569 1231 90574633
Cholestasis 28.21 10.59 64 52519 36235 90539629
Peripheral venous disease 28.13 10.59 7 52576 83914 90491950
Abscess neck 28.07 10.59 12 52571 749 90575115
Upper respiratory tract infection bacterial 27.75 10.59 8 52575 152 90575712
Lymphadenopathy 27.39 10.59 73 52510 45702 90530162
Micrococcus infection 27.26 10.59 7 52576 84 90575780
Blister 26.38 10.59 69 52514 254929 90320935
Allergic sinusitis 26.33 10.59 16 52567 2097 90573767
Autoimmune thyroiditis 26.19 10.59 24 52559 5869 90569995
Prescribed overdose 26.04 10.59 12 52571 97613 90478251
Asthenia 26.03 10.59 192 52391 533559 90042305
Swelling of eyelid 25.79 10.59 23 52560 5431 90570433
Skin odour abnormal 25.75 10.59 15 52568 1820 90574044
Purpura 25.68 10.59 37 52546 14741 90561123
Prescribed underdose 25.65 10.59 6 52577 75013 90500851
Fungal sepsis 25.41 10.59 14 52569 1527 90574337
Musculoskeletal pain 24.87 10.59 38 52545 171213 90404651
Swelling 24.87 10.59 142 52441 418916 90156948
Clostridial infection 24.85 10.59 21 52562 4615 90571249
Sciatica 24.75 10.59 14 52569 101368 90474496
Toxicity to various agents 24.67 10.59 85 52498 287761 90288103
Dermatitis acneiform 24.65 10.59 24 52559 6330 90569534
Autoimmune disorder 24.59 10.59 7 52576 76737 90499127
Acne pustular 24.42 10.59 8 52575 236 90575628
Escherichia infection 23.63 10.59 37 52546 15858 90560006
Road traffic accident 23.35 10.59 17 52566 107609 90468255
Swelling face 23.06 10.59 101 52482 81251 90494613
Hypoaesthesia 22.93 10.59 99 52484 314111 90261753
Tendinous contracture 22.85 10.59 7 52576 165 90575699
Type IIb hyperlipidaemia 22.55 10.59 5 52578 30 90575834
Hip arthroplasty 22.55 10.59 8 52575 76200 90499664
Skin disorder 22.43 10.59 59 52524 36647 90539217
Tooth hypoplasia 22.32 10.59 6 52577 87 90575777
Sepsis syndrome 22.23 10.59 11 52572 962 90574902
Cutaneous vasculitis 22.16 10.59 24 52559 7169 90568695
Clostridium test positive 22.09 10.59 21 52562 5380 90570484
Cough 22.02 10.59 318 52265 368644 90207220
Shock haemorrhagic 21.78 10.59 31 52552 12214 90563650
Coagulation factor decreased 21.71 10.59 7 52576 196 90575668
Puerperal pyrexia 21.64 10.59 5 52578 37 90575827
Memory impairment 21.46 10.59 52 52531 197192 90378672
Anti factor V antibody positive 21.42 10.59 4 52579 8 90575856
Mastitis 21.27 10.59 16 52567 2977 90572887
Completed suicide 21.24 10.59 32 52551 145026 90430838
Acute hepatic failure 21.24 10.59 43 52540 22518 90553346
Glomerulonephritis minimal lesion 21.12 10.59 8 52575 364 90575500
Hypoglossal nerve paresis 20.86 10.59 6 52577 113 90575751
Wheezing 20.60 10.59 70 52513 238010 90337854
Lip swelling 20.55 10.59 59 52524 38551 90537313
Respiratory gas exchange disorder 20.38 10.59 8 52575 401 90575463
Iodine allergy 20.20 10.59 10 52573 876 90574988
Aspergillus infection 20.14 10.59 28 52555 10795 90565069
Blood testosterone increased 20.09 10.59 7 52576 250 90575614
Rash macular 19.87 10.59 50 52533 30230 90545634
Mucormycosis 19.85 10.59 17 52566 3804 90572060
Haemodynamic instability 19.83 10.59 29 52554 11710 90564154
Skin mass 19.82 10.59 23 52560 7407 90568457
Wound secretion 19.64 10.59 19 52564 4971 90570893
Oedema 19.36 10.59 56 52527 200239 90375625
Product contamination microbial 19.36 10.59 7 52576 279 90575585
Surgical failure 19.25 10.59 10 52573 969 90574895
Live birth 19.20 10.59 11 52572 79096 90496768
Post infection glomerulonephritis 19.19 10.59 4 52579 17 90575847
Bronchial obstruction 19.04 10.59 12 52571 1677 90574187
Contusion 19.03 10.59 78 52505 251138 90324726
Gas gangrene 18.92 10.59 6 52577 159 90575705
Intentional overdose 18.86 10.59 16 52567 93818 90482046
C-reactive protein increased 18.82 10.59 49 52534 181340 90394524
Lower respiratory tract infection bacterial 18.72 10.59 8 52575 499 90575365
Acarodermatitis 18.58 10.59 11 52572 1375 90574489
Adjustment disorder with depressed mood 18.51 10.59 5 52578 56748 90519116
Sinus pain 18.41 10.59 19 52564 5370 90570494
Nephritis allergic 18.39 10.59 7 52576 323 90575541
Megacolon 18.38 10.59 13 52570 2201 90573663
Serratia infection 18.28 10.59 10 52573 1075 90574789
Insomnia 18.20 10.59 116 52467 333358 90242506
Renal arteriosclerosis 18.19 10.59 6 52577 181 90575683
Oxygen saturation abnormal 18.16 10.59 17 52566 4271 90571593
Erosive oesophagitis 18.16 10.59 12 52571 1819 90574045
Wound infection 18.11 10.59 21 52562 106381 90469483
Thyroxine increased 18.02 10.59 9 52574 803 90575061
Hypoglycaemia 17.99 10.59 9 52574 69839 90506025
Oxygen saturation increased 17.83 10.59 7 52576 351 90575513
Renal tubular necrosis 17.76 10.59 31 52552 14524 90561340
Syndactyly 17.49 10.59 8 52575 587 90575277
Pneumothorax 17.42 10.59 36 52547 19131 90556733
Skin plaque 17.37 10.59 25 52558 9950 90565914
Pseudomonas infection 17.29 10.59 31 52552 14834 90561030
Chest crushing 17.28 10.59 3 52580 3 90575861
Geotrichum infection 17.23 10.59 8 52575 608 90575256
Underdose 17.17 10.59 5 52578 54012 90521852
Acinetobacter infection 17.15 10.59 12 52571 1996 90573868
Onychomadesis 17.14 10.59 3 52580 45995 90529869
Abdominal wall disorder 17.07 10.59 6 52577 220 90575644
Pneumomediastinum 17.03 10.59 12 52571 2019 90573845
Fungal infection 17.01 10.59 59 52524 42602 90533262
Drug intolerance 16.90 10.59 172 52411 447419 90128445
Lymphadenitis 16.75 10.59 16 52567 4121 90571743
Antibiotic level below therapeutic 16.72 10.59 4 52579 35 90575829
Upper limb fracture 16.72 10.59 38 52545 21540 90554324
Torticollis 16.70 10.59 13 52570 2545 90573319
Dry mouth 16.69 10.59 53 52530 184006 90391858
Emotional distress 16.67 10.59 53 52530 36609 90539255
Disseminated mucormycosis 16.57 10.59 8 52575 663 90575201
Anaphylactic shock 16.52 10.59 48 52535 31569 90544295
Staphylococcal bacteraemia 16.48 10.59 21 52562 7448 90568416
Coeliac disease 16.42 10.59 3 52580 44607 90531257
Seborrhoeic dermatitis 16.40 10.59 11 52572 1709 90574155
Tinea capitis 16.33 10.59 4 52579 39 90575825
Prothrombin time prolonged 16.30 10.59 24 52559 9748 90566116
Vascular purpura 16.29 10.59 11 52572 1727 90574137
Vulval abscess 16.16 10.59 9 52574 1003 90574861
Mycobacterial infection 16.12 10.59 12 52571 2198 90573666
Documented hypersensitivity to administered product 16.10 10.59 8 52575 706 90575158
Autoimmune neutropenia 16.03 10.59 6 52577 264 90575600
Drug interaction 15.98 10.59 237 52346 276216 90299648
Astigmatism 15.83 10.59 10 52573 1404 90574460
Knee arthroplasty 15.74 10.59 15 52568 83167 90492697
Necrotising fasciitis 15.70 10.59 15 52568 3865 90571999
Cleft lip and palate 15.67 10.59 8 52575 748 90575116
SAPHO syndrome 15.65 10.59 5 52578 136 90575728
Axillary pain 15.60 10.59 12 52571 2309 90573555
Liver injury 15.54 10.59 49 52534 170518 90405346
Anterior segment ischaemia 15.22 10.59 4 52579 53 90575811
Lip oedema 15.21 10.59 16 52567 4623 90571241
Venous haemorrhage 15.21 10.59 6 52577 305 90575559
Perihepatic discomfort 15.21 10.59 3 52580 9 90575855
Crystal nephropathy 15.08 10.59 9 52574 1142 90574722
Angioedema 15.06 10.59 76 52507 64800 90511064
Gait disturbance 15.05 10.59 89 52494 260407 90315457
Scedosporium infection 15 10.59 8 52575 818 90575046
BK polyomavirus test positive 14.90 10.59 5 52578 159 90575705
Amnesia 14.88 10.59 25 52558 108480 90467384
Joint stiffness 14.86 10.59 14 52569 78028 90497836
Erythema multiforme 14.84 10.59 26 52557 12220 90563644
Idiopathic intracranial hypertension 14.79 10.59 14 52569 3567 90572297
Coagulation factor deficiency 14.76 10.59 4 52579 60 90575804
Skin reaction 14.74 10.59 33 52550 18520 90557344
Nasopharyngitis 14.73 10.59 158 52425 406946 90168918
Factor V inhibition 14.70 10.59 5 52578 166 90575698
Adenoidal disorder 14.64 10.59 5 52578 168 90575696
Groin abscess 14.56 10.59 9 52574 1216 90574648
Congenital lymphoedema 14.54 10.59 3 52580 12 90575852
Neonatal respiratory distress syndrome 14.51 10.59 13 52570 3088 90572776
Serum sickness-like reaction 14.49 10.59 7 52576 581 90575283
Plasmapheresis 14.47 10.59 6 52577 347 90575517
Preterm premature rupture of membranes 14.47 10.59 10 52573 1631 90574233
Hyperleukocytosis 14.47 10.59 8 52575 879 90574985
Breast abscess 14.42 10.59 11 52572 2089 90573775
Allergy to animal 14.40 10.59 10 52573 1644 90574220
Shock 14.38 10.59 43 52540 28735 90547129
Neoplasm progression 14.36 10.59 4 52579 44482 90531382
Delirium 14.35 10.59 24 52559 104335 90471529
Product deposit 14.24 10.59 6 52577 361 90575503
Paraesthesia 14.21 10.59 86 52497 250240 90325624
Liver function test increased 14.17 10.59 17 52566 84838 90491026
Acne fulminans 14.16 10.59 3 52580 14 90575850
Bronchopulmonary dysplasia 14.10 10.59 7 52576 617 90575247
Disease recurrence 14.09 10.59 51 52532 37602 90538262
Medication error 14.09 10.59 17 52566 84635 90491229
Dizziness 14.04 10.59 249 52334 589035 89986829
Joint vibration 13.99 10.59 3 52580 15 90575849
Product physical consistency issue 13.92 10.59 8 52575 946 90574918
Coma 13.86 10.59 13 52570 72619 90503245
Pneumonia necrotising 13.86 10.59 7 52576 640 90575224
Tinea infection 13.84 10.59 9 52574 1327 90574537
Hepatic cirrhosis 13.71 10.59 10 52573 63243 90512621
Frequent bowel movements 13.70 10.59 8 52575 56927 90518937
Sphingomonas paucimobilis infection 13.68 10.59 4 52579 80 90575784
Necrosis 13.67 10.59 18 52565 6592 90569272
Exophthalmos 13.63 10.59 10 52573 1792 90574072
Congenital hydrocephalus 13.53 10.59 5 52578 212 90575652
Acute respiratory distress syndrome 13.53 10.59 42 52541 28644 90547220
Hepatorenal failure 13.36 10.59 7 52576 690 90575174
Thermal burn 13.35 10.59 18 52565 6744 90569120
Allergy to metals 13.28 10.59 8 52575 1032 90574832
Purulent discharge 13.21 10.59 16 52567 5389 90570475
Condition aggravated 13.21 10.59 445 52138 595100 89980764
Product administration interrupted 13.21 10.59 25 52558 12467 90563397
Sexual inhibition 13.01 10.59 3 52580 22 90575842
Bullous haemorrhagic dermatosis 13.00 10.59 5 52578 237 90575627
Abscess jaw 13 10.59 9 52574 1472 90574392
Chills 12.85 10.59 125 52458 131856 90444008
Retinal degeneration 12.81 10.59 8 52575 1101 90574763
Adenovirus reactivation 12.79 10.59 5 52578 248 90575616
Sedation 12.72 10.59 6 52577 48165 90527699
Culture positive 12.66 10.59 6 52577 477 90575387
Treatment failure 12.65 10.59 114 52469 303814 90272050
Blood pressure diastolic increased 12.63 10.59 25 52558 12881 90562983
Dysarthria 12.62 10.59 8 52575 54474 90521390
Nodule 12.52 10.59 39 52544 26647 90549217
Skin oedema 12.52 10.59 8 52575 1146 90574718
Chronic kidney disease 12.50 10.59 60 52523 50131 90525733
Hypervigilance 12.49 10.59 6 52577 492 90575372
Spinal muscular atrophy 12.47 10.59 3 52580 27 90575837
Night blindness 12.41 10.59 6 52577 499 90575365
Lemierre syndrome 12.37 10.59 4 52579 113 90575751
Headache 12.36 10.59 394 52189 862352 89713512
Rash pustular 12.33 10.59 19 52564 8030 90567834
Cardiac failure 12.33 10.59 107 52476 109389 90466475
Adenocarcinoma 12.26 10.59 12 52571 3184 90572680
Glomerulosclerosis 12.24 10.59 6 52577 514 90575350
Pyoderma gangrenosum 12.22 10.59 14 52569 4450 90571414
Infected skin ulcer 12.21 10.59 11 52572 2631 90573233
Babesiosis 12.21 10.59 5 52578 280 90575584
Injury 12.16 10.59 66 52517 197283 90378581
Tooth extraction 12.12 10.59 23 52560 11490 90564374
Weaning failure 12.09 10.59 6 52577 528 90575336
Cholecystitis chronic 12.08 10.59 21 52562 9805 90566059
Dry skin 12.06 10.59 90 52493 87983 90487881
Vulvovaginal discomfort 12.02 10.59 11 52572 2686 90573178
Chronic respiratory disease 11.95 10.59 5 52578 296 90575568
Agranulocytosis 11.93 10.59 46 52537 34956 90540908
Infection protozoal 11.92 10.59 3 52580 33 90575831
Overdose 11.92 10.59 49 52534 157660 90418204
Pyoderma 11.91 10.59 6 52577 545 90575319
Pharyngeal swelling 11.90 10.59 21 52562 9923 90565941
Tooth infection 11.90 10.59 32 52551 20138 90555726
Haemolytic anaemia 11.86 10.59 23 52560 11674 90564190
Walking aid user 11.82 10.59 3 52580 35503 90540361
Bradycardia 11.79 10.59 19 52564 83828 90492036
Abdominal wall haematoma 11.78 10.59 12 52571 3340 90572524
Muscle spasticity 11.73 10.59 3 52580 35319 90540545
Oesophageal discomfort 11.71 10.59 5 52578 311 90575553
Nausea 11.70 10.59 770 51813 1109546 89466318
Paranasal sinus abscess 11.67 10.59 4 52579 136 90575728
Lupus-like syndrome 11.56 10.59 7 52576 48839 90527025
Injection site erythema 11.49 10.59 25 52558 98477 90477387
X-ray abnormal 11.48 10.59 6 52577 45418 90530446
Bile output increased 11.46 10.59 3 52580 39 90575825
Viral uveitis 11.32 10.59 4 52579 149 90575715
Premature rupture of membranes 11.28 10.59 15 52568 5543 90570321
Eczema asteatotic 11.24 10.59 5 52578 344 90575520
Cerebral toxoplasmosis 11.09 10.59 8 52575 1397 90574467
Perfume sensitivity 11.05 10.59 7 52576 988 90574876
Fall 11.02 10.59 205 52378 481605 90094259
Hyphaema 11.01 10.59 5 52578 361 90575503
Rectocele repair 11.01 10.59 3 52580 46 90575818
Scab 10.96 10.59 20 52563 9701 90566163
Neurodermatitis 10.91 10.59 11 52572 3027 90572837
Superinfection bacterial 10.87 10.59 7 52576 1015 90574849
Abdominal sepsis 10.82 10.59 8 52575 1451 90574413
Illness 10.79 10.59 83 52500 81886 90493978
Exostosis 10.75 10.59 9 52574 53125 90522739
Bone erosion 10.71 10.59 9 52574 53012 90522852
White matter lesion 10.69 10.59 10 52573 2511 90573353
Erysipelas 10.69 10.59 19 52564 9033 90566831
Injury corneal 10.62 10.59 4 52579 179 90575685
Eye discharge 10.62 10.59 18 52565 8240 90567624
Bacterial colitis 10.60 10.59 4 52579 180 90575684

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 599.35 11.70 516 28764 98873 42493182
Rash maculo-papular 381.74 11.70 266 29014 37237 42554818
Drug reaction with eosinophilia and systemic symptoms 280.81 11.70 232 29048 41843 42550212
Acute generalised exanthematous pustulosis 256.62 11.70 123 29157 8472 42583583
Type IV hypersensitivity reaction 219.57 11.70 77 29203 2360 42589695
Drug ineffective 203.66 11.70 911 28369 629286 41962769
Rash 198.02 11.70 523 28757 276431 42315624
Clostridium difficile colitis 114.93 11.70 104 29176 21148 42570907
Toxic skin eruption 92.09 11.70 76 29204 13654 42578401
Death 85.33 11.70 120 29160 471065 42120990
Drug resistance 69.78 11.70 101 29179 34147 42557908
Pseudomembranous colitis 67.58 11.70 36 29244 3097 42588958
Hyper IgE syndrome 62.11 11.70 16 29264 162 42591893
Pruritus 61.76 11.70 275 29005 188496 42403559
Drug eruption 59.04 11.70 76 29204 22999 42569056
Erythema 58.54 11.70 186 29094 108607 42483448
Hidradenitis 58.36 11.70 27 29253 1714 42590341
Rash morbilliform 58.14 11.70 36 29244 4117 42587938
Cholestasis 57.08 11.70 90 29190 32789 42559266
Rash erythematous 54.55 11.70 87 29193 32004 42560051
Hepatocellular injury 54.43 11.70 74 29206 23604 42568451
Kounis syndrome 54.39 11.70 32 29248 3336 42588719
Drug ineffective for unapproved indication 52.51 11.70 105 29175 46058 42545997
Cutaneous vasculitis 52.43 11.70 41 29239 6819 42585236
Methaemoglobinaemia 49.61 11.70 37 29243 5737 42586318
Eosinophilia 48.94 11.70 84 29196 32815 42559240
Oesophageal ulcer 48.64 11.70 31 29249 3728 42588327
Pathogen resistance 48.53 11.70 49 29231 11401 42580654
Vascular purpura 46.82 11.70 25 29255 2161 42589894
Tubulointerstitial nephritis 46.21 11.70 80 29200 31468 42560587
Drug-induced liver injury 45.88 11.70 89 29191 38184 42553871
Acute kidney injury 44.76 11.70 416 28864 366921 42225134
Graft infection 43.41 11.70 15 29265 439 42591616
Necrotising fasciitis 43.29 11.70 31 29249 4515 42587540
Staphylococcal infection 43.26 11.70 86 29194 37557 42554498
Abscess 43.00 11.70 51 29229 14197 42577858
Toxic epidermal necrolysis 42.04 11.70 70 29210 26680 42565375
Megacolon 37.66 11.70 22 29258 2263 42589792
Dermatitis allergic 37.23 11.70 37 29243 8446 42583609
Hepatitis cholestatic 36.18 11.70 39 29241 9785 42582270
Fatigue 35.75 11.70 166 29114 435475 42156580
Purpura 34.99 11.70 42 29238 11837 42580218
Burn oesophageal 34.95 11.70 9 29271 91 42591964
Urticaria 34.82 11.70 121 29159 73915 42518140
Electrocardiogram U wave present 34.30 11.70 7 29273 21 42592034
Drug abuse 33.51 11.70 15 29265 104756 42487299
Cellulitis 32.82 11.70 105 29175 61480 42530575
Condition aggravated 31.52 11.70 295 28985 260459 42331596
Urinary tract inflammation 30.90 11.70 10 29270 238 42591817
Scar 30.90 11.70 30 29250 6658 42585397
Stevens-Johnson syndrome 30.87 11.70 55 29225 22123 42569932
Abscess of salivary gland 30.80 11.70 6 29274 13 42592042
Acne fulminans 29.23 11.70 10 29270 284 42591771
Rash pustular 28.94 11.70 28 29252 6187 42585868
Urine alcohol test positive 28.76 11.70 7 29273 55 42592000
Hypersensitivity vasculitis 28.34 11.70 21 29259 3223 42588832
Scrotal infection 28.03 11.70 13 29267 830 42591225
Surgical failure 27.75 11.70 8 29272 127 42591928
Glomerulosclerosis 27.58 11.70 13 29267 861 42591194
Rash pruritic 27.51 11.70 67 29213 33536 42558519
Venolymphatic malformation 27.32 11.70 6 29274 28 42592027
Hepatic cytolysis 26.93 11.70 58 29222 26786 42565269
Erysipelas 26.78 11.70 27 29253 6269 42585786
Skin graft failure 26.26 11.70 8 29272 155 42591900
Pyrexia 26.00 11.70 397 28883 393645 42198410
Cholestatic liver injury 25.85 11.70 21 29259 3688 42588367
Treatment failure 25.75 11.70 98 29182 62526 42529529
Resorption bone increased 25.02 11.70 9 29271 297 42591758
Perineal infection 24.66 11.70 11 29269 641 42591414
Optic nerve operation 24.21 11.70 10 29270 482 42591573
Toxicity to various agents 24.05 11.70 79 29201 229057 42362998
Agranulocytosis 23.96 11.70 60 29220 30552 42561503
Pustule 23.90 11.70 13 29267 1166 42590889
Aeromonas infection 23.60 11.70 9 29271 351 42591704
Tooth injury 23.18 11.70 13 29267 1238 42590817
Mononucleosis syndrome 22.96 11.70 7 29273 136 42591919
Pneumonia staphylococcal 22.80 11.70 19 29261 3457 42588598
Overgrowth bacterial 22.63 11.70 7 29273 143 42591912
Dermal cyst 22.21 11.70 15 29265 1988 42590067
Osteomyelitis salmonella 21.43 11.70 5 29275 32 42592023
Arteriovenous fistula 21.42 11.70 12 29268 1140 42590915
General physical health deterioration 21.31 11.70 45 29235 151201 42440854
Infected dermal cyst 20.91 11.70 11 29269 922 42591133
Somnolence 20.71 11.70 41 29239 141064 42450991
Acne conglobata 20.69 11.70 5 29275 38 42592017
Mucormycosis 20.62 11.70 25 29255 7118 42584937
Swelling face 20.52 11.70 53 29227 27501 42564554
Conductive deafness 20.45 11.70 9 29271 508 42591547
Renal hypoplasia 20.27 11.70 6 29274 105 42591950
Tremor 20.26 11.70 22 29258 96907 42495148
Torsade de pointes 19.96 11.70 27 29253 8567 42583488
Overdose 19.76 11.70 26 29254 105238 42486817
Pneumatosis intestinalis 19.52 11.70 20 29260 4732 42587323
Papule 19.50 11.70 22 29258 5804 42586251
Malaise 19.06 11.70 78 29202 212078 42379977
Dermatitis acneiform 19.02 11.70 25 29255 7714 42584341
Cerebellar microhaemorrhage 18.85 11.70 3 29277 0 42592055
Premature baby 18.77 11.70 46 29234 23107 42568948
Intentional overdose 18.72 11.70 6 29274 51450 42540605
SAPHO syndrome 18.71 11.70 8 29272 421 42591634
Prostate cancer 18.53 11.70 4 29276 44639 42547416
Vestibular disorder 18.52 11.70 11 29269 1166 42590889
Asthenia 18.52 11.70 115 29165 280678 42311377
Subcutaneous abscess 18.50 11.70 19 29261 4509 42587546
Anamnestic reaction 18.41 11.70 5 29275 63 42591992
Calcium deficiency 18.40 11.70 7 29273 271 42591784
Cardiac failure congestive 18.37 11.70 19 29261 85583 42506472
Skin candida 18.34 11.70 9 29271 652 42591403
Acute febrile neutrophilic dermatosis 18.29 11.70 13 29267 1871 42590184
Coma 18.19 11.70 7 29273 53547 42538508
Leukocytosis 18.01 11.70 53 29227 29655 42562400
Pulmonary venous thrombosis 17.93 11.70 6 29274 159 42591896
Oesophagitis ulcerative 17.90 11.70 10 29270 945 42591110
Antibiotic level below therapeutic 17.73 11.70 5 29275 73 42591982
Skin plaque 17.71 11.70 21 29259 5842 42586213
Tendon pain 17.54 11.70 16 29264 3284 42588771
Infectious mononucleosis 17.50 11.70 9 29271 720 42591335
Myocardial infarction 17.37 11.70 37 29243 123972 42468083
Device toxicity 17.37 11.70 4 29276 24 42592031
Eosinophilic pneumonia 17.34 11.70 19 29261 4855 42587200
Clostridium test positive 17.10 11.70 20 29260 5485 42586570
Completed suicide 16.93 11.70 25 29255 96440 42495615
Osteomyelitis 16.72 11.70 38 29242 18185 42573870
Septic shock 16.67 11.70 114 29166 91558 42500497
Gastrointestinal mucosa hyperaemia 16.54 11.70 7 29273 359 42591696
Toxic shock syndrome streptococcal 16.48 11.70 4 29276 31 42592024
Genital rash 16.38 11.70 9 29271 823 42591232
Cerebrovascular accident 16.26 11.70 26 29254 97134 42494921
Neutrophil count decreased 16.11 11.70 12 29268 63403 42528652
Lymphadenopathy 16.08 11.70 55 29225 33310 42558745
COVID-19 15.91 11.70 35 29245 115913 42476142
Cardiac failure 15.72 11.70 31 29249 106825 42485230
Vitamin B1 deficiency 15.64 11.70 7 29273 411 42591644
Fistula 15.62 11.70 23 29257 7889 42584166
Pouchitis 15.28 11.70 9 29271 940 42591115
Macule 15.20 11.70 12 29268 2023 42590032
Insomnia 15.17 11.70 37 29243 118216 42473839
Proctitis 15.16 11.70 14 29266 2919 42589136
Toxic shock syndrome 15.06 11.70 7 29273 449 42591606
Dermatitis atopic 15.05 11.70 29 29251 12375 42579680
Drug clearance increased 15.03 11.70 5 29275 130 42591925
Blood alkaline phosphatase increased 15.00 11.70 54 29226 33543 42558512
Vitamin A deficiency 14.83 11.70 4 29276 49 42592006
Biopsy liver 14.83 11.70 6 29274 274 42591781
Gastroenteritis yersinia 14.70 11.70 3 29277 9 42592046
Electrocardiogram U-wave abnormality 14.69 11.70 4 29276 51 42592004
Immune thrombocytopenia 14.57 11.70 27 29253 11189 42580866
Candida infection 14.50 11.70 40 29240 21570 42570485
Intracranial aneurysm 14.46 11.70 11 29269 1757 42590298
Oesophagitis chemical 14.34 11.70 4 29276 56 42591999
Face oedema 14.25 11.70 30 29250 13636 42578419
Suicide attempt 14.11 11.70 7 29273 46093 42545962
Productive cough 14.11 11.70 9 29271 51558 42540497
Diarrhoea 14.09 11.70 415 28865 460434 42131621
Kidney fibrosis 14.08 11.70 13 29267 2709 42589346
Pulmonary function test 14.03 11.70 3 29277 12 42592043
Foreign body aspiration 14.02 11.70 6 29274 316 42591739
Arthrofibrosis 13.97 11.70 4 29276 62 42591993
Acute respiratory distress syndrome 13.96 11.70 49 29231 30059 42561996
Vanishing bile duct syndrome 13.90 11.70 11 29269 1860 42590195
Thrombosis 13.82 11.70 16 29264 68495 42523560
Product use in unapproved indication 13.75 11.70 190 29090 184266 42407789
Platelet count decreased 13.69 11.70 49 29231 138532 42453523
Tinea manuum 13.49 11.70 3 29277 15 42592040
Vertical infection transmission 13.49 11.70 3 29277 15 42592040
Dermatitis exfoliative 13.43 11.70 20 29260 6927 42585128
Allergic reaction to excipient 13.41 11.70 4 29276 72 42591983
Liver injury 13.41 11.70 36 29244 19112 42572943
Atrial fibrillation 13.37 11.70 50 29230 139543 42452512
Hypersensitivity 13.16 11.70 90 29190 72280 42519775
Acne 13.13 11.70 29 29251 13615 42578440
Oesophagitis 13.12 11.70 31 29249 15216 42576839
Beta haemolytic streptococcal infection 13.09 11.70 8 29272 893 42591162
Alopecia scarring 13.03 11.70 3 29277 18 42592037
Low birth weight baby 12.97 11.70 24 29256 9931 42582124
Abscess limb 12.92 11.70 15 29265 4082 42587973
Headache 12.86 11.70 104 29176 239265 42352790
Fungal infection 12.74 11.70 36 29244 19686 42572369
Cyst 12.73 11.70 17 29263 5329 42586726
Hyperhidrosis 12.68 11.70 27 29253 90485 42501570
Debridement 12.52 11.70 8 29272 966 42591089
Clostridium difficile infection 12.40 11.70 39 29241 22620 42569435
Tenderness 12.32 11.70 22 29258 8861 42583194
Medical device site joint infection 12.25 11.70 4 29276 98 42591957
Folliculitis 12.21 11.70 17 29263 5541 42586514
Transient ischaemic attack 12.16 11.70 4 29276 33735 42558320
Sputum purulent 12.12 11.70 7 29273 705 42591350
Tracheitis 12.05 11.70 8 29272 1031 42591024
Muscle necrosis 12.01 11.70 8 29272 1037 42591018
Cytokine release syndrome 11.87 11.70 8 29272 44519 42547536
Limb fracture 11.87 11.70 3 29277 28 42592027
Ototoxicity 11.83 11.70 11 29269 2314 42589741
Bacteraemia 11.82 11.70 41 29239 24999 42567056
Multiple organ dysfunction syndrome 11.79 11.70 110 29170 96925 42495130
Bronchopulmonary dysplasia 11.72 11.70 7 29273 750 42591305

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1206.34 10.31 1428 65716 452662 110069493
Rash maculo-papular 825.64 10.31 531 66613 73691 110448464
Acute generalised exanthematous pustulosis 724.79 10.31 323 66821 21341 110500814
Drug reaction with eosinophilia and systemic symptoms 545.37 10.31 429 66715 81666 110440489
Rash 390.84 10.31 1238 65906 819726 109702429
Type IV hypersensitivity reaction 388.51 10.31 144 67000 5889 110516266
Toxic skin eruption 333.51 10.31 208 66936 27307 110494848
Drug ineffective 254.59 10.31 1682 65462 1518858 109003297
Clostridium difficile colitis 230.44 10.31 200 66944 43578 110478577
Hidradenitis 198.43 10.31 85 67059 5095 110517060
Drug resistance 171.79 10.31 191 66953 56183 110465972
Eosinophilia 164.14 10.31 189 66955 57747 110464408
Loss of employment 162.36 10.31 65 67079 3279 110518876
Erythema 152.24 10.31 455 66689 290992 110231163
Synovitis 144.08 10.31 5 67139 274087 110248068
Toxic epidermal necrolysis 135.99 10.31 170 66974 56557 110465598
Acute kidney injury 130.70 10.31 743 66401 634687 109887468
Pruritus 127.57 10.31 692 66452 580868 109941287
Abscess 112.36 10.31 109 67035 27360 110494795
Drug eruption 110.20 10.31 149 66995 53510 110468645
Rash morbilliform 106.27 10.31 64 67080 7887 110514268
Clostridium difficile infection 104.40 10.31 143 67001 51986 110470169
Tubulointerstitial nephritis 104.35 10.31 146 66998 54138 110468017
Graft infection 102.98 10.31 32 67112 756 110521399
Joint swelling 100.98 10.31 73 67071 442772 110079383
Glossodynia 98.89 10.31 10 67134 221994 110300161
Pseudomembranous colitis 97.39 10.31 56 67088 6335 110515820
Pemphigus 97.33 10.31 9 67135 214561 110307594
Systemic lupus erythematosus 95.75 10.31 19 67125 254319 110267836
Anti-cyclic citrullinated peptide antibody positive 93.30 10.31 4 67140 181980 110340175
Hand deformity 91.94 10.31 12 67132 218494 110303661
Pathogen resistance 91.49 10.31 80 67064 17592 110504563
Cholestasis 90.67 10.31 150 66994 64368 110457787
Cellulitis 90.09 10.31 221 66923 125795 110396360
Helicobacter infection 90.03 10.31 5 67139 181872 110340283
Drug ineffective for unapproved indication 89.64 10.31 195 66949 102643 110419512
Staphylococcal infection 88.24 10.31 155 66989 69789 110452366
Pericarditis 85.40 10.31 15 67129 219099 110303056
Death 83.70 10.31 188 66956 698681 109823474
Fibromyalgia 83.68 10.31 5 67139 170904 110351251
Oesophageal ulcer 83.58 10.31 55 67089 7909 110514246
Rash erythematous 82.83 10.31 165 66979 81667 110440488
Symmetrical drug-related intertriginous and flexural exanthema 78.88 10.31 33 67111 1864 110520291
Pyrexia 78.27 10.31 861 66283 897404 109624751
Urticaria 77.03 10.31 390 66754 318467 110203688
Cutaneous vasculitis 76.94 10.31 63 67081 12666 110509489
Stevens-Johnson syndrome 76.87 10.31 117 67027 46784 110475371
Multiple organ dysfunction syndrome 75.49 10.31 233 66911 151477 110370678
Oesophagitis 75.20 10.31 90 67054 28625 110493530
Leukocytosis 74.09 10.31 124 67020 53704 110468451
Muscle injury 69.29 10.31 4 67140 140803 110381352
Septic shock 68.48 10.31 231 66913 157297 110364858
Purpura 68.11 10.31 79 67065 24309 110497846
Hepatic steatosis 67.89 10.31 113 67031 48718 110473437
Vascular purpura 65.48 10.31 36 67108 3735 110518420
Drug abuse 65.21 10.31 14 67130 177397 110344758
Rheumatoid arthritis 63.67 10.31 53 67091 299560 110222595
Hepatic cytolysis 63.06 10.31 117 67027 54936 110467219
Alopecia 62.22 10.31 78 67066 364675 110157480
Anaphylactic reaction 60.10 10.31 179 66965 114121 110408034
Blood cholesterol increased 59.52 10.31 19 67125 184766 110337389
Type 2 diabetes mellitus 59.30 10.31 17 67127 177215 110344940
Infusion related reaction 53.78 10.31 93 67051 381069 110141086
Megacolon 53.30 10.31 33 67111 4272 110517883
Arthropathy 52.76 10.31 58 67086 287464 110234691
Wound 51.64 10.31 40 67104 234397 110287758
Face oedema 51.36 10.31 81 67063 33388 110488767
Hepatocellular injury 51.10 10.31 102 67042 50540 110471615
Irritable bowel syndrome 50.94 10.31 18 67126 164197 110357958
Methaemoglobinaemia 50.49 10.31 43 67101 9125 110513030
Folliculitis 49.30 10.31 20 67124 167633 110354522
Diarrhoea 49.20 10.31 967 66177 1138538 109383617
Osteoarthritis 48.70 10.31 25 67119 182598 110339557
Sinobronchitis 48.32 10.31 16 67128 466 110521689
Kounis syndrome 48.24 10.31 35 67109 5890 110516265
Lower respiratory tract infection 45.76 10.31 48 67096 243058 110279097
Lymphadenopathy 45.65 10.31 112 67032 63723 110458432
Stomatitis 44.81 10.31 59 67085 270183 110251972
Surgical failure 44.81 10.31 18 67126 916 110521239
Mobility decreased 44.55 10.31 47 67097 237375 110284780
Peripheral swelling 44.08 10.31 114 67030 403920 110118235
Facet joint syndrome 44.06 10.31 4 67140 96824 110425331
Fatigue 43.85 10.31 500 66644 1215458 109306697
Acne fulminans 43.19 10.31 13 67131 275 110521880
Hyper IgE syndrome 42.91 10.31 16 67128 665 110521490
Premature delivery 42.73 10.31 71 67073 30561 110491594
Necrotising fasciitis 42.62 10.31 36 67108 7555 110514600
Sleep disorder 42.36 10.31 35 67109 198609 110323546
Toxicity to various agents 42.12 10.31 150 66994 480405 110041750
Mucormycosis 41.27 10.31 41 67103 10587 110511568
Hepatitis cholestatic 41.06 10.31 52 67092 17514 110504641
Bartholinitis 40.93 10.31 9 67135 49 110522106
Lip dry 40.90 10.31 6 67138 100077 110422078
Erysipelas 40.79 10.31 45 67099 13113 110509042
Musculoskeletal stiffness 40.63 10.31 67 67077 279755 110242400
Confusional state 40.61 10.31 147 66997 468533 110053622
Clostridium test positive 40.42 10.31 41 67103 10852 110511303
Psoriatic arthropathy 40.33 10.31 36 67108 196725 110325430
Pulmonary fibrosis 39.71 10.31 7 67137 102035 110420120
Ill-defined disorder 39.59 10.31 23 67121 156830 110365325
Candida infection 39.52 10.31 89 67055 47920 110474235
Toxic shock syndrome 39.40 10.31 19 67125 1501 110520654
Glomerulosclerosis 39.39 10.31 18 67126 1259 110520896
Agranulocytosis 38.61 10.31 103 67041 61657 110460498
Hypercholesterolaemia 38.17 10.31 5 67139 90832 110431323
Hepatitis infectious mononucleosis 37.36 10.31 11 67133 215 110521940
Type I hypersensitivity 37.30 10.31 31 67113 6362 110515793
Asthenia 36.81 10.31 256 66888 688743 109833412
Rash pustular 36.57 10.31 42 67102 12787 110509368
Antibiotic level below therapeutic 36.42 10.31 9 67135 87 110522068
Drug-induced liver injury 36.40 10.31 157 66987 119910 110402245
Swelling face 36.30 10.31 131 67013 92190 110429965
Idiosyncratic drug reaction 36.22 10.31 18 67126 1518 110520637
Completed suicide 36.16 10.31 57 67087 242324 110279831
Rash macular 35.58 10.31 75 67069 38611 110483544
Grip strength decreased 34.70 10.31 4 67140 80170 110441985
Decreased appetite 34.48 10.31 160 66984 475686 110046469
Fungal infection 34.08 10.31 87 67057 50719 110471436
SAPHO syndrome 33.94 10.31 13 67131 582 110521573
General physical health deterioration 33.86 10.31 138 67006 425157 110096998
Discomfort 33.46 10.31 49 67095 214658 110307497
Cholestatic liver injury 33.46 10.31 31 67113 7345 110514810
Escherichia infection 32.95 10.31 55 67089 23761 110498394
Necrotising oesophagitis 32.63 10.31 17 67127 1583 110520572
Peripheral venous disease 32.24 10.31 6 67138 84111 110438044
Insomnia 31.95 10.31 112 67032 360478 110161677
Pustule 31.53 10.31 22 67122 3482 110518673
Klebsiella infection 31.50 10.31 49 67095 19960 110502195
Hypersensitivity vasculitis 31.17 10.31 29 67115 6908 110515247
Intentional product use issue 30.99 10.31 65 67079 247841 110274314
Subcutaneous abscess 30.86 10.31 33 67111 9284 110512871
Tubo-ovarian abscess 30.82 10.31 11 67133 403 110521752
Condition aggravated 30.73 10.31 621 66523 734215 109787940
Sciatica 30.65 10.31 9 67135 92390 110429765
Night sweats 30.61 10.31 22 67122 133961 110388194
Urine alcohol test positive 30.58 10.31 7 67137 47 110522108
Acute hepatic failure 30.46 10.31 68 67076 36400 110485755
Reaction to azo-dyes 30.14 10.31 6 67138 18 110522137
Intentional overdose 29.95 10.31 22 67122 132479 110389676
Central pain syndrome 29.91 10.31 13 67131 807 110521348
Dermatitis allergic 29.83 10.31 50 67094 21674 110500481
Toxic shock syndrome streptococcal 29.82 10.31 10 67134 303 110521852
Pneumonia 29.79 10.31 365 66779 876349 109645806
Acne 29.69 10.31 64 67080 33456 110488699
Lower limb fracture 29.69 10.31 5 67139 75343 110446812
Acute respiratory distress syndrome 29.57 10.31 85 67059 53113 110469042
Gait inability 29.11 10.31 24 67120 136352 110385803
Acute febrile neutrophilic dermatosis 28.93 10.31 24 67120 4912 110517243
Coma 28.74 10.31 18 67126 117851 110404304
Abscess of salivary gland 28.42 10.31 6 67138 26 110522129
Allergic sinusitis 28.19 10.31 16 67128 1765 110520390
Dysbiosis 28.07 10.31 17 67127 2115 110520040
Urinary tract inflammation 27.47 10.31 10 67134 388 110521767
Adverse event 27.39 10.31 16 67128 108793 110413362
Scrotal infection 27.26 10.31 12 67132 768 110521387
Overdose 27.01 10.31 64 67080 233730 110288425
Osteomyelitis 27.00 10.31 65 67079 36535 110485620
Skin exfoliation 26.86 10.31 115 67029 87536 110434619
Autoimmune disorder 26.58 10.31 4 67140 65479 110456676
Burn oesophageal 26.15 10.31 10 67134 446 110521709
Neoplasm progression 26.10 10.31 4 67140 64591 110457564
Conductive deafness 26.05 10.31 9 67135 299 110521856
Perineal infection 26.05 10.31 12 67132 855 110521300
Clostridial infection 25.75 10.31 25 67119 6277 110515878
Optic nerve operation 25.37 10.31 10 67134 484 110521671
Joint range of motion decreased 25.31 10.31 22 67122 121810 110400345
Bursitis 25.18 10.31 25 67119 129893 110392262
Gas gangrene 24.98 10.31 9 67135 339 110521816
Hypoglossal nerve paresis 24.92 10.31 7 67137 115 110522040
Epilepsy 24.85 10.31 15 67129 100194 110421961
Fungal sepsis 24.82 10.31 16 67128 2221 110519934
Swelling of eyelid 24.61 10.31 25 67119 6628 110515527
Gastric disorder 24.35 10.31 59 67085 33298 110488857
Prescribed underdose 24.24 10.31 5 67139 65169 110456986
Angioedema 24.10 10.31 121 67023 98379 110423776
Electrocardiogram U wave present 23.91 10.31 7 67137 134 110522021
Skin graft failure 23.87 10.31 8 67136 242 110521913
Abscess neck 23.59 10.31 13 67131 1355 110520800
Skin lesion 23.56 10.31 77 67067 51554 110470601
Scedosporium infection 23.45 10.31 16 67128 2442 110519713
Post infection glomerulonephritis 23.13 10.31 7 67137 151 110522004
Mastitis 22.87 10.31 16 67128 2542 110519613
Musculoskeletal pain 22.86 10.31 48 67096 182975 110339180
Aspergillus infection 22.79 10.31 49 67095 25567 110496588
Pneumococcal infection 22.66 10.31 14 67130 1805 110520350
Impaired healing 22.60 10.31 54 67090 196663 110325492
Eye swelling 22.59 10.31 57 67087 32991 110489164
Tendinous contracture 22.47 10.31 8 67136 291 110521864
Oedema 22.30 10.31 60 67084 209916 110312239
Pseudomonas infection 22.22 10.31 51 67093 27802 110494353
Type IIb hyperlipidaemia 22.19 10.31 5 67139 31 110522124
Dizziness 22.08 10.31 295 66849 697898 109824257
Wound secretion 22.08 10.31 24 67120 6877 110515278
Scar 22.05 10.31 38 67106 16843 110505312
Anaphylactic shock 21.86 10.31 75 67069 51471 110470684
Weight increased 21.84 10.31 157 66987 419487 110102668
Skin reaction 21.82 10.31 43 67101 21101 110501054
Puerperal pyrexia 21.79 10.31 5 67139 34 110522121
Micrococcus infection 21.78 10.31 7 67137 185 110521970
Coagulation factor decreased 21.40 10.31 8 67136 335 110521820
Tremor 21.32 10.31 58 67086 202174 110319981
Aeromonas infection 21.19 10.31 9 67135 528 110521627
Gait disturbance 21.06 10.31 92 67052 278116 110244039
Hepatic enzyme increased 20.87 10.31 112 67032 320780 110201375
Mononucleosis syndrome 20.72 10.31 7 67137 217 110521938
Idiopathic intracranial hypertension 20.67 10.31 18 67126 3934 110518221
Osteonecrosis of jaw 20.48 10.31 70 67074 47947 110474208
Memory impairment 20.37 10.31 57 67087 196887 110325268
Muscle necrosis 20.30 10.31 13 67131 1784 110520371
Erosive oesophagitis 20.27 10.31 16 67128 3053 110519102
Osteomyelitis salmonella 20.26 10.31 5 67139 48 110522107
Wheezing 20.18 10.31 83 67061 255147 110267008
Hepatic cirrhosis 19.98 10.31 8 67136 67618 110454537
Arteriovenous fistula 19.96 10.31 12 67132 1473 110520682
Autoimmune thyroiditis 19.93 10.31 22 67122 6412 110515743
Dermatitis acneiform 19.86 10.31 31 67113 12664 110509491
Hypoaesthesia 19.71 10.31 111 67033 314112 110208043
Product use in unapproved indication 19.64 10.31 381 66763 446996 110075159
Abscess limb 19.62 10.31 25 67119 8472 110513683
Medication error 19.59 10.31 21 67123 105345 110416810
Disease recurrence 19.59 10.31 81 67063 60703 110461452
Skin disorder 19.58 10.31 64 67080 42849 110479306
Overgrowth bacterial 19.42 10.31 7 67137 264 110521891
Anamnestic reaction 19.40 10.31 5 67139 58 110522097
Sedation 19.39 10.31 9 67135 69674 110452481
Eczema 19.26 10.31 91 67053 72202 110449953
Prescribed overdose 19.20 10.31 15 67129 87566 110434589
Rash pruritic 18.96 10.31 113 67031 97956 110424199
International normalised ratio increased 18.76 10.31 103 67041 86669 110435486
Haemolytic anaemia 18.59 10.31 40 67104 20880 110501275
Tendon pain 18.52 10.31 21 67123 6305 110515850
Dry mouth 18.45 10.31 61 67083 199887 110322268
Infected dermal cyst 18.40 10.31 11 67133 1337 110520818
Ophthalmoplegia 18.23 10.31 16 67128 3534 110518621
Renal tubular necrosis 18.22 10.31 50 67094 30425 110491730
Muscle spasms 18.14 10.31 97 67047 278060 110244095
Device toxicity 17.86 10.31 4 67140 24 110522131
Cerebral toxoplasmosis 17.84 10.31 15 67129 3127 110519028
Prothrombin time prolonged 17.69 10.31 35 67109 17226 110504929
Tooth injury 17.68 10.31 13 67131 2233 110519922
Cerebrovascular accident 17.64 10.31 54 67090 181230 110340925
Abdominal tenderness 17.54 10.31 29 67115 12428 110509727
Erythema multiforme 17.24 10.31 39 67105 21058 110501097
Clostridium colitis 17.14 10.31 15 67129 3300 110518855
Tonsillar hypertrophy 17.04 10.31 12 67132 1926 110520229
Fall 16.95 10.31 261 66883 603221 109918934
Dermatitis exfoliative 16.77 10.31 27 67117 11320 110510835
Cognitive disorder 16.77 10.31 17 67127 87494 110434661
Coeliac disease 16.72 10.31 3 67141 43184 110478971
Lip swelling 16.71 10.31 68 67076 50599 110471556
Sepsis syndrome 16.69 10.31 11 67133 1585 110520570
Vulval abscess 16.68 10.31 9 67135 900 110521255
Live birth 16.41 10.31 11 67133 69473 110452682
Dermatitis atopic 16.37 10.31 43 67101 25498 110496657
Sinus pain 16.34 10.31 19 67125 5860 110516295
Eosinophilic pneumonia 16.27 10.31 21 67123 7206 110514949
Anti factor V antibody positive 16.15 10.31 4 67140 39 110522116
Paraesthesia 16.11 10.31 100 67044 276421 110245734
Swelling 16.08 10.31 136 67008 350905 110171250
Wound infection 16.04 10.31 21 67123 96444 110425711
Pulmonary venous thrombosis 16.03 10.31 6 67138 252 110521903
Thyroxine increased 16.01 10.31 9 67135 975 110521180
Onychomadesis 15.98 10.31 4 67140 45659 110476496
Sialoadenitis 15.67 10.31 13 67131 2660 110519495
Wound complication 15.58 10.31 19 67125 6158 110515997
Torticollis 15.51 10.31 14 67130 3207 110518948
Shock 15.42 10.31 69 67075 53519 110468636
Respiratory failure 15.37 10.31 199 66945 215133 110307022
Nephritis allergic 15.24 10.31 9 67135 1070 110521085
Cyst 15.19 10.31 32 67112 16464 110505691
Renal failure 15.19 10.31 207 66937 226367 110295788
Injection site erythema 15.15 10.31 21 67123 94155 110428000
Haemodynamic instability 15.15 10.31 39 67105 22849 110499306
Pancytopenia 15.09 10.31 194 66950 209419 110312736
Rectocele repair 15.07 10.31 3 67141 9 110522146
Gastroenteritis yersinia 15.07 10.31 3 67141 9 110522146
Perihepatic discomfort 15.07 10.31 3 67141 9 110522146
Injury 15.06 10.31 56 67088 177209 110344946
Anterior segment ischaemia 15.04 10.31 4 67140 53 110522102
Tendon rupture 14.98 10.31 29 67115 14049 110508106
Orthostatic hypotension 14.97 10.31 11 67133 66238 110455917
Tinea infection 14.95 10.31 10 67134 1478 110520677
Odynophagia 14.95 10.31 29 67115 14072 110508083
Papule 14.82 10.31 24 67120 10109 110512046
Resorption bone increased 14.67 10.31 10 67134 1524 110520631
Drug intolerance 14.62 10.31 167 66977 406345 110115810
Weaning failure 14.57 10.31 8 67136 828 110521327
Acarodermatitis 14.55 10.31 11 67133 1970 110520185
Lemierre syndrome 14.53 10.31 5 67139 164 110521991
Skin odour abnormal 14.53 10.31 12 67132 2442 110519713
Gastrointestinal mucosa hyperaemia 14.42 10.31 7 67137 561 110521594
Vasculitis necrotising 14.38 10.31 10 67134 1573 110520582
Hip arthroplasty 14.34 10.31 8 67136 55805 110466350
Ototoxicity 14.34 10.31 15 67129 4116 110518039
Acinetobacter infection 14.28 10.31 14 67130 3559 110518596
Pulmonary function test 14.21 10.31 3 67141 13 110522142
Pneumonia staphylococcal 14.19 10.31 18 67126 6073 110516082
Bronchial obstruction 14.08 10.31 13 67131 3066 110519089
Leg amputation 14.08 10.31 15 67129 4203 110517952
Bacteraemia 14.07 10.31 57 67087 42333 110479822
Dermatitis 14.06 10.31 43 67101 27794 110494361
Neutrophil count decreased 14.05 10.31 33 67111 120908 110401247
Respiratory gas exchange disorder 14.03 10.31 8 67136 890 110521265
Night blindness 13.96 10.31 7 67137 602 110521553
Joint vibration 13.86 10.31 3 67141 15 110522140
Venous haemorrhage 13.83 10.31 6 67138 371 110521784
Oxygen saturation abnormal 13.74 10.31 17 67127 5594 110516561
Astigmatism 13.70 10.31 10 67134 1699 110520456
Drug interaction 13.67 10.31 399 66745 499784 110022371
Headache 13.61 10.31 420 66724 881957 109640198
Platelet count decreased 13.60 10.31 83 67061 230360 110291795
Oesophagitis chemical 13.60 10.31 4 67140 78 110522077
Frequent bowel movements 13.53 10.31 14 67130 71376 110450779
Breast abscess 13.53 10.31 10 67134 1731 110520424
Skin infection 13.52 10.31 37 67107 22472 110499683
Lupus-like syndrome 13.48 10.31 4 67140 40788 110481367
Soft tissue infection 13.36 10.31 16 67128 5091 110517064
Infectious mononucleosis 13.35 10.31 11 67133 2231 110519924
Contraindicated product administered 13.34 10.31 92 67052 248175 110273980
Adjustment disorder with depressed mood 13.28 10.31 5 67139 43878 110478277
Somnolence 13.28 10.31 116 67028 297333 110224822
Serratia infection 13.27 10.31 11 67133 2248 110519907
Upper limb fracture 13.22 10.31 35 67109 20853 110501302
Abdominal wall disorder 13.19 10.31 6 67138 415 110521740
Acute myocardial infarction 13.16 10.31 19 67125 83758 110438397
Myocardial infarction 13.07 10.31 66 67078 192017 110330138
Electrocardiogram U-wave abnormality 13.06 10.31 4 67140 90 110522065
Infected skin ulcer 13.05 10.31 14 67130 3953 110518202
Suicide attempt 13.00 10.31 27 67117 103367 110418788
Pneumothorax 12.97 10.31 49 67095 35236 110486919
Adenoidal disorder 12.95 10.31 5 67139 229 110521926
Post procedural fistula 12.91 10.31 6 67138 436 110521719
Premature rupture of membranes 12.91 10.31 15 67129 4622 110517533
Pain in extremity 12.89 10.31 213 66931 486905 110035250
Transient ischaemic attack 12.76 10.31 12 67132 63970 110458185
Postoperative wound infection 12.74 10.31 29 67115 15724 110506431
Allergy to animal 12.68 10.31 10 67134 1906 110520249
Nasopharyngitis 12.67 10.31 166 66978 394195 110127960
Fungaemia 12.64 10.31 17 67127 6069 110516086
Lower respiratory tract infection bacterial 12.63 10.31 8 67136 1077 110521078
Glomerulonephritis minimal lesion 12.59 10.31 8 67136 1083 110521072
Product contamination microbial 12.57 10.31 8 67136 1086 110521069
Nephropathy toxic 12.55 10.31 41 67103 27437 110494718
Interstitial lung disease 12.51 10.31 43 67101 139291 110382864
Lip oedema 12.51 10.31 19 67125 7581 110514574
Allergy to metals 12.50 10.31 7 67137 753 110521402
Drug effective for unapproved indication 12.49 10.31 27 67117 14140 110508015
Pyoderma gangrenosum 12.47 10.31 16 67128 5460 110516695
Oxygen saturation increased 12.43 10.31 7 67137 761 110521394
Groin abscess 12.42 10.31 10 67134 1962 110520193
Arthrofibrosis 12.33 10.31 4 67140 109 110522046
Obesity 12.33 10.31 32 67112 113319 110408836
Enanthema 12.31 10.31 8 67136 1126 110521029
Documented hypersensitivity to administered product 12.31 10.31 8 67136 1126 110521029
Babesiosis 12.26 10.31 6 67138 489 110521666
Serum sickness-like reaction 12.26 10.31 7 67137 781 110521374
Off label use 12.23 10.31 1063 66081 1499122 109023033
Rectal haemorrhage 12.16 10.31 35 67109 119798 110402357
Red blood cell sedimentation rate increased 12.07 10.31 18 67126 78284 110443871
Amnesia 12.05 10.31 29 67115 105379 110416776
Infective uveitis 12.05 10.31 3 67141 30 110522125
Axillary pain 11.99 10.31 11 67133 2575 110519580
Oesophagitis ulcerative 11.98 10.31 9 67135 1596 110520559
Oesophageal discomfort 11.95 10.31 6 67138 517 110521638
Renal arteriosclerosis 11.94 10.31 6 67138 518 110521637
Sensory disturbance 11.85 10.31 30 67114 17399 110504756
Dermal cyst 11.84 10.31 12 67132 3174 110518981
Geotrichum infection 11.83 10.31 8 67136 1204 110520951
Vestibular disorder 11.82 10.31 11 67133 2621 110519534
Lung neoplasm malignant 11.78 10.31 3 67141 33839 110488316
Vulvovaginal discomfort 11.77 10.31 10 67134 2114 110520041
Loss of personal independence in daily activities 11.72 10.31 49 67095 149971 110372184
Haemorrhagic vasculitis 11.69 10.31 4 67140 129 110522026
Retinal degeneration 11.68 10.31 9 67135 1657 110520498
BK polyomavirus test positive 11.56 10.31 5 67139 307 110521848
Gastrointestinal submucosal tumour 11.55 10.31 4 67140 134 110522021
Candida osteomyelitis 11.47 10.31 3 67141 37 110522118
Underdose 11.45 10.31 13 67131 63541 110458614
Sphingomonas paucimobilis infection 11.44 10.31 4 67140 138 110522017
Dysarthria 11.42 10.31 21 67123 84100 110438055
Blood alkaline phosphatase increased 11.40 10.31 78 67066 70857 110451298
White matter lesion 11.40 10.31 11 67133 2743 110519412
Nail disorder 11.39 10.31 11 67133 57924 110464231
Hepatic vein occlusion 11.36 10.31 5 67139 320 110521835
Urinary tract infection fungal 11.35 10.31 8 67136 1287 110520868
Bile output increased 11.33 10.31 3 67141 39 110522116
Limb fracture 11.33 10.31 3 67141 39 110522116
Contusion 11.32 10.31 89 67055 233272 110288883
Laryngeal ulceration 11.25 10.31 4 67140 145 110522010
Endocarditis histoplasma 11.19 10.31 3 67141 41 110522114
Pneumonia necrotising 11.18 10.31 9 67135 1766 110520389
Eosinophil count increased 11.08 10.31 33 67111 21025 110501130
Skin plaque 11.03 10.31 24 67120 12621 110509534
Disseminated intravascular coagulation 11.02 10.31 52 67092 41234 110480921
Cerebellar microhaemorrhage 10.99 10.31 3 67141 44 110522111
Skin candida 10.98 10.31 10 67134 2318 110519837
Wrong product administered 10.96 10.31 22 67122 10938 110511217
Dermatitis exfoliative generalised 10.95 10.31 22 67122 10950 110511205
Tooth infection 10.93 10.31 34 67110 22182 110499973
Menstrual disorder 10.92 10.31 14 67130 4770 110517385
Vitamin B1 deficiency 10.92 10.31 7 67137 963 110521192
Pneumatosis intestinalis 10.88 10.31 19 67125 8510 110513645
Crystal nephropathy 10.83 10.31 9 67135 1847 110520308
Vitamin A deficiency 10.80 10.31 4 67140 163 110521992
Umbilical hernia 10.78 10.31 17 67127 7005 110515150
Bullous haemorrhagic dermatosis 10.78 10.31 5 67139 362 110521793
Intracranial mass 10.76 10.31 10 67134 2378 110519777
Product quality issue 10.76 10.31 19 67125 77280 110444875
Biopsy liver 10.70 10.31 6 67138 647 110521508
Hypervigilance 10.66 10.31 6 67138 651 110521504
Gastrointestinal bacterial overgrowth 10.61 10.31 6 67138 657 110521498
Localised infection 10.61 10.31 53 67091 42995 110479160
Oral infection 10.61 10.31 16 67128 6345 110515810
Microsporidia infection 10.59 10.31 8 67136 1431 110520724
Skin test positive 10.54 10.31 8 67136 1441 110520714
Eye discharge 10.52 10.31 19 67125 8735 110513420
Ischaemic stroke 10.48 10.31 6 67138 41257 110480898
Road traffic accident 10.44 10.31 32 67112 107366 110414789
Blood pressure diastolic increased 10.40 10.31 30 67114 18777 110503378
Factor V inhibition 10.36 10.31 5 67139 396 110521759
Drug clearance increased 10.34 10.31 5 67139 397 110521758

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D10AF01 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
ATC D10AF51 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
ATC G01AA10 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
ATC J01FF01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Lincosamides
FDA CS M0515779 Lincosamides
FDA PE N0000009982 Decreased Sebaceous Gland Activity
FDA EPC N0000175443 Lincosamide Antibacterial
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminant
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
FDA PE N0000175731 Neuromuscular Blockade

Related Drugs by ATC class:

D10AF Antiinfectives for treatment of acne 6 drugs
chloramphenicolerythromycinmeclocyclineminocyclinenadifloxacinsulfacetamide
G01AA Antibiotics 10 drugs
amphotericin Bcandicidincarfecillinchloramphenicolhachimycinmepartricinnatamycinnystatinoxytetracyclinepentamycin
J01FF Lincosamides 1 drug
lincomycin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anaerobic septicemia indication 1976008
Bacterial septicemia indication 10001005 DOID:0040085
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Streptococcal septicemia indication 29577008
Pneumonia due to Streptococcus indication 34020007
Empyema of pleura indication 58554001 DOID:3798
Acne vulgaris indication 88616000
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Infectious disease of abdomen indication 128070006
Pneumococcal pneumonia indication 233607000
Gas gangrene caused by clostridium perfringens indication 266093005
Streptococcus pyogenes infection indication 302809008
Infectious disorder of joint indication 363162000
Infection due to Staphylococcus aureus indication 406602003
Bacterial vaginosis indication 419760006 DOID:3385
Aspiration pneumonia indication 422588002 DOID:3240
Infection due to anaerobic bacteria indication 423451008
Osteomyelitis due to Staphylococcus aureus indication 428783003
Inflammatory Disease of Female Pelvic Organs indication
Anaerobic Joint Infection indication
Anaerobic Tubo-Ovarian Abscess indication
Prevention of Bacterial Endocarditis indication
Anaerobic Peritonitis indication
Clostridium Perfringens Empyema indication
Anaerobic Pelvic Cellulitis indication
Anaerobic Lung Abscess indication
Skin and Skin Structure Anaerobic Infection indication
Bacteroides Endomyometritis indication
Anaerobic Endometritis indication
Intra-Abdominal Anaerobic Abscess indication
Pyrexia of unknown origin off-label use 7520000
Inhalational anthrax off-label use 11389007
Actinomycotic infection off-label use 11817007 DOID:8478
Babesiosis off-label use 21061004 DOID:9643
Sinusitis off-label use 36971009
Erysipelas off-label use 44653001 DOID:11330
Malaria off-label use 61462000 DOID:12365
Acute bacterial sinusitis off-label use 75498004
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Bacterial infection of skin off-label use 128936008
Toxoplasmosis off-label use 187192000 DOID:9965
Diverticulitis of gastrointestinal tract off-label use 271366000
Infective otitis media off-label use 312218008
Rosacea off-label use 398909004 DOID:8881
Anthrax off-label use 409498004 DOID:7427
Pneumocystosis jiroveci pneumonia off-label use 415125002 DOID:11339
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Diabetic Foot Infection off-label use
Chloroquine Resistant Plasmodium Falciparum Malaria off-label use
Encephalitis due to Toxoplasmosis off-label use
Diabetic Foot Infection Due to Gram-Positive Bacteria off-label use
Gardnerella Vaginalis Bacterial Vaginosis off-label use
Sunburn contraindication 23346002
Atopic dermatitis contraindication 24079001 DOID:3310
Crohn's disease contraindication 34000006
Eczema contraindication 43116000
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Candidal vulvovaginitis contraindication 72605008 DOID:2272
Pregnancy, function contraindication 289908002
Pseudomembranous enterocolitis contraindication 397683000
Erythroderma contraindication 399992009
Breastfeeding (mother) contraindication 413712001
Inflammatory dermatosis contraindication 703938007
Bloody Stools contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Skin infections caused by Staphylococcus aureus Indication
Cats Skin infections caused by S intermedius Indication
Cats Skin infections caused by Streptococcus species Indication
Cats Deep wounds and abscesses caused by Clostridium perfringens Indication
Cats Deep wounds and abscesses caused by Bacteroides fragilis Indication
Cats Dental infections caused by Staphylococcus aureus Indication
Cats Dental infections caused by S intermedius Indication
Cats Dental infections caused by Streptococcus species Indication
Cats Dental infections caused by C perfringens Indication
Cats Dental infections caused by B fragilis Indication
Dogs Skin infections caused by coagulase-positive staphylococci Indication
Dogs Deep wounds and abscesses caused by Bacteroides fragilis Indication
Dogs Deep wounds and abscesses caused by Prevotella melaninogenicus Indication
Dogs Deep wounds and abscesses caused by Fusobacterium necrophorum Indication
Dogs Deep wounds and abscesses caused by Clostridium perfringens Indication
Dogs Dental infections caused by Staphylococcus aureus Indication
Dogs Dental infections caused by B fragilis Indication
Dogs Dental infections caused by P melaninogenicus Indication
Dogs Dental infections caused by F necrophorum Indication
Dogs Dental infections caused by C perfringens Indication
Dogs Osteomyelitis caused by Staphylococcus aureus Indication
Dogs Osteomyelitis caused by B fragilis Indication
Dogs Osteomyelitis caused by P melaninogenicus Indication
Dogs Osteomyelitis caused by F necrophorum Indication
Dogs Osteomyelitis caused by C perfringens Indication

🐶 Veterinary products

ProductApplicantIngredients
Antirobe Capsules Zoetis Inc. 1
Antirobe Aquadrops Zoetis Inc. 1
Clindamycin Hydrochloride Oral Liquid Cronus Pharma Specialities India Private Limited 1
Clinsol Virbac AH Inc. 1
Clindamycin Hydrochloride Capsules Cronus Pharma Specialities India Private Limited 1
Clintabs Virbac AH Inc. 1
Clindamycin Hydrochloride Oral Drops First Priority Inc. 1
ClindaMed Oral Drops Bimeda Animal Health Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.85 acidic
pKa2 13.38 acidic
pKa3 7.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
50S ribosomal protein L10 Ribosomal protein WOMBAT-PK

External reference:

IDSource
4019683 VUID
N0000147775 NUI
D00277 KEGG_DRUG
21462-39-5 SECONDARY_CAS_RN
2582 RXNORM
C0008947 UMLSCUI
CHEBI:3745 CHEBI
CLY PDB_CHEM_ID
CHEMBL1753 ChEMBL_ID
CHEMBL1200588 ChEMBL_ID
D002981 MESH_DESCRIPTOR_UI
DB01190 DRUGBANK_ID
446598 PUBCHEM_CID
10607 IUPHAR_LIGAND_ID
2550 INN_ID
3U02EL437C UNII
11401 MMSL
4466 MMSL
4467 MMSL
d00043 MMSL
002794 NDDF
002795 NDDF
372786004 SNOMEDCT_US
58883005 SNOMEDCT_US
63084001 SNOMEDCT_US
4018082 VANDF
4019683 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0225 CAPSULE 150 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0225 CAPSULE 150 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0331 CAPSULE 75 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0331 CAPSULE 75 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0395 CAPSULE 300 mg ORAL NDA 27 sections
Cleocin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0009-0395 CAPSULE 300 mg ORAL NDA 27 sections
Clindamycin in 5 percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0143-9267 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 20 sections
Clindamycin in 5 percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0143-9268 INJECTION, SOLUTION 12 mg INTRAVENOUS ANDA 20 sections
Clindamycin in 5 percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0143-9269 INJECTION, SOLUTION 18 mg INTRAVENOUS ANDA 20 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3288 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3289 INJECTION, SOLUTION 12 mg INTRAVENOUS ANDA 24 sections
Clindamycin in 5 Percent Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0781-3290 INJECTION, SOLUTION 18 mg INTRAVENOUS ANDA 24 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-5959 CAPSULE 150 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7194 CAPSULE 300 mg ORAL ANDA 24 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-153 CAPSULE 150 mg ORAL ANDA 25 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-154 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 12634-092 CAPSULE 150 mg ORAL ANDA 24 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16590-057 CAPSULE 150 mg ORAL ANDA 13 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-033 CAPSULE 150 mg ORAL ANDA 25 sections
clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-034 CAPSULE 300 mg ORAL ANDA 25 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-159 CAPSULE 150 mg ORAL ANDA 24 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-448 CAPSULE 300 mg ORAL ANDA 24 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-532 CAPSULE 150 mg ORAL ANDA 24 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42571-250 CAPSULE 75 mg ORAL ANDA 23 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42571-251 CAPSULE 150 mg ORAL ANDA 23 sections
CLINDAMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42571-252 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride Human Prescription Drug Label 1 50090-0443 CAPSULE 150 mg ORAL ANDA 24 sections
Clindamycin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0967 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-1798 CAPSULE 300 mg ORAL ANDA 23 sections
Clindamycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-1951 CAPSULE 150 mg ORAL ANDA 23 sections