salbutamol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 105 18559-94-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salbutamol
  • albuterol
  • sabumol
  • dl-Albuterol
  • dl-Salbutamol
  • albuterol sulfate
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
  • Molecular weight: 239.32
  • Formula: C13H21NO3
  • CLOGP: 0.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -2.05
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
10 mg Inhal.solution
12 mg O
12 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.23 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.92 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 1, 1981 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 7194.53 9.85 5843 343507 103129 52896587
Wheezing 2739.24 9.85 2715 346635 62560 52937156
Dyspnoea 2150.50 9.85 8529 340821 577703 52422013
Product quality issue 1431.15 9.85 1474 347876 35549 52964167
Chronic obstructive pulmonary disease 1325.51 9.85 1810 347540 59263 52940453
Obstructive airways disorder 1318.37 9.85 1015 348335 16414 52983302
Poor quality device used 1216.74 9.85 504 348846 2118 52997598
Cough 1137.26 9.85 3980 345370 252913 52746803
Sleep disorder due to a general medical condition 843.18 9.85 555 348795 6902 52992814
Productive cough 830.41 9.85 1400 347950 55329 52944387
Blood count abnormal 763.51 9.85 797 348553 19518 52980198
Forced expiratory volume decreased 736.45 9.85 458 348892 5127 52994589
Chest discomfort 718.33 9.85 1837 347513 97858 52901858
Device delivery system issue 714.37 9.85 229 349121 349 52999367
Completed suicide 649.21 9.85 73 349277 138128 52861588
Rheumatoid arthritis 640.02 9.85 670 348680 313861 52685855
Sputum discoloured 622.00 9.85 608 348742 13731 52985985
Infective pulmonary exacerbation of cystic fibrosis 577.84 9.85 522 348828 10634 52989082
Pneumonia 574.88 9.85 4590 344760 402579 52597137
Synovitis 511.72 9.85 55 349295 107838 52891878
Treatment failure 482.14 9.85 123 349227 128280 52871436
Systemic lupus erythematosus 476.98 9.85 117 349233 125297 52874419
Hand deformity 469.55 9.85 20 349330 84829 52914887
Bronchitis 453.84 9.85 1687 347663 110212 52889504
Drug intolerance 452.02 9.85 408 348942 205085 52794631
Glossodynia 404.61 9.85 82 349268 100209 52899507
Drug ineffective 385.60 9.85 3465 345885 813780 52185936
Therapeutic product effect incomplete 368.11 9.85 1379 347971 90405 52909311
Alopecia 366.78 9.85 607 348743 233976 52765740
Arthropathy 358.79 9.85 243 349107 141210 52858506
Contraindicated product administered 348.03 9.85 230 349120 135399 52864317
Off label use 329.43 9.85 1784 347566 470428 52529288
Anti-cyclic citrullinated peptide antibody positive 321.29 9.85 12 349338 57160 52942556
No adverse event 305.02 9.85 745 348605 38520 52961196
Toxicity to various agents 302.46 9.85 614 348736 218984 52780732
Pericarditis 283.08 9.85 42 349308 64364 52935352
Product dose omission issue 279.60 9.85 2179 347171 189441 52810275
Lower respiratory tract infection 277.15 9.85 1256 348094 89725 52909991
Respiratory disorder 271.31 9.85 653 348697 33444 52966272
Neutropenia 243.91 9.85 417 348933 158768 52840948
Nasal congestion 226.45 9.85 816 348534 52471 52947245
Middle insomnia 225.45 9.85 313 349037 10395 52989321
Wound 218.09 9.85 168 349182 91389 52908327
Infusion related reaction 218.08 9.85 432 348918 155525 52844191
Bronchospasm 215.81 9.85 389 348961 16209 52983507
Eosinophil count increased 214.51 9.85 289 349061 9323 52990393
Dyspnoea exertional 214.30 9.85 819 348531 54181 52945535
Abdominal discomfort 213.79 9.85 737 348613 220325 52779391
Thrombocytopenia 211.96 9.85 364 348986 138363 52861353
Drug abuse 211.56 9.85 82 349268 65444 52934272
Maternal exposure during pregnancy 210.92 9.85 439 348911 155200 52844516
Therapeutic product effect decreased 204.79 9.85 316 349034 125339 52874377
Pulmonary function test decreased 200.47 9.85 187 349163 3974 52995742
Upper respiratory tract infection 196.45 9.85 935 348415 68162 52931554
Febrile neutropenia 196.04 9.85 239 349111 104697 52895019
Hepatic enzyme increased 193.80 9.85 330 349020 125865 52873851
Sinusitis 190.17 9.85 1811 347539 166753 52832963
Nasal polyps 190.09 9.85 157 349193 2819 52996897
Intentional overdose 184.78 9.85 105 349245 67100 52932616
Ear pain 179.49 9.85 513 348837 29160 52970556
Sleep apnoea syndrome 174.57 9.85 467 348883 25535 52974181
Breath sounds abnormal 169.87 9.85 242 349108 8235 52991481
Device malfunction 167.62 9.85 341 349009 15567 52984149
Duodenal ulcer perforation 166.57 9.85 18 349332 35165 52964551
Helicobacter infection 165.97 9.85 28 349322 39041 52960675
Pancytopenia 159.60 9.85 217 349133 90711 52909005
Loss of personal independence in daily activities 158.99 9.85 888 348462 68927 52930789
Blood immunoglobulin E increased 158.92 9.85 126 349224 2129 52997587
Anaemia 153.88 9.85 1120 348230 275598 52724118
Drug interaction 153.85 9.85 826 348524 218503 52781213
Cystic fibrosis 150.84 9.85 156 349194 3775 52995941
Influenza 144.67 9.85 1095 348255 94284 52905432
Bronchiectasis 141.14 9.85 252 349098 10420 52989296
Malignant neoplasm progression 136.72 9.85 160 349190 71381 52928335
Urticaria 134.86 9.85 1422 347928 134463 52865253
Rales 133.40 9.85 248 349102 10584 52989132
Food allergy 132.51 9.85 212 349138 8006 52991710
Oropharyngeal pain 132.36 9.85 949 348401 80319 52919397
Heart rate increased 131.06 9.85 956 348394 81359 52918357
Leukopenia 130.25 9.85 174 349176 73289 52926427
Oxygen saturation decreased 129.06 9.85 903 348447 75822 52923894
Emphysema 128.95 9.85 233 349117 9726 52989990
Gastrooesophageal reflux disease 127.59 9.85 953 348397 81710 52918006
Chest pain 125.65 9.85 1844 347506 188341 52811375
Dysphonia 125.40 9.85 576 348774 41362 52958354
Discomfort 125.34 9.85 274 349076 95198 52904518
Reversible airways obstruction 124.12 9.85 83 349267 1061 52998655
Joint swelling 124.05 9.85 963 348387 233675 52766041
Respiratory tract congestion 122.85 9.85 287 349063 14412 52985304
Body temperature increased 120.08 9.85 479 348871 32320 52967396
Sedation complication 119.88 9.85 188 349162 6978 52992738
Secretion discharge 118.85 9.85 232 349118 10274 52989442
Swelling 118.33 9.85 749 348601 190356 52809360
Arthralgia 115.34 9.85 2107 347243 437676 52562040
Peak expiratory flow rate decreased 114.01 9.85 66 349284 641 52999075
White blood cell count decreased 110.32 9.85 430 348920 124045 52875671
Sensitivity to weather change 108.56 9.85 165 349185 5957 52993759
Forced vital capacity decreased 107.20 9.85 74 349276 1000 52998716
Impaired healing 106.93 9.85 159 349191 64046 52935670
Respiratory tract infection 106.60 9.85 466 348884 32758 52966958
Hepatocellular injury 106.34 9.85 32 349318 29954 52969762
Eosinophilic bronchitis 105.34 9.85 56 349294 453 52999263
Asthmatic crisis 104.92 9.85 91 349259 1752 52997964
Platelet count decreased 103.95 9.85 361 348989 107738 52891978
Upper-airway cough syndrome 103.46 9.85 203 349147 9024 52990692
Full blood count abnormal 103.44 9.85 127 349223 3728 52995988
Rhinitis allergic 103.38 9.85 184 349166 7589 52992127
General physical health deterioration 101.51 9.85 556 348794 146386 52853330
Malaise 100.81 9.85 3059 346291 354558 52645158
Lung hyperinflation 100.79 9.85 76 349274 1188 52998528
Musculoskeletal stiffness 100.70 9.85 440 348910 122928 52876788
Eosinophilic granulomatosis with polyangiitis 100.53 9.85 96 349254 2103 52997613
Haemoptysis 98.27 9.85 404 348946 27635 52972081
Respiration abnormal 98.24 9.85 149 349201 5369 52994347
Eosinophil count abnormal 98.22 9.85 56 349294 527 52999189
Respiratory distress 97.01 9.85 459 348891 33368 52966348
Hepatic function abnormal 96.71 9.85 61 349289 36838 52962878
Product container issue 95.85 9.85 88 349262 1831 52997885
Anxiety 94.52 9.85 1811 347539 194893 52804823
Respiratory rate increased 94.05 9.85 233 349117 12150 52987566
Circumstance or information capable of leading to medication error 93.27 9.85 119 349231 3635 52996081
Rheumatoid factor positive 92.59 9.85 80 349270 41118 52958598
Sleep disorder due to general medical condition, insomnia type 91.94 9.85 23 349327 24326 52975390
Muscle spasticity 90.56 9.85 290 349060 17548 52982168
Temperature regulation disorder 90.10 9.85 124 349226 4083 52995633
Sopor 89.79 9.85 15 349335 21069 52978647
Folliculitis 89.38 9.85 48 349302 31661 52968055
Seasonal allergy 89.28 9.85 261 349089 15024 52984692
Status asthmaticus 88.37 9.85 63 349287 899 52998817
Stomatitis 88.31 9.85 337 349013 97821 52901895
Acute respiratory failure 88.08 9.85 422 348928 30836 52968880
Bronchospasm paradoxical 85.80 9.85 31 349319 81 52999635
Coma 83.84 9.85 174 349176 61609 52938107
Product delivery mechanism issue 81.28 9.85 43 349307 344 52999372
Hypoventilation 81.09 9.85 120 349230 4229 52995487
Lip swelling 80.86 9.85 373 348977 26828 52972888
Creatinine renal clearance decreased 80.46 9.85 200 349150 10451 52989265
Hepatotoxicity 80.36 9.85 41 349309 27839 52971877
Headache 79.97 9.85 4287 345063 532534 52467182
Night sweats 79.85 9.85 445 348905 34502 52965214
Anaphylactic reaction 79.80 9.85 654 348696 57672 52942044
Bronchial secretion retention 79.35 9.85 74 349276 1572 52998144
Cardio-respiratory arrest 79.29 9.85 166 349184 58592 52941124
Bronchopulmonary aspergillosis allergic 78.94 9.85 66 349284 1206 52998510
Muscle injury 78.29 9.85 49 349301 29717 52969999
Mucosal inflammation 78.23 9.85 99 349251 42685 52957031
Device information output issue 77.58 9.85 24 349326 30 52999686
Sputum increased 77.08 9.85 84 349266 2162 52997554
Blood test abnormal 76.76 9.85 207 349143 11370 52988346
Renal impairment 76.27 9.85 284 349066 83034 52916682
Bone marrow failure 74.60 9.85 53 349297 30062 52969654
Respiratory symptom 73.89 9.85 89 349261 2560 52997156
Suicide attempt 73.02 9.85 171 349179 57997 52941719
Bronchial obstruction 72.35 9.85 69 349281 1509 52998207
C-reactive protein increased 72.00 9.85 217 349133 67669 52932047
Hospitalisation 71.73 9.85 746 348604 70266 52929450
Sinus disorder 71.16 9.85 276 349074 18378 52981338
Cytomegalovirus infection 70.85 9.85 20 349330 19519 52980197
Alanine aminotransferase increased 70.59 9.85 351 348999 94744 52904972
Bronchial wall thickening 70.06 9.85 57 349293 1001 52998715
Knee arthroplasty 69.75 9.85 70 349280 33499 52966217
Rheumatic fever 69.60 9.85 3 349347 12601 52987115
Dust allergy 69.36 9.85 47 349303 615 52999101
Death 68.53 9.85 1798 347552 355434 52644282
Pulmonary mass 68.35 9.85 286 349064 19718 52979998
Hypoxia 68.10 9.85 609 348741 55071 52944645
Swollen tongue 67.87 9.85 391 348959 30689 52969027
Hip arthroplasty 67.75 9.85 50 349300 27812 52971904
Drug hypersensitivity 67.42 9.85 1277 348073 263965 52735751
Throat tightness 67.04 9.85 306 349044 21910 52977806
Vital capacity decreased 66.75 9.85 55 349295 984 52998732
Nasopharyngitis 66.16 9.85 1688 347662 190607 52809109
Product cleaning inadequate 65.39 9.85 18 349332 9 52999707
Drug reaction with eosinophilia and systemic symptoms 65.22 9.85 71 349279 32729 52966987
Product use issue 65.05 9.85 592 348758 138992 52860724
Femur fracture 64.96 9.85 99 349251 39486 52960230
Chronic sinusitis 64.49 9.85 129 349221 5816 52993900
Humidity intolerance 64.03 9.85 37 349313 358 52999358
Restrictive pulmonary disease 63.69 9.85 64 349286 1495 52998221
Total lung capacity increased 63.45 9.85 50 349300 837 52998879
Sputum purulent 62.70 9.85 53 349297 984 52998732
Aspartate aminotransferase increased 61.88 9.85 311 349039 83718 52915998
Allergy to animal 61.26 9.85 49 349301 839 52998877
Choking 60.64 9.85 165 349185 9111 52990605
Increased upper airway secretion 60.47 9.85 92 349258 3324 52996392
Metastases to liver 59.91 9.85 33 349317 21463 52978253
Acute kidney injury 59.45 9.85 1239 348111 252629 52747087
Infective exacerbation of chronic obstructive airways disease 59.16 9.85 57 349293 1263 52998453
Pulmonary function test abnormal 59.11 9.85 60 349290 1419 52998297
Multiple organ dysfunction syndrome 59.02 9.85 178 349172 55499 52944217
Toxic epidermal necrolysis 58.92 9.85 41 349309 23509 52976207
Rhinitis 58.74 9.85 160 349190 8841 52990875
Pharyngeal swelling 58.23 9.85 108 349242 4600 52995116
Throat clearing 58.15 9.85 53 349297 1092 52998624
Rhinorrhoea 58.01 9.85 571 348779 53007 52946709
Neutrophil count decreased 57.96 9.85 149 349201 48949 52950767
Blood pressure systolic increased 57.94 9.85 412 348938 34765 52964951
Polycystic ovaries 57.89 9.85 73 349277 2203 52997513
Posterior reversible encephalopathy syndrome 57.75 9.85 17 349333 16143 52983573
Palpitations 57.48 9.85 966 348384 101382 52898334
Device ineffective 56.93 9.85 27 349323 166 52999550
Cholestasis 55.00 9.85 64 349286 28631 52971085
Viral infection 54.80 9.85 381 348969 31914 52967802
Circumstance or information capable of leading to device use error 54.47 9.85 24 349326 121 52999595
Illness 54.40 9.85 290 349060 22106 52977610
Overdose 54.15 9.85 448 348902 107288 52892428
Drug-induced liver injury 54.11 9.85 67 349283 29166 52970550
Disease progression 53.91 9.85 418 348932 101502 52898214
Total lung capacity decreased 53.85 9.85 56 349294 1364 52998352
Liver injury 53.31 9.85 40 349310 22063 52977653
Neurotoxicity 53.31 9.85 17 349333 15332 52984384
Myelosuppression 52.73 9.85 10 349340 12818 52986898
Rash 52.66 9.85 2387 346963 443804 52555912
Decreased appetite 52.15 9.85 1043 348307 213931 52785785
Lower respiratory tract congestion 51.63 9.85 66 349284 2020 52997696
Altered state of consciousness 51.36 9.85 52 349298 24784 52974932
Perfume sensitivity 51.17 9.85 39 349311 620 52999096
Coeliac disease 50.86 9.85 149 349201 8586 52991130
Smoke sensitivity 50.24 9.85 29 349321 280 52999436
Eczema 50.07 9.85 300 349050 23882 52975834
Lung neoplasm malignant 50.04 9.85 232 349118 16720 52982996
Rhonchi 49.85 9.85 71 349279 2415 52997301
Orthostatic hypotension 48.73 9.85 348 349002 29405 52970311
Lung disorder 47.88 9.85 502 348848 47377 52952339
Blood calcium decreased 47.87 9.85 256 349094 19538 52980178
Cholecystitis chronic 47.17 9.85 164 349186 10354 52989362
Agranulocytosis 46.57 9.85 52 349298 23697 52976019
Respiratory tract inflammation 46.37 9.85 35 349315 548 52999168
Palmar-plantar erythrodysaesthesia syndrome 46.11 9.85 44 349306 21562 52978154
Sneezing 45.70 9.85 204 349146 14468 52985248
Osteonecrosis of jaw 45.57 9.85 106 349244 36040 52963676
Neoplasm progression 45.19 9.85 79 349271 29840 52969876
Respiratory failure 45.04 9.85 916 348434 99596 52900120
Throat irritation 44.82 9.85 358 348992 31323 52968393
Anuria 44.61 9.85 13 349337 12427 52987289
Drug resistance 44.56 9.85 39 349311 19923 52979793
Inhalation therapy 44.42 9.85 17 349333 55 52999661
Pneumocystis jirovecii pneumonia 44.42 9.85 26 349324 16352 52983364
Cerebral infarction 44.23 9.85 57 349293 24387 52975329
Nasal mucosal disorder 44.11 9.85 30 349320 395 52999321
Blister 44.01 9.85 318 349032 78435 52921281
Nausea 43.89 9.85 4311 345039 751780 52247936
Prolonged expiration 43.87 9.85 35 349315 597 52999119
Asthma-chronic obstructive pulmonary disease overlap syndrome 43.67 9.85 35 349315 601 52999115
Fluid retention 43.44 9.85 546 348804 53855 52945861
Serotonin syndrome 43.37 9.85 66 349284 26340 52973376
Product taste abnormal 43.34 9.85 61 349289 2052 52997664
Back pain 42.94 9.85 1910 347440 232337 52767379
Red blood cell sedimentation rate increased 42.45 9.85 74 349276 27983 52971733
Psoriatic arthropathy 42.32 9.85 167 349183 48023 52951693
Disseminated intravascular coagulation 42.26 9.85 40 349310 19679 52980037
Sensitisation 42.20 9.85 48 349302 1297 52998419
Irritable bowel syndrome 41.72 9.85 146 349204 43486 52956230
Product complaint 41.68 9.85 175 349175 12082 52987634
Bronchial hyperreactivity 41.11 9.85 50 349300 1453 52998263
Poisoning 40.47 9.85 20 349330 13830 52985886
Emotional distress 40.30 9.85 355 348995 31962 52967754
Mite allergy 40.09 9.85 31 349319 504 52999212
Poisoning deliberate 39.89 9.85 5 349345 8708 52991008
Conjunctivitis allergic 39.75 9.85 37 349313 784 52998932
Somnolence 39.41 9.85 818 348532 166916 52832800
Nasal discharge discolouration 39.34 9.85 51 349299 1583 52998133
Increased bronchial secretion 39.32 9.85 53 349297 1710 52998006
Sinus congestion 39.32 9.85 194 349156 14344 52985372
Injection site reaction 39.03 9.85 187 349163 50979 52948737
Diarrhoea 38.46 9.85 3551 345799 621995 52377721
Injection site pain 38.44 9.85 517 348833 112874 52886842
Metastases to bone 38.25 9.85 42 349308 19286 52980430
Lung diffusion test decreased 38.09 9.85 34 349316 681 52999035
Frustration tolerance decreased 37.83 9.85 106 349244 5955 52993761
Cerebral haemorrhage 37.78 9.85 88 349262 29908 52969808
Transplant rejection 37.54 9.85 10 349340 10141 52989575
Aphonia 37.53 9.85 137 349213 8861 52990855
Polyp 37.47 9.85 104 349246 5810 52993906
Septic shock 37.38 9.85 246 349104 61983 52937733
Blood lactate dehydrogenase increased 37.17 9.85 53 349297 21728 52977988
Neuropathy peripheral 36.99 9.85 465 348885 102722 52896994
Shock 36.89 9.85 59 349291 23080 52976636
Drug tolerance decreased 36.86 9.85 3 349347 7355 52992361
Myelodysplastic syndrome 36.65 9.85 33 349317 16627 52983089
Intentional product use issue 36.62 9.85 301 349049 72193 52927523
Febrile bone marrow aplasia 35.82 9.85 3 349347 7186 52992530
Paranasal sinus discomfort 35.81 9.85 68 349282 2949 52996767
Eosinophilia 35.79 9.85 251 349099 21084 52978632
Gamma-glutamyltransferase increased 35.76 9.85 107 349243 33448 52966268
Haemophagocytic lymphohistiocytosis 35.74 9.85 8 349342 9129 52990587
Interstitial lung disease 35.59 9.85 231 349119 58391 52941325
Drug eruption 35.46 9.85 69 349281 25025 52974691
Lung opacity 34.98 9.85 53 349297 1908 52997808
Cardiac failure 34.98 9.85 376 348974 85468 52914248
Rheumatoid nodule 34.86 9.85 17 349333 11847 52987869
Gastrointestinal disorder 34.78 9.85 399 348951 89605 52910111
Multiple allergies 34.30 9.85 128 349222 8367 52991349
Renal failure 34.28 9.85 557 348793 117895 52881821
Chronic respiratory failure 34.13 9.85 50 349300 1746 52997970
Incorrect dose administered 34.05 9.85 496 348854 50549 52949167
Lymphopenia 34.00 9.85 36 349314 16807 52982909
Paraesthesia oral 33.95 9.85 172 349178 12853 52986863
Cardiotoxicity 33.88 9.85 4 349346 7295 52992421
Inflammation 33.75 9.85 227 349123 56909 52942807
Intentional self-injury 33.63 9.85 72 349278 25212 52974504
Bronchial disorder 33.62 9.85 41 349309 1195 52998521
Nasal turbinate hypertrophy 33.30 9.85 31 349319 657 52999059
Burning sensation 33.00 9.85 469 348881 47544 52952172
Nasal obstruction 32.91 9.85 38 349312 1044 52998672
Hyper IgE syndrome 32.88 9.85 25 349325 396 52999320
Psoriasis 32.52 9.85 389 348961 86700 52913016
Immunodeficiency 32.48 9.85 188 349162 14779 52984937
Status epilepticus 32.31 9.85 31 349319 15153 52984563
Breath alcohol test positive 32.28 9.85 8 349342 0 52999716
Idiopathic intracranial hypertension 32.23 9.85 61 349289 2639 52997077
Ascites 32.22 9.85 142 349208 39593 52960123
Therapy non-responder 32.18 9.85 189 349161 48931 52950785
Epilepsy 32.13 9.85 76 349274 25691 52974025
Progressive multifocal leukoencephalopathy 31.85 9.85 20 349330 12109 52987607
Rash maculo-papular 31.60 9.85 95 349255 29654 52970062
Pulmonary embolism 31.32 9.85 976 348374 113466 52886250
Acute myeloid leukaemia 31.14 9.85 39 349311 16893 52982823
Confusional state 31.00 9.85 1002 348348 193219 52806497
Blood creatinine increased 30.95 9.85 369 348981 82293 52917423
Hepatic failure 30.86 9.85 125 349225 35681 52964035
Exposure during pregnancy 30.78 9.85 604 348746 124256 52875460
Stress cardiomyopathy 30.50 9.85 124 349226 8438 52991278
Device expulsion 30.39 9.85 97 349253 29716 52970000
Sinus operation 30.30 9.85 46 349304 1659 52998057
Fatigue 30.28 9.85 4259 345091 726247 52273469
Panniculitis 30.25 9.85 7 349343 7807 52991909
Pulmonary congestion 30.05 9.85 195 349155 15961 52983755
Sinus pain 30.03 9.85 54 349296 2245 52997471
Cystic fibrosis respiratory infection suppression 29.71 9.85 25 349325 461 52999255
Thrombotic microangiopathy 29.61 9.85 12 349338 9325 52990391
Exercise tolerance decreased 29.57 9.85 89 349261 5206 52994510
Peritonitis 29.48 9.85 61 349289 21626 52978090
Forced expiratory volume abnormal 29.33 9.85 15 349335 111 52999605
Extrapyramidal disorder 29.20 9.85 23 349327 12379 52987337
Foot deformity 28.98 9.85 48 349302 18520 52981196
Herpes zoster 28.65 9.85 328 349022 73691 52926025
Eye pruritus 28.46 9.85 168 349182 13301 52986415
Acute hepatic failure 28.22 9.85 41 349309 16679 52983037
Sinusitis fungal 28.14 9.85 40 349310 1358 52998358
Blood parathyroid hormone decreased 28.03 9.85 4 349346 6314 52993402
Swelling face 27.96 9.85 528 348822 56640 52943076
C-reactive protein abnormal 27.92 9.85 82 349268 25788 52973928
Insomnia 27.88 9.85 1495 347855 185577 52814139
Embolism venous 27.78 9.85 61 349289 2938 52996778
Aspirin-exacerbated respiratory disease 27.75 9.85 32 349318 878 52998838
Ventricular failure 27.61 9.85 23 349327 418 52999298
Hereditary angioedema 27.61 9.85 97 349253 6156 52993560
Sputum retention 27.17 9.85 26 349324 571 52999145
Condition aggravated 27.10 9.85 1631 347719 295503 52704213
Spirometry abnormal 26.99 9.85 18 349332 229 52999487
Enthesopathy 26.92 9.85 5 349345 6506 52993210
Vocal cord dysfunction 26.88 9.85 20 349330 306 52999410
Fracture 26.83 9.85 48 349302 17971 52981745
Hiatus hernia 26.82 9.85 220 349130 19400 52980316
Wrong technique in device usage process 26.71 9.85 55 349295 2532 52997184
Device defective 26.67 9.85 38 349312 1293 52998423
Toxic skin eruption 26.61 9.85 28 349322 13111 52986605
Graft versus host disease 26.36 9.85 7 349343 7115 52992601
Hypertensive crisis 26.06 9.85 34 349316 14472 52985244
Pyrexia 25.97 9.85 2280 347070 400913 52598803
Broncholithiasis 25.96 9.85 16 349334 176 52999540
Exposure to allergen 25.91 9.85 17 349333 210 52999506
Bradycardia 25.91 9.85 319 349031 70737 52928979
Forced expiratory flow decreased 25.87 9.85 11 349339 50 52999666
Pruritus 25.84 9.85 2247 347103 291585 52708131
Injury 25.70 9.85 473 348877 50498 52949218
Muscle rigidity 25.66 9.85 20 349330 10821 52988895
Rhinovirus infection 25.51 9.85 69 349281 3796 52995920
Seizure 25.50 9.85 649 348701 128860 52870856
Sedation 25.49 9.85 302 349048 29373 52970343
Plasma cell myeloma 25.46 9.85 196 349154 47678 52952038
Respiratory gas exchange disorder 25.39 9.85 23 349327 470 52999246
Product use in unapproved indication 25.36 9.85 551 348799 111738 52887978
Osteonecrosis 25.35 9.85 89 349261 26486 52973230
Proteinuria 25.26 9.85 50 349300 18018 52981698
Infusion site swelling 25.00 9.85 101 349249 6853 52992863
Hypercapnia 24.86 9.85 81 349269 4946 52994770
Respiratory tract infection viral 24.77 9.85 45 349305 1886 52997830
Foreign body in reproductive tract 24.55 9.85 22 349328 443 52999273
Respiratory tract irritation 24.27 9.85 22 349328 450 52999266
Bronchial neoplasm 24.27 9.85 21 349329 403 52999313
Feeling abnormal 24.27 9.85 1101 348249 134200 52865516
Breast cancer 24.00 9.85 207 349143 49151 52950565
Bronchitis bacterial 23.99 9.85 27 349323 721 52998995
Disorientation 23.93 9.85 155 349195 39204 52960512
Dermatitis atopic 23.87 9.85 67 349283 3767 52995949
Polyneuropathy 23.79 9.85 31 349319 13202 52986514
Distal intestinal obstruction syndrome 23.72 9.85 22 349328 464 52999252
Blood cholesterol increased 23.69 9.85 227 349123 52762 52946954
Breast cancer metastatic 23.58 9.85 40 349310 15288 52984428
Ulcer 23.25 9.85 64 349286 20555 52979161
Rectal prolapse 23.24 9.85 43 349307 1828 52997888
Colitis 23.10 9.85 168 349182 41384 52958332
Tuberculosis 23.10 9.85 23 349327 11048 52988668
Lymph node calcification 23.08 9.85 17 349333 256 52999460
Transaminases increased 23.05 9.85 110 349240 30022 52969694
Salpingo-oophorectomy unilateral 23.02 9.85 25 349325 641 52999075
Abortion spontaneous 22.93 9.85 195 349155 46440 52953276
Gait disturbance 22.89 9.85 830 348520 158012 52841704
Rhabdomyolysis 22.81 9.85 181 349169 43742 52955974
Nasal oedema 22.73 9.85 30 349320 948 52998768
Generalised tonic-clonic seizure 22.58 9.85 104 349246 28654 52971062
Drug level increased 22.57 9.85 64 349286 20357 52979359
Unintentional medical device removal 22.56 9.85 4 349346 5382 52994334
Uveitis 22.56 9.85 18 349332 9626 52990090
Hypoalbuminaemia 22.49 9.85 23 349327 10913 52988803
Bronchial haemorrhage 22.45 9.85 22 349328 498 52999218
Vocal cord disorder 22.39 9.85 36 349314 1365 52998351
Rubber sensitivity 22.37 9.85 43 349307 1882 52997834
Intentional device misuse 22.26 9.85 28 349322 843 52998873
Rash erythematous 22.17 9.85 358 348992 37265 52962451
Inappropriate antidiuretic hormone secretion 22.11 9.85 40 349310 14911 52984805
Infusion site erythema 21.95 9.85 115 349235 8707 52991009
Tubulointerstitial nephritis 21.94 9.85 47 349303 16457 52983259
Asthma exercise induced 21.94 9.85 18 349332 320 52999396
Painful respiration 21.91 9.85 52 349298 2638 52997078
Diffuse large B-cell lymphoma 21.86 9.85 8 349342 6617 52993099
Nasal inflammation 21.81 9.85 21 349329 465 52999251
Ischaemic stroke 21.70 9.85 54 349296 17939 52981777
Pharyngeal oedema 21.70 9.85 167 349183 14446 52985270
Gallbladder injury 21.68 9.85 35 349315 1332 52998384
Pulmonary pain 21.66 9.85 47 349303 2245 52997471
Dehydration 21.64 9.85 892 348458 167518 52832198
Choking sensation 21.62 9.85 61 349289 3440 52996276
Hypersensitivity 21.40 9.85 1629 347721 209036 52790680
Hepatitis cholestatic 21.12 9.85 10 349340 7089 52992627
Cardiac arrest 21.04 9.85 460 348890 93207 52906509
Pneumonia aspiration 20.90 9.85 135 349215 34166 52965550
Encephalopathy 20.86 9.85 148 349202 36660 52963056
Haemoglobin decreased 20.80 9.85 713 348637 136594 52863122
Injection site erythema 20.80 9.85 368 348982 76881 52922835
Crepitations 20.70 9.85 94 349256 6715 52993001
Pregnancy 20.58 9.85 121 349229 31320 52968396
Bronchomalacia 20.58 9.85 15 349335 222 52999494
Prescribed underdose 20.51 9.85 45 349305 15622 52984094
Respiratory arrest 20.44 9.85 132 349218 33408 52966308
Incorrect dose administered by device 20.25 9.85 60 349290 3479 52996237
Blood pressure increased 20.20 9.85 1119 348231 139360 52860356
Neutrophilia 20.19 9.85 60 349290 3485 52996231
Premature delivery 20.14 9.85 95 349255 26009 52973707
Blood bilirubin increased 20.09 9.85 144 349206 35586 52964130
Oxygen consumption increased 20.07 9.85 62 349288 3679 52996037
Akathisia 20.05 9.85 16 349334 8555 52991161
Osteomyelitis 20.02 9.85 86 349264 24149 52975567
Metastases to central nervous system 19.93 9.85 30 349320 12027 52987689
Peripheral sensory neuropathy 19.88 9.85 11 349339 7137 52992579
Device deposit issue 19.73 9.85 7 349343 17 52999699
Rebound nasal congestion 19.62 9.85 8 349342 32 52999684
Dermatitis allergic 19.56 9.85 154 349196 13414 52986302
Haemorrhage intracranial 19.49 9.85 36 349314 13316 52986400
Brain oedema 19.40 9.85 37 349313 13521 52986195
Sputum culture positive 19.35 9.85 35 349315 1462 52998254
Bradyphrenia 19.34 9.85 10 349340 6740 52992976
Type 2 diabetes mellitus 19.28 9.85 303 349047 31367 52968349
Psychotic disorder 19.26 9.85 88 349262 24297 52975419
Shock haemorrhagic 19.25 9.85 19 349331 9164 52990552
Haemolytic anaemia 19.24 9.85 24 349326 10415 52989301
Tobacco abuse 19.11 9.85 23 349327 661 52999055
Musculoskeletal pain 19.07 9.85 362 348988 74838 52924878
Ejection fraction 18.96 9.85 28 349322 985 52998731
Cervix neoplasm 18.77 9.85 14 349336 215 52999501
Stress urinary incontinence 18.65 9.85 44 349306 2223 52997493
Ejection fraction decreased 18.58 9.85 67 349283 19781 52979935
Expired product administered 18.52 9.85 82 349268 5794 52993922
Bursitis 18.49 9.85 227 349123 22265 52977451
Pathogen resistance 18.38 9.85 10 349340 6550 52993166
Tracheomalacia 18.38 9.85 12 349338 147 52999569
Balance disorder 18.37 9.85 618 348732 72589 52927127
Accidental exposure to product 18.36 9.85 86 349264 23588 52976128
Cardiac failure congestive 18.22 9.85 762 348588 91995 52907721
Nasal pruritus 18.12 9.85 17 349333 364 52999352
Angioedema 18.03 9.85 381 348969 41695 52958021
Enterocolitis 18.01 9.85 12 349338 7040 52992676
Cytokine release syndrome 18.00 9.85 16 349334 8113 52991603
Leukoencephalopathy 18.00 9.85 3 349347 4221 52995495
Hypercalcaemia 17.98 9.85 90 349260 24258 52975458
Bronchitis chronic 17.93 9.85 65 349285 4189 52995527
Skin necrosis 17.77 9.85 26 349324 10546 52989170
Aplastic anaemia 17.69 9.85 17 349333 8304 52991412
Lip discolouration 17.59 9.85 20 349330 540 52999176
Metastases to lung 17.59 9.85 31 349319 11673 52988043
Airway remodelling 17.55 9.85 9 349341 67 52999649
Product prescribing issue 17.38 9.85 30 349320 1207 52998509
Peritonitis bacterial 17.37 9.85 22 349328 9483 52990233
Magnetic resonance imaging thoracic abnormal 17.36 9.85 7 349343 27 52999689
Immune reconstitution inflammatory syndrome 17.31 9.85 10 349340 6336 52993380
PCO2 increased 17.27 9.85 30 349320 1213 52998503
Oxygen therapy 17.26 9.85 39 349311 1915 52997801
Carbon dioxide increased 17.22 9.85 30 349320 1216 52998500
Electrocardiogram QRS complex prolonged 17.22 9.85 8 349342 5734 52993982
Impaired work ability 17.22 9.85 42 349308 14048 52985668
Tremor 17.19 9.85 997 348353 124739 52874977
Nicotine dependence 17.14 9.85 21 349329 615 52999101
Limb injury 17.14 9.85 215 349135 21195 52978521
Jaundice 17.12 9.85 122 349228 30191 52969525
Respiratory acidosis 17.10 9.85 85 349265 6303 52993413
Oropharyngeal discomfort 17.02 9.85 62 349288 4006 52995710
Purpura 16.99 9.85 28 349322 10825 52988891
Infection 16.98 9.85 938 348412 171267 52828449
Hyperkalaemia 16.74 9.85 252 349098 54004 52945712
Foreign body aspiration 16.67 9.85 12 349338 174 52999542
Occupational asthma 16.62 9.85 11 349339 138 52999578
Erysipelas 16.62 9.85 14 349336 7287 52992429
Cytomegalovirus viraemia 16.51 9.85 6 349344 4985 52994731
Sinus tachycardia 16.49 9.85 231 349119 23341 52976375
Aphthous ulcer 16.49 9.85 29 349321 10929 52988787
Use of accessory respiratory muscles 16.44 9.85 12 349338 178 52999538
Mouth swelling 16.42 9.85 64 349286 4271 52995445
Mixed liver injury 16.31 9.85 3 349347 3930 52995786
Sinus headache 16.29 9.85 69 349281 4782 52994934
Neuroleptic malignant syndrome 16.22 9.85 34 349316 11999 52987717
Decreased bronchial secretion 16.22 9.85 9 349341 80 52999636
Duodenal ulcer repair 16.13 9.85 8 349342 55 52999661
Depression 16.09 9.85 1400 347950 181652 52818064
Enteritis 16.08 9.85 15 349335 7431 52992285
Tongue pruritus 16.07 9.85 18 349332 478 52999238
Live birth 16.06 9.85 48 349302 15011 52984705
Metastases to lymph nodes 16.05 9.85 15 349335 7425 52992291
FEV1/FVC ratio decreased 16.03 9.85 9 349341 82 52999634
Biliary dyskinesia 16.02 9.85 47 349303 2710 52997006
Separation anxiety disorder 15.93 9.85 7 349343 35 52999681
Nervousness 15.90 9.85 282 349068 29896 52969820
Dyspnoea at rest 15.88 9.85 59 349291 3848 52995868
Migraine 15.88 9.85 661 348689 79756 52919960
Sepsis 15.87 9.85 790 348560 145639 52854077
Aplasia 15.75 9.85 4 349346 4188 52995528
Blood insulin abnormal 15.62 9.85 7 349343 37 52999679
Breast cancer recurrent 15.60 9.85 4 349346 4161 52995555
Body temperature decreased 15.53 9.85 172 349178 16455 52983261
Bacterial disease carrier 15.49 9.85 23 349327 813 52998903
Pharyngitis streptococcal 15.46 9.85 107 349243 8948 52990768
Venous pressure jugular increased 15.45 9.85 20 349330 620 52999096
Blood electrolytes abnormal 15.44 9.85 26 349324 1025 52998691
Pickwickian syndrome 15.33 9.85 15 349335 339 52999377
Anosmia 15.30 9.85 63 349287 4312 52995404
Sarcoidosis 15.21 9.85 74 349276 5440 52994276
Lung operation 15.12 9.85 12 349338 203 52999513
Haematoma 15.12 9.85 145 349205 33699 52966017
Animal scratch 15.10 9.85 24 349326 901 52998815
Drug ineffective for unapproved indication 15.07 9.85 77 349273 20643 52979073
Therapy partial responder 15.06 9.85 11 349339 6152 52993564
Multiple sclerosis relapse 15.01 9.85 205 349145 44648 52955068
Therapeutic response decreased 15.00 9.85 220 349130 47349 52952367
Administration site erythema 14.95 9.85 19 349331 578 52999138
Pneumonia pseudomonal 14.93 9.85 40 349310 2188 52997528
Postural orthostatic tachycardia syndrome 14.93 9.85 25 349325 981 52998735
Infusion site urticaria 14.92 9.85 23 349327 841 52998875
Thyroid atrophy 14.91 9.85 6 349344 23 52999693
Dizziness 14.89 9.85 2711 346639 369548 52630168
Stevens-Johnson syndrome 14.85 9.85 97 349253 24485 52975231
Epstein-Barr virus infection 14.81 9.85 16 349334 7402 52992314
Ear discomfort 14.75 9.85 90 349260 7211 52992505
Nasal septum deviation 14.72 9.85 29 349321 1293 52998423
Rib deformity 14.69 9.85 11 349339 170 52999546
Hepatic cytolysis 14.67 9.85 18 349332 7867 52991849
Pre-existing condition improved 14.66 9.85 97 349253 7992 52991724
Tumour lysis syndrome 14.62 9.85 18 349332 7856 52991860
Nocturnal dyspnoea 14.61 9.85 26 349324 1072 52998644
Psychomotor retardation 14.61 9.85 3 349347 3635 52996081
Cardiac disorder 14.60 9.85 407 348943 46559 52953157
Nightmare 14.53 9.85 179 349171 17572 52982144
Vertigo 14.51 9.85 269 349081 55812 52943904
Ileus paralytic 14.50 9.85 6 349344 4605 52995111
Carbon dioxide abnormal 14.48 9.85 11 349339 174 52999542
Increased viscosity of bronchial secretion 14.47 9.85 14 349336 312 52999404
Nystagmus 14.46 9.85 11 349339 6025 52993691
Cardiac murmur 14.40 9.85 130 349220 11783 52987933
PO2 decreased 14.38 9.85 32 349318 1555 52998161
Functional residual capacity increased 14.37 9.85 9 349341 102 52999614
Colitis ulcerative 14.35 9.85 80 349270 20981 52978735
Pulmonary thrombosis 14.31 9.85 96 349254 7945 52991771
Ovarian hyperstimulation syndrome 14.28 9.85 3 349347 3578 52996138
Hyponatraemia 14.21 9.85 574 348776 108033 52891683
Cognitive disorder 14.19 9.85 389 348961 44389 52955327
Premature baby 14.16 9.85 74 349276 19727 52979989
Pulmonary oedema 14.12 9.85 456 348894 53267 52946449
Thunderclap headache 14.07 9.85 11 349339 182 52999534
Drug dependence 14.06 9.85 208 349142 21264 52978452
Subdural haematoma 14.04 9.85 45 349305 13768 52985948
Central obesity 14.01 9.85 25 349325 1033 52998683
Pulmonary toxicity 14.00 9.85 9 349341 5382 52994334
Sleep terror 14.00 9.85 22 349328 818 52998898
Liver disorder 13.99 9.85 182 349168 39973 52959743
Bacterial tracheitis 13.99 9.85 6 349344 28 52999688
Paranoia 13.99 9.85 125 349225 11299 52988417
Basal cell carcinoma 13.98 9.85 93 349257 23376 52976340
Multiple drug therapy 13.97 9.85 30 349320 1423 52998293
Oral pruritus 13.95 9.85 33 349317 1670 52998046
Fluid overload 13.94 9.85 258 349092 27573 52972143
Mycobacterial disease carrier 13.92 9.85 4 349346 3 52999713
Administration site inflammation 13.92 9.85 4 349346 3 52999713
Skin candida 13.86 9.85 25 349325 1042 52998674
Joint stiffness 13.84 9.85 129 349221 30154 52969562
Pneumococcal infection 13.79 9.85 16 349334 442 52999274
Labelled drug-drug interaction medication error 13.70 9.85 32 349318 10867 52988849
Urinary tract discomfort 13.67 9.85 11 349339 190 52999526
Mucosal discolouration 13.66 9.85 17 349333 506 52999210
Adverse drug reaction 13.64 9.85 258 349092 53367 52946349
Lung diffusion test abnormal 13.62 9.85 8 349342 80 52999636
Cor pulmonale 13.61 9.85 36 349314 1954 52997762
Grip strength decreased 13.60 9.85 36 349314 11713 52988003
Atopy 13.58 9.85 12 349338 237 52999479
Stridor 13.56 9.85 51 349299 3346 52996370
Nephropathy toxic 13.53 9.85 22 349328 8550 52991166
Varicella zoster gastritis 13.50 9.85 6 349344 31 52999685
Laryngeal pain 13.50 9.85 63 349287 4553 52995163
Diastolic hypotension 13.46 9.85 8 349342 82 52999634
Neuromyotonia 13.45 9.85 7 349343 54 52999662
Red cell distribution width abnormal 13.44 9.85 10 349340 153 52999563
Depressed mood 13.43 9.85 327 349023 36637 52963079
Skin toxicity 13.41 9.85 5 349345 4088 52995628
Oliguria 13.40 9.85 25 349325 9213 52990503
Loss of consciousness 13.40 9.85 611 348739 113601 52886115
Hypocalcaemia 13.40 9.85 125 349225 29212 52970504
Caesarean section 13.38 9.85 63 349287 17257 52982459
Arthritis bacterial 13.37 9.85 12 349338 6056 52993660
Heart sounds 13.36 9.85 17 349333 518 52999198
Malignant melanoma 13.36 9.85 32 349318 10770 52988946
Lupus-like syndrome 13.30 9.85 25 349325 9187 52990529
Oesophageal spasm 13.26 9.85 42 349308 2526 52997190
Skin ulcer 13.22 9.85 162 349188 35957 52963759
Neurosensory hypoacusis 13.21 9.85 13 349337 296 52999420
Product adhesion issue 13.19 9.85 10 349340 5487 52994229
Functional residual capacity decreased 13.13 9.85 8 349342 86 52999630
Self-injurious ideation 13.13 9.85 40 349310 2356 52997360
Product expiration date issue 13.11 9.85 5 349345 16 52999700
Nasal mucosal discolouration 13.11 9.85 5 349345 16 52999700
Intentional product misuse 13.07 9.85 236 349114 49156 52950560
Factitious disorder 13.06 9.85 8 349342 87 52999629
Hypothyroidism 12.99 9.85 319 349031 35788 52963928
Peak expiratory flow rate abnormal 12.95 9.85 9 349341 123 52999593
Endometrial ablation 12.93 9.85 22 349328 875 52998841
Essential hypertension 12.91 9.85 64 349286 4741 52994975
Aplasia pure red cell 12.89 9.85 7 349343 4589 52995127
Uterine perforation 12.86 9.85 88 349262 7331 52992385
Hyperammonaemia 12.83 9.85 9 349341 5140 52994576
Klebsiella infection 12.83 9.85 20 349330 7906 52991810
Obstruction 12.83 9.85 37 349313 2113 52997603
Bronchoscopy 12.83 9.85 7 349343 60 52999656
Oesophageal dilatation 12.83 9.85 14 349336 361 52999355
Blood alkaline phosphatase increased 12.80 9.85 192 349158 41170 52958546
Coagulopathy 12.79 9.85 76 349274 19622 52980094
Pemphigoid 12.75 9.85 14 349336 6430 52993286
Hyperbilirubinaemia 12.75 9.85 34 349316 11035 52988681
Pulmonary hypertension 12.73 9.85 327 349023 36943 52962773
Atypical fracture 12.71 9.85 18 349332 609 52999107
Bacterial infection 12.70 9.85 173 349177 17374 52982342
Croup infectious 12.68 9.85 15 349335 423 52999293
Kidney transplant rejection 12.59 9.85 6 349344 4238 52995478
Pharyngeal erythema 12.59 9.85 31 349319 1610 52998106
Nasal turbinate abnormality 12.51 9.85 6 349344 38 52999678
Lung consolidation 12.49 9.85 57 349293 4081 52995635
Oral candidiasis 12.35 9.85 182 349168 18591 52981125
Allergic cough 12.32 9.85 17 349333 561 52999155
Respiratory syncytial virus bronchiolitis 12.23 9.85 13 349337 325 52999391
Blood creatine phosphokinase increased 12.19 9.85 126 349224 28859 52970857
Jaundice cholestatic 12.13 9.85 11 349339 5523 52994193
Wolff-Parkinson-White syndrome 12.11 9.85 8 349342 100 52999616
Device use confusion 12.11 9.85 3 349347 0 52999716
Cystic fibrosis lung 12.08 9.85 9 349341 138 52999578
Crying 12.08 9.85 209 349141 22053 52977663
Cerebrovascular accident 12.07 9.85 564 348786 104610 52895106
Retching 12.06 9.85 142 349208 13791 52985925
Ketoacidosis 12.04 9.85 7 349343 4419 52995297
Overweight 12.04 9.85 49 349301 3336 52996380
Laboratory test abnormal 12.03 9.85 102 349248 24307 52975409
Product label issue 12.01 9.85 20 349330 781 52998935
Bone density decreased 11.99 9.85 35 349315 11029 52988687
Crystal arthropathy 11.95 9.85 12 349338 280 52999436
Poor quality product administered 11.91 9.85 47 349303 3154 52996562
Delirium 11.91 9.85 195 349155 41234 52958482
Parainfluenzae virus infection 11.90 9.85 35 349315 2021 52997695
Nasal flaring 11.89 9.85 5 349345 22 52999694
Angle closure glaucoma 11.84 9.85 38 349312 2302 52997414
Demyelination 11.81 9.85 14 349336 6213 52993503
Tachypnoea 11.76 9.85 157 349193 15697 52984019
Suspected suicide 11.75 9.85 7 349343 4361 52995355
BK virus infection 11.74 9.85 3 349347 3129 52996587
Infective exacerbation of bronchiectasis 11.72 9.85 14 349336 399 52999317
Alanine aminotransferase abnormal 11.72 9.85 5 349345 3768 52995948
Toothache 11.69 9.85 69 349281 17845 52981871
Airway peak pressure increased 11.65 9.85 12 349338 289 52999427
Upper airway obstruction 11.62 9.85 18 349332 661 52999055
Cardiogenic shock 11.59 9.85 67 349283 17415 52982301
Pulmonary tuberculosis 11.56 9.85 9 349341 4872 52994844
Oxygen consumption decreased 11.56 9.85 11 349339 240 52999476
Peripheral vascular disorder 11.53 9.85 74 349276 6034 52993682
Pneumonectomy 11.49 9.85 4 349346 9 52999707
Urethral pain 11.37 9.85 11 349339 245 52999471
Urosepsis 11.37 9.85 63 349287 16547 52983169
Red blood cell count decreased 11.34 9.85 166 349184 35737 52963979
Lactose intolerance 11.31 9.85 42 349308 2739 52996977
Gingivitis 11.28 9.85 22 349328 7973 52991743
Scleritis 11.24 9.85 4 349346 3366 52996350
Panic attack 11.23 9.85 200 349150 21218 52978498
Gingival bleeding 11.22 9.85 42 349308 12266 52987450
Forced expiratory volume increased 11.22 9.85 5 349345 26 52999690
Candida infection 11.20 9.85 230 349120 25043 52974673
Activated partial thromboplastin time 11.20 9.85 4 349346 10 52999706
Pathological fracture 11.19 9.85 24 349326 8400 52991316
Embolism 11.16 9.85 20 349330 7483 52992233
Juvenile idiopathic arthritis 11.15 9.85 8 349342 4516 52995200
Deformity 11.13 9.85 22 349328 7932 52991784
Enterovirus infection 11.12 9.85 19 349331 758 52998958
Sputum abnormal 11.06 9.85 16 349334 552 52999164
Femoral neck fracture 11.04 9.85 24 349326 8359 52991357
Influenza B virus test positive 11.04 9.85 13 349337 365 52999351
Blood iron abnormal 11.01 9.85 4 349346 3323 52996393
Gastroenteritis viral 11.00 9.85 183 349167 19162 52980554
Pneumonia respiratory syncytial viral 11.00 9.85 18 349332 693 52999023
Peptic ulcer perforation 10.97 9.85 9 349341 160 52999556
Respiratory syncytial virus infection 10.96 9.85 66 349284 5262 52994454
Myalgia 10.96 9.85 1016 348334 132475 52867241
Increased viscosity of upper respiratory secretion 10.94 9.85 8 349342 119 52999597
Orthopnoea 10.94 9.85 73 349277 6031 52993685
Spinal pain 10.90 9.85 39 349311 11541 52988175
Injection site bruising 10.89 9.85 177 349173 37469 52962247
Administration site pain 10.88 9.85 18 349332 699 52999017
Bronchiolitis 10.87 9.85 39 349311 2501 52997215
Graft versus host disease in gastrointestinal tract 10.86 9.85 3 349347 2971 52996745
Cerebellar syndrome 10.86 9.85 5 349345 3602 52996114
Tobacco user 10.86 9.85 19 349331 773 52998943
Metastasis 10.86 9.85 9 349341 4722 52994994
Feeling jittery 10.84 9.85 124 349226 11959 52987757
Dyskinesia 10.83 9.85 145 349205 31688 52968028
Eye swelling 10.82 9.85 201 349149 21493 52978223
Adverse reaction 10.81 9.85 27 349323 8960 52990756
Dyspnoea paroxysmal nocturnal 10.80 9.85 20 349330 851 52998865
Foetal exposure during pregnancy 10.79 9.85 161 349189 34554 52965162
Device failure 10.77 9.85 73 349277 6062 52993654
Mydriasis 10.76 9.85 38 349312 11288 52988428
Body temperature abnormal 10.75 9.85 25 349325 1251 52998465
Blood iron decreased 10.75 9.85 125 349225 12103 52987613
Breath sounds 10.72 9.85 8 349342 123 52999593
Incorrect dose administered by product 10.70 9.85 9 349341 166 52999550
Heart block congenital 10.67 9.85 4 349346 12 52999704
Eosinophilia myalgia syndrome 10.67 9.85 4 349346 12 52999704
Chills 10.67 9.85 811 348539 104037 52895679
Musculoskeletal disorder 10.59 9.85 69 349281 17430 52982286
Subarachnoid haemorrhage 10.58 9.85 41 349309 11852 52987864
Thymus disorder 10.55 9.85 10 349340 217 52999499
Diastolic dysfunction 10.54 9.85 70 349280 5774 52993942
Oedema peripheral 10.52 9.85 1275 348075 169512 52830204
Cachexia 10.46 9.85 11 349339 5153 52994563
Hyperventilation 10.41 9.85 73 349277 6131 52993585
Exostosis 10.41 9.85 39 349311 11385 52988331
Trifascicular block 10.40 9.85 8 349342 129 52999587
PCO2 abnormal 10.39 9.85 6 349344 58 52999658
Oropharyngitis fungal 10.39 9.85 6 349344 58 52999658
Tenderness 10.38 9.85 81 349269 19649 52980067
Eosinophilic oesophagitis 10.38 9.85 11 349339 274 52999442
Cerebral haematoma 10.38 9.85 5 349345 3509 52996207
Drug administered in wrong device 10.38 9.85 5 349345 32 52999684
Hypomania 10.35 9.85 10 349340 4872 52994844
Infusion site extravasation 10.26 9.85 73 349277 6159 52993557
Quarantine 10.25 9.85 5 349345 33 52999683
Infusion site nodule 10.21 9.85 23 349327 1127 52998589
Chest X-ray abnormal 10.15 9.85 54 349296 4112 52995604
Product prescribing error 10.15 9.85 99 349251 22932 52976784
Drug dose omission by device 10.12 9.85 38 349312 2491 52997225
Respiratory alkalosis 10.11 9.85 40 349310 2688 52997028
Acute sinusitis 10.10 9.85 52 349298 3910 52995806
Peritoneal dialysis complication 10.09 9.85 3 349347 2830 52996886
Constipation 10.07 9.85 1464 347886 196948 52802768
Pyelonephritis acute 10.06 9.85 9 349341 4550 52995166
Blood pressure ambulatory abnormal 10.05 9.85 3 349347 3 52999713
Allergy to surgical sutures 10.05 9.85 3 349347 3 52999713
Noninfective bronchitis 10.05 9.85 3 349347 3 52999713
Red blood cell agglutination 10.05 9.85 3 349347 3 52999713
Radioallergosorbent test positive 10.05 9.85 3 349347 3 52999713
Retinal haemorrhage 10.03 9.85 11 349339 5054 52994662
Local reaction 10.00 9.85 15 349335 535 52999181
Influenza like illness 10.00 9.85 491 348859 60368 52939348
Acute respiratory distress syndrome 9.98 9.85 101 349249 23231 52976485
Haemolysis 9.95 9.85 17 349333 6479 52993237
Pain 9.95 9.85 3581 345769 584817 52414899
Gastrointestinal perforation 9.89 9.85 5 349345 3414 52996302
Circulatory collapse 9.86 9.85 98 349252 22616 52977100
Tooth disorder 9.85 9.85 112 349238 25200 52974516

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 4473.66 10.73 2906 182816 41159 32286645
Wheezing 2043.68 10.73 1689 184033 35185 32292619
Dyspnoea 1596.65 10.73 5100 180622 356945 31970859
Chronic obstructive pulmonary disease 1386.77 10.73 1546 184176 47207 32280597
Product quality issue 1085.48 10.73 891 184831 18342 32309462
Obstructive airways disorder 836.48 10.73 629 185093 11332 32316472
Cough 808.64 10.73 2166 183556 136651 32191153
Poor quality device used 710.13 10.73 261 185461 874 32326930
Sleep disorder due to a general medical condition 585.30 10.73 314 185408 3020 32324784
Therapeutic product effect incomplete 564.45 10.73 917 184805 40424 32287380
Blood count abnormal 553.84 10.73 512 185210 12414 32315390
Productive cough 541.31 10.73 811 184911 33305 32294499
Device delivery system issue 532.29 10.73 162 185560 234 32327570
Infective pulmonary exacerbation of cystic fibrosis 529.53 10.73 423 185299 8356 32319448
Forced expiratory volume decreased 410.62 10.73 255 185467 3301 32324503
No adverse event 389.27 10.73 525 185197 19528 32308276
Chest discomfort 364.17 10.73 853 184869 49377 32278427
Sputum discoloured 348.36 10.73 313 185409 7303 32320501
Completed suicide 336.35 10.73 61 185661 92456 32235348
Toxicity to various agents 305.71 10.73 340 185382 177701 32150103
Loss of personal independence in daily activities 277.48 10.73 527 185195 26306 32301498
Pneumonia 249.84 10.73 3109 182613 352143 31975661
Pulmonary function test decreased 242.54 10.73 212 185510 4763 32323041
Lower respiratory tract infection 241.31 10.73 523 185199 28720 32299084
Nasal congestion 224.52 10.73 411 185311 19940 32307864
Bronchiectasis 214.46 10.73 231 185491 6761 32321043
Cystic fibrosis 203.20 10.73 141 185581 2225 32325579
Dyspnoea exertional 190.84 10.73 572 185150 38389 32289415
Product dose omission issue 187.80 10.73 1113 184609 101462 32226342
Bronchitis 184.40 10.73 589 185133 40918 32286886
Drug abuse 175.18 10.73 122 185600 80121 32247683
Nasal polyps 170.82 10.73 116 185606 1764 32326040
Bronchospasm 167.33 10.73 256 185466 10699 32317105
Febrile neutropenia 164.74 10.73 268 185454 119298 32208506
Off label use 160.27 10.73 1059 184663 305261 32022543
Drug interaction 155.20 10.73 680 185042 217505 32110299
Neutropenia 152.57 10.73 369 185353 141806 32185998
Breath sounds abnormal 145.23 10.73 176 185546 5869 32321935
Respiratory disorder 144.15 10.73 333 185389 19084 32308720
Hepatic function abnormal 141.99 10.73 40 185682 44800 32283004
Middle insomnia 140.10 10.73 179 185543 6305 32321499
Sinusitis 137.80 10.73 491 185231 36069 32291735
Blood immunoglobulin E increased 134.55 10.73 104 185618 1953 32325851
Influenza 129.71 10.73 564 185158 45450 32282354
Full blood count abnormal 121.98 10.73 115 185607 2858 32324946
Eosinophil count increased 120.28 10.73 190 185532 8165 32319639
Eosinophil count abnormal 116.40 10.73 52 185670 320 32327484
Thrombocytopenia 114.79 10.73 447 185275 147852 32179952
Bronchial obstruction 112.63 10.73 87 185635 1632 32326172
Anaemia 111.81 10.73 783 184939 222841 32104963
Pancytopenia 109.94 10.73 222 185500 91013 32236791
Bronchopulmonary aspergillosis allergic 104.24 10.73 57 185665 571 32327233
Blood test abnormal 96.18 10.73 146 185576 6058 32321746
Asthma-chronic obstructive pulmonary disease overlap syndrome 95.55 10.73 64 185658 950 32326854
Bone marrow failure 92.82 10.73 29 185693 30375 32297429
Mucosal inflammation 91.69 10.73 38 185684 33396 32294408
Diarrhoea 91.30 10.73 1501 184221 363301 31964503
Cytomegalovirus infection 89.89 10.73 18 185704 25446 32302358
Bronchial wall thickening 88.76 10.73 60 185662 905 32326899
Reversible airways obstruction 88.23 10.73 42 185680 305 32327499
Eosinophilic granulomatosis with polyangiitis 88.05 10.73 71 185651 1421 32326383
Renal impairment 86.96 10.73 254 185468 91718 32236086
Leukopenia 86.29 10.73 131 185591 59991 32267813
Emphysema 86.20 10.73 181 185541 9716 32318088
Secretion discharge 85.86 10.73 114 185608 4172 32323632
Respiratory tract congestion 85.78 10.73 134 185588 5702 32322102
Nasopharyngitis 85.09 10.73 640 185082 63147 32264657
Haemoptysis 84.78 10.73 398 185324 33127 32294677
Asthmatic crisis 84.40 10.73 49 185673 556 32327248
Pulmonary function test abnormal 84.26 10.73 80 185642 2006 32325798
Malignant neoplasm progression 82.32 10.73 206 185516 78290 32249514
Device malfunction 81.88 10.73 168 185554 8871 32318933
Sputum increased 81.74 10.73 80 185642 2085 32325719
Hypoxia 81.15 10.73 543 185179 51589 32276215
Platelet count decreased 80.17 10.73 359 185363 114232 32213572
Interstitial lung disease 76.72 10.73 160 185562 64841 32262963
Oxygen saturation decreased 76.07 10.73 503 185219 47596 32280208
Malaise 75.92 10.73 1427 184295 175711 32152093
Respiratory rate increased 75.61 10.73 166 185556 9191 32318613
Upper-airway cough syndrome 75.36 10.73 92 185630 3091 32324713
Vital capacity decreased 75.12 10.73 41 185681 409 32327395
Intentional overdose 75.06 10.73 76 185646 41525 32286279
Drug resistance 73.60 10.73 20 185702 22945 32304859
Circumstance or information capable of leading to device use error 71.27 10.73 19 185703 10 32327794
Lung hyperinflation 71.15 10.73 52 185670 894 32326910
White blood cell count decreased 71.06 10.73 274 185448 90924 32236880
Heart rate increased 69.55 10.73 443 185279 41385 32286419
Coma 69.05 10.73 85 185637 42527 32285277
Pyrexia 68.72 10.73 1352 184370 318616 32009188
Bronchial disorder 68.63 10.73 57 185665 1191 32326613
Bronchial hyperreactivity 68.38 10.73 63 185659 1519 32326285
Rhinorrhoea 68.02 10.73 286 185436 22700 32305104
Treatment failure 67.90 10.73 74 185648 39089 32288715
Sinus pain 67.16 10.73 49 185673 840 32326964
Dust allergy 66.45 10.73 41 185681 524 32327280
Renal failure 66.04 10.73 473 185249 134005 32193799
Nasal obstruction 65.56 10.73 47 185675 783 32327021
Upper respiratory tract infection 65.31 10.73 337 185385 29136 32298668
Throat irritation 64.27 10.73 160 185562 9618 32318186
Respiratory failure 63.53 10.73 911 184811 106271 32221533
Hospitalisation 63.42 10.73 488 185234 48483 32279321
Blood creatinine increased 62.03 10.73 310 185412 95822 32231982
Chronic sinusitis 61.99 10.73 64 185658 1781 32326023
Lung consolidation 60.68 10.73 110 185612 5293 32322511
Septic shock 60.59 10.73 197 185525 68792 32259012
Acute kidney injury 60.00 10.73 1250 184472 292218 32035586
Disseminated intravascular coagulation 59.38 10.73 29 185693 23147 32304657
Product container issue 59.12 10.73 45 185677 825 32326979
Gastrooesophageal reflux disease 58.42 10.73 369 185353 34369 32293435
Sinus congestion 57.77 10.73 103 185619 4892 32322912
Neuropathy peripheral 57.60 10.73 235 185487 76747 32251057
Neutrophil count decreased 57.35 10.73 114 185608 47025 32280779
Bronchial secretion retention 57.20 10.73 48 185674 1018 32326786
Forced vital capacity decreased 56.98 10.73 42 185680 732 32327072
Respiratory distress 56.57 10.73 370 185352 34876 32292928
Respiratory tract infection 56.51 10.73 222 185500 17083 32310721
Obstruction 54.90 10.73 60 185662 1785 32326019
Stomatitis 54.55 10.73 91 185631 40138 32287666
Pneumocystis jirovecii pneumonia 54.12 10.73 20 185702 18850 32308954
Bronchospasm paradoxical 53.74 10.73 20 185702 70 32327734
Lung disorder 53.36 10.73 353 185369 33401 32294403
Rheumatoid arthritis 53.10 10.73 109 185613 44435 32283369
Lung diffusion test decreased 52.45 10.73 38 185684 644 32327160
Lower respiratory tract congestion 52.28 10.73 48 185674 1152 32326652
Stress 52.05 10.73 271 185451 23511 32304293
Cerebral infarction 51.48 10.73 49 185673 27565 32300239
Body temperature decreased 51.35 10.73 159 185563 10855 32316949
Rhonchi 51.02 10.73 58 185664 1804 32326000
Sensitivity to weather change 50.81 10.73 53 185669 1493 32326311
Drug intolerance 50.22 10.73 135 185587 50100 32277704
Inhalation therapy 49.67 10.73 16 185706 31 32327773
Oropharyngeal pain 49.63 10.73 328 185394 31024 32296780
Acute respiratory failure 49.45 10.73 307 185415 28421 32299383
Throat tightness 48.87 10.73 125 185597 7641 32320163
Sleep terror 48.68 10.73 40 185682 823 32326981
Bronchiolitis 48.66 10.73 71 185651 2842 32324962
Pulmonary mass 47.88 10.73 163 185559 11697 32316107
Dyspnoea at rest 47.81 10.73 76 185646 3283 32324521
Peritonitis 47.31 10.73 35 185687 22295 32305509
Status asthmaticus 47.25 10.73 28 185694 331 32327473
Increased bronchial secretion 46.81 10.73 54 185668 1707 32326097
Cerebral haemorrhage 46.74 10.73 79 185643 34668 32293136
Spirometry abnormal 46.72 10.73 30 185692 413 32327391
Rhabdomyolysis 46.24 10.73 212 185510 67053 32260751
Hepatotoxicity 45.44 10.73 27 185695 19310 32308494
Myelosuppression 43.93 10.73 7 185715 11669 32316135
Device ineffective 43.17 10.73 14 185708 28 32327776
Blood lactate dehydrogenase increased 42.66 10.73 37 185685 21768 32306036
Drug reaction with eosinophilia and systemic symptoms 42.65 10.73 75 185647 32410 32295394
Peak expiratory flow rate decreased 41.93 10.73 20 185702 146 32327658
Appendicolith 41.50 10.73 69 185653 3096 32324708
Seasonal allergy 41.38 10.73 93 185629 5231 32322573
Restrictive pulmonary disease 41.35 10.73 42 185680 1146 32326658
Anaphylactic reaction 40.92 10.73 304 185418 29868 32297936
Rhinitis 40.82 10.73 91 185631 5090 32322714
Cardiac failure 40.46 10.73 332 185390 91341 32236463
Serotonin syndrome 40.46 10.73 30 185692 19087 32308717
Multiple organ dysfunction syndrome 40.21 10.73 234 185488 69620 32258184
Agranulocytosis 39.99 10.73 45 185677 23432 32304372
Device information output issue 39.98 10.73 15 185707 54 32327750
Hypoventilation 38.73 10.73 69 185653 3275 32324529
Allergy to animal 38.63 10.73 22 185700 240 32327564
Increased viscosity of bronchial secretion 38.63 10.73 22 185700 240 32327564
Disease progression 38.14 10.73 315 185407 86547 32241257
Osteonecrosis of jaw 38.14 10.73 32 185690 19134 32308670
Rales 37.66 10.73 114 185608 7687 32320117
Painful respiration 37.62 10.73 42 185680 1280 32326524
Respiratory symptom 36.80 10.73 37 185685 997 32326807
C-reactive protein increased 36.49 10.73 146 185576 47956 32279848
Product use in unapproved indication 36.16 10.73 321 185401 86883 32240921
Smoke sensitivity 35.92 10.73 19 185703 177 32327627
Palmar-plantar erythrodysaesthesia syndrome 35.60 10.73 23 185699 15726 32312078
Progressive multifocal leukoencephalopathy 35.22 10.73 6 185716 9525 32318279
Blood pressure systolic increased 35.18 10.73 194 185528 17202 32310602
Tubulointerstitial nephritis 35.04 10.73 36 185686 19541 32308263
Overdose 35.03 10.73 323 185399 86754 32241050
Thrombotic microangiopathy 34.97 10.73 6 185716 9476 32318328
Death 34.96 10.73 1808 183914 380709 31947095
Drug-induced liver injury 34.93 10.73 52 185670 24011 32303793
Sleep apnoea syndrome 34.89 10.73 205 185517 18609 32309195
Plasma cell myeloma 34.78 10.73 190 185532 57424 32270380
Acute myeloid leukaemia 34.61 10.73 35 185687 19139 32308665
Product complaint 34.06 10.73 91 185631 5712 32322092
Forced expiratory flow decreased 33.64 10.73 18 185704 172 32327632
Altered state of consciousness 33.44 10.73 46 185676 21951 32305853
Posterior reversible encephalopathy syndrome 33.31 10.73 7 185715 9569 32318235
Hyperthermia 33.16 10.73 10 185712 10718 32317086
Crepitations 33.10 10.73 62 185660 3060 32324744
Peritonitis bacterial 32.99 10.73 15 185707 12481 32315323
Conjunctivitis allergic 32.99 10.73 30 185692 711 32327093
Hepatocellular injury 32.74 10.73 59 185663 25259 32302545
Sputum abnormal 31.87 10.73 25 185697 480 32327324
Circumstance or information capable of leading to medication error 31.76 10.73 46 185676 1829 32325975
Hepatitis 31.74 10.73 54 185668 23639 32304165
Neuroleptic malignant syndrome 31.51 10.73 32 185690 17463 32310341
Blood cholesterol 31.46 10.73 17 185705 166 32327638
Sopor 31.18 10.73 14 185708 11735 32316069
Atelectasis 31.07 10.73 183 185539 16625 32311179
Hepatic failure 30.54 10.73 103 185619 35577 32292227
Hormone receptor positive breast cancer 30.52 10.73 10 185712 21 32327783
Poisoning 30.08 10.73 13 185709 11145 32316659
Dermatitis atopic 29.99 10.73 52 185670 2415 32325389
Product delivery mechanism issue 29.80 10.73 16 185706 154 32327650
Transplant rejection 29.70 10.73 10 185712 9989 32317815
Pneumonia lipoid 29.56 10.73 12 185710 56 32327748
Decreased activity 29.44 10.73 70 185652 4086 32323718
Chest pain 29.30 10.73 922 184800 123215 32204589
Nasal disorder 29.18 10.73 40 185682 1510 32326294
Foetal exposure during pregnancy 29.08 10.73 129 185593 41172 32286632
Gamma-glutamyltransferase increased 29.07 10.73 85 185637 30697 32297107
Polyneuropathy 28.93 10.73 20 185702 13195 32314609
Vocal cord dysfunction 28.90 10.73 17 185705 198 32327606
Increased upper airway secretion 28.68 10.73 43 185679 1764 32326040
Respiration abnormal 28.58 10.73 57 185665 2948 32324856
Choking 28.31 10.73 79 185643 5087 32322717
Hyperbilirubinaemia 28.05 10.73 36 185686 17694 32310110
Factitious disorder 28.05 10.73 11 185711 46 32327758
Tachypnoea 28.04 10.73 178 185544 16605 32311199
Respiratory tract irritation 27.62 10.73 15 185707 148 32327656
Snoring 27.44 10.73 57 185665 3036 32324768
Pathogen resistance 27.40 10.73 10 185712 9500 32318304
Airway remodelling 27.37 10.73 15 185707 151 32327653
Liver disorder 27.35 10.73 91 185631 31563 32296241
Pulmonary congestion 27.28 10.73 148 185574 13043 32314761
Suicide attempt 27.19 10.73 119 185603 38125 32289679
Eosinophil count 27.03 10.73 15 185707 155 32327649
Graft versus host disease 26.96 10.73 14 185708 10792 32317012
Suffocation feeling 26.96 10.73 25 185697 608 32327196
Total lung capacity decreased 26.80 10.73 26 185696 670 32327134
Respiratory syncytial virus infection 26.71 10.73 64 185658 3754 32324050
Cytopenia 26.69 10.73 12 185710 10052 32317752
Breath alcohol test positive 26.51 10.73 8 185714 11 32327793
Wolff-Parkinson-White syndrome 26.23 10.73 16 185706 200 32327604
Swollen tongue 26.19 10.73 150 185572 13489 32314315
Depressed level of consciousness 26.16 10.73 132 185590 40715 32287089
Cystic fibrosis respiratory infection suppression 26.08 10.73 20 185702 371 32327433
Nightmare 26.07 10.73 146 185576 13020 32314784
Eye swelling 25.94 10.73 116 185606 9456 32318348
Nasal inflammation 25.87 10.73 17 185705 244 32327560
Synovitis 25.82 10.73 15 185707 10863 32316941
Pancreatitis 25.76 10.73 121 185601 38030 32289774
Ear infection 25.68 10.73 106 185616 8342 32319462
Neurotoxicity 25.54 10.73 29 185693 15041 32312763
Perfume sensitivity 25.44 10.73 13 185709 112 32327692
Pickwickian syndrome 25.34 10.73 12 185710 86 32327718
Neoplasm progression 25.25 10.73 46 185676 19612 32308192
Infective exacerbation of chronic obstructive airways disease 25.14 10.73 41 185681 1810 32325994
Viral infection 25.11 10.73 169 185553 16081 32311723
Sepsis 25.06 10.73 703 185019 158131 32169673
Lymph node calcification 24.99 10.73 16 185706 219 32327585
Eosinophilic bronchitis 24.80 10.73 14 185708 150 32327654
Encephalopathy 24.72 10.73 106 185616 34151 32293653
Spinal muscular atrophy 24.65 10.73 18 185704 309 32327495
Sneezing 24.61 10.73 71 185651 4660 32323144
Mean platelet volume increased 24.61 10.73 21 185701 456 32327348
Rhinitis allergic 24.53 10.73 54 185668 2995 32324809
Food allergy 24.43 10.73 30 185692 1014 32326790
Victim of child abuse 24.24 10.73 26 185696 757 32327047
Cardio-respiratory arrest 24.13 10.73 204 185518 55785 32272019
Right atrial hypertrophy 24.12 10.73 18 185704 320 32327484
Herpes zoster 24.00 10.73 99 185623 32242 32295562
Blood immunoglobulin E decreased 23.92 10.73 10 185712 51 32327753
Haemophagocytic lymphohistiocytosis 23.71 10.73 18 185704 11317 32316487
Alanine aminotransferase increased 23.62 10.73 311 185411 78168 32249636
Chest X-ray abnormal 23.62 10.73 63 185659 3950 32323854
Hypercapnia 23.42 10.73 64 185658 4071 32323733
Neurodevelopmental disorder 23.30 10.73 14 185708 170 32327634
Foetal malformation 23.05 10.73 13 185709 139 32327665
Brain oedema 23.00 10.73 24 185698 12936 32314868
Wrong technique in device usage process 22.96 10.73 32 185690 1227 32326577
Chronic respiratory failure 22.67 10.73 33 185689 1318 32326486
Pancreatitis acute 22.66 10.73 80 185642 27255 32300549
Nasal discharge discolouration 22.50 10.73 16 185706 263 32327541
Skin discomfort 22.32 10.73 10 185712 62 32327742
Colitis 22.15 10.73 109 185613 33842 32293962
Shock haemorrhagic 22.15 10.73 17 185705 10628 32317176
Swelling face 22.13 10.73 211 185511 22294 32305510
Product taste abnormal 21.81 10.73 31 185691 1211 32326593
Lip swelling 21.77 10.73 144 185578 13621 32314183
Psoriasis 21.75 10.73 164 185558 45959 32281845
Haemoglobin decreased 21.70 10.73 519 185203 119152 32208652
Sputum purulent 21.65 10.73 20 185702 484 32327320
Eye pruritus 21.61 10.73 66 185656 4472 32323332
Obesity 21.57 10.73 115 185607 10067 32317737
Tumour lysis syndrome 21.54 10.73 31 185691 14516 32313288
Mycotic allergy 21.46 10.73 16 185706 284 32327520
Mite allergy 21.22 10.73 17 185705 337 32327467
Epstein-Barr virus infection 21.22 10.73 7 185715 7083 32320721
Blood bilirubin increased 21.21 10.73 132 185590 38652 32289152
Aspartate aminotransferase increased 21.20 10.73 260 185462 66169 32261635
Sleep disorder 21.18 10.73 240 185482 26512 32301292
Nasal oedema 21.18 10.73 17 185705 338 32327466
Lung neoplasm malignant 21.17 10.73 160 185562 15803 32312001
Diffuse large B-cell lymphoma 21.06 10.73 11 185711 8451 32319353
Product administered to patient of inappropriate age 20.68 10.73 48 185674 2758 32325046
Myelodysplastic syndrome 20.66 10.73 53 185669 19985 32307819
Seizure 20.64 10.73 444 185278 103410 32224394
Dysphonia 20.37 10.73 194 185528 20490 32307314
Nephropathy toxic 20.23 10.73 23 185699 11923 32315881
Psoriatic arthropathy 20.20 10.73 45 185677 17815 32309989
Forced expiratory volume 20.19 10.73 10 185712 80 32327724
Asthma exercise induced 20.05 10.73 11 185711 111 32327693
Drug level increased 20.03 10.73 54 185668 20026 32307778
Lymphocyte count abnormal 19.82 10.73 22 185700 666 32327138
Haematochezia 19.65 10.73 137 185585 39071 32288733
Anxiety 19.56 10.73 701 185021 95304 32232500
Carbon dioxide increased 19.52 10.73 27 185695 1028 32326776
Hepatitis B 19.44 10.73 6 185716 6335 32321469
Attention-seeking behaviour 19.42 10.73 8 185714 39 32327765
Kidney transplant rejection 19.42 10.73 10 185712 7745 32320059
Hepatocellular carcinoma 19.40 10.73 18 185704 10252 32317552
Proteinuria 19.40 10.73 44 185678 17311 32310493
Cystitis haemorrhagic 19.39 10.73 3 185719 5111 32322693
Respiratory tract infection bacterial 19.29 10.73 21 185701 622 32327182
Cor pulmonale acute 19.29 10.73 14 185708 238 32327566
Disorientation 19.20 10.73 112 185610 33313 32294491
Venoocclusive liver disease 19.19 10.73 9 185713 7356 32320448
Low birth weight baby 19.09 10.73 8 185714 6986 32320818
Metabolic acidosis 19.05 10.73 145 185577 40554 32287250
General physical health deterioration 18.98 10.73 507 185215 114752 32213052
Viral upper respiratory tract infection 18.84 10.73 46 185676 2731 32325073
Bronchial irritation 18.70 10.73 7 185715 25 32327779
Hypopnoea 18.63 10.73 30 185692 1310 32326494
Myocardial infarction 18.61 10.73 561 185161 125115 32202689
Hepatitis cholestatic 18.61 10.73 12 185710 8213 32319591
Total lung capacity abnormal 18.58 10.73 12 185710 167 32327637
Pharyngeal oedema 18.57 10.73 80 185642 6416 32321388
Multiple allergies 18.54 10.73 41 185681 2281 32325523
Renal injury 18.54 10.73 25 185697 12030 32315774
Tracheal disorder 18.49 10.73 11 185711 131 32327673
Therapy partial responder 18.45 10.73 3 185719 4927 32322877
Hypotension 18.43 10.73 1028 184694 215082 32112722
Right atrial enlargement 18.33 10.73 14 185708 258 32327546
Hyperkalaemia 18.31 10.73 284 185438 69466 32258338
Febrile bone marrow aplasia 18.07 10.73 13 185709 8402 32319402
Decreased gait velocity 17.93 10.73 11 185711 139 32327665
Panic reaction 17.93 10.73 32 185690 1521 32326283
Lung opacity 17.89 10.73 31 185691 1439 32326365
Cytomegalovirus viraemia 17.87 10.73 8 185714 6719 32321085
Jaundice 17.79 10.73 118 185604 34040 32293764
C-reactive protein abnormal 17.79 10.73 7 185715 6349 32321455
Sensory integrative dysfunction 17.71 10.73 7 185715 30 32327774
Squamous cell carcinoma 17.63 10.73 22 185700 10946 32316858
Social avoidant behaviour 17.61 10.73 49 185673 3150 32324654
Cerebral artery thrombosis 17.52 10.73 20 185702 625 32327179
Cholestasis 17.51 10.73 87 185635 26946 32300858
Somnolence 17.50 10.73 455 185267 103342 32224462
Confusional state 17.41 10.73 655 185067 142460 32185344
Therapy non-responder 17.41 10.73 112 185610 32542 32295262
Acute generalised exanthematous pustulosis 17.36 10.73 8 185714 6605 32321199
Drug eruption 17.32 10.73 54 185668 19112 32308692
Device related infection 17.31 10.73 49 185673 17884 32309920
Myoclonus 17.25 10.73 36 185686 14593 32313211
Palpitations 17.19 10.73 295 185427 35674 32292130
Trisomy 18 17.19 10.73 13 185709 236 32327568
Blood urine 17.18 10.73 17 185705 449 32327355
Shock 17.16 10.73 75 185647 24039 32303765
Upper respiratory fungal infection 17.11 10.73 10 185712 115 32327689
Cystic fibrosis related diabetes 17.09 10.73 11 185711 152 32327652
Stridor 17.02 10.73 41 185681 2413 32325391
Sarcopenia 16.94 10.73 15 185707 343 32327461
Respiratory syncytial virus bronchiolitis 16.92 10.73 16 185706 399 32327405
Rhinalgia 16.89 10.73 16 185706 400 32327404
Tracheostomy malfunction 16.82 10.73 8 185714 58 32327746
Ileus 16.79 10.73 43 185679 16222 32311582
Eosinophilia 16.74 10.73 217 185505 24741 32303063
Blood alkaline phosphatase increased 16.73 10.73 111 185611 32021 32295783
Influenza B virus test positive 16.73 10.73 9 185713 87 32327717
Bed bug infestation 16.68 10.73 4 185718 0 32327804
Renal tubular necrosis 16.68 10.73 42 185680 15936 32311868
Red cell distribution width increased 16.65 10.73 64 185658 4873 32322931
Toxic epidermal necrolysis 16.58 10.73 61 185661 20532 32307272
Aptyalism 16.56 10.73 14 185708 300 32327504
Acute graft versus host disease in skin 16.49 10.73 4 185718 4953 32322851
Tracheomalacia 16.44 10.73 11 185711 163 32327641
Mycobacterium avium complex infection 16.37 10.73 45 185677 2872 32324932
Paranasal sinus discomfort 16.36 10.73 21 185701 743 32327061
Hypersensitivity 16.35 10.73 439 185283 57319 32270485
Accessory spleen 16.32 10.73 11 185711 165 32327639
Blood pressure increased 16.30 10.73 580 185142 78774 32249030
Mucormycosis 16.20 10.73 6 185716 5648 32322156
Chronic kidney disease 16.18 10.73 148 185574 39827 32287977
Enterococcal infection 16.17 10.73 17 185705 9130 32318674
Aspirin-exacerbated respiratory disease 16.13 10.73 16 185706 424 32327380
Throat clearing 16.11 10.73 14 185708 312 32327492
Humidity intolerance 16.10 10.73 7 185715 40 32327764
Rhinovirus infection 16.01 10.73 49 185673 3324 32324480
Toxic skin eruption 15.99 10.73 26 185696 11588 32316216
Dehydration 15.95 10.73 589 185133 128369 32199435
Foreign body aspiration 15.88 10.73 11 185711 173 32327631
Second primary malignancy 15.88 10.73 10 185712 6931 32320873
Mood swings 15.81 10.73 90 185632 8075 32319729
Nasal discomfort 15.76 10.73 27 185695 1242 32326562
Hyperuricaemia 15.70 10.73 14 185708 8127 32319677
Coronary artery disease 15.68 10.73 195 185527 49511 32278293
Congenital hiatus hernia 15.68 10.73 13 185709 271 32327533
Parathyroid gland enlargement 15.44 10.73 9 185713 103 32327701
Respiratory acidosis 15.43 10.73 58 185664 4370 32323434
Animal scratch 15.41 10.73 11 185711 182 32327622
Blood creatine phosphokinase increased 15.27 10.73 176 185546 45300 32282504
Klebsiella infection 15.19 10.73 14 185708 7998 32319806
Anuria 15.17 10.73 24 185698 10813 32316991
Haematuria 15.16 10.73 190 185532 48171 32279633
Sinus operation 15.14 10.73 19 185703 657 32327147
Extrapyramidal disorder 15.13 10.73 28 185694 11867 32315937
Oropharyngeal discomfort 15.06 10.73 37 185685 2205 32325599
Ventricular hyperkinesia 15.06 10.73 12 185710 236 32327568
Infective exacerbation of bronchiectasis 15.02 10.73 16 185706 462 32327342
Withdrawal syndrome 15.01 10.73 29 185693 12093 32315711
Hypercalcaemia 14.91 10.73 36 185686 13858 32313946
Subdural haematoma 14.85 10.73 61 185661 19892 32307912
Polyp 14.82 10.73 49 185673 3463 32324341
Gait disturbance 14.76 10.73 348 185374 80060 32247744
Renal disorder 14.67 10.73 84 185638 25099 32302705
Communication disorder 14.64 10.73 40 185682 2544 32325260
Haemolytic anaemia 14.63 10.73 24 185698 10660 32317144
Parkinsonism 14.62 10.73 14 185708 7855 32319949
Nervous system disorder 14.61 10.73 37 185685 14012 32313792
Incorrect dose administered 14.53 10.73 281 185441 34747 32293057
Product cleaning inadequate 14.52 10.73 5 185717 13 32327791
Restlessness 14.49 10.73 83 185639 24798 32303006
Oesophageal polyp 14.46 10.73 7 185715 53 32327751
Encephalitis toxic 14.40 10.73 12 185710 252 32327552
Cystic fibrosis lung 14.39 10.73 8 185714 83 32327721
Mycobacterium test positive 14.33 10.73 14 185708 364 32327440
Lymphopenia 14.32 10.73 39 185683 14417 32313387
Personal relationship issue 14.24 10.73 12 185710 256 32327548
Cortisol decreased 14.22 10.73 22 185700 928 32326876
Migraine 14.19 10.73 132 185590 13853 32313951
Emotional disorder of childhood 14.13 10.73 6 185716 32 32327772
Urticaria 14.10 10.73 443 185279 59171 32268633
Pancreatic carcinoma 14.06 10.73 16 185706 8290 32319514
Colon cancer 14.03 10.73 18 185704 8848 32318956
Acute myocardial infarction 13.99 10.73 226 185496 54923 32272881
Epidural lipomatosis 13.98 10.73 18 185704 639 32327165
Infusion related reaction 13.97 10.73 180 185542 45419 32282385
Lacrimal disorder 13.92 10.73 13 185709 319 32327485
Nausea 13.86 10.73 1613 184109 319236 32008568
Aplastic anaemia 13.84 10.73 13 185709 7360 32320444
Appendicitis 13.84 10.73 93 185629 8844 32318960
Superinfection 13.83 10.73 33 185689 1931 32325873
Cytokine release syndrome 13.80 10.73 36 185686 13499 32314305
Oliguria 13.78 10.73 16 185706 8218 32319586
Anosmia 13.78 10.73 36 185686 2229 32325575
Transaminases increased 13.78 10.73 85 185637 24943 32302861
Urinary tract infection 13.76 10.73 350 185372 79721 32248083
Akathisia 13.64 10.73 12 185710 7013 32320791
Fall 13.63 10.73 951 184771 195250 32132554
Musculoskeletal stiffness 13.56 10.73 151 185571 39113 32288691
Poisoning deliberate 13.49 10.73 10 185712 6365 32321439
Metastases to liver 13.49 10.73 34 185688 12898 32314906
Tracheitis 13.45 10.73 18 185704 664 32327140
Anger 13.43 10.73 115 185607 11789 32316015
Osteopenia 13.43 10.73 59 185663 4773 32323031
Hemiparesis 13.39 10.73 45 185677 15562 32312242
Cerebrovascular accident 13.35 10.73 383 185339 85937 32241867
Small airways disease 13.29 10.73 6 185716 38 32327766
Disease complication 13.25 10.73 41 185681 2798 32325006
Schizophrenia 13.15 10.73 23 185699 9961 32317843
Wrong technique in product usage process 13.13 10.73 277 185445 34782 32293022
Hot flush 13.13 10.73 142 185580 15504 32312300
Bradyphrenia 13.12 10.73 5 185717 4624 32323180
Cytomegalovirus test positive 13.08 10.73 3 185719 3859 32323945
Pleural thickening 13.06 10.73 13 185709 346 32327458
Blebitis 13.05 10.73 4 185718 6 32327798
Chest injury 12.92 10.73 28 185694 1536 32326268
Post-tussive vomiting 12.92 10.73 5 185717 20 32327784
Basal cell carcinoma 12.89 10.73 54 185668 17514 32310290
Lacunar stroke 12.86 10.73 9 185713 144 32327660
Hepatic steatosis 12.85 10.73 48 185674 16085 32311719
Accidental exposure to product 12.85 10.73 28 185694 11174 32316630
Impaired quality of life 12.84 10.73 36 185686 2324 32325480
Chronic respiratory disease 12.81 10.73 7 185715 70 32327734
Crying 12.77 10.73 67 185655 5829 32321975
Haemorrhage 12.75 10.73 202 185520 49246 32278558
Oesophageal carcinoma 12.72 10.73 52 185670 4074 32323730
Virologic failure 12.71 10.73 3 185719 3784 32324020
BK virus infection 12.67 10.73 6 185716 4875 32322929
Dyskinesia 12.56 10.73 81 185641 23522 32304282
Encephalitis 12.55 10.73 13 185709 7031 32320773
Gastroenteritis viral 12.53 10.73 69 185653 6114 32321690
Emergency care examination 12.51 10.73 3 185719 0 32327804
Occupational asthma 12.51 10.73 3 185719 0 32327804
Coronary artery stenosis 12.50 10.73 23 185699 9770 32318034
Blood urea increased 12.41 10.73 121 185601 32152 32295652
Nervous system neoplasm 12.40 10.73 9 185713 153 32327651
Hypoalbuminaemia 12.40 10.73 31 185691 11791 32316013
Panic attack 12.37 10.73 93 185629 9168 32318636
FEV1/FVC ratio decreased 12.37 10.73 5 185717 23 32327781
Lung hernia 12.32 10.73 7 185715 76 32327728
Blood gases abnormal 12.28 10.73 12 185710 312 32327492
Hernia pain 12.26 10.73 11 185711 256 32327548
Osteonecrosis 12.26 10.73 51 185671 16571 32311233
Weaning failure 12.22 10.73 11 185711 257 32327547
Electrocardiogram QT shortened 12.20 10.73 9 185713 157 32327647
Alveolar bone resorption 12.20 10.73 5 185717 24 32327780
Social problem 12.08 10.73 20 185702 894 32326910
Sinus disorder 12.06 10.73 72 185650 6572 32321232
Brain scan abnormal 12.05 10.73 18 185704 736 32327068
Rubber sensitivity 12.04 10.73 8 185714 117 32327687
Pharyngeal paraesthesia 11.98 10.73 14 185708 449 32327355
Oxygen consumption increased 11.91 10.73 25 185697 1341 32326463
Intentional device misuse 11.91 10.73 11 185711 266 32327538
Tendon calcification 11.91 10.73 6 185716 50 32327754
Osteoporosis 11.87 10.73 114 185608 12068 32315736
Aphasia 11.85 10.73 70 185652 20758 32307046
Graft versus host disease in skin 11.81 10.73 3 185719 3601 32324203
Psychotic disorder 11.75 10.73 80 185642 22940 32304864
Squamous cell carcinoma of skin 11.74 10.73 24 185698 9802 32318002
Vascular shunt 11.73 10.73 5 185717 27 32327777
Benign prostatic hyperplasia 11.70 10.73 115 185607 12249 32315555
Accelerated idioventricular rhythm 11.65 10.73 7 185715 85 32327719
Pulmonary hypertension 11.64 10.73 173 185549 20321 32307483
Endophthalmitis 11.64 10.73 4 185718 3945 32323859
Deep vein thrombosis 11.62 10.73 276 185446 63437 32264367
Anal abscess 11.54 10.73 9 185713 5581 32322223
B-cell lymphoma 11.50 10.73 6 185716 4613 32323191
Adrenocortical insufficiency acute 11.45 10.73 25 185697 1379 32326425
Metastases to lung 11.44 10.73 19 185703 8398 32319406
Rhinitis perennial 11.43 10.73 8 185714 128 32327676
Expiratory reserve volume decreased 11.43 10.73 6 185716 55 32327749
Carcinoid tumour of the gastrointestinal tract 11.43 10.73 6 185716 55 32327749
Bronchopulmonary aspergillosis 11.38 10.73 40 185682 13647 32314157
Papule 11.38 10.73 3 185719 3512 32324292
Hypochromasia 11.36 10.73 12 185710 343 32327461
Peripheral swelling 11.32 10.73 488 185234 67857 32259947
Adenoidectomy 11.31 10.73 7 185715 90 32327714
Intentional self-injury 11.31 10.73 41 185681 13859 32313945
Renal tubular disorder 11.22 10.73 8 185714 5194 32322610
Bradycardia 11.20 10.73 317 185405 71245 32256559
Malpositioned teeth 11.16 10.73 5 185717 31 32327773
Haemophilus infection 11.16 10.73 21 185701 1040 32326764
Resuscitation 11.13 10.73 24 185698 1312 32326492
Discomfort 11.12 10.73 139 185583 15716 32312088
Paraneoplastic rash 11.11 10.73 7 185715 93 32327711
Ocular discomfort 11.11 10.73 28 185694 1696 32326108
Pneumococcal sepsis 11.09 10.73 19 185703 874 32326930
Gastric haemorrhage 11.07 10.73 25 185697 9851 32317953
Lupus pneumonitis 11.07 10.73 6 185716 59 32327745
Flour sensitivity 10.98 10.73 6 185716 60 32327744
Exposure to fungus 10.97 10.73 4 185718 13 32327791
Blood immunoglobulin E abnormal 10.97 10.73 4 185718 13 32327791
Contraindicated product administered 10.91 10.73 64 185658 19012 32308792
Incorrect dose administered by product 10.90 10.73 5 185717 33 32327771
Upper respiratory tract congestion 10.90 10.73 18 185704 803 32327001
Grunting 10.87 10.73 12 185710 361 32327443
Dyslipidaemia 10.86 10.73 14 185708 6869 32320935
Hypertrophic osteoarthropathy 10.86 10.73 7 185715 97 32327707
Walking aid user 10.84 10.73 26 185696 1526 32326278
Prolonged expiration 10.84 10.73 9 185713 188 32327616
Apnoeic attack 10.83 10.73 11 185711 300 32327504
Atopy 10.83 10.73 8 185714 140 32327664
Rash maculo-papular 10.80 10.73 105 185617 27917 32299887
Multiple sclerosis relapse 10.78 10.73 33 185689 11748 32316056
Pigment dispersion syndrome 10.75 10.73 4 185718 14 32327790
Sputum retention 10.74 10.73 14 185708 503 32327301

Pharmacologic Action:

SourceCodeDescription
ATC R03AC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03CC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
ATC R03AK04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
FDA MoA N0000009922 Adrenergic beta2-Agonists
CHEBI has role CHEBI:35522 beta-adrenergic receptor agonist
CHEBI has role CHEBI:35523 bronchodilator agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D015149 Tocolytic Agents
FDA EPC N0000175779 beta2-Adrenergic Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bronchospasm indication 4386001
Acute exacerbation of asthma indication 708038006
Bronchospasm Prevention indication
Exercise-Induced Bronchospasm Prevention indication
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Ketoacidosis contraindication 56051008
Metabolic acidosis contraindication 59455009
Diabetes mellitus contraindication 73211009 DOID:9351
Paradoxical bronchospasm contraindication 102578005
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Myocardial ischemia contraindication 414795007 DOID:3393
Congenital long QT syndrome contraindication 442917000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.07 acidic
pKa2 9.46 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST Ki 5.95 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.61 PDSP
Beta-2 adrenergic receptor GPCR Kd 5.94 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.28 CHEMBL

External reference:

IDSource
4018796 VUID
N0000147099 NUI
D02147 KEGG_DRUG
51022-70-9 SECONDARY_CAS_RN
142153 RXNORM
C0001927 UMLSCUI
CHEBI:2549 CHEBI
68H PDB_CHEM_ID
CHEMBL714 ChEMBL_ID
DB01001 DRUGBANK_ID
CHEMBL1441059 ChEMBL_ID
CHEMBL1201026 ChEMBL_ID
2083 PUBCHEM_CID
558 IUPHAR_LIGAND_ID
2585 INN_ID
QF8SVZ843E UNII
3007 MMSL
30960 MMSL
4143 MMSL
4144 MMSL
46702 MMSL
d00749 MMSL
D000420 MESH_DESCRIPTOR_UI
001814 NDDF
001815 NDDF
372897005 SNOMEDCT_US
48474002 SNOMEDCT_US
91143003 SNOMEDCT_US
4018796 VANDF
4018797 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0742 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) ANDA 14 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 26 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0254-1007 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0255 TABLET 2 mg ORAL ANDA 23 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0572 TABLET 4 mg ORAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6991 SOLUTION 0.63 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6992 SOLUTION 1.25 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-8270 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 24 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0378-9671 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0472-0825 SYRUP 2 mg ORAL ANDA 22 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0487-0201 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-0301 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9501 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9901 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9904 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3467 SOLUTION 0.63 mg INTRABRONCHIAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3468 SOLUTION 1.25 mg INTRABRONCHIAL ANDA 23 sections
Combivent Respimat HUMAN PRESCRIPTION DRUG LABEL 2 0597-0024 SPRAY, METERED 100 ug RESPIRATORY (INHALATION) NDA 27 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0781-7146 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7155 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7296 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 16590-339 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 27 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 17856-0740 SYRUP 2 mg ORAL ANDA 19 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 21695-198 AEROSOL, METERED 90 ug ORAL ANDA 24 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-245 SOLUTION 5 mg RESPIRATORY (INHALATION) ANDA 18 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-332 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-350 SYRUP 2 mg ORAL ANDA 19 sections