salbutamol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 105 18559-94-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salbutamol
  • albuterol
  • sabumol
  • dl-Albuterol
  • dl-Salbutamol
  • albuterol sulfate
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
  • Molecular weight: 239.32
  • Formula: C13H21NO3
  • CLOGP: 0.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -2.05
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
10 mg Inhal.solution
12 mg O
12 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.23 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.92 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 1, 1981 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 5855.63 9.99 4834 303032 86708 46291488
Wheezing 2117.64 9.99 2161 305705 51225 46326971
Dyspnoea 1872.00 9.99 7513 300353 508035 45870161
Product quality issue 1451.21 9.99 1464 306402 34184 46344012
Chronic obstructive pulmonary disease 1204.16 9.99 1683 306183 55950 46322246
Poor quality device used 1100.42 9.99 442 307424 1670 46376526
Obstructive airways disorder 940.30 9.99 749 307117 12663 46365533
Cough 896.96 9.99 3439 304427 226810 46151386
Completed suicide 704.88 9.99 72 307794 145848 46232348
Forced expiratory volume decreased 671.46 9.99 419 307447 4685 46373511
Productive cough 667.54 9.99 1199 306667 49516 46328680
Blood count abnormal 569.50 9.99 645 307221 17233 46360963
Chest discomfort 567.05 9.99 1588 306278 88681 46289515
Infective pulmonary exacerbation of cystic fibrosis 559.36 9.99 507 307359 10300 46367896
Sputum discoloured 527.38 9.99 529 307337 12249 46365947
Pneumonia 506.55 9.99 4219 303647 372101 46006095
Toxicity to various agents 430.43 9.99 457 307409 211309 46166887
Bronchitis 409.79 9.99 1581 306285 104398 46273798
Rheumatoid arthritis 393.50 9.99 610 307256 239605 46138591
Sleep disorder due to a general medical condition 373.62 9.99 252 307614 3247 46374949
Lower respiratory tract infection 345.56 9.99 969 306897 54120 46324076
Treatment failure 338.32 9.99 97 307769 92990 46285206
Synovitis 266.02 9.99 42 307824 61033 46317163
Drug intolerance 260.61 9.99 353 307513 146696 46231500
Drug ineffective 256.28 9.99 3053 304813 674785 45703411
Off label use 250.99 9.99 1474 306392 378367 45999829
Product dose omission issue 238.39 9.99 1913 305953 166607 46211589
Drug abuse 219.67 9.99 72 307794 63336 46314860
Neutropenia 215.31 9.99 384 307482 142820 46235376
Sinusitis 209.12 9.99 1519 306347 128249 46249947
Bronchospasm 203.50 9.99 369 307497 15338 46362858
Intentional overdose 190.39 9.99 95 307771 64849 46313347
Thrombocytopenia 187.96 9.99 342 307524 126239 46251957
Middle insomnia 186.84 9.99 270 307596 9245 46368951
Febrile neutropenia 185.59 9.99 210 307656 94417 46283779
Systemic lupus erythematosus 179.85 9.99 103 307763 65077 46313119
Device delivery system issue 176.55 9.99 62 307804 143 46378053
Nasal congestion 170.64 9.99 699 307167 47414 46330782
Pulmonary function test decreased 170.34 9.99 165 307701 3655 46374541
Respiratory disorder 168.94 9.99 478 307388 26822 46351374
Hand deformity 166.93 9.99 17 307849 34557 46343639
Upper respiratory tract infection 166.22 9.99 844 307022 62712 46315484
Contraindicated product administered 162.75 9.99 172 307694 79775 46298421
Alopecia 161.69 9.99 540 307326 161874 46216322
Pancytopenia 153.84 9.99 201 307665 84857 46293339
Dyspnoea exertional 152.56 9.99 697 307169 49592 46328604
Drug interaction 150.95 9.99 757 307109 202337 46175859
Therapeutic product effect incomplete 149.14 9.99 954 306912 77199 46300997
Anaemia 146.93 9.99 1035 306831 254744 46123452
Breath sounds abnormal 146.55 9.99 217 307649 7598 46370598
Nasal polyps 145.48 9.99 119 307747 2091 46376105
Cystic fibrosis 145.43 9.99 149 307717 3539 46374657
Eosinophil count increased 132.78 9.99 208 307658 7658 46370538
Respiratory tract congestion 130.10 9.99 271 307595 12493 46365703
Arthropathy 128.24 9.99 226 307640 84474 46293722
Influenza 125.82 9.99 1013 306853 88257 46289939
Sleep apnoea syndrome 123.26 9.99 374 307492 21827 46356369
Malignant neoplasm progression 122.00 9.99 149 307717 64777 46313419
Leukopenia 118.02 9.99 167 307699 68176 46310020
Oxygen saturation decreased 117.33 9.99 820 307046 68344 46309852
No adverse event 115.62 9.99 490 307376 33741 46344455
Heart rate increased 115.52 9.99 867 306999 73924 46304272
Glossodynia 110.24 9.99 79 307787 44294 46333902
Rales 109.51 9.99 214 307652 9417 46368779
Blood immunoglobulin E increased 109.49 9.99 92 307774 1681 46376515
Emphysema 107.63 9.99 205 307661 8849 46369347
Bronchiectasis 103.50 9.99 205 307661 9111 46369085
Forced vital capacity decreased 103.29 9.99 68 307798 839 46377357
Hepatocellular injury 103.15 9.99 33 307833 29489 46348707
Food allergy 100.32 9.99 171 307695 6762 46371434
Product container issue 100.22 9.99 88 307778 1711 46376485
Dysphonia 99.61 9.99 509 307357 37905 46340291
Peak expiratory flow rate decreased 98.64 9.99 58 307808 577 46377619
Platelet count decreased 98.49 9.99 334 307532 99690 46278506
Therapeutic product effect decreased 97.83 9.99 253 307613 82348 46295848
Malaise 97.54 9.99 2866 305000 328366 46049830
Chest pain 96.68 9.99 1667 306199 174657 46203539
Reversible airways obstruction 94.92 9.99 54 307812 502 46377694
Respiratory rate increased 94.26 9.99 223 307643 11210 46366986
Sensitivity to weather change 93.30 9.99 146 307720 5370 46372826
Death 93.29 9.99 1604 306262 333944 46044252
Secretion discharge 93.10 9.99 195 307671 9024 46369172
Oropharyngeal pain 93.01 9.99 820 307046 73348 46304848
Hepatic function abnormal 92.66 9.99 56 307810 34365 46343831
White blood cell count decreased 91.11 9.99 405 307461 111826 46266370
Mucosal inflammation 90.94 9.99 74 307792 38902 46339294
Circumstance or information capable of leading to medication error 90.67 9.99 107 307759 2989 46375207
Nasopharyngitis 90.30 9.99 1472 306394 152526 46225670
Respiratory distress 89.20 9.99 432 307434 31484 46346712
Device malfunction 88.50 9.99 240 307626 13134 46365062
Haemoptysis 87.76 9.99 374 307492 25815 46352381
Cardio-respiratory arrest 86.81 9.99 164 307702 59705 46318491
Drug hypersensitivity 85.85 9.99 1113 306753 242712 46135484
Status asthmaticus 84.92 9.99 61 307805 875 46377321
Asthmatic crisis 83.74 9.99 73 307793 1405 46376791
Sopor 83.30 9.99 15 307851 19813 46358383
Maternal exposure during pregnancy 83.27 9.99 370 307496 102179 46276017
Ear pain 82.32 9.99 326 307540 21766 46356430
Hypersensitivity 82.31 9.99 1421 306445 148900 46229296
Lung hyperinflation 81.30 9.99 65 307801 1104 46377092
Anaphylactic reaction 81.04 9.99 614 307252 52498 46325698
Urticaria 80.68 9.99 1157 306709 116735 46261461
Bone marrow failure 78.84 9.99 49 307817 29620 46348576
Coma 78.46 9.99 167 307699 58182 46320014
Acute respiratory failure 78.29 9.99 390 307476 28748 46349448
Eosinophilic granulomatosis with polyangiitis 77.56 9.99 77 307789 1759 46376437
Respiration abnormal 76.93 9.99 120 307746 4401 46373795
Temperature regulation disorder 75.90 9.99 102 307764 3258 46374938
Eosinophil count abnormal 75.75 9.99 44 307822 427 46377769
Rhinitis allergic 75.53 9.99 151 307715 6757 46371439
Renal impairment 75.50 9.99 245 307621 74127 46304069
Infusion related reaction 74.65 9.99 378 307488 100830 46277366
Hepatic enzyme increased 73.94 9.99 283 307583 81504 46296692
Anxiety 73.91 9.99 1644 306222 180313 46197883
Suicide attempt 70.32 9.99 162 307704 54874 46323322
Gastrooesophageal reflux disease 70.29 9.99 775 307091 73569 46304627
Hypoventilation 69.81 9.99 109 307757 4001 46374195
Sputum increased 69.34 9.99 71 307795 1685 46376511
Seasonal allergy 68.80 9.99 219 307647 13115 46365081
Respiratory tract infection 68.74 9.99 384 307482 29588 46348608
Bronchospasm paradoxical 68.72 9.99 26 307840 80 46378116
Hepatotoxicity 68.28 9.99 40 307826 24969 46353227
Lip swelling 66.88 9.99 338 307528 25057 46353139
Blood pressure systolic increased 65.48 9.99 368 307498 28419 46349777
Abdominal discomfort 64.87 9.99 660 307206 150505 46227691
Humidity intolerance 64.76 9.99 37 307829 347 46377849
Respiratory symptom 64.74 9.99 74 307792 1996 46376200
Joint swelling 64.49 9.99 742 307124 165331 46212865
Arthralgia 64.30 9.99 1872 305994 362731 46015465
Cytomegalovirus infection 63.89 9.99 20 307846 18124 46360072
Alanine aminotransferase increased 63.73 9.99 333 307533 88118 46290078
Upper-airway cough syndrome 63.55 9.99 152 307714 7695 46370501
Musculoskeletal stiffness 62.98 9.99 383 307483 97610 46280586
Eosinophilic bronchitis 61.64 9.99 33 307833 269 46377927
Pericarditis 61.55 9.99 41 307825 23886 46354310
Hypoxia 61.33 9.99 566 307300 51272 46326924
Overdose 61.22 9.99 407 307459 101572 46276624
Femur fracture 60.36 9.99 94 307772 36903 46341293
Infective exacerbation of chronic obstructive airways disease 60.34 9.99 55 307811 1125 46377071
Total lung capacity increased 60.24 9.99 46 307820 728 46377468
Swollen tongue 59.56 9.99 363 307503 28869 46349327
Product cleaning inadequate 59.40 9.99 16 307850 6 46378190
Metastases to liver 58.36 9.99 28 307838 19557 46358639
Neutrophil count decreased 57.79 9.99 125 307741 43301 46334895
Toxic epidermal necrolysis 57.54 9.99 38 307828 22240 46355956
Drug reaction with eosinophilia and systemic symptoms 57.43 9.99 66 307800 29482 46348714
Aspartate aminotransferase increased 57.42 9.99 295 307571 78405 46299791
Neurotoxicity 56.29 9.99 11 307855 13706 46364490
Increased upper airway secretion 56.15 9.99 87 307779 3172 46375024
Throat tightness 55.97 9.99 277 307589 20362 46357834
C-reactive protein increased 55.39 9.99 199 307667 58391 46319805
Choking 55.11 9.99 150 307716 8226 46369970
Bronchial obstruction 55.03 9.99 55 307811 1267 46376929
Acute kidney injury 53.93 9.99 1165 306701 234690 46143506
Headache 53.92 9.99 3752 304114 474600 45903596
Bronchial wall thickening 53.14 9.99 44 307822 787 46377409
Restrictive pulmonary disease 52.87 9.99 52 307814 1174 46377022
Injection site pain 52.76 9.99 452 307414 106700 46271496
Posterior reversible encephalopathy syndrome 52.76 9.99 17 307849 15124 46363072
Altered state of consciousness 52.41 9.99 46 307820 23302 46354894
Pulmonary function test abnormal 52.30 9.99 53 307813 1242 46376954
Bronchial secretion retention 52.27 9.99 46 307820 897 46377299
Sedation complication 51.55 9.99 89 307777 3556 46374640
General physical health deterioration 51.51 9.99 501 307365 115268 46262928
Vital capacity decreased 51.43 9.99 37 307829 532 46377664
Multiple organ dysfunction syndrome 50.65 9.99 173 307693 51537 46326659
Disease progression 50.56 9.99 373 307493 90927 46287269
Lung disorder 49.31 9.99 469 307397 42835 46335361
Diarrhoea 49.29 9.99 3107 304759 556495 45821701
Dust allergy 49.26 9.99 35 307831 493 46377703
Osteonecrosis of jaw 49.20 9.99 95 307771 34307 46343889
Rhinorrhoea 48.82 9.99 505 307361 47160 46331036
Respiratory failure 48.19 9.99 886 306980 93930 46284266
Chronic sinusitis 47.98 9.99 104 307762 4929 46373267
Viral infection 47.50 9.99 352 307514 29883 46348313
Lower respiratory tract congestion 47.50 9.99 60 307806 1801 46376395
Hospitalisation 47.36 9.99 632 307234 62753 46315443
Cholestasis 47.12 9.99 65 307801 26828 46351368
Sinus disorder 46.85 9.99 225 307641 16338 46361858
Pneumocystis jirovecii pneumonia 46.67 9.99 21 307845 15227 46362969
Sputum purulent 46.44 9.99 41 307825 803 46377393
Palpitations 46.29 9.99 884 306982 94375 46283821
Cholecystitis chronic 45.82 9.99 163 307703 10336 46367860
Palmar-plantar erythrodysaesthesia syndrome 45.06 9.99 41 307825 20410 46357786
Coeliac disease 44.89 9.99 126 307740 7035 46371161
Bronchopulmonary aspergillosis allergic 44.61 9.99 38 307828 708 46377488
Prolonged expiration 44.38 9.99 29 307837 353 46377843
Stomatitis 43.31 9.99 268 307598 68029 46310167
Poisoning 43.26 9.99 19 307847 13975 46364221
Injection site reaction 42.95 9.99 166 307700 47683 46330513
Cerebral infarction 42.44 9.99 55 307811 23311 46354885
Decreased appetite 42.41 9.99 964 306902 192872 46185324
Body temperature increased 42.27 9.99 295 307571 24566 46353630
Inhalation therapy 42.11 9.99 16 307850 50 46378146
Somnolence 41.83 9.99 753 307113 155768 46222428
Drug-induced liver injury 41.81 9.99 64 307802 25304 46352892
Intentional self-injury 41.75 9.99 59 307807 24107 46354089
Perfume sensitivity 41.74 9.99 33 307833 551 46377645
Anuria 41.34 9.99 12 307854 11419 46366777
Impaired healing 40.88 9.99 116 307750 36627 46341569
Smoke sensitivity 40.71 9.99 24 307842 240 46377956
Agranulocytosis 40.52 9.99 52 307814 22133 46356063
Total lung capacity decreased 40.49 9.99 43 307823 1066 46377130
Serotonin syndrome 40.02 9.99 61 307805 24159 46354037
Disseminated intravascular coagulation 39.66 9.99 40 307826 18965 46359231
Throat irritation 39.61 9.99 326 307540 28575 46349621
Increased bronchial secretion 39.56 9.99 51 307815 1563 46376633
Rhonchi 39.38 9.99 60 307806 2155 46376041
Nausea 38.98 9.99 3956 303910 683498 45694698
Neoplasm progression 38.75 9.99 73 307793 26610 46351586
Knee arthroplasty 38.72 9.99 60 307806 23605 46354591
Blood lactate dehydrogenase increased 38.54 9.99 47 307819 20453 46357743
Sneezing 38.17 9.99 176 307690 12565 46365631
Drug eruption 37.93 9.99 51 307815 21278 46356918
Sinus congestion 37.75 9.99 179 307687 12930 46365266
Injury 37.57 9.99 450 307416 43577 46334619
Product taste abnormal 37.51 9.99 55 307811 1908 46376288
Fluid retention 37.31 9.99 507 307359 50539 46327657
Conjunctivitis allergic 37.24 9.99 34 307832 697 46377499
Lung neoplasm malignant 37.22 9.99 201 307665 15288 46362908
Gamma-glutamyltransferase increased 36.96 9.99 98 307768 31642 46346554
Drug resistance 36.88 9.99 36 307830 17332 46360864
Pulmonary mass 36.54 9.99 222 307644 17635 46360561
Wound 36.20 9.99 152 307714 42650 46335546
Allergy to animal 35.98 9.99 31 307835 587 46377609
Stress cardiomyopathy 35.83 9.99 123 307743 7661 46370535
Haemophagocytic lymphohistiocytosis 35.72 9.99 6 307860 8336 46369860
Emotional distress 35.67 9.99 334 307532 30373 46347823
Pharyngeal swelling 35.55 9.99 73 307793 3330 46374866
Poisoning deliberate 35.54 9.99 5 307861 7921 46370275
Renal failure 35.45 9.99 531 307335 113063 46265133
Myelodysplastic syndrome 35.21 9.99 31 307835 15680 46362516
Neuropathy peripheral 34.90 9.99 407 307459 90486 46287710
Bronchial hyperreactivity 34.86 9.99 45 307821 1381 46376815
Transplant rejection 34.84 9.99 10 307856 9586 46368610
Cardiac failure 34.70 9.99 348 307518 79600 46298596
Product complaint 34.67 9.99 165 307701 11936 46366260
Hip arthroplasty 34.61 9.99 41 307825 18071 46360125
Device expulsion 34.43 9.99 82 307784 27460 46350736
Cerebral haemorrhage 34.26 9.99 86 307780 28285 46349911
Septic shock 34.25 9.99 232 307634 57661 46320535
Rhinitis 33.87 9.99 122 307744 7784 46370412
Asthma-chronic obstructive pulmonary disease overlap syndrome 33.60 9.99 27 307839 462 46377734
Herpes zoster 33.53 9.99 286 307580 67586 46310610
Chronic respiratory failure 33.52 9.99 49 307817 1695 46376501
Psoriasis 33.36 9.99 344 307522 78260 46299936
Cardiotoxicity 33.25 9.99 3 307863 6719 46371477
Respiratory tract inflammation 33.14 9.99 26 307840 429 46377767
Incorrect dose administered 33.12 9.99 452 307414 45098 46333098
Metastases to bone 32.93 9.99 40 307826 17436 46360760
Muscle spasticity 32.79 9.99 156 307710 11284 46366912
Nasal discharge discolouration 32.77 9.99 44 307822 1404 46376792
Lung diffusion test decreased 32.74 9.99 30 307836 618 46377578
Night sweats 31.95 9.99 297 307569 26953 46351243
Blood test abnormal 31.92 9.99 136 307730 9384 46368812
Injection site erythema 31.88 9.99 325 307541 74102 46304094
Aphonia 31.85 9.99 120 307746 7825 46370371
Febrile bone marrow aplasia 31.55 9.99 4 307862 6858 46371338
Shock 31.52 9.99 60 307806 21785 46356411
Breast cancer 31.31 9.99 174 307692 45344 46332852
Interstitial lung disease 31.02 9.99 218 307648 53731 46324465
Mite allergy 30.54 9.99 24 307842 397 46377799
Type 2 diabetes mellitus 30.43 9.99 230 307636 19645 46358551
Loss of personal independence in daily activities 30.33 9.99 538 307328 56645 46321551
Pulmonary congestion 30.29 9.99 184 307682 14615 46363581
Akathisia 29.99 9.99 7 307859 7707 46370489
Progressive multifocal leukoencephalopathy 29.78 9.99 19 307847 11327 46366869
Status epilepticus 29.65 9.99 29 307837 13950 46364246
Forced expiratory volume abnormal 29.46 9.99 15 307851 109 46378087
Hepatic failure 29.31 9.99 117 307749 33299 46344897
Paraesthesia oral 29.12 9.99 154 307712 11619 46366577
Illness 28.95 9.99 158 307708 12066 46366130
Peritonitis 28.92 9.99 58 307808 20656 46357540
Lymphopenia 28.82 9.99 35 307831 15258 46362938
Acute myeloid leukaemia 28.80 9.99 37 307829 15741 46362455
Forced expiratory flow decreased 28.78 9.99 12 307854 51 46378145
Inflammation 28.60 9.99 196 307670 48585 46329611
Ascites 28.48 9.99 134 307732 36450 46341746
Psoriatic arthropathy 28.46 9.99 133 307733 36246 46341950
Seizure 28.31 9.99 607 307259 122447 46255749
Pulmonary embolism 28.22 9.99 926 306940 107659 46270537
Breath alcohol test positive 28.20 9.99 7 307859 0 46378196
Rash maculo-papular 28.15 9.99 92 307774 27782 46350414
Paranasal sinus discomfort 28.14 9.99 57 307809 2575 46375621
Osteonecrosis 28.11 9.99 82 307784 25662 46352534
Myelosuppression 28.01 9.99 8 307858 7695 46370501
Blood creatinine increased 27.84 9.99 346 307520 76057 46302139
Helicobacter infection 27.72 9.99 22 307844 11714 46366482
Liver injury 27.71 9.99 39 307827 15962 46362234
Immunodeficiency 27.49 9.99 164 307702 12942 46365254
Polyneuropathy 27.29 9.99 22 307844 11622 46366574
Red blood cell sedimentation rate increased 27.16 9.99 70 307796 22819 46355377
Epilepsy 27.11 9.99 74 307792 23664 46354532
Toxic skin eruption 27.09 9.99 25 307841 12362 46365834
Extrapyramidal disorder 26.77 9.99 21 307845 11247 46366949
Pulmonary pain 26.47 9.99 43 307823 1633 46376563
Cystic fibrosis respiratory infection suppression 26.33 9.99 23 307843 444 46377752
Product use issue 26.33 9.99 452 307414 94192 46284004
Gait disturbance 25.97 9.99 744 307122 144519 46233677
Bronchial disorder 25.83 9.99 33 307833 1002 46377194
Hypertensive crisis 25.82 9.99 31 307835 13584 46364612
Pruritus 25.81 9.99 1893 305973 240459 46137737
Bradycardia 25.78 9.99 296 307570 66002 46312194
Exercise tolerance decreased 25.30 9.99 77 307789 4500 46373696
Nasal mucosal disorder 25.30 9.99 21 307845 377 46377819
Spirometry abnormal 25.25 9.99 16 307850 184 46378012
Proteinuria 25.19 9.99 44 307822 16509 46361687
Vocal cord disorder 25.14 9.99 36 307830 1222 46376974
Rash 24.96 9.99 2018 305848 354494 46023702
Bronchitis bacterial 24.93 9.99 27 307839 685 46377511
Fracture 24.86 9.99 44 307822 16427 46361769
Rhinovirus infection 24.81 9.99 66 307800 3570 46374626
Inappropriate antidiuretic hormone secretion 24.79 9.99 34 307832 14068 46364128
Thrombotic microangiopathy 24.56 9.99 12 307854 8294 46369902
Infusion site swelling 24.46 9.99 88 307778 5611 46372585
Acute hepatic failure 24.39 9.99 37 307829 14684 46363512
Eye pruritus 24.39 9.99 148 307718 11750 46366446
Hereditary angioedema 24.38 9.99 86 307780 5430 46372766
Product use in unapproved indication 24.19 9.99 434 307432 89839 46288357
Cardiac arrest 24.10 9.99 435 307431 89964 46288232
Transaminases increased 23.84 9.99 98 307768 27663 46350533
Lung opacity 23.83 9.99 34 307832 1150 46377046
Eczema 23.74 9.99 222 307644 20178 46358018
Dehydration 23.73 9.99 837 307029 158703 46219493
Graft versus host disease 23.67 9.99 7 307859 6581 46371615
Sinus pain 23.64 9.99 44 307822 1866 46376330
Foot deformity 23.47 9.99 41 307825 15384 46362812
Swelling face 23.29 9.99 485 307381 52574 46325622
Frustration tolerance decreased 23.27 9.99 82 307784 5175 46373021
Generalised tonic-clonic seizure 23.13 9.99 96 307770 27026 46351170
Respiratory tract infection viral 22.86 9.99 43 307823 1838 46376358
Respiratory arrest 22.86 9.99 130 307736 33686 46344510
Rhabdomyolysis 22.82 9.99 172 307694 41737 46336459
Burning sensation 22.55 9.99 415 307451 43996 46334200
Creatinine renal clearance decreased 22.54 9.99 98 307768 6822 46371374
Polycystic ovaries 22.53 9.99 36 307830 1348 46376848
Disorientation 22.31 9.99 147 307719 36771 46341425
Plasma cell myeloma 22.15 9.99 187 307679 44291 46333905
Sputum retention 22.15 9.99 20 307846 404 46377792
Tuberculosis 22.12 9.99 21 307845 10244 46367952
Muscle rigidity 21.91 9.99 20 307846 9941 46368255
Embolism venous 21.87 9.99 50 307816 2457 46375739
Encephalopathy 21.71 9.99 131 307735 33458 46344738
Respiratory tract irritation 21.67 9.99 20 307846 416 46377780
Painful respiration 21.47 9.99 50 307816 2487 46375709
Gallbladder injury 21.36 9.99 35 307831 1339 46376857
Pharyngeal oedema 21.34 9.99 166 307700 14305 46363891
Choking sensation 21.31 9.99 59 307807 3268 46374928
Distal intestinal obstruction syndrome 21.28 9.99 19 307847 378 46377818
Hypercapnia 21.21 9.99 73 307793 4553 46373643
Rheumatoid nodule 21.19 9.99 17 307849 9003 46369193
Hypotension 21.11 9.99 1287 306579 231302 46146894
Nasal inflammation 21.05 9.99 20 307846 432 46377764
Product delivery mechanism issue 20.86 9.99 17 307849 297 46377899
Premature delivery 20.82 9.99 75 307791 21994 46356202
Haemoglobin decreased 20.69 9.99 670 307196 128279 46249917
Throat clearing 20.51 9.99 19 307847 397 46377799
Sinusitis fungal 20.36 9.99 27 307839 851 46377345
Peripheral sensory neuropathy 20.36 9.99 9 307857 6594 46371602
Breast cancer metastatic 20.23 9.99 37 307829 13641 46364555
Aplastic anaemia 20.16 9.99 11 307855 7142 46371054
Unintentional medical device removal 20.12 9.99 3 307863 4550 46373646
Diffuse large B-cell lymphoma 20.11 9.99 7 307859 5931 46372265
Nasal turbinate hypertrophy 20.02 9.99 19 307847 410 46377786
Sleep disorder due to general medical condition, insomnia type 19.94 9.99 5 307861 5244 46372952
Sinus operation 19.89 9.99 35 307831 1420 46376776
Intentional device misuse 19.79 9.99 26 307840 812 46377384
Abortion spontaneous 19.77 9.99 188 307678 43458 46334738
Asthma exercise induced 19.70 9.99 12 307854 128 46378068
Oxygen consumption increased 19.67 9.99 61 307805 3602 46374594
Therapy non-responder 19.61 9.99 175 307691 40977 46337219
Feeling abnormal 19.47 9.99 1010 306856 124050 46254146
Uveitis 19.42 9.99 17 307849 8624 46369572
Eosinophilia 19.39 9.99 203 307663 19014 46359182
Shock haemorrhagic 19.34 9.99 17 307849 8607 46369589
Hypoalbuminaemia 19.27 9.99 23 307843 10104 46368092
Osteomyelitis 19.23 9.99 79 307787 22304 46355892
Blood bilirubin increased 19.23 9.99 139 307727 34045 46344151
Hepatitis cholestatic 19.21 9.99 10 307856 6667 46371529
Nasal pruritus 19.19 9.99 16 307850 289 46377907
Ischaemic stroke 19.19 9.99 52 307814 16670 46361526
Hyper IgE syndrome 19.02 9.99 14 307852 209 46377987
Exposure during pregnancy 18.89 9.99 556 307310 107656 46270540
Crepitations 18.88 9.99 85 307781 6007 46372189
Panniculitis 18.85 9.99 7 307859 5697 46372499
Duodenal ulcer perforation 18.78 9.99 17 307849 8485 46369711
Body temperature decreased 18.77 9.99 152 307714 13257 46364939
Psychotic disorder 18.72 9.99 81 307785 22540 46355656
Lip discolouration 18.70 9.99 20 307846 500 46377696
Hypocalcaemia 18.63 9.99 102 307764 26683 46351513
Swelling 18.56 9.99 653 307213 123858 46254338
Tubulointerstitial nephritis 18.51 9.99 44 307822 14744 46363452
Mouth swelling 18.50 9.99 60 307806 3629 46374567
Carbon dioxide increased 18.38 9.99 30 307836 1144 46377052
Dermatitis allergic 18.27 9.99 144 307722 12459 46365737
Infusion site erythema 18.25 9.99 99 307767 7543 46370653
Stress urinary incontinence 18.24 9.99 42 307824 2074 46376122
Exposure to allergen 18.16 9.99 12 307854 149 46378047
Haemolytic anaemia 18.05 9.99 23 307843 9819 46368377
Back pain 18.04 9.99 1614 306252 208425 46169771
Tremor 18.02 9.99 934 306932 114705 46263491
Drug level increased 17.85 9.99 62 307804 18379 46359817
Expired product administered 17.84 9.99 79 307787 5543 46372653
Ulcer 17.84 9.99 57 307809 17335 46360861
Tobacco abuse 17.79 9.99 22 307844 646 46377550
Hyperkalaemia 17.60 9.99 232 307634 50477 46327719
Broncholithiasis 17.57 9.99 10 307856 93 46378103
Pathogen resistance 17.55 9.99 9 307857 6051 46372145
Pneumonia aspiration 17.54 9.99 129 307737 31476 46346720
Nasal oedema 17.49 9.99 25 307841 847 46377349
Electrocardiogram QRS complex prolonged 17.48 9.99 7 307859 5442 46372754
Respiratory gas exchange disorder 17.46 9.99 17 307849 379 46377817
Haemorrhage intracranial 17.45 9.99 36 307830 12688 46365508
Brain oedema 17.37 9.99 35 307831 12443 46365753
Magnetic resonance imaging thoracic abnormal 17.31 9.99 7 307859 27 46378169
Rubber sensitivity 17.27 9.99 36 307830 1660 46376536
Haematoma 17.26 9.99 131 307735 31741 46346455
Cervix neoplasm 17.22 9.99 13 307853 202 46377994
Injection site bruising 17.22 9.99 151 307715 35485 46342711
C-reactive protein abnormal 17.09 9.99 77 307789 21193 46357003
Angioedema 17.06 9.99 359 307507 38983 46339213
Sensitisation 17.04 9.99 22 307844 675 46377521
Blood parathyroid hormone decreased 16.98 9.99 4 307862 4377 46373819
Bradyphrenia 16.96 9.99 10 307856 6220 46371976
PCO2 increased 16.93 9.99 30 307836 1224 46376972
Metastases to central nervous system 16.92 9.99 30 307836 11191 46367005
Leukoencephalopathy 16.88 9.99 3 307863 4001 46374195
Foreign body aspiration 16.83 9.99 12 307854 170 46378026
Enthesopathy 16.82 9.99 5 307861 4685 46373511
Central obesity 16.79 9.99 24 307842 813 46377383
Bronchitis chronic 16.75 9.99 63 307803 4104 46374092
Metastases to lung 16.67 9.99 28 307838 10668 46367528
Foreign body in reproductive tract 16.65 9.99 14 307852 256 46377940
Prescribed underdose 16.61 9.99 34 307832 12019 46366177
Respiratory depression 16.61 9.99 32 307834 11568 46366628
Multiple allergies 16.61 9.99 94 307772 7277 46370919
Idiopathic intracranial hypertension 16.57 9.99 45 307821 2464 46375732
Adverse drug reaction 16.50 9.99 200 307666 44162 46334034
Bacterial tracheitis 16.48 9.99 6 307860 16 46378180
Colitis 16.43 9.99 162 307704 37185 46341011
Sinus headache 16.43 9.99 68 307798 4632 46373564
Erysipelas 16.40 9.99 13 307853 6925 46371271
Musculoskeletal pain 16.39 9.99 345 307521 69783 46308413
Atopy 16.31 9.99 12 307854 179 46378017
Product prescribing issue 16.22 9.99 25 307841 907 46377289
Duodenal ulcer repair 16.08 9.99 8 307858 55 46378141
Salpingo-oophorectomy unilateral 16.03 9.99 16 307850 368 46377828
Multiple sclerosis relapse 16.02 9.99 189 307677 41936 46336260
Dyspnoea at rest 15.91 9.99 56 307810 3532 46374664
Nasal obstruction 15.91 9.99 21 307845 659 46377537
Vocal cord dysfunction 15.87 9.99 12 307854 187 46378009
Immune reconstitution inflammatory syndrome 15.85 9.99 9 307857 5716 46372480
Biliary dyskinesia 15.66 9.99 47 307819 2726 46375470
Respiratory acidosis 15.61 9.99 81 307785 6067 46372129
Device ineffective 15.42 9.99 11 307855 156 46378040
Increased viscosity of bronchial secretion 15.41 9.99 14 307852 285 46377911
Jaundice 15.41 9.99 119 307747 28726 46349470
Weight increased 15.39 9.99 1272 306594 163201 46214995
Accidental exposure to product 15.38 9.99 79 307787 21002 46357194
Lung operation 15.20 9.99 12 307854 200 46377996
Pneumonia pseudomonal 15.16 9.99 39 307827 2067 46376129
Administration site erythema 15.13 9.99 19 307847 567 46377629
Oxygen therapy 15.07 9.99 36 307830 1821 46376375
Therapy partial responder 15.05 9.99 6 307860 4676 46373520
Ejection fraction decreased 14.98 9.99 64 307802 17873 46360323
Delirium 14.95 9.99 165 307701 37063 46341133
Occupational asthma 14.95 9.99 10 307856 127 46378069
Blood electrolytes abnormal 14.93 9.99 25 307841 974 46377222
Oral candidiasis 14.87 9.99 179 307687 17353 46360843
Thyroid atrophy 14.87 9.99 6 307860 23 46378173
Rash erythematous 14.75 9.99 313 307553 34037 46344159
Rheumatoid factor positive 14.74 9.99 77 307789 20384 46357812
Impaired work ability 14.72 9.99 39 307827 12597 46365599
Hiatus hernia 14.72 9.99 185 307681 18117 46360079
Pharyngitis streptococcal 14.70 9.99 101 307765 8367 46369829
Pyrexia 14.69 9.99 2046 305820 346756 46031440
Pickwickian syndrome 14.68 9.99 14 307852 304 46377892
Tachypnoea 14.67 9.99 152 307714 14199 46363997
Hyponatraemia 14.52 9.99 534 307332 100798 46277398
Fluid overload 14.49 9.99 256 307610 26929 46351267
Rectal prolapse 14.46 9.99 32 307834 1538 46376658
Dizziness 14.42 9.99 2503 305363 337911 46040285
Cerebrovascular accident 14.35 9.99 533 307333 100506 46277690
Enteritis 14.34 9.99 14 307852 6741 46371455
Breast cancer recurrent 14.34 9.99 4 307862 3907 46374289
Blood pressure increased 14.25 9.99 994 306872 125672 46252524
Folliculitis 14.19 9.99 12 307854 6191 46372005
Intentional product misuse 14.11 9.99 222 307644 46906 46331290
Use of accessory respiratory muscles 14.10 9.99 11 307855 180 46378016
Peritonitis bacterial 14.10 9.99 22 307844 8631 46369565
Sepsis 14.08 9.99 743 307123 135271 46242925
Bursitis 14.06 9.99 196 307670 19646 46358550
Enterocolitis 14.03 9.99 12 307854 6156 46372040
Essential hypertension 14.01 9.99 61 307805 4249 46373947
Cor pulmonale 14.00 9.99 36 307830 1907 46376289
PO2 decreased 14.00 9.99 31 307835 1491 46376705
Cytomegalovirus viraemia 13.97 9.99 6 307860 4472 46373724
Mucosal discolouration 13.96 9.99 16 307850 433 46377763
Polyp 13.92 9.99 69 307797 5074 46373122
Mycobacterial disease carrier 13.89 9.99 4 307862 3 46378193
Carbon dioxide abnormal 13.89 9.99 10 307856 144 46378052
Purpura 13.80 9.99 28 307838 9930 46368266
Ear discomfort 13.80 9.99 84 307782 6677 46371519
Metastases to lymph nodes 13.78 9.99 14 307852 6617 46371579
Migraine 13.78 9.99 579 307287 69447 46308749
Tongue pruritus 13.73 9.99 16 307850 441 46377755
Pulmonary hypertension 13.58 9.99 322 307544 35671 46342525
Bronchial neoplasm 13.51 9.99 12 307854 237 46377959
Neuromyotonia 13.51 9.99 7 307859 53 46378143
Stevens-Johnson syndrome 13.46 9.99 94 307772 23203 46354993
Varicella zoster gastritis 13.46 9.99 6 307860 31 46378165
Limb injury 13.42 9.99 189 307677 18985 46359211
Nocturnal dyspnoea 13.41 9.99 24 307842 987 46377209
Uterine perforation 13.41 9.99 88 307778 7179 46371017
Diastolic hypotension 13.40 9.99 8 307858 82 46378114
Caesarean section 13.40 9.99 60 307806 16543 46361653
Functional residual capacity increased 13.40 9.99 8 307858 82 46378114
Vertigo 13.38 9.99 252 307614 51796 46326400
Suspected suicide 13.38 9.99 7 307859 4654 46373542
Red cell distribution width abnormal 13.38 9.99 10 307856 153 46378043
Epstein-Barr virus infection 13.35 9.99 15 307851 6769 46371427
Therapeutic response decreased 13.34 9.99 202 307664 42943 46335253
Nasal mucosal discolouration 13.31 9.99 5 307861 15 46378181
Pulmonary thrombosis 13.27 9.99 89 307777 7313 46370883
Peak expiratory flow rate abnormal 13.27 9.99 9 307857 117 46378079
Arthritis bacterial 13.24 9.99 11 307855 5725 46372471
Neuroleptic malignant syndrome 13.21 9.99 34 307832 11088 46367108
Retching 13.20 9.99 138 307728 12919 46365277
Blood creatine phosphokinase increased 13.17 9.99 118 307748 27606 46350590
Laryngeal pain 13.14 9.99 63 307803 4571 46373625
Neurosensory hypoacusis 13.13 9.99 13 307853 296 46377900
Blood alkaline phosphatase increased 13.10 9.99 183 307683 39426 46338770
Nystagmus 13.07 9.99 11 307855 5688 46372508
Subdural haematoma 13.05 9.99 43 307823 12954 46365242
Pemphigoid 13.03 9.99 11 307855 5680 46372516
Increased viscosity of upper respiratory secretion 13.00 9.99 8 307858 87 46378109
Self-injurious ideation 13.00 9.99 39 307827 2261 46375935
Infusion site urticaria 12.99 9.99 20 307846 725 46377471
Skin necrosis 12.97 9.99 23 307843 8581 46369615
Depressed level of consciousness 12.96 9.99 228 307638 47341 46330855
Device defective 12.94 9.99 24 307842 1015 46377181
Wrong technique in product usage process 12.93 9.99 267 307599 54155 46324041
Enterovirus infection 12.90 9.99 18 307848 596 46377600
Parainfluenzae virus infection 12.80 9.99 33 307833 1751 46376445
Angle closure glaucoma 12.79 9.99 37 307829 2102 46376094
Nervousness 12.73 9.99 261 307605 28214 46349982
Cystic fibrosis lung 12.71 9.99 9 307857 126 46378070
Paranoia 12.67 9.99 116 307750 10481 46367715
Hypercalcaemia 12.61 9.99 84 307782 20962 46357234
Respiratory syncytial virus bronchiolitis 12.58 9.99 13 307853 312 46377884
Poor quality product administered 12.52 9.99 46 307820 2963 46375233
Lymph node calcification 12.50 9.99 10 307856 170 46378026
Decreased bronchial secretion 12.49 9.99 7 307859 63 46378133
Aplasia 12.49 9.99 4 307862 3572 46374624
Nasal turbinate abnormality 12.47 9.99 6 307860 38 46378158
Malignant melanoma 12.37 9.99 31 307835 10203 46367993
Urinary tract infection 12.31 9.99 1268 306598 218998 46159198
Aphthous ulcer 12.28 9.99 28 307838 9520 46368676
Pregnancy 12.24 9.99 117 307749 27020 46351176
Hyperammonaemia 12.24 9.99 8 307858 4708 46373488
Forced expiratory volume increased 12.23 9.99 5 307861 20 46378176
Product label issue 12.22 9.99 18 307848 627 46377569
Aplasia pure red cell 12.19 9.99 7 307859 4418 46373778
Pneumococcal infection 12.18 9.99 14 307852 380 46377816
Tumour lysis syndrome 12.17 9.99 18 307848 7218 46370978
Kidney transplant rejection 12.10 9.99 6 307860 4112 46374084
Dyskinesia 12.09 9.99 127 307739 28798 46349398
Oesophageal dilatation 12.09 9.99 13 307853 327 46377869
Airway remodelling 12.09 9.99 6 307860 41 46378155
Pulmonary amyloidosis 12.08 9.99 3 307863 0 46378196
Blood iron abnormal 12.08 9.99 3 307863 3167 46375029
Product adhesion issue 12.07 9.99 9 307857 4946 46373250
Lung consolidation 12.01 9.99 53 307813 3714 46374482
Cytokine release syndrome 11.98 9.99 14 307852 6209 46371987
Mydriasis 11.97 9.99 33 307833 10520 46367676
Bronchomalacia 11.97 9.99 9 307857 139 46378057
Orthopnoea 11.96 9.99 73 307793 5807 46372389
Bronchial haemorrhage 11.93 9.99 13 307853 332 46377864
Mixed liver injury 11.93 9.99 3 307863 3140 46375056
Nasal flaring 11.85 9.99 5 307861 22 46378174
Oliguria 11.83 9.99 25 307841 8734 46369462
Respiratory syncytial virus infection 11.79 9.99 63 307803 4772 46373424
Nightmare 11.77 9.99 164 307702 16434 46361762
Cardiac murmur 11.75 9.99 121 307745 11283 46366913
Airway peak pressure increased 11.75 9.99 12 307854 284 46377912
Injection site swelling 11.73 9.99 191 307675 40136 46338060
Functional residual capacity decreased 11.71 9.99 7 307859 72 46378124
Ileus paralytic 11.68 9.99 7 307859 4316 46373880
Gastroenteritis viral 11.65 9.99 176 307690 17943 46360253
Crying 11.60 9.99 200 307666 20941 46357255
Pulmonary oedema 11.56 9.99 429 307437 50676 46327520
Administration site pain 11.56 9.99 18 307848 659 46377537
Premature baby 11.51 9.99 71 307795 18041 46360155
Pneumonectomy 11.46 9.99 4 307862 9 46378187
Drug tolerance decreased 11.46 9.99 3 307863 3056 46375140
Loss of consciousness 11.44 9.99 590 307276 107648 46270548
Gingivitis 11.43 9.99 20 307846 7500 46370696
Stridor 11.37 9.99 46 307820 3101 46375095
Sputum abnormal 11.36 9.99 13 307853 351 46377845
Joint stiffness 11.34 9.99 119 307747 26989 46351207
Influenza B virus test positive 11.30 9.99 13 307853 353 46377843
Liver disorder 11.30 9.99 175 307691 37071 46341125
Pharyngeal erythema 11.28 9.99 29 307837 1536 46376660
Skin toxicity 11.23 9.99 5 307861 3649 46374547
Sinus tachycardia 11.23 9.99 203 307663 21446 46356750
Vomiting 11.22 9.99 2732 305134 450062 45928134
Live birth 11.21 9.99 33 307833 10297 46367899
Atypical fracture 11.20 9.99 16 307850 542 46377654
Activated partial thromboplastin time 11.17 9.99 4 307862 10 46378186
Dry eye 11.16 9.99 137 307729 30185 46348011
Oral pruritus 11.14 9.99 28 307838 1463 46376733
Body temperature abnormal 11.12 9.99 24 307842 1134 46377062
Eosinophilic oesophagitis 11.11 9.99 10 307856 201 46377995
Nasal disorder 11.09 9.99 36 307830 2178 46376018
Tobacco user 11.08 9.99 19 307847 755 46377441
Oxygen consumption decreased 11.07 9.99 10 307856 202 46377994
Femoral neck fracture 11.05 9.99 23 307843 8080 46370116
Pulmonary tuberculosis 11.01 9.99 9 307857 4722 46373474
Nasal cyst 11.00 9.99 6 307860 51 46378145
Bronchoscopy 11.00 9.99 6 307860 51 46378145
Pre-existing condition improved 10.97 9.99 78 307788 6534 46371662
Laboratory test abnormal 10.96 9.99 97 307769 22750 46355446
Sleep terror 10.90 9.99 19 307847 765 46377431
Peptic ulcer perforation 10.87 9.99 9 307857 161 46378035
Bursitis infective 10.86 9.99 24 307842 1153 46377043
Hyperbilirubinaemia 10.85 9.99 34 307832 10404 46367792
Overweight 10.85 9.99 45 307821 3068 46375128
Cardiac failure congestive 10.84 9.99 723 307143 91027 46287169
Pulmonary toxicity 10.83 9.99 9 307857 4684 46373512
Intentional product use issue 10.82 9.99 265 307601 52515 46325681
Peripheral vascular disorder 10.80 9.99 72 307794 5905 46372291
Breath sounds 10.78 9.99 8 307858 121 46378075
Anosmia 10.74 9.99 53 307813 3891 46374305
Inspiratory capacity decreased 10.73 9.99 7 307859 85 46378111
Fall 10.70 9.99 1959 305907 327138 46051058
Heart block congenital 10.65 9.99 4 307862 12 46378184
Eosinophilia myalgia syndrome 10.65 9.99 4 307862 12 46378184
Psychomotor retardation 10.63 9.99 4 307862 3229 46374967
Drug ineffective for unapproved indication 10.61 9.99 64 307802 16349 46361847
Acute respiratory distress syndrome 10.54 9.99 93 307773 21829 46356367
Coagulopathy 10.51 9.99 75 307791 18424 46359772
Parkinsonism 10.47 9.99 23 307843 7925 46370271
Sarcoidosis 10.47 9.99 64 307802 5095 46373101
Subarachnoid haemorrhage 10.46 9.99 38 307828 11115 46367081
Spinal pain 10.44 9.99 32 307834 9860 46368336
Blood calcium decreased 10.38 9.99 153 307713 15520 46362676
Colitis microscopic 10.37 9.99 17 307849 6539 46371657
Trifascicular block 10.35 9.99 8 307858 129 46378067
Oropharyngitis fungal 10.35 9.99 6 307860 58 46378138
Injection site pruritus 10.35 9.99 192 307674 39551 46338645
Drug administered in wrong device 10.34 9.99 5 307861 32 46378164
Candida infection 10.32 9.99 205 307661 22035 46356161
Device failure 10.30 9.99 71 307795 5888 46372308
Nephropathy toxic 10.30 9.99 21 307845 7433 46370763
Tooth disorder 10.29 9.99 101 307765 23202 46354994
BK virus infection 10.28 9.99 3 307863 2846 46375350
Haemolysis 10.26 9.99 15 307851 6044 46372152
Cerebellar syndrome 10.25 9.99 5 307861 3460 46374736
Rheumatic fever 10.25 9.99 3 307863 2840 46375356
Enterococcal infection 10.25 9.99 19 307847 6968 46371228
Aspirin-exacerbated respiratory disease 10.23 9.99 18 307848 730 46377466
Pneumonia respiratory syncytial viral 10.20 9.99 17 307849 660 46377536
Hyperventilation 10.19 9.99 68 307798 5579 46372617
Upper airway obstruction 10.13 9.99 15 307851 525 46377671
Dependence on oxygen therapy 10.12 9.99 12 307854 337 46377859
Red blood cell agglutination 10.03 9.99 3 307863 3 46378193
Tympanoplasty 10.03 9.99 3 307863 3 46378193
Blood pressure ambulatory abnormal 10.03 9.99 3 307863 3 46378193
Administration site inflammation 10.03 9.99 3 307863 3 46378193
Jaundice cholestatic 10.03 9.99 11 307855 5018 46373178
Noninfective bronchitis 10.03 9.99 3 307863 3 46378193
Colitis ulcerative 10.02 9.99 72 307794 17660 46360536

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 3707.90 10.43 2374 163664 33800 29752640
Wheezing 1598.70 10.43 1344 164694 29594 29756846
Dyspnoea 1395.02 10.43 4522 161516 328773 29457667
Chronic obstructive pulmonary disease 1334.97 10.43 1455 164583 44671 29741769
Product quality issue 1110.98 10.43 883 165155 17891 29768549
Poor quality device used 664.72 10.43 235 165803 708 29785732
Obstructive airways disorder 661.13 10.43 483 165555 8576 29777864
Cough 653.85 10.43 1846 164192 123796 29662644
Infective pulmonary exacerbation of cystic fibrosis 532.30 10.43 415 165623 8157 29778283
Blood count abnormal 461.58 10.43 436 165602 11216 29775224
Productive cough 420.35 10.43 662 165376 29291 29757149
Forced expiratory volume decreased 386.71 10.43 235 165803 3015 29783425
Completed suicide 359.15 10.43 60 165978 99432 29687008
Therapeutic product effect incomplete 343.60 10.43 648 165390 33186 29753254
Sputum discoloured 322.08 10.43 279 165759 6389 29780051
Sleep disorder due to a general medical condition 314.92 10.43 158 165880 1349 29785091
Toxicity to various agents 312.61 10.43 313 165725 176870 29609570
Chest discomfort 295.72 10.43 727 165311 44753 29741687
Pneumonia 254.26 10.43 2898 163140 331408 29455032
Drug abuse 216.30 10.43 92 165946 81980 29704460
Lower respiratory tract infection 214.32 10.43 464 165574 26250 29760190
Pulmonary function test decreased 210.03 10.43 181 165857 4114 29782326
Cystic fibrosis 202.51 10.43 137 165901 2137 29784303
Nasal congestion 195.15 10.43 361 165677 18205 29768235
Product dose omission issue 171.34 10.43 978 165060 90653 29695787
Bronchitis 168.88 10.43 539 165499 38586 29747854
No adverse event 168.59 10.43 327 165711 17092 29769348
Bronchospasm 148.41 10.43 231 165807 10107 29776333
Dyspnoea exertional 141.13 10.43 475 165563 34955 29751485
Bronchiectasis 134.51 10.43 155 165883 5049 29781391
Nasal polyps 132.24 10.43 87 165951 1292 29785148
Febrile neutropenia 130.88 10.43 245 165793 106448 29679992
Off label use 129.19 10.43 831 165207 248459 29537981
Hepatic function abnormal 127.63 10.43 37 166001 41908 29744532
Middle insomnia 126.34 10.43 158 165880 5615 29780825
Drug interaction 122.25 10.43 630 165408 198938 29587502
Neutropenia 120.66 10.43 341 165697 128199 29658241
Blood immunoglobulin E increased 118.89 10.43 89 165949 1641 29784799
Influenza 118.55 10.43 516 165522 42882 29743558
Respiratory disorder 117.17 10.43 283 165755 17211 29769229
Device delivery system issue 115.19 10.43 37 166001 74 29786366
Sinusitis 108.90 10.43 419 165619 32926 29753514
Loss of personal independence in daily activities 105.32 10.43 310 165728 21225 29765215
Breath sounds abnormal 103.14 10.43 132 165906 4803 29781637
Pancytopenia 96.79 10.43 204 165834 84848 29701592
Thrombocytopenia 94.73 10.43 414 165624 136630 29649810
Bronchial obstruction 92.78 10.43 72 165966 1404 29785036
Eosinophil count abnormal 88.56 10.43 39 165999 239 29786201
Anaemia 88.04 10.43 734 165304 207258 29579182
Bone marrow failure 85.73 10.43 29 166009 29756 29756684
Oxygen saturation decreased 85.27 10.43 470 165568 42970 29743470
Respiratory tract congestion 83.20 10.43 126 165912 5380 29781060
Cytomegalovirus infection 81.60 10.43 16 166022 23658 29762782
Blood test abnormal 81.46 10.43 125 165913 5400 29781040
Respiratory rate increased 80.98 10.43 163 165875 8752 29777688
Nasopharyngitis 80.76 10.43 581 165457 58268 29728172
Mucosal inflammation 80.57 10.43 34 166004 30460 29755980
Eosinophilic granulomatosis with polyangiitis 80.17 10.43 63 165975 1252 29785188
Malaise 80.07 10.43 1335 164703 165627 29620813
Reversible airways obstruction 78.86 10.43 36 166002 243 29786197
Asthma-chronic obstructive pulmonary disease overlap syndrome 78.62 10.43 48 165990 621 29785819
Leukopenia 77.03 10.43 120 165918 56039 29730401
Interstitial lung disease 75.74 10.43 136 165902 60061 29726379
Hypoxia 74.89 10.43 488 165550 47366 29739074
Renal impairment 72.69 10.43 232 165806 83952 29702488
Intentional overdose 72.12 10.43 74 165964 41407 29745033
Diarrhoea 70.03 10.43 1369 164669 332734 29453706
Haemoptysis 69.75 10.43 349 165689 30729 29755711
Platelet count decreased 69.47 10.43 327 165711 105802 29680638
Vital capacity decreased 68.93 10.43 37 166001 368 29786072
Asthmatic crisis 68.76 10.43 39 165999 436 29786004
Lung hyperinflation 68.13 10.43 48 165990 802 29785638
Emphysema 67.18 10.43 156 165882 9246 29777194
Sputum increased 66.94 10.43 66 165972 1791 29784649
Eosinophil count increased 65.94 10.43 135 165903 7338 29779102
Malignant neoplasm progression 64.68 10.43 196 165842 72091 29714349
Bronchopulmonary aspergillosis allergic 64.67 10.43 33 166005 293 29786147
Respiratory failure 64.38 10.43 846 165192 99796 29686644
Heart rate increased 64.37 10.43 401 165637 38320 29748120
Upper respiratory tract infection 62.69 10.43 310 165728 27166 29759274
Throat irritation 62.36 10.43 143 165895 8405 29778035
Rhinorrhoea 62.27 10.43 254 165784 20500 29765940
White blood cell count decreased 62.04 10.43 247 165791 83700 29702740
Respiratory distress 60.90 10.43 351 165687 32621 29753819
Product container issue 59.95 10.43 44 165994 786 29785654
Dust allergy 59.72 10.43 34 166004 383 29786057
Coma 58.80 10.43 83 165955 40366 29746074
Forced vital capacity decreased 58.21 10.43 42 165996 730 29785710
Secretion discharge 57.91 10.43 87 165951 3688 29782752
Drug resistance 57.25 10.43 20 166018 20113 29766327
Pyrexia 56.79 10.43 1223 164815 293266 29493174
Sleep terror 55.06 10.43 40 165998 703 29785737
Treatment failure 54.67 10.43 67 165971 34612 29751828
Disseminated intravascular coagulation 53.51 10.43 28 166010 22143 29764297
Nasal obstruction 53.48 10.43 38 166000 644 29785796
Throat tightness 53.22 10.43 121 165917 7071 29779369
Respiratory tract infection 53.21 10.43 198 165840 15308 29771132
Pulmonary function test abnormal 52.91 10.43 51 165987 1345 29785095
Upper-airway cough syndrome 52.76 10.43 70 165968 2640 29783800
Multiple organ dysfunction syndrome 52.69 10.43 178 165860 63309 29723131
Inhalation therapy 52.30 10.43 16 166022 25 29786415
Device malfunction 51.95 10.43 129 165909 7982 29778458
Septic shock 51.66 10.43 180 165858 63427 29723013
Hospitalisation 51.53 10.43 421 165617 43898 29742542
Renal failure 51.40 10.43 462 165576 128504 29657936
Acute respiratory failure 50.92 10.43 280 165758 25570 29760870
Sinus pain 50.75 10.43 37 166001 654 29785786
Lower respiratory tract congestion 50.15 10.43 43 165995 970 29785470
Neutrophil count decreased 49.81 10.43 100 165938 42354 29744086
Blood creatinine increased 49.52 10.43 300 165738 91075 29695365
Bronchial wall thickening 49.49 10.43 31 166007 421 29786019
Dyspnoea at rest 48.72 10.43 66 165972 2540 29783900
Pneumocystis jirovecii pneumonia 48.69 10.43 17 166021 17103 29769337
Chronic sinusitis 48.18 10.43 51 165987 1508 29784932
Bronchial hyperreactivity 47.75 10.43 45 165993 1153 29785287
Bronchial disorder 47.72 10.43 40 165998 874 29785566
Product use in unapproved indication 47.65 10.43 228 165810 73465 29712975
Lung disorder 47.45 10.43 318 165720 31151 29755289
Sinus congestion 47.34 10.43 90 165948 4632 29781808
Rhonchi 47.23 10.43 53 165985 1676 29784764
Cerebral infarction 45.89 10.43 47 165991 26326 29760114
Sensitivity to weather change 45.71 10.43 48 165990 1406 29785034
Lung diffusion test decreased 45.66 10.43 33 166005 575 29785865
Body temperature decreased 45.31 10.43 137 165901 9518 29776922
Status asthmaticus 45.21 10.43 26 166012 299 29786141
Neuropathy peripheral 45.00 10.43 219 165819 70256 29716184
Oropharyngeal pain 43.59 10.43 289 165749 28207 29758233
Stomatitis 43.57 10.43 88 165950 37191 29749249
Rheumatoid arthritis 43.41 10.43 103 165935 41094 29745346
Gastrooesophageal reflux disease 43.38 10.43 317 165721 31938 29754502
Lung consolidation 43.15 10.43 89 165949 4863 29781577
Bronchospasm paradoxical 42.21 10.43 16 166022 62 29786378
Bronchiolitis 41.29 10.43 59 165979 2389 29784051
Drug intolerance 41.07 10.43 122 165916 45169 29741271
Peak expiratory flow rate decreased 41.04 10.43 19 166019 133 29786307
Peritonitis 40.83 10.43 35 166003 21340 29765100
Blood lactate dehydrogenase increased 40.25 10.43 33 166005 20568 29765872
Cerebral haemorrhage 39.84 10.43 76 165962 32811 29753629
Rhinitis 39.80 10.43 82 165956 4477 29781963
Hepatotoxicity 39.43 10.43 26 166012 18119 29768321
Acute kidney injury 39.38 10.43 1187 164851 272655 29513785
Hypoventilation 38.53 10.43 64 165974 2959 29783481
Pulmonary mass 38.36 10.43 140 165898 10722 29775718
Increased viscosity of bronchial secretion 37.95 10.43 21 166017 223 29786217
Painful respiration 37.70 10.43 41 165997 1251 29785189
Spirometry abnormal 36.61 10.43 22 166016 276 29786164
Circumstance or information capable of leading to medication error 36.53 10.43 45 165993 1574 29784866
Overdose 36.31 10.43 296 165742 84041 29702399
Rales 36.10 10.43 98 165940 6402 29780038
Anaphylactic reaction 35.92 10.43 272 165766 27710 29758730
Serotonin syndrome 35.78 10.43 28 166010 17863 29768577
Smoke sensitivity 35.07 10.43 18 166020 162 29786278
Rhabdomyolysis 34.29 10.43 209 165829 63371 29723069
Agranulocytosis 33.94 10.43 43 165995 21899 29764541
Osteonecrosis of jaw 33.75 10.43 32 166006 18586 29767854
Infective exacerbation of chronic obstructive airways disease 33.67 10.43 41 165997 1417 29785023
Seasonal allergy 33.01 10.43 78 165960 4675 29781765
Restrictive pulmonary disease 32.71 10.43 35 166003 1048 29785392
Respiratory symptom 32.67 10.43 30 166008 743 29785697
Blood pressure systolic increased 32.02 10.43 167 165871 14943 29771497
Crepitations 32.01 10.43 59 165979 2965 29783475
Progressive multifocal leukoencephalopathy 31.25 10.43 6 166032 9007 29777433
Hormone receptor positive breast cancer 30.81 10.43 10 166028 21 29786419
Stress 30.81 10.43 205 165833 20030 29766410
Product complaint 30.72 10.43 86 165952 5720 29780720
Drug-induced liver injury 30.57 10.43 44 165994 21230 29765210
Hyperthermia 30.54 10.43 9 166029 10090 29776350
Skin discomfort 30.50 10.43 10 166028 22 29786418
Cardiac failure 30.15 10.43 306 165732 83112 29703328
Palmar-plantar erythrodysaesthesia syndrome 30.08 10.43 23 166015 14847 29771593
Poisoning 29.57 10.43 13 166025 11369 29775071
Sputum abnormal 29.55 10.43 22 166016 402 29786038
Thrombotic microangiopathy 29.29 10.43 6 166032 8604 29777836
Disease progression 29.28 10.43 292 165746 79582 29706858
Bronchial secretion retention 29.23 10.43 27 166011 674 29785766
Acute myeloid leukaemia 29.21 10.43 34 166004 17972 29768468
Hepatocellular injury 29.02 10.43 61 165977 25410 29761030
Choking 28.91 10.43 76 165962 4870 29781570
Nasal disorder 28.79 10.43 34 166004 1137 29785303
Tubulointerstitial nephritis 28.79 10.43 34 166004 17857 29768583
Respiratory syncytial virus infection 28.72 10.43 60 165978 3308 29783132
Respiration abnormal 28.54 10.43 52 165986 2590 29783850
C-reactive protein increased 28.38 10.43 134 165904 43339 29743101
Factitious disorder 28.37 10.43 11 166027 46 29786394
Chest pain 28.32 10.43 853 165185 116774 29669666
Gamma-glutamyltransferase increased 28.12 10.43 77 165961 29273 29757167
Breath alcohol test positive 28.11 10.43 8 166030 8 29786432
Peritonitis bacterial 28.01 10.43 14 166024 11364 29775076
Drug reaction with eosinophilia and systemic symptoms 27.85 10.43 74 165964 28414 29758026
Posterior reversible encephalopathy syndrome 27.76 10.43 7 166031 8700 29777740
Allergy to animal 27.54 10.43 15 166023 154 29786286
Wolff-Parkinson-White syndrome 27.53 10.43 16 166022 188 29786252
Haemophagocytic lymphohistiocytosis 27.37 10.43 10 166028 9781 29776659
Plasma cell myeloma 27.15 10.43 179 165859 53283 29733157
Suicide attempt 27.07 10.43 108 165930 36589 29749851
Increased upper airway secretion 26.90 10.43 40 165998 1680 29784760
Sepsis 26.67 10.43 613 165425 145782 29640658
Obstruction 26.66 10.43 35 166003 1306 29785134
Cystic fibrosis respiratory infection suppression 26.61 10.43 20 166018 371 29786069
Transplant rejection 26.42 10.43 9 166029 9197 29777243
Respiratory tract irritation 26.36 10.43 14 166024 136 29786304
Sopor 26.35 10.43 14 166024 10977 29775463
Increased bronchial secretion 26.30 10.43 35 166003 1324 29785116
Liver disorder 26.27 10.43 81 165957 29641 29756799
Death 26.20 10.43 1669 164369 355614 29430826
Tachypnoea 26.19 10.43 157 165881 14795 29771645
Sputum purulent 26.07 10.43 21 166017 433 29786007
Swollen tongue 26.04 10.43 143 165895 13049 29773391
Nightmare 25.95 10.43 134 165904 11942 29774498
Altered state of consciousness 25.95 10.43 44 165994 19875 29766565
Hepatitis 25.92 10.43 53 165985 22303 29764137
Hyperbilirubinaemia 25.38 10.43 34 166004 16908 29769532
Snoring 25.24 10.43 52 165986 2839 29783601
Forced expiratory flow decreased 25.23 10.43 13 166025 118 29786322
Ear infection 25.16 10.43 94 165944 7280 29779160
Neuroleptic malignant syndrome 25.13 10.43 32 166006 16263 29770177
Cardio-respiratory arrest 24.71 10.43 201 165837 57105 29729335
Lymph node calcification 24.64 10.43 15 166023 193 29786247
Hepatic failure 24.60 10.43 101 165937 33942 29752498
Swelling face 24.40 10.43 201 165837 21003 29765437
Graft versus host disease 24.22 10.43 13 166025 10137 29776303
Blood immunoglobulin E decreased 24.21 10.43 10 166028 51 29786389
Sleep apnoea syndrome 24.01 10.43 168 165870 16689 29769751
Viral infection 23.82 10.43 155 165883 15030 29771410
Perfume sensitivity 23.76 10.43 12 166026 104 29786336
Product administered to patient of inappropriate age 23.70 10.43 47 165991 2496 29783944
Hypercapnia 23.63 10.43 60 165978 3764 29782676
Foetal malformation 23.41 10.43 13 166025 139 29786301
Foetal exposure during pregnancy 23.28 10.43 115 165923 36756 29749684
Myelosuppression 23.12 10.43 6 166032 7316 29779124
Conjunctivitis allergic 23.11 10.43 21 166017 513 29785927
Rhinitis allergic 22.89 10.43 50 165988 2844 29783596
Nasal discharge discolouration 22.84 10.43 15 166023 222 29786218
Pulmonary congestion 22.80 10.43 131 165907 12156 29774284
Nasal inflammation 22.73 10.43 15 166023 224 29786216
Synovitis 22.67 10.43 13 166025 9770 29776670
Asthma exercise induced 22.65 10.43 12 166026 116 29786324
Neurodevelopmental disorder 22.49 10.43 13 166025 151 29786289
Herpes zoster 22.16 10.43 88 165950 29855 29756585
Suffocation feeling 22.16 10.43 21 166017 542 29785898
Ascites 22.13 10.43 113 165925 35808 29750632
Depressed level of consciousness 22.01 10.43 123 165915 38099 29748341
Nasal oedema 21.97 10.43 17 166021 330 29786110
Atelectasis 21.92 10.43 159 165879 15979 29770461
Polyneuropathy 21.81 10.43 20 166018 11803 29774637
Encephalopathy 21.77 10.43 98 165940 32107 29754333
Vocal cord dysfunction 21.71 10.43 13 166025 162 29786278
Brain oedema 21.67 10.43 22 166016 12376 29774064
Chronic respiratory failure 21.50 10.43 30 166008 1188 29785252
Neurotoxicity 21.27 10.43 25 166013 13157 29773283
Pathogen resistance 21.23 10.43 10 166028 8400 29778040
Pickwickian syndrome 20.80 10.43 10 166028 77 29786363
Carbon dioxide increased 20.76 10.43 27 166011 998 29785442
Colitis 20.70 10.43 94 165944 30726 29755714
Blood cholesterol 20.70 10.43 11 166027 107 29786333
Coronary artery disease 20.69 10.43 176 165862 49536 29736904
Rhinovirus infection 20.64 10.43 48 165990 2847 29783593
Cytopenia 20.56 10.43 10 166028 8246 29778194
Decreased activity 20.52 10.43 55 165983 3566 29782874
Alanine aminotransferase increased 20.49 10.43 289 165749 73987 29712453
Product taste abnormal 20.43 10.43 28 166010 1090 29785350
Toxic epidermal necrolysis 20.41 10.43 43 165995 17897 29768543
Total lung capacity abnormal 20.35 10.43 13 166025 183 29786257
Eye swelling 20.34 10.43 101 165937 8863 29777577
Shock haemorrhagic 20.29 10.43 15 166023 9850 29776590
Epstein-Barr virus infection 20.23 10.43 6 166032 6700 29779740
Pancreatitis 20.17 10.43 119 165919 36371 29750069
Pharyngeal oedema 20.04 10.43 80 165958 6391 29780049
Blood bilirubin increased 19.97 10.43 120 165918 36516 29749924
Tracheal disorder 19.94 10.43 11 166027 116 29786324
Lip swelling 19.94 10.43 130 165908 12614 29773826
Lung neoplasm malignant 19.93 10.43 148 165890 14984 29771456
Total lung capacity decreased 19.89 10.43 21 166017 619 29785821
Viral upper respiratory tract infection 19.75 10.43 45 165993 2633 29783807
Eosinophil count 19.70 10.43 11 166027 119 29786321
Myoclonus 19.65 10.43 27 166011 13285 29773155
Myocardial infarction 19.63 10.43 538 165500 125087 29661353
Nephropathy toxic 19.62 10.43 18 166020 10621 29775819
Right atrial enlargement 19.57 10.43 14 166024 240 29786200
Lung opacity 19.27 10.43 24 166014 849 29785591
Lymphocyte count abnormal 19.26 10.43 20 166018 578 29785862
Drug level increased 19.24 10.43 46 165992 18308 29768132
Aspartate aminotransferase increased 19.23 10.43 242 165796 63180 29723260
Bronchial irritation 18.91 10.43 7 166031 25 29786415
Kidney transplant rejection 18.85 10.43 9 166029 7500 29778940
Psoriasis 18.83 10.43 148 165890 42358 29744082
Diffuse large B-cell lymphoma 18.78 10.43 10 166028 7831 29778609
Dermatitis atopic 18.47 10.43 26 166012 1038 29785402
Mite allergy 18.31 10.43 13 166025 220 29786220
Hypersensitivity 18.30 10.43 410 165628 53618 29732822
Neoplasm progression 18.24 10.43 46 165992 17977 29768463
Tumour lysis syndrome 18.17 10.43 27 166011 12858 29773582
Haemoglobin decreased 17.99 10.43 488 165550 113610 29672830
Blood urine 17.96 10.43 17 166021 438 29786002
Trisomy 18 17.82 10.43 13 166025 230 29786210
Social avoidant behaviour 17.77 10.43 45 165993 2818 29783622
Mean platelet volume increased 17.74 10.43 16 166022 387 29786053
Seizure 17.73 10.43 413 165625 98062 29688378
Blood pressure increased 17.40 10.43 522 165516 71406 29715034
Hepatitis B 17.32 10.43 6 166032 6066 29780374
Sneezing 17.20 10.43 58 165980 4269 29782171
Urticaria 17.13 10.43 410 165628 54196 29732244
Product cleaning inadequate 17.10 10.43 5 166033 6 29786434
Cystitis haemorrhagic 17.00 10.43 3 166035 4784 29781656
Food allergy 16.98 10.43 23 166015 885 29785555
Second primary malignancy 16.92 10.43 7 166031 6349 29780091
Pancreatitis acute 16.88 10.43 79 165959 25616 29760824
Drug eruption 16.77 10.43 46 165992 17480 29768960
Appendicolith 16.77 10.43 23 166015 896 29785544
Accessory spleen 16.62 10.43 11 166027 165 29786275
Pulmonary hypertension 16.60 10.43 170 165868 18866 29767574
Mycotic allergy 16.57 10.43 11 166027 166 29786274
Sleep disorder 16.55 10.43 208 165830 24271 29762169
Proteinuria 16.50 10.43 41 165997 16104 29770336
Attention-seeking behaviour 16.44 10.43 7 166031 39 29786401
Sarcopenia 16.43 10.43 13 166025 261 29786179
Cystic fibrosis related diabetes 16.34 10.43 10 166028 130 29786310
Chest injury 16.22 10.43 28 166010 1336 29785104
Hepatitis cholestatic 16.15 10.43 12 166026 7860 29778580
Renal injury 16.13 10.43 25 166013 11704 29774736
Ventricular hyperkinesia 16.09 10.43 12 166026 220 29786220
Mitral valve thickening 16.09 10.43 12 166026 220 29786220
Myelodysplastic syndrome 16.01 10.43 52 165986 18726 29767714
Mood swings 15.96 10.43 84 165954 7542 29778898
Squamous cell carcinoma 15.94 10.43 20 166018 10230 29776210
Rhinalgia 15.93 10.43 15 166023 384 29786056
Metabolic acidosis 15.87 10.43 132 165906 37329 29749111
Shock 15.79 10.43 69 165969 22790 29763650
Febrile bone marrow aplasia 15.78 10.43 13 166025 8084 29778356
Cytomegalovirus viraemia 15.76 10.43 6 166032 5723 29780717
Hepatocellular carcinoma 15.75 10.43 18 166020 9592 29776848
Low birth weight baby 15.69 10.43 7 166031 6069 29780371
Influenza B virus test positive 15.69 10.43 9 166029 103 29786337
Spinal muscular atrophy 15.65 10.43 11 166027 183 29786257
Respiratory syncytial virus bronchiolitis 15.58 10.43 15 166023 395 29786045
Ileus 15.51 10.43 40 165998 15515 29770925
Red cell distribution width increased 15.51 10.43 54 165984 4040 29782400
Eosinophilic bronchitis 15.49 10.43 7 166031 46 29786394
Sensory integrative dysfunction 15.49 10.43 6 166032 25 29786415
Tracheostomy malfunction 15.36 10.43 7 166031 47 29786393
Psoriatic arthropathy 15.36 10.43 41 165997 15720 29770720
Incorrect dose administered 15.36 10.43 254 165784 31432 29755008
General physical health deterioration 15.36 10.43 429 165609 99515 29686925
Infective exacerbation of bronchiectasis 15.34 10.43 16 166022 465 29785975
Migraine 15.33 10.43 123 165915 12751 29773689
Acute myocardial infarction 15.31 10.43 204 165834 52735 29733705
Cortisol decreased 15.30 10.43 22 166016 896 29785544
Device related infection 15.30 10.43 46 165992 16969 29769471
Adenoidectomy 15.24 10.43 7 166031 48 29786392
Blood alkaline phosphatase increased 15.20 10.43 107 165931 31380 29755060
C-reactive protein abnormal 15.15 10.43 6 166032 5587 29780853
Tracheomalacia 15.11 10.43 10 166028 150 29786290
Eye pruritus 15.05 10.43 52 165986 3875 29782565
Venoocclusive liver disease 15.02 10.43 9 166029 6604 29779836
Aplastic anaemia 14.99 10.43 6 166032 5550 29780890
Anxiety 14.74 10.43 624 165414 89247 29697193
Peripheral swelling 14.70 10.43 443 165595 60631 29725809
Humidity intolerance 14.62 10.43 6 166032 30 29786410
Cystic fibrosis lung 14.61 10.43 8 166030 83 29786357
Disorientation 14.57 10.43 108 165930 31310 29755130
Eosinophilia 14.43 10.43 187 165851 21973 29764467
Accelerated idioventricular rhythm 14.34 10.43 7 166031 56 29786384
Dysphonia 14.30 10.43 165 165873 18867 29767573
Cerebral artery thrombosis 14.28 10.43 16 166022 505 29785935
Acute generalised exanthematous pustulosis 14.28 10.43 8 166030 6090 29780350
Lacrimal disorder 14.26 10.43 13 166025 319 29786121
Cerebrovascular accident 14.22 10.43 353 165685 83124 29703316
Anuria 14.17 10.43 22 166016 10294 29776146
Communication disorder 14.10 10.43 35 166003 2165 29784275
Anosmia 14.08 10.43 34 166004 2066 29784374
Palpitations 14.08 10.43 263 165775 33310 29753130
Foreign body aspiration 14.05 10.43 10 166028 170 29786270
Cholestasis 13.98 10.43 81 165957 24869 29761571
Haemorrhage 13.90 10.43 176 165862 45903 29740537
Haematochezia 13.86 10.43 122 165916 34100 29752340
Toxic skin eruption 13.74 10.43 25 166013 10990 29775450
Mucormycosis 13.71 10.43 6 166032 5262 29781178
Acute graft versus host disease in skin 13.70 10.43 4 166034 4512 29781928
Left atrial enlargement 13.68 10.43 15 166023 462 29785978
Hernia pain 13.65 10.43 11 166027 227 29786213
Multiple allergies 13.63 10.43 34 166004 2109 29784331
Decreased gait velocity 13.62 10.43 8 166030 96 29786344
Extrapyramidal disorder 13.58 10.43 24 166014 10669 29775771
Nervous system disorder 13.50 10.43 33 166005 13036 29773404
Klebsiella infection 13.49 10.43 11 166027 6876 29779564
Stridor 13.35 10.43 35 166003 2239 29784201
Hypotension 13.28 10.43 945 165093 199620 29586820
Chronic respiratory disease 13.21 10.43 6 166032 40 29786400
Blebitis 13.17 10.43 4 166034 6 29786434
Renal tubular necrosis 13.17 10.43 42 165996 15209 29771231
Jaundice 13.08 10.43 116 165922 32370 29754070
Post-tussive vomiting 13.07 10.43 5 166033 20 29786420
Gait disturbance 13.07 10.43 315 165723 74462 29711978
Intentional device misuse 13.02 10.43 11 166027 243 29786197
Personal relationship issue 12.95 10.43 9 166029 147 29786293
Gastroenteritis viral 12.86 10.43 66 165972 5867 29780573
Osteonecrosis 12.86 10.43 46 165992 16089 29770351
Therapy non-responder 12.83 10.43 103 165935 29350 29757090
Adrenocortical insufficiency acute 12.81 10.43 25 166013 1312 29785128
Withdrawal syndrome 12.76 10.43 27 166011 11223 29775217
Hot flush 12.75 10.43 131 165907 14549 29771891
Weaning failure 12.72 10.43 11 166027 251 29786189
Prolonged expiration 12.71 10.43 10 166028 199 29786241
Lacunar stroke 12.69 10.43 8 166030 110 29786330
Subdural haematoma 12.66 10.43 58 165980 18914 29767526
Sinus operation 12.65 10.43 17 166021 649 29785791
Nervous system neoplasm 12.64 10.43 9 166029 153 29786287
Headache 12.63 10.43 1174 164864 181132 29605308
Obesity 12.62 10.43 86 165952 8469 29777971
Occupational asthma 12.60 10.43 3 166035 0 29786440
Ventricular pre-excitation 12.60 10.43 3 166035 0 29786440
Vascular shunt 12.60 10.43 3 166035 0 29786440
Emergency care examination 12.60 10.43 3 166035 0 29786440
Vitamin A decreased 12.60 10.43 3 166035 0 29786440
Flail chest 12.60 10.43 3 166035 0 29786440
Physical product label issue 12.60 10.43 3 166035 0 29786440
Bed bug infestation 12.60 10.43 3 166035 0 29786440
Parkinsonism 12.59 10.43 13 166025 7256 29779184
Hypercalcaemia 12.56 10.43 32 166006 12463 29773977
Device failure 12.55 10.43 33 166005 2115 29784325
Hypopnoea 12.49 10.43 23 166015 1155 29785285
Renal disorder 12.46 10.43 78 165960 23506 29762934
Percussion test abnormal 12.45 10.43 4 166034 8 29786432
Electrocardiogram QT shortened 12.44 10.43 9 166029 157 29786283
Alveolar bone resorption 12.35 10.43 5 166033 24 29786416
Polyp 12.30 10.43 43 165995 3223 29783217
Blood creatine phosphokinase increased 12.30 10.43 170 165868 43678 29742762
Bone deformity 12.29 10.43 6 166032 48 29786392
Respiratory acidosis 12.26 10.43 51 165987 4151 29782289
Lymphopenia 12.26 10.43 35 166003 13128 29773312
Oxygen consumption increased 12.24 10.43 24 166014 1264 29785176
Haemolytic anaemia 12.24 10.43 23 166015 9987 29776453
Device ineffective 12.18 10.43 5 166033 25 29786415
Pharyngeal paraesthesia 12.18 10.43 13 166025 388 29786052
Transaminases increased 12.18 10.43 78 165960 23379 29763061
Haematuria 12.16 10.43 175 165863 44659 29741781
Airway remodelling 12.13 10.43 7 166031 81 29786359
Oliguria 12.12 10.43 14 166024 7425 29779015
Poisoning deliberate 12.11 10.43 9 166029 5895 29780545
Anger 12.04 10.43 104 165934 11016 29775424
Nasal discomfort 12.04 10.43 23 166015 1188 29785252
Hypochromasia 12.01 10.43 12 166026 331 29786109
Hypertrophic osteoarthropathy 11.99 10.43 7 166031 83 29786357
Hyperuricaemia 11.95 10.43 14 166024 7380 29779060
Mouth swelling 11.94 10.43 27 166011 1572 29784868
Hepatic steatosis 11.91 10.43 42 165996 14751 29771689
Crying 11.89 10.43 62 165976 5547 29780893
Carcinoid tumour of the gastrointestinal tract 11.88 10.43 6 166032 52 29786388
Emotional disorder of childhood 11.87 10.43 5 166033 27 29786413
Enterococcal infection 11.82 10.43 17 166021 8207 29778233
Apnoeic attack 11.80 10.43 11 166027 278 29786162
Lupus pneumonitis 11.78 10.43 6 166032 53 29786387
Grunting 11.78 10.43 12 166026 339 29786101
Metastases to liver 11.75 10.43 31 166007 11934 29774506
Panic reaction 11.73 10.43 25 166013 1398 29785042
Respiratory tract infection bacterial 11.71 10.43 15 166023 546 29785894
Therapy partial responder 11.70 10.43 3 166035 3688 29782752
Transposition of the great vessels 11.63 10.43 14 166024 478 29785962
Aptyalism 11.61 10.43 10 166028 227 29786213
Expiratory reserve volume decreased 11.59 10.43 6 166032 55 29786385
Throat clearing 11.50 10.43 10 166028 230 29786210
Cytomegalovirus test positive 11.48 10.43 3 166035 3642 29782798
Hypoalbuminaemia 11.47 10.43 28 166010 11064 29775376
Pancreatic carcinoma 11.46 10.43 16 166022 7821 29778619
Walking aid user 11.44 10.43 25 166013 1422 29785018
Sputum retention 11.38 10.43 14 166024 489 29785951
Blood urea increased 11.37 10.43 115 165923 31266 29755174
Mycobacterium avium complex infection 11.37 10.43 37 166001 2674 29783766
Colon cancer 11.36 10.43 18 166020 8354 29778086
Somnolence 11.36 10.43 430 165608 96333 29690107
Pneumonia pseudomonal 11.31 10.43 44 165994 3474 29782966
Paraneoplastic rash 11.31 10.43 7 166031 93 29786347
Malpositioned teeth 11.31 10.43 5 166033 31 29786409
Hyperkalaemia 11.28 10.43 279 165759 65731 29720709
Chronic kidney disease 11.23 10.43 145 165893 37693 29748747
Blood gases abnormal 11.17 10.43 11 166027 298 29786142
Renal tubular disorder 11.11 10.43 7 166031 4999 29781441
Dehydration 11.01 10.43 566 165472 122973 29663467
Expired product administered 11.00 10.43 38 166000 2831 29783609
Dizziness postural 10.95 10.43 60 165978 5470 29780970
Pulmonary pain 10.93 10.43 12 166026 370 29786070
Tearfulness 10.88 10.43 26 166012 1570 29784870
Pigment dispersion syndrome 10.86 10.43 4 166034 14 29786426
Drug hypersensitivity 10.80 10.43 293 165745 68226 29718214
Lung transplant 10.75 10.43 29 166009 1887 29784553
Cervicogenic headache 10.65 10.43 4 166034 15 29786425
Forced expiratory volume increased 10.65 10.43 4 166034 15 29786425
Exposure via skin contact 10.65 10.43 4 166034 15 29786425
Bradycardia 10.65 10.43 279 165759 65247 29721193
Hemiparesis 10.64 10.43 44 165994 14758 29771682
Tracheitis 10.60 10.43 15 166023 602 29785838
Oropharyngeal discomfort 10.54 10.43 25 166013 1502 29784938
Exposure to fungus 10.54 10.43 3 166035 3 29786437
Forced expiratory volume abnormal 10.54 10.43 3 166035 3 29786437
Blastocystis infection 10.54 10.43 3 166035 3 29786437
Implant site necrosis 10.54 10.43 3 166035 3 29786437
Gastric haemorrhage 10.51 10.43 23 166015 9444 29776996
Intentional self-injury 10.51 10.43 39 165999 13493 29772947
Pulmonary tuberculosis 10.50 10.43 7 166031 4850 29781590
Drug level decreased 10.49 10.43 10 166028 5795 29780645
Atypical mycobacterial lower respiratory tract infection 10.46 10.43 5 166033 38 29786402

Pharmacologic Action:

SourceCodeDescription
ATC R03AC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03CC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
ATC R03AK04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
FDA MoA N0000009922 Adrenergic beta2-Agonists
FDA EPC N0000175779 beta2-Adrenergic Agonist
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D015149 Tocolytic Agents
CHEBI has role CHEBI:35522 beta-adrenergic receptor agonist
CHEBI has role CHEBI:35523 bronchodilator agents
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bronchospasm indication 4386001
Acute exacerbation of asthma indication 708038006
Bronchospasm Prevention indication
Exercise-Induced Bronchospasm Prevention indication
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Ketoacidosis contraindication 56051008
Metabolic acidosis contraindication 59455009
Diabetes mellitus contraindication 73211009 DOID:9351
Paradoxical bronchospasm contraindication 102578005
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Myocardial ischemia contraindication 414795007 DOID:3393
Congenital long QT syndrome contraindication 442917000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.07 acidic
pKa2 9.46 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST Ki 5.95 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.61 PDSP
Beta-2 adrenergic receptor GPCR Kd 6.28 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.94 CHEMBL

External reference:

IDSource
QF8SVZ843E UNII
4018796 VUID
N0000147099 NUI
D02147 KEGG_DRUG
51022-70-9 SECONDARY_CAS_RN
C0001927 UMLSCUI
CHEBI:2549 CHEBI
68H PDB_CHEM_ID
CHEMBL714 ChEMBL_ID
CHEMBL1201026 ChEMBL_ID
CHEMBL1441059 ChEMBL_ID
DB01001 DRUGBANK_ID
D000420 MESH_DESCRIPTOR_UI
2083 PUBCHEM_CID
2585 INN_ID
558 IUPHAR_LIGAND_ID
142153 RXNORM
3007 MMSL
30960 MMSL
4143 MMSL
4144 MMSL
46702 MMSL
d00749 MMSL
001814 NDDF
001815 NDDF
372897005 SNOMEDCT_US
48474002 SNOMEDCT_US
91143003 SNOMEDCT_US
4018796 VANDF
4018797 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 26 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0254-1007 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0255 TABLET 2 mg ORAL ANDA 23 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0572 TABLET 4 mg ORAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6991 SOLUTION 0.75 mg RESPIRATORY (INHALATION) NDA authorized generic 25 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6992 SOLUTION 1.50 mg RESPIRATORY (INHALATION) NDA authorized generic 25 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-8270 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 24 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0378-9671 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0472-0825 SYRUP 2 mg ORAL ANDA 22 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0487-0201 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-0301 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9501 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9901 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9904 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3467 SOLUTION 0.63 mg INTRABRONCHIAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3468 SOLUTION 1.25 mg INTRABRONCHIAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3797 SOLUTION 2.50 mg INTRABRONCHIAL ANDA 21 sections
Combivent Respimat HUMAN PRESCRIPTION DRUG LABEL 2 0597-0024 SPRAY, METERED 100 ug RESPIRATORY (INHALATION) NDA 27 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0781-7146 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7155 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7296 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 16590-339 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 27 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 17856-0740 SYRUP 2 mg ORAL ANDA 19 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 21695-198 AEROSOL, METERED 90 ug ORAL ANDA 24 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-245 SOLUTION 5 mg RESPIRATORY (INHALATION) ANDA 18 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-332 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-350 SYRUP 2 mg ORAL ANDA 19 sections