salbutamol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 105 18559-94-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salbutamol
  • albuterol
  • sabumol
  • dl-Albuterol
  • dl-Salbutamol
  • albuterol sulfate
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
  • Molecular weight: 239.32
  • Formula: C13H21NO3
  • CLOGP: 0.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -2.05
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
10 mg Inhal.solution
12 mg O
12 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.23 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.92 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 1, 1981 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 8433.43 9.91 6566 370477 106204 55808820
Wheezing 3090.43 9.91 3121 373922 71905 55843119
Dyspnoea 2404.77 9.91 9040 368003 583537 55331487
Obstructive airways disorder 1728.33 9.91 1202 375841 16080 55898944
Product quality issue 1425.16 9.91 1385 375658 30351 55884673
Cough 1422.09 9.91 4392 372651 255569 55659455
Poor quality device used 1354.00 9.91 504 376539 1432 55913592
Chronic obstructive pulmonary disease 1346.88 9.91 1788 375255 55627 55859397
Sleep disorder due to a general medical condition 1199.86 9.91 752 376291 8338 55906686
Full blood count abnormal 1141.72 9.91 1130 375913 25332 55889692
Productive cough 1035.50 9.91 1560 375483 54672 55860352
Pemphigus 993.27 9.91 11 377032 157201 55757823
Rheumatoid arthritis 935.67 9.91 718 376325 381886 55533138
Forced expiratory volume decreased 887.99 9.91 489 376554 4171 55910853
Synovitis 793.50 9.91 80 376963 161225 55753799
Hand deformity 783.67 9.91 26 377017 134466 55780558
Chest discomfort 772.32 9.91 1905 375138 96952 55818072
Sputum discoloured 749.38 9.91 680 376363 13612 55901412
Systemic lupus erythematosus 749.15 9.91 148 376895 179930 55735094
Glossodynia 723.53 9.91 86 376957 152372 55762652
Infective pulmonary exacerbation of cystic fibrosis 711.07 9.91 522 376521 7635 55907389
Treatment failure 656.51 9.91 166 376877 170226 55744798
Drug intolerance 653.01 9.91 492 376551 264326 55650698
Completed suicide 651.38 9.91 69 376974 133764 55781260
Arthropathy 646.59 9.91 266 376777 200009 55715015
Pneumonia 598.62 9.91 4714 372329 402384 55512640
Alopecia 593.08 9.91 655 376388 292803 55622221
Drug ineffective 558.79 9.91 3742 373301 915247 54999777
Anti-cyclic citrullinated peptide antibody positive 557.40 9.91 24 377019 98576 55816448
Contraindicated product administered 549.09 9.91 281 376762 186005 55729019
Bronchitis 532.05 9.91 1809 375234 110502 55804522
Pericarditis 517.78 9.91 61 376982 108862 55806162
Device delivery system issue 515.80 9.91 181 376862 407 55914617
Off label use 494.73 9.91 1985 375058 554195 55360829
Wound 448.38 9.91 184 376859 138620 55776404
Therapeutic product effect incomplete 420.62 9.91 1612 375431 104419 55810605
Abdominal discomfort 392.56 9.91 791 376252 276483 55638541
Infusion related reaction 377.70 9.91 508 376535 208423 55706601
Therapeutic product effect decreased 375.23 9.91 349 376694 169103 55745921
Product dose omission issue 374.22 9.91 2500 374543 202253 55712771
Hepatic enzyme increased 365.52 9.91 365 376678 171019 55744005
Duodenal ulcer perforation 360.32 9.91 25 377018 68317 55846707
Helicobacter infection 353.26 9.91 39 377004 73229 55841795
Respiratory disorder 344.41 9.91 726 376317 33231 55881793
Nasal congestion 295.39 9.91 940 376103 55430 55859594
Maternal exposure during pregnancy 295.24 9.91 510 376533 189043 55725981
Middle insomnia 289.39 9.91 362 376681 10588 55904436
Dyspnoea exertional 282.96 9.91 908 376135 53781 55861243
Discomfort 276.59 9.91 325 376718 141436 55773588
Eosinophil count increased 271.46 9.91 329 376714 9308 55905716
Neutropenia 258.85 9.91 412 376631 157755 55757269
Nasal polyps 255.75 9.91 196 376847 3069 55911955
No adverse event 248.63 9.91 667 376376 35707 55879317
Ear pain 248.06 9.91 602 376441 30288 55884736
Toxicity to various agents 247.19 9.91 730 376313 223834 55691190
Sleep apnoea syndrome 245.70 9.91 541 376502 25520 55889504
Swelling 243.79 9.91 808 376235 238963 55676061
Pulmonary function test decreased 243.48 9.91 198 376845 3393 55911631
Loss of personal independence in daily activities 241.62 9.91 1133 375910 80236 55834788
Upper respiratory tract infection 236.66 9.91 1026 376017 70262 55844762
Drug abuse 234.35 9.91 80 376963 67530 55847494
Rheumatoid factor positive 230.38 9.91 87 376956 68973 55846051
Blood immunoglobulin E increased 229.94 9.91 178 376865 2831 55912193
Joint swelling 226.53 9.91 1084 375959 288716 55626308
Bronchospasm 205.04 9.91 373 376670 15296 55899728
Gastrooesophageal reflux disease 203.27 9.91 1097 375946 82160 55832864
Musculoskeletal stiffness 200.66 9.91 469 376574 155538 55759486
Lower respiratory tract infection 198.89 9.91 1384 375659 113410 55801614
Thrombocytopenia 196.46 9.91 384 376659 135840 55779184
Intentional overdose 194.24 9.91 107 376936 68010 55847014
Febrile neutropenia 193.21 9.91 254 376789 105291 55809733
Bronchiectasis 191.76 9.91 304 376739 11130 55903894
Sinusitis 191.07 9.91 2094 374949 195487 55719537
Breath sounds abnormal 190.53 9.91 267 376776 8740 55906284
Impaired healing 182.66 9.91 187 376856 86654 55828370
Dysphonia 178.02 9.91 652 376391 41295 55873729
Oropharyngeal pain 174.35 9.91 1058 375985 82730 55832294
Body temperature increased 173.89 9.91 565 376478 33677 55881347
Rhinitis allergic 173.04 9.91 247 376796 8227 55906797
Influenza 173.01 9.91 1162 375881 94099 55820925
Cystic fibrosis 172.97 9.91 160 376883 3284 55911740
Sedation complication 172.34 9.91 293 376750 11379 55903645
Arthralgia 171.23 9.91 2350 374693 499319 55415705
Folliculitis 170.86 9.91 77 376966 54902 55860122
Rales 167.90 9.91 278 376765 10562 55904462
Urticaria 167.39 9.91 1591 375452 143085 55771939
Rheumatic fever 166.30 9.91 6 377037 28821 55886203
Pancytopenia 165.98 9.91 210 376833 88505 55826519
Malignant neoplasm progression 164.59 9.91 150 376893 73437 55841587
Muscle injury 163.98 9.91 73 376970 52427 55862597
General physical health deterioration 161.84 9.91 589 376454 169421 55745603
Drug interaction 159.47 9.91 792 376251 208963 55706061
Liver injury 158.65 9.91 42 377001 41806 55873218
Food allergy 156.88 9.91 241 376802 8583 55906441
Respiratory tract infection 156.73 9.91 565 376478 35506 55879518
Heart rate increased 154.96 9.91 1022 376021 82251 55832773
Reversible airways obstruction 151.90 9.91 102 376941 1282 55913742
Upper-airway cough syndrome 148.81 9.91 244 376799 9194 55905830
Secretion discharge 148.20 9.91 259 376784 10287 55904737
Sleep disorder due to general medical condition, insomnia type 145.53 9.91 54 376989 43284 55871740
Stomatitis 143.72 9.91 378 376665 120432 55794592
Asthmatic crisis 143.56 9.91 107 376936 1603 55913421
Swollen joint count increased 143.21 9.91 4 377039 24180 55890844
Chest pain 141.82 9.91 1916 375127 187881 55727143
Device malfunction 140.96 9.91 325 376718 15811 55899213
Emphysema 140.18 9.91 245 376798 9731 55905293
Respiratory tract congestion 139.49 9.91 317 376726 15274 55899750
Anaemia 135.95 9.91 1142 375901 266369 55648655
Peak expiratory flow rate decreased 135.37 9.91 71 376972 543 55914481
Creatinine renal clearance decreased 133.58 9.91 299 376744 14260 55900764
Sensitivity to weather change 131.66 9.91 191 376852 6458 55908566
Oxygen saturation decreased 130.89 9.91 943 376100 78124 55836900
Anxiety 130.62 9.91 1916 375127 191256 55723768
Forced vital capacity decreased 129.66 9.91 82 376961 924 55914100
Eosinophilic bronchitis 129.43 9.91 65 376978 449 55914575
Eosinophilic granulomatosis with polyangiitis 127.99 9.91 108 376935 1953 55913071
Seasonal allergy 127.41 9.91 324 376719 16784 55898240
Leukopenia 122.50 9.91 178 376865 70762 55844262
Blood test abnormal 120.05 9.91 265 376778 12519 55902505
Respiration abnormal 117.51 9.91 166 376877 5475 55909549
Lung hyperinflation 116.62 9.91 82 376961 1116 55913908
Bronchopulmonary aspergillosis allergic 115.89 9.91 88 376955 1358 55913666
Polycystic ovaries 114.99 9.91 126 376917 3188 55911836
Haemoptysis 114.51 9.91 415 376628 26145 55888879
White blood cell count decreased 113.68 9.91 446 376597 125544 55789480
Psoriatic arthropathy 112.48 9.91 202 376841 73806 55841218
Product container issue 111.28 9.91 88 376955 1446 55913578
Irritable bowel syndrome 111.26 9.91 179 376864 68279 55846745
Hip arthroplasty 111.07 9.91 60 376983 38563 55876461
Eosinophil count abnormal 110.32 9.91 58 376985 446 55914578
Headache 110.05 9.91 4683 372360 554361 55360663
Orthostatic hypotension 109.49 9.91 477 376566 32722 55882302
Muscle spasticity 109.25 9.91 338 376705 19622 55895402
Platelet count decreased 108.30 9.91 358 376685 106025 55808999
Blister 107.73 9.91 371 376672 108516 55806508
Sinus disorder 106.96 9.91 344 376699 20390 55894634
Illness 106.40 9.91 486 376557 34025 55880999
C-reactive protein increased 104.78 9.91 232 376811 78452 55836572
Temperature regulation disorder 104.41 9.91 139 376904 4329 55910695
Respiratory rate increased 103.09 9.91 243 376800 11994 55903030
Bronchial secretion retention 100.10 9.91 90 376953 1778 55913246
Sputum increased 99.62 9.91 95 376948 2029 55912995
Malaise 98.50 9.91 3190 373853 364670 55550354
Respiratory distress 98.41 9.91 447 376596 31220 55883804
Product use issue 97.72 9.91 787 376256 185254 55729770
Hepatic function abnormal 97.47 9.91 55 376988 34503 55880521
Hypoventilation 97.10 9.91 133 376910 4259 55910765
Intentional product use issue 96.52 9.91 343 376700 99390 55815634
Blood calcium decreased 96.28 9.91 364 376679 23405 55891619
Circumstance or information capable of leading to medication error 95.95 9.91 117 376926 3331 55911693
Impaired quality of life 95.14 9.91 189 376854 8285 55906739
Lip swelling 94.82 9.91 388 376655 25884 55889140
Sopor 93.91 9.91 14 377029 20908 55894116
Knee arthroplasty 93.39 9.91 95 376948 44164 55870860
Bronchial obstruction 92.98 9.91 76 376967 1312 55913712
Status asthmaticus 92.65 9.91 64 376979 845 55914179
Pulmonary mass 92.65 9.91 325 376718 20145 55894879
Hepatocellular injury 92.51 9.91 31 377012 26483 55888541
Hepatotoxicity 91.64 9.91 47 376996 31106 55883918
Bronchospasm paradoxical 90.93 9.91 30 377013 51 55914973
Throat clearing 90.57 9.91 78 376965 1452 55913572
Respiratory symptom 89.80 9.91 102 376941 2688 55912336
Acute respiratory failure 89.33 9.91 428 376615 30566 55884458
Sensitisation 89.14 9.91 94 376949 2274 55912750
Dust allergy 89.08 9.91 54 376989 561 55914463
Product delivery mechanism issue 88.82 9.91 44 376999 294 55914730
Rhinorrhoea 88.53 9.91 670 376373 56367 55858657
Sputum purulent 87.39 9.91 64 376979 932 55914092
Bronchial wall thickening 87.16 9.91 66 376977 1014 55914010
Vital capacity decreased 85.18 9.91 70 376973 1218 55913806
Allergy to animal 83.96 9.91 62 376981 915 55914109
Suicide attempt 83.35 9.91 163 376880 57673 55857351
Hospitalisation 83.31 9.91 818 376225 74182 55840842
Rhinitis 82.79 9.91 184 376859 8732 55906292
Anaphylactic reaction 81.68 9.91 675 376368 58320 55856704
Coma 79.33 9.91 176 376867 59479 55855545
Swollen tongue 79.06 9.91 407 376636 29917 55885107
Eczema 78.18 9.91 365 376678 25788 55889236
Pulmonary function test abnormal 78.02 9.91 70 376973 1379 55913645
Renal impairment 77.81 9.91 278 376765 80435 55834589
Myelosuppression 77.61 9.91 12 377031 17443 55897581
Throat tightness 76.23 9.91 325 376718 22082 55892942
Drug-induced liver injury 76.15 9.91 71 376972 34391 55880633
Back pain 75.04 9.91 2100 374943 235070 55679954
Humidity intolerance 74.43 9.91 38 377005 273 55914751
Alanine aminotransferase increased 74.38 9.91 348 376695 93314 55821710
Total lung capacity increased 73.86 9.91 57 376986 902 55914122
Red blood cell sedimentation rate increased 73.48 9.91 82 376961 36541 55878483
Blood cholesterol increased 73.33 9.91 245 376798 72334 55842690
Night sweats 73.14 9.91 500 376543 40713 55874311
Restrictive pulmonary disease 72.99 9.91 69 376974 1457 55913567
Cardio-respiratory arrest 72.92 9.91 164 376879 55157 55859867
Therapy non-responder 72.91 9.91 192 376851 61163 55853861
Bone marrow failure 72.88 9.91 50 376993 28236 55886788
Sedation 72.38 9.91 440 376603 34414 55880610
Cytomegalovirus infection 71.94 9.91 20 377023 19276 55895748
Pharyngeal swelling 70.29 9.91 127 376916 5179 55909845
Viral infection 70 9.91 409 376634 31537 55883487
Metastases to liver 69.01 9.91 29 377014 21557 55893467
Choking 68.67 9.91 172 376871 8825 55906199
C-reactive protein abnormal 67.92 9.91 88 376955 36721 55878303
Drug tolerance decreased 67.60 9.91 6 377037 13405 55901619
Product cleaning inadequate 67.09 9.91 18 377025 6 55915018
Dermatitis atopic 66.89 9.91 162 376881 8137 55906887
Product complaint 66.08 9.91 201 376842 11559 55903465
Chronic sinusitis 65.88 9.91 162 376881 8216 55906808
Rash 65.37 9.91 2670 374373 490377 55424647
Ejection fraction 64.42 9.91 68 376975 1647 55913377
Aspartate aminotransferase increased 63.77 9.91 310 376733 82292 55832732
Drug hypersensitivity 63.54 9.91 1382 375661 273823 55641201
Perfume sensitivity 63.32 9.91 46 376997 661 55914363
Coeliac disease 63.13 9.91 182 376861 10157 55904867
Disease progression 62.78 9.91 429 376614 104744 55810280
Rhonchi 62.76 9.91 79 376964 2325 55912699
Mucosal inflammation 62.25 9.91 120 376923 42690 55872334
Burning sensation 61.54 9.91 546 376497 48150 55866874
Hypoxia 61.40 9.91 591 376452 53306 55861718
Balance disorder 61.02 9.91 782 376261 75738 55839286
Condition aggravated 60.84 9.91 1802 375241 343096 55571928
Emotional distress 60.71 9.91 374 376669 29389 55885635
Nasal obstruction 60.67 9.91 57 376986 1194 55913830
Palpitations 60.12 9.91 970 376073 98702 55816322
Toxic epidermal necrolysis 59.45 9.91 37 377006 22005 55893019
Multiple organ dysfunction syndrome 59.07 9.91 170 376873 52600 55862424
Sneezing 58.70 9.91 233 376810 15327 55899697
Femur fracture 58.14 9.91 109 376934 39186 55875838
Gastrointestinal disorder 58.10 9.91 479 376564 112223 55802801
Neurotoxicity 57.72 9.91 17 377026 15778 55899246
Total lung capacity decreased 57.64 9.91 60 376983 1429 55913595
Decreased appetite 57.43 9.91 1078 375965 218153 55696871
Posterior reversible encephalopathy syndrome 56.84 9.91 18 377025 15942 55899082
Overdose 56.76 9.91 445 376598 105385 55809639
Smoke sensitivity 56.67 9.91 35 377008 377 55914647
Drug reaction with eosinophilia and systemic symptoms 56.38 9.91 72 376971 30232 55884792
Multiple allergies 55.83 9.91 176 376867 10320 55904704
Inflammation 55.80 9.91 255 376788 68816 55846208
Acute kidney injury 54.99 9.91 1211 375832 239552 55675472
Serotonin syndrome 54.60 9.91 58 376985 26432 55888592
Agranulocytosis 54.56 9.91 43 377000 22616 55892408
Confusional state 54.38 9.91 1024 376019 207131 55707893
Mite allergy 54.36 9.91 38 377005 512 55914512
Bronchial hyperreactivity 54.31 9.91 59 376984 1478 55913546
Death 54.13 9.91 1809 375234 339617 55575407
Paranasal sinus discomfort 54.02 9.91 88 376955 3297 55911727
Asthma-chronic obstructive pulmonary disease overlap syndrome 53.68 9.91 42 377001 679 55914345
Neoplasm progression 53.64 9.91 82 376961 31934 55883090
Wrong technique in device usage process 53.62 9.91 82 376961 2908 55912116
Eosinophilia 52.70 9.91 270 376773 19807 55895217
Cognitive disorder 52.67 9.91 532 376511 48601 55866423
Fluid retention 52.54 9.91 574 376469 53504 55861520
Rheumatoid nodule 52.48 9.91 17 377026 14840 55900184
Conjunctivitis allergic 52.48 9.91 43 377000 745 55914279
Cholecystitis chronic 52.35 9.91 164 376879 9584 55905440
Drug resistance 52.01 9.91 37 377006 20505 55894519
Incorrect dose administered 51.63 9.91 559 376484 51988 55863036
Polyp 50.05 9.91 118 376925 5824 55909200
Sinus pain 50.03 9.91 75 376968 2613 55912411
Cholestasis 50.01 9.91 64 376979 26849 55888175
Nasal turbinate hypertrophy 49.79 9.91 40 377003 673 55914351
Nasal discharge discolouration 49.77 9.91 62 376981 1805 55913219
Pulmonary embolism 49.58 9.91 1000 376043 106124 55808900
Poisoning deliberate 48.72 9.91 5 377038 9948 55905076
Lower respiratory tract congestion 48.48 9.91 70 376973 2356 55912668
Prolonged expiration 48.26 9.91 43 377000 839 55914185
Blood pressure systolic increased 48.10 9.91 451 376592 40385 55874639
Fatigue 48.05 9.91 4590 372453 783962 55131062
Respiratory tract inflammation 47.98 9.91 36 377007 545 55914479
Throat irritation 47.97 9.91 379 376664 32304 55882720
Altered state of consciousness 47.90 9.91 50 376993 22971 55892053
Lung diffusion test abnormal 47.61 9.91 27 377016 245 55914779
Hiatus hernia 47.28 9.91 258 376785 19394 55895630
Depression 46.78 9.91 1557 375486 178560 55736464
Infective exacerbation of chronic obstructive airways disease 46.71 9.91 47 376996 1074 55913950
Insomnia 46.44 9.91 1645 375398 190215 55724809
Bronchial disorder 46.39 9.91 48 376995 1135 55913889
Increased upper airway secretion 46.23 9.91 81 376962 3223 55911801
Aphonia 45.84 9.91 149 376894 8880 55906144
Cerebral infarction 45.58 9.91 50 376993 22455 55892569
Exposure during pregnancy 45.08 9.91 642 376401 135700 55779324
Neutrophil count decreased 44.50 9.91 177 376866 49645 55865379
Eye pruritus 44.48 9.91 201 376842 14005 55901019
Nasal mucosal disorder 44.14 9.91 31 377012 421 55914603
Prescribed underdose 43.78 9.91 44 376999 20573 55894451
Inhalation therapy 43.59 9.91 15 377028 31 55914993
Palmar-plantar erythrodysaesthesia syndrome 43.55 9.91 46 376997 21019 55894005
Metastases to bone 43.33 9.91 40 377003 19468 55895556
Lung neoplasm malignant 42.27 9.91 229 376814 17167 55897857
Increased bronchial secretion 42.25 9.91 53 376990 1554 55913470
Shock 42.13 9.91 50 376993 21678 55893346
Lung diffusion test decreased 41.61 9.91 35 377008 630 55914394
Panniculitis 41.05 9.91 8 377035 9834 55905190
Septic shock 41.00 9.91 239 376804 60596 55854428
Epilepsy 40.96 9.91 66 376977 25165 55889859
Anuria 40.59 9.91 14 377029 11746 55903278
Vocal cord dysfunction 40.39 9.91 28 377015 372 55914652
Nasopharyngitis 40.35 9.91 1838 375205 219121 55695903
Drug eruption 40.33 9.91 69 376974 25694 55889330
Lung disorder 40.03 9.91 533 376510 52064 55862960
Swelling face 39.34 9.91 560 376483 55509 55859515
Osteonecrosis of jaw 39.16 9.91 105 376938 33253 55881771
Blood parathyroid hormone decreased 38.94 9.91 5 377038 8359 55906665
Lung opacity 38.92 9.91 62 376981 2279 55912745
Pneumocystis jirovecii pneumonia 38.81 9.91 29 377014 15672 55899352
Cystic fibrosis respiratory infection suppression 38.74 9.91 24 377019 260 55914764
Product taste abnormal 38.50 9.91 55 376988 1833 55913191
Constipation 38.44 9.91 1687 375356 200256 55714768
Interstitial lung disease 38.02 9.91 225 376818 56838 55858186
Forced expiratory flow decreased 37.94 9.91 16 377027 69 55914955
Spirometry abnormal 37.77 9.91 22 377021 211 55914813
Cerebral haemorrhage 37.53 9.91 85 376958 28521 55886503
Status epilepticus 37.39 9.91 28 377015 15113 55899911
Myelodysplastic syndrome 37.20 9.91 33 377010 16373 55898651
Foot deformity 37.12 9.91 64 376979 23761 55891263
Cardiotoxicity 37.04 9.91 4 377039 7646 55907378
Disseminated intravascular coagulation 37.04 9.91 39 377004 17846 55897178
Circumstance or information capable of leading to device use error 37.00 9.91 18 377025 115 55914909
Sputum retention 36.75 9.91 29 377014 475 55914549
Blood lactate dehydrogenase increased 36.55 9.91 51 376992 20624 55894400
Bronchial neoplasm 36.45 9.91 28 377015 440 55914584
Acute myeloid leukaemia 36.29 9.91 36 377007 16936 55898088
Idiopathic intracranial hypertension 36.24 9.91 63 376980 2491 55912533
Pruritus 36.16 9.91 2523 374520 314100 55600924
Musculoskeletal pain 36.10 9.91 358 376685 80794 55834230
Frustration tolerance decreased 36.09 9.91 109 376934 6244 55908780
Animal scratch 36.01 9.91 40 377003 1028 55913996
Hyper IgE syndrome 35.97 9.91 27 377016 409 55914615
Multiple drug therapy 35.94 9.91 66 376977 2726 55912298
Device ineffective 35.88 9.91 20 377023 175 55914849
Feeling abnormal 35.72 9.91 1159 375884 132443 55782581
Forced expiratory volume abnormal 35.70 9.91 15 377028 64 55914960
Intentional self-injury 35.51 9.91 71 376972 24921 55890103
Infection 35.49 9.91 1045 375998 199161 55715863
Cardiac disorder 35.33 9.91 466 376577 45421 55869603
Poisoning 35.26 9.91 21 377022 12792 55902232
Neuropathy peripheral 35.25 9.91 481 376562 102412 55812612
COVID-19 35.16 9.91 702 376341 74356 55840668
Respiratory failure 35.00 9.91 859 376184 94203 55820821
Device information output issue 34.81 9.91 15 377028 69 55914955
Hypothyroidism 34.64 9.91 400 376643 37796 55877228
Urinary tract discomfort 34.61 9.91 24 377019 319 55914705
Bronchial haemorrhage 34.20 9.91 29 377014 528 55914496
Immunodeficiency 34.20 9.91 205 376838 15952 55899072
Somnolence 34.18 9.91 833 376210 162580 55752444
Nausea 34.08 9.91 4543 372500 759635 55155389
Transplant rejection 33.99 9.91 12 377031 9922 55905102
Exposure to allergen 33.63 9.91 21 377022 231 55914793
Joint range of motion decreased 33.58 9.91 75 376968 25290 55889734
Broncholithiasis 33.38 9.91 20 377023 203 55914821
Infusion site erythema 33.19 9.91 140 376903 9466 55905558
Sinusitis fungal 32.86 9.91 46 376997 1504 55913520
Thrombotic microangiopathy 32.84 9.91 11 377032 9400 55905624
Ulcer 32.71 9.91 63 376980 22422 55892602
Infusion site swelling 32.65 9.91 122 376921 7799 55907225
Progressive multifocal leukoencephalopathy 32.63 9.91 20 377023 11993 55903031
Embolism venous 32.55 9.91 64 376979 2784 55912240
Hereditary angioedema 32.21 9.91 110 376933 6725 55908299
Breath alcohol test positive 32.10 9.91 8 377035 0 55915024
Pulmonary congestion 31.92 9.91 201 376842 15914 55899110
Renal failure 31.87 9.91 534 376509 109966 55805058
Injection site reaction 31.86 9.91 217 376826 53030 55861994
Sputum culture positive 31.62 9.91 48 376995 1691 55913333
Blood pressure increased 31.55 9.91 1230 375813 143946 55771078
Alveolar osteitis 31.40 9.91 28 377015 547 55914477
Lymphopenia 31.05 9.91 40 377003 16734 55898290
Rash maculo-papular 30.99 9.91 95 376948 28812 55886212
Rubber sensitivity 30.96 9.91 51 376992 1929 55913095
Aspirin-exacerbated respiratory disease 30.94 9.91 34 377009 863 55914161
Rash erythematous 30.77 9.91 383 376660 36838 55878186
Salpingo-oophorectomy unilateral 30.66 9.91 30 377013 662 55914362
Device expulsion 30.60 9.91 103 376940 30346 55884678
Hypercapnia 30.43 9.91 89 376954 5007 55910017
Gamma-glutamyltransferase increased 30.40 9.91 106 376937 30899 55884125
Ventricular failure 30.39 9.91 23 377020 353 55914671
Lymph node calcification 30.35 9.91 21 377022 278 55914746
Acute hepatic failure 30.21 9.91 40 377003 16538 55898486
Bradycardia 29.94 9.91 298 376745 67206 55847818
Sinus congestion 29.84 9.91 194 376849 15530 55899494
Respiratory gas exchange disorder 29.83 9.91 22 377021 324 55914700
Sinus operation 29.69 9.91 51 376992 1997 55913027
Tubulointerstitial nephritis 29.57 9.91 41 377002 16624 55898400
Distal intestinal obstruction syndrome 29.54 9.91 23 377020 369 55914655
Breast cancer stage III 29.51 9.91 6 377037 7157 55907867
Diarrhoea 29.49 9.91 3787 373256 634720 55280304
Rebound nasal congestion 29.27 9.91 10 377033 20 55915004
Drug dependence 29.16 9.91 254 376789 22279 55892745
Extrapyramidal disorder 29.06 9.91 24 377019 12332 55902692
Migraine 28.93 9.91 774 376269 86023 55829001
Blood creatinine increased 28.88 9.91 371 376672 79820 55835204
Grip strength decreased 28.83 9.91 40 377003 16216 55898808
Hypertensive crisis 28.63 9.91 31 377012 14005 55901019
Foreign body in reproductive tract 28.52 9.91 25 377018 477 55914547
Breast cancer metastatic 28.52 9.91 37 377006 15432 55899592
Drug level increased 28.50 9.91 60 376983 20665 55894359
Hepatic cytolysis 28.47 9.91 19 377024 10887 55904137
Ascites 28.33 9.91 142 376901 37402 55877622
Nicotine dependence 28.26 9.91 29 377014 679 55914345
Febrile bone marrow aplasia 28.15 9.91 5 377038 6567 55908457
Sinus tachycardia 28.01 9.91 251 376792 22193 55892831
Plasma cell myeloma 27.95 9.91 190 376853 46456 55868568
Pulmonary toxicity 27.88 9.91 9 377034 7874 55907150
Stress cardiomyopathy 27.65 9.91 120 376923 8216 55906808
Skin candida 27.49 9.91 40 377003 1356 55913668
Adverse event 27.34 9.91 238 376805 55138 55859886
Limb injury 27.26 9.91 248 376795 22022 55893002
Exercise tolerance decreased 27.18 9.91 86 376957 5052 55909972
Enthesopathy 27.14 9.91 10 377033 8053 55906971
Respiratory tract irritation 27.11 9.91 23 377020 419 55914605
Ill-defined disorder 27.00 9.91 311 376732 68232 55846792
Cardiac failure 26.97 9.91 387 376656 81706 55833318
Hypercalcaemia 26.89 9.91 84 376959 25327 55889697
Uveitis 26.78 9.91 21 377022 11074 55903950
Psoriasis 26.71 9.91 448 376595 92244 55822780
Expired product administered 26.27 9.91 90 376953 5512 55909512
Hepatic failure 26.22 9.91 125 376918 33361 55881663
Bronchitis bacterial 26.21 9.91 29 377014 742 55914282
Device deposit issue 26.13 9.91 8 377035 9 55915015
Live birth 25.93 9.91 58 376985 19547 55895477
Haemophagocytic lymphohistiocytosis 25.91 9.91 16 377027 9556 55905468
Rhinovirus infection 25.87 9.91 71 376972 3851 55911173
Generalised tonic-clonic seizure 25.86 9.91 96 376947 27470 55887554
Hyposmia 25.81 9.91 26 377017 595 55914429
Nephrectomy 25.72 9.91 36 377007 1177 55913847
Graft versus host disease 25.33 9.91 7 377036 6774 55908250
Encephalopathy 25.31 9.91 136 376907 35189 55879835
Tuberculosis 25.23 9.91 22 377021 11007 55904017
FEV1/FVC ratio decreased 25.15 9.91 12 377031 73 55914951
Rectal prolapse 25.01 9.91 45 376998 1829 55913195
Pain 24.97 9.91 3982 373061 659202 55255822
Macular degeneration 24.95 9.91 56 376987 18852 55896172
Pregnancy 24.89 9.91 125 376918 32908 55882116
Paraesthesia oral 24.86 9.91 174 376869 14275 55900749
Diffuse large B-cell lymphoma 24.83 9.91 8 377035 7008 55908016
Nasal inflammation 24.79 9.91 22 377021 427 55914597
Chronic respiratory failure 24.69 9.91 43 377000 1703 55913321
Skin necrosis 24.44 9.91 28 377015 12333 55902691
Chills 24.37 9.91 878 376165 101726 55813298
Vocal cord disorder 24.32 9.91 37 377006 1306 55913718
Polyneuropathy 24.28 9.91 31 377012 13019 55902005
Intentional device misuse 24.15 9.91 27 377016 699 55914325
Fracture 24.08 9.91 53 376990 17965 55897059
Joint stiffness 23.96 9.91 139 376904 35286 55879738
Herpes zoster 23.80 9.91 361 376682 75528 55839496
Bacterial disease carrier 23.67 9.91 30 377013 889 55914135
Rib deformity 23.57 9.91 16 377027 205 55914819
Haemoglobin decreased 23.54 9.91 701 376342 133436 55781588
Painful respiration 23.47 9.91 52 376991 2462 55912562
Anosmia 23.41 9.91 74 376969 4345 55910679
Chest X-ray abnormal 23.28 9.91 70 376973 4000 55911024
Pyrexia 23.23 9.91 2453 374590 416320 55498704
Proteinuria 23.22 9.91 52 376991 17518 55897506
Seizure 23.18 9.91 649 376394 124470 55790554
Accidental exposure to product 23.01 9.91 86 376957 24561 55890463
Unintentional medical device removal 22.98 9.91 5 377038 5689 55909335
Oesophageal spasm 22.91 9.91 55 376988 2747 55912277
Choking sensation 22.90 9.91 61 376982 3250 55911774
Pharyngeal oedema 22.87 9.91 160 376883 13125 55901899
Depressed mood 22.72 9.91 356 376687 36003 55879021
Liver disorder 22.66 9.91 189 376854 44181 55870843
Endometrial ablation 22.46 9.91 29 377014 876 55914148
Gallbladder injury 22.40 9.91 35 377008 1265 55913759
Metastases to central nervous system 22.40 9.91 29 377014 12107 55902917
Tunnel vision 22.38 9.91 28 377015 819 55914205
Sarcoidosis 22.25 9.91 84 376959 5396 55909628
Breast cancer female 22.25 9.91 30 377013 12308 55902716
Asthma exercise induced 22.19 9.91 17 377026 266 55914758
Nasal pruritus 22.14 9.91 19 377024 352 55914672
Cardiac arrest 22.08 9.91 426 376617 85888 55829136
Nasal septum deviation 22.02 9.91 35 377008 1284 55913740
Haemorrhage intracranial 22.01 9.91 32 377011 12723 55902301
Crepitations 22.00 9.91 99 376944 6885 55908139
Airway remodelling 21.93 9.91 10 377033 54 55914970
Angioedema 21.92 9.91 395 376648 41058 55873966
Foreign body aspiration 21.91 9.91 15 377028 195 55914829
Aphthous ulcer 21.90 9.91 29 377014 11990 55903034
Breast cancer 21.89 9.91 215 376828 48618 55866406
Toxic skin eruption 21.72 9.91 28 377015 11711 55903313
Tracheomalacia 21.70 9.91 13 377030 132 55914892
Urosepsis 21.66 9.91 50 376993 16666 55898358
Deformity 21.64 9.91 22 377021 10233 55904791
Colitis ulcerative 21.56 9.91 87 376956 24304 55890720
Joint destruction 21.32 9.91 4 377039 5051 55909973
Respiratory tract infection viral 21.28 9.91 43 377000 1908 55913116
Myalgia 21.28 9.91 1085 375958 130940 55784084
Sputum abnormal 21.27 9.91 22 377021 520 55914504
Peripheral sensory neuropathy 21.21 9.91 10 377033 6946 55908078
Separation anxiety disorder 21.17 9.91 8 377035 24 55915000
Bronchomalacia 21.16 9.91 15 377028 207 55914817
Cytokine release syndrome 21.11 9.91 25 377018 10850 55904174
Therapy partial responder 21.09 9.91 13 377030 7772 55907252
Thunderclap headache 21.05 9.91 14 377029 173 55914851
Bradyphrenia 20.99 9.91 9 377034 6611 55908413
Hypoalbuminaemia 20.97 9.91 24 377019 10575 55904449
Colitis 20.95 9.91 179 376864 41632 55873392
Blood insulin abnormal 20.93 9.91 8 377035 25 55914999
Malignant mediastinal neoplasm 20.91 9.91 28 377015 877 55914147
Pulmonary pain 20.88 9.91 54 376989 2826 55912198
Lupus-like syndrome 20.65 9.91 32 377011 12395 55902629
Device defective 20.61 9.91 37 377006 1501 55913523
Ischaemic stroke 20.54 9.91 52 376991 16790 55898234
Blood iron decreased 20.53 9.91 150 376893 12477 55902547
Breast cancer stage I 20.52 9.91 8 377035 6222 55908802
Obstruction 20.48 9.91 48 376995 2360 55912664
Enterocolitis 20.47 9.91 11 377032 7093 55907931
Osteomyelitis 20.18 9.91 89 376954 24257 55890767
Nasal oedema 20.11 9.91 31 377012 1107 55913917
Akathisia 20.11 9.91 17 377026 8635 55906389
Drug ineffective for unapproved indication 20.07 9.91 96 376947 25597 55889427
Nervousness 20.03 9.91 289 376754 28726 55886298
Cardiac murmur 20.03 9.91 138 376905 11263 55903761
Adverse drug reaction 20.02 9.91 311 376732 64821 55850203
Nystagmus 19.99 9.91 7 377036 5818 55909206
Dermatitis allergic 19.91 9.91 161 376882 13817 55901207
Pre-existing condition improved 19.77 9.91 100 376943 7298 55907726
Occupational asthma 19.69 9.91 12 377031 126 55914898
Tongue pruritus 19.63 9.91 20 377023 464 55914560
Breast cancer stage II 19.62 9.91 7 377036 5751 55909273
Bronchitis chronic 19.52 9.91 65 376978 3923 55911101
Pneumonia aspiration 19.43 9.91 132 376911 32279 55882745
Cervix neoplasm 19.28 9.91 14 377029 201 55914823
Hypertransaminasaemia 19.27 9.91 4 377039 4703 55910321
Neutrophilia 19.16 9.91 64 376979 3869 55911155
Exostosis 19.12 9.91 45 376998 14898 55900126
Magnetic resonance imaging thoracic abnormal 19.03 9.91 7 377036 19 55915005
Cardiac failure congestive 18.99 9.91 743 376300 86977 55828047
Soft tissue disorder 18.91 9.91 3 377040 4279 55910745
Transaminases increased 18.87 9.91 114 376929 28656 55886368
Hyperhidrosis 18.77 9.91 790 376253 93298 55821726
Inappropriate antidiuretic hormone secretion 18.77 9.91 40 377003 13716 55901308
Cockroach allergy 18.70 9.91 9 377034 56 55914968
Ejection fraction decreased 18.67 9.91 69 376974 19772 55895252
Oropharyngeal discomfort 18.57 9.91 69 376974 4399 55910625
Retinitis 18.56 9.91 3 377040 4221 55910803
Pneumonia pseudomonal 18.55 9.91 44 376999 2180 55912844
Body temperature abnormal 18.55 9.91 36 377007 1551 55913473
Pharyngitis streptococcal 18.52 9.91 118 376925 9380 55905644
Oxygen consumption increased 18.50 9.91 60 376983 3571 55911453
Mouth swelling 18.50 9.91 65 376978 4032 55910992
Bronchiolitis 18.47 9.91 47 376996 2435 55912589
Shock haemorrhagic 18.37 9.91 20 377023 9013 55906011
Oropharyngitis fungal 18.36 9.91 8 377035 38 55914986
Stress urinary incontinence 18.33 9.91 43 377000 2115 55912909
Respiratory arrest 18.22 9.91 125 376918 30500 55884524
PCO2 increased 18.15 9.91 30 377013 1138 55913886
Basal cell carcinoma 18.12 9.91 97 376946 25124 55889900
Ejection fraction abnormal 18.10 9.91 29 377014 1071 55913953
Enteritis 18.07 9.91 14 377029 7429 55907595
Hepatic cirrhosis 18.07 9.91 77 376966 21186 55893838
Electrocardiogram QRS complex prolonged 18.04 9.91 7 377036 5460 55909564
Suspected suicide 18.03 9.91 7 377036 5459 55909565
Haemolytic anaemia 18.02 9.91 23 377020 9662 55905362
Multiple sclerosis relapse 17.97 9.91 203 376840 44700 55870324
Decreased bronchial secretion 17.94 9.91 9 377034 62 55914962
Sinonasal obstruction 17.91 9.91 14 377029 226 55914798
Cytomegalovirus viraemia 17.84 9.91 6 377037 5114 55909910
Tobacco abuse 17.83 9.91 22 377021 634 55914390
Suspected COVID-19 17.81 9.91 41 377002 1992 55913032
Metastases to lung 17.78 9.91 32 377011 11686 55903338
Brain oedema 17.76 9.91 39 377004 13232 55901792
Nocturnal dyspnoea 17.68 9.91 28 377015 1024 55914000
Heart sounds 17.56 9.91 24 377019 767 55914257
Biliary dyskinesia 17.51 9.91 47 376996 2516 55912508
Bone density decreased 17.49 9.91 37 377006 12723 55902301
Essential hypertension 17.48 9.91 70 376973 4623 55910401
Deep vein thrombosis postoperative 17.47 9.91 3 377040 4038 55910986
Uterine perforation 17.43 9.91 88 376955 6417 55908607
Rhabdomyolysis 17.40 9.91 181 376862 40477 55874547
Carpal tunnel syndrome 17.35 9.91 192 376851 17952 55897072
Influenza like illness 17.32 9.91 533 376510 60455 55854569
Stress 17.31 9.91 517 376526 58393 55856631
Nasal disorder 17.29 9.91 47 376996 2535 55912489
Allergic cough 17.26 9.91 20 377023 539 55914485
Functional residual capacity increased 17.25 9.91 9 377034 68 55914956
Peak expiratory flow rate abnormal 17.25 9.91 10 377033 95 55914929
Intentional product misuse 17.19 9.91 242 376801 51262 55863762
Panic attack 17.16 9.91 211 376832 20236 55894788
Venous pressure jugular increased 17.14 9.91 20 377023 543 55914481
Musculoskeletal disorder 17.11 9.91 68 376975 19079 55895945
Ear congestion 17.04 9.91 42 377001 2133 55912891
Erysipelas 16.97 9.91 14 377029 7199 55907825
Ear discomfort 16.97 9.91 93 376950 7002 55908022
Use of accessory respiratory muscles 16.96 9.91 12 377031 165 55914859
Red cell distribution width abnormal 16.95 9.91 11 377032 130 55914894
Dizziness 16.93 9.91 2816 374227 373324 55541700
Purpura 16.92 9.91 27 377016 10335 55904689
Pneumonia respiratory syncytial viral 16.90 9.91 22 377021 670 55914354
Sleep terror 16.87 9.91 23 377020 733 55914291
Bacterial infection 16.85 9.91 184 376859 17146 55897878
Neuroleptic malignant syndrome 16.83 9.91 32 377011 11446 55903578
Muscle spasms 16.76 9.91 1101 375942 136270 55778754
Increased viscosity of bronchial secretion 16.69 9.91 14 377029 251 55914773
Candida infection 16.68 9.91 253 376790 25414 55889610
Infusion site urticaria 16.64 9.91 30 377013 1221 55913803
Disorientation 16.49 9.91 161 376882 36452 55878572
Skin ulcer 16.47 9.91 172 376871 38436 55876588
Neurosensory hypoacusis 16.42 9.91 13 377030 214 55914810
Functional residual capacity decreased 16.41 9.91 9 377034 76 55914948
Pemphigoid 16.41 9.91 11 377032 6289 55908735
Oral pruritus 16.35 9.91 37 377006 1777 55913247
Pathogen resistance 16.28 9.91 10 377033 5990 55909034
Respiratory acidosis 16.26 9.91 83 376960 6080 55908944
Duodenal ulcer repair 16.21 9.91 8 377035 53 55914971
Thyroid atrophy 16.13 9.91 6 377037 17 55915007
Pneumonectomy 16.05 9.91 4 377039 0 55915024
Carbon dioxide increased 15.96 9.91 29 377014 1188 55913836
Bacterial tracheitis 15.88 9.91 6 377037 18 55915006
Symptom recurrence 15.85 9.91 27 377016 1050 55913974
Dehydration 15.81 9.91 886 376157 157939 55757085
Infusion site pruritus 15.79 9.91 69 376974 4738 55910286
Pulmonary thrombosis 15.77 9.91 100 376943 7937 55907087
Epstein-Barr virus infection 15.76 9.91 16 377027 7447 55907577
Nasal mucosal discolouration 15.73 9.91 5 377038 7 55915017
Lip discolouration 15.72 9.91 19 377024 536 55914488
Oesophageal pain 15.69 9.91 53 376990 3222 55911802
Hepatitis cholestatic 15.66 9.91 12 377031 6402 55908622
Breast cancer recurrent 15.61 9.91 4 377039 4071 55910953
Nightmare 15.61 9.91 177 376866 16649 55898375
Diastolic dysfunction 15.58 9.91 77 376966 5568 55909456
Labelled drug-drug interaction medication error 15.55 9.91 34 377009 11552 55903472
Impaired work ability 15.54 9.91 48 376995 14524 55900500
Oesophagogastroduodenoscopy 15.49 9.91 10 377033 117 55914907
Hyperbilirubinaemia 15.48 9.91 28 377015 10207 55904817
Sinus headache 15.41 9.91 70 376973 4888 55910136
Tremor 15.41 9.91 974 376069 120115 55794909
Pneumothorax spontaneous 15.29 9.91 22 377021 738 55914286
Aplasia pure red cell 15.28 9.91 5 377038 4337 55910687
Ovarian hyperstimulation syndrome 15.24 9.91 3 377040 3661 55911363
Hyperprolactinaemia 15.22 9.91 3 377040 3658 55911366
Gait disturbance 15.19 9.91 917 376126 162404 55752620
Aplasia 15.16 9.91 4 377039 3992 55911032
Alanine aminotransferase abnormal 15.13 9.91 5 377038 4310 55910714
Anhedonia 15.12 9.91 116 376927 9798 55905226
Dyspnoea at rest 15.11 9.91 58 376985 3755 55911269
Psychotic disorder 15.11 9.91 94 376949 23464 55891560
Lung operation 15.08 9.91 12 377031 199 55914825
Self-injurious ideation 14.96 9.91 42 377001 2308 55912716
Oxygen therapy 14.92 9.91 37 377006 1886 55913138
Crystal arthropathy 14.92 9.91 13 377030 246 55914778
Therapeutic response decreased 14.87 9.91 256 376787 52502 55862522
Postural orthostatic tachycardia syndrome 14.87 9.91 25 377018 962 55914062
Aplastic anaemia 14.83 9.91 23 377020 8905 55906119
Product prescribing issue 14.80 9.91 36 377007 1813 55913211
Infusion site extravasation 14.79 9.91 100 376943 8110 55906914
Eye swelling 14.79 9.91 213 376830 21163 55893861
Injection site scab 14.75 9.91 16 377027 400 55914624
Subdural haematoma 14.73 9.91 44 376999 13455 55901569
Osteonecrosis 14.70 9.91 93 376950 23122 55891902
Immune reconstitution inflammatory syndrome 14.65 9.91 10 377033 5664 55909360
Facet joint syndrome 14.65 9.91 14 377029 6703 55908321
Small airways disease 14.64 9.91 5 377038 10 55915014
Crying 14.58 9.91 213 376830 21227 55893797
Tumour lysis syndrome 14.55 9.91 19 377024 7904 55907120
Central obesity 14.55 9.91 27 377016 1124 55913900
Metastases to lymph nodes 14.48 9.91 17 377026 7406 55907618
Blood bilirubin increased 14.47 9.91 148 376895 33206 55881818
Delirium 14.47 9.91 199 376844 42318 55872706
Gastrointestinal toxicity 14.42 9.91 12 377031 6144 55908880
Incorrect dose administered by device 14.41 9.91 57 376986 3743 55911281
Pneumococcal infection 14.41 9.91 16 377027 411 55914613
Influenza B virus test positive 14.37 9.91 13 377030 259 55914765
Factitious disorder 14.35 9.91 8 377035 70 55914954
Juvenile idiopathic arthritis 14.34 9.91 7 377036 4766 55910258
Endometriosis 14.33 9.91 66 376977 4636 55910388
Forced expiratory volume increased 14.32 9.91 5 377038 11 55915013
Retching 14.25 9.91 146 376897 13384 55901640
Skin toxicity 14.24 9.91 5 377038 4148 55910876
Deep vein thrombosis 14.17 9.91 641 376402 76336 55838688
Nephropathy toxic 14.13 9.91 22 377021 8505 55906519
Lung consolidation 14.11 9.91 58 376985 3876 55911148
Abortion spontaneous 14.10 9.91 207 376836 43546 55871478
Red blood cell count decreased 14.09 9.91 167 376876 36450 55878574
Allergic sinusitis 14.08 9.91 20 377023 663 55914361
PO2 decreased 14.08 9.91 30 377013 1383 55913641
Jaundice 14.05 9.91 116 376927 27178 55887846
Eosinophilic pneumonia chronic 14.05 9.91 11 377032 178 55914846
Tenosynovitis 14.05 9.91 40 377003 12421 55902603
Pickwickian syndrome 14.02 9.91 14 377029 317 55914707
CFTR gene mutation 13.97 9.91 9 377034 105 55914919
Tricuspid valve incompetence 13.96 9.91 143 376900 13110 55901914
Colorectal cancer 13.86 9.91 3 377040 3426 55911598
Oxygen consumption decreased 13.86 9.91 12 377031 225 55914799
Administration site inflammation 13.83 9.91 4 377039 3 55915021
Obstructive pancreatitis 13.80 9.91 15 377028 376 55914648
Inappropriate schedule of product administration 13.78 9.91 687 376356 82700 55832324
Muscle rigidity 13.76 9.91 32 377011 10639 55904385
Hyperammonaemia 13.73 9.91 8 377035 4932 55910092
Ataxia 13.61 9.91 50 376993 14353 55900671
Hypervolaemia 13.59 9.91 251 376792 26207 55888817
Blood electrolytes abnormal 13.57 9.91 24 377019 962 55914062
Peritonitis 13.57 9.91 59 376984 16143 55898881
Kyphosis 13.55 9.91 40 377003 2262 55912762
Scleritis 13.55 9.91 4 377039 3707 55911317
Nasal turbinate abnormality 13.53 9.91 6 377037 30 55914994
Blood lactic acid increased 13.52 9.91 78 376965 5986 55909038
Arthritis bacterial 13.50 9.91 12 377031 5949 55909075
Atopy 13.43 9.91 12 377031 235 55914789
Oesophageal dilatation 13.43 9.91 14 377029 334 55914690
Laryngeal pain 13.43 9.91 60 376983 4160 55910864
Breast conserving surgery 13.40 9.91 23 377020 900 55914124
Varicella zoster gastritis 13.37 9.91 6 377037 31 55914993
Colitis microscopic 13.35 9.91 20 377023 7855 55907169
Psychomotor retardation 13.31 9.91 4 377039 3665 55911359
Stevens-Johnson syndrome 13.24 9.91 93 376950 22570 55892454
Radioallergosorbent test positive 13.22 9.91 6 377037 32 55914992
Cor pulmonale 13.20 9.91 36 377007 1945 55913079
Depressed level of consciousness 13.17 9.91 482 376561 55951 55859073
Hypocalcaemia 13.15 9.91 126 376917 28634 55886390
Cystic fibrosis lung 13.15 9.91 9 377034 117 55914907
Malignant melanoma 13.15 9.91 33 377010 10686 55904338
Carbon dioxide abnormal 13.13 9.91 10 377033 155 55914869
Body mass index increased 13.11 9.91 25 377018 1063 55913961
Premature delivery 13.04 9.91 117 376926 26943 55888081
Neuromyotonia 12.98 9.91 7 377036 57 55914967
Cholecystectomy 12.97 9.91 110 376933 9574 55905450
Diastolic hypotension 12.97 9.91 8 377035 86 55914938
Stridor 12.96 9.91 50 376993 3245 55911779
Metastasis 12.94 9.91 8 377035 4776 55910248
Kidney transplant rejection 12.93 9.91 6 377037 4207 55910817
Blood potassium decreased 12.92 9.91 345 376698 38327 55876697
Atypical fracture 12.92 9.91 18 377025 586 55914438
Wolff-Parkinson-White syndrome 12.89 9.91 9 377034 121 55914903
Administration site erythema 12.89 9.91 18 377025 587 55914437
Mydriasis 12.88 9.91 35 377008 11036 55903988
Klebsiella infection 12.86 9.91 20 377023 7736 55907288
Ileus paralytic 12.84 9.91 6 377037 4189 55910835
Mucosal discolouration 12.81 9.91 16 377027 467 55914557
Overweight 12.80 9.91 50 376993 3264 55911760
Red blood cell sedimentation rate abnormal 12.77 9.91 73 376970 18600 55896424
Nasal flaring 12.77 9.91 5 377038 17 55915007
Upper airway obstruction 12.76 9.91 18 377025 593 55914431
Lip dry 12.73 9.91 29 377014 9711 55905313
Hyperkalaemia 12.71 9.91 252 376791 50613 55864411
Bronchoscopy 12.68 9.91 7 377036 60 55914964
Generalised anxiety disorder 12.63 9.91 35 377008 1909 55913115
Oral candidiasis 12.60 9.91 186 376857 18577 55896447
Lactose intolerance 12.59 9.91 43 377000 2629 55912395
Demyelination 12.58 9.91 14 377029 6248 55908776
Liver function test increased 12.55 9.91 124 376919 28009 55887015
Excessive eye blinking 12.51 9.91 24 377019 1025 55913999
Lipohypertrophy 12.46 9.91 18 377025 606 55914418
Pharyngeal erythema 12.46 9.91 31 377012 1584 55913440
Product availability issue 12.43 9.91 47 376996 3022 55912002
Tachypnoea 12.42 9.91 158 376885 15272 55899752
Respiratory syncytial virus bronchiolitis 12.41 9.91 13 377030 312 55914712
Gastroenteritis viral 12.39 9.91 199 376844 20225 55894799
Rib fracture 12.36 9.91 198 376845 20111 55894913
Product administration error 12.35 9.91 203 376840 20726 55894298
Peripheral vascular disorder 12.35 9.91 73 376970 5652 55909372
Paranoia 12.32 9.91 118 376925 10626 55904398
Injection site erythema 12.31 9.91 410 376633 77038 55837986
Appetite disorder 12.30 9.91 81 376962 6512 55908512
Poor quality product administered 12.24 9.91 45 376998 2854 55912170
Cerebellar syndrome 12.19 9.91 4 377039 3463 55911561
Hyperventilation 12.17 9.91 72 376971 5576 55909448
Dislocation of vertebra 12.15 9.91 11 377032 5404 55909620
Sinus polyp 12.11 9.91 13 377030 321 55914703
X-ray abnormal 12.11 9.91 7 377036 4334 55910690
Trifascicular block 12.09 9.91 8 377035 98 55914926
Spinal pain 12.08 9.91 40 377003 11844 55903180
Noninfective bronchitis 12.04 9.91 3 377040 0 55915024
Weight 12.04 9.91 3 377040 0 55915024
Inspiratory capacity decreased 12.03 9.91 7 377036 67 55914957
Acute sinusitis 11.98 9.91 52 376991 3561 55911463
Blood pressure fluctuation 11.97 9.91 194 376849 40166 55874858
Weight decreased 11.94 9.91 1812 375231 238902 55676122
Cystic fibrosis related diabetes 11.76 9.91 6 377037 43 55914981
BK virus infection 11.75 9.91 3 377040 3061 55911963
Blood iron abnormal 11.69 9.91 4 377039 3373 55911651
Mycobacterium avium complex infection 11.67 9.91 44 376999 2825 55912199
Sepsis 11.65 9.91 793 376250 139047 55775977
Airway peak pressure increased 11.62 9.91 12 377031 283 55914741
Cardiogenic shock 11.61 9.91 63 376980 16262 55898762
Adverse reaction 11.58 9.91 29 377014 9398 55905626
Breath sounds 11.56 9.91 8 377035 106 55914918
Croup infectious 11.52 9.91 15 377028 457 55914567
Pulmonary oedema 11.49 9.91 435 376608 50708 55864316
Paranasal sinus hypersecretion 11.49 9.91 48 376995 3232 55911792
Pneumothorax 11.45 9.91 151 376892 14716 55900308
Product expiration date issue 11.40 9.91 4 377039 9 55915015
Haemophilus infection 11.35 9.91 24 377019 1100 55913924
Product label issue 11.33 9.91 18 377025 660 55914364
Angle closure glaucoma 11.27 9.91 35 377008 2036 55912988
Loss of consciousness 11.24 9.91 608 376435 108741 55806283
Decreased activity 11.21 9.91 70 376973 5526 55909498
Weight fluctuation 11.18 9.91 92 376951 7936 55907088
Tobacco user 11.17 9.91 19 377024 738 55914286
Oliguria 11.13 9.91 25 377018 8415 55906609
Sweating fever 11.12 9.91 5 377038 26 55914998
Infusion site pain 11.11 9.91 141 376902 13621 55901403
Blood magnesium increased 11.11 9.91 3 377040 2948 55912076
Supraventricular tachycardia 11.09 9.91 137 376906 13154 55901870
Intestinal perforation 11.06 9.91 37 377006 10922 55904102
Graft versus host disease in gastrointestinal tract 11.04 9.91 3 377040 2936 55912088
Subarachnoid haemorrhage 10.98 9.91 39 377004 11308 55903716
Reversible cerebral vasoconstriction syndrome 10.98 9.91 38 377005 2339 55912685
Pulmonary hypertension 10.98 9.91 317 376726 35627 55879397
Acute respiratory distress syndrome 10.92 9.91 94 376949 21832 55893192
Contusion 10.92 9.91 727 376316 127703 55787321
Upper respiratory tract congestion 10.90 9.91 33 377010 1893 55913131
Vision blurred 10.88 9.91 669 376374 82274 55832750
Mania 10.88 9.91 40 377003 11480 55903544
Secondary immunodeficiency 10.86 9.91 25 377018 1215 55913809
Product prescribing error 10.85 9.91 101 376942 23085 55891939
Infusion site mass 10.84 9.91 28 377015 1464 55913560
Coagulopathy 10.83 9.91 77 376966 18639 55896385
Ketoacidosis 10.77 9.91 7 377036 4068 55910956
Respiratory syncytial virus infection 10.74 9.91 68 376975 5393 55909631
Dyspnoea paroxysmal nocturnal 10.72 9.91 20 377023 836 55914188
Adjustment disorder with depressed mood 10.71 9.91 11 377032 5092 55909932
Infusion site rash 10.68 9.91 29 377014 1563 55913461
Bursitis 10.68 9.91 251 376792 27331 55887693
Blood alkaline phosphatase increased 10.64 9.91 190 376853 38755 55876269
Pathological fracture 10.64 9.91 24 377019 8065 55906959
Activated partial thromboplastin time 10.59 9.91 4 377039 12 55915012
Tympanoplasty 10.59 9.91 4 377039 12 55915012
Forced expiratory volume 10.59 9.91 4 377039 12 55915012
Heart block congenital 10.59 9.91 4 377039 12 55915012
Orthopnoea 10.58 9.91 71 376972 5745 55909279
Blood creatine phosphokinase increased 10.55 9.91 128 376915 27824 55887200
Infusion site bruising 10.54 9.91 42 377001 2767 55912257
Lower limb fracture 10.53 9.91 72 376971 17583 55897441
Escherichia bacteraemia 10.51 9.91 5 377038 3455 55911569
Micturition disorder 10.49 9.91 36 377007 2207 55912817
Ventricular arrhythmia 10.48 9.91 5 377038 3449 55911575
Body temperature decreased 10.45 9.91 175 376868 17933 55897091
Nasal cyst 10.44 9.91 6 377037 56 55914968
Eosinophilic oesophagitis 10.43 9.91 11 377032 266 55914758
Caesarean section 10.42 9.91 64 376979 16027 55898997
Drug administered in wrong device 10.40 9.91 5 377038 31 55914993
Ankylosing spondylitis 10.38 9.91 33 377010 9897 55905127
Vertigo 10.38 9.91 282 376761 54290 55860734
Adjusted calcium decreased 10.34 9.91 9 377034 170 55914854
Incorrect dose administered by product 10.30 9.91 9 377034 171 55914853
Lower respiratory tract infection bacterial 10.29 9.91 13 377030 384 55914640
Asthma late onset 10.27 9.91 5 377038 32 55914992
Femoral neck fracture 10.27 9.91 23 377020 7748 55907276
PCO2 abnormal 10.26 9.91 6 377037 58 55914966
Burns third degree 10.24 9.91 11 377032 272 55914752
Peripheral venous disease 10.19 9.91 34 377009 10045 55904979
Gallbladder disorder 10.18 9.91 168 376875 17166 55897858
Infective exacerbation of bronchiectasis 10.14 9.91 12 377031 331 55914693
Mucormycosis 10.11 9.91 3 377040 2771 55912253
Product packaging quantity issue 10.11 9.91 24 377019 1190 55913834
Gingival bleeding 10.07 9.91 42 377001 11624 55903400
Gingivitis 10.04 9.91 23 377020 7686 55907338
Cachexia 9.98 9.91 11 377032 4931 55910093
Allergy to surgical sutures 9.98 9.91 3 377040 3 55915021
Right ventricular systolic pressure 9.98 9.91 3 377040 3 55915021
Diabetes mellitus inadequate control 9.95 9.91 140 376903 13840 55901184
Polymyalgia rheumatica 9.94 9.91 44 376999 3038 55911986
Neutropenic colitis 9.94 9.91 3 377040 2740 55912284
Skin laceration 9.94 9.91 190 376853 19966 55895058

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 5355.59 10.77 3292 189693 39319 31465040
Wheezing 2471.94 10.77 1919 191066 34067 31470292
Dyspnoea 1691.59 10.77 5241 187744 338238 31166121
Chronic obstructive pulmonary disease 1361.26 10.77 1522 191463 43644 31460715
Obstructive airways disorder 1089.54 10.77 774 192211 11890 31492469
Product quality issue 980.46 10.77 801 192184 15310 31489049
Cough 946.73 10.77 2348 190637 132466 31371893
Sleep disorder due to a general medical condition 891.97 10.77 448 192537 3454 31500905
Full blood count abnormal 885.66 10.77 760 192225 15587 31488772
Poor quality device used 763.75 10.77 261 192724 602 31503757
Therapeutic product effect incomplete 752.11 10.77 1116 191869 42580 31461779
Productive cough 665.85 10.77 917 192068 32623 31471736
Infective pulmonary exacerbation of cystic fibrosis 631.97 10.77 428 192557 6056 31498303
Forced expiratory volume decreased 496.60 10.77 277 192708 2700 31501659
Chest discomfort 471.72 10.77 973 192012 48396 31455963
Loss of personal independence in daily activities 455.94 10.77 701 192284 27587 31476772
Sputum discoloured 408.09 10.77 335 192650 6441 31497918
Device delivery system issue 398.61 10.77 133 192852 276 31504083
Toxicity to various agents 368.12 10.77 338 192647 181149 31323210
Completed suicide 364.10 10.77 60 192925 91454 31412905
No adverse event 314.30 10.77 485 192500 19140 31485219
Bronchiectasis 287.48 10.77 289 192696 7291 31497068
Nasal congestion 269.72 10.77 462 192523 19919 31484440
Pulmonary function test decreased 266.58 10.77 218 192767 4167 31500192
Pneumonia 241.91 10.77 3106 189879 332206 31172153
Off label use 239.11 10.77 1196 191789 346078 31158281
Lower respiratory tract infection 235.58 10.77 527 192458 27710 31476649
Cystic fibrosis 228.70 10.77 145 192840 1821 31502538
Dyspnoea exertional 228.18 10.77 634 192351 38203 31466156
Product dose omission issue 223.05 10.77 1247 191738 104339 31400020
Nasal polyps 218.17 10.77 142 192843 1871 31502488
Drug abuse 214.00 10.77 135 192850 87623 31416736
Respiratory disorder 197.57 10.77 375 192610 17525 31486834
Blood immunoglobulin E increased 193.25 10.77 137 192848 2094 31502265
Drug interaction 192.97 10.77 639 192346 207904 31296455
Febrile neutropenia 190.57 10.77 279 192706 121570 31382789
Bronchitis 190.12 10.77 593 192392 38124 31466235
Neutropenia 183.13 10.77 361 192624 140003 31364356
Sinusitis 176.45 10.77 558 192427 36138 31468221
Middle insomnia 175.65 10.77 201 192784 5898 31498461
Breath sounds abnormal 167.17 10.77 193 192792 5719 31498640
Bronchospasm 161.81 10.77 248 192737 9724 31494635
Eosinophil count increased 154.42 10.77 213 192772 7578 31496781
Asthma-chronic obstructive pulmonary disease overlap syndrome 147.22 10.77 84 192901 858 31503501
Bronchopulmonary aspergillosis allergic 143.63 10.77 72 192913 552 31503807
Thrombocytopenia 139.86 10.77 426 192559 142321 31362038
Secretion discharge 139.30 10.77 161 192824 4776 31499583
Eosinophil count abnormal 137.40 10.77 55 192930 227 31504132
Anaemia 136.60 10.77 753 192232 212769 31291590
Influenza 135.41 10.77 582 192403 43743 31460616
Hepatic function abnormal 134.01 10.77 42 192943 41180 31463179
Bronchial wall thickening 122.49 10.77 81 192904 1098 31503261
Pancytopenia 122.24 10.77 215 192770 87101 31417258
Pulmonary function test abnormal 119.67 10.77 103 192882 2118 31502241
Eosinophilic granulomatosis with polyangiitis 113.94 10.77 88 192897 1543 31502816
Reversible airways obstruction 111.84 10.77 51 192934 308 31504051
Blood test abnormal 105.70 10.77 157 192828 5984 31498375
Bronchial obstruction 104.68 10.77 80 192905 1380 31502979
Nasopharyngitis 103.10 10.77 699 192286 62546 31441813
Sputum increased 102.64 10.77 93 192892 2052 31502307
Bronchial disorder 101.32 10.77 76 192909 1273 31503086
Asthmatic crisis 100.73 10.77 52 192933 427 31503932
Malignant neoplasm progression 100.49 10.77 206 192779 78792 31425567
Upper-airway cough syndrome 100.25 10.77 109 192876 3018 31501341
Dust allergy 98.76 10.77 55 192930 534 31503825
Bone marrow failure 97.58 10.77 25 192960 27983 31476376
Emphysema 97.36 10.77 186 192799 8732 31495627
Diarrhoea 96.85 10.77 1537 191448 350872 31153487
Nasal obstruction 96.47 10.77 54 192931 530 31503829
Cytomegalovirus infection 96.41 10.77 17 192968 24690 31479669
Lung consolidation 95.75 10.77 141 192844 5332 31499027
Mucosal inflammation 95.44 10.77 45 192940 34382 31469977
Platelet count decreased 94.13 10.77 350 192635 110085 31394274
Leukopenia 90.71 10.77 132 192853 57696 31446663
Bronchial secretion retention 90.51 10.77 70 192915 1230 31503129
Lung hyperinflation 89.52 10.77 59 192926 795 31503564
Vital capacity decreased 88.25 10.77 44 192941 333 31504026
Respiratory tract congestion 86.78 10.77 135 192850 5362 31498997
Haemoptysis 86.53 10.77 407 192578 31782 31472577
Intentional overdose 86.18 10.77 75 192910 41314 31463045
Obstruction 85.85 10.77 84 192901 2048 31502311
Sinus pain 84.59 10.77 52 192933 616 31503743
Rhinorrhoea 84.49 10.77 320 192665 22692 31481667
Gastrooesophageal reflux disease 82.26 10.77 416 192569 33455 31470904
Malaise 81.20 10.77 1459 191526 167052 31337307
Hospitalisation 80.27 10.77 549 192436 49258 31455101
Bronchial hyperreactivity 79.87 10.77 68 192917 1377 31502982
Drug resistance 79.68 10.77 22 192963 23431 31480928
Chronic sinusitis 79.20 10.77 75 192910 1754 31502605
White blood cell count decreased 78.44 10.77 271 192714 87127 31417232
Treatment failure 77.80 10.77 80 192905 40712 31463647
Impaired quality of life 77.12 10.77 101 192884 3415 31500944
Rheumatoid arthritis 76.09 10.77 108 192877 47701 31456658
Renal impairment 75.98 10.77 270 192715 86079 31418280
Hypoxia 74.89 10.77 544 192441 49769 31454590
Lung disorder 74.40 10.77 391 192594 31921 31472438
Respiratory rate increased 74.23 10.77 170 192815 9075 31495284
Coma 73.73 10.77 85 192900 41065 31463294
Seasonal allergy 73.01 10.77 126 192859 5462 31498897
Stress 72.71 10.77 323 192662 24618 31479741
Oxygen saturation decreased 71.93 10.77 529 192456 48586 31455773
Upper respiratory tract infection 71.89 10.77 362 192623 29060 31475299
Forced vital capacity decreased 71.63 10.77 48 192937 666 31503693
Sinus congestion 71.28 10.77 117 192868 4866 31499493
Acute kidney injury 69.50 10.77 1242 191743 278472 31225887
Blood creatinine increased 69.10 10.77 293 192692 88785 31415574
Spirometry abnormal 67.97 10.77 40 192945 435 31503924
Pyrexia 67.26 10.77 1376 191609 302464 31201895
Throat irritation 66.90 10.77 164 192821 9150 31495209
Interstitial lung disease 66.88 10.77 174 192811 61229 31443130
Heart rate increased 66.74 10.77 454 192531 40656 31463703
Septic shock 66.45 10.77 195 192790 65963 31438396
Device malfunction 66.39 10.77 163 192822 9103 31495256
Renal failure 65.69 10.77 460 192525 122870 31381489
Product container issue 65.01 10.77 43 192942 583 31503776
Disease progression 64.50 10.77 307 192678 90157 31414202
Sensitivity to weather change 63.95 10.77 61 192924 1440 31502919
Myelosuppression 63.42 10.77 8 192977 14912 31489447
Neuropathy peripheral 62.32 10.77 243 192742 75406 31428953
Pneumocystis jirovecii pneumonia 62.23 10.77 17 192968 18234 31486125
Rhabdomyolysis 61.99 10.77 190 192795 63391 31440968
Increased bronchial secretion 60.09 10.77 64 192921 1730 31502629
Bronchospasm paradoxical 59.78 10.77 20 192965 42 31504317
Conjunctivitis allergic 59.32 10.77 44 192941 724 31503635
Device ineffective 59.17 10.77 17 192968 15 31504344
Neutrophil count decreased 58.95 10.77 121 192864 46273 31458086
Circumstance or information capable of leading to device use error 58.90 10.77 15 192970 3 31504356
Sleep apnoea syndrome 57.96 10.77 246 192739 18379 31485980
Sleep terror 57.64 10.77 43 192942 714 31503645
Disseminated intravascular coagulation 56.68 10.77 27 192958 20510 31483849
Cerebral infarction 56.63 10.77 45 192940 25932 31478427
Mite allergy 56.31 10.77 34 192951 389 31503970
Inhalation therapy 55.75 10.77 16 192969 14 31504345
Right atrial hypertrophy 55.46 10.77 39 192946 588 31503771
Lung diffusion test decreased 54.88 10.77 38 192947 558 31503801
Cardiac failure 54.87 10.77 303 192682 85650 31418709
Chest X-ray abnormal 54.74 10.77 93 192892 3980 31500379
Appendicolith 54.70 10.77 113 192872 5618 31498741
Oropharyngeal pain 54.30 10.77 353 192632 31130 31473229
Respiratory distress 54.13 10.77 370 192615 33183 31471176
Restrictive pulmonary disease 54.05 10.77 49 192936 1082 31503277
Stomatitis 53.45 10.77 99 192886 39339 31465020
Lower respiratory tract congestion 53.08 10.77 47 192938 1005 31503354
Throat tightness 52.93 10.77 133 192852 7536 31496823
Rhonchi 52.78 10.77 59 192926 1686 31502673
Respiratory tract infection 51.62 10.77 228 192757 17333 31487026
Allergy to animal 50.79 10.77 28 192957 266 31504093
Drug reaction with eosinophilia and systemic symptoms 50.60 10.77 65 192920 29953 31474406
Overdose 50.53 10.77 305 192680 84359 31420000
Multiple allergies 50.41 10.77 68 192917 2367 31501992
Hepatotoxicity 50.00 10.77 27 192958 19099 31485260
Dermatitis atopic 48.93 10.77 98 192887 4764 31499595
Blood lactate dehydrogenase increased 48.55 10.77 32 192953 20307 31484052
Rhinitis 48.51 10.77 100 192885 4964 31499395
Respiratory symptom 48.06 10.77 49 192936 1257 31503102
Hypoventilation 47.83 10.77 75 192910 2999 31501360
Mycotic allergy 47.72 10.77 29 192956 336 31504023
Plasma cell myeloma 47.57 10.77 180 192805 56351 31448008
Cerebral haemorrhage 47.52 10.77 79 192906 32733 31471626
Drug-induced liver injury 47.34 10.77 47 192938 24316 31480043
Drug intolerance 46.89 10.77 161 192824 51872 31452487
Bronchiolitis 46.79 10.77 72 192913 2832 31501527
C-reactive protein increased 45.57 10.77 148 192837 48502 31455857
Synovitis 44.67 10.77 10 192975 12273 31492086
Peak expiratory flow rate decreased 44.66 10.77 20 192965 115 31504244
Obesity 44.64 10.77 159 192826 10941 31493418
Dyspnoea at rest 44.03 10.77 78 192907 3453 31500906
Pulmonary mass 42.97 10.77 159 192826 11147 31493212
Body temperature decreased 42.64 10.77 163 192822 11607 31492752
Death 42.47 10.77 1780 191205 358789 31145570
Respiratory failure 42.47 10.77 860 192125 100589 31403770
Wrong technique in device usage process 42.47 10.77 45 192940 1209 31503150
Acute myeloid leukaemia 42.42 10.77 31 192954 18641 31485718
Status asthmaticus 41.93 10.77 25 192960 279 31504080
Blood cholesterol 41.78 10.77 22 192963 189 31504170
Palmar-plantar erythrodysaesthesia syndrome 41.75 10.77 21 192964 15462 31488897
Product complaint 41.53 10.77 99 192886 5425 31498934
Anaphylactic reaction 41.38 10.77 315 192670 29238 31475121
Increased viscosity of bronchial secretion 41.20 10.77 22 192963 195 31504164
Serotonin syndrome 40.32 10.77 33 192952 18740 31485619
Rales 40.25 10.77 130 192855 8509 31495850
Forced expiratory flow decreased 39.82 10.77 20 192965 154 31504205
Spinal muscular atrophy 39.73 10.77 27 192958 384 31503975
Atelectasis 39.41 10.77 199 192786 15990 31488369
Cystic fibrosis respiratory infection suppression 39.29 10.77 22 192963 216 31504143
Agranulocytosis 39.02 10.77 43 192942 21204 31483155
Painful respiration 39.00 10.77 42 192943 1150 31503209
Sopor 38.93 10.77 11 192974 11541 31492818
Sputum abnormal 38.78 10.77 28 192957 441 31503918
Crepitations 38.22 10.77 66 192919 2862 31501497
Suicide attempt 37.96 10.77 109 192876 37139 31467220
Congenital hiatus hernia 37.45 10.77 30 192955 556 31503803
Airway remodelling 37.33 10.77 19 192966 151 31504208
Choking 37.24 10.77 85 192900 4527 31499832
Neuroleptic malignant syndrome 37.05 10.77 29 192956 16840 31487519
Progressive multifocal leukoencephalopathy 36.69 10.77 6 192979 9207 31495152
Illness 36.55 10.77 132 192853 9145 31495214
Cytopenia 36.16 10.77 11 192974 10999 31493360
Tubulointerstitial nephritis 35.57 10.77 36 192949 18460 31485899
Rhinitis allergic 35.53 10.77 63 192922 2791 31501568
Respiratory tract irritation 35.47 10.77 18 192967 142 31504217
Acute respiratory failure 35.42 10.77 292 192693 27763 31476596
Posterior reversible encephalopathy syndrome 35.35 10.77 7 192978 9360 31494999
Eye pruritus 35.35 10.77 88 192897 4957 31499402
Rhinitis perennial 35.21 10.77 23 192962 305 31504054
Circumstance or information capable of leading to medication error 35.08 10.77 46 192939 1557 31502802
Altered state of consciousness 35.05 10.77 46 192939 21005 31483354
Smoke sensitivity 34.97 10.77 17 192968 121 31504238
Cardio-respiratory arrest 34.85 10.77 179 192806 51547 31452812
Hyperthermia 34.71 10.77 9 192976 9995 31494364
Eosinophilia 34.34 10.77 251 192734 23002 31481357
Throat clearing 34.29 10.77 21 192964 247 31504112
Osteonecrosis of jaw 34.25 10.77 32 192953 17039 31487320
Food allergy 33.64 10.77 37 192948 1038 31503321
Respiration abnormal 33.48 10.77 61 192924 2761 31501598
Right ventricular hypertrophy 33.45 10.77 40 192945 1231 31503128
C-reactive protein abnormal 33.42 10.77 4 192981 7765 31496594
Sneezing 33.33 10.77 83 192902 4676 31499683
Thrombotic microangiopathy 33.24 10.77 8 192977 9343 31495016
Depressed level of consciousness 32.41 10.77 123 192862 38478 31465881
Vocal cord dysfunction 32.39 10.77 17 192968 145 31504214
Sleep disorder 32.07 10.77 272 192713 26076 31478283
Discomfort 31.71 10.77 189 192796 16167 31488192
Graft versus host disease 31.60 10.77 12 192973 10435 31493924
Forced expiratory volume 31.42 10.77 15 192970 102 31504257
Fractional exhaled nitric oxide increased 31.42 10.77 28 192957 604 31503755
Decreased activity 31.34 10.77 72 192913 3851 31500508
Poisoning 31.32 10.77 12 192973 10379 31493980
Cytokine release syndrome 31.32 10.77 33 192952 16609 31487750
Neoplasm progression 31.06 10.77 47 192938 20225 31484134
Hepatic failure 30.96 10.77 99 192886 32603 31471756
Dysphonia 30.82 10.77 223 192762 20368 31483991
Polyneuropathy 30.39 10.77 21 192964 13001 31491358
Breath alcohol test positive 30.33 10.77 8 192977 3 31504356
Superinfection 30.28 10.77 51 192934 2167 31502192
Eosinophilic bronchitis 30.10 10.77 17 192968 170 31504189
Hormone receptor positive breast cancer 29.89 10.77 10 192975 21 31504338
Pathogen resistance 29.86 10.77 8 192977 8693 31495666
FEV1/FVC ratio decreased 29.85 10.77 14 192971 91 31504268
Chest pain 29.71 10.77 927 192058 116030 31388329
Transplant rejection 29.62 10.77 11 192974 9697 31494662
Increased upper airway secretion 29.61 10.77 43 192942 1605 31502754
Psoriatic arthropathy 29.60 10.77 47 192938 19836 31484523
Victim of child abuse 29.60 10.77 32 192953 880 31503479
Eosinophil count 29.60 10.77 15 192970 118 31504241
Hypotension 29.37 10.77 986 191999 203632 31300727
Hepatitis 29.36 10.77 56 192929 22010 31482349
Blood immunoglobulin E decreased 29.20 10.77 11 192974 37 31504322
Therapy partial responder 29.19 10.77 3 192982 6559 31497800
Colitis 29.09 10.77 107 192878 33780 31470579
Encephalopathy 28.90 10.77 101 192884 32373 31471986
Pickwickian syndrome 28.82 10.77 12 192973 56 31504303
Suffocation feeling 28.73 10.77 25 192960 522 31503837
Haemoglobin decreased 28.60 10.77 498 192487 112177 31392182
Nasal inflammation 28.59 10.77 18 192967 223 31504136
Neurotoxicity 28.54 10.77 34 192951 16192 31488167
Haemophagocytic lymphohistiocytosis 28.38 10.77 18 192967 11660 31492699
Prostate cancer 28.32 10.77 125 192860 37476 31466883
Peritonitis 28.16 10.77 31 192954 15296 31489063
Pancreatitis 28.12 10.77 117 192868 35654 31468705
Nasal disorder 27.93 10.77 43 192942 1692 31502667
Upper respiratory fungal infection 27.80 10.77 15 192970 136 31504223
Metabolic acidosis 27.78 10.77 135 192850 39442 31464917
Lymph node calcification 27.71 10.77 15 192970 137 31504222
Product delivery mechanism issue 27.62 10.77 15 192970 138 31504221
Therapy non-responder 27.57 10.77 109 192876 33702 31470657
Lower respiratory tract infection bacterial 27.54 10.77 23 192962 453 31503906
Snoring 27.51 10.77 58 192927 2925 31501434
Perfume sensitivity 27.40 10.77 13 192972 87 31504272
Multiple organ dysfunction syndrome 27.38 10.77 274 192711 67929 31436430
Liver disorder 27.38 10.77 91 192894 29616 31474743
Factitious disorder 27.37 10.77 11 192974 46 31504313
Anxiety 27.36 10.77 737 192248 90296 31414063
Osteoporosis 27.23 10.77 141 192844 11442 31492917
Foetal exposure during pregnancy 27.22 10.77 142 192843 40734 31463625
Pneumonia lipoid 26.94 10.77 12 192973 68 31504291
Stoma closure 26.79 10.77 18 192967 251 31504108
Hyperbilirubinaemia 26.65 10.77 34 192951 15716 31488643
Soft tissue mass 26.61 10.77 29 192956 805 31503554
Viral infection 26.37 10.77 174 192811 15419 31488940
Product taste abnormal 26.30 10.77 33 192952 1068 31503291
Akathisia 26.19 10.77 6 192979 7247 31497112
Confusional state 26.15 10.77 615 192370 132719 31371640
Parathyroid gland enlargement 26.13 10.77 14 192971 125 31504234
Total lung capacity decreased 25.80 10.77 25 192960 602 31503757
Tracheal disorder 25.76 10.77 14 192971 129 31504230
Hypersensitivity 25.48 10.77 479 192506 55264 31449095
Hypercapnia 25.47 10.77 67 192918 3904 31500455
Eye swelling 25.36 10.77 117 192868 9059 31495300
Appendicitis 25.19 10.77 137 192848 11328 31493031
Hepatocellular injury 25.04 10.77 59 192926 21485 31482874
Wolff-Parkinson-White syndrome 25.03 10.77 16 192969 204 31504155
Disease complication 25.01 10.77 51 192934 2512 31501847
Respiratory syncytial virus infection 24.95 10.77 65 192920 3766 31500593
Herpes zoster 24.92 10.77 105 192880 31888 31472471
Chronic kidney disease 24.69 10.77 133 192852 37842 31466517
Seizure 24.66 10.77 443 192542 99325 31405034
Hypopnoea 24.29 10.77 35 192950 1297 31503062
Tumour lysis syndrome 24.22 10.77 35 192950 15350 31489009
Pneumococcal sepsis 24.18 10.77 30 192955 960 31503399
Mean platelet volume increased 24.07 10.77 22 192963 491 31503868
Ocular discomfort 24.00 10.77 42 192943 1841 31502518
Psoriasis 23.99 10.77 176 192809 46543 31457816
Blood pressure systolic increased 23.70 10.77 201 192784 19269 31485090
Ear infection 23.64 10.77 112 192873 8769 31495590
Drug eruption 23.46 10.77 47 192938 18140 31486219
Foetal malformation 23.45 10.77 13 192972 125 31504234
Mycobacterium avium complex infection 23.35 10.77 48 192937 2378 31501981
Alanine aminotransferase increased 23.35 10.77 317 192668 74339 31430020
Gamma-glutamyltransferase increased 23.14 10.77 89 192896 27736 31476623
Aspartate aminotransferase increased 23.13 10.77 257 192728 62462 31441897
Haematochezia 22.97 10.77 148 192837 40316 31464043
Myelodysplastic syndrome 22.96 10.77 52 192933 19199 31485160
Low birth weight baby 22.83 10.77 7 192978 6963 31497396
Proteinuria 22.78 10.77 42 192943 16721 31487638
Epstein-Barr virus infection 22.74 10.77 7 192978 6946 31497413
Hepatitis B 22.50 10.77 4 192981 5777 31498582
Skin discomfort 22.31 10.77 11 192974 81 31504278
Cystitis haemorrhagic 22.08 10.77 3 192982 5286 31499073
Disorientation 22.08 10.77 104 192881 30640 31473719
Metastases to liver 22.03 10.77 27 192958 12700 31491659
Shock haemorrhagic 21.72 10.77 18 192967 10159 31494200
Intentional product use issue 21.62 10.77 194 192791 49153 31455206
Nightmare 21.48 10.77 137 192848 12000 31492359
Right atrial enlargement 21.45 10.77 15 192970 224 31504135
Pancreatitis acute 21.21 10.77 82 192903 25518 31478841
Mycobacterial infection 21.14 10.77 44 192941 2199 31502160
Tachypnoea 21.04 10.77 172 192813 16311 31488048
Hyperkalaemia 20.94 10.77 271 192714 64080 31440279
Swollen tongue 20.83 10.77 142 192843 12720 31491639
Blood bilirubin increased 20.72 10.77 127 192858 35009 31469350
Sepsis 20.64 10.77 737 192248 151192 31353167
Aspirin-exacerbated respiratory disease 20.64 10.77 18 192967 377 31503982
Nasal discharge discolouration 20.52 10.77 15 192970 241 31504118
Atopy 20.52 10.77 13 192972 163 31504196
Oesophageal polyp 20.50 10.77 9 192976 49 31504310
Rhinalgia 20.48 10.77 18 192967 381 31503978
Extrapyramidal disorder 20.37 10.77 25 192960 11753 31492606
Bronchial irritation 20.23 10.77 7 192978 17 31504342
Product administered to patient of inappropriate age 20.19 10.77 50 192935 2807 31501552
Motor neurone disease 20.16 10.77 20 192965 496 31503863
Factor V Leiden mutation 20.13 10.77 10 192975 75 31504284
Diffuse large B-cell lymphoma 20.08 10.77 14 192971 8627 31495732
Cerebral artery thrombosis 20.06 10.77 24 192961 739 31503620
Blood pressure fluctuation 20.03 10.77 71 192914 22665 31481694
Forced expiratory volume abnormal 19.99 10.77 8 192977 33 31504326
Polyp 19.90 10.77 55 192930 3301 31501058
Restlessness 19.89 10.77 74 192911 23287 31481072
Cytomegalovirus viraemia 19.89 10.77 8 192977 6717 31497642
Fall 19.88 10.77 928 192057 185161 31319198
Blood alkaline phosphatase increased 19.79 10.77 102 192883 29351 31475008
Aortic valve stenosis 19.66 10.77 45 192940 2401 31501958
Pulmonary congestion 19.66 10.77 141 192844 12842 31491517
Musculoskeletal stiffness 19.65 10.77 159 192826 41166 31463193
Epidural lipomatosis 19.54 10.77 24 192961 760 31503599
Haematuria 19.45 10.77 184 192801 46130 31458229
Kidney transplant rejection 19.45 10.77 10 192975 7272 31497087
Mucormycosis 19.34 10.77 5 192980 5565 31498794
Squamous cell carcinoma 19.31 10.77 22 192963 10689 31493670
Accidental exposure to product 19.26 10.77 25 192960 11470 31492889
Nasal oedema 19.25 10.77 16 192969 313 31504046
Cholestasis 19.10 10.77 83 192902 24992 31479367
Paranasal sinus discomfort 19.05 10.77 23 192962 715 31503644
Benign prostatic hyperplasia 18.99 10.77 141 192844 12984 31491375
Encephalitis toxic 18.95 10.77 15 192970 273 31504086
Attention-seeking behaviour 18.93 10.77 8 192977 39 31504320
Multimorbidity 18.90 10.77 23 192962 721 31503638
Transaminases increased 18.89 10.77 80 192905 24261 31480098
Chronic respiratory failure 18.89 10.77 31 192954 1289 31503070
Blood creatine phosphokinase increased 18.83 10.77 164 192821 41810 31462549
Urinary tract infection 18.77 10.77 342 192643 76527 31427832
Nephropathy toxic 18.70 10.77 25 192960 11328 31493031
Toxic epidermal necrolysis 18.55 10.77 59 192926 19465 31484894
Social avoidant behaviour 18.48 10.77 50 192935 2963 31501396
Brain oedema 18.48 10.77 31 192954 12801 31491558
Product use in unapproved indication 18.45 10.77 461 192524 98710 31405649
Lung diffusion disorder 18.41 10.77 10 192975 92 31504267
Animal scratch 18.32 10.77 13 192972 199 31504160
Anosmia 18.31 10.77 40 192945 2068 31502291
Cor pulmonale acute 18.29 10.77 14 192971 242 31504117
Second primary malignancy 18.27 10.77 10 192975 7022 31497337
Dehydration 18.24 10.77 569 192416 118542 31385817
Myoclonus 18.18 10.77 36 192949 13954 31490405
Acute generalised exanthematous pustulosis 18.16 10.77 7 192978 6033 31498326
Jaundice 18.11 10.77 109 192876 30178 31474181
Infusion related reaction 18.08 10.77 196 192789 47859 31456500
Total lung capacity abnormal 17.99 10.77 11 192974 129 31504230
Mood swings 17.88 10.77 91 192894 7333 31497026
Cystic fibrosis related diabetes 17.88 10.77 12 192973 167 31504192
Myocardial infarction 17.86 10.77 540 192445 112914 31391445
Febrile bone marrow aplasia 17.85 10.77 13 192972 7833 31496526
Shock 17.84 10.77 74 192911 22571 31481788
Hypoacusis 17.81 10.77 154 192831 14845 31489514
Lung opacity 17.79 10.77 34 192951 1596 31502763
Schizophrenia 17.69 10.77 24 192961 10806 31493553
Lymphadenectomy 17.51 10.77 16 192969 357 31504002
Psychotic disorder 17.46 10.77 73 192912 22220 31482139
Acute graft versus host disease in skin 17.44 10.77 4 192981 4828 31499531
Viral upper respiratory tract infection 17.40 10.77 45 192940 2595 31501764
Urinary retention 17.33 10.77 127 192858 33598 31470761
Decreased gait velocity 17.29 10.77 11 192974 139 31504220
Brain injury 17.22 10.77 76 192909 5774 31498585
Drug ineffective 17.20 10.77 2128 190857 393445 31110914
Sputum purulent 17.13 10.77 17 192968 422 31503937
Accessory spleen 17.09 10.77 11 192974 142 31504217
Blood urine 17.06 10.77 17 192968 424 31503935
Poisoning deliberate 16.93 10.77 12 192973 7332 31497027
Hepatic steatosis 16.92 10.77 47 192938 16192 31488167
Dry skin 16.92 10.77 233 192752 25248 31479111
Pharyngeal oedema 16.84 10.77 75 192910 5721 31498638
Scoliosis 16.82 10.77 44 192941 2555 31501804
Cystic fibrosis lung 16.81 10.77 8 192977 54 31504305
Social problem 16.80 10.77 23 192962 812 31503547
Anuria 16.80 10.77 21 192964 9793 31494566
Plantar fasciitis 16.79 10.77 33 192952 1582 31502777
Enterococcal infection 16.78 10.77 17 192968 8714 31495645
Panic reaction 16.71 10.77 30 192955 1342 31503017
Renal tubular necrosis 16.69 10.77 41 192944 14718 31489641
Infective exacerbation of chronic obstructive airways disease 16.68 10.77 34 192951 1674 31502685
Haemorrhage 16.65 10.77 196 192789 47138 31457221
Metastases to lung 16.65 10.77 16 192969 8406 31495953
Hypercalcaemia 16.55 10.77 38 192947 13962 31490397
Lip swelling 16.45 10.77 138 192847 13185 31491174
Bed bug infestation 16.43 10.77 4 192981 0 31504359
Sensory integrative dysfunction 16.42 10.77 7 192978 35 31504324
Device related infection 16.38 10.77 48 192937 16251 31488108
Brain scan abnormal 16.32 10.77 23 192962 835 31503524
Aptyalism 16.30 10.77 14 192971 287 31504072
Lymphocyte count abnormal 16.28 10.77 22 192963 767 31503592
Pancreatic carcinoma 16.24 10.77 17 192968 8583 31495776
Anger 16.24 10.77 120 192865 11033 31493326
Withdrawal syndrome 16.24 10.77 29 192956 11688 31492671
Gait disturbance 16.15 10.77 354 192631 77141 31427218
Bradycardia 16.13 10.77 311 192674 69016 31435343
Resuscitation 16.11 10.77 30 192955 1381 31502978
Hepatitis cholestatic 16.05 10.77 12 192973 7134 31497225
Drug ineffective for unapproved indication 16.05 10.77 55 192930 17735 31486624
Carbon dioxide increased 16.05 10.77 25 192960 994 31503365
Swelling face 16.05 10.77 200 192785 21190 31483169
Oliguria 16.04 10.77 14 192971 7703 31496656
Inspiratory capacity abnormal 15.93 10.77 9 192976 90 31504269
Sinus operation 15.91 10.77 19 192966 584 31503775
Ventricular hyperkinesia 15.90 10.77 12 192973 203 31504156
Product cleaning inadequate 15.81 10.77 5 192980 8 31504351
Pleural thickening 15.79 10.77 14 192971 300 31504059
Sinus disorder 15.76 10.77 78 192907 6217 31498142
Sinus polyp 15.75 10.77 11 192974 164 31504195
Blood pressure increased 15.66 10.77 613 192372 79020 31425339
Rhinovirus infection 15.66 10.77 52 192933 3453 31500906
Suspected suicide 15.65 10.77 3 192982 4104 31500255
Subdural haematoma 15.57 10.77 61 192924 18910 31485449
Sarcopenia 15.56 10.77 15 192970 359 31504000
Cockroach allergy 15.53 10.77 7 192978 41 31504318
Diastolic dysfunction 15.47 10.77 69 192916 5266 31499093
Asthma exercise induced 15.44 10.77 9 192976 96 31504263
Blood phosphorus increased 15.36 10.77 61 192924 4421 31499938
Sensation of foreign body 15.35 10.77 38 192947 2133 31502226
End stage renal disease 15.35 10.77 16 192969 8093 31496266
Renal disorder 15.26 10.77 83 192902 23562 31480797
Joint swelling 15.25 10.77 231 192754 53200 31451159
Asthenia 15.23 10.77 1170 191815 223585 31280774
Klebsiella infection 15.22 10.77 15 192970 7788 31496571
Basal cell carcinoma 15.21 10.77 58 192927 18121 31486238
Bradyphrenia 15.20 10.77 4 192981 4400 31499959
Squamous cell carcinoma of skin 15.19 10.77 24 192961 10150 31494209
Oesophageal perforation 15.19 10.77 24 192961 966 31503393
BK virus infection 15.17 10.77 6 192979 5089 31499270
Rash maculo-papular 15.14 10.77 93 192892 25626 31478733
Flour sensitivity 15.13 10.77 6 192979 24 31504335
Ataxia 15.13 10.77 35 192950 12828 31491531
Endotracheal intubation 15.04 10.77 45 192940 2825 31501534
Intentional device misuse 15.04 10.77 11 192974 177 31504182
Blood urea increased 15.03 10.77 109 192876 28903 31475456
Mycobacterium test positive 15.02 10.77 15 192970 375 31503984
Miosis 15.02 10.77 18 192967 8552 31495807
Ileus 15.01 10.77 45 192940 15124 31489235
Somnolence 14.99 10.77 476 192509 98969 31405390
Substance abuse 14.86 10.77 13 192972 7145 31497214
Post-tussive vomiting 14.79 10.77 5 192980 11 31504348
Acute myocardial infarction 14.75 10.77 219 192766 50604 31453755
Hepatocellular carcinoma 14.71 10.77 19 192966 8737 31495622
Wrong technique in product usage process 14.71 10.77 285 192700 33058 31471301
Mouth swelling 14.65 10.77 32 192953 1654 31502705
Haemophilus infection 14.62 10.77 24 192961 998 31503361
Diastolic hypotension 14.62 10.77 7 192978 48 31504311
Encephalitis 14.61 10.77 12 192973 6803 31497556
Lymphopenia 14.54 10.77 42 192943 14287 31490072
Migraine 14.51 10.77 141 192844 14039 31490320
Product prescribing error 14.45 10.77 183 192802 19459 31484900
Rubber sensitivity 14.43 10.77 10 192975 147 31504212
Lymphoma 14.36 10.77 28 192957 10915 31493444
Bladder cancer 14.34 10.77 44 192941 14681 31489678
Renal injury 14.24 10.77 27 192958 10638 31493721
Small airways disease 14.24 10.77 6 192979 29 31504330
Frustration tolerance decreased 14.23 10.77 39 192946 2329 31502030
Foreign body aspiration 14.15 10.77 10 192975 152 31504207
Chronic respiratory disease 14.15 10.77 7 192978 52 31504307
Respiratory tract infection bacterial 14.10 10.77 29 192956 1437 31502922
Hypertriglyceridaemia 14.08 10.77 16 192969 7782 31496577
Influenza B virus test positive 14.00 10.77 8 192977 82 31504277
Toxic encephalopathy 13.97 10.77 6 192979 4844 31499515
Alveolar bone resorption 13.95 10.77 5 192980 14 31504345
Hepatic cytolysis 13.93 10.77 28 192957 10795 31493564
Bronchopulmonary aspergillosis 13.81 10.77 40 192945 13594 31490765
Pain 13.81 10.77 965 192020 185794 31318565
Multiple-drug resistance 13.79 10.77 5 192980 4475 31499884
Gastroenteritis viral 13.79 10.77 75 192910 6202 31498157
Infective exacerbation of bronchiectasis 13.75 10.77 15 192970 417 31503942
Drug level decreased 13.72 10.77 13 192972 6877 31497482
Immune thrombocytopenia 13.71 10.77 19 192966 8479 31495880
Colitis ulcerative 13.71 10.77 62 192923 18467 31485892
Tracheostomy malfunction 13.61 10.77 7 192978 57 31504302
Urticaria 13.57 10.77 452 192533 57065 31447294
Lacrimal disorder 13.52 10.77 13 192972 310 31504049
Aplastic anaemia 13.47 10.77 22 192963 9181 31495178
Pulmonary toxicity 13.47 10.77 8 192977 5369 31498990
Stridor 13.46 10.77 38 192947 2309 31502050
Aphasia 13.40 10.77 69 192916 19862 31484497
Deep vein thrombosis 13.37 10.77 275 192710 60461 31443898
Red cell distribution width increased 13.37 10.77 67 192918 5367 31498992
Product distribution issue 13.33 10.77 15 192970 432 31503927
Exercise tolerance decreased 13.33 10.77 60 192925 4598 31499761
Cardiac arrest 13.25 10.77 427 192558 88635 31415724
Multiple sclerosis relapse 13.21 10.77 34 192951 12013 31492346
Escherichia infection 13.17 10.77 15 192970 7289 31497070
Lung hernia 13.11 10.77 7 192978 62 31504297
Use of accessory respiratory muscles 13.10 10.77 14 192971 380 31503979
General physical health deterioration 13.05 10.77 561 192424 112874 31391485
Drug use disorder 13.04 10.77 4 192981 3979 31500380
Endophthalmitis 13.04 10.77 3 192982 3613 31500746
Hypoalbuminaemia 12.98 10.77 30 192955 10998 31493361
Alanine aminotransferase abnormal 12.96 10.77 4 192981 3963 31500396
Joint injury 12.96 10.77 87 192898 7754 31496605
Drug level increased 12.95 10.77 71 192914 20115 31484244
Graft versus host disease in skin 12.94 10.77 3 192982 3594 31500765
Haemolytic anaemia 12.91 10.77 25 192960 9771 31494588
Vascular shunt 12.81 10.77 5 192980 19 31504340
Humidity intolerance 12.81 10.77 5 192980 19 31504340
Blood immunoglobulin E abnormal 12.81 10.77 5 192980 19 31504340
Blebitis 12.80 10.77 4 192981 6 31504353
Exposure to fungus 12.80 10.77 4 192981 6 31504353
Hemiparesis 12.80 10.77 47 192938 14847 31489512
Emotional disorder of childhood 12.79 10.77 6 192979 39 31504320
Palpitations 12.78 10.77 288 192697 34295 31470064
Tendon calcification 12.74 10.77 7 192978 66 31504293
Diaphragmatic disorder 12.70 10.77 24 192961 1117 31503242
Anal abscess 12.70 10.77 10 192975 5790 31498569
Eye disorder 12.68 10.77 92 192893 8410 31495949
Nervous system disorder 12.66 10.77 40 192945 13223 31491136
Hyperuricaemia 12.64 10.77 16 192969 7422 31496937
Dyskinesia 12.63 10.77 75 192910 20835 31483524
Adjustment disorder 12.60 10.77 24 192961 1124 31503235
Cortisol decreased 12.59 10.77 22 192963 963 31503396
Apnoeic attack 12.58 10.77 13 192972 339 31504020
Expiratory reserve volume decreased 12.54 10.77 6 192979 41 31504318
Upper respiratory tract congestion 12.50 10.77 19 192966 739 31503620
Ejection fraction decreased 12.50 10.77 59 192926 17375 31486984
Syringe issue 12.48 10.77 7 192978 4849 31499510
Aplasia pure red cell 12.42 10.77 10 192975 5727 31498632
Malpositioned teeth 12.42 10.77 5 192980 21 31504338
Personal relationship issue 12.38 10.77 12 192973 289 31504070
Melaena 12.36 10.77 133 192852 32521 31471838
Electrocardiogram QT shortened 12.35 10.77 9 192976 144 31504215
Neurodevelopmental disorder 12.33 10.77 14 192971 407 31503952
Physical product label issue 12.32 10.77 3 192982 0 31504359
Occupational asthma 12.32 10.77 3 192982 0 31504359
Emergency care examination 12.32 10.77 3 192982 0 31504359
Flail chest 12.32 10.77 3 192982 0 31504359
Ventricular pre-excitation 12.32 10.77 3 192982 0 31504359
Graft versus host disease in gastrointestinal tract 12.32 10.77 3 192982 3476 31500883
Colon cancer 12.22 10.77 21 192964 8592 31495767
Skin toxicity 12.21 10.77 5 192980 4154 31500205
Tracheomalacia 12.19 10.77 9 192976 147 31504212
Anal fistula 12.14 10.77 7 192978 4776 31499583
Nervous system neoplasm 12.14 10.77 9 192976 148 31504211
Hepatic enzyme increased 12.13 10.77 150 192835 35758 31468601
Hypochromasia 12.12 10.77 12 192973 297 31504062
Central nervous system lesion 12.11 10.77 11 192974 5937 31498422
Hyperglycaemia 12.08 10.77 153 192832 36323 31468036
Ischaemic cerebral infarction 12.03 10.77 24 192961 1163 31503196
B-cell lymphoma 12.03 10.77 6 192979 4439 31499920
Nasal discomfort 12.01 10.77 28 192957 1512 31502847
Prescribed underdose 11.92 10.77 20 192965 8258 31496101
Trisomy 18 11.90 10.77 13 192972 362 31503997
Pulmonary tuberculosis 11.81 10.77 7 192978 4704 31499655
Sputum retention 11.78 10.77 14 192971 428 31503931
Croup infectious 11.76 10.77 12 192973 308 31504051
Panic attack 11.75 10.77 92 192893 8611 31495748
Abnormal behaviour 11.67 10.77 207 192778 23621 31480738
Device information output issue 11.64 10.77 8 192977 116 31504243
Chest injury 11.62 10.77 27 192958 1455 31502904
Paraneoplastic rash 11.60 10.77 7 192978 80 31504279
Incorrect dose administered by device 11.56 10.77 29 192956 1641 31502718
Visual acuity reduced 11.55 10.77 51 192934 15292 31489067
Hernia pain 11.45 10.77 11 192974 262 31504097
Abnormal clotting factor 11.45 10.77 6 192979 51 31504308
Acute hepatic failure 11.43 10.77 40 192945 12819 31491540
Pulmonary eosinophilia 11.40 10.77 10 192975 211 31504148
Tracheitis 11.40 10.77 17 192968 650 31503709
Oxygen therapy 11.39 10.77 19 192966 801 31503558
Coronary artery stenosis 11.37 10.77 23 192962 8847 31495512
Cerebrovascular accident 11.37 10.77 383 192602 79101 31425258
Gastric cancer 11.36 10.77 12 192973 6033 31498326
Cholecystitis 11.32 10.77 27 192958 9790 31494569
Respiratory syncytial virus bronchiolitis 11.24 10.77 13 192972 386 31503973
Pigment dispersion syndrome 11.21 10.77 4 192981 11 31504348
Transposition of the great vessels 11.21 10.77 14 192971 451 31503908
Erythema multiforme 11.16 10.77 20 192965 8051 31496308
Bone deformity 11.16 10.77 6 192979 54 31504305
Mucosal hypertrophy 11.13 10.77 5 192980 29 31504330
Prolonged expiration 11.09 10.77 9 192976 170 31504189
Nasal septum deviation 11.08 10.77 21 192964 980 31503379
Carcinoid tumour of the gastrointestinal tract 11.07 10.77 6 192979 55 31504304
Exposure via skin contact 11.07 10.77 6 192979 55 31504304
Crying 11.06 10.77 65 192920 5532 31498827
Hepatic cancer 11.00 10.77 19 192966 7756 31496603
Electrocardiogram PR shortened 10.96 10.77 4 192981 12 31504347
Adrenal cortex necrosis 10.96 10.77 4 192981 12 31504347
Adrenocortical insufficiency acute 10.96 10.77 25 192960 1331 31503028
Sedation 10.95 10.77 69 192916 18896 31485463
Nausea 10.93 10.77 1677 191308 306270 31198089
Hypertensive crisis 10.91 10.77 21 192964 8226 31496133
Oropharyngeal oedema 10.88 10.77 6 192979 57 31504302
Congestive cardiomyopathy 10.88 10.77 16 192969 6966 31497393
Dermatitis exfoliative generalised 10.87 10.77 3 192982 3196 31501163
Limb injury 10.85 10.77 101 192884 9940 31494419
Hepatic fibrosis 10.83 10.77 5 192980 3869 31500490
Intentional self-injury 10.81 10.77 43 192942 13272 31491087
Haemolysis 10.80 10.77 17 192968 7199 31497160

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 10177.52 10.05 7463 453486 113330 70354165
Wheezing 4179.12 10.05 4024 456925 90146 70377349
Dyspnoea 3125.93 10.05 11508 449441 758552 69708943
Obstructive airways disorder 2195.63 10.05 1615 459334 24498 70442997
Cough 1919.34 10.05 5536 455413 319841 70147654
Chronic obstructive pulmonary disease 1907.87 10.05 2436 458513 75205 70392290
Full blood count abnormal 1625.24 10.05 1513 459436 32365 70435130
Poor quality device used 1508.58 10.05 553 460396 1545 70465950
Productive cough 1507.20 10.05 2183 458766 76154 70391341
Forced expiratory volume decreased 1298.49 10.05 725 460224 6589 70460906
Product quality issue 1241.90 10.05 1246 459703 29315 70438180
Sleep disorder due to a general medical condition 1207.85 10.05 787 460162 9689 70457806
Infective pulmonary exacerbation of cystic fibrosis 1120.02 10.05 795 460154 11363 70456132
Completed suicide 1069.61 10.05 115 460834 227020 70240475
Sputum discoloured 1033.96 10.05 908 460041 17943 70449552
Chest discomfort 1012.01 10.05 2390 458559 121991 70345504
Pneumonia 651.78 10.05 6317 454632 589915 69877580
Synovitis 596.54 10.05 70 460879 129158 70338337
Off label use 567.15 10.05 2695 458254 740365 69727130
Toxicity to various agents 560.95 10.05 1017 459932 381155 70086340
Bronchitis 554.32 10.05 1850 459099 115393 70352102
Rheumatoid arthritis 553.17 10.05 649 460300 291156 70176339
Pemphigus 478.50 10.05 13 460936 83023 70384472
Therapeutic product effect incomplete 475.87 10.05 1786 459163 118096 70349399
Drug abuse 466.96 10.05 186 460763 147070 70320425
Nasal congestion 464.88 10.05 1197 459752 64475 70403020
Hand deformity 453.38 10.05 27 460922 86455 70381040
Middle insomnia 448.41 10.05 504 460445 13549 70453946
Treatment failure 439.46 10.05 193 460756 143949 70323546
Drug intolerance 430.71 10.05 499 460450 225188 70242307
Dyspnoea exertional 430.38 10.05 1303 459646 77127 70390368
Neutropenia 404.75 10.05 654 460295 256502 70210993
Pulmonary function test decreased 404.12 10.05 343 460606 6458 70461037
Bronchiectasis 402.71 10.05 510 460439 15587 70451908
Respiratory disorder 401.86 10.05 826 460123 38297 70429198
Anti-cyclic citrullinated peptide antibody positive 386.73 10.05 16 460933 70169 70397326
Nasal polyps 383.23 10.05 281 460668 4235 70463260
Lower respiratory tract infection 377.04 10.05 1584 459365 110329 70357166
Loss of personal independence in daily activities 365.55 10.05 1299 459650 83611 70383884
Febrile neutropenia 362.24 10.05 478 460471 203840 70263655
Cystic fibrosis 353.43 10.05 262 460687 4019 70463476
Systemic lupus erythematosus 351.53 10.05 112 460837 101790 70365705
Blood immunoglobulin E increased 348.94 10.05 271 460678 4473 70463022
Arthropathy 335.22 10.05 289 460660 149768 70317727
Bronchospasm 326.42 10.05 555 460394 22237 70445258
Drug interaction 319.12 10.05 1335 459614 380106 70087389
Thrombocytopenia 318.61 10.05 673 460276 238437 70229058
Product dose omission issue 312.93 10.05 2451 458498 215017 70252478
Breath sounds abnormal 311.83 10.05 407 460542 12824 70454671
Pericarditis 301.37 10.05 88 460861 84617 70382878
Drug ineffective 299.30 10.05 4308 456641 935444 69532051
Glossodynia 294.88 10.05 97 460852 86390 70381105
Eosinophil count increased 292.12 10.05 424 460525 14798 70452697
Influenza 273.76 10.05 1460 459489 112240 70355255
Therapeutic product effect decreased 268.64 10.05 320 460629 142698 70324797
Sleep apnoea syndrome 265.00 10.05 628 460321 32085 70435410
Pancytopenia 260.17 10.05 361 460588 150746 70316749
Infusion related reaction 254.78 10.05 566 460383 196968 70270527
Alopecia 254.16 10.05 571 460378 197919 70269576
Gastrooesophageal reflux disease 249.86 10.05 1211 459738 89628 70377867
Intentional overdose 248.67 10.05 167 460782 98268 70369227
Device delivery system issue 243.05 10.05 102 460847 450 70467045
Helicobacter infection 240.46 10.05 37 460912 55619 70411876
Anaemia 239.25 10.05 1587 459362 401836 70065659
Upper respiratory tract infection 237.91 10.05 1084 459865 78190 70389305
Contraindicated product administered 229.33 10.05 324 460625 134288 70333207
Duodenal ulcer perforation 223.06 10.05 33 460916 51079 70416416
Secretion discharge 222.09 10.05 342 460607 12591 70454904
Hepatic function abnormal 220.24 10.05 83 460866 67913 70399582
Blood test abnormal 219.21 10.05 363 460586 14227 70453268
Bronchopulmonary aspergillosis allergic 214.97 10.05 143 460806 1826 70465669
Heart rate increased 210.84 10.05 1295 459654 104853 70362642
Hepatic enzyme increased 209.72 10.05 441 460508 156549 70310946
Upper-airway cough syndrome 208.89 10.05 286 460663 9445 70458050
Malignant neoplasm progression 207.38 10.05 293 460656 121446 70346049
Oropharyngeal pain 204.72 10.05 1196 459753 95114 70372381
Sinusitis 203.38 10.05 1832 459117 167363 70300132
Platelet count decreased 202.78 10.05 545 460404 177677 70289818
Reversible airways obstruction 195.75 10.05 125 460824 1482 70466013
Respiratory tract congestion 188.71 10.05 379 460570 17274 70450221
Eosinophilic granulomatosis with polyangiitis 186.72 10.05 160 460789 3053 70464442
Sensitivity to weather change 184.24 10.05 234 460715 7171 70460324
Seasonal allergy 183.45 10.05 321 460628 13163 70454332
Forced vital capacity decreased 183.30 10.05 120 460829 1489 70466006
Food allergy 179.17 10.05 248 460701 8276 70459219
Bronchial wall thickening 179.08 10.05 133 460816 2046 70465449
Oxygen saturation decreased 178.31 10.05 1332 459617 115097 70352398
Asthmatic crisis 177.67 10.05 125 460824 1759 70465736
Haemoptysis 177.65 10.05 734 460215 50718 70416777
Rales 177.37 10.05 363 460586 16772 70450723
Emphysema 176.37 10.05 336 460613 14724 70452771
Leukopenia 175.08 10.05 263 460686 106297 70361198
Malaise 173.77 10.05 3855 457094 429077 70038418
Stomatitis 172.46 10.05 360 460589 128151 70339344
Pulmonary function test abnormal 171.98 10.05 157 460792 3268 70464227
Rhinitis allergic 171.25 10.05 254 460695 9041 70458454
Bronchial secretion retention 171.08 10.05 148 460801 2862 70464633
Wound 170.78 10.05 235 460714 98497 70368998
Musculoskeletal stiffness 169.46 10.05 450 460499 147310 70320185
White blood cell count decreased 168.49 10.05 555 460394 169586 70297909
Respiratory rate increased 168.46 10.05 386 460563 19286 70448209
Sedation complication 168.05 10.05 308 460641 13102 70454393
Dust allergy 166.74 10.05 101 460848 1083 70466412
Ear pain 162.22 10.05 470 460479 27129 70440366
Sputum increased 161.64 10.05 164 460785 3908 70463587
Respiratory tract infection 160.11 10.05 622 460327 41776 70425719
Cytomegalovirus infection 159.60 10.05 32 460917 39726 70427769
Lung hyperinflation 159.55 10.05 113 460836 1608 70465887
Rhinorrhoea 158.81 10.05 851 460098 65520 70401975
Muscle injury 156.59 10.05 30 460919 38464 70429031
Coma 155.46 10.05 222 460727 91622 70375873
Peak expiratory flow rate decreased 155.11 10.05 79 460870 584 70466911
Asthma-chronic obstructive pulmonary disease overlap syndrome 155.05 10.05 107 460842 1457 70466038
Anxiety 154.75 10.05 2146 458803 218184 70249311
Dysphonia 149.48 10.05 684 460265 49416 70418079
Bone marrow failure 148.69 10.05 66 460883 48944 70418551
Impaired healing 147.68 10.05 159 460790 74215 70393280
Chest pain 146.40 10.05 2370 458579 248890 70218605
Bronchial obstruction 145.02 10.05 125 460824 2405 70465090
Renal impairment 141.48 10.05 471 460478 143466 70324029
Hypoventilation 139.10 10.05 192 460757 6390 70461105
Respiration abnormal 137.28 10.05 195 460754 6669 70460826
Bronchospasm paradoxical 136.44 10.05 47 460902 102 70467393
Bronchial disorder 136.34 10.05 117 460832 2237 70465258
Myelosuppression 134.97 10.05 18 460931 30127 70437368
Joint swelling 133.87 10.05 1029 459920 252182 70215313
Urticaria 133.26 10.05 1633 459316 161416 70306079
Creatinine renal clearance decreased 132.64 10.05 324 460625 16876 70450619
C-reactive protein increased 130.20 10.05 332 460617 110185 70357310
Eosinophil count abnormal 129.68 10.05 69 460880 564 70466931
Overdose 129.64 10.05 614 460335 169131 70298364
Mucosal inflammation 128.22 10.05 151 460798 67699 70399796
Folliculitis 128.09 10.05 58 460891 42512 70424983
Sleep disorder due to general medical condition, insomnia type 127.30 10.05 37 460912 35695 70431800
Sopor 125.85 10.05 25 460924 31242 70436253
Respiratory distress 124.86 10.05 692 460257 53958 70413537
Vital capacity decreased 124.84 10.05 90 460859 1319 70466176
Polycystic ovaries 123.85 10.05 121 460828 2751 70464744
Hepatotoxicity 121.70 10.05 67 460882 43919 70423576
Respiratory symptom 121.29 10.05 136 460813 3645 70463850
Illness 119.71 10.05 466 460483 31325 70436170
Acute kidney injury 118.91 10.05 2271 458678 472353 69995142
Nasal obstruction 114.79 10.05 90 460859 1507 70465988
Product delivery mechanism issue 114.64 10.05 42 460907 117 70467378
Rheumatoid factor positive 114.51 10.05 88 460861 48312 70419183
Restrictive pulmonary disease 114.41 10.05 105 460844 2201 70465294
Hospitalisation 114.38 10.05 923 460026 81645 70385850
Suicide attempt 113.29 10.05 215 460734 79295 70388200
Abdominal discomfort 112.65 10.05 874 460075 213784 70253711
Impaired quality of life 111.99 10.05 205 460744 8711 70458784
Headache 111.47 10.05 4721 456228 575684 69891811
Drug-induced liver injury 111.35 10.05 120 460829 55993 70411502
Cardio-respiratory arrest 110.62 10.05 313 460636 100364 70367131
Drug resistance 110.35 10.05 55 460894 38135 70429360
Status asthmaticus 108.70 10.05 73 460876 948 70466547
Hypoxia 108.65 10.05 1004 459945 92340 70375155
Allergy to animal 108.58 10.05 77 460872 1098 70466397
Temperature regulation disorder 108.31 10.05 139 460810 4305 70463190
Swollen tongue 107.71 10.05 502 460447 36544 70430951
Drug reaction with eosinophilia and systemic symptoms 105.50 10.05 133 460816 57880 70409615
Cerebral infarction 104.58 10.05 76 460873 42933 70424562
Hepatocellular injury 103.79 10.05 88 460861 46003 70421492
Throat clearing 103.10 10.05 87 460862 1624 70465871
Septic shock 102.48 10.05 379 460570 111879 70355616
Disease progression 102.13 10.05 598 460351 156074 70311421
Rhinitis 101.56 10.05 229 460720 11318 70456177
Intentional product use issue 101.13 10.05 419 460530 119723 70347772
Acute respiratory failure 101.06 10.05 646 460303 53019 70414476
Maternal exposure during pregnancy 101.04 10.05 396 460553 114949 70352546
Chronic sinusitis 99.52 10.05 189 460760 8262 70459233
Interstitial lung disease 98.49 10.05 349 460600 104336 70363159
Rhonchi 98.14 10.05 120 460829 3535 70463960
Lip swelling 97.94 10.05 460 460489 33594 70433901
Mite allergy 97.43 10.05 64 460885 799 70466696
General physical health deterioration 95.99 10.05 1025 459924 235006 70232489
Pulmonary mass 95.92 10.05 379 460570 25654 70441841
Device malfunction 95.32 10.05 307 460642 18777 70448718
Neuropathy peripheral 95.12 10.05 462 460487 126434 70341061
Nasopharyngitis 95.12 10.05 1998 458951 220208 70247287
Throat tightness 94.39 10.05 367 460582 24655 70442840
Sinus disorder 93.80 10.05 304 460645 18655 70448840
Serotonin syndrome 92.90 10.05 82 460867 42032 70425463
Psoriatic arthropathy 92.40 10.05 175 460774 64596 70402899
Neutrophil count decreased 92.36 10.05 259 460690 83297 70384198
Anaphylactic reaction 92.13 10.05 816 460133 74158 70393337
Posterior reversible encephalopathy syndrome 91.20 10.05 23 460926 24379 70443116
Rheumatic fever 91.07 10.05 6 460943 17654 70449841
Sinus pain 91.02 10.05 106 460843 2963 70464532
Bronchial hyperreactivity 90.37 10.05 98 460851 2528 70464967
Lung consolidation 89.58 10.05 179 460770 8127 70459368
Altered state of consciousness 89.40 10.05 77 460872 39945 70427550
Conjunctivitis allergic 88.69 10.05 68 460881 1100 70466395
Renal failure 88.67 10.05 793 460156 188277 70279218
Lower respiratory tract congestion 88.51 10.05 109 460840 3235 70464260
Irritable bowel syndrome 86.94 10.05 122 460827 50728 70416767
Spirometry abnormal 86.85 10.05 55 460894 642 70466853
Diastolic hypotension 86.46 10.05 35 460914 138 70467357
Sensitisation 86.34 10.05 93 460856 2380 70465115
Alanine aminotransferase increased 86.27 10.05 582 460367 146898 70320597
Pneumocystis jirovecii pneumonia 85.90 10.05 44 460905 30038 70437457
Agranulocytosis 85.87 10.05 81 460868 40217 70427278
Obstruction 85.79 10.05 112 460837 3529 70463966
Increased bronchial secretion 85.41 10.05 103 460846 2990 70464505
Disseminated intravascular coagulation 84.82 10.05 57 460892 33541 70433954
Viral infection 83.64 10.05 480 460469 37911 70429584
Pyrexia 83.54 10.05 3164 457785 603788 69863707
Arthralgia 83.48 10.05 2563 458386 500827 69966668
Smoke sensitivity 82.61 10.05 49 460900 504 70466991
Orthostatic hypotension 82.60 10.05 598 460351 51145 70416350
Humidity intolerance 82.07 10.05 42 460907 314 70467181
Blood calcium decreased 81.75 10.05 388 460561 28458 70439037
Eosinophilic bronchitis 81.65 10.05 44 460905 370 70467125
Multiple allergies 81.03 10.05 165 460784 7595 70459900
Body temperature increased 80.95 10.05 489 460460 39345 70428150
Liver injury 80.04 10.05 89 460860 40946 70426549
Blood creatinine increased 79.38 10.05 573 460376 142428 70325067
Cerebral haemorrhage 79.08 10.05 143 460806 53721 70413774
Swelling 78.57 10.05 814 460135 187725 70279770
Lung diffusion test decreased 78.53 10.05 65 460884 1180 70466315
Diarrhoea 78.07 10.05 4230 456719 779111 69688384
Neurotoxicity 77.47 10.05 49 460900 29777 70437718
Eye pruritus 77.16 10.05 240 460709 14407 70453088
Aspartate aminotransferase increased 76.83 10.05 496 460453 126482 70341013
Total lung capacity increased 76.14 10.05 57 460892 888 70466607
C-reactive protein abnormal 75.99 10.05 83 460866 38496 70428999
Multiple organ dysfunction syndrome 75.14 10.05 406 460543 108109 70359386
Cardiac failure 75.00 10.05 585 460364 142956 70324539
Toxic epidermal necrolysis 74.77 10.05 88 460861 39469 70428026
Choking 74.53 10.05 198 460751 10862 70456633
Blood lactate dehydrogenase increased 74.39 10.05 71 460878 35056 70432439
Total lung capacity decreased 73.99 10.05 77 460872 1892 70465603
Neoplasm progression 73.90 10.05 112 460837 45116 70422379
Sputum purulent 73.74 10.05 63 460886 1197 70466298
Stress 73.59 10.05 720 460229 67246 70400249
Perfume sensitivity 73.56 10.05 51 460898 700 70466795
Rhabdomyolysis 73.30 10.05 346 460603 95414 70372081
Therapy non-responder 73.29 10.05 255 460694 76660 70390835
Palmar-plantar erythrodysaesthesia syndrome 72.82 10.05 54 460895 30193 70437302
Death 72.79 10.05 2647 458302 507414 69960081
Coeliac disease 72.70 10.05 173 460776 8860 70458635
Swollen joint count increased 72.63 10.05 4 460945 13696 70453799
Blood pressure systolic increased 72.32 10.05 627 460322 56632 70410863
Plasma cell myeloma 72.26 10.05 239 460710 72962 70394533
Acute myeloid leukaemia 70.99 10.05 58 460891 30882 70436613
Poisoning 70.96 10.05 29 460920 22593 70444902
Blister 70.22 10.05 375 460574 100151 70367344
Sneezing 70.05 10.05 256 460693 16695 70450800
Tubulointerstitial nephritis 69.87 10.05 67 460882 33009 70434486
Sleep terror 69.58 10.05 60 460889 1155 70466340
Metastases to liver 69.32 10.05 41 460908 25837 70441658
Thrombotic microangiopathy 68.31 10.05 16 460933 17832 70449663
Circumstance or information capable of leading to medication error 67.43 10.05 99 460850 3491 70464004
Throat irritation 67.10 10.05 426 460523 34878 70432617
Bronchiolitis 67.09 10.05 102 460847 3712 70463783
Chest X-ray abnormal 66.57 10.05 145 460804 6999 70460496
Sinus congestion 66.50 10.05 256 460693 17117 70450378
Transplant rejection 66.24 10.05 18 460931 18153 70449342
Swelling face 65.42 10.05 663 460286 62501 70404994
Palpitations 65.26 10.05 1047 459902 109706 70357789
Forced expiratory flow decreased 65.24 10.05 33 460916 240 70467255
Pharyngeal swelling 64.78 10.05 135 460814 6318 70461177
Balance disorder 64.45 10.05 881 460068 89247 70378248
Hepatic failure 64.14 10.05 178 460771 57447 70410048
Inhalation therapy 63.80 10.05 21 460928 37 70467458
Burning sensation 63.70 10.05 573 460376 52297 70415198
Nasal discharge discolouration 63.61 10.05 73 460876 2008 70465487
Cystic fibrosis respiratory infection suppression 63.57 10.05 38 460911 397 70467098
Nasal turbinate hypertrophy 63.41 10.05 43 460906 568 70466927
Lung disorder 63.40 10.05 711 460238 68773 70398722
Progressive multifocal leukoencephalopathy 62.97 10.05 23 460926 19191 70448304
Dermatitis atopic 62.48 10.05 163 460786 8844 70458651
Nasal mucosal disorder 62.12 10.05 35 460914 324 70467171
Poisoning deliberate 62.00 10.05 17 460932 17043 70450452
Decreased appetite 61.22 10.05 1510 459439 303270 70164225
Discomfort 61.19 10.05 417 460532 105019 70362476
Myelodysplastic syndrome 61.00 10.05 62 460887 29723 70437772
Cholestasis 60.96 10.05 138 460811 47734 70419761
Drug eruption 60.57 10.05 102 460847 39394 70428101
Anuria 60.35 10.05 26 460923 19627 70447868
Ejection fraction 59.32 10.05 65 460884 1697 70465798
No adverse event 59.27 10.05 385 460564 31768 70435727
Osteonecrosis of jaw 59.17 10.05 110 460839 40892 70426603
Vocal cord dysfunction 58.93 10.05 37 460912 425 70467070
Confusional state 58.76 10.05 1403 459546 282995 70184500
Fluid retention 58.02 10.05 649 460300 62736 70404759
Eczema 57.76 10.05 397 460552 33384 70434111
Lymph node calcification 57.46 10.05 34 460915 348 70467147
Venoocclusive liver disease 56.98 10.05 3 460946 10675 70456820
Product container issue 56.74 10.05 50 460899 992 70466503
Muscle spasticity 55.91 10.05 265 460684 19424 70448071
Red blood cell sedimentation rate increased 55.47 10.05 104 460845 38538 70428957
Cytokine release syndrome 55.46 10.05 54 460895 26413 70441082
Eosinophilia 55.43 10.05 450 460499 39869 70427626
Immune reconstitution inflammatory syndrome 55.28 10.05 9 460940 12981 70454514
Encephalopathy 55.07 10.05 210 460739 61451 70406044
Graft versus host disease 54.54 10.05 15 460934 15008 70452487
Paranasal sinus discomfort 54.51 10.05 89 460860 3446 70464049
Respiratory failure 54.35 10.05 1459 459490 167276 70300219
Haemophagocytic lymphohistiocytosis 54.07 10.05 30 460919 19582 70447913
Frustration tolerance decreased 53.83 10.05 129 460820 6636 70460859
Cardiotoxicity 53.61 10.05 5 460944 11065 70456430
Shock 53.56 10.05 114 460835 40311 70427184
Crepitations 52.75 10.05 150 460799 8564 70458931
Neuroleptic malignant syndrome 52.28 10.05 55 460894 25952 70441543
FEV1/FVC ratio decreased 51.31 10.05 25 460924 166 70467329
Knee arthroplasty 51.31 10.05 90 460859 34211 70433284
Sedation 51.05 10.05 496 460453 46235 70421260
Right atrial hypertrophy 50.76 10.05 38 460911 592 70466903
Hip arthroplasty 50.24 10.05 65 460884 27975 70439520
Enthesopathy 49.85 10.05 6 460943 10863 70456632
Increased upper airway secretion 49.45 10.05 88 460861 3657 70463838
Respiratory tract inflammation 49.38 10.05 42 460907 793 70466702
Appendicolith 49.23 10.05 112 460837 5568 70461927
Lung diffusion test abnormal 49.13 10.05 27 460922 237 70467258
Gastrointestinal disorder 49.04 10.05 443 460506 104984 70362511
Depression 48.88 10.05 1664 459285 197310 70270185
Panniculitis 48.70 10.05 6 460943 10670 70456825
Rubber sensitivity 48.34 10.05 54 460895 1441 70466054
Polyneuropathy 48.07 10.05 41 460908 21374 70446121
Animal scratch 48.05 10.05 48 460901 1122 70466373
Cardiac arrest 47.89 10.05 740 460209 159094 70308401
Rash maculo-papular 47.20 10.05 169 460780 50376 70417119
Infective exacerbation of chronic obstructive airways disease 46.81 10.05 69 460880 2442 70465053
Liver disorder 46.79 10.05 223 460726 61345 70406150
Blood pressure increased 46.42 10.05 1577 459372 186940 70280555
Gamma-glutamyltransferase increased 46.31 10.05 171 460778 50514 70416981
Extrapyramidal disorder 46.25 10.05 40 460909 20710 70446785
Joint range of motion decreased 45.94 10.05 61 460888 25965 70441530
Sputum abnormal 45.85 10.05 45 460904 1029 70466466
Migraine 45.62 10.05 691 460258 71547 70395948
Nasal inflammation 45.61 10.05 36 460913 609 70466886
Limb injury 45.43 10.05 305 460644 25447 70442048
Prolonged expiration 45.01 10.05 43 460906 950 70466545
Proteinuria 44.91 10.05 76 460873 29298 70438197
Night sweats 44.50 10.05 457 460492 43227 70424268
Cognitive disorder 44.45 10.05 598 460351 60358 70407137
Product complaint 44.20 10.05 177 460772 12054 70455441
Airway remodelling 43.43 10.05 23 460926 186 70467309
Hypercapnia 43.43 10.05 136 460813 8193 70459302
Prescribed underdose 43.24 10.05 45 460904 21340 70446155
Dyspnoea at rest 42.87 10.05 119 460830 6700 70460795
Back pain 42.66 10.05 2163 458786 268989 70198506
Somnolence 42.50 10.05 1071 459878 214535 70252960
Seizure 42.45 10.05 858 460091 177104 70290391
Colitis 42.39 10.05 242 460707 63572 70403923
Infection 42.37 10.05 1044 459905 209741 70257754
Tenosynovitis 42.11 10.05 19 460930 13957 70453538
Tumour lysis syndrome 42.02 10.05 46 460903 21314 70446181
Cytomegalovirus viraemia 41.80 10.05 12 460937 11673 70455822
Status epilepticus 41.77 10.05 59 460890 24467 70443028
Increased viscosity of bronchial secretion 41.62 10.05 31 460918 479 70467016
Shock haemorrhagic 41.46 10.05 34 460915 18072 70449423
Blood parathyroid hormone decreased 41.34 10.05 5 460944 9019 70458476
Incorrect dose administered 41.28 10.05 636 460313 66083 70401412
Aspirin-exacerbated respiratory disease 41.21 10.05 45 460904 1170 70466325
Emotional distress 40.76 10.05 395 460554 36793 70430702
Drug ineffective for unapproved indication 40.72 10.05 122 460827 38416 70429079
Hypercalcaemia 40.70 10.05 103 460846 34282 70433213
Constipation 40.59 10.05 2018 458931 250420 70217075
Drug hypersensitivity 40.58 10.05 1348 459601 261111 70206384
Nasal disorder 40.12 10.05 75 460874 3239 70464256
Pathogen resistance 40.09 10.05 18 460931 13261 70454234
Respiratory tract irritation 39.97 10.05 32 460917 553 70466942
Febrile bone marrow aplasia 39.90 10.05 14 460935 11977 70455518
Hyperammonaemia 39.84 10.05 9 460940 10284 70457211
Hyperbilirubinaemia 39.73 10.05 53 460896 22515 70444980
Herpes zoster 39.70 10.05 358 460591 84877 70382618
Painful respiration 39.33 10.05 73 460876 3135 70464360
Lymphopenia 38.94 10.05 74 460875 27285 70440210
Eye swelling 38.89 10.05 275 460674 23339 70444156
Product taste abnormal 38.82 10.05 58 460891 2078 70465417
Anosmia 38.73 10.05 93 460856 4790 70462705
Bradycardia 38.67 10.05 573 460376 124042 70343453
Chronic respiratory failure 38.42 10.05 66 460883 2666 70464829
Body temperature decreased 38.33 10.05 318 460631 28354 70439141
Polyp 38.24 10.05 118 460831 7052 70460443
Forced expiratory volume abnormal 38.04 10.05 18 460931 111 70467384
Alveolar osteitis 37.95 10.05 31 460918 552 70466943
Bradyphrenia 37.90 10.05 9 460940 9937 70457558
Sinus operation 37.62 10.05 55 460894 1932 70465563
Urinary tract discomfort 37.58 10.05 28 460921 433 70467062
Haemoglobin decreased 37.56 10.05 1030 459919 204129 70263366
Therapy partial responder 37.52 10.05 17 460932 12457 70455038
Hyperthermia 37.32 10.05 32 460917 16639 70450856
Inflammation 37.25 10.05 329 460620 78336 70389159
Diffuse large B-cell lymphoma 37.18 10.05 20 460929 13282 70454213
Insomnia 36.86 10.05 1750 459199 216056 70251439
Aphonia 36.79 10.05 138 460811 9113 70458382
Epstein-Barr virus infection 36.66 10.05 20 460929 13178 70454317
Exposure to allergen 36.63 10.05 22 460927 232 70467263
Spinal muscular atrophy 36.59 10.05 27 460922 411 70467084
Pulmonary congestion 36.35 10.05 284 460665 24870 70442625
Hyperkalaemia 36.32 10.05 481 460468 106110 70361385
Disorientation 36.18 10.05 224 460725 57699 70409796
Exercise tolerance decreased 36.16 10.05 127 460822 8121 70459374
Metabolic acidosis 36.07 10.05 309 460640 74037 70393458
Hepatic cytolysis 35.94 10.05 43 460906 19149 70448346
Aplasia 35.86 10.05 3 460946 7248 70460247
Acute hepatic failure 35.86 10.05 79 460870 27593 70439902
Factitious disorder 35.69 10.05 18 460931 130 70467365
Feeling abnormal 35.65 10.05 1193 459756 141126 70326369
Ulcer 35.50 10.05 71 460878 25683 70441812
Drug tolerance decreased 35.36 10.05 10 460939 9823 70457672
Drug level increased 35.35 10.05 120 460829 36349 70431146
Hiatus hernia 35.32 10.05 247 460702 20887 70446608
Rhinitis perennial 35.27 10.05 24 460925 319 70467176
Blood iron decreased 35.15 10.05 175 460774 13086 70454409
Cholecystitis chronic 34.94 10.05 137 460812 9239 70458256
Broncholithiasis 34.71 10.05 20 460929 194 70467301
Pharyngeal oedema 34.68 10.05 197 460752 15499 70451996
Bronchial neoplasm 34.59 10.05 27 460922 449 70467046
Congenital hiatus hernia 34.56 10.05 29 460920 537 70466958
Brain oedema 34.52 10.05 62 460887 23356 70444139
Skin necrosis 34.41 10.05 33 460916 16258 70451237
Hypertensive crisis 34.15 10.05 45 460904 19217 70448278
Bronchomalacia 34.03 10.05 20 460929 202 70467293
Hepatitis cholestatic 33.94 10.05 20 460929 12630 70454865
Rash erythematous 33.94 10.05 498 460451 51220 70416275
Multiple-drug resistance 33.88 10.05 4 460945 7351 70460144
Transplant dysfunction 33.79 10.05 3 460946 6906 70460589
Pruritus 33.73 10.05 2645 458304 342915 70124580
Nightmare 33.61 10.05 253 460696 21903 70445592
Akathisia 33.61 10.05 19 460930 12274 70455221
Wolff-Parkinson-White syndrome 33.60 10.05 22 460927 273 70467222
Intentional self-injury 33.58 10.05 100 460849 31550 70435945
Leukoencephalopathy 33.52 10.05 4 460945 7290 70460205
Intentional product misuse 33.39 10.05 343 460606 79252 70388243
Panic attack 33.23 10.05 252 460697 21867 70445628
Metastases to bone 33.20 10.05 59 460890 22317 70445178
Blood cholesterol increased 32.93 10.05 265 460684 64339 70403156
Atelectasis 32.92 10.05 310 460639 28652 70438843
Psoriasis 32.88 10.05 446 460503 97987 70369508
Peritonitis 32.83 10.05 76 460873 26083 70441412
Product use in unapproved indication 32.67 10.05 1063 459886 206415 70261080
Acute graft versus host disease in skin 32.58 10.05 4 460945 7133 70460362
Transaminases increased 32.49 10.05 176 460773 46842 70420653
Sputum retention 32.49 10.05 36 460913 952 70466543
Rheumatoid nodule 32.43 10.05 30 460919 15037 70452458
Enteritis 32.08 10.05 22 460927 12809 70454686
Lung opacity 31.94 10.05 73 460876 3640 70463855
Right ventricular hypertrophy 31.93 10.05 43 460906 1397 70466098
Decreased activity 31.80 10.05 116 460833 7558 70459937
Lung neoplasm malignant 31.79 10.05 272 460677 24470 70443025
Paraesthesia oral 31.79 10.05 190 460759 15227 70452268
Cockroach allergy 31.77 10.05 15 460934 92 70467403
Depressed mood 31.58 10.05 429 460520 43391 70424104
Hypoalbuminaemia 31.58 10.05 47 460902 19075 70448420
Rhinovirus infection 31.55 10.05 106 460843 6627 70460868
Hyper IgE syndrome 31.46 10.05 26 460923 471 70467024
Nephrectomy 31.41 10.05 48 460901 1755 70465740
Neurodevelopmental disorder 31.40 10.05 12 460937 39 70467456
Blood creatine phosphokinase increased 31.36 10.05 251 460698 61012 70406483
Diastolic dysfunction 31.32 10.05 133 460816 9300 70458195
Idiopathic intracranial hypertension 31.27 10.05 62 460887 2799 70464696
Multiple drug therapy 31.13 10.05 66 460883 3126 70464369
Nephropathy toxic 31.07 10.05 45 460904 18469 70449026
Mucormycosis 31.04 10.05 7 460942 8007 70459488
Immunodeficiency 31.02 10.05 208 460741 17347 70450148
Epilepsy 30.94 10.05 138 460811 38646 70428849
Kidney transplant rejection 30.87 10.05 13 460936 9948 70457547
Oesophageal spasm 30.84 10.05 65 460884 3066 70464429
Metastases to lung 30.80 10.05 37 460912 16447 70451048
Lower respiratory tract infection bacterial 30.65 10.05 33 460916 844 70466651
Cystitis haemorrhagic 30.42 10.05 9 460940 8584 70458911
Mouth swelling 30.38 10.05 90 460859 5259 70462236
Cardiac disorder 30.37 10.05 549 460400 58866 70408629
Hypersensitivity 30.35 10.05 1804 459145 228008 70239487
Ataxia 30.32 10.05 66 460883 23151 70444344
Unintentional medical device removal 30.17 10.05 5 460944 7119 70460376
Klebsiella infection 30.13 10.05 29 460920 14263 70453232
Nasal septum deviation 30.08 10.05 45 460904 1614 70465881
Distal intestinal obstruction syndrome 30.05 10.05 29 460920 649 70466846
Suspected suicide 29.94 10.05 10 460939 8824 70458671
Basal cell carcinoma 29.93 10.05 115 460834 33583 70433912
Hepatitis B 29.65 10.05 8 460941 8106 70459389
Atopy 29.40 10.05 21 460928 303 70467192
Salpingo-oophorectomy unilateral 29.37 10.05 28 460921 617 70466878
Alanine aminotransferase abnormal 29.34 10.05 8 460941 8051 70459444
Rebound nasal congestion 29.25 10.05 10 460939 21 70467474
Mycotic allergy 29.24 10.05 36 460913 1068 70466427
Prostate cancer 29.22 10.05 104 460845 31059 70436436
Blood pressure fluctuation 29.19 10.05 244 460705 58768 70408727
Multiple sclerosis relapse 29.18 10.05 162 460787 42855 70424640
Pulmonary toxicity 29.08 10.05 17 460932 10781 70456714
BK virus infection 28.96 10.05 8 460941 7981 70459514
Psychotic disorder 28.38 10.05 137 460812 37564 70429931
Blood bilirubin increased 28.15 10.05 251 460698 59650 70407845
Accidental exposure to product 28.08 10.05 91 460858 27960 70439535
Uveitis 28.08 10.05 33 460916 14812 70452683
Breast cancer stage III 27.61 10.05 5 460944 6676 70460819
Subarachnoid haemorrhage 27.55 10.05 53 460896 19451 70448044
Eosinophil count 27.43 10.05 14 460935 104 70467391
Nausea 27.40 10.05 4999 455950 847089 69620406
Subdural haematoma 27.32 10.05 98 460851 29200 70438295
Hypertransaminasaemia 27.19 10.05 12 460937 8931 70458564
Lung diffusion disorder 27.17 10.05 15 460934 133 70467362
Victim of child abuse 27.16 10.05 32 460917 906 70466589
Use of accessory respiratory muscles 27.06 10.05 22 460927 389 70467106
Oliguria 26.85 10.05 35 460914 15016 70452479
Delirium 26.78 10.05 333 460616 74281 70393214
Aplastic anaemia 26.73 10.05 42 460907 16674 70450821
Toxic skin eruption 26.59 10.05 57 460892 20105 70447390
Skin toxicity 26.48 10.05 7 460942 7191 70460304
Renal tubular necrosis 26.21 10.05 71 460878 23100 70444395
Skin ulcer 26.17 10.05 194 460755 47951 70419544
Hyposmia 26.12 10.05 26 460923 605 70466890
Generalised tonic-clonic seizure 26.08 10.05 161 460788 41500 70425995
Weight decreased 25.77 10.05 2348 458601 308140 70159355
Pickwickian syndrome 25.66 10.05 22 460927 420 70467075
Carbon dioxide increased 25.66 10.05 47 460902 1998 70465497
Femur fracture 25.66 10.05 134 460815 35998 70431497
Dehydration 25.48 10.05 1205 459744 224937 70242558
Aphthous ulcer 25.21 10.05 35 460914 14621 70452874
Influenza B virus test positive 25.21 10.05 20 460929 341 70467154
Crying 25.14 10.05 229 460720 20970 70446525
Sinusitis fungal 25.01 10.05 47 460902 2038 70465457
Dizziness 24.93 10.05 3411 457538 460730 70006765
Sepsis 24.86 10.05 1317 459632 243228 70224267
Ejection fraction decreased 24.81 10.05 109 460840 30653 70436842
Stoma closure 24.79 10.05 18 460931 267 70467228
Stridor 24.75 10.05 81 460868 4995 70462500
Osteomyelitis 24.71 10.05 107 460842 30211 70437284
Pulmonary embolism 24.61 10.05 1244 459705 154623 70312872
Foreign body in reproductive tract 24.45 10.05 22 460927 449 70467046
Hepatitis B reactivation 24.45 10.05 3 460946 5352 70462143
Osteoporosis 24.33 10.05 450 460499 48457 70419038
Haemolytic anaemia 24.28 10.05 45 460904 16749 70450746
Blood alkaline phosphatase increased 24.21 10.05 253 460696 58268 70409227
Type 2 diabetes mellitus 24.21 10.05 412 460537 43668 70423827
Hepatic cirrhosis 24.12 10.05 110 460839 30621 70436874
Superinfection 24.11 10.05 71 460878 4135 70463360
Oxygen consumption increased 24.02 10.05 76 460873 4604 70462891
Colitis ulcerative 23.98 10.05 126 460823 33797 70433698
Jaundice 23.97 10.05 209 460740 49899 70417596
Ventricular failure 23.97 10.05 23 460926 511 70466984
Enterococcal infection 23.93 10.05 36 460913 14546 70452949
Cardiac failure congestive 23.68 10.05 1092 459857 134365 70333130
Cytopenia 23.67 10.05 48 460901 17275 70450220
Forced expiratory volume 23.64 10.05 12 460937 88 70467407
Dermatitis allergic 23.46 10.05 185 460764 16246 70451249
Nystagmus 23.44 10.05 16 460933 9339 70458156
Rectal prolapse 23.43 10.05 45 460904 1984 70465511
Fracture 23.41 10.05 60 460889 19884 70447611
Squamous cell carcinoma of skin 23.26 10.05 29 460920 12683 70454812
Endometrial ablation 23.24 10.05 28 460921 812 70466683
Pregnancy 23.22 10.05 78 460871 23703 70443792
Sinus tachycardia 23.22 10.05 329 460620 33584 70433911
Tunnel vision 23.20 10.05 34 460915 1197 70466298
Drug dependence 23.17 10.05 356 460593 36965 70430530
Hypoacusis 23.06 10.05 275 460674 26994 70440501
Uterine perforation 22.70 10.05 87 460862 5804 70461691
Forced expiratory volume increased 22.53 10.05 9 460940 34 70467461
Osteonecrosis 22.52 10.05 105 460844 29055 70438440
Respiratory syncytial virus bronchiolitis 22.50 10.05 21 460928 450 70467045
Haemorrhage intracranial 22.37 10.05 84 460865 24693 70442802
Breast cancer stage I 22.33 10.05 6 460943 6096 70461399
Rib deformity 22.21 10.05 14 460935 162 70467333
Rash 22.20 10.05 2943 458006 507619 69959876
Dermatitis exfoliative generalised 22.20 10.05 7 460942 6407 70461088
Blood cholesterol 22.17 10.05 23 460926 563 70466932
Anger 22.14 10.05 180 460769 15952 70451543
Respiratory acidosis 22.03 10.05 128 460821 10153 70457342
Pancreatic carcinoma 22.01 10.05 31 460918 12873 70454622
Haematochezia 21.99 10.05 338 460611 72743 70394752
Stress cardiomyopathy 21.93 10.05 124 460825 9738 70457757
Cytomegalovirus chorioretinitis 21.82 10.05 4 460945 5294 70462201
Oral candidiasis 21.71 10.05 253 460696 24699 70442796
Cystic fibrosis related diabetes 21.69 10.05 15 460934 205 70467290
Musculoskeletal pain 21.67 10.05 435 460514 89892 70377603
Nasal oedema 21.65 10.05 34 460915 1273 70466222
Gastric cancer 21.54 10.05 16 460933 8939 70458556
Myoclonus 21.49 10.05 93 460856 26262 70441233
Psychomotor retardation 21.46 10.05 5 460944 5593 70461902
Graft versus host disease in gastrointestinal tract 21.46 10.05 6 460943 5938 70461557
Ear congestion 21.42 10.05 47 460902 2280 70465215
Nervousness 21.34 10.05 302 460647 30818 70436677
Asthma exercise induced 21.31 10.05 12 460937 111 70467384
Cervix neoplasm 21.23 10.05 14 460935 176 70467319
Product use issue 21.23 10.05 954 459995 178983 70288512
Blood immunoglobulin E decreased 21.08 10.05 11 460938 86 70467409
Disease complication 21.07 10.05 71 460878 4446 70463049
Bronchitis bacterial 21.06 10.05 34 460915 1304 70466191
Foreign body aspiration 21.03 10.05 17 460932 298 70467197
Exposure to toxic agent 21.01 10.05 7 460942 6187 70461308
Respiratory syncytial virus infection 20.99 10.05 102 460847 7553 70459942
Joint stiffness 20.96 10.05 138 460811 35038 70432457
Decreased bronchial secretion 20.96 10.05 10 460939 63 70467432
Toxic encephalopathy 20.92 10.05 22 460927 10384 70457111
Bladder cancer 20.91 10.05 51 460898 17191 70450304
Bronchial irritation 20.88 10.05 9 460940 43 70467452
Adverse event 20.80 10.05 213 460736 49248 70418247
Malignant mediastinal neoplasm 20.75 10.05 27 460922 848 70466647
Sleep disorder 20.74 10.05 598 460351 69274 70398221
Aplasia pure red cell 20.74 10.05 11 460938 7363 70460132
Separation anxiety disorder 20.49 10.05 8 460941 28 70467467
Oropharyngeal discomfort 20.41 10.05 86 460863 5993 70461502
Bacterial disease carrier 20.41 10.05 30 460919 1059 70466436
Drug use disorder 20.34 10.05 14 460935 8137 70459358
Nasal pruritus 20.33 10.05 19 460930 408 70467087
Central obesity 20.31 10.05 37 460912 1566 70465929
Lupus-like syndrome 20.31 10.05 27 460922 11488 70456007
Suffocation feeling 20.30 10.05 37 460912 1567 70465928
Temperature intolerance 20.28 10.05 111 460838 8612 70458883
Mydriasis 20.21 10.05 47 460902 16106 70451389
Breast cancer female 20.17 10.05 23 460926 10463 70457032
Ileus 20.09 10.05 85 460864 24152 70443343
Hepatocellular carcinoma 20.06 10.05 22 460927 10186 70457309
Anal abscess 20.02 10.05 15 460934 8343 70459152
Respiratory arrest 20.00 10.05 239 460710 53694 70413801
Lymphoproliferative disorder 19.96 10.05 5 460944 5324 70462171
Pemphigoid 19.89 10.05 38 460911 13984 70453511
Enterocolitis 19.80 10.05 34 460915 13032 70454463
Graft versus host disease in skin 19.74 10.05 6 460943 5624 70461871
Vocal cord disorder 19.73 10.05 34 460915 1377 70466118
Eosinophilic oesophagitis 19.66 10.05 20 460929 478 70467017
Sputum culture positive 19.59 10.05 57 460892 3297 70464198
Acute lymphocytic leukaemia recurrent 19.57 10.05 4 460945 4900 70462595
Coagulopathy 19.53 10.05 131 460818 33118 70434377
Wrong technique in device usage process 19.45 10.05 57 460892 3311 70464184
Arthritis bacterial 19.43 10.05 15 460934 8218 70459277
Injection site scab 19.43 10.05 17 460932 334 70467161
Snoring 19.37 10.05 73 460876 4831 70462664
Embolism venous 19.33 10.05 62 460887 3783 70463712
Acute respiratory distress syndrome 19.32 10.05 173 460776 41081 70426414
Device related infection 19.31 10.05 126 460823 32059 70435436
Haemophilus infection 19.28 10.05 41 460908 1946 70465549
Tachypnoea 19.28 10.05 277 460672 28361 70439134
Attention-seeking behaviour 19.24 10.05 11 460938 105 70467390
Metastases to lymph nodes 19.18 10.05 19 460930 9219 70458276
Gallbladder injury 19.13 10.05 30 460919 1122 70466373
Inappropriate antidiuretic hormone secretion 19.06 10.05 82 460867 23194 70444301
Product administered to patient of inappropriate age 19.06 10.05 72 460877 4771 70462724
Soft tissue mass 19 10.05 29 460920 1059 70466436
Drug level decreased 18.99 10.05 33 460916 12591 70454904
Angle closure glaucoma 18.98 10.05 50 460899 2729 70464766
Hypocalcaemia 18.94 10.05 193 460756 44666 70422829
Stevens-Johnson syndrome 18.90 10.05 146 460803 35761 70431734
Peripheral sensory neuropathy 18.82 10.05 31 460918 12079 70455416
Total lung capacity abnormal 18.78 10.05 13 460936 178 70467317
Neutropenic colitis 18.77 10.05 5 460944 5109 70462386
Parathyroid gland enlargement 18.74 10.05 12 460937 143 70467352
Skin candida 18.69 10.05 38 460911 1747 70465748
Respiratory gas exchange disorder 18.68 10.05 24 460925 744 70466751
Foot deformity 18.66 10.05 70 460879 20585 70446910
Sinus polyp 18.65 10.05 19 460930 455 70467040
Oxygen therapy 18.58 10.05 46 460903 2416 70465079
Grip strength decreased 18.55 10.05 47 460902 15638 70451857
Erythema multiforme 18.55 10.05 51 460898 16513 70450982
Exostosis 18.55 10.05 41 460908 14304 70453191
Pulmonary pain 18.49 10.05 57 460892 3405 70464090
Substance abuse 18.46 10.05 22 460927 9815 70457680
Bronchopulmonary aspergillosis 18.44 10.05 72 460877 20930 70446565
Incorrect dose administered by product 18.41 10.05 13 460936 184 70467311
Bronchial haemorrhage 18.33 10.05 31 460918 1236 70466259
Muscle rigidity 18.32 10.05 61 460888 18589 70448906
Ischaemic stroke 18.32 10.05 121 460828 30699 70436796
Retinal haemorrhage 18.26 10.05 14 460935 7696 70459799
Breast cancer stage II 18.21 10.05 6 460943 5340 70462155
Colitis microscopic 18.15 10.05 19 460930 8986 70458509
Pneumothorax spontaneous 18.13 10.05 32 460917 1321 70466174
Carpal tunnel syndrome 18.12 10.05 180 460769 16877 70450618
Injection site reaction 18.07 10.05 222 460727 49630 70417865
Nicotine dependence 18.06 10.05 25 460924 834 70466661
Hyperuricaemia 18.06 10.05 27 460922 10939 70456556
Right atrial enlargement 18.05 10.05 16 460933 320 70467175
Small airways disease 18.04 10.05 7 460942 24 70467471
Lip discolouration 17.99 10.05 22 460927 648 70466847
Gastroenteritis viral 17.98 10.05 216 460733 21239 70446256
Endometriosis 17.96 10.05 54 460895 3182 70464313
Feeling cold 17.88 10.05 249 460700 25321 70442174
Lacrimation increased 17.86 10.05 203 460746 19696 70447799
Hepatitis toxic 17.84 10.05 4 460945 4595 70462900
Hypothermia 17.83 10.05 71 460878 20523 70446972
Pulmonary hypertension 17.82 10.05 412 460537 46124 70421371
Nasal mucosal discolouration 17.82 10.05 7 460942 25 70467470
Pneumonia lipoid 17.73 10.05 12 460937 158 70467337
Nephrotic syndrome 17.72 10.05 26 460923 10614 70456881
Cor pulmonale 17.71 10.05 41 460908 2062 70465433
Brain injury 17.69 10.05 124 460825 10493 70457002
Thunderclap headache 17.68 10.05 14 460935 238 70467257
Venoocclusive disease 17.67 10.05 3 460946 4197 70463298
Familial periodic paralysis 17.66 10.05 12 460937 159 70467336
Croup infectious 17.65 10.05 21 460928 601 70466894
Pulmonary tuberculosis 17.63 10.05 15 460934 7830 70459665
Peak expiratory flow rate abnormal 17.62 10.05 10 460939 94 70467401
Renal cancer 17.60 10.05 31 460918 11765 70455730
Ear discomfort 17.53 10.05 97 460852 7557 70459938
Pseudomonal sepsis 17.53 10.05 7 460942 5530 70461965
Pharyngeal erythema 17.52 10.05 38 460911 1829 70465666
Myalgia 17.50 10.05 1292 459657 166600 70300895
Nocturnal dyspnoea 17.49 10.05 32 460917 1359 70466136
Cholestatic liver injury 17.49 10.05 3 460946 4165 70463330
Pneumonia pseudomonal 17.44 10.05 74 460875 5172 70462323
Heart sounds 17.44 10.05 23 460926 732 70466763
Electrocardiogram QRS complex prolonged 17.29 10.05 23 460926 9783 70457712
Sinonasal obstruction 17.25 10.05 14 460935 247 70467248
Influenza like illness 17.21 10.05 551 460398 64780 70402715
Blood urea increased 17.19 10.05 203 460746 45706 70421789
Autoimmune haemolytic anaemia 17.18 10.05 15 460934 7731 70459764
Wrong patient received product 17.18 10.05 4 460945 4476 70463019
Gastric haemorrhage 17.17 10.05 42 460907 14143 70453352
Intentional device misuse 17.15 10.05 22 460927 681 70466814
Injury 17.12 10.05 550 460399 64695 70402800
Functional residual capacity increased 17.08 10.05 9 460940 72 70467423
Appetite disorder 16.93 10.05 90 460859 6905 70460590
Visual acuity reduced 16.93 10.05 109 460840 27821 70439674
Tooth disorder 16.87 10.05 89 460860 23849 70443646
Labelled drug-drug interaction medication error 16.84 10.05 90 460859 24037 70443458
Magnetic resonance imaging thoracic abnormal 16.84 10.05 6 460943 15 70467480
Motor neurone disease 16.79 10.05 20 460929 573 70466922
Hepatic cancer 16.78 10.05 23 460926 9660 70457835
Hypertriglyceridaemia 16.76 10.05 32 460917 11779 70455716
Jaundice cholestatic 16.75 10.05 21 460928 9163 70458332
Pharyngitis streptococcal 16.72 10.05 112 460837 9336 70458159
Haemolysis 16.65 10.05 31 460918 11520 70455975
Endophthalmitis 16.63 10.05 10 460939 6245 70461250
Encephalitis 16.62 10.05 40 460909 13545 70453950
Mixed liver injury 16.60 10.05 10 460939 6239 70461256
Device defective 16.59 10.05 33 460916 1493 70466002
Device ineffective 16.57 10.05 11 460938 140 70467355
Expired product administered 16.55 10.05 84 460865 6329 70461166
Cystic fibrosis lung 16.50 10.05 11 460938 141 70467354
Functional residual capacity decreased 16.47 10.05 9 460940 78 70467417
Complications of transplanted kidney 16.47 10.05 9 460940 5925 70461570
Bacteraemia 16.46 10.05 117 460832 29192 70438303
Tuberculosis 16.42 10.05 46 460903 14802 70452693
Dyskinesia 16.41 10.05 179 460770 40895 70426600
Breast conserving surgery 16.35 10.05 21 460928 651 70466844
Allergic cough 16.35 10.05 19 460930 530 70466965
Bed bug infestation 16.31 10.05 5 460944 6 70467489
Hyperhidrosis 16.25 10.05 1027 459922 130559 70336936
PCO2 increased 16.23 10.05 35 460914 1678 70465817
Biliary dyskinesia 16.22 10.05 43 460906 2356 70465139
Influenza immunisation 16.17 10.05 4 460945 0 70467495
International normalised ratio increased 16.15 10.05 400 460549 80326 70387169
Urinary tract infection 16.15 10.05 1394 459555 247375 70220120
Pneumococcal sepsis 16.15 10.05 32 460917 1444 70466051
Tracheal disorder 16.13 10.05 17 460932 424 70467071
Adenovirus infection 16.10 10.05 16 460933 7752 70459743
Acute generalised exanthematous pustulosis 16.08 10.05 49 460900 15348 70452147
Hemiparesis 16.07 10.05 129 460820 31340 70436155
Self-injurious ideation 16.04 10.05 53 460896 3285 70464210
Ileus paralytic 16.01 10.05 20 460929 8741 70458754
Increased viscosity of upper respiratory secretion 16.00 10.05 14 460935 275 70467220
Acute lymphocytic leukaemia 16.00 10.05 8 460941 5537 70461958
Gastrointestinal toxicity 15.99 10.05 11 460938 6394 70461101
Bacterial tracheitis 15.98 10.05 7 460942 35 70467460
Electrocardiogram U-wave abnormality 15.91 10.05 9 460940 84 70467411
Infective exacerbation of bronchiectasis 15.85 10.05 22 460927 736 70466759
Oesophageal polyp 15.84 10.05 8 460941 58 70467437
Encephalitis toxic 15.84 10.05 14 460935 279 70467216
Cytomegalovirus test positive 15.81 10.05 8 460941 5500 70461995
Tremor 15.78 10.05 1195 459754 154429 70313066
Brain abscess 15.77 10.05 5 460944 4561 70462934
Dermatitis acneiform 15.75 10.05 21 460928 8924 70458571
Spinal pain 15.72 10.05 42 460907 13728 70453767
Decreased gait velocity 15.68 10.05 11 460938 154 70467341
Tongue pruritus 15.63 10.05 18 460931 497 70466998
Anal fistula 15.63 10.05 10 460939 6040 70461455
Vascular shunt 15.52 10.05 7 460942 38 70467457
Second primary malignancy 15.52 10.05 39 460910 13012 70454483
Cerebral haematoma 15.52 10.05 15 460934 7363 70460132
Exposure to fungus 15.49 10.05 10 460939 121 70467374
Acute graft versus host disease in intestine 15.46 10.05 3 460946 3813 70463682
Allergic sinusitis 15.46 10.05 18 460931 503 70466992
Intervertebral discitis 15.40 10.05 4 460945 4157 70463338
Retinitis 15.39 10.05 4 460945 4156 70463339
Miosis 15.36 10.05 44 460905 14057 70453438
Obesity 15.35 10.05 252 460697 26519 70440976
Condition aggravated 15.24 10.05 2494 458455 425141 70042354
Muscle spasms 15.14 10.05 1180 459769 152866 70314629
Hyperpyrexia 15.14 10.05 8 460941 5366 70462129
Product cleaning inadequate 15.12 10.05 5 460944 9 70467486
Paranasal sinus hypersecretion 15.06 10.05 52 460897 3297 70464198
Mycobacterium test positive 14.99 10.05 16 460933 405 70467090
Sarcopenia 14.93 10.05 16 460933 407 70467088
Oropharyngitis fungal 14.87 10.05 8 460941 67 70467428
Haemodynamic instability 14.85 10.05 52 460897 15606 70451889
Mood swings 14.85 10.05 183 460766 18103 70449392
Gingival bleeding 14.84 10.05 50 460899 15182 70452313
Eosinophilic pneumonia chronic 14.77 10.05 17 460932 469 70467026
Neurosensory hypoacusis 14.77 10.05 12 460937 212 70467283
Upper respiratory fungal infection 14.70 10.05 14 460935 308 70467187
Multimorbidity 14.64 10.05 27 460922 1154 70466341
Cardiac murmur 14.64 10.05 132 460817 12054 70455441
Epidural lipomatosis 14.63 10.05 24 460925 933 70466562
Facet joint syndrome 14.60 10.05 11 460938 6102 70461393
Benign prostatic hyperplasia 14.59 10.05 117 460832 10326 70457169
Accessory spleen 14.55 10.05 11 460938 174 70467321
Alcohol interaction 14.54 10.05 6 460943 4647 70462848
Hypothyroidism 14.53 10.05 395 460554 45360 70422135
Oesophageal pain 14.53 10.05 56 460893 3746 70463749
Bladder prolapse 14.51 10.05 28 460921 1239 70466256
Infusion site swelling 14.50 10.05 79 460870 6119 70461376
Emergency care examination 14.48 10.05 8 460941 71 70467424
Hyperventilation 14.46 10.05 88 460861 7098 70460397
Cerebellar syndrome 14.42 10.05 8 460941 5223 70462272
Duodenal ulcer repair 14.39 10.05 8 460941 72 70467423
Escherichia infection 14.33 10.05 56 460893 16275 70451220
Immune thrombocytopenia 14.31 10.05 56 460893 16268 70451227
Clostridium difficile colitis 14.29 10.05 120 460829 28876 70438619
Deep vein thrombosis postoperative 14.27 10.05 3 460946 3604 70463891
Renal injury 14.24 10.05 55 460894 16039 70451456
Tracheomalacia 14.22 10.05 12 460937 224 70467271
Blood immunoglobulin E abnormal 14.20 10.05 6 460943 27 70467468
Hydronephrosis 14.20 10.05 51 460898 15191 70452304
Squamous cell carcinoma 14.19 10.05 48 460901 14556 70452939
Deformity 14.09 10.05 20 460929 8277 70459218
Kyphosis 14.06 10.05 41 460908 2375 70465120
Red blood cell sedimentation rate abnormal 14.04 10.05 71 460878 19232 70448263
Cytomegalovirus colitis 13.95 10.05 5 460944 4221 70463274
Nocardiosis 13.92 10.05 8 460941 5121 70462374
Cell death 13.81 10.05 5 460944 4195 70463300
Hypotension 13.80 10.05 2364 458585 402017 70065478
Schizophrenia 13.78 10.05 59 460890 16709 70450786
Cortisol decreased 13.73 10.05 35 460914 1872 70465623
Restlessness 13.66 10.05 192 460757 41936 70425559
Accidental overdose 13.66 10.05 154 460795 34967 70432528
Exposure during pregnancy 13.65 10.05 450 460499 87267 70380228
Cerebral artery thrombosis 13.64 10.05 25 460924 1063 70466432
Hypopnoea 13.63 10.05 51 460898 3364 70464131
Haematuria 13.55 10.05 312 460637 63261 70404234
Varicella zoster gastritis 13.54 10.05 6 460943 31 70467464
Metastases to peritoneum 13.52 10.05 4 460945 3815 70463680
Neurological decompensation 13.51 10.05 7 460942 4749 70462746
Ear infection 13.50 10.05 259 460690 28077 70439418
Burns third degree 13.47 10.05 15 460934 399 70467096
Central nervous system lesion 13.46 10.05 39 460910 12414 70455081
Oxygen saturation 13.46 10.05 12 460937 242 70467253
Inspiratory capacity abnormal 13.43 10.05 8 460941 83 70467412
Brain scan abnormal 13.38 10.05 26 460923 1156 70466339
Nasal turbinate abnormality 13.38 10.05 5 460944 15 70467480
Metastasis 13.37 10.05 12 460937 6102 70461393
Renal tubular disorder 13.35 10.05 12 460937 6098 70461397
Diaphragmatic disorder 13.31 10.05 31 460918 1565 70465930
Complication of device removal 13.30 10.05 51 460898 3403 70464092
Body mass index increased 13.26 10.05 33 460916 1739 70465756
Fungal disease carrier 13.25 10.05 13 460936 297 70467198
Colon cancer 13.24 10.05 48 460901 14258 70453237
Suicidal ideation 13.24 10.05 566 460383 69030 70398465
Reversible cerebral vasoconstriction syndrome 13.23 10.05 43 460906 2642 70464853
Overweight 13.23 10.05 52 460897 3511 70463984
Eye allergy 13.22 10.05 18 460931 591 70466904
Haematoma 13.22 10.05 228 460721 48190 70419305
Meningitis 13.21 10.05 23 460926 8770 70458725
Vertigo 13.19 10.05 308 460641 62335 70405160
Pneumonia aspiration 13.19 10.05 306 460643 61983 70405512
Tongue disorder 13.18 10.05 43 460906 13184 70454311
Infusion site erythema 13.14 10.05 89 460860 7446 70460049
Erysipelas 13.13 10.05 28 460921 9896 70457599
Gait disturbance 13.11 10.05 1030 459919 184076 70283419
Factor V Leiden mutation 13.03 10.05 10 460939 162 70467333
Hypoglycaemic coma 13.03 10.05 6 460943 4355 70463140
Anti-cyclic citrullinated peptide antibody 13.02 10.05 3 460946 3382 70464113
Herpes simplex 13.02 10.05 34 460915 11198 70456297
Subileus 13.02 10.05 9 460940 5218 70462277
Ill-defined disorder 13.01 10.05 264 460685 54477 70413018
Grunting 12.94 10.05 15 460934 417 70467078
Ankylosing spondylitis 12.94 10.05 36 460913 11610 70455885
Sinus bradycardia 12.93 10.05 95 460854 23528 70443967
Metastases to central nervous system 12.91 10.05 52 460897 14982 70452513
Urinary retention 12.87 10.05 252 460697 52268 70415227
Cholecystectomy 12.87 10.05 97 460852 8400 70459095
Red blood cell count decreased 12.87 10.05 250 460699 51911 70415584
Gastrointestinal haemorrhage 12.85 10.05 746 460203 136662 70330833
Skin erosion 12.84 10.05 5 460944 4011 70463484
Upper respiratory tract congestion 12.80 10.05 39 460910 2315 70465180
Mucosal discolouration 12.77 10.05 20 460929 747 70466748
Bursitis 12.77 10.05 244 460705 26429 70441066
Cutaneous vasculitis 12.74 10.05 17 460932 7221 70460274
Social avoidant behaviour 12.74 10.05 62 460887 4594 70462901
Acute sinusitis 12.72 10.05 58 460891 4183 70463312
Ventricular hyperkinesia 12.71 10.05 12 460937 261 70467234
Therapeutic response decreased 12.70 10.05 286 460663 58167 70409328
Meningitis cryptococcal 12.70 10.05 3 460946 3325 70464170
Right ventricular systolic pressure 12.70 10.05 5 460944 18 70467477
Lung hernia 12.68 10.05 7 460942 62 70467433
Renal artery stent placement 12.68 10.05 6 460943 37 70467458
Immune effector cell-associated neurotoxicity syndrome 12.64 10.05 5 460944 3973 70463522
Respiratory tract infection bacterial 12.63 10.05 32 460917 1705 70465790
Bladder pain 12.63 10.05 35 460914 1969 70465526
Musculoskeletal chest pain 12.61 10.05 214 460735 22667 70444828
Musculoskeletal disorder 12.59 10.05 77 460872 19894 70447601
CFTR gene mutation 12.59 10.05 8 460941 94 70467401
Mood altered 12.58 10.05 163 460786 16312 70451183
Vaccination site warmth 12.54 10.05 4 460945 6 70467489
Breath alcohol test positive 12.54 10.05 4 460945 6 70467489
Granulocytopenia 12.52 10.05 32 460917 10615 70456880
Choking sensation 12.50 10.05 52 460897 3603 70463892
Body temperature abnormal 12.46 10.05 34 460915 1895 70465600
Scleritis 12.45 10.05 4 460945 3618 70463877
Chest injury 12.33 10.05 41 460908 2550 70464945
Breast cancer metastatic 12.31 10.05 30 460919 10116 70457379
Urosepsis 12.31 10.05 98 460851 23851 70443644
Flour sensitivity 12.30 10.05 5 460944 20 70467475
Polymyalgia rheumatica 12.30 10.05 54 460895 3832 70463663
Accidental death 12.27 10.05 5 460944 3903 70463592
Essential hypertension 12.23 10.05 69 460880 5415 70462080
Ovarian hyperstimulation syndrome 12.21 10.05 3 460946 3237 70464258
Bronchitis chronic 12.21 10.05 56 460893 4048 70463447
Coronary artery stenosis 12.20 10.05 37 460912 11607 70455888
Wrist fracture 12.17 10.05 113 460836 10403 70457092
Peptic ulcer 12.16 10.05 71 460878 5642 70461853
Hilar lymphadenopathy 12.15 10.05 30 460919 1573 70465922
Breath sounds 12.14 10.05 9 460940 138 70467357
Dysarthria 12.13 10.05 310 460639 62003 70405492
Noninfective bronchitis 12.13 10.05 3 460946 0 70467495
Ventricular pre-excitation 12.13 10.05 3 460946 0 70467495
Monoparesis 12.12 10.05 3 460946 3221 70464274
Tendon calcification 12.09 10.05 9 460940 139 70467356
Peritonitis bacterial 12.08 10.05 26 460923 9158 70458337
Scoliosis 12.02 10.05 78 460871 6433 70461062
Oral pruritus 12.00 10.05 34 460915 1937 70465558
Pneumonectomy 11.97 10.05 7 460942 70 70467425
Infusion site mass 11.97 10.05 25 460924 1172 70466323
Aortic dissection 11.95 10.05 5 460944 3842 70463653
Nephrogenic systemic fibrosis 11.94 10.05 13 460936 6039 70461456
Impaired work ability 11.94 10.05 60 460889 16280 70451215
Carcinoid tumour pulmonary 11.91 10.05 13 460936 338 70467157
Cholangitis 11.89 10.05 37 460912 11512 70455983
Aptyalism 11.88 10.05 19 460930 723 70466772
Orthopnoea 11.86 10.05 103 460846 9305 70458190
Pyelonephritis acute 11.86 10.05 11 460938 5506 70461989
Vision blurred 11.84 10.05 742 460207 94242 70373253
Mitral valve thickening 11.84 10.05 14 460935 398 70467097
Respiratory tract infection viral 11.81 10.05 50 460899 3491 70464004
Personal relationship issue 11.79 10.05 10 460939 188 70467307
Overflow diarrhoea 11.78 10.05 8 460941 106 70467389
Panic reaction 11.77 10.05 57 460892 4214 70463281
Oxygen consumption decreased 11.75 10.05 14 460935 401 70467094
Oesophagogastroduodenoscopy 11.75 10.05 10 460939 189 70467306
Cyanosis 11.70 10.05 214 460735 22992 70444503
Diffuse large B-cell lymphoma recurrent 11.67 10.05 4 460945 3472 70464023
Procedural pain 11.65 10.05 173 460776 17836 70449659
Dizziness exertional 11.65 10.05 16 460933 530 70466965
Generalised anxiety disorder 11.64 10.05 34 460915 1971 70465524
Capillary leak syndrome 11.59 10.05 4 460945 3458 70464037
Trifascicular block 11.56 10.05 9 460940 149 70467346
Nasal dryness 11.54 10.05 52 460897 3731 70463764
Adverse reaction 11.54 10.05 24 460925 8558 70458937
Pneumonitis 11.53 10.05 449 460500 54148 70413347
Device failure 11.45 10.05 71 460878 5764 70461731
Sexual dysfunction 11.45 10.05 16 460933 6665 70460830
Macular oedema 11.44 10.05 10 460939 5152 70462343
Dermatitis exfoliative 11.44 10.05 33 460916 10518 70456977
Aortic aneurysm 11.44 10.05 89 460860 7784 70459711
Post-tussive vomiting 11.42 10.05 5 460944 25 70467470
Cervicogenic headache 11.42 10.05 5 460944 25 70467470
Loss of consciousness 11.41 10.05 864 460085 154852 70312643
Aphasia 11.38 10.05 205 460744 43044 70424451
Product availability issue 11.36 10.05 44 460905 2950 70464545
Pancreatitis 11.35 10.05 315 460634 62353 70405142
Ageusia 11.33 10.05 147 460802 14715 70452780
Cerebrovascular accident 11.33 10.05 791 460158 142679 70324816
Ejection fraction abnormal 11.31 10.05 31 460918 1732 70465763
Child abuse 11.26 10.05 13 460936 360 70467135
Atypical mycobacterial lower respiratory tract infection 11.25 10.05 7 460942 79 70467416
Pleural effusion 11.25 10.05 728 460221 132136 70335359
Quality of life decreased 11.24 10.05 94 460855 8401 70459094
Bronchitis haemophilus 11.23 10.05 4 460945 10 70467485
Guillain-Barre syndrome 11.22 10.05 22 460927 8018 70459477
Pseudomembranous colitis 11.21 10.05 10 460939 5101 70462394
Product administration error 11.19 10.05 261 460688 29262 70438233
Paraneoplastic rash 11.18 10.05 7 460942 80 70467415
Pneumonia cytomegaloviral 11.16 10.05 8 460941 4553 70462942
Adjusted calcium decreased 11.12 10.05 10 460939 204 70467291
Hypermetropia 11.07 10.05 14 460935 427 70467068
Myocarditis 11.06 10.05 74 460875 18719 70448776
Herpes virus infection 11.05 10.05 16 460933 6568 70460927
Hepatitis fulminant 11.04 10.05 16 460933 6565 70460930
Lactose intolerance 11.03 10.05 35 460914 2123 70465372
Delusion 11.01 10.05 76 460873 19089 70448406
Device expulsion 10.99 10.05 92 460857 22154 70445341
Blebitis 10.96 10.05 4 460945 11 70467484
Methaemoglobinaemia 10.94 10.05 9 460940 4777 70462718
Appendicitis 10.93 10.05 161 460788 16572 70450923
Thoracic haemorrhage 10.92 10.05 10 460939 209 70467286
Retinal artery occlusion 10.92 10.05 3 460946 3003 70464492
Flail chest 10.89 10.05 7 460942 84 70467411
Sinus headache 10.88 10.05 58 460891 4455 70463040
Acute coronary syndrome 10.87 10.05 81 460868 19998 70447497
Prescription drug used without a prescription 10.87 10.05 3 460946 2994 70464501
Hereditary angioedema 10.85 10.05 63 460886 4996 70462499
Chronic lymphocytic leukaemia 10.85 10.05 13 460936 5785 70461710
Bronchoscopy 10.82 10.05 7 460942 85 70467410
Product prescribing issue 10.80 10.05 44 460905 3020 70464475
Blood culture positive 10.79 10.05 22 460927 7904 70459591
Viral mutation identified 10.79 10.05 5 460944 3617 70463878
Vaccination site erythema 10.79 10.05 6 460943 54 70467441
Red cell distribution width abnormal 10.77 10.05 10 460939 213 70467282
Electrocardiogram QT shortened 10.77 10.05 10 460939 213 70467282
Cardiac tamponade 10.76 10.05 25 460924 8570 70458925
Ear pruritus 10.75 10.05 44 460905 3026 70464469
Hypervolaemia 10.75 10.05 336 460613 39370 70428125
Otitis media 10.75 10.05 69 460880 5670 70461825
Incorrect dose administered by device 10.73 10.05 57 460892 4372 70463123
Hernia pain 10.73 10.05 14 460935 441 70467054
Communication disorder 10.72 10.05 51 460898 3743 70463752
Catatonia 10.72 10.05 23 460926 8110 70459385
Atypical fracture 10.68 10.05 17 460932 644 70466851
Mycobacterial infection 10.68 10.05 48 460901 3440 70464055
Coordination abnormal 10.63 10.05 61 460888 16005 70451490
Weaning failure 10.60 10.05 17 460932 648 70466847
Stem cell transplant 10.60 10.05 5 460944 3580 70463915
Medication error 10.59 10.05 285 460664 56627 70410868
Endotracheal intubation 10.58 10.05 56 460893 4290 70463205
Staphylococcal sepsis 10.57 10.05 48 460901 13379 70454116
Intestinal perforation 10.57 10.05 61 460888 15983 70451512
Prothrombin time shortened 10.56 10.05 3 460946 2939 70464556
Paresis 10.55 10.05 6 460943 3864 70463631
Tobacco abuse 10.55 10.05 20 460929 873 70466622
School refusal 10.54 10.05 5 460944 31 70467464
End stage renal disease 10.54 10.05 37 460912 11096 70456399
Skin laceration 10.50 10.05 231 460718 25647 70441848
Rib fracture 10.50 10.05 227 460722 25129 70442366
Cardiac septal defect 10.45 10.05 11 460938 274 70467221
Tuberculin test positive 10.44 10.05 4 460945 3242 70464253
Product packaging quantity issue 10.44 10.05 23 460926 1119 70466376
Hospice care 10.44 10.05 90 460859 8115 70459380
Dyskinesia oesophageal 10.43 10.05 6 460943 58 70467437
Radioallergosorbent test positive 10.41 10.05 5 460944 32 70467463
Live birth 10.41 10.05 50 460899 13729 70453766
Back injury 10.40 10.05 95 460854 8707 70458788
Hypoglycaemia 10.38 10.05 504 460445 93860 70373635
Thrombotic thrombocytopenic purpura 10.38 10.05 15 460934 6162 70461333
Gastrointestinal perforation 10.35 10.05 13 460936 5668 70461827
Enterovirus infection 10.35 10.05 29 460920 1642 70465853
Airway peak pressure increased 10.34 10.05 12 460937 334 70467161
Lymphocyte count decreased 10.34 10.05 210 460739 43329 70424166
Hepatosplenomegaly 10.31 10.05 13 460936 5657 70461838
Deafness neurosensory 10.29 10.05 17 460932 6615 70460880
Resuscitation 10.26 10.05 36 460913 2301 70465194
Infusion site pruritus 10.26 10.05 45 460904 3192 70464303
Sarcoidosis 10.23 10.05 76 460873 6551 70460944
Symptom recurrence 10.22 10.05 26 460923 1389 70466106
Escherichia sepsis 10.22 10.05 21 460928 7522 70459973
Bone cyst 10.19 10.05 3 460946 2871 70464624
Infusion site rash 10.17 10.05 25 460924 1307 70466188
Tobacco user 10.14 10.05 17 460932 673 70466822
Concussion 10.13 10.05 92 460857 8417 70459078
Femoral neck fracture 10.11 10.05 28 460921 9045 70458450
Gait deviation 10.09 10.05 6 460943 62 70467433
Sleep disorder due to general medical condition, hypersomnia type 10.07 10.05 3 460946 3 70467492
Upper airway resistance syndrome 10.07 10.05 3 460946 3 70467492
Tracheal mass 10.07 10.05 3 460946 3 70467492

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03AK04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03CC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
FDA MoA N0000009922 Adrenergic beta2-Agonists
CHEBI has role CHEBI:35522 beta-adrenergic agonists
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D015149 Tocolytic Agents
FDA EPC N0000175779 beta2-Adrenergic Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchospasm indication 4386001
Acute exacerbation of asthma indication 708038006
Bronchospasm Prevention indication
Exercise-Induced Bronchospasm Prevention indication
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Ketoacidosis contraindication 56051008
Metabolic acidosis contraindication 59455009
Diabetes mellitus contraindication 73211009 DOID:9351
Paradoxical bronchospasm contraindication 102578005
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Myocardial ischemia contraindication 414795007 DOID:3393
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Immediate relief of bronchospasm and bronchoconstriction associated with reversible airway obstruction Indication

🐶 Veterinary products

ProductApplicantIngredients
Torpex Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.07 acidic
pKa2 9.46 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST Ki 5.95 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.61 PDSP
Beta-2 adrenergic receptor GPCR Kd 5.94 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.28 CHEMBL

External reference:

IDSource
4018796 VUID
N0000147099 NUI
D02147 KEGG_DRUG
51022-70-9 SECONDARY_CAS_RN
142153 RXNORM
C0001927 UMLSCUI
CHEBI:2549 CHEBI
68H PDB_CHEM_ID
CHEMBL714 ChEMBL_ID
DB01001 DRUGBANK_ID
CHEMBL1441059 ChEMBL_ID
CHEMBL1201026 ChEMBL_ID
2083 PUBCHEM_CID
558 IUPHAR_LIGAND_ID
QF8SVZ843E UNII
001814 NDDF
001815 NDDF
D000420 MESH_DESCRIPTOR_UI
2585 INN_ID
372897005 SNOMEDCT_US
48474002 SNOMEDCT_US
91143003 SNOMEDCT_US
4018796 VANDF
4018797 VANDF
3007 MMSL
30960 MMSL
4143 MMSL
4144 MMSL
46702 MMSL
d00749 MMSL

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0742 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) ANDA 14 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 26 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 26 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0254-1007 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0255 TABLET 2 mg ORAL ANDA 23 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0572 TABLET 4 mg ORAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6991 SOLUTION 0.63 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6991 SOLUTION 0.63 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6992 SOLUTION 1.25 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6992 SOLUTION 1.25 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-7057 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-7058 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-8270 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 24 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0378-9671 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0472-0825 SYRUP 2 mg ORAL ANDA 22 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0487-0201 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-0301 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9501 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9901 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9904 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3467 SOLUTION 0.63 mg INTRABRONCHIAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3468 SOLUTION 1.25 mg INTRABRONCHIAL ANDA 23 sections
Combivent Respimat HUMAN PRESCRIPTION DRUG LABEL 2 0597-0024 SPRAY, METERED 100 ug RESPIRATORY (INHALATION) NDA 27 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0781-7146 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7155 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7296 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections