salbutamol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 105 18559-94-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salbutamol
  • albuterol
  • sabumol
  • dl-Albuterol
  • dl-Salbutamol
  • albuterol sulfate
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
  • Molecular weight: 239.32
  • Formula: C13H21NO3
  • CLOGP: 0.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -2.05
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
10 mg Inhal.solution
12 mg O
12 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.23 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.92 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 68 mg/mL Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 44 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
BA (Bioavailability) 0.44 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.458 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.076 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.592 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 3.350 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 89.530 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 81.220 % High 1
herg hERG pIC50 4.056 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.553 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.648 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 90.460 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PLK2,PLK3,PLK4,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 57
kinase-selectivity-class ACVRL1,AXL,BRAF,CDK4,EIF2AK3,EPHB4,GRK2,MAP2K6,TEK,TGFBR1 10
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.782 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.288 High 1
mh-clint Mouse hepatocyte intrinsic clearance 12.274 High 1
mppb Mouse plasma protein binding (% unbound) 92.950 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.227 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 91.100 % High 1
rat-kpuu-brain Rat brain Kpuu 0.009 % High 1
rh-clint Rat hepatocyte intrinsic clearance 5.297 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 91.150 % High 1
rppb Rat plasma protein binding (% unbound) 84 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 859.014 uM High 1

Approvals:

DateAgencyCompanyOrphan
May 1, 1981 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 6139.31 9.61 7416 538068 234744 89848219
Dyspnoea 3105.37 9.61 11952 533532 869003 89213960
Cough 2343.28 9.61 6144 539340 362818 89720145
Obstructive airways disorder 2257.37 9.61 1588 543896 24281 90058682
Wheezing 2179.13 9.61 4576 540908 233504 89849459
Full blood count abnormal 1700.07 9.61 1552 543932 35045 90047918
Productive cough 1444.75 9.61 2038 543446 75025 90007938
Sleep disorder due to a general medical condition 1404.02 9.61 1533 543951 43205 90039758
Pemphigus 1369.45 9.61 176 545308 326688 89756275
Chronic obstructive pulmonary disease 1365.57 9.61 1940 543544 71889 90011074
Poor quality device used 1334.12 9.61 507 544977 1786 90081177
Synovitis 1176.85 9.61 271 545213 329481 89753482
Systemic lupus erythematosus 1158.86 9.61 368 545116 361528 89721435
Hand deformity 1131.08 9.61 208 545276 296154 89786809
Chest discomfort 1098.95 9.61 2514 542970 135851 89947112
Glossodynia 1096.67 9.61 291 545193 321488 89761475
Sputum discoloured 1004.50 9.61 894 544590 19497 90063466
Forced expiratory volume decreased 973.40 9.61 540 544944 5268 90077695
Arthropathy 863.16 9.61 572 544912 365670 89717293
Pericarditis 841.15 9.61 288 545196 269863 89813100
Wound 803.55 9.61 410 545074 302570 89780393
Anti-cyclic citrullinated peptide antibody positive 773.38 9.61 231 545253 236202 89846761
Alopecia 762.13 9.61 1125 544359 493946 89589017
Helicobacter infection 748.63 9.61 218 545266 226632 89856331
Infective pulmonary exacerbation of cystic fibrosis 744.57 9.61 564 544920 9715 90073248
Duodenal ulcer perforation 688.61 9.61 236 545248 221052 89861911
Bronchitis 661.79 9.61 2226 543258 150701 89932262
Treatment failure 654.28 9.61 522 544962 303406 89779557
Completed suicide 624.52 9.61 71 545413 144987 89937976
Product dose omission issue 624.04 9.61 3428 542056 288259 89794704
Product quality issue 618.05 9.61 1431 544053 77894 90005069
Contraindicated product administered 613.41 9.61 613 544871 319526 89763437
Pneumonia 596.44 9.61 6161 539323 631898 89451065
Nasal congestion 566.50 9.61 1427 544057 81987 90000976
Therapeutic product effect decreased 563.93 9.61 504 544980 277067 89805896
Infusion related reaction 563.72 9.61 1030 544454 415750 89667213
Nasal polyps 557.79 9.61 488 544996 10392 90072571
Off label use 551.65 9.61 4132 541352 1098120 88984843
Impaired quality of life 529.76 9.61 675 544809 22469 90060494
Drug intolerance 519.95 9.61 1207 544277 446384 89636579
Liver injury 510.03 9.61 194 545290 170373 89912590
Abdominal discomfort 509.34 9.61 1345 544139 475983 89606980
Middle insomnia 487.51 9.61 552 544932 16199 90066764
Impaired healing 485.62 9.61 417 545067 233782 89849181
Rheumatic fever 468.18 9.61 168 545316 152953 89930010
Folliculitis 460.01 9.61 335 545149 204018 89878945
Dyspnoea exertional 453.05 9.61 1200 544284 71088 90011875
Swelling 452.90 9.61 1173 544311 417885 89665078
Muscle injury 441.92 9.61 257 545227 176397 89906566
Rhinitis allergic 439.75 9.61 524 544960 16261 90066702
Illness 432.34 9.61 1278 544206 80691 90002272
Psoriatic arthropathy 427.19 9.61 446 545038 227889 89855074
Maternal exposure during pregnancy 420.35 9.61 968 544516 359095 89723868
Irritable bowel syndrome 417.25 9.61 380 545104 207068 89875895
Stomatitis 413.59 9.61 633 544851 274065 89808898
Loss of personal independence in daily activities 403.66 9.61 1757 543727 134348 89948615
Rheumatoid factor positive 402.70 9.61 269 545215 171381 89911582
Hepatic enzyme increased 401.88 9.61 994 544490 359742 89723221
Bronchiectasis 395.36 9.61 575 544909 21755 90061208
Eosinophil count increased 377.17 9.61 429 545055 12652 90070311
Sleep apnoea syndrome 368.15 9.61 675 544809 31072 90051891
Musculoskeletal stiffness 365.07 9.61 774 544710 295758 89787205
Upper respiratory tract infection 363.49 9.61 1634 543850 126684 89956279
Upper-airway cough syndrome 363.21 9.61 452 545032 14683 90068280
Blood immunoglobulin E increased 359.10 9.61 260 545224 4165 90078798
Device delivery system issue 358.68 9.61 187 545297 1591 90081372
General physical health deterioration 351.50 9.61 1037 544447 354078 89728885
Respiratory disorder 343.14 9.61 1012 544472 63804 90019159
Dysphonia 337.83 9.61 989 544495 62095 90020868
Therapeutic product effect incomplete 328.51 9.61 2145 543339 191751 89891212
Food allergy 322.72 9.61 563 544921 24915 90058048
Intentional product use issue 318.57 9.61 508 544976 216384 89866579
Rales 316.46 9.61 432 545052 15395 90067568
Dermatitis atopic 312.16 9.61 530 544954 22942 90060021
Neutropenia 311.62 9.61 547 544937 224357 89858606
Drug ineffective 307.99 9.61 6186 539298 1378112 88704851
Discomfort 306.12 9.61 755 544729 273580 89809383
Oropharyngeal pain 303.44 9.61 1436 544048 113751 89969212
Influenza 300.21 9.61 1641 543843 137623 89945340
Breath sounds abnormal 295.68 9.61 412 545072 14974 90067989
C-reactive protein increased 289.56 9.61 401 545083 180988 89901975
Swollen joint count increased 287.84 9.61 155 545329 111051 89971912
Heart rate increased 285.46 9.61 1391 544093 111511 89971452
Pulmonary function test decreased 278.74 9.61 225 545259 4269 90078694
Bronchospasm 275.92 9.61 468 545016 20241 90062722
Ear pain 269.15 9.61 862 544622 56840 90026123
Blood cholesterol increased 266.88 9.61 530 544954 207482 89875481
Blister 261.44 9.61 732 544752 254266 89828697
Joint swelling 258.95 9.61 1869 543615 501431 89581532
Joint range of motion decreased 253.52 9.61 265 545219 135378 89947585
Myelosuppression 252.70 9.61 18 545466 53573 90029390
Pulmonary function test abnormal 238.51 9.61 168 545316 2571 90080392
Secretion discharge 234.35 9.61 376 545108 15520 90067443
Body temperature increased 228.02 9.61 689 544795 44021 90038942
Sleep disorder due to general medical condition, insomnia type 226.67 9.61 264 545220 128430 89954533
Facet joint syndrome 224.29 9.61 159 545325 98230 89984733
Intentional overdose 224.15 9.61 144 545340 93690 89989273
Lip dry 218.73 9.61 172 545312 100783 89982180
Febrile neutropenia 218.49 9.61 386 545098 157963 89925000
Blood test abnormal 215.12 9.61 423 545061 20529 90062434
Rhinorrhoea 214.61 9.61 1076 544408 87240 89995723
Toxicity to various agents 214.07 9.61 947 544537 286899 89796064
Bronchial secretion retention 213.71 9.61 176 545308 3439 90079524
Bronchopulmonary aspergillosis allergic 211.52 9.61 178 545306 3588 90079375
Sedation complication 210.15 9.61 371 545113 16573 90066390
Reversible airways obstruction 206.86 9.61 136 545348 1847 90081116
Cystic fibrosis 206.51 9.61 179 545305 3762 90079201
Malignant neoplasm progression 204.00 9.61 205 545279 106665 89976298
Inflammation 202.67 9.61 487 544997 178105 89904858
Back pain 200.69 9.61 2847 542637 314328 89768635
Drug-induced liver injury 200.62 9.61 150 545334 90168 89992795
Rheumatoid arthritis 199.96 9.61 1319 544165 361295 89721668
Asthmatic crisis 199.26 9.61 131 545353 1779 90081184
Respiratory tract infection 197.99 9.61 792 544692 58286 90024677
Creatinine renal clearance decreased 197.00 9.61 384 545100 18515 90064448
Oxygen saturation decreased 196.10 9.61 1212 544272 106271 89976692
Gastrooesophageal reflux disease 195.90 9.61 1689 543795 164648 89918315
Temperature regulation disorder 194.92 9.61 330 545154 14249 90068714
Epilepsy 189.82 9.61 131 545353 82075 90000888
Headache 189.61 9.61 6650 538834 856096 89226867
Emphysema 188.14 9.61 294 545190 11861 90071102
Type 2 diabetes mellitus 182.97 9.61 619 544865 202625 89880338
Eye pruritus 181.94 9.61 482 545002 28545 90054418
Pancytopenia 181.92 9.61 276 545208 119987 89962976
Gait inability 179.47 9.61 383 545101 146073 89936890
Seasonal allergy 179.33 9.61 415 545069 22568 90060395
Confusional state 179.28 9.61 1475 544009 384730 89698233
Sinus disorder 176.74 9.61 532 544952 33915 90049048
Haemoptysis 176.08 9.61 520 544964 32800 90050163
Swollen tongue 171.93 9.61 638 544846 45318 90037645
Polycystic ovaries 170.81 9.61 190 545294 5464 90077499
Anxiety 170.47 9.61 2715 542769 307057 89775906
Eczema 169.40 9.61 699 544785 52171 90030792
Sensitivity to weather change 167.27 9.61 236 545248 8678 90074285
Ill-defined disorder 166.50 9.61 563 544921 184328 89898635
Respiration abnormal 166.28 9.61 222 545262 7741 90075222
Pulmonary mass 165.58 9.61 463 545021 28309 90054654
Eosinophilia 165.03 9.61 460 545024 28073 90054890
Hip arthroplasty 163.62 9.61 131 545353 76077 90006886
Eosinophilic bronchitis 163.15 9.61 79 545405 564 90082399
No adverse event 162.86 9.61 825 544659 67157 90015806
Onychomadesis 161.47 9.61 39 545445 45959 90037004
Nail disorder 160.80 9.61 77 545407 58990 90023973
Orthostatic hypotension 158.42 9.61 583 544901 41244 90041719
Blepharospasm 157.61 9.61 68 545416 55377 90027586
Gastrointestinal disorder 156.87 9.61 904 544580 255783 89827180
Drug abuse 149.26 9.61 165 545319 82182 90000781
C-reactive protein abnormal 148.93 9.61 342 545142 127087 89955876
Prescribed underdose 148.86 9.61 139 545345 74880 90008083
Lip swelling 148.62 9.61 541 544943 38069 90044894
Musculoskeletal pain 146.45 9.61 533 544951 170718 89912245
Peak expiratory flow rate decreased 145.40 9.61 73 545411 569 90082394
Therapy non-responder 144.83 9.61 386 545098 136318 89946645
Injury 144.40 9.61 653 544831 196696 89886267
Chest X-ray abnormal 143.69 9.61 165 545319 4917 90078046
Blood calcium decreased 143.57 9.61 454 545030 29728 90053235
Fibromyalgia 142.99 9.61 696 544788 205573 89877390
Hypercholesterolaemia 140.90 9.61 244 545240 100648 89982315
Respiratory tract congestion 140.32 9.61 423 545061 26987 90055976
Anaphylactic reaction 139.50 9.61 954 544530 86570 89996393
Sputum increased 138.42 9.61 126 545358 2831 90080132
Allergy to animal 138.37 9.61 99 545385 1555 90081408
Forced vital capacity decreased 138.22 9.61 87 545397 1091 90081872
COVID-19 137.81 9.61 1589 543895 167254 89915709
Peripheral venous disease 137.43 9.61 182 545302 83739 89999224
Sensitisation 136.04 9.61 146 545338 4029 90078934
Acute respiratory failure 135.59 9.61 565 544919 42353 90040610
Anaemia 135.37 9.61 1413 544071 351389 89731574
Total lung capacity increased 135.24 9.61 159 545325 4862 90078101
Knee arthroplasty 134.59 9.61 182 545302 83000 89999963
Wrong technique in device usage process 133.23 9.61 170 545314 5665 90077298
Incorrect dose administered 132.80 9.61 872 544612 78058 90004905
White blood cell count decreased 132.65 9.61 536 544948 166573 89916390
Swelling face 132.20 9.61 891 544593 80461 90002502
Product complaint 131.92 9.61 267 545217 13233 90069730
Restrictive pulmonary disease 131.34 9.61 111 545373 2251 90080712
Lung hyperinflation 131.13 9.61 90 545394 1318 90081645
Eosinophilic granulomatosis with polyangiitis 130.73 9.61 114 545370 2416 90080547
Disease progression 129.63 9.61 494 544990 156121 89926842
Bronchial wall thickening 128.59 9.61 105 545379 2026 90080937
Osteoarthritis 128.50 9.61 673 544811 195057 89887906
Asthma-chronic obstructive pulmonary disease overlap syndrome 128.42 9.61 153 545331 4746 90078217
Hypoventilation 126.81 9.61 158 545326 5138 90077825
Wound infection 126.42 9.61 283 545201 106119 89976844
Leukopenia 126.19 9.61 260 545224 100450 89982513
Respiratory rate increased 124.92 9.61 289 545195 15712 90067251
Eosinophil count abnormal 124.90 9.61 73 545411 793 90082170
Onychomycosis 124.88 9.61 35 545449 37341 90045622
Respiratory distress 123.26 9.61 513 544971 38433 90044530
Sputum purulent 122.57 9.61 85 545399 1267 90081696
Throat clearing 120.93 9.61 132 545352 3715 90079248
Respiratory symptom 120.13 9.61 138 545346 4114 90078849
Viral infection 119.15 9.61 530 544954 40884 90042079
Vital capacity decreased 119.06 9.61 94 545390 1725 90081238
Sneezing 118.77 9.61 423 545061 29446 90053517
Burning sensation 117.28 9.61 718 544766 62734 90020229
Drug interaction 116.59 9.61 1082 544402 275371 89807592
Hepatic function abnormal 116.16 9.61 67 545417 46221 90036742
Exposure via skin contact 115.85 9.61 221 545263 10484 90072479
Rash erythematous 114.89 9.61 728 544756 64376 90018587
Balance disorder 114.88 9.61 987 544497 96093 89986870
Immunodeficiency 114.51 9.61 540 544944 42694 90040269
Grip strength decreased 114.31 9.61 241 545243 92335 89990628
Platelet count decreased 114.02 9.61 431 545053 136538 89946425
Sinusitis 113.82 9.61 2786 542698 340302 89742661
Sinus pain 113.69 9.61 151 545333 5238 90077725
Bronchospasm paradoxical 113.65 9.61 39 545445 93 90082870
Bronchial obstruction 112.10 9.61 88 545396 1601 90081362
Device malfunction 111.43 9.61 328 545156 20649 90062314
Sciatica 108.33 9.61 285 545199 101097 89981866
Lung neoplasm malignant 108.11 9.61 357 545127 23916 90059047
Finger deformity 107.71 9.61 32 545452 32865 90050098
C-reactive protein 107.38 9.61 28 545456 31339 90051624
Pharyngeal swelling 107.25 9.61 205 545279 9739 90073224
Live birth 107.13 9.61 195 545289 78912 90004051
Constipation 106.94 9.61 2322 543162 278073 89804890
Dust allergy 106.85 9.61 65 545419 764 90082199
Bacterial disease carrier 106.46 9.61 89 545395 1777 90081186
Palpitations 105.03 9.61 1272 544212 135456 89947507
Hypoaesthesia 104.60 9.61 1299 544185 312911 89770052
Product use issue 104.25 9.61 1379 544105 328540 89754423
Ejection fraction 102.91 9.61 108 545376 2903 90080060
Hyperhidrosis 102.50 9.61 1263 544221 135042 89947921
Rhinitis 101.45 9.61 241 545243 13331 90069632
Product delivery mechanism issue 100.47 9.61 53 545431 463 90082500
Rhonchi 100.32 9.61 106 545378 2872 90080091
Product container issue 100.27 9.61 92 545392 2089 90080874
Taste disorder 100.23 9.61 134 545350 61412 90021551
Throat tightness 100.16 9.61 397 545087 29087 90053876
Cognitive disorder 99.81 9.61 738 544746 68669 90014294
Inappropriate schedule of product administration 99.60 9.61 1358 544126 148575 89934388
Status asthmaticus 99.52 9.61 64 545420 835 90082128
Multiple allergies 99.52 9.61 256 545228 14890 90068073
Hypoxia 99.14 9.61 761 544723 71638 90011325
Product label confusion 98.76 9.61 11 545473 22839 90060124
Total lung capacity decreased 98.62 9.61 118 545366 3677 90079286
Breast cancer stage III 98.37 9.61 227 545257 84220 89998743
Hospitalisation 97.63 9.61 1190 544294 126910 89956053
Arthralgia 97.41 9.61 3767 541717 774755 89308208
Adverse event 97.39 9.61 370 545114 117048 89965915
Sopor 96.72 9.61 16 545468 24628 90058335
Lower limb fracture 96.25 9.61 232 545252 84781 89998182
Circumstance or information capable of leading to medication error 95.43 9.61 133 545351 4834 90078129
Liver disorder 94.32 9.61 392 545092 120877 89962086
Injection site pain 94.15 9.61 1519 543965 172180 89910783
Decreased appetite 93.64 9.61 1648 543836 374892 89708071
Aphonia 93.43 9.61 220 545264 12099 90070864
Fluid retention 92.65 9.61 873 544611 87218 89995745
Ear pruritus 92.29 9.61 155 545329 6648 90076315
Paranasal sinus discomfort 91.69 9.61 147 545337 6063 90076900
Nasal obstruction 91.62 9.61 95 545389 2517 90080446
Multiple drug therapy 91.52 9.61 157 545327 6852 90076111
Angioedema 91.12 9.61 686 544798 64190 90018773
Deep vein thrombosis postoperative 90.24 9.61 181 545303 70628 90012335
Chest pain 90.16 9.61 2541 542943 317104 89765859
Feeling abnormal 89.72 9.61 1460 544024 165775 89917188
Blood pressure increased 88.36 9.61 1673 543811 195544 89887419
Condition aggravated 88.10 9.61 2822 542662 592723 89490240
Animal scratch 87.67 9.61 79 545405 1751 90081212
Red blood cell sedimentation rate increased 87.62 9.61 233 545251 82362 90000601
Polyp 86.69 9.61 161 545323 7483 90075480
Cardiac disorder 86.54 9.61 613 544871 56259 90026704
Hepatocellular injury 86.39 9.61 33 545451 28925 90054038
Myalgia 85.96 9.61 1507 543977 173618 89909345
Blood lactic acid increased 85.05 9.61 173 545311 8605 90074358
Product dose omission in error 84.66 9.61 294 545190 20209 90062754
Suicide attempt 84.38 9.61 207 545277 75192 90007771
Oedema 84.37 9.61 784 544700 199511 89883452
Thrombocytopenia 84.10 9.61 826 544658 207899 89875064
Renal impairment 83.09 9.61 339 545145 105082 89977881
Coma 82.39 9.61 198 545286 72434 90010529
Adverse reaction 82.00 9.61 38 545446 29674 90053289
Mucosal inflammation 81.70 9.61 138 545346 57487 90025476
Humidity intolerance 81.38 9.61 43 545441 377 90082586
Sedation 80.30 9.61 531 544953 47640 90035323
Drug reaction with eosinophilia and systemic symptoms 79.33 9.61 84 545400 42674 90040289
Sarcoidosis 79.21 9.61 189 545295 10484 90072479
Agranulocytosis 79.18 9.61 57 545427 34945 90048018
Hiatus hernia 77.87 9.61 331 545153 25030 90057933
Emotional distress 77.58 9.61 430 545054 36232 90046731
Alveolar osteitis 77.42 9.61 61 545423 1116 90081847
Depressed mood 77.40 9.61 543 544941 49679 90033284
Urinary tract discomfort 77.24 9.61 55 545429 857 90082106
Product cleaning inadequate 77.08 9.61 21 545463 12 90082951
Alanine aminotransferase increased 77.02 9.61 408 545076 117930 89965033
Metastases to liver 76.22 9.61 39 545445 28768 90054195
Lung opacity 76.18 9.61 134 545350 5968 90076995
Cardiac murmur 76.08 9.61 262 545222 17932 90065031
Toxic epidermal necrolysis 74.86 9.61 52 545432 32476 90050487
Posterior reversible encephalopathy syndrome 74.48 9.61 21 545463 22318 90060645
Mite allergy 74.25 9.61 52 545432 788 90082175
Lacrimation increased 73.12 9.61 340 545144 26722 90056241
Obesity 73.07 9.61 356 545128 105151 89977812
Macular degeneration 72.25 9.61 73 545411 37897 90045066
Respiratory failure 71.99 9.61 1056 544428 117362 89965601
Liver function test increased 71.92 9.61 265 545219 84590 89998373
Nasal discharge discolouration 71.35 9.61 87 545397 2766 90080197
Bone marrow failure 70.91 9.61 54 545430 32167 90050796
Conjunctivitis allergic 70.81 9.61 61 545423 1271 90081692
Dry mouth 70.58 9.61 737 544747 183322 89899641
Choking 68.60 9.61 193 545291 11840 90071123
Foetal death 67.96 9.61 276 545208 20447 90062516
Rheumatoid nodule 67.15 9.61 19 545465 20147 90062816
Neutrophil count decreased 66.29 9.61 215 545269 71317 90011646
Cytomegalovirus infection 66.05 9.61 39 545445 26563 90056400
Mobility decreased 65.64 9.61 1087 544397 249647 89833316
Nasal turbinate hypertrophy 65.52 9.61 50 545434 871 90082092
Multiple organ dysfunction syndrome 65.00 9.61 203 545281 68133 90014830
Cholestasis 64.39 9.61 74 545410 36225 90046738
Proctitis 64.32 9.61 8 545476 15251 90067712
Human rhinovirus test positive 64.19 9.61 49 545435 854 90082109
Drug dependence 64.08 9.61 347 545137 28980 90053983
Limb injury 63.66 9.61 365 545119 31143 90051820
Septic shock 63.62 9.61 275 545209 83885 89999078
Tunnel vision 63.54 9.61 64 545420 1637 90081326
Drug resistance 63.30 9.61 54 545430 30395 90052568
Panic attack 63.15 9.61 320 545164 26045 90056918
Poisoning deliberate 61.89 9.61 12 545472 16474 90066489
Throat irritation 61.81 9.61 503 544981 48192 90034771
Hepatic cytolysis 61.66 9.61 57 545427 30859 90052104
Bronchial hyperreactivity 61.56 9.61 68 545416 1940 90081023
Cardio-respiratory arrest 61.17 9.61 186 545298 62954 90020009
Aspartate aminotransferase increased 60.44 9.61 367 545117 102570 89980393
Pulmonary embolism 60.38 9.61 1115 544369 129705 89953258
Sinus operation 60.34 9.61 82 545402 2909 90080054
Vaginal flatulence 60.29 9.61 4 545480 12634 90070329
Cytokine release syndrome 60.14 9.61 48 545436 27925 90055038
Blood pressure systolic increased 59.75 9.61 575 544909 57770 90025193
Lung diffusion test abnormal 59.48 9.61 32 545452 292 90082671
Respiratory syncytial virus test positive 59.41 9.61 50 545434 1008 90081955
Lung diffusion test decreased 58.86 9.61 45 545439 786 90082177
Sputum culture positive 58.46 9.61 70 545414 2183 90080780
Smoke sensitivity 58.44 9.61 37 545447 469 90082494
Serotonin syndrome 58.19 9.61 86 545398 37801 90045162
Neoplasm progression 58.16 9.61 112 545372 44374 90038589
Exposure to allergen 58.05 9.61 38 545446 512 90082451
Muscle spasticity 58.05 9.61 388 545096 34934 90048029
Perfume sensitivity 57.89 9.61 48 545436 947 90082016
Acute kidney injury 57.70 9.61 1477 544007 318910 89764053
Increased bronchial secretion 57.69 9.61 68 545416 2085 90080878
Anosmia 57.17 9.61 159 545325 9689 90073274
Haematotoxicity 56.88 9.61 5 545479 12530 90070433
Chills 56.16 9.61 1111 544373 130870 89952093
Prolonged expiration 55.80 9.61 52 545432 1205 90081758
Panniculitis 55.39 9.61 10 545474 14448 90068515
Blood potassium decreased 55.27 9.61 483 545001 47244 90035719
Stress 54.75 9.61 739 544745 80656 90002307
Pulmonary congestion 54.62 9.61 247 545237 19186 90063777
Back injury 54.55 9.61 125 545359 46497 90036466
Palmar-plantar erythrodysaesthesia syndrome 54.33 9.61 53 545431 27970 90054993
Ear congestion 54.31 9.61 84 545400 3358 90079605
Injection site scab 53.22 9.61 39 545445 637 90082326
Ejection fraction abnormal 52.86 9.61 70 545414 2421 90080542
Tremor 51.96 9.61 1248 544236 151925 89931038
Bronchial disorder 51.91 9.61 55 545429 1495 90081468
Respiratory tract inflammation 51.61 9.61 37 545447 583 90082380
Sinusitis fungal 50.92 9.61 61 545423 1903 90081060
Vocal cord dysfunction 50.92 9.61 43 545441 871 90082092
Drug hypersensitivity 50.88 9.61 2276 543208 461333 89621630
Thrombotic microangiopathy 50.30 9.61 16 545468 15727 90067236
Hypothyroidism 50.24 9.61 515 544969 52612 90030351
Blood parathyroid hormone decreased 50.07 9.61 7 545477 12209 90070754
Neurotoxicity 49.82 9.61 34 545450 21433 90061530
Therapy partial responder 49.73 9.61 36 545448 22007 90060956
Exercise tolerance decreased 48.96 9.61 127 545357 7424 90075539
Increased upper airway secretion 48.47 9.61 85 545399 3776 90079187
Malaise 48.22 9.61 4124 541360 581862 89501101
Cardiotoxicity 47.94 9.61 6 545478 11383 90071580
Nicotine dependence 47.70 9.61 44 545440 1006 90081957
Decreased activity 47.30 9.61 132 545352 8060 90074903
Altered state of consciousness 47.05 9.61 73 545411 31459 90051504
Carpal tunnel syndrome 46.91 9.61 275 545209 23653 90059310
Infective exacerbation of chronic obstructive airways disease 46.73 9.61 51 545433 1435 90081528
Drug eruption 46.41 9.61 89 545395 35318 90047645
Inhalation therapy 46.16 9.61 15 545469 28 90082935
Forced expiratory volume abnormal 46.05 9.61 20 545464 107 90082856
Tubulointerstitial nephritis 45.67 9.61 51 545433 25292 90057671
Foreign body in reproductive tract 45.28 9.61 45 545439 1132 90081831
Depression 45.25 9.61 2228 543256 298373 89784590
Cholecystitis chronic 45.08 9.61 146 545338 9680 90073283
Bronchial neoplasm 44.97 9.61 32 545452 498 90082465
Lower respiratory tract congestion 44.91 9.61 76 545408 3280 90079683
Road traffic accident 44.56 9.61 423 545061 107203 89975760
Acute hepatic failure 44.52 9.61 42 545442 22519 90060444
Rib fracture 44.42 9.61 292 545192 26143 90056820
Forced expiratory flow decreased 44.31 9.61 19 545465 98 90082865
Hyper IgE syndrome 44.03 9.61 31 545453 474 90082489
Respiratory syncytial virus infection 43.89 9.61 151 545333 10329 90072634
Autoimmune disorder 43.81 9.61 276 545208 76468 90006495
Viral test positive 43.76 9.61 34 545450 609 90082354
Myelodysplastic syndrome 43.54 9.61 37 545447 20866 90062097
Seronegative arthritis 43.51 9.61 28 545456 18206 90064757
Pruritus 43.12 9.61 3802 541682 537723 89545240
Shock 42.58 9.61 67 545417 28711 90054252
Rhinovirus infection 42.54 9.61 104 545380 5859 90077104
Respiratory gas exchange disorder 42.54 9.61 28 545456 381 90082582
Blood iron decreased 42.33 9.61 217 545267 17742 90065221
Metastases to bone 42.07 9.61 55 545429 25450 90057513
Spirometry abnormal 41.84 9.61 24 545460 251 90082712
Cardiac failure congestive 41.71 9.61 830 544654 97864 89985099
Frustration tolerance decreased 41.49 9.61 123 545361 7773 90075190
Bronchial haemorrhage 41.15 9.61 33 545451 620 90082343
Hepatitis 41.11 9.61 253 545231 70486 90012477
Cystic fibrosis respiratory infection suppression 41.11 9.61 26 545458 329 90082634
Hepatotoxicity 40.95 9.61 140 545344 45702 90037261
Rash 40.89 9.61 4182 541302 791918 89291045
Lower respiratory tract infection 40.72 9.61 1872 543612 248787 89834176
Bladder pain 40.70 9.61 65 545419 2672 90080291
Injection site reaction 40.68 9.61 356 545128 91724 89991239
Sputum retention 40.58 9.61 33 545451 633 90082330
Mast cell activation syndrome 40.50 9.61 49 545435 1545 90081418
Product taste abnormal 40.17 9.61 61 545423 2399 90080564
Acute myeloid leukaemia 40.05 9.61 39 545445 20601 90062362
Dry skin 40.05 9.61 749 544735 87324 89995639
Superinfection 39.71 9.61 69 545415 3043 90079920
Foot deformity 39.17 9.61 205 545279 59446 90023517
Salpingo-oophorectomy unilateral 39.09 9.61 38 545446 930 90082033
Transplant rejection 38.97 9.61 14 545470 12744 90070219
Progressive multifocal leukoencephalopathy 38.80 9.61 23 545461 15632 90067331
Choking sensation 38.56 9.61 78 545406 3864 90079099
Pneumocystis jirovecii pneumonia 38.41 9.61 44 545440 21572 90061391
Hypertransaminasaemia 38.17 9.61 24 545460 15801 90067162
Disseminated intravascular coagulation 38.10 9.61 44 545440 21494 90061469
Hypercapnia 37.97 9.61 107 545377 6570 90076393
Myotonia 37.89 9.61 20 545464 175 90082788
Skin necrosis 37.78 9.61 28 545456 16913 90066050
Femur fracture 37.69 9.61 146 545338 45936 90037027
Dislocation of vertebra 37.51 9.61 191 545293 55777 90027186
Status epilepticus 37.40 9.61 35 545449 18839 90064124
Myocardial infarction 37.33 9.61 868 544616 105104 89977859
Pustular psoriasis 37.26 9.61 34 545450 18522 90064441
General symptom 37.13 9.61 21 545463 14647 90068316
Infusion site swelling 36.78 9.61 154 545330 11566 90071397
Rebound nasal congestion 36.78 9.61 13 545471 35 90082928
Cerebral infarction 36.50 9.61 65 545419 26531 90056432
Vision blurred 36.30 9.61 895 544589 109398 89973565
Stress cardiomyopathy 36.23 9.61 168 545316 13187 90069776
Diabetes mellitus 36.12 9.61 570 544914 64305 90018658
Suspected suicide 35.84 9.61 7 545477 9561 90073402
Interstitial lung disease 35.73 9.61 291 545193 76114 90006849
Infusion site erythema 35.65 9.61 170 545314 13500 90069463
Urticaria 35.53 9.61 2259 543225 310475 89772488
Pulmonary fibrosis 35.50 9.61 445 545039 107058 89975905
Cerebral haemorrhage 35.40 9.61 99 545385 34423 90048540
Drug level increased 35.34 9.61 71 545413 27691 90055272
Malignant mediastinal neoplasm 35.31 9.61 43 545441 1365 90081598
Idiopathic intracranial hypertension 35.20 9.61 71 545413 3510 90079453
Infection 35.07 9.61 1801 543683 360293 89722670
Nephrectomy 35.04 9.61 51 545433 1930 90081033
Blood lactate dehydrogenase increased 35.03 9.61 64 545420 25868 90057095
Contusion 34.77 9.61 1200 544284 250016 89832947
Skin laceration 34.71 9.61 272 545212 25763 90057200
Polymyalgia rheumatica 34.66 9.61 86 545398 4891 90078072
FEV1/FVC ratio decreased 34.54 9.61 18 545466 153 90082810
Osteonecrosis of jaw 34.54 9.61 120 545364 38983 90043980
Blood calcium increased 34.44 9.61 154 545330 11904 90071059
Breast cancer stage II 34.29 9.61 104 545380 35230 90047733
Bacterial infection 34.10 9.61 250 545234 23194 90059769
Skin candida 34.02 9.61 47 545437 1694 90081269
Joint destruction 33.67 9.61 19 545465 13268 90069695
Occupational asthma 33.58 9.61 18 545466 163 90082800
Hyposmia 33.55 9.61 35 545449 934 90082029
Embolism venous 33.49 9.61 70 545414 3550 90079413
Dyspepsia 33.42 9.61 922 544562 197238 89885725
Pneumonia haemophilus 33.08 9.61 43 545441 1460 90081503
Obstruction 33.04 9.61 73 545411 3848 90079115
Nasal septum deviation 32.90 9.61 49 545435 1894 90081069
Adverse drug reaction 32.84 9.61 499 544985 116202 89966761
Sinus tachycardia 32.73 9.61 288 545196 28225 90054738
Overlap syndrome 32.56 9.61 6 545478 8542 90074421
Aspiration 32.49 9.61 183 545301 15510 90067453
Sputum abnormal 32.31 9.61 31 545453 746 90082217
Airway remodelling 32.22 9.61 14 545470 75 90082888
Hypoalbuminaemia 32.07 9.61 29 545455 15868 90067095
Ventricular failure 32.05 9.61 23 545461 363 90082600
Subcutaneous drug absorption impaired 32.05 9.61 21 545463 13524 90069439
Pulmonary hypertension 31.93 9.61 394 545090 42129 90040834
Retching 31.81 9.61 211 545273 18948 90064015
Hypoacusis 31.81 9.61 281 545203 27569 90055394
Polyneuropathy 31.60 9.61 42 545442 19299 90063664
Aspirin-exacerbated respiratory disease 31.51 9.61 29 545455 661 90082302
Wound secretion 31.41 9.61 83 545401 4907 90078056
Hereditary angioedema 30.93 9.61 125 545359 9240 90073723
Joint stiffness 30.92 9.61 310 545174 77732 90005231
Bronchitis bacterial 30.92 9.61 34 545450 965 90081998
Product administration interrupted 30.89 9.61 153 545331 12339 90070624
Tongue biting 30.82 9.61 50 545434 2083 90080880
Device expulsion 30.65 9.61 134 545350 40752 90042211
Colitis 30.63 9.61 271 545213 69671 90013292
Joint dislocation 30.53 9.61 151 545333 44431 90038532
Skin discomfort 30.48 9.61 47 545437 1874 90081089
Lymphopenia 30.44 9.61 57 545427 22824 90060139
Neuropathy peripheral 30.41 9.61 611 544873 136359 89946604
Influenza like illness 30.18 9.61 666 544818 79945 90003018
Chronic respiratory failure 30.17 9.61 57 545427 2684 90080279
Intentional self-injury 30.17 9.61 84 545400 29250 90053713
Pregnancy 30.08 9.61 234 545250 61813 90021150
Pharyngitis streptococcal 30.06 9.61 154 545330 12588 90070375
Rubber sensitivity 30.00 9.61 58 545426 2779 90080184
Pre-existing condition improved 29.97 9.61 122 545362 9047 90073916
Distal intestinal obstruction syndrome 29.95 9.61 25 545459 498 90082465
Sleep terror 29.89 9.61 76 545408 4388 90078575
Painful respiration 29.86 9.61 60 545424 2958 90080005
Depressed level of consciousness 29.72 9.61 609 544875 72175 90010788
Gastrointestinal toxicity 29.58 9.61 10 545474 9457 90073506
Broncholithiasis 29.48 9.61 20 545464 287 90082676
Nausea 29.35 9.61 6070 539414 1104246 88978717
Nervousness 29.33 9.61 324 545160 33732 90049231
Ventilation perfusion mismatch 29.24 9.61 26 545458 566 90082397
Febrile bone marrow aplasia 29.21 9.61 11 545473 9727 90073236
Fall 29.21 9.61 3320 542164 478490 89604473
Rash maculo-papular 28.98 9.61 137 545347 40796 90042167
Bronchitis chronic 28.95 9.61 78 545406 4665 90078298
Pulmonary oedema 28.94 9.61 530 544954 61550 90021413
Eye swelling 28.81 9.61 287 545197 29099 90053864
Anuria 28.75 9.61 28 545456 14790 90068173
Rib deformity 28.71 9.61 19 545465 261 90082702
Encephalopathy 28.63 9.61 163 545321 46281 90036682
Respiratory tract irritation 28.63 9.61 24 545460 481 90082482
Rectal prolapse 28.58 9.61 50 545434 2217 90080746
Personality disorder 28.49 9.61 20 545464 12424 90070539
Infusion site reaction 28.48 9.61 44 545440 18995 90063968
Spondylitis 28.44 9.61 26 545458 14152 90068811
Endometrial ablation 28.40 9.61 33 545451 996 90081967
Aggression 28.38 9.61 265 545219 26403 90056560
Nocturnal dyspnoea 28.33 9.61 39 545445 1401 90081562
Diabetes mellitus inadequate control 28.19 9.61 201 545283 18483 90064480
Ear discomfort 28.18 9.61 129 545355 10071 90072892
Poisoning 28.11 9.61 30 545454 15187 90067776
Delirium 28.08 9.61 450 545034 103909 89979054
Gamma-glutamyltransferase increased 28.08 9.61 125 545359 37827 90045136
Haemophagocytic lymphohistiocytosis 27.98 9.61 31 545453 15428 90067535
Eosinophilic oesophagitis 27.86 9.61 30 545454 831 90082132
Insomnia 27.85 9.61 2350 543134 331124 89751839
Device use issue 27.82 9.61 66 545418 3647 90079316
Wound complication 27.75 9.61 77 545407 4686 90078277
Coordination abnormal 27.71 9.61 54 545430 21302 90061661
Oesophageal spasm 27.67 9.61 62 545422 3299 90079664
Uveitis 27.58 9.61 33 545451 15870 90067093
Crepitations 27.54 9.61 116 545368 8736 90074227
Expired product administered 27.49 9.61 98 545386 6824 90076139
Cytomegalovirus viraemia 27.48 9.61 6 545478 7580 90075383
Lymph node calcification 27.36 9.61 21 545463 369 90082594
Nasal inflammation 27.30 9.61 27 545457 675 90082288
Terminal insomnia 27.11 9.61 35 545449 1180 90081783
Bronchomalacia 27.09 9.61 17 545467 212 90082751
Toxic skin eruption 27.07 9.61 33 545451 15741 90067222
Adjustment disorder with depressed mood 27.07 9.61 215 545269 56538 90026425
Hypercalcaemia 27.04 9.61 110 545374 34130 90048833
Magnetic resonance imaging thoracic abnormal 26.97 9.61 9 545475 19 90082944
Forced expiratory volume increased 26.93 9.61 12 545472 69 90082894
Nonspecific reaction 26.79 9.61 55 545429 2754 90080209
Mood altered 26.78 9.61 186 545298 16958 90066005
Metastases to central nervous system 26.76 9.61 40 545444 17502 90065461
Respiratory tract infection viral 26.49 9.61 58 545426 3038 90079925
Nasal disorder 26.29 9.61 60 545424 3232 90079731
Ischaemic stroke 26.28 9.61 59 545425 22107 90060856
Drug tolerance decreased 26.14 9.61 102 545382 32028 90050935
Bronchiolitis 25.95 9.61 61 545423 3351 90079612
Tracheomalacia 25.80 9.61 20 545464 357 90082606
Mixed liver injury 25.72 9.61 7 545477 7616 90075347
Atelectasis 25.70 9.61 242 545242 24167 90058796
Venoocclusive liver disease 25.61 9.61 3 545481 5990 90076973
Oxygen consumption increased 25.57 9.61 73 545411 4516 90078447
Breast cancer stage I 25.50 9.61 13 545471 9611 90073352
Feeling cold 25.38 9.61 265 545219 27200 90055763
Dermatitis allergic 25.34 9.61 185 545299 17142 90065821
Skin toxicity 25.31 9.61 5 545479 6774 90076189
Nightmare 25.23 9.61 220 545264 21505 90061458
Increased viscosity of upper respiratory secretion 25.18 9.61 17 545467 242 90082721
Sinus congestion 25.05 9.61 264 545220 27160 90055803
Sinonasal obstruction 24.94 9.61 17 545467 246 90082717
Pharyngeal oedema 24.91 9.61 155 545329 13616 90069347
Ovarian hyperstimulation syndrome 24.89 9.61 3 545481 5859 90077104
Scoliosis 24.87 9.61 113 545371 8794 90074169
Essential hypertension 24.73 9.61 89 545395 6226 90076737
Circumstance or information capable of leading to device use error 24.54 9.61 16 545468 214 90082749
Epstein-Barr virus infection 24.52 9.61 16 545468 10328 90072635
Proteinuria 24.47 9.61 66 545418 23225 90059738
Tympanosclerosis 24.44 9.61 11 545473 65 90082898
Pulmonary pain 24.39 9.61 77 545407 5037 90077926
Musculoskeletal chest pain 24.28 9.61 234 545250 23516 90059447
Snoring 24.28 9.61 77 545407 5049 90077914
Rash macular 24.24 9.61 284 545200 29996 90052967
Extra dose administered 24.22 9.61 114 545370 9004 90073959
Pneumonia respiratory syncytial viral 24.22 9.61 35 545449 1316 90081647
Wrong technique in product usage process 24.21 9.61 583 544901 70988 90011975
Intentional device misuse 24.18 9.61 28 545456 842 90082121
Insurance issue 24.17 9.61 130 545354 10828 90072135
Bradycardia 24.11 9.61 357 545127 83490 89999473
Drug use disorder 24.08 9.61 10 545474 8333 90074630
Renal failure 24.07 9.61 602 544882 130405 89952558
Nasal pruritus 24.04 9.61 26 545458 724 90082239
Intervertebral disc protrusion 24.00 9.61 260 545224 26936 90056027
Crying 23.96 9.61 248 545236 25397 90057566
Diffuse large B-cell lymphoma 23.94 9.61 11 545473 8634 90074329
Cockroach allergy 23.90 9.61 11 545473 69 90082894
Enterocolitis 23.83 9.61 17 545467 10473 90072490
Lupus-like syndrome 23.78 9.61 184 545300 48662 90034301
Anti-cyclic citrullinated peptide antibody 23.73 9.61 84 545400 27137 90055826
Hypervolaemia 23.52 9.61 301 545183 32456 90050507
CFTR gene mutation 23.39 9.61 16 545468 233 90082730
Stress urinary incontinence 23.37 9.61 48 545436 2404 90080559
Pulmonary toxicity 23.30 9.61 21 545463 11510 90071453
Therapeutic response shortened 23.18 9.61 225 545259 22654 90060309
Carbon dioxide increased 23.18 9.61 41 545443 1834 90081129
Pollakiuria 23.16 9.61 302 545182 32703 90050260
Myopathy 23.12 9.61 150 545334 13368 90069595
Neutrophilia 23.12 9.61 82 545402 5696 90077267
Hypertensive crisis 23.05 9.61 45 545439 17739 90065224
Enthesopathy 23.05 9.61 14 545470 9390 90073573
Device defective 22.98 9.61 59 545425 3427 90079536
Tuberculosis 22.89 9.61 25 545459 12524 90070439
Congenital cardiovascular anomaly 22.88 9.61 21 545463 477 90082486
Candida infection 22.81 9.61 309 545175 33748 90049215
Ulcer 22.73 9.61 111 545373 32771 90050192
Fungal infection 22.69 9.61 372 545112 42289 90040674
Truncus arteriosus persistent 22.62 9.61 19 545465 382 90082581
Device ineffective 22.54 9.61 16 545468 248 90082715
Heart sounds 22.53 9.61 31 545453 1113 90081850
Deformity 22.47 9.61 24 545460 12146 90070817
Infusion site pain 22.46 9.61 199 545285 19539 90063424
Tricuspid valve incompetence 22.42 9.61 175 545309 16556 90066407
Body temperature abnormal 22.39 9.61 49 545435 2566 90080397
Hypocalcaemia 22.35 9.61 156 545328 42212 90040751
Metastases to lung 22.02 9.61 39 545445 15952 90067011
Pneumococcal infection 21.95 9.61 32 545452 1213 90081750
Self-injurious ideation 21.94 9.61 55 545429 3148 90079815
Upper airway obstruction 21.90 9.61 29 545455 1003 90081960
SARS-CoV-2 test positive 21.88 9.61 128 545356 11000 90071963
Drug delivery system issue 21.87 9.61 13 545471 146 90082817
Generalised anxiety disorder 21.87 9.61 50 545434 2697 90080266
Oropharyngitis fungal 21.82 9.61 10 545474 62 90082901
Wrist fracture 21.81 9.61 165 545319 15459 90067504
Drug tolerance 21.81 9.61 47 545437 17869 90065094
Basal cell carcinoma 21.78 9.61 115 545369 33274 90049689
Separation anxiety disorder 21.77 9.61 8 545476 25 90082938
Functional residual capacity increased 21.67 9.61 11 545473 88 90082875
Fatigue 21.66 9.61 6408 539076 1147615 88935348
Metastases to lymph nodes 21.64 9.61 23 545461 11666 90071297
Diarrhoea 21.55 9.61 5169 540315 934021 89148942
Bone density decreased 21.53 9.61 45 545439 17300 90065663
Anhedonia 21.53 9.61 130 545354 11301 90071662
Tension headache 21.52 9.61 96 545388 7413 90075550
Body mass index increased 21.51 9.61 35 545449 1462 90081501
Oropharyngeal discomfort 21.50 9.61 98 545386 7637 90075326
Blood immunoglobulin E decreased 21.43 9.61 14 545470 188 90082775
Eye irritation 21.43 9.61 305 545179 33673 90049290
Venous pressure jugular increased 21.37 9.61 22 545462 578 90082385
Pyrexia 21.24 9.61 3573 541911 656912 89426051
Peripheral sensory neuropathy 21.00 9.61 15 545469 9235 90073728
Gangrene 21.00 9.61 28 545456 12848 90070115
Asthma exercise induced 20.86 9.61 20 545464 481 90082482
Hemiplegia 20.85 9.61 41 545443 16119 90066844
Gallbladder injury 20.79 9.61 32 545452 1274 90081689
Spinal fusion surgery 20.76 9.61 26 545458 12257 90070706
Muscle tension dysphonia 20.76 9.61 16 545468 283 90082680
Secondary immunodeficiency 20.72 9.61 42 545442 2084 90080879
Bradyphrenia 20.60 9.61 10 545474 7602 90075361
Bronchoscopy 20.58 9.61 10 545474 72 90082891
Cervix neoplasm 20.57 9.61 14 545470 202 90082761
Schizophrenia 20.54 9.61 157 545327 14757 90068206
Aplastic anaemia 20.49 9.61 30 545454 13239 90069724
Vocal cord disorder 20.44 9.61 35 545449 1525 90081438
Scratch 20.39 9.61 115 545369 9751 90073212
Paranasal sinus hypersecretion 20.32 9.61 67 545417 4484 90078479
Endometriosis 20.32 9.61 83 545401 6165 90076798
Hyperprolactinaemia 20.30 9.61 4 545480 5429 90077534
Pulmonary thrombosis 20.21 9.61 114 545370 9668 90073295
Generalised tonic-clonic seizure 20.19 9.61 125 545359 34778 90048185
Graft versus host disease 20.13 9.61 12 545472 8132 90074831
Amniotic fluid index increased 20.12 9.61 11 545473 104 90082859
Blood insulin abnormal 20.08 9.61 8 545476 33 90082930
Death 19.99 9.61 2424 543060 454127 89628836
Oesophageal dilatation 19.94 9.61 20 545464 509 90082454
Appetite disorder 19.91 9.61 108 545376 9025 90073938
Oedema peripheral 19.89 9.61 1807 543677 256108 89826855
Thunderclap headache 19.86 9.61 17 545467 351 90082612
Mouth swelling 19.85 9.61 77 545407 5585 90077378
Foreign body aspiration 19.83 9.61 14 545470 215 90082748
Vaginal discharge 19.82 9.61 56 545428 19408 90063555
Respiratory acidosis 19.77 9.61 99 545385 8020 90074943
Hepatic cirrhosis 19.71 9.61 265 545219 62988 90019975
Lung consolidation 19.63 9.61 69 545415 4771 90078192
Walking aid user 19.60 9.61 129 545355 35377 90047586
Rash vesicular 19.55 9.61 51 545433 18146 90064817
Haemolytic anaemia 19.52 9.61 25 545459 11672 90071291
Product administration error 19.48 9.61 244 545240 26179 90056784
Exposure to toxic agent 19.33 9.61 12 545472 7955 90075008
Tobacco abuse 19.26 9.61 23 545461 715 90082248
Underdose 19.21 9.61 220 545264 53797 90029166
Pneumothorax spontaneous 19.20 9.61 26 545458 919 90082044
Infusion site bruising 19.20 9.61 64 545420 4308 90078655
Pneumothorax 19.18 9.61 188 545296 18979 90063984
Creatinine renal clearance increased 19.07 9.61 53 545431 3228 90079735
Increased viscosity of bronchial secretion 19.01 9.61 17 545467 373 90082590
Medication error 18.97 9.61 377 545107 84275 89998688
Concussion 18.93 9.61 123 545361 10968 90071995
Atopy 18.92 9.61 15 545469 277 90082686
Injection site swelling 18.92 9.61 483 545001 59356 90023607
Small airways disease 18.89 9.61 6 545478 10 90082953
Urosepsis 18.86 9.61 65 545419 21167 90061796
Decreased bronchial secretion 18.85 9.61 9 545475 62 90082901
Nystagmus 18.80 9.61 10 545474 7217 90075746
Mental disorder 18.77 9.61 286 545198 32032 90050931
Supraventricular tachycardia 18.74 9.61 165 545319 16171 90066792
Hilar lymphadenopathy 18.67 9.61 31 545453 1317 90081646
Pathogen resistance 18.64 9.61 13 545471 8102 90074861
Renal disorder 18.63 9.61 326 545158 37533 90045430
Brain oedema 18.47 9.61 49 545435 17336 90065627
Allergic cough 18.46 9.61 28 545456 1100 90081863
Sinus polyp degeneration 18.39 9.61 9 545475 66 90082897
Red blood cell sedimentation rate abnormal 18.34 9.61 79 545405 24125 90058838
Hyperbilirubinaemia 18.29 9.61 35 545449 13901 90069062
Hepatic failure 18.26 9.61 152 545332 39576 90043387
Klebsiella infection 18.25 9.61 21 545463 10276 90072687
Tracheobronchitis bacterial 18.19 9.61 6 545478 12 90082951
Coronary artery disease 18.18 9.61 294 545190 33329 90049634
Oxygen saturation abnormal 18.15 9.61 62 545422 4226 90078737
Ulcer haemorrhage 18.11 9.61 89 545395 26232 90056731
Functional residual capacity decreased 18.05 9.61 9 545475 69 90082894
Extrapyramidal disorder 18.05 9.61 45 545439 16258 90066705
Fracture 18.01 9.61 70 545414 22006 90060957
Neck injury 17.98 9.61 43 545441 2389 90080574
Left ventricular failure 17.97 9.61 84 545400 6616 90076347
Labelled drug-drug interaction medication error 17.96 9.61 38 545446 14544 90068419
Tongue pruritus 17.94 9.61 23 545461 770 90082193
Kyphosis 17.93 9.61 48 545436 2860 90080103
Oxygen therapy 17.93 9.61 50 545434 3052 90079911
PCO2 increased 17.92 9.61 30 545454 1283 90081680
Peak expiratory flow rate abnormal 17.90 9.61 10 545474 99 90082864
Pneumonia pseudomonal 17.89 9.61 51 545433 3152 90079811
Eye allergy 17.89 9.61 30 545454 1285 90081678
Paraesthesia 17.86 9.61 1281 544203 249045 89833918
Paranoia 17.84 9.61 136 545348 12772 90070191
Immune reconstitution inflammatory syndrome 17.84 9.61 10 545474 7009 90075954
Adjustment disorder 17.82 9.61 19 545465 9623 90073340
Eosinophil count decreased 17.81 9.61 51 545433 3161 90079802
Pneumonia aspiration 17.76 9.61 159 545325 40781 90042182
Female genital tract fistula 17.76 9.61 52 545432 17816 90065147
Hysterectomy 17.70 9.61 125 545359 11459 90071504
Neurosensory hypoacusis 17.65 9.61 13 545471 214 90082749
Intentional dose omission 17.59 9.61 174 545310 17609 90065354
Ischaemic contracture of the left ventricle 17.54 9.61 11 545473 137 90082826
Myositis 17.53 9.61 80 545404 24048 90058915
Oral pruritus 17.48 9.61 48 545436 2903 90080060
BK virus infection 17.47 9.61 3 545481 4495 90078468
Cholecystectomy 17.47 9.61 126 545358 11629 90071334
Eosinophilic pneumonia chronic 17.45 9.61 13 545471 218 90082745
Blood pressure abnormal 17.42 9.61 188 545296 19457 90063506
Breast conserving surgery 17.42 9.61 28 545456 1157 90081806
Hemiparesis 17.36 9.61 116 545368 31703 90051260
Vasculitis 17.36 9.61 211 545273 22482 90060481
Suspected COVID-19 17.23 9.61 45 545439 2641 90080322
Sinus headache 17.23 9.61 81 545403 6395 90076568
Scleritis 17.17 9.61 5 545479 5203 90077760
Post-traumatic stress disorder 17.15 9.61 84 545400 6744 90076219
Aplasia pure red cell 17.10 9.61 5 545479 5189 90077774
Duodenal ulcer repair 17.02 9.61 8 545476 53 90082910
Initial insomnia 16.98 9.61 105 545379 9205 90073758
Somnolence 16.92 9.61 1058 544426 208026 89874937
Breast cancer recurrent 16.87 9.61 6 545478 5497 90077466
Diastolic dysfunction 16.86 9.61 88 545396 7245 90075718
Peripheral vascular disorder 16.79 9.61 80 545404 6351 90076612
Ascites 16.75 9.61 195 545289 47545 90035418
Aphthous ulcer 16.69 9.61 51 545433 17236 90065727
Dyspnoea at rest 16.67 9.61 65 545419 4726 90078237
Cardiac septal defect 16.57 9.61 22 545462 763 90082200
Symptom recurrence 16.54 9.61 57 545427 3902 90079061
Dyspnoea paroxysmal nocturnal 16.54 9.61 26 545458 1054 90081909
Crystal arthropathy 16.51 9.61 15 545469 336 90082627
Radioallergosorbent test positive 16.50 9.61 7 545477 35 90082928
Alanine aminotransferase abnormal 16.49 9.61 6 545478 5420 90077543
Cardiac arrest 16.48 9.61 493 544991 104442 89978521
Breath alcohol test positive 16.48 9.61 4 545480 0 90082963
Pemphigoid 16.44 9.61 18 545466 9008 90073955
Soft tissue disorder 16.36 9.61 3 545481 4287 90078676
Nephrolithiasis 16.35 9.61 399 545085 48686 90034277
Blood cholesterol decreased 16.32 9.61 36 545448 1895 90081068
Gastroenteritis viral 16.25 9.61 265 545219 30090 90052873
Ageusia 16.24 9.61 158 545326 15918 90067045
Tongue injury 16.24 9.61 19 545465 578 90082385
Weight increased 16.21 9.61 2236 543248 415691 89667272
Radiculopathy 16.20 9.61 57 545427 18448 90064515
Incorrect dose administered by device 16.18 9.61 73 545411 5664 90077299
Nasal mucosal disorder 16.13 9.61 35 545449 1822 90081141
Red cell distribution width abnormal 16.12 9.61 12 545472 201 90082762
Pharyngeal erythema 16.07 9.61 35 545449 1827 90081136
Vaccination site haemorrhage 16.04 9.61 7 545477 38 90082925
Bacterial tracheitis 16.04 9.61 6 545478 20 90082943
Weight decreased 16.02 9.61 2562 542922 377348 89705615
Lip discolouration 15.94 9.61 20 545464 655 90082308
Haemorrhage intracranial 15.90 9.61 43 545441 15119 90067844
Swelling of eyelid 15.84 9.61 70 545414 5384 90077579
Acute sinusitis 15.80 9.61 59 545425 4202 90078761
Hyperlipidaemia 15.79 9.61 209 545275 22707 90060256
Fibromuscular dysplasia 15.77 9.61 14 545470 304 90082659
Pneumonia viral 15.77 9.61 99 545385 8724 90074239
Complication of device removal 15.75 9.61 77 545407 6178 90076785
Polyarthritis 15.75 9.61 57 545427 18293 90064670
Skin fissures 15.71 9.61 193 545291 20616 90062347
Hepatitis cholestatic 15.68 9.61 17 545467 8544 90074419
Dermatitis exfoliative generalised 15.67 9.61 7 545477 5586 90077377
Upper respiratory tract congestion 15.60 9.61 40 545444 2322 90080641
Chronic graft versus host disease 15.56 9.61 3 545481 4136 90078827
Chronic sinusitis 15.55 9.61 215 545269 23587 90059376
Purpura 15.43 9.61 42 545442 14736 90068227
Infusion site pruritus 15.43 9.61 81 545403 6684 90076279
Central obesity 15.42 9.61 29 545455 1361 90081602
Mycobacterium avium complex infection 15.41 9.61 57 545427 4041 90078922
Laryngeal pain 15.39 9.61 60 545424 4362 90078601
Infusion site haemorrhage 15.37 9.61 69 545415 5342 90077621
Gout 15.26 9.61 162 545322 16697 90066266
Accidental exposure to product 15.22 9.61 348 545136 42018 90040945
Pickwickian syndrome 15.17 9.61 15 545469 375 90082588
PO2 decreased 15.13 9.61 31 545453 1550 90081413
Biliary dyskinesia 15.13 9.61 42 545442 2557 90080406
Psychomotor retardation 15.07 9.61 5 545479 4784 90078179
Lupus vulgaris 15.07 9.61 186 545298 44873 90038090
Grip strength 15.04 9.61 99 545385 8866 90074097
X-ray abnormal 15.00 9.61 188 545296 45236 90037727
Ankle fracture 14.97 9.61 188 545296 20182 90062781
Exposure during pregnancy 14.97 9.61 1233 544251 237177 89845786
Sensory loss 14.95 9.61 57 545427 18018 90064945
Uterine perforation 14.93 9.61 87 545397 7467 90075496
Affect lability 14.92 9.61 57 545427 18006 90064957
Overweight 14.90 9.61 73 545411 5861 90077102
Carcinoid tumour pulmonary 14.90 9.61 17 545467 503 90082460
Dysuria 14.89 9.61 326 545158 39075 90043888
Graft versus host disease in gastrointestinal tract 14.86 9.61 4 545480 4384 90078579
Sense of oppression 14.84 9.61 25 545459 1075 90081888
Ileus paralytic 14.83 9.61 6 545478 5079 90077884
Peripheral circulatory failure 14.82 9.61 31 545453 1573 90081390
Cor pulmonale 14.77 9.61 36 545448 2024 90080939
Influenza B virus test positive 14.77 9.61 13 545471 279 90082684
Musculoskeletal disorder 14.75 9.61 74 545410 21695 90061268
Body temperature decreased 14.71 9.61 213 545271 23603 90059360
Platelet count increased 14.69 9.61 191 545293 20668 90062295
Vomiting 14.67 9.61 4378 541106 783915 89299048
Akathisia 14.67 9.61 28 545456 11131 90071832
Haematochezia 14.66 9.61 320 545164 70593 90012370
Injection site vesicles 14.63 9.61 57 545427 4143 90078820
Neuroglycopenia 14.59 9.61 25 545459 1090 90081873
Trifascicular block 14.57 9.61 9 545475 109 90082854
Joint effusion 14.53 9.61 65 545419 19645 90063318
Ligament sprain 14.51 9.61 143 545341 14456 90068507
Postural orthostatic tachycardia syndrome 14.51 9.61 38 545446 2234 90080729
Ear infection 14.50 9.61 535 544949 69240 90013723
Poor quality product administered 14.45 9.61 55 545429 3953 90079010
Product availability issue 14.45 9.61 85 545399 7319 90075644
Infective exacerbation of bronchiectasis 14.44 9.61 16 545468 458 90082505
Transient ischaemic attack 14.39 9.61 351 545133 42825 90040138
Infusion site mass 14.38 9.61 37 545447 2152 90080811
Sensation of foreign body 14.37 9.61 76 545408 6290 90076673
Angle closure glaucoma 14.37 9.61 43 545441 2732 90080231
Cerebral haematoma 14.36 9.61 4 545480 4285 90078678
Breast cancer metastatic 14.35 9.61 45 545439 15087 90067876
Exostosis 14.33 9.61 229 545255 52905 90030058
Pneumonectomy 14.26 9.61 4 545480 3 90082960
Cerebrovascular arteriovenous malformation 14.25 9.61 8 545476 80 90082883
Colitis ulcerative 14.24 9.61 266 545218 60000 90022963
Drug administered in wrong device 14.22 9.61 7 545477 52 90082911
Use of accessory respiratory muscles 14.19 9.61 14 545470 349 90082614
Calcinosis 14.18 9.61 42 545442 2653 90080310
Deep vein thrombosis 14.16 9.61 681 544803 90939 89992024
Nasal turbinate abnormality 14.14 9.61 6 545478 30 90082933
Oesophageal pain 14.14 9.61 58 545426 4316 90078647
Electrocardiogram QRS complex prolonged 14.12 9.61 14 545470 7334 90075629
Pelvic pain 14.10 9.61 148 545336 15209 90067754
Nephrotic syndrome 14.09 9.61 14 545470 7325 90075638
Impaired work ability 14.09 9.61 64 545420 19262 90063701
Tooth abscess 14.06 9.61 156 545328 16257 90066706
Lung operation 14.06 9.61 14 545470 353 90082610
Graft versus host disease in skin 14.06 9.61 3 545481 3850 90079113
Demyelination 14.00 9.61 17 545467 8123 90074840
Unintentional medical device removal 13.97 9.61 13 545471 7017 90075946
Endocrine ophthalmopathy 13.95 9.61 24 545460 1050 90081913
Burns third degree 13.89 9.61 13 545471 303 90082660
Mucormycosis 13.89 9.61 3 545481 3818 90079145
Nerve compression 13.87 9.61 110 545374 10456 90072507
Colitis microscopic 13.81 9.61 29 545455 11130 90071833
Tumour lysis syndrome 13.79 9.61 29 545455 11123 90071840
Skin ulcer 13.78 9.61 215 545269 49860 90033103
Diastolic hypotension 13.76 9.61 8 545476 86 90082877
Forced expiratory volume 13.75 9.61 5 545479 15 90082948
Diverticulum 13.72 9.61 122 545362 11991 90070972
Laryngeal stenosis 13.70 9.61 27 545457 1312 90081651
Orthopnoea 13.69 9.61 79 545405 6756 90076207
Oliguria 13.67 9.61 27 545457 10597 90072366
Affective disorder 13.65 9.61 87 545397 7706 90075257
Dysmenorrhoea 13.59 9.61 60 545424 4612 90078351
Cystic fibrosis related diabetes 13.58 9.61 7 545477 58 90082905
Oxygen consumption decreased 13.58 9.61 13 545471 312 90082651
Injection site urticaria 13.57 9.61 167 545317 17844 90065119
Neuroleptic malignant syndrome 13.55 9.61 46 545438 15050 90067913
Sensitive skin 13.54 9.61 48 545436 3333 90079630
Stridor 13.53 9.61 61 545423 4732 90078231
Acute respiratory distress syndrome 13.53 9.61 109 545375 28577 90054386
Catatonia 13.52 9.61 10 545474 6046 90076917
Coeliac disease 13.50 9.61 358 545126 44252 90038711
Mucosal discolouration 13.49 9.61 18 545466 627 90082336
Erysipelas 13.46 9.61 21 545463 9031 90073932
Anger 13.45 9.61 134 545350 13586 90069377
Infusion site urticaria 13.41 9.61 31 545453 1684 90081279
Arthritis bacterial 13.40 9.61 15 545469 7430 90075533
Quarantine 13.39 9.61 6 545478 35 90082928
Total lung capacity abnormal 13.37 9.61 8 545476 91 90082872
Local reaction 13.37 9.61 20 545464 776 90082187
Glaucoma 13.37 9.61 187 545297 20568 90062395
Hypoglobulinaemia 13.36 9.61 10 545474 169 90082794
Atrial fibrillation 13.35 9.61 955 544529 132656 89950307
Premature delivery 13.34 9.61 159 545325 38603 90044360
Disability 13.32 9.61 169 545315 40576 90042387
Nasal flaring 13.29 9.61 5 545479 17 90082946
Sputum culture 13.28 9.61 13 545471 321 90082642
Hyperpyrexia 13.28 9.61 6 545478 4755 90078208
Vitamin D decreased 13.23 9.61 120 545364 11859 90071104
Postoperative renal failure 13.22 9.61 9 545475 130 90082833
Dependence on oxygen therapy 13.13 9.61 17 545467 575 90082388
Red blood cell count decreased 13.10 9.61 198 545286 46153 90036810
Facial discomfort 13.08 9.61 13 545471 327 90082636
Micturition disorder 13.08 9.61 44 545440 2976 90079987
Oesophagogastroduodenoscopy 13.06 9.61 10 545474 175 90082788
Hallucination 13.05 9.61 503 544981 65456 90017507
Renal function test abnormal 13.05 9.61 81 545403 7110 90075853
Lipohypertrophy 13.04 9.61 19 545465 720 90082243
Autoimmune haemolytic anaemia 13.02 9.61 9 545475 5636 90077327
Neuromyotonia 13 9.61 7 545477 64 90082899
Varicella zoster gastritis 12.99 9.61 6 545478 38 90082925
Female reproductive neoplasm 12.99 9.61 6 545478 38 90082925
Hypothermia 12.96 9.61 49 545435 15526 90067437
Blood urine present 12.93 9.61 160 545324 17118 90065845
Tachypnoea 12.93 9.61 190 545294 21119 90061844
Product label issue 12.92 9.61 22 545462 954 90082009
Immunosuppressant drug level increased 12.89 9.61 6 545478 4674 90078289
Tympanoplasty 12.87 9.61 5 545479 19 90082944
Hyperammonaemia 12.84 9.61 12 545472 6463 90076500
Inspiratory capacity decreased 12.82 9.61 7 545477 66 90082897
Complication of device insertion 12.81 9.61 107 545377 10329 90072634
Lactose intolerance 12.79 9.61 47 545437 3322 90079641
Ventricular arrhythmia 12.76 9.61 5 545479 4316 90078647
Obstructive pancreatitis 12.73 9.61 18 545466 663 90082300
Cardiac failure 12.71 9.61 534 544950 108962 89974001
Dysphemia 12.65 9.61 44 545440 3026 90079937
Arteriosclerosis coronary artery 12.62 9.61 100 545384 9503 90073460
Disorientation 12.62 9.61 188 545296 43926 90039037
Metastasis 12.61 9.61 11 545473 6126 90076837
Presyncope 12.61 9.61 265 545219 31540 90051423
Respiratory arrest 12.50 9.61 134 545350 33177 90049786
Granuloma annulare 12.49 9.61 20 545464 824 90082139
Paronychia 12.46 9.61 18 545466 7988 90074975
Laryngitis fungal 12.42 9.61 10 545474 189 90082774
Ataxia 12.41 9.61 61 545423 17981 90064982
Sinus polyp 12.41 9.61 14 545470 409 90082554
Pelvic kidney 12.40 9.61 8 545476 105 90082858
Retinitis 12.39 9.61 160 545324 38298 90044665
Adrenal suppression 12.39 9.61 22 545462 987 90081976
Urticaria pressure 12.38 9.61 7 545477 71 90082892
Non-cardiac chest pain 12.38 9.61 76 545408 6645 90076318
Weight 12.36 9.61 3 545481 0 90082963
Alcohol test false positive 12.36 9.61 3 545481 0 90082963
Asthma prophylaxis 12.36 9.61 3 545481 0 90082963
Noninfective bronchitis 12.36 9.61 3 545481 0 90082963
Diffuse large B-cell lymphoma recurrent 12.35 9.61 3 545481 3523 90079440
Anosognosia 12.33 9.61 3 545481 3519 90079444
Gingival bleeding 12.32 9.61 47 545437 14856 90068107
Congenital anomaly 12.31 9.61 12 545472 6335 90076628
Respiratory syncytial virus bronchiolitis 12.30 9.61 14 545470 413 90082550
Sleep disorder 12.30 9.61 1025 544459 197005 89885958
Upper airway resistance syndrome 12.30 9.61 5 545479 22 90082941
Poor quality sleep 12.28 9.61 213 545271 24480 90058483
Breast cancer female 12.28 9.61 47 545437 14839 90068124
Immune effector cell-associated neurotoxicity syndrome 12.27 9.61 10 545474 5758 90077205
Cerebellar syndrome 12.26 9.61 4 545480 3868 90079095
Cholelithiasis 12.25 9.61 408 545076 52098 90030865
Infusion site extravasation 12.21 9.61 105 545379 10223 90072740
Toxic encephalopathy 12.17 9.61 21 545463 8678 90074285
Schizoaffective disorder 12.15 9.61 8 545476 5139 90077824
White coat hypertension 12.14 9.61 22 545462 1003 90081960
Drug effective for unapproved indication 12.13 9.61 18 545466 7900 90075063
Foetal macrosomia 12.13 9.61 11 545473 246 90082717
Clubbing 12.10 9.61 15 545469 485 90082478
Wrong patient received product 12.10 9.61 3 545481 3474 90079489
Excessive eye blinking 12.08 9.61 26 545458 1346 90081617
Dizziness 12.03 9.61 3842 541642 585442 89497521
Periorbital swelling 12.03 9.61 59 545425 4739 90078224
Multiple sclerosis relapse 12.01 9.61 232 545252 52073 90030890
Cytopenia 12.00 9.61 59 545425 17390 90065573
Chloasma 11.98 9.61 9 545475 153 90082810
Hypomania 11.89 9.61 93 545391 8804 90074159
Blood pressure inadequately controlled 11.86 9.61 71 545413 6153 90076810
Normal newborn 11.85 9.61 87 545397 23275 90059688
Tooth loss 11.83 9.61 82 545402 7472 90075491
Activated partial thromboplastin time 11.82 9.61 4 545480 9 90082954
Post-tussive vomiting 11.82 9.61 4 545480 9 90082954
Jaundice cholestatic 11.82 9.61 102 545382 9941 90073022
Accident 11.79 9.61 77 545407 6877 90076086
Upper limb fracture 11.79 9.61 189 545295 21389 90061574
Abortion spontaneous 11.74 9.61 242 545242 53814 90029149
Hyperventilation 11.72 9.61 75 545409 6653 90076310
Biliary colic 11.69 9.61 52 545432 4011 90078952
Sweating fever 11.67 9.61 7 545477 80 90082883
B-lymphocyte abnormalities 11.66 9.61 11 545473 259 90082704
Vitamin D deficiency 11.64 9.61 159 545325 17397 90065566
Attention deficit hyperactivity disorder 11.62 9.61 53 545431 4131 90078832
Otorrhoea 11.61 9.61 31 545453 1844 90081119
Vaccination site pain 11.57 9.61 13 545471 378 90082585
Granulocytopenia 11.56 9.61 13 545471 6428 90076535
Red blood cell count increased 11.54 9.61 48 545436 3595 90079368
Stab wound 11.53 9.61 7 545477 82 90082881
Decreased immune responsiveness 11.44 9.61 91 545393 8657 90074306
Blood electrolytes abnormal 11.43 9.61 23 545461 1135 90081828
Gastric polyps 11.40 9.61 57 545427 4615 90078348
Tinnitus 11.39 9.61 340 545144 42762 90040201
Carbon dioxide abnormal 11.31 9.61 10 545474 216 90082747
Eye paraesthesia 11.27 9.61 9 545475 168 90082795
Female sterilisation 11.24 9.61 17 545467 666 90082297
Intraocular pressure test 11.22 9.61 6 545478 54 90082909
Inappropriate antidiuretic hormone secretion 11.21 9.61 70 545414 19435 90063528
Cystitis haemorrhagic 11.19 9.61 10 545474 5503 90077460
Peritonitis 11.18 9.61 71 545413 19634 90063329
Aplasia 11.17 9.61 5 545479 3986 90078977
Cachexia 11.17 9.61 15 545469 6863 90076100
Croup infectious 11.17 9.61 17 545467 670 90082293
Nephropathy toxic 11.16 9.61 39 545445 12649 90070314
Arterial occlusive disease 11.12 9.61 38 545446 12408 90070555
Pseudomonal sepsis 11.12 9.61 6 545478 4296 90078667
Dry throat 11.08 9.61 84 545400 7876 90075087
Aneurysm 11.06 9.61 47 545437 3553 90079410
Motor dysfunction 11.05 9.61 69 545415 19161 90063802
Cerumen impaction 11.05 9.61 23 545461 1163 90081800
Enteritis 11.03 9.61 29 545455 10292 90072671
Caesarean section 11.02 9.61 66 545418 18511 90064452
Renal artery angioplasty 11.00 9.61 4 545480 12 90082951
Nodule 10.99 9.61 105 545379 26581 90056382
Neoplasm recurrence 10.98 9.61 3 545481 3256 90079707
Flail chest 10.97 9.61 7 545477 90 90082873
Cystic fibrosis lung 10.95 9.61 8 545476 130 90082833
Memory impairment 10.92 9.61 1030 544454 196214 89886749
Cardiac flutter 10.90 9.61 56 545428 4582 90078381
Vasomotor rhinitis 10.90 9.61 10 545474 227 90082736
Aortic disorder 10.88 9.61 19 545465 841 90082122
Restless legs syndrome 10.88 9.61 193 545291 22277 90060686
Kidney transplant rejection 10.87 9.61 8 545476 4849 90078114
Factitious disorder 10.85 9.61 8 545476 132 90082831
Treatment noncompliance 10.84 9.61 397 545087 51330 90031633
Malignant melanoma 10.83 9.61 39 545445 12537 90070426
Pain 10.83 9.61 5642 539842 990699 89092264
High frequency ablation 10.83 9.61 10 545474 229 90082734
Angioplasty 10.79 9.61 26 545458 1451 90081512
Eosinophilic pneumonia 10.79 9.61 39 545445 2734 90080229
Physiotherapy 10.78 9.61 7 545477 93 90082870
Cystic fibrosis hepatic disease 10.77 9.61 4 545480 13 90082950
Cellulitis 10.76 9.61 662 544822 90675 89992288
Oral mucosal blistering 10.75 9.61 75 545409 6849 90076114
Gastroenteritis bacterial 10.74 9.61 13 545471 410 90082553
Enterococcal infection 10.73 9.61 28 545456 9963 90073000
Wheelchair user 10.71 9.61 19 545465 7766 90075197
Rhabdomyolysis 10.68 9.61 231 545253 51025 90031938
Pleuritic pain 10.66 9.61 103 545381 10358 90072605
Impaired gastric emptying 10.64 9.61 121 545363 12688 90070275
Sexual dysfunction 10.64 9.61 8 545476 4796 90078167
Toxic shock syndrome 10.62 9.61 21 545463 1023 90081940
Oropharyngeal spasm 10.62 9.61 11 545473 291 90082672
Emergency care 10.59 9.61 27 545457 1562 90081401
Jaundice 10.58 9.61 135 545349 32382 90050581
Skin weeping 10.58 9.61 39 545445 2761 90080202
Otitis media 10.58 9.61 66 545418 5804 90077159
Device material issue 10.57 9.61 13 545471 417 90082546
Injection site eczema 10.53 9.61 7 545477 97 90082866
Oropharyngeal candidiasis 10.50 9.61 23 545461 1205 90081758
Haemophilus infection 10.45 9.61 25 545459 1389 90081574
Ocular hyperaemia 10.45 9.61 272 545212 33526 90049437
Gait deviation 10.44 9.61 6 545478 63 90082900
Pathological fracture 10.43 9.61 27 545457 9633 90073330
Pseudomonas infection 10.42 9.61 136 545348 14729 90068234
Claustrophobia 10.39 9.61 24 545460 1303 90081660
Lower respiratory tract infection bacterial 10.38 9.61 14 545470 493 90082470
Cholangitis 10.36 9.61 17 545467 7165 90075798
Ehlers-Danlos syndrome 10.33 9.61 12 545472 362 90082601
Functional residual capacity abnormal 10.30 9.61 3 545481 3 90082960
Right ventricular systolic pressure 10.30 9.61 3 545481 3 90082960
Cough variant asthma 10.30 9.61 3 545481 3 90082960
Eye injury 10.29 9.61 33 545451 10987 90071976
Pelvic floor dysfunction 10.28 9.61 6 545478 65 90082898
Cholestatic liver injury 10.26 9.61 5 545479 3792 90079171
Abnormal uterine bleeding 10.25 9.61 31 545453 1981 90080982
Oral allergy syndrome 10.23 9.61 7 545477 102 90082861
Dermatitis acneiform 10.18 9.61 14 545470 6340 90076623
Narcolepsy 10.17 9.61 26 545458 1506 90081457
Tongue exfoliation 10.17 9.61 7 545477 103 90082860
Tenosynovitis 10.17 9.61 49 545435 14518 90068445
Inability to afford medication 10.15 9.61 46 545438 3576 90079387
Peptic ulcer 10.14 9.61 62 545422 5413 90077550
Hospice care 10.11 9.61 96 545388 9608 90073355
Menopausal symptoms 10.10 9.61 41 545443 3037 90079926
Migraine 10.07 9.61 1301 544183 189091 89893872
Blood immunoglobulin G abnormal 10.06 9.61 5 545479 38 90082925
Osteomyelitis 10.06 9.61 113 545371 27733 90055230
Breath sounds 10 9.61 7 545477 106 90082857
Skin fragility 9.99 9.61 19 545465 899 90082064
Blood magnesium increased 9.97 9.61 4 545480 3404 90079559
Product lot number issue 9.97 9.61 9 545475 200 90082763
Haemorrhoid operation 9.96 9.61 13 545471 443 90082520
Amylase increased 9.96 9.61 17 545467 7055 90075908
Upper gastrointestinal haemorrhage 9.96 9.61 194 545290 22782 90060181
Atrial tachycardia 9.96 9.61 66 545418 5924 90077039
Nasal ulcer 9.96 9.61 37 545447 2629 90080334
Subdural haematoma 9.95 9.61 59 545425 16586 90066377
Allergy to plants 9.91 9.61 18 545466 822 90082141
Myoclonus 9.90 9.61 71 545413 19097 90063866
Product prescribing issue 9.90 9.61 82 545402 7897 90075066
Depressive symptom 9.89 9.61 60 545424 5225 90077738
Gastrointestinal perforation 9.87 9.61 7 545477 4325 90078638
Escherichia bacteraemia 9.84 9.61 12 545472 5723 90077240
Ovarian fibrosis 9.84 9.61 3 545481 4 90082959
Pancreatitis relapsing 9.82 9.61 24 545460 1352 90081611
Suicidal ideation 9.79 9.61 541 544943 73314 90009649
Urinary casts present 9.78 9.61 7 545477 110 90082853
Cardiogenic shock 9.77 9.61 97 545387 24371 90058592
Nasal cyst 9.75 9.61 5 545479 41 90082922
Reflexes abnormal 9.75 9.61 17 545467 752 90082211
Partial seizures 9.73 9.61 18 545466 7242 90075721
Anencephaly 9.73 9.61 12 545472 386 90082577
Parainfluenzae virus infection 9.73 9.61 38 545446 2765 90080198
Temperature intolerance 9.70 9.61 113 545371 11917 90071046
Epiglottitis 9.68 9.61 14 545470 527 90082436
Cystic lung disease 9.64 9.61 5 545479 42 90082921
Mesenteric haemorrhage 9.64 9.61 5 545479 42 90082921
Wolff-Parkinson-White syndrome 9.64 9.61 9 545475 209 90082754
Gastric cancer 9.63 9.61 10 545474 5126 90077837
Hypoglycaemic coma 9.62 9.61 3 545481 2987 90079976

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 4375.17 11.00 3381 259236 58933 42299785
Wheezing 3129.50 11.00 2636 259981 52145 42306573
Dyspnoea 2130.31 11.00 6755 255862 435866 41922852
Obstructive airways disorder 1433.84 11.00 1202 261415 23557 42335161
Cough 1241.08 11.00 3116 259501 174987 42183731
Full blood count abnormal 1153.83 11.00 1156 261461 28720 42329998
Sleep disorder due to a general medical condition 1067.99 11.00 875 261742 16578 42342140
Chronic obstructive pulmonary disease 1025.18 11.00 1579 261038 61535 42297183
Productive cough 1009.59 11.00 1409 261208 50158 42308560
Therapeutic product effect incomplete 877.06 11.00 1570 261047 69369 42289349
Product quality issue 865.47 11.00 784 261833 17098 42341620
Poor quality device used 652.01 11.00 262 262355 1079 42357639
Infective pulmonary exacerbation of cystic fibrosis 637.78 11.00 465 262152 7353 42351365
Chest discomfort 605.84 11.00 1261 261356 62355 42296363
Loss of personal independence in daily activities 604.51 11.00 1094 261523 48722 42309996
Sputum discoloured 511.47 11.00 455 262162 9677 42349041
Forced expiratory volume decreased 501.52 11.00 399 262218 7231 42351487
Toxicity to various agents 478.47 11.00 425 262192 228711 42130007
Off label use 418.55 11.00 2274 260343 636061 41722657
Completed suicide 383.86 11.00 66 262551 96399 42262319
Nasal congestion 357.88 11.00 648 261969 28853 42329865
Neutropenia 350.64 11.00 428 262189 199003 42159715
Dyspnoea exertional 340.19 11.00 870 261747 49278 42309440
Nasal polyps 323.07 11.00 233 262384 3618 42355100
Lower respiratory tract infection 318.90 11.00 752 261865 40454 42318264
Drug interaction 310.72 11.00 746 261871 266253 42092465
Bronchiectasis 295.22 11.00 453 262164 17566 42341152
Blood immunoglobulin E increased 287.49 11.00 212 262405 3413 42355305
Febrile neutropenia 283.71 11.00 441 262176 185262 42173456
Product dose omission issue 278.61 11.00 1765 260852 152600 42206118
Pulmonary function test decreased 264.93 11.00 245 262372 5487 42353231
Breath sounds abnormal 252.28 11.00 341 262276 11752 42346966
Pneumonia 252.04 11.00 3820 258797 418329 41940389
Thrombocytopenia 251.48 11.00 495 262122 189784 42168934
Eosinophil count increased 248.50 11.00 319 262298 10444 42348274
Device delivery system issue 247.19 11.00 123 262494 914 42357804
Impaired quality of life 245.86 11.00 366 262251 13811 42344907
Cystic fibrosis 238.46 11.00 152 262465 1903 42356815
Dermatitis atopic 230.72 11.00 331 262286 12073 42346645
Drug abuse 229.76 11.00 185 262432 104586 42254132
Respiratory disorder 212.61 11.00 440 262177 21645 42337073
Middle insomnia 207.89 11.00 249 262368 7584 42351134
Disease progression 205.43 11.00 356 262261 143300 42215418
Pancytopenia 200.13 11.00 259 262358 117484 42241234
Sinusitis 199.08 11.00 693 261924 46599 42312119
Bronchitis 196.39 11.00 689 261928 46512 42312206
No adverse event 191.21 11.00 602 262015 38419 42320299
Haemoptysis 188.72 11.00 670 261947 45497 42313221
Asthma-chronic obstructive pulmonary disease overlap syndrome 187.61 11.00 118 262499 1441 42357277
Anaemia 183.27 11.00 997 261620 279281 42079437
Myelosuppression 176.45 11.00 21 262596 40440 42318278
Gastrooesophageal reflux disease 174.35 11.00 642 261975 44381 42314337
Bronchospasm 174.32 11.00 297 262320 12588 42346130
Hepatic function abnormal 166.40 11.00 55 262562 51512 42307206
Secretion discharge 163.38 11.00 218 262399 7417 42351301
Nasopharyngitis 161.08 11.00 976 261641 83020 42275698
Reversible airways obstruction 160.14 11.00 77 262540 526 42358192
Malignant neoplasm progression 158.25 11.00 265 262352 108135 42250583
Diarrhoea 155.22 11.00 1958 260659 458891 41899827
Dust allergy 153.98 11.00 177 262440 5155 42353563
Influenza 153.02 11.00 773 261844 61402 42297316
Emphysema 151.22 11.00 266 262351 11569 42347149
Respiratory symptom 148.93 11.00 255 262362 10851 42347867
Pulmonary function test abnormal 148.05 11.00 127 262490 2567 42356151
Leukopenia 144.73 11.00 148 262469 74598 42284120
Lung disorder 142.90 11.00 630 261987 47293 42311425
Eosinophil count abnormal 142.10 11.00 61 262556 307 42358411
Bronchial wall thickening 141.64 11.00 94 262523 1266 42357452
Eosinophilic granulomatosis with polyangiitis 139.84 11.00 216 262401 8422 42350296
Acute kidney injury 139.66 11.00 1519 261098 365818 41992900
Sleep disorder 135.71 11.00 622 261995 47473 42311245
Platelet count decreased 134.82 11.00 422 262195 138159 42220559
Mucosal inflammation 134.45 11.00 68 262549 49306 42309412
Upper-airway cough syndrome 131.27 11.00 148 262469 4218 42354500
Conjunctivitis allergic 129.91 11.00 171 262446 5740 42352978
Cytomegalovirus infection 128.66 11.00 22 262595 32284 42326434
Drug resistance 128.57 11.00 27 262590 34221 42324497
Rhinorrhoea 127.84 11.00 459 262158 31335 42327383
Chronic sinusitis 126.71 11.00 129 262488 3263 42355455
White blood cell count decreased 123.75 11.00 314 262303 110082 42248636
Bronchial obstruction 123.53 11.00 95 262522 1634 42357084
Cytokine release syndrome 123.24 11.00 60 262557 44467 42314251
Septic shock 122.22 11.00 237 262380 91435 42267283
Intentional overdose 121.58 11.00 84 262533 51372 42307346
Respiratory tract congestion 120.12 11.00 189 262428 7489 42351229
Sputum increased 119.45 11.00 121 262496 3042 42355676
Treatment failure 117.86 11.00 127 262490 62497 42296221
Spirometry abnormal 114.85 11.00 150 262467 4996 42353722
Bronchial secretion retention 114.16 11.00 88 262529 1519 42357199
Renal impairment 114.14 11.00 326 262291 109902 42248816
Upper respiratory tract infection 110.62 11.00 534 262083 41639 42317079
Hypoxia 109.42 11.00 771 261846 69015 42289703
Blood test abnormal 109.13 11.00 244 262373 12662 42346056
Bronchopulmonary aspergillosis allergic 108.85 11.00 138 262479 4460 42354258
Bronchial disorder 106.92 11.00 80 262537 1318 42357400
Pyrexia 106.49 11.00 1748 260869 392294 41966424
Interstitial lung disease 103.58 11.00 204 262413 78258 42280460
Forced vital capacity decreased 102.83 11.00 67 262550 873 42357845
Obstruction 101.61 11.00 110 262507 2993 42355725
Bronchial hyperreactivity 100.07 11.00 88 262529 1841 42356877
Asthmatic crisis 99.73 11.00 54 262563 487 42358231
Coma 99.23 11.00 110 262507 53444 42305274
Mite allergy 98.78 11.00 138 262479 4908 42353810
Mycotic allergy 97.60 11.00 135 262482 4756 42353962
Neutrophil count decreased 97.24 11.00 150 262467 63265 42295453
Illness 96.91 11.00 356 262261 24574 42334144
Lung hyperinflation 96.17 11.00 69 262548 1062 42357656
Bone marrow failure 95.60 11.00 42 262575 33051 42325667
Lung consolidation 94.43 11.00 157 262460 6520 42352198
Seasonal allergy 93.93 11.00 174 262443 7881 42350837
Renal failure 91.68 11.00 515 262102 143211 42215507
Overdose 91.14 11.00 337 262280 104927 42253791
Sinus congestion 89.33 11.00 157 262460 6823 42351895
Allergy to animal 87.97 11.00 50 262567 500 42358218
Tubulointerstitial nephritis 86.56 11.00 43 262574 31505 42327213
Oxygen saturation decreased 85.76 11.00 687 261930 64000 42294718
Hospitalisation 85.63 11.00 765 261852 73565 42285153
Total lung capacity abnormal 84.73 11.00 120 262497 4323 42354395
Congenital hiatus hernia 83.10 11.00 142 262475 6032 42352686
Pneumocystis jirovecii pneumonia 82.74 11.00 26 262591 25155 42333563
Vital capacity decreased 82.69 11.00 47 262570 470 42358248
Nasal obstruction 82.67 11.00 60 262557 941 42357777
Pulmonary vasculitis 81.56 11.00 142 262475 6124 42352594
Sinus pain 79.74 11.00 57 262560 872 42357846
Appendicolith 79.60 11.00 222 262395 13234 42345484
Respiratory rate increased 78.16 11.00 195 262422 10867 42347851
Bronchospasm paradoxical 77.92 11.00 26 262591 53 42358665
Neuritis 77.14 11.00 138 262479 6082 42352636
Rhinitis allergic 76.59 11.00 106 262511 3736 42354982
Neuropathy peripheral 75.71 11.00 346 262271 101507 42257211
Obesity 75.22 11.00 248 262369 16211 42342507
Malaise 74.99 11.00 1773 260844 210383 42148335
Product complaint 72.08 11.00 131 262486 5846 42352872
Drug reaction with eosinophilia and systemic symptoms 71.99 11.00 92 262525 41983 42316735
Stomatitis 69.80 11.00 127 262490 50202 42308516
Rhabdomyolysis 69.35 11.00 247 262370 77772 42280946
Disseminated intravascular coagulation 69.23 11.00 33 262584 24761 42333957
Throat irritation 68.37 11.00 206 262411 12830 42345888
Right atrial hypertrophy 67.38 11.00 47 262570 690 42358028
Discomfort 67.33 11.00 321 262296 24898 42333820
Heart rate increased 67.03 11.00 559 262058 52696 42306022
Stress 66.68 11.00 484 262133 43728 42314990
Chest X-ray abnormal 66.45 11.00 108 262509 4400 42354318
C-reactive protein increased 65.74 11.00 188 262429 63372 42295346
Wrong technique in device usage process 65.66 11.00 83 262534 2674 42356044
Oropharyngeal pain 65.63 11.00 468 262149 42042 42316676
Rhonchi 65.60 11.00 73 262544 2050 42356668
Neoplasm progression 65.04 11.00 50 262567 28950 42329768
Cardiac failure 64.84 11.00 389 262228 106467 42252251
Cerebral infarction 64.64 11.00 58 262559 31111 42327607
Pulmonary mass 62.99 11.00 232 262385 16033 42342685
Multiple allergies 62.85 11.00 95 262522 3633 42355085
Respiration abnormal 62.54 11.00 99 262518 3943 42354775
Blood lactate dehydrogenase increased 62.37 11.00 42 262575 26039 42332679
Lung diffusion test decreased 62.15 11.00 48 262569 831 42357887
Sputum abnormal 62.10 11.00 41 262576 547 42358171
Anxiety 62.01 11.00 1051 261566 117509 42241209
Intentional product use issue 61.48 11.00 231 262386 71602 42287116
Hepatotoxicity 60.90 11.00 40 262577 25127 42333591
Malignant melanoma in situ 60.73 11.00 80 262537 2687 42356031
Drug ineffective for unapproved indication 60.07 11.00 121 262496 46042 42312676
Respiratory tract infection 59.70 11.00 320 262297 26002 42332716
Drug ineffective 59.48 11.00 3228 259389 626969 41731749
Sleep apnoea syndrome 59.11 11.00 277 262340 21331 42337387
Benign prostatic hyperplasia 58.42 11.00 271 262346 20781 42337937
Increased bronchial secretion 58.07 11.00 72 262545 2274 42356444
Fractional exhaled nitric oxide increased 57.94 11.00 60 262557 1549 42357169
Sensitivity to weather change 57.61 11.00 67 262550 1976 42356742
Respiratory distress 57.53 11.00 448 262169 41372 42317346
Cerebral haemorrhage 57.06 11.00 95 262522 38871 42319847
Synovitis 56.95 11.00 13 262604 15554 42343164
Restrictive pulmonary disease 56.76 11.00 55 262562 1308 42357410
Palmar-plantar erythrodysaesthesia syndrome 56.54 11.00 28 262589 20554 42338164
Cytomegalovirus infection reactivation 56.48 11.00 3 262614 11175 42347543
Blood cholesterol 55.83 11.00 28 262589 212 42358506
Therapy partial responder 55.36 11.00 27 262590 19994 42338724
Blood creatinine increased 55.02 11.00 424 262193 109579 42249139
Airway remodelling 54.76 11.00 45 262572 855 42357863
Acute myeloid leukaemia 54.36 11.00 35 262582 22221 42336497
Antineutrophil cytoplasmic antibody positive 54.33 11.00 97 262520 4268 42354450
Rales 54.10 11.00 174 262443 11226 42347492
Joint injury 54.06 11.00 206 262411 14470 42344248
Inhalation therapy 54.05 11.00 16 262601 17 42358701
Total lung capacity decreased 53.26 11.00 86 262531 3484 42355234
Serotonin syndrome 52.52 11.00 49 262568 25796 42332922
Suicide attempt 52.49 11.00 130 262487 45970 42312748
Poisoning 52.35 11.00 13 262604 14686 42344032
Product container issue 52.09 11.00 44 262573 870 42357848
Hyperkalaemia 51.96 11.00 287 262330 80171 42278547
Bronchiolitis 51.47 11.00 89 262528 3817 42354901
Eosinophilic bronchitis 51.26 11.00 27 262590 229 42358489
Increased viscosity of bronchial secretion 51.26 11.00 27 262590 229 42358489
Lung opacity 51.20 11.00 112 262505 5725 42352993
Neuroleptic malignant syndrome 50.78 11.00 35 262582 21437 42337281
Posterior reversible encephalopathy syndrome 50.46 11.00 9 262608 12812 42345906
Transplant rejection 50.41 11.00 11 262606 13577 42345141
Agranulocytosis 50.26 11.00 69 262548 30543 42328175
Cardio-respiratory arrest 49.89 11.00 189 262428 58447 42300271
Haemophagocytic lymphohistiocytosis 49.74 11.00 25 262592 18197 42340521
Altered state of consciousness 49.00 11.00 65 262552 29194 42329524
Colitis 48.71 11.00 137 262480 46435 42312283
Viral infection 48.08 11.00 269 262348 22214 42336504
Haematochezia 48.02 11.00 191 262426 58245 42300473
Neurotoxicity 47.87 11.00 45 262572 23606 42335112
Throat tightness 47.83 11.00 149 262468 9450 42349268
Tumour lysis syndrome 47.76 11.00 40 262577 22191 42336527
Confusional state 47.58 11.00 736 261881 166861 42191857
Encephalopathy 47.49 11.00 116 262501 41217 42317501
Peak expiratory flow rate decreased 47.49 11.00 21 262596 115 42358603
Depressed level of consciousness 47.35 11.00 145 262472 47825 42310893
Thrombotic microangiopathy 47.27 11.00 16 262601 14766 42343952
Atelectasis 46.39 11.00 239 262378 19122 42339596
Appendicitis 46.34 11.00 250 262367 20363 42338355
Nodule 46.22 11.00 176 262441 12358 42346360
Dysphonia 46.13 11.00 317 262300 28133 42330585
Lower respiratory tract congestion 46.01 11.00 53 262564 1547 42357171
Atopy 45.69 11.00 42 262575 933 42357785
Progressive multifocal leukoencephalopathy 45.61 11.00 8 262609 11528 42347190
Hypoventilation 45.43 11.00 83 262534 3719 42354999
Chest pain 45.30 11.00 1153 261464 138377 42220341
Immune reconstitution inflammatory syndrome 44.88 11.00 5 262612 10138 42348580
Vasculitis 44.73 11.00 228 262389 18166 42340552
Increased upper airway secretion 44.32 11.00 66 262551 2490 42356228
Akathisia 44.16 11.00 6 262611 10445 42348273
Hepatic cytolysis 43.58 11.00 61 262556 26783 42331935
Circumstance or information capable of leading to medication error 43.44 11.00 65 262552 2463 42356255
Polyneuropathy 43.36 11.00 31 262586 18630 42340088
FEV1/FVC ratio decreased 43.20 11.00 20 262597 124 42358594
Drug eruption 43.17 11.00 47 262570 23028 42335690
Therapy non-responder 42.84 11.00 176 262441 53183 42305535
Rheumatoid arthritis 42.81 11.00 127 262490 42313 42316405
Proteinuria 42.79 11.00 47 262570 22936 42335782
Dyspnoea at rest 42.47 11.00 86 262531 4163 42354555
Hypersensitivity 42.08 11.00 653 261964 71717 42287001
Death 42.01 11.00 2426 260191 468759 41889959
Sneezing 41.67 11.00 109 262508 6254 42352464
Metabolic acidosis 41.67 11.00 171 262446 51687 42307031
Hypotension 41.37 11.00 1240 261377 256391 42102327
Graft versus host disease 41.31 11.00 14 262603 12911 42345807
Decreased activity 41.10 11.00 95 262522 5040 42353678
Eye pruritus 41.06 11.00 159 262458 11253 42347465
Pulmonary fibrosis 40.75 11.00 293 262324 26388 42332330
Peritonitis 40.68 11.00 33 262584 18600 42340118
Right ventricular hypertrophy 40.63 11.00 49 262568 1503 42357215
Body temperature decreased 40.33 11.00 186 262431 14227 42344491
Psoriatic arthropathy 40.26 11.00 57 262560 24910 42333808
Product dose omission in error 40.09 11.00 128 262489 8226 42350492
Osteonecrosis of jaw 40.04 11.00 35 262582 19014 42339704
Throat clearing 39.97 11.00 32 262585 585 42358133
Extrapyramidal disorder 39.82 11.00 26 262591 16386 42342332
Alanine aminotransferase increased 39.53 11.00 351 262266 88055 42270663
Cytopenia 39.45 11.00 30 262587 17467 42341251
Sopor 39.34 11.00 16 262601 13186 42345532
Cytomegalovirus viraemia 39.32 11.00 8 262609 10369 42348349
Spinal muscular atrophy 39.14 11.00 27 262590 389 42358329
Haemoglobin decreased 38.86 11.00 578 262039 131893 42226825
Painful respiration 38.78 11.00 45 262572 1324 42357394
Forced expiratory flow decreased 38.75 11.00 20 262597 162 42358556
Sedation 38.69 11.00 81 262536 30394 42328324
Cystic fibrosis respiratory infection suppression 38.68 11.00 23 262594 252 42358466
Foetal exposure during pregnancy 38.64 11.00 155 262462 47156 42311562
Smoke sensitivity 38.63 11.00 21 262596 191 42358527
Respiratory failure 38.18 11.00 1047 261570 127085 42231633
Rash maculo-papular 37.99 11.00 112 262505 37391 42321327
Pancreatitis acute 37.93 11.00 95 262522 33469 42325249
Plantar fasciitis 37.93 11.00 68 262549 3002 42355716
Injection site pain 37.71 11.00 532 262085 57266 42301452
Normochromic normocytic anaemia 37.68 11.00 132 262485 8899 42349819
Blood phosphorus increased 37.57 11.00 165 262452 12360 42346358
Upper respiratory fungal infection 37.54 11.00 20 262597 174 42358544
Device malfunction 37.44 11.00 163 262454 12164 42346554
Neurological symptom 37.42 11.00 141 262476 9850 42348868
Device ineffective 37.14 11.00 12 262605 21 42358697
Hyperammonaemia 37.12 11.00 3 262614 7863 42350855
Product delivery mechanism issue 36.77 11.00 22 262595 244 42358474
Crepitations 36.60 11.00 71 262546 3330 42355388
Wall motion score index abnormal 36.55 11.00 35 262582 820 42357898
Acute respiratory failure 35.92 11.00 382 262235 38476 42320242
Pathogen resistance 35.57 11.00 13 262604 11437 42347281
Metastases to liver 35.53 11.00 29 262588 16297 42342421
Hyperbilirubinaemia 35.42 11.00 45 262572 20590 42338128
C-reactive protein abnormal 35.38 11.00 7 262610 9254 42349464
Chronic kidney disease 35.37 11.00 160 262457 47081 42311637
Vocal cord dysfunction 35.36 11.00 20 262597 198 42358520
Anaphylactic reaction 35.32 11.00 411 262206 42332 42316386
Drug use disorder 35.16 11.00 10 262607 10323 42348395
Eosinophilia 35.03 11.00 333 262284 32566 42326152
BK virus infection 34.93 11.00 6 262611 8778 42349940
Epidural lipomatosis 34.89 11.00 49 262568 1751 42356967
Central nervous system mass 34.80 11.00 34 262583 817 42357901
Drug-induced liver injury 34.78 11.00 120 262497 38153 42320565
Snoring 34.58 11.00 76 262541 3897 42354821
Immune effector cell-associated neurotoxicity syndrome 34.41 11.00 8 262609 9453 42349265
Eye swelling 34.22 11.00 155 262462 11765 42346953
Eosinophil count 34.12 11.00 19 262598 182 42358536
Lung diffusion disorder 33.85 11.00 18 262599 156 42358562
Lacrimation increased 33.84 11.00 153 262464 11605 42347113
Micturition urgency 33.63 11.00 154 262463 11744 42346974
Victim of child abuse 33.54 11.00 39 262578 1150 42357568
Hyperthermia 33.21 11.00 18 262599 12556 42346162
Forced expiratory volume 33.19 11.00 16 262601 110 42358608
Blood immunoglobulin E decreased 33.03 11.00 13 262604 50 42358668
Hepatic failure 32.93 11.00 122 262495 37978 42320740
Parathyroid gland enlargement 32.81 11.00 18 262599 167 42358551
Lymph node calcification 32.80 11.00 17 262600 139 42358579
Myelodysplastic syndrome 32.79 11.00 56 262561 22689 42336029
Respiratory tract irritation 32.73 11.00 22 262595 303 42358415
Exposure via skin contact 32.68 11.00 86 262531 4952 42353766
Status asthmaticus 32.67 11.00 22 262595 304 42358414
Sensation of foreign body 32.46 11.00 70 262547 3543 42355175
Toxic epidermal necrolysis 32.39 11.00 73 262544 26677 42332041
Nasal disorder 32.18 11.00 50 262567 1959 42356759
Ear infection 32.04 11.00 160 262457 12644 42346074
Acute graft versus host disease in skin 32 11.00 4 262613 7420 42351298
Respiratory syncytial virus infection 32.00 11.00 107 262510 7045 42351673
Hepatitis 31.85 11.00 76 262541 27224 42331494
Perfume sensitivity 31.80 11.00 17 262600 149 42358569
Intercepted product preparation error 31.80 11.00 4 262613 7385 42351333
Product prescribing error 31.73 11.00 272 262345 25840 42332878
Deep vein thrombosis 31.63 11.00 312 262305 76645 42282073
Syringe issue 31.59 11.00 7 262610 8549 42350169
Pancreatitis 31.52 11.00 148 262469 43120 42315598
Infusion related reaction 31.51 11.00 232 262385 60574 42298144
Cystitis haemorrhagic 31.47 11.00 4 262613 7325 42351393
Sinus disorder 31.32 11.00 115 262502 7935 42350783
Nasal inflammation 30.90 11.00 24 262593 419 42358299
Nephropathy toxic 30.73 11.00 35 262582 16803 42341915
Choking 30.68 11.00 97 262520 6201 42352517
Soft tissue mass 29.90 11.00 34 262583 978 42357740
Acute generalised exanthematous pustulosis 29.84 11.00 8 262609 8587 42350131
Bronchopulmonary aspergillosis 29.73 11.00 46 262571 19383 42339335
Brain oedema 29.73 11.00 34 262583 16293 42342425
Iron deficiency 29.67 11.00 141 262476 10920 42347798
Coagulation factor V level abnormal 29.67 11.00 16 262601 143 42358575
Cardiac septal defect 29.64 11.00 33 262584 927 42357791
Sepsis 29.64 11.00 969 261648 198365 42160353
Analgesic therapy 29.54 11.00 98 262519 6426 42352292
Herpes zoster 29.50 11.00 131 262486 38746 42319972
Renal tubular necrosis 29.50 11.00 42 262575 18312 42340406
Seizure 29.45 11.00 544 262073 120017 42238701
Foetal malformation 29.41 11.00 17 262600 176 42358542
Incorrect dose administered 29.28 11.00 474 262143 52500 42306218
Febrile bone marrow aplasia 29.28 11.00 13 262604 10168 42348550
Cholestasis 29.26 11.00 104 262513 32775 42325943
Disorientation 29.22 11.00 120 262497 36269 42322449
Product taste abnormal 29.03 11.00 37 262580 1202 42357516
Suffocation feeling 29.03 11.00 28 262589 662 42358056
Nasal discharge discolouration 28.75 11.00 23 262594 420 42358298
Factor V Leiden mutation 28.60 11.00 18 262599 220 42358498
Epstein-Barr virus infection 28.59 11.00 12 262605 9706 42349012
Coagulation factor deficiency 28.49 11.00 19 262598 258 42358460
Drug therapy 28.14 11.00 95 262522 6285 42352433
Gamma-glutamyltransferase increased 28.12 11.00 104 262513 32393 42326325
Aspartate aminotransferase increased 28.01 11.00 322 262295 76841 42281877
Second primary malignancy 27.89 11.00 12 262605 9563 42349155
Myocarditis 27.88 11.00 46 262571 18892 42339826
Escherichia infection 27.72 11.00 18 262599 11378 42347340
Hypercholesterolaemia 27.65 11.00 154 262463 12695 42346023
Psychotic disorder 27.62 11.00 90 262527 29118 42329600
Pickwickian syndrome 27.59 11.00 14 262603 109 42358609
Suspected suicide 27.57 11.00 3 262614 6196 42352522
Brain scan abnormal 27.47 11.00 36 262581 1203 42357515
Klebsiella infection 27.43 11.00 18 262599 11314 42347404
Dry skin 27.27 11.00 434 262183 47904 42310814
Cerebral artery thrombosis 27.24 11.00 36 262581 1213 42357505
Factitious disorder 27.24 11.00 11 262606 46 42358672
Food allergy 27.19 11.00 49 262568 2172 42356546
Frequent bowel movements 27.09 11.00 57 262560 21350 42337368
Multiple-drug resistance 27.01 11.00 6 262611 7316 42351402
Sinus polyp 26.83 11.00 18 262599 247 42358471
Kidney transplant rejection 26.73 11.00 10 262607 8673 42350045
Sleep terror 26.64 11.00 57 262560 2869 42355849
Hormone receptor positive breast cancer 26.57 11.00 10 262607 33 42358685
Hypercapnia 26.51 11.00 83 262534 5278 42353440
Bradycardia 26.45 11.00 369 262248 85115 42273603
Catarrh 26.36 11.00 3 262614 5983 42352735
Urinary tract infection 26.15 11.00 442 262175 98842 42259876
Mucormycosis 26.06 11.00 6 262611 7137 42351581
Eosinophilic myocarditis 26.06 11.00 37 262580 1336 42357382
Rhinitis perennial 26.03 11.00 16 262601 187 42358531
Anger 26.02 11.00 153 262464 12865 42345853
Squamous cell carcinoma of skin 26.00 11.00 24 262593 12702 42346016
Lymphocyte count 25.99 11.00 17 262600 223 42358495
Hyperthyroidism 25.96 11.00 30 262587 14311 42344407
Pulmonary congestion 25.93 11.00 176 262441 15554 42343164
Lower respiratory tract infection bacterial 25.85 11.00 24 262593 540 42358178
Brain natriuretic peptide increased 25.74 11.00 96 262521 6674 42352044
Skin discomfort 25.70 11.00 27 262590 709 42358009
Therapeutic response shortened 25.63 11.00 157 262460 13397 42345321
Hypercalcaemia 25.54 11.00 45 262572 18013 42340705
Venoocclusive liver disease 25.43 11.00 16 262601 10286 42348432
Shock 25.33 11.00 93 262524 29028 42329690
Cardiac arrest 25.24 11.00 498 262119 108822 42249896
Superinfection 25.18 11.00 56 262561 2895 42355823
Systemic lupus erythematosus 25.14 11.00 13 262604 9311 42349407
Pulmonary toxicity 24.97 11.00 11 262606 8644 42350074
Ataxia 24.84 11.00 38 262579 16087 42342631
Lymphoma 24.82 11.00 31 262586 14290 42344428
Liver disorder 24.72 11.00 143 262474 39501 42319217
Poisoning deliberate 24.66 11.00 16 262601 10118 42348600
Delirium 24.59 11.00 206 262411 52313 42306405
Lip swelling 24.50 11.00 201 262416 18852 42339866
Hypoacusis 24.42 11.00 198 262419 18504 42340214
Rectal haemorrhage 24.41 11.00 192 262425 49414 42309304
Mycobacterial infection 24.32 11.00 52 262565 2616 42356102
Diffuse large B-cell lymphoma 24.30 11.00 14 262603 9440 42349278
Accidental overdose 24.30 11.00 91 262526 28239 42330479
Mycobacterium avium complex infection 24.22 11.00 56 262561 2971 42355747
Nervous system disorder 24.18 11.00 43 262574 17152 42341566
Osteoporosis 24.11 11.00 166 262451 14740 42343978
Metastases to lung 24.00 11.00 21 262596 11403 42347315
Injection site swelling 23.99 11.00 183 262434 16790 42341928
Abnormal behaviour 23.97 11.00 259 262358 26192 42332526
Sinus operation 23.91 11.00 28 262589 832 42357886
Low birth weight baby 23.84 11.00 16 262601 9939 42348779
Urticaria 23.77 11.00 611 262006 73425 42285293
Jaundice 23.64 11.00 121 262496 34468 42324250
Pneumonia lipoid 23.58 11.00 12 262605 94 42358624
Pulmonary eosinophilia 23.51 11.00 17 262600 265 42358453
Aplastic anaemia 23.41 11.00 25 262592 12359 42346359
Urinary retention 23.36 11.00 158 262459 42056 42316662
Capillaritis 23.35 11.00 46 262571 2182 42356536
Hypertriglyceridaemia 23.29 11.00 17 262600 10109 42348609
Dehydration 23.29 11.00 680 261937 141087 42217631
Hepatitis cholestatic 23.25 11.00 16 262601 9808 42348910
Drug level increased 23.23 11.00 83 262534 26117 42332601
Enterococcal infection 23.10 11.00 24 262593 12015 42346703
Myoglobin blood increased 23.02 11.00 62 262555 3620 42355098
Forced expiratory volume abnormal 22.99 11.00 9 262608 34 42358684
Neuropsychiatric symptoms 22.92 11.00 26 262591 746 42357972
Swelling face 22.78 11.00 265 262352 27289 42331429
Dyslipidaemia 22.74 11.00 15 262602 9403 42349315
Gastrointestinal haemorrhage 22.62 11.00 445 262172 97281 42261437
Squamous cell carcinoma 22.60 11.00 28 262589 12954 42345764
Wolff-Parkinson-White syndrome 22.54 11.00 16 262601 242 42358476
Restlessness 22.53 11.00 98 262519 29151 42329567
Drug intolerance 22.51 11.00 354 262263 80070 42278648
Miosis 22.38 11.00 30 262587 13416 42345302
Fall 22.36 11.00 1199 261418 233321 42125397
Sleep disorder therapy 22.36 11.00 93 262524 6801 42351917
Hepatocellular injury 22.36 11.00 73 262544 23605 42335113
Carbon dioxide increased 22.28 11.00 33 262584 1239 42357479
Eye disorder 22.27 11.00 135 262482 11477 42347241
Stoma closure 22.17 11.00 17 262600 291 42358427
Anuria 22.12 11.00 23 262594 11509 42347209
Expiratory reserve volume decreased 22.09 11.00 12 262605 109 42358609
Dysmetropsia 22.07 11.00 8 262609 23 42358695
Pneumothorax 22.02 11.00 232 262385 23311 42335407
Blood creatine phosphokinase increased 22.00 11.00 191 262426 48147 42310571
Aortic valve stenosis 22.00 11.00 54 262563 2978 42355740
Multimorbidity 21.99 11.00 28 262589 909 42357809
Hypoalbuminaemia 21.98 11.00 39 262578 15571 42343147
Nausea 21.97 11.00 2126 260491 394673 41964045
Gout 21.96 11.00 267 262350 27788 42330930
Hepatitis B 21.92 11.00 7 262610 6704 42352014
Haematuria 21.84 11.00 239 262378 57560 42301158
Acute myocardial infarction 21.78 11.00 241 262376 57924 42300794
Blood urea increased 21.70 11.00 116 262501 32677 42326041
Graft versus host disease in gastrointestinal tract 21.62 11.00 3 262614 5140 42353578
Decreased appetite 21.62 11.00 971 261646 192166 42166552
Multiple sclerosis relapse 21.61 11.00 34 262583 14230 42344488
Encephalitis 21.56 11.00 15 262602 9143 42349575
Blood pressure increased 21.46 11.00 799 261818 101129 42257589
Hyperuricaemia 21.45 11.00 16 262601 9408 42349310
Somnolence 21.42 11.00 684 261933 140421 42218297
Exposure to fungus 21.40 11.00 7 262610 13 42358705
Mechanical ventilation complication 21.40 11.00 24 262593 680 42358038
Cystic fibrosis related diabetes 21.38 11.00 14 262603 184 42358534
Alcohol poisoning 21.27 11.00 10 262607 7564 42351154
Skin toxicity 21.09 11.00 7 262610 6542 42352176
Blood bilirubin increased 21.04 11.00 163 262454 42089 42316629
Dermatitis exfoliative generalised 21.03 11.00 5 262612 5819 42352899
FEV1/FVC ratio abnormal 21.01 11.00 9 262608 45 42358673
Right atrial enlargement 20.96 11.00 16 262601 272 42358446
Paranasal sinus discomfort 20.89 11.00 31 262586 1166 42357552
Arteriosclerosis coronary artery 20.86 11.00 191 262426 18486 42340232
Metastases to bone 20.86 11.00 37 262580 14772 42343946
Immune thrombocytopenia 20.81 11.00 23 262594 11193 42347525
Subdural haematoma 20.71 11.00 73 262544 23065 42335653
Disease complication 20.52 11.00 53 262564 3017 42355701
Blood alkaline phosphatase increased 20.52 11.00 122 262495 33475 42325243
Substance use disorder 20.50 11.00 4 262613 5341 42353377
Hepatic enzyme increased 20.36 11.00 182 262435 45602 42313116
Inspiratory capacity abnormal 20.33 11.00 11 262606 99 42358619
Abnormal clotting factor 20.24 11.00 10 262607 73 42358645
Drug level decreased 20.17 11.00 19 262598 9958 42348760
Basal cell carcinoma 20.17 11.00 72 262545 22661 42336057
Infective exacerbation of chronic obstructive airways disease 20.14 11.00 41 262576 1992 42356726
Nasal oedema 20.13 11.00 17 262600 336 42358382
Myasthenia gravis 20.08 11.00 169 262448 15968 42342750
Enthesopathy 19.87 11.00 3 262614 4825 42353893
Chronic respiratory failure 19.83 11.00 37 262580 1685 42357033
Graft versus host disease in skin 19.78 11.00 4 262613 5208 42353510
Vascular shunt 19.71 11.00 8 262609 34 42358684
Oliguria 19.71 11.00 17 262600 9296 42349422
Oesophageal polyp 19.68 11.00 9 262608 54 42358664
Tracheal disorder 19.65 11.00 15 262602 255 42358463
Subarachnoid haemorrhage 19.63 11.00 37 262580 14435 42344283
Toxic skin eruption 19.61 11.00 34 262583 13696 42345022
Encephalitis toxic 19.31 11.00 15 262602 262 42358456
Status epilepticus 19.28 11.00 42 262575 15536 42343182
Blood pressure systolic increased 19.28 11.00 260 262357 27708 42331010
Bacteraemia 19.23 11.00 84 262533 24956 42333762
Multiple organ dysfunction syndrome 19.22 11.00 453 262164 96582 42262136
Microangiopathy 19.19 11.00 36 262581 1646 42357072
Asthenia 19.14 11.00 1480 261137 279313 42079405
Allergy to chemicals 18.94 11.00 11 262606 115 42358603
Hyperglycaemia 18.81 11.00 186 262431 45673 42313045
Dysarthria 18.70 11.00 156 262461 39651 42319067
Ocular discomfort 18.64 11.00 51 262566 3006 42355712
Asthma exercise induced 18.62 11.00 11 262606 119 42358599
Small airways disease 18.52 11.00 8 262609 41 42358677
Dry mouth 18.50 11.00 347 262270 39532 42319186
Viral upper respiratory tract infection 18.46 11.00 52 262565 3117 42355601
Eczema 18.46 11.00 304 262313 33782 42324936
Social avoidant behaviour 18.44 11.00 54 262563 3310 42355408
Flour sensitivity 18.40 11.00 7 262610 24 42358694
Attention-seeking behaviour 18.36 11.00 8 262609 42 42358676
Dementia 18.34 11.00 47 262570 16433 42342285
Cor pulmonale acute 18.30 11.00 15 262602 284 42358434
Toxic encephalopathy 18.30 11.00 10 262607 6943 42351775
Colitis ulcerative 18.21 11.00 91 262526 26084 42332634
Hypertransaminasaemia 18.15 11.00 18 262599 9209 42349509
Gastroenteritis viral 18.13 11.00 99 262518 8100 42350618
Extra dose administered 18.01 11.00 76 262541 5593 42353125
Myoclonus 17.99 11.00 50 262567 17015 42341703
Mean platelet volume increased 17.96 11.00 21 262596 623 42358095
Hepatic fibrosis 17.96 11.00 4 262613 4868 42353850
Bronchial irritation 17.92 11.00 8 262609 45 42358673
Tic 17.89 11.00 43 262574 2340 42356378
Aplasia pure red cell 17.87 11.00 11 262606 7155 42351563
Accessory spleen 17.87 11.00 11 262606 129 42358589
Use of accessory respiratory muscles 17.84 11.00 19 262598 507 42358211
Mood swings 17.82 11.00 104 262513 8722 42349996
Tracheomalacia 17.76 11.00 16 262601 346 42358372
Pneumococcal sepsis 17.68 11.00 32 262585 1423 42357295
Ejection fraction decreased 17.63 11.00 73 262544 22014 42336704
Croup infectious 17.58 11.00 19 262598 516 42358202
Influenza B virus test positive 17.51 11.00 10 262607 101 42358617
Oesophageal perforation 17.44 11.00 29 262588 1204 42357514
Haemolysis 17.42 11.00 20 262597 9569 42349149
Cognitive disorder 17.40 11.00 131 262486 34041 42324677
Animal scratch 17.38 11.00 13 262604 214 42358504
Visual acuity reduced 17.35 11.00 53 262564 17497 42341221
Pulmonary alveolar haemorrhage 17.31 11.00 153 262464 14663 42344055
Hydronephrosis 17.30 11.00 29 262588 11836 42346882
Panic reaction 17.27 11.00 35 262582 1695 42357023
Rhinovirus infection 17.22 11.00 83 262534 6465 42352253
Bladder cancer 17.20 11.00 51 262566 16996 42341722
Hypocalcaemia 17.17 11.00 112 262505 30061 42328657
Prescribed underdose 17.05 11.00 23 262594 10259 42348459
Tenosynovitis 17.02 11.00 4 262613 4691 42354027
Motor neurone disease 16.89 11.00 19 262598 540 42358178
Brain abscess 16.87 11.00 3 262614 4281 42354437
Accelerated idioventricular rhythm 16.82 11.00 12 262605 183 42358535
Wrong technique in product usage process 16.79 11.00 362 262255 42273 42316445
Ocular hyperaemia 16.71 11.00 161 262456 15802 42342916
Prostate cancer 16.70 11.00 185 262432 44458 42314260
Pleuritic pain 16.70 11.00 87 262530 6990 42351728
Aphasia 16.60 11.00 84 262533 23999 42334719
Breath alcohol test positive 16.57 11.00 5 262612 6 42358712
Lymphocyte count decreased 16.45 11.00 102 262515 27707 42331011
Antacid therapy 16.38 11.00 65 262552 4652 42354066
Polyp 16.37 11.00 64 262553 4550 42354168
Sensory integrative dysfunction 16.34 11.00 7 262610 35 42358683
Bradyphrenia 16.30 11.00 6 262611 5256 42353462
Sputum purulent 16.27 11.00 21 262596 691 42358027
Anal fistula 16.25 11.00 9 262608 6204 42352514
Anticoagulant therapy 16.16 11.00 63 262554 4472 42354246
Rubber sensitivity 16.13 11.00 16 262601 392 42358326
Stevens-Johnson syndrome 16.07 11.00 76 262541 22102 42336616
Juvenile idiopathic arthritis 16.06 11.00 44 262573 2595 42356123
Product administered to patient of inappropriate age 16.05 11.00 65 262552 4696 42354022
Bronchomalacia 16.03 11.00 11 262606 157 42358561
Cockroach allergy 16.03 11.00 7 262610 37 42358681
Pharyngeal oedema 16.02 11.00 77 262540 5991 42352727
Melaena 15.95 11.00 157 262460 38589 42320129
Humidity intolerance 15.90 11.00 6 262611 20 42358698
Cholangitis 15.84 11.00 26 262591 10701 42348017
Mycobacterium test positive 15.81 11.00 17 262600 459 42358259
Rhinitis 15.75 11.00 127 262490 11850 42346868
Aspirin-exacerbated respiratory disease 15.68 11.00 14 262603 299 42358419
Adjustment disorder 15.66 11.00 29 262588 1313 42357405
Endophthalmitis 15.63 11.00 4 262613 4429 42354289
Dyskinesia 15.61 11.00 92 262525 25298 42333420
Device related infection 15.59 11.00 68 262549 20211 42338507
Hypokalaemia 15.57 11.00 330 262287 71391 42287327
Prostatic specific antigen increased 15.42 11.00 53 262564 16872 42341846
Haemodynamic instability 15.42 11.00 34 262583 12523 42346195
Infusion site swelling 15.40 11.00 50 262567 3242 42355476
Product cleaning inadequate 15.39 11.00 5 262612 9 42358709
Crying 15.36 11.00 79 262538 6315 42352403
Gait disturbance 15.36 11.00 473 262144 97527 42261191
Exercise tolerance decreased 15.32 11.00 76 262541 5990 42352728
Haemophilus infection 15.32 11.00 31 262586 1500 42357218
Clostridium difficile colitis 15.30 11.00 73 262544 21179 42337539
Pleural thickening 15.20 11.00 17 262600 480 42358238
Cystic fibrosis lung 15.17 11.00 8 262609 68 42358650
Skin exfoliation 15.16 11.00 349 262268 41204 42317514
Congestive cardiomyopathy 15.16 11.00 19 262598 8745 42349973
Infective exacerbation of bronchiectasis 15.15 11.00 17 262600 482 42358236
Therapeutic product effect decreased 15.14 11.00 161 262456 38989 42319729
Device leakage 15.12 11.00 25 262592 10260 42348458
Scoliosis 15.09 11.00 48 262569 3078 42355640
Acute graft versus host disease in intestine 15.06 11.00 3 262614 3948 42354770
Morning sickness 15.05 11.00 5 262612 10 42358708
Chronic respiratory disease 15.05 11.00 10 262607 135 42358583
Pancreatic carcinoma 15.03 11.00 22 262595 9484 42349234
Cardiac tamponade 15.02 11.00 11 262606 6529 42352189
Exposure to toxic agent 15.01 11.00 6 262611 4998 42353720
Lymphopenia 14.98 11.00 75 262542 21488 42337230
Upper respiratory tract congestion 14.94 11.00 24 262593 968 42357750
Adenovirus infection 14.94 11.00 12 262605 6797 42351921
Fistula 14.93 11.00 16 262601 7896 42350822
Eye irritation 14.87 11.00 120 262497 11198 42347520
Decreased gait velocity 14.76 11.00 11 262606 180 42358538
Haemolytic anaemia 14.76 11.00 33 262584 12094 42346624
Central nervous system lesion 14.75 11.00 16 262601 7854 42350864
Diaphragmatic disorder 14.74 11.00 27 262590 1212 42357506
Ventricular hyperkinesia 14.69 11.00 12 262605 226 42358492
Substance abuse 14.69 11.00 20 262597 8885 42349833
Anal abscess 14.67 11.00 16 262601 7834 42350884
Dry eye 14.59 11.00 153 262464 15353 42343365
Product administration interrupted 14.57 11.00 65 262552 4901 42353817
Diastolic dysfunction 14.56 11.00 83 262534 6900 42351818
Stridor 14.37 11.00 44 262573 2764 42355954
Pulmonary tuberculosis 14.35 11.00 8 262609 5493 42353225
Muscular weakness 14.34 11.00 398 262219 83100 42275618
Withdrawal syndrome 14.33 11.00 45 262572 14730 42343988
Diabetic ketoacidosis 14.31 11.00 80 262537 22287 42336431
Mucosal hypertrophy 14.30 11.00 7 262610 50 42358668
Inappropriate antidiuretic hormone secretion 14.27 11.00 53 262564 16488 42342230
Cerebrovascular accident 14.25 11.00 473 262144 96687 42262031
Nasal turbinate abnormality 14.18 11.00 7 262610 51 42358667
Gastric ulcer 14.18 11.00 61 262556 18201 42340517
Percussion test abnormal 14.17 11.00 6 262611 29 42358689
Nasal septum deviation 14.15 11.00 27 262590 1251 42357467
Hepatic steatosis 14.11 11.00 76 262541 21372 42337346
Drug withdrawal syndrome neonatal 13.97 11.00 5 262612 4456 42354262
Stiff person syndrome 13.93 11.00 11 262606 197 42358521
Infusion site pain 13.91 11.00 68 262549 5327 42353391
Alveolar bone resorption 13.89 11.00 5 262612 14 42358704
Cardiogenic shock 13.84 11.00 302 262315 35338 42323380
Exostosis 13.83 11.00 70 262547 5561 42353157
Cholestatic liver injury 13.76 11.00 3 262614 3706 42355012
Myocardial infarction 13.75 11.00 624 261993 123385 42235333
Diverticulitis 13.74 11.00 83 262534 22690 42336028
Insurance issue 13.72 11.00 56 262561 4060 42354658
Renal injury 13.68 11.00 35 262582 12245 42346473
Bone erosion 13.68 11.00 5 262612 4398 42354320
Acute lymphocytic leukaemia recurrent 13.67 11.00 3 262614 3688 42355030
Foreign body in throat 13.66 11.00 17 262600 539 42358179
Physical product label issue 13.63 11.00 4 262613 4 42358714
Bradypnoea 13.62 11.00 5 262612 4388 42354330
Prolonged expiration 13.59 11.00 13 262604 304 42358414
Tachypnoea 13.57 11.00 198 262419 21464 42337254
Inguinal hernia repair 13.53 11.00 13 262604 306 42358412
Nasal discomfort 13.47 11.00 30 262587 1552 42357166
Pulmonary artery dilatation 13.42 11.00 13 262604 309 42358409
Blood immunoglobulin E abnormal 13.40 11.00 5 262612 16 42358702
Lymphadenectomy 13.39 11.00 16 262601 486 42358232
Steroid dependence 13.36 11.00 13 262604 6709 42352009
Scratch 13.34 11.00 66 262551 5195 42353523
Hepatic encephalopathy 13.34 11.00 54 262563 16388 42342330
Cytomegalovirus colitis 13.28 11.00 4 262613 3977 42354741
Ventricular fibrillation 13.25 11.00 260 262357 29863 42328855
Mouth swelling 13.23 11.00 37 262580 2209 42356509
Mydriasis 13.19 11.00 21 262596 8749 42349969
Bed bug infestation 13.17 11.00 4 262613 5 42358713
Dermatitis acneiform 13.15 11.00 17 262600 7722 42350996
Bronchitis viral 13.15 11.00 12 262605 264 42358454
Oxygen saturation abnormal 13.15 11.00 34 262583 1937 42356781
Lung diffusion test abnormal 13.13 11.00 7 262610 61 42358657
Hypochromasia 13.12 11.00 13 262604 318 42358400
Gingival pain 13.10 11.00 20 262597 8474 42350244
Liver injury 13.08 11.00 67 262550 19081 42339637
Hypertensive crisis 13.06 11.00 27 262590 10179 42348539
Necrosis 13.06 11.00 13 262604 6638 42352080
Diastolic hypertension 13.03 11.00 7 262610 62 42358656
Peritonitis bacterial 13.03 11.00 14 262603 6901 42351817
Lacrimal disorder 13.02 11.00 13 262604 321 42358397
Oxygen therapy 13.00 11.00 27 262590 1331 42357387
Nephrotic syndrome 13.00 11.00 21 262596 8697 42350021
Gastric cancer 12.98 11.00 14 262603 6889 42351829
Pharyngitis streptococcal 12.95 11.00 53 262564 3847 42354871
Tracheostomy malfunction 12.94 11.00 7 262610 63 42358655
Fungal infection 12.91 11.00 70 262547 19652 42339066
Hemiparesis 12.91 11.00 59 262558 17317 42341401
Nocardiosis 12.90 11.00 8 262609 5182 42353536
Panic attack 12.87 11.00 114 262503 10931 42347787
Hepatic cirrhosis 12.86 11.00 70 262547 19632 42339086
Blood pressure fluctuation 12.84 11.00 105 262512 26803 42331915
Angina pectoris 12.84 11.00 135 262482 32761 42325957
Coronary artery stenosis 12.83 11.00 28 262589 10351 42348367
Subileus 12.76 11.00 3 262614 3518 42355200
Hypokalaemic syndrome 12.75 11.00 4 262613 6 42358712
Arteriosclerosis 12.71 11.00 168 262449 17821 42340897
Eye discharge 12.69 11.00 44 262573 2951 42355767
Premature baby 12.64 11.00 87 262530 23066 42335652
Cardiac failure chronic 12.63 11.00 25 262592 9576 42349142
Fracture 12.57 11.00 19 262598 8084 42350634
Asbestosis 12.55 11.00 11 262606 229 42358489
Aptyalism 12.50 11.00 14 262603 396 42358322
Fungal disease carrier 12.50 11.00 14 262603 396 42358322
Arteritis coronary 12.49 11.00 7 262610 68 42358650
Immune-mediated enterocolitis 12.46 11.00 10 262607 5667 42353051
Leukocytosis 12.39 11.00 120 262497 29588 42329130
Functional residual capacity increased 12.38 11.00 4 262613 7 42358711
Total lung capacity increased 12.38 11.00 4 262613 7 42358711
Osteomyelitis 12.31 11.00 64 262553 18159 42340559
Increased viscosity of upper respiratory secretion 12.30 11.00 13 262604 344 42358374
Infusion site injury 12.29 11.00 3 262614 0 42358718
Occupational asthma 12.29 11.00 3 262614 0 42358718
Salivary gland mass 12.29 11.00 3 262614 0 42358718
Complications of transplanted kidney 12.28 11.00 9 262608 5341 42353377
Tendon calcification 12.23 11.00 7 262610 71 42358647
Liver function test abnormal 12.21 11.00 134 262483 32257 42326461
Delusion 12.20 11.00 48 262569 14686 42344032
Eosinophil count decreased 12.20 11.00 49 262568 3527 42355191
Incorrect route of product administration 12.15 11.00 214 262403 24091 42334627
Electrocardiogram QT prolonged 12.11 11.00 215 262402 47730 42310988
Hyperphosphataemia 12.09 11.00 128 262489 12876 42345842
Arthritis bacterial 12.07 11.00 11 262606 5857 42352861
Psychomotor retardation 12.06 11.00 6 262611 4393 42354325
Cardiac failure congestive 12.05 11.00 644 261973 84958 42273760
Inappropriate schedule of product administration 12.04 11.00 714 261903 95188 42263530
Forced vital capacity abnormal 12.04 11.00 4 262613 8 42358710
Nervous system neoplasm 11.99 11.00 9 262608 149 42358569
Hepatocellular carcinoma 11.97 11.00 20 262597 8174 42350544
Hypoglycaemia 11.96 11.00 279 262338 59575 42299143
Ileus 11.95 11.00 69 262548 19070 42339648
Product distribution issue 11.89 11.00 33 262584 1961 42356757
Papule 11.89 11.00 11 262606 5815 42352903
Post-traumatic stress disorder 11.88 11.00 36 262581 2249 42356469
Lung transplant 11.85 11.00 37 262580 2349 42356369
Sleep talking 11.85 11.00 17 262600 620 42358098
Personal relationship issue 11.83 11.00 12 262605 302 42358416
Eosinophilic oesophagitis 11.80 11.00 18 262599 694 42358024
Bladder discomfort 11.79 11.00 9 262608 153 42358565
Respiratory acidosis 11.76 11.00 73 262544 6258 42352460
Attention deficit hyperactivity disorder 11.75 11.00 44 262573 3064 42355654
Blebitis 11.72 11.00 4 262613 9 42358709
Skin necrosis 11.66 11.00 13 262604 6301 42352417
Epilepsy 11.65 11.00 104 262513 26067 42332651
Electrocardiogram QT shortened 11.64 11.00 9 262608 156 42358562
Testicular swelling 11.64 11.00 33 262584 1986 42356732
B-cell lymphoma 11.63 11.00 8 262609 4905 42353813
Staphylococcal sepsis 11.62 11.00 34 262583 11380 42347338
Cholecystitis 11.61 11.00 41 262576 12947 42345771
Cortisol decreased 11.59 11.00 26 262591 1352 42357366
Limb injury 11.57 11.00 137 262480 14168 42344550
Acute respiratory distress syndrome 11.57 11.00 124 262493 29984 42328734
Tumour haemorrhage 11.52 11.00 4 262613 3634 42355084
Pseudomonas bronchitis 11.52 11.00 5 262612 26 42358692
Blood urine 11.52 11.00 16 262601 566 42358152
Plasma cell myeloma 11.50 11.00 215 262402 47363 42311355
Alopecia 11.48 11.00 120 262497 29156 42329562
Emotional disorder of childhood 11.48 11.00 6 262611 50 42358668
Contraindicated product administered 11.44 11.00 100 262517 25172 42333546
Bradykinesia 11.41 11.00 10 262607 5426 42353292
Respiratory gas exchange disorder 11.34 11.00 15 262602 506 42358212
Myositis 11.33 11.00 50 262567 14816 42343902
Aortic aneurysm 11.32 11.00 84 262533 7639 42351079
Intentional device misuse 11.30 11.00 11 262606 263 42358455
Intervertebral disc degeneration 11.30 11.00 81 262536 7286 42351432
Hyperaesthesia 11.27 11.00 12 262605 5940 42352778
Eye infection 11.27 11.00 55 262562 4306 42354412
Venoocclusive disease 11.26 11.00 5 262612 3910 42354808
Neurodevelopmental disorder 11.25 11.00 14 262603 444 42358274
Malpositioned teeth 11.22 11.00 5 262612 28 42358690
Pigment dispersion syndrome 11.16 11.00 4 262613 11 42358707
Lung cyst 11.16 11.00 7 262610 85 42358633
Cryptococcosis 11.13 11.00 3 262614 3208 42355510
Intraventricular haemorrhage 11.10 11.00 5 262612 3879 42354839
Drug level above therapeutic 11.08 11.00 12 262605 5894 42352824
Transposition of the great vessels 11.08 11.00 14 262603 451 42358267
Dermatitis exfoliative 11.06 11.00 16 262601 6931 42351787
Blood albumin decreased 11.03 11.00 53 262564 15349 42343369
Parosmia 11.03 11.00 19 262598 7672 42351046
Paraneoplastic rash 11.02 11.00 7 262610 87 42358631

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 7603.86 9.89 8446 662271 241845 109676737
Dyspnoea 4169.55 9.89 15415 655302 1091457 108827125
Wheezing 3729.94 9.89 6028 664689 249202 109669380
Obstructive airways disorder 3029.67 9.89 2395 668322 43754 109874828
Cough 2919.89 9.89 7712 663005 453929 109464653
Full blood count abnormal 2461.19 9.89 2311 668406 53741 109864841
Productive cough 2177.88 9.89 3058 667659 111247 109807335
Chronic obstructive pulmonary disease 1916.23 9.89 2809 667908 106349 109812233
Sleep disorder due to a general medical condition 1747.43 9.89 1856 668861 50256 109868326
Chest discomfort 1408.23 9.89 3198 667519 170650 109747932
Sputum discoloured 1388.12 9.89 1235 669482 26710 109891872
Poor quality device used 1385.42 9.89 555 670162 2308 109916274
Forced expiratory volume decreased 1367.01 9.89 903 669814 12273 109906309
Infective pulmonary exacerbation of cystic fibrosis 1123.39 9.89 837 669880 13934 109904648
Completed suicide 1043.24 9.89 123 670594 242258 109676324
Synovitis 915.88 9.89 263 670454 273829 109644753
Off label use 821.09 9.89 5537 665180 1494648 108423934
Nasal congestion 812.08 9.89 1823 668894 96459 109822123
Pemphigus 768.20 9.89 179 670538 214391 109704191
Nasal polyps 737.61 9.89 624 670093 12576 109906006
Hand deformity 729.29 9.89 210 670507 218296 109700286
Systemic lupus erythematosus 706.30 9.89 329 670388 254009 109664573
Dyspnoea exertional 701.90 9.89 1784 668933 102276 109816306
Bronchitis 696.72 9.89 2317 668400 154715 109763867
Pneumonia 695.84 9.89 8246 662471 868468 109050114
Loss of personal independence in daily activities 665.07 9.89 2213 668504 147807 109770775
Middle insomnia 662.06 9.89 716 670001 19786 109898796
Bronchiectasis 602.49 9.89 913 669804 35580 109883002
Neutropenia 589.81 9.89 848 669869 373772 109544810
Glossodynia 580.49 9.89 311 670406 221693 109696889
Toxicity to various agents 566.94 9.89 1300 669417 479255 109439327
Blood immunoglobulin E increased 566.77 9.89 423 670294 7059 109911523
Pericarditis 549.80 9.89 323 670394 218791 109699791
Treatment failure 541.66 9.89 529 670188 276705 109641877
Impaired quality of life 540.14 9.89 782 669935 29235 109889347
Helicobacter infection 527.35 9.89 221 670496 181656 109736926
Anti-cyclic citrullinated peptide antibody positive 519.88 9.89 226 670491 181758 109736824
Arthropathy 517.59 9.89 588 670129 286934 109631648
Therapeutic product effect incomplete 515.52 9.89 2700 668017 221105 109697477
Product dose omission issue 504.27 9.89 3511 667206 318271 109600311
Breath sounds abnormal 500.28 9.89 691 670026 24713 109893869
Eosinophil count increased 471.72 9.89 610 670107 20448 109898134
Therapeutic product effect decreased 464.85 9.89 477 670240 243839 109674743
Infusion related reaction 464.18 9.89 1013 669704 380149 109538433
Rhinitis allergic 461.99 9.89 557 670160 17365 109901217
Duodenal ulcer perforation 461.50 9.89 251 670466 177449 109741133
Product quality issue 460.95 9.89 1266 669451 76033 109842549
Febrile neutropenia 455.52 9.89 762 669955 316005 109602577
Myelosuppression 445.24 9.89 33 670684 94307 109824275
Pulmonary function test decreased 438.97 9.89 388 670329 8312 109910270
Upper-airway cough syndrome 438.79 9.89 511 670206 15346 109903236
Wound 437.81 9.89 465 670252 233972 109684610
Stomatitis 418.04 9.89 619 670098 269623 109648959
Upper respiratory tract infection 412.92 9.89 1735 668982 129593 109788989
Illness 409.36 9.89 1262 669455 80909 109837673
Bronchospasm 409.19 9.89 691 670026 29548 109889034
Alopecia 398.96 9.89 1026 669691 363727 109554855
Respiratory disorder 397.06 9.89 1140 669577 70242 109848340
Cystic fibrosis 388.90 9.89 281 670436 4450 109914132
Drug abuse 385.66 9.89 306 670411 177105 109741477
Influenza 376.23 9.89 2021 668696 167080 109751502
Impaired healing 375.38 9.89 383 670334 196334 109722248
Psoriatic arthropathy 359.89 9.89 397 670320 196364 109722218
Pulmonary function test abnormal 359.49 9.89 274 670443 4726 109913856
Muscle injury 358.22 9.89 204 670513 140603 109777979
Sleep apnoea syndrome 354.01 9.89 768 669949 39679 109878903
Drug interaction 346.94 9.89 1706 669011 498477 109420105
Intentional product use issue 341.14 9.89 613 670104 247293 109671289
Pancytopenia 341.12 9.89 463 670254 209150 109709432
Haemoptysis 337.12 9.89 1076 669641 70278 109848304
Folliculitis 330.70 9.89 317 670400 167336 109751246
Drug intolerance 328.08 9.89 1310 669407 405202 109513380
Contraindicated product administered 325.63 9.89 632 670085 247635 109670947
Liver injury 324.95 9.89 261 670456 150152 109768430
Heart rate increased 323.99 9.89 1725 668992 142109 109776473
Rales 323.76 9.89 557 670160 24182 109894400
Rheumatic fever 322.85 9.89 170 670547 122409 109796173
Irritable bowel syndrome 321.01 9.89 313 670404 163902 109754680
Dermatitis atopic 318.56 9.89 563 670154 24978 109893604
Intentional overdose 317.46 9.89 206 670511 132295 109786287
Rhinorrhoea 314.67 9.89 1346 669371 101320 109817262
C-reactive protein increased 314.29 9.89 523 670194 217396 109701186
Bronchial secretion retention 310.90 9.89 252 670465 4772 109913810
Oropharyngeal pain 309.92 9.89 1630 669087 133646 109784936
Device delivery system issue 306.88 9.89 180 670537 1953 109916629
Blood test abnormal 306.53 9.89 590 670127 27964 109890618
Thrombocytopenia 306.39 9.89 1086 669631 347799 109570783
Hepatic enzyme increased 306.37 9.89 963 669754 319929 109598653
Secretion discharge 305.53 9.89 486 670231 19758 109898824
Reversible airways obstruction 300.57 9.89 188 670529 2311 109916271
Dysphonia 298.82 9.89 1077 669640 74852 109843730
Malignant neoplasm progression 282.60 9.89 387 670330 174180 109744402
Gastrooesophageal reflux disease 281.16 9.89 1963 668754 178013 109740569
Bronchopulmonary aspergillosis allergic 280.36 9.89 299 670418 8127 109910455
Emphysema 276.03 9.89 458 670259 19298 109899284
Anaemia 265.48 9.89 2085 668632 545001 109373581
Hepatic function abnormal 264.46 9.89 105 670612 89190 109829392
Food allergy 263.50 9.89 451 670266 19497 109899085
Drug ineffective 258.81 9.89 7138 663579 1513402 108405180
Asthma-chronic obstructive pulmonary disease overlap syndrome 254.50 9.89 249 670468 6095 109912487
Disease progression 253.39 9.89 704 670013 243330 109675252
Musculoskeletal stiffness 249.66 9.89 865 669852 278957 109639625
Respiratory symptom 248.21 9.89 375 670342 14570 109904012
Oxygen saturation decreased 245.64 9.89 1713 669004 155269 109763313
Platelet count decreased 245.10 9.89 657 670060 229786 109688796
Asthmatic crisis 242.28 9.89 155 670562 1987 109916595
Rheumatoid factor positive 234.79 9.89 271 670446 131369 109787213
Seasonal allergy 233.51 9.89 425 670292 19297 109899285
White blood cell count decreased 231.34 9.89 671 670046 228719 109689863
Facet joint syndrome 224.60 9.89 156 670561 96672 109821910
Sputum increased 220.09 9.89 220 670497 5531 109913051
Anxiety 219.46 9.89 3120 667597 341958 109576624
Maternal exposure during pregnancy 219.29 9.89 800 669917 254083 109664499
Abdominal discomfort 219.07 9.89 1443 669274 392415 109526167
Forced vital capacity decreased 216.51 9.89 140 670577 1830 109916752
Leukopenia 214.57 9.89 357 670360 148434 109770148
Dust allergy 214.04 9.89 221 670496 5780 109912802
Eosinophilic granulomatosis with polyangiitis 213.90 9.89 293 670424 10393 109908189
Sensitivity to weather change 208.38 9.89 280 670437 9748 109908834
Bronchial wall thickening 207.25 9.89 165 670552 3042 109915540
Joint range of motion decreased 206.47 9.89 261 670456 121571 109797011
Lip dry 204.71 9.89 183 670534 99900 109818682
Eye pruritus 202.54 9.89 544 670173 32231 109886351
Respiratory tract congestion 201.71 9.89 523 670194 30334 109888248
Chest X-ray abnormal 199.77 9.89 252 670465 8235 109910347
Respiration abnormal 199.44 9.89 271 670446 9538 109909044
Respiratory rate increased 197.88 9.89 457 670260 24626 109893956
Respiratory tract infection 195.33 9.89 907 669810 70710 109847872
Drug-induced liver injury 194.48 9.89 266 670451 119801 109798781
Inflammation 191.39 9.89 570 670147 192668 109725914
Swelling 189.74 9.89 1297 669420 349744 109568838
Hypoxia 187.39 9.89 1387 669330 128128 109790454
Coma 185.06 9.89 267 670450 117602 109800980
Pulmonary mass 183.97 9.89 571 670146 36730 109881852
Joint swelling 183.41 9.89 1758 668959 441087 109477495
Bronchial obstruction 183.30 9.89 151 670566 2928 109915654
Mucosal inflammation 182.41 9.89 188 670529 95953 109822629
Lung hyperinflation 182.32 9.89 132 670585 2097 109916485
Bronchospasm paradoxical 180.91 9.89 63 670654 158 109918424
Creatinine renal clearance decreased 179.34 9.89 404 670313 21411 109897171
Temperature regulation disorder 178.73 9.89 297 670420 12529 109906053
Cytokine release syndrome 178.58 9.89 102 670615 70204 109848378
Restrictive pulmonary disease 177.85 9.89 152 670565 3107 109915475
Lower respiratory tract infection 176.29 9.89 2251 668466 240855 109677727
Sedation complication 176.01 9.89 379 670338 19476 109899106
Cytomegalovirus infection 174.89 9.89 56 670661 54388 109864194
Blister 174.36 9.89 747 669970 226629 109691953
General physical health deterioration 172.87 9.89 1696 669021 423599 109494983
Allergy to animal 171.80 9.89 120 670597 1796 109916786
Renal impairment 171.09 9.89 578 670139 187867 109730715
Ear pain 170.18 9.89 707 670010 52519 109866063
Conjunctivitis allergic 169.86 9.89 210 670507 6721 109911861
Epilepsy 169.46 9.89 215 670502 99994 109818588
Septic shock 167.55 9.89 449 670268 157079 109761503
Swollen joint count increased 167.50 9.89 156 670561 83505 109835077
Swollen tongue 167.23 9.89 768 669949 59594 109858988
Sleep disorder due to general medical condition, insomnia type 166.15 9.89 239 670478 105404 109813178
Peak expiratory flow rate decreased 165.04 9.89 82 670635 618 109917964
Drug resistance 164.14 9.89 68 670649 56306 109862276
Acute kidney injury 163.76 9.89 2789 667928 632641 109285941
Polycystic ovaries 162.78 9.89 172 670545 4624 109913958
Swelling face 160.95 9.89 1035 669682 91286 109827296
Hypoventilation 159.38 9.89 220 670497 7861 109910721
Confusional state 158.99 9.89 1948 668769 466732 109451850
Vital capacity decreased 158.80 9.89 118 670599 1955 109916627
C-reactive protein abnormal 158.23 9.89 344 670373 129351 109789231
Nail disorder 157.54 9.89 77 670640 57858 109860724
Mite allergy 157.21 9.89 185 670532 5618 109912964
Blepharospasm 156.76 9.89 68 670649 54783 109863799
Lip swelling 154.22 9.89 663 670054 50004 109868578
Eosinophil count abnormal 152.85 9.89 90 670627 984 109917598
Headache 152.70 9.89 6674 664043 875703 109042879
Bronchial disorder 152.57 9.89 130 670587 2646 109915936
Sinusitis 152.07 9.89 2587 668130 294101 109624481
Onychomadesis 152.04 9.89 44 670673 45619 109872963
Neutrophil count decreased 151.53 9.89 316 670401 120625 109797957
Respiratory distress 147.57 9.89 815 669902 68059 109850523
Sinus pain 147.10 9.89 180 670537 5699 109912883
Therapy non-responder 146.57 9.89 477 670240 156830 109761752
Chest pain 146.41 9.89 3146 667571 373229 109545353
Drug reaction with eosinophilia and systemic symptoms 145.30 9.89 170 670547 81925 109836657
Eosinophilia 144.43 9.89 715 670002 57221 109861361
Rheumatoid arthritis 143.65 9.89 1145 669572 298468 109620114
Throat clearing 142.82 9.89 153 670564 4180 109914402
Rhonchi 142.74 9.89 156 670561 4362 109914220
Viral infection 142.71 9.89 670 670047 52469 109866113
Sinus disorder 140.65 9.89 478 670239 32250 109886332
Bone marrow failure 139.81 9.89 89 670628 57759 109860823
Suicide attempt 139.16 9.89 259 670458 103135 109815447
Nasal obstruction 139.10 9.89 134 670583 3216 109915366
Spirometry abnormal 138.67 9.89 169 670548 5328 109913254
Total lung capacity increased 136.88 9.89 162 670555 4950 109913632
Acute respiratory failure 136.31 9.89 852 669865 74408 109844174
Anaphylactic reaction 136.30 9.89 1171 669546 113129 109805453
Multiple allergies 136.07 9.89 257 670460 12006 109906576
Total lung capacity decreased 133.35 9.89 189 670528 6925 109911657
Peripheral venous disease 131.59 9.89 191 670526 83926 109834656
Sneezing 131.23 9.89 460 670257 31524 109887058
Tubulointerstitial nephritis 130.54 9.89 84 670633 54200 109864382
Hospitalisation 128.88 9.89 1377 669340 141116 109777466
Sopor 127.74 9.89 32 670685 36514 109882068
Eosinophilic bronchitis 127.47 9.89 65 670652 521 109918061
Musculoskeletal pain 126.21 9.89 625 670092 182398 109736184
Agranulocytosis 123.82 9.89 115 670602 61645 109856937
Bronchial hyperreactivity 123.68 9.89 129 670588 3415 109915167
Interstitial lung disease 123.32 9.89 432 670285 138902 109779680
Posterior reversible encephalopathy syndrome 121.60 9.89 28 670689 33833 109884749
Gastrointestinal disorder 120.94 9.89 914 669803 241038 109677544
Stress 120.27 9.89 1069 669648 104279 109814303
Lacrimation increased 119.19 9.89 436 670281 30514 109888068
Obstruction 118.59 9.89 160 670557 5592 109912990
Sensitisation 118.59 9.89 136 670581 4015 109914567
Eczema 118.44 9.89 798 669919 71495 109847087
Onychomycosis 117.93 9.89 43 670674 38488 109880094
Finger deformity 117.57 9.89 28 670689 33064 109885518
Exposure via skin contact 116.59 9.89 251 670466 12896 109905686
Incorrect dose administered 114.90 9.89 1045 669672 102596 109815986
Blood calcium decreased 114.48 9.89 476 670241 35369 109883213
Product delivery mechanism issue 112.31 9.89 46 670671 205 109918377
Cardio-respiratory arrest 112.29 9.89 345 670372 115491 109803091
Throat tightness 111.93 9.89 451 670266 33038 109885544
Gait inability 111.42 9.89 437 670280 135939 109782643
Ill-defined disorder 111.41 9.89 530 670187 156323 109762259
Liver disorder 108.59 9.89 468 670249 141775 109776807
Back pain 108.02 9.89 2981 667736 368015 109550567
Prescribed underdose 106.93 9.89 143 670574 65031 109853551
Taste disorder 106.74 9.89 144 670573 65243 109853339
Haematotoxicity 106.67 9.89 5 670712 21077 109897505
Alanine aminotransferase increased 106.29 9.89 665 670052 183108 109735474
Status asthmaticus 105.96 9.89 70 670647 951 109917631
Pharyngeal swelling 105.88 9.89 229 670488 11803 109906779
Neoplasm progression 104.69 9.89 143 670574 64452 109854130
Neuropathy peripheral 104.58 9.89 647 670070 178630 109739952
Altered state of consciousness 103.41 9.89 118 670599 57508 109861074
C-reactive protein 103.26 9.89 28 670689 30303 109888279
Blood cholesterol increased 103.12 9.89 676 670041 184109 109734473
Serotonin syndrome 103.07 9.89 124 670593 59029 109859553
No adverse event 102.95 9.89 784 669933 73055 109845527
Burning sensation 102.24 9.89 745 669972 68467 109850115
Constipation 102.23 9.89 2868 667849 354918 109563664
Toxic epidermal necrolysis 101.97 9.89 116 670601 56611 109861971
Osteoarthritis 101.96 9.89 668 670049 181955 109736627
Disseminated intravascular coagulation 101.88 9.89 62 670655 41224 109877358
Palmar-plantar erythrodysaesthesia syndrome 100.69 9.89 62 670655 40963 109877619
Decreased appetite 100.50 9.89 2160 668557 473686 109444896
Pneumocystis jirovecii pneumonia 100.23 9.89 68 670649 42667 109875915
Lung consolidation 99.86 9.89 206 670511 10270 109908312
Lung diffusion test decreased 99.84 9.89 82 670635 1583 109916999
Fibromyalgia 99.59 9.89 617 670100 170292 109748290
Blood pressure increased 98.90 9.89 2155 668562 256218 109662364
Overdose 98.85 9.89 923 669794 232871 109685711
Cerebral infarction 97.61 9.89 102 670615 51736 109866846
Orthostatic hypotension 97.23 9.89 712 670005 65537 109853045
Bacterial disease carrier 96.56 9.89 92 670625 2177 109916405
Hepatic cytolysis 96.35 9.89 115 670602 54938 109863644
Product label confusion 96.28 9.89 12 670705 22665 109895917
Increased bronchial secretion 95.76 9.89 119 670598 3829 109914753
Thrombotic microangiopathy 95.38 9.89 29 670688 29120 109889462
Pyrexia 94.27 9.89 4470 666247 893795 109024787
Neurotoxicity 93.96 9.89 71 670646 42136 109876446
Cytomegalovirus infection reactivation 93.90 9.89 4 670713 18329 109900253
Balance disorder 93.84 9.89 1101 669616 115459 109803123
Malaise 93.49 9.89 4975 665742 666844 109251738
Nasal discharge discolouration 93.35 9.89 106 670611 3095 109915487
Ear pruritus 93.08 9.89 162 670555 7098 109911484
Mycotic allergy 92.69 9.89 145 670572 5809 109912773
Therapy partial responder 92.37 9.89 55 670662 37006 109881576
Renal failure 92.18 9.89 903 669814 225671 109692911
Animal scratch 91.98 9.89 82 670635 1777 109916805
Metastases to liver 91.79 9.89 50 670667 35336 109883246
Smoke sensitivity 91.46 9.89 56 670661 661 109917921
Hepatocellular injury 90.55 9.89 104 670613 50538 109868044
Fluid retention 90.28 9.89 922 669795 93385 109825197
Total lung capacity abnormal 89.23 9.89 124 670593 4459 109914123
Transplant rejection 88.85 9.89 20 670697 24547 109894035
Drug eruption 88.78 9.89 117 670600 53542 109865040
Appendicolith 88.47 9.89 237 670480 14018 109904564
Body temperature increased 88.46 9.89 602 670115 54111 109864471
Lung opacity 88.31 9.89 209 670508 11443 109907139
Diarrhoea 88.17 9.89 5842 664875 1133663 108784919
Humidity intolerance 87.60 9.89 48 670669 452 109918130
Respiratory failure 87.56 9.89 1812 668905 213520 109705062
Wound infection 86.76 9.89 297 670420 96168 109822414
Sputum purulent 86.61 9.89 80 670637 1818 109916764
Ejection fraction 86.42 9.89 98 670619 2857 109915725
Paranasal sinus discomfort 84.84 9.89 145 670572 6260 109912322
Throat irritation 84.66 9.89 586 670131 52966 109865616
Congenital hiatus hernia 84.63 9.89 143 670574 6116 109912466
Live birth 84.15 9.89 185 670532 69299 109849283
Cerebral haemorrhage 83.71 9.89 167 670550 64801 109853781
Breast cancer stage III 82.98 9.89 227 670490 78890 109839692
Poisoning deliberate 82.96 9.89 28 670689 26303 109892279
Acute myeloid leukaemia 82.43 9.89 66 670651 38044 109880538
Lower respiratory tract congestion 82.01 9.89 122 670595 4674 109913908
Poisoning 81.72 9.89 37 670680 29068 109889514
Bronchiolitis 81.69 9.89 131 670586 5362 109913220
Rhinitis 81.32 9.89 311 670406 22234 109896348
Depressed mood 81.08 9.89 639 670078 60170 109858412
Pulmonary vasculitis 81.02 9.89 144 670573 6416 109912166
Blood lactate dehydrogenase increased 80.41 9.89 90 670627 44244 109874338
Hepatotoxicity 79.96 9.89 165 670552 63235 109855347
Cholestasis 79.61 9.89 170 670547 64348 109854234
Sciatica 78.75 9.89 291 670426 92108 109826474
Sputum abnormal 78.42 9.89 66 670651 1320 109917262
Nasal turbinate hypertrophy 78.35 9.89 54 670663 790 109917792
Aspartate aminotransferase increased 78.09 9.89 608 670109 159328 109759254
Injection site pain 77.93 9.89 1514 669203 176408 109742174
Device malfunction 77.43 9.89 334 670383 25224 109893358
Lung neoplasm malignant 76.91 9.89 407 670310 33435 109885147
Multiple drug therapy 76.88 9.89 158 670559 7856 109910726
Perfume sensitivity 76.71 9.89 59 670658 1032 109917550
Cardiotoxicity 76.61 9.89 7 670710 16874 109901708
Progressive multifocal leukoencephalopathy 76.12 9.89 28 670689 24928 109893654
Palpitations 76.02 9.89 1373 669344 157839 109760743
Neuritis 75.90 9.89 150 670567 7249 109911333
Limb injury 75.75 9.89 438 670279 37198 109881384
Forced expiratory flow decreased 75.13 9.89 37 670680 273 109918309
Hip arthroplasty 74.93 9.89 140 670577 55673 109862909
Vocal cord dysfunction 74.85 9.89 55 670662 895 109917687
Decreased activity 74.83 9.89 189 670528 10785 109907797
Adverse event 74.74 9.89 372 670345 108437 109810145
Blood pressure systolic increased 74.09 9.89 800 669917 82191 109836391
Type 2 diabetes mellitus 73.92 9.89 702 670015 176530 109742052
Sinus operation 73.90 9.89 91 670626 2900 109915682
Choking 73.30 9.89 230 670487 14880 109903702
Feeling abnormal 73.24 9.89 1520 669197 179191 109739391
Colitis 73.09 9.89 345 670372 101978 109816604
Haemophagocytic lymphohistiocytosis 72.97 9.89 51 670666 31508 109887074
Alveolar osteitis 72.64 9.89 57 670660 1028 109917554
Lower limb fracture 72.60 9.89 225 670492 75123 109843459
Myelodysplastic syndrome 72.57 9.89 72 670645 37412 109881170
Encephalopathy 71.24 9.89 252 670465 80803 109837779
Vasculitis 71.24 9.89 416 670301 35457 109883125
Airway remodelling 70.77 9.89 53 670664 889 109917693
Rash erythematous 70.37 9.89 783 669934 81049 109837533
Product dose omission in error 69.50 9.89 305 670412 23207 109895375
Cytomegalovirus viraemia 69.41 9.89 12 670705 17752 109900830
Urinary tract discomfort 68.91 9.89 53 670664 927 109917655
Knee arthroplasty 68.37 9.89 186 670531 64762 109853820
Grip strength decreased 68.00 9.89 253 670464 79921 109838661
Device deposit issue 67.97 9.89 28 670689 127 109918455
Aphonia 67.29 9.89 201 670516 12659 109905923
FEV1/FVC ratio decreased 67.15 9.89 34 670683 268 109918314
Panniculitis 66.76 9.89 8 670709 15574 109903008
Lung diffusion test abnormal 66.68 9.89 37 670680 358 109918224
Panic attack 66.42 9.89 349 670368 28591 109889991
Rash maculo-papular 66.42 9.89 229 670488 73993 109844589
Cardiac disorder 66.10 9.89 731 669986 75549 109843033
Sinus congestion 65.62 9.89 361 670356 30098 109888484
Diastolic hypotension 65.41 9.89 35 670682 313 109918269
Polyp 65.07 9.89 169 670548 9811 109908771
Increased upper airway secretion 64.81 9.89 115 670602 5117 109913465
Hepatitis 64.69 9.89 303 670414 89751 109828831
Inhalation therapy 64.53 9.89 21 670696 39 109918543
Cystic fibrosis respiratory infection suppression 64.45 9.89 39 670678 450 109918132
Superinfection 64.22 9.89 121 670596 5642 109912940
Rhabdomyolysis 63.90 9.89 447 670270 119954 109798628
Inappropriate schedule of product administration 63.13 9.89 1650 669067 201987 109716595
Shock 62.20 9.89 146 670571 53442 109865140
Pulmonary congestion 62.08 9.89 360 670357 30606 109887976
Eye swelling 61.63 9.89 377 670340 32671 109885911
Drug dependence 61.48 9.89 516 670201 49504 109869078
Injury 61.43 9.89 733 669984 176532 109742050
Multiple-drug resistance 61.39 9.89 5 670712 13230 109905352
Polyneuropathy 61.39 9.89 62 670655 31950 109886632
Right atrial hypertrophy 61.31 9.89 43 670674 648 109917934
Immunodeficiency 60.81 9.89 424 670293 38414 109880168
Proteinuria 60.51 9.89 93 670624 39925 109878657
Benign prostatic hyperplasia 60.49 9.89 245 670472 17989 109900593
Red blood cell sedimentation rate increased 60.13 9.89 257 670460 78045 109840537
Foetal death 60.08 9.89 224 670493 15821 109902761
Suspected suicide 59.97 9.89 10 670707 15189 109903393
Tumour lysis syndrome 59.82 9.89 59 670658 30742 109887840
Multiple organ dysfunction syndrome 59.45 9.89 610 670107 151100 109767482
Exposure to allergen 59.27 9.89 39 670678 526 109918056
Hypoaesthesia 59.05 9.89 1452 669265 312771 109605811
Discomfort 58.90 9.89 931 669786 213776 109704806
Exercise tolerance decreased 58.83 9.89 184 670533 11883 109906699
Respiratory syncytial virus test positive 58.74 9.89 58 670659 1436 109917146
Myalgia 58.62 9.89 1765 668952 220616 109697966
Cardiac failure 58.27 9.89 794 669923 186832 109731750
Crepitations 58.26 9.89 171 670546 10664 109907918
Cognitive disorder 58.24 9.89 798 669919 86713 109831869
Osteonecrosis of jaw 58.02 9.89 128 670589 47889 109870693
Vaginal flatulence 58.00 9.89 4 670713 12140 109906442
Hypertransaminasaemia 57.68 9.89 38 670679 24217 109894365
Human rhinovirus test positive 57.39 9.89 53 670664 1204 109917378
Atopy 57.29 9.89 51 670666 1103 109917479
Immune reconstitution inflammatory syndrome 57.11 9.89 14 670703 16212 109902370
Injection site scab 56.85 9.89 40 670677 606 109917976
Atelectasis 56.43 9.89 399 670318 36313 109882269
Tunnel vision 55.85 9.89 65 670652 1950 109916632
Lymph node calcification 55.69 9.89 35 670682 434 109918148
Hepatic failure 55.66 9.89 221 670496 68518 109850064
Drug use disorder 55.60 9.89 20 670697 18054 109900528
Neuroleptic malignant syndrome 55.59 9.89 75 670642 33984 109884598
Haematochezia 55.53 9.89 441 670276 115083 109803499
Blood parathyroid hormone decreased 55.39 9.89 7 670710 13082 109905500
Sarcoidosis 55.17 9.89 185 670532 12394 109906188
Blood iron decreased 55.10 9.89 247 670470 18967 109899615
Prolonged expiration 55.07 9.89 57 670660 1495 109917087
Arthralgia 55.01 9.89 4028 666689 775604 109142978
Graft versus host disease 54.24 9.89 23 670694 18783 109899799
Anuria 54.11 9.89 41 670676 24300 109894282
Frustration tolerance decreased 54.02 9.89 145 670572 8586 109909996
Forced expiratory volume abnormal 53.82 9.89 24 670693 137 109918445
Tremor 53.55 9.89 1606 669111 200626 109717956
Nasopharyngitis 53.47 9.89 2914 667803 391447 109527135
Anosmia 53.45 9.89 182 670535 12290 109906292
BK virus infection 53.12 9.89 8 670709 13098 109905484
Deep vein thrombosis postoperative 53.00 9.89 183 670534 59108 109859474
Infective exacerbation of chronic obstructive airways disease 52.91 9.89 80 670637 3110 109915472
Cardiac failure congestive 52.90 9.89 1244 669473 149756 109768826
Hiatus hernia 52.80 9.89 317 670400 27289 109891293
Febrile bone marrow aplasia 52.59 9.89 20 670697 17445 109901137
Circumstance or information capable of leading to medication error 52.37 9.89 105 670612 5128 109913454
Epstein-Barr virus infection 52.33 9.89 24 670693 18714 109899868
Status epilepticus 52.06 9.89 69 670648 31502 109887080
Chronic sinusitis 51.84 9.89 294 670423 24790 109893792
Hypercapnia 51.52 9.89 167 670550 10992 109907590
Hypoacusis 51.51 9.89 378 670339 34813 109883769
Nasal disorder 51.09 9.89 92 670625 4142 109914440
Malignant melanoma in situ 50.67 9.89 83 670634 3459 109915123
Hypercalcaemia 50.33 9.89 132 670585 46525 109872057
Product use issue 50.29 9.89 1472 669245 310223 109608359
Hypoalbuminaemia 50.19 9.89 61 670656 28913 109889669
Acute graft versus host disease in skin 49.98 9.89 4 670713 10736 109907846
Proctitis 49.95 9.89 20 670697 16907 109901675
Antineutrophil cytoplasmic antibody positive 49.79 9.89 101 670616 4975 109913607
Cardiac arrest 49.75 9.89 866 669851 195887 109722695
Respiratory tract inflammation 49.62 9.89 45 670672 998 109917584
Hyperbilirubinaemia 49.60 9.89 68 670649 30603 109887979
Adverse reaction 49.50 9.89 64 670653 29530 109889052
Sleep terror 49.48 9.89 118 670599 6492 109912090
Rubber sensitivity 49.46 9.89 67 670650 2351 109916231
Skin necrosis 49.42 9.89 35 670682 21477 109897105
Urticaria 49.11 9.89 2385 668332 316472 109602110
Increased viscosity of bronchial secretion 48.78 9.89 36 670681 590 109917992
Extrapyramidal disorder 48.73 9.89 62 670655 28805 109889777
Ear congestion 48.58 9.89 83 670634 3582 109915000
Metastases to bone 47.35 9.89 73 670644 31299 109887283
Pathogen resistance 47.27 9.89 24 670693 17648 109900934
Emotional distress 47.08 9.89 447 670270 44400 109874182
Oedema 46.95 9.89 944 669773 209032 109709550
Nasal inflammation 46.81 9.89 43 670674 970 109917612
Klebsiella infection 46.70 9.89 32 670685 19977 109898605
Gamma-glutamyltransferase increased 46.60 9.89 202 670515 61107 109857475
Carotid artery thrombosis 46.55 9.89 3 670714 9635 109908947
Pulmonary embolism 46.41 9.89 1663 669054 212811 109705771
Bronchomalacia 46.34 9.89 27 670690 289 109918293
Brain oedema 46.33 9.89 73 670644 31025 109887557
Chronic respiratory failure 46.06 9.89 84 670633 3819 109914763
Painful respiration 45.95 9.89 82 670635 3665 109914917
Body temperature decreased 45.92 9.89 382 670335 36553 109882029
Chronic graft versus host disease 45.51 9.89 3 670714 9454 109909128
Blood calcium increased 45.21 9.89 223 670494 17817 109900765
Joint injury 45.20 9.89 405 670312 39589 109878993
Respiratory tract irritation 45.19 9.89 37 670680 711 109917871
Dyspnoea at rest 45.14 9.89 132 670585 8214 109910368
Nasal septum deviation 45.10 9.89 61 670656 2137 109916445
Drug level increased 44.91 9.89 144 670573 47575 109871007
Angioedema 44.76 9.89 843 669874 97657 109820925
Snoring 44.35 9.89 115 670602 6669 109911913
Hyperammonaemia 44.32 9.89 14 670703 13718 109904864
Rheumatoid nodule 44.08 9.89 35 670682 20261 109898321
Cystitis haemorrhagic 44.03 9.89 10 670707 12199 109906383
Drug ineffective for unapproved indication 43.87 9.89 405 670312 102433 109816149
Product container issue 43.85 9.89 51 670666 1529 109917053
Skin toxicity 43.82 9.89 9 670708 11774 109906808
Respiratory syncytial virus infection 43.66 9.89 189 670528 14295 109904287
Nephrectomy 43.49 9.89 66 670651 2574 109916008
Enthesopathy 43.47 9.89 11 670706 12467 109906115
Venoocclusive liver disease 43.22 9.89 19 670698 15188 109903394
Blood lactic acid increased 42.85 9.89 200 670517 15621 109902961
Immune effector cell-associated neurotoxicity syndrome 42.76 9.89 18 670699 14764 109903818
Hepatitis cholestatic 42.48 9.89 27 670690 17539 109901043
Scoliosis 42.43 9.89 133 670584 8600 109909982
Bronchial neoplasm 42.16 9.89 31 670686 505 109918077
Sinusitis fungal 42.01 9.89 66 670651 2654 109915928
Sputum culture positive 41.30 9.89 80 670637 3809 109914773
Aplastic anaemia 41.25 9.89 52 670665 24256 109894326
Leukoencephalopathy 41.23 9.89 4 670713 9191 109909391
Underdose 40.99 9.89 222 670495 63332 109855250
Bradycardia 40.77 9.89 680 670037 154837 109763745
Metastases to lung 40.54 9.89 48 670669 23015 109895567
Dry skin 40.54 9.89 896 669821 106757 109811825
Product complaint 40.35 9.89 180 670537 13792 109904790
Lung diffusion disorder 40.18 9.89 24 670693 270 109918312
Exposure to toxic agent 39.94 9.89 14 670703 12844 109905738
Mucormycosis 39.77 9.89 8 670709 10620 109907962
Toxic skin eruption 39.66 9.89 66 670651 27449 109891133
Gout 39.65 9.89 367 670350 36199 109882383
Nephropathy toxic 39.53 9.89 66 670651 27412 109891170
Aspirin-exacerbated respiratory disease 39.51 9.89 38 670679 910 109917672
Hypothyroidism 39.24 9.89 641 670076 72258 109846324
Bladder pain 39.14 9.89 65 670652 2740 109915842
Metabolic acidosis 39.09 9.89 401 670316 99343 109819239
Diffuse large B-cell lymphoma 39.05 9.89 24 670693 15874 109902708
Transplant dysfunction 39.04 9.89 3 670714 8325 109910257
Spinal muscular atrophy 38.89 9.89 27 670690 400 109918182
Product use in unapproved indication 38.87 9.89 2268 668449 445109 109473473
Right ventricular hypertrophy 38.82 9.89 50 670667 1669 109916913
Rhinovirus infection 38.78 9.89 158 670559 11631 109906951
Foreign body in reproductive tract 38.64 9.89 38 670679 936 109917646
Back injury 38.62 9.89 152 670565 47247 109871335
Gastrointestinal toxicity 38.50 9.89 10 670707 11138 109907444
Carpal tunnel syndrome 38.48 9.89 252 670465 22358 109896224
Hyperhidrosis 38.27 9.89 1443 669274 185855 109732727
Ataxia 38.26 9.89 78 670639 30030 109888552
Analgesic therapy 38.25 9.89 114 670603 7170 109911412
Pulmonary toxicity 38.05 9.89 31 670686 17715 109900867
Skin discomfort 38.00 9.89 55 670662 2055 109916527
Lymphopenia 37.96 9.89 121 670596 40049 109878533
Appendicitis 37.88 9.89 299 670418 28165 109890417
Salpingo-oophorectomy unilateral 37.87 9.89 35 670682 796 109917786
Bradyphrenia 37.78 9.89 12 670705 11716 109906866
Peritonitis 37.71 9.89 89 670628 32518 109886064
Dermatitis exfoliative generalised 37.59 9.89 10 670707 10962 109907620
Wall motion score index abnormal 37.51 9.89 35 670682 806 109917776
Mood altered 37.46 9.89 240 670477 21135 109897447
Blood phosphorus increased 37.46 9.89 197 670520 16143 109902439
Arteriosclerosis coronary artery 37.45 9.89 271 670446 24847 109893735
Blood immunoglobulin E decreased 37.43 9.89 21 670696 208 109918374
Pulmonary hypertension 37.34 9.89 505 670212 54715 109863867
Infection 37.32 9.89 1805 668912 360395 109558187
Depression 37.27 9.89 2315 668402 315020 109603562
Death 37.23 9.89 3691 667026 695178 109223404
Rib fracture 37.16 9.89 340 670377 33430 109885152
Blood creatinine increased 37.15 9.89 835 669882 182054 109736528
Cockroach allergy 37.03 9.89 17 670700 105 109918477
Renal tubular necrosis 37.01 9.89 81 670636 30394 109888188
Pharyngeal oedema 36.94 9.89 197 670520 16231 109902351
Hyperkalaemia 36.84 9.89 590 670127 135206 109783376
Crying 36.78 9.89 274 670443 25354 109893228
Product taste abnormal 36.78 9.89 60 670657 2492 109916090
Disorientation 36.70 9.89 264 670453 70407 109848175
Cytopenia 36.62 9.89 80 670637 30036 109888546
Ejection fraction abnormal 36.53 9.89 71 670646 3389 109915193
Hypocalcaemia 36.51 9.89 239 670478 65127 109853455
Pruritus 36.49 9.89 4045 666672 577515 109341067
Aplasia 36.45 9.89 3 670714 7870 109910712
Drug therapy 36.31 9.89 112 670605 7179 109911403
Sputum retention 36.28 9.89 43 670674 1316 109917266
Blood potassium decreased 36.22 9.89 494 670223 53620 109864962
Mixed liver injury 36.09 9.89 14 670703 12065 109906517
Colorectal cancer 35.95 9.89 6 670711 9108 109909474
Carbon dioxide increased 35.86 9.89 63 670654 2781 109915801
Micturition urgency 35.77 9.89 220 670497 19100 109899482
Basal cell carcinoma 35.74 9.89 147 670570 45123 109873459
Overlap syndrome 35.66 9.89 6 670711 9053 109909529
Burns second degree 35.65 9.89 3 670714 7730 109910852
Kidney transplant rejection 35.64 9.89 14 670703 11973 109906609
Hyperthermia 35.58 9.89 46 670671 21226 109897356
Eye irritation 35.40 9.89 334 670383 33118 109885464
Akathisia 35.33 9.89 31 670686 17082 109901500
Metastases to lymph nodes 35.14 9.89 24 670693 15008 109903574
Nausea 34.37 9.89 6792 663925 1228898 108689684
Viral test positive 34.36 9.89 34 670683 844 109917738
Somnolence 34.36 9.89 1464 669253 295985 109622597
Hepatitis B reactivation 34.24 9.89 3 670714 7481 109911101
Uveitis 34.24 9.89 49 670668 21661 109896921
Eosinophilic oesophagitis 34.18 9.89 41 670676 1271 109917311
Malignant mediastinal neoplasm 34.17 9.89 42 670675 1336 109917246
Enterococcal infection 34.11 9.89 44 670673 20322 109898260
Dry mouth 34.08 9.89 937 669780 199011 109719571
Central nervous system mass 33.95 9.89 33 670684 801 109917781
Ear infection 33.92 9.89 552 670165 62180 109856402
Mast cell activation syndrome 33.81 9.89 44 670673 1484 109917098
Oesophageal spasm 33.67 9.89 71 670646 3595 109914987
Seronegative arthritis 33.63 9.89 19 670698 13158 109905424
Hyper IgE syndrome 33.62 9.89 30 670687 651 109917931
Victim of child abuse 33.46 9.89 39 670678 1172 109917410
Rebound nasal congestion 33.44 9.89 13 670704 49 109918533
COVID-19 33.42 9.89 1812 668905 243248 109675334
Toxic encephalopathy 33.34 9.89 26 670691 15188 109903394
Hypercholesterolaemia 33.26 9.89 371 670346 90466 109828116
Graft versus host disease in gastrointestinal tract 33.04 9.89 7 670710 8961 109909621
Mouth swelling 33.01 9.89 109 670608 7245 109911337
Cardiac septal defect 32.97 9.89 35 670682 946 109917636
Oliguria 32.62 9.89 39 670678 18618 109899964
Wrong technique in device usage process 32.52 9.89 104 670613 6797 109911785
Diastolic dysfunction 32.28 9.89 155 670562 12249 109906333
Nicotine dependence 32.09 9.89 40 670677 1291 109917291
Personality disorder 32.06 9.89 19 670698 12818 109905764
Forced expiratory volume increased 32.05 9.89 16 670701 122 109918460
Medication error 31.95 9.89 448 670269 104918 109813664
Respiratory gas exchange disorder 31.90 9.89 33 670684 865 109917717
Cardiac murmur 31.84 9.89 257 670460 24371 109894211
Tenosynovitis 31.84 9.89 31 670686 16252 109902330
Ear discomfort 31.80 9.89 144 670573 11105 109907477
Weight decreased 31.78 9.89 3273 667444 464784 109453798
Hyposmia 31.69 9.89 37 670680 1114 109917468
Coordination abnormal 31.52 9.89 66 670651 25162 109893420
Increased viscosity of upper respiratory secretion 31.51 9.89 28 670689 604 109917978
Hemiparesis 31.36 9.89 148 670569 43755 109874827
Factitious disorder 31.35 9.89 18 670699 187 109918395
Anger 31.24 9.89 210 670507 18797 109899785
Myotonia 31.15 9.89 20 670697 258 109918324
Hypertensive crisis 31.09 9.89 63 670654 24309 109894273
Acute hepatic failure 30.97 9.89 115 670602 36353 109882229
Injection site swelling 30.95 9.89 537 670180 61253 109857329
Substance use disorder 30.60 9.89 4 670713 7286 109911296
Joint destruction 30.58 9.89 14 670703 10929 109907653
Respiratory acidosis 30.54 9.89 165 670552 13661 109904921
Pregnancy 30.44 9.89 183 670534 50884 109867698
Use of accessory respiratory muscles 30.41 9.89 29 670688 687 109917895
Epidural lipomatosis 30.33 9.89 49 670668 2018 109916564
Bronchopulmonary aspergillosis 30.33 9.89 87 670630 29776 109888806
Vision blurred 30.30 9.89 1010 669707 128012 109790570
Macular degeneration 30.26 9.89 53 670664 21606 109896976
Broncholithiasis 30.26 9.89 20 670697 272 109918310
Pneumonia haemophilus 30.25 9.89 57 670660 2658 109915924
Parathyroid gland enlargement 30.17 9.89 18 670699 202 109918380
Lower respiratory tract infection bacterial 30.08 9.89 35 670682 1050 109917532
Eosinophil count 29.82 9.89 17 670700 174 109918408
Cytomegalovirus chorioretinitis 29.71 9.89 4 670713 7124 109911458
Enterocolitis 29.66 9.89 43 670674 18906 109899676
Ventilation perfusion mismatch 29.60 9.89 30 670687 767 109917815
Graft versus host disease in skin 29.29 9.89 7 670710 8247 109910335
Hyperprolactinaemia 29.12 9.89 3 670714 6572 109912010
Intervertebral discitis 28.95 9.89 4 670713 6986 109911596
Oxygen consumption increased 28.94 9.89 88 670629 5597 109912985
Psychomotor retardation 28.88 9.89 6 670711 7786 109910796
Pickwickian syndrome 28.77 9.89 25 670692 523 109918059
Endometrial ablation 28.68 9.89 32 670685 916 109917666
Skin laceration 28.57 9.89 322 670395 33431 109885151
Musculoskeletal chest pain 28.55 9.89 284 670433 28563 109890019
Terminal insomnia 28.52 9.89 46 670671 1892 109916690
Sedation 28.50 9.89 587 670130 69096 109849486
Delirium 28.41 9.89 613 670104 134412 109784170
Injection site reaction 28.34 9.89 375 670342 88695 109829887
Distal intestinal obstruction syndrome 28.30 9.89 33 670684 992 109917590
Impaired work ability 28.30 9.89 75 670642 26344 109892238
Pneumothorax 28.25 9.89 333 670384 34952 109883630
Feeling cold 28.22 9.89 323 670394 33664 109884918
Wolff-Parkinson-White syndrome 28.17 9.89 22 670695 394 109918188
Sinus polyp 28.16 9.89 27 670690 644 109917938
Diabetes mellitus 28.15 9.89 796 669921 98585 109819997
Intentional self-injury 28.03 9.89 124 670593 37305 109881277
Aspiration 28.02 9.89 296 670421 30237 109888345
Factor V Leiden mutation 27.98 9.89 19 670698 271 109918311
Lymphoproliferative disorder 27.93 9.89 5 670712 7213 109911369
Idiopathic intracranial hypertension 27.93 9.89 69 670648 3883 109914699
Bacteraemia 27.93 9.89 147 670570 42243 109876339
Nervousness 27.86 9.89 344 670373 36507 109882075
Influenza B virus test positive 27.80 9.89 22 670695 402 109918180
Eosinophil count decreased 27.73 9.89 90 670627 5928 109912654
Polymyalgia rheumatica 27.60 9.89 94 670623 6348 109912234
Escherichia infection 27.55 9.89 65 670652 23751 109894831
Gastroenteritis viral 27.40 9.89 300 670417 30926 109887656
Stridor 27.28 9.89 98 670619 6797 109911785
Sinonasal obstruction 27.27 9.89 21 670696 368 109918214
Aplasia pure red cell 27.17 9.89 12 670705 9566 109909016
Cholecystitis chronic 27.15 9.89 122 670595 9378 109909204
Cytomegalovirus colitis 27.09 9.89 5 670712 7056 109911526
Squamous cell carcinoma of skin 26.96 9.89 39 670678 17164 109901418
Hypertriglyceridaemia 26.95 9.89 35 670682 16119 109902463
Multiple sclerosis relapse 26.91 9.89 186 670531 50054 109868528
Drug hypersensitivity 26.89 9.89 2379 668338 451711 109466871
Angle closure glaucoma 26.78 9.89 63 670654 3436 109915146
Rib deformity 26.77 9.89 17 670700 215 109918367
Ischaemic stroke 26.68 9.89 144 670573 41119 109877463
Gangrene 26.65 9.89 36 670681 16305 109902277
Enteritis 26.65 9.89 47 670670 19109 109899473
Fractional exhaled nitric oxide increased 26.64 9.89 28 670689 748 109917834
Rhinitis perennial 26.63 9.89 17 670700 217 109918365
Wrist fracture 26.59 9.89 164 670553 14253 109904329
Coagulation factor V level abnormal 26.53 9.89 15 670702 151 109918431
Neutropenic colitis 26.43 9.89 8 670709 8057 109910525
Forced expiratory volume 26.39 9.89 13 670704 96 109918486
Osteoporosis 26.36 9.89 704 670013 86448 109832134
Tympanosclerosis 26.18 9.89 11 670706 53 109918529
Extra dose administered 26.12 9.89 144 670573 12015 109906567
Liver function test increased 25.96 9.89 379 670338 88169 109830413
Haemolytic anaemia 25.91 9.89 55 670662 20865 109897717
Hyperuricaemia 25.80 9.89 30 670687 14501 109904081
Neurodevelopmental disorder 25.76 9.89 12 670705 77 109918505
Generalised tonic-clonic seizure 25.69 9.89 210 670507 54470 109864112
Upper respiratory fungal infection 25.54 9.89 21 670696 406 109918176
Brain scan abnormal 25.49 9.89 39 670678 1532 109917050
Road traffic accident 25.47 9.89 478 670239 106920 109811662
Second primary malignancy 25.44 9.89 44 670673 18024 109900558
Subdural haematoma 25.39 9.89 124 670593 36330 109882252
Drug level decreased 25.36 9.89 46 670671 18502 109900080
Transient ischaemic attack 25.20 9.89 536 670181 63446 109855136
Diffuse large B-cell lymphoma recurrent 25.18 9.89 4 670713 6295 109912287
Acute respiratory distress syndrome 25.13 9.89 204 670513 52994 109865588
Nystagmus 25.10 9.89 20 670697 11557 109907025
Pharyngitis streptococcal 25.10 9.89 152 670565 13125 109905457
Periorbital swelling 25.07 9.89 82 670635 5423 109913159
Wrong patient received product 25.02 9.89 5 670712 6669 109911913
Dermatitis acneiform 25.02 9.89 24 670693 12671 109905911
Stress cardiomyopathy 25.00 9.89 173 670544 15633 109902949
Tracheomalacia 24.99 9.89 25 670692 629 109917953
Skin ulcer 24.89 9.89 256 670461 63389 109855193
Accidental overdose 24.84 9.89 198 670519 51636 109866946
Abnormal behaviour 24.76 9.89 353 670364 38686 109879896
Ventricular failure 24.64 9.89 23 670694 530 109918052
Miosis 24.63 9.89 61 670656 21922 109896660
Pseudomonal sepsis 24.63 9.89 12 670705 9034 109909548
Cystic fibrosis related diabetes 24.62 9.89 16 670701 211 109918371
Fracture 24.61 9.89 73 670644 24715 109893867
Ileus paralytic 24.55 9.89 21 670696 11716 109906866
Sleep disorder therapy 24.48 9.89 100 670617 7371 109911211
Croup infectious 24.43 9.89 31 670686 1019 109917563
Drug effective for unapproved indication 24.36 9.89 30 670687 14137 109904445
Arthritis bacterial 24.34 9.89 18 670699 10802 109907780
Nocturnal dyspnoea 24.25 9.89 42 670675 1833 109916749
Inappropriate antidiuretic hormone secretion 24.25 9.89 114 670603 33737 109884845
Blood creatine phosphokinase increased 24.24 9.89 305 670412 72772 109845810
Nephrotic syndrome 24.08 9.89 29 670688 13802 109904780
Peripheral sensory neuropathy 24.05 9.89 40 670677 16640 109901942
Infusion site reaction 24.04 9.89 44 670673 17638 109900944
Right atrial enlargement 24.03 9.89 22 670695 494 109918088
Haemoglobin decreased 23.97 9.89 1248 669469 247479 109671103
Vaginal discharge 23.96 9.89 45 670672 17863 109900719
Rectal prolapse 23.96 9.89 50 670667 2513 109916069
Acute graft versus host disease in intestine 23.90 9.89 3 670714 5636 109912946
Pneumothorax spontaneous 23.89 9.89 41 670676 1776 109916806
Gastric cancer 23.89 9.89 19 670698 10989 109907593
Functional residual capacity increased 23.87 9.89 12 670705 93 109918489
Intercepted product preparation error 23.78 9.89 6 670711 6814 109911768
Brain abscess 23.54 9.89 6 670711 6768 109911814
Scratch 23.53 9.89 147 670570 12832 109905750
Vascular shunt 23.50 9.89 10 670707 50 109918532
Antacid therapy 23.48 9.89 80 670637 5404 109913178
Coagulation factor deficiency 23.44 9.89 18 670699 314 109918268
Small airways disease 23.43 9.89 11 670706 72 109918510
Colitis ulcerative 23.43 9.89 329 670388 77034 109841548
Colitis microscopic 23.41 9.89 28 670689 13366 109905216
Aphthous ulcer 23.41 9.89 59 670658 21077 109897505
FEV1/FVC ratio abnormal 23.34 9.89 10 670707 51 109918531
Bronchial haemorrhage 23.31 9.89 35 670682 1352 109917230
CFTR gene mutation 23.28 9.89 16 670701 233 109918349
Jaundice 23.27 9.89 238 670479 58998 109859584
Ageusia 23.27 9.89 201 670516 19444 109899138
Muscle tension dysphonia 23.22 9.89 17 670700 275 109918307
Seizure 23.21 9.89 1100 669617 220085 109698497
Myoclonus 23.12 9.89 112 670605 32886 109885696
Product administration interrupted 23.10 9.89 132 670585 11160 109907422
Influenza like illness 23.09 9.89 701 670016 87711 109830871
Hyperpyrexia 23.06 9.89 10 670707 8059 109910523
Distributive shock 23.04 9.89 4 670713 5900 109912682
Haemodynamic instability 23.01 9.89 67 670650 22821 109895761
Insurance issue 23.01 9.89 126 670591 10486 109908096
Insomnia 22.98 9.89 2511 668206 358079 109560503
Bladder cancer 22.98 9.89 56 670661 20236 109898346
Autoimmune disorder 22.97 9.89 270 670447 65213 109853369
Cholestatic liver injury 22.97 9.89 8 670709 7368 109911214
Hepatitis B 22.94 9.89 15 670702 9597 109908985
Endometriosis 22.92 9.89 68 670649 4266 109914316
Paranasal sinus hypersecretion 22.91 9.89 71 670646 4563 109914019
Choking sensation 22.89 9.89 69 670648 4367 109914215
Obesity 22.87 9.89 518 670199 112833 109805749
Atrial fibrillation 22.81 9.89 1652 669065 227990 109690592
Anticoagulant therapy 22.77 9.89 78 670639 5283 109913299
Oxygen therapy 22.77 9.89 66 670651 4087 109914495
Catarrh 22.76 9.89 8 670709 7327 109911255
Nasal turbinate abnormality 22.74 9.89 9 670708 36 109918546
Oropharyngeal discomfort 22.65 9.89 123 670594 10204 109908378
Pemphigoid 22.62 9.89 54 670663 19653 109898929
Drug dose omission by device 22.44 9.89 158 670559 14358 109904224
Oxygen saturation abnormal 22.41 9.89 80 670637 5531 109913051
Heart sounds 22.37 9.89 31 670686 1112 109917470
Ovarian hyperstimulation syndrome 22.36 9.89 3 670714 5357 109913225
Mobility decreased 22.36 9.89 1194 669523 236228 109682354
Red blood cell sedimentation rate abnormal 22.34 9.89 75 670642 24434 109894148
Expiratory reserve volume decreased 22.32 9.89 13 670704 139 109918443
Rash macular 22.27 9.89 344 670373 38342 109880240
Suffocation feeling 22.19 9.89 43 670674 2048 109916534
Capillaritis 22.13 9.89 47 670670 2392 109916190
Complication of device removal 22.11 9.89 70 670647 4550 109914032
Cervix neoplasm 21.91 9.89 14 670703 179 109918403
Infusion site swelling 21.90 9.89 118 670599 9759 109908823
Normochromic normocytic anaemia 21.90 9.89 145 670572 12912 109905670
Cholangitis 21.90 9.89 41 670676 16294 109902288
Cor pulmonale 21.74 9.89 45 670672 2249 109916333
Haemorrhage intracranial 21.68 9.89 96 670621 28873 109889709
Myocarditis 21.65 9.89 101 670616 29954 109888628
Decreased bronchial secretion 21.62 9.89 10 670707 63 109918519
Asthma exercise induced 21.62 9.89 15 670702 222 109918360
Blood cholesterol 21.58 9.89 27 670690 875 109917707
Nasal mucosal disorder 21.56 9.89 40 670677 1843 109916739
Clostridium difficile colitis 21.55 9.89 166 670551 43612 109874970
Occupational asthma 21.51 9.89 7 670710 13 109918569
Bronchial irritation 21.49 9.89 10 670707 64 109918518
Oesophageal polyp 21.48 9.89 11 670706 89 109918493
Respiratory syncytial virus bronchiolitis 21.48 9.89 25 670692 750 109917832
Hypersensitivity 21.47 9.89 2781 667936 401217 109517365
Breast conserving surgery 21.46 9.89 27 670690 880 109917702
Radiculopathy 21.40 9.89 54 670663 19282 109899300
Metastases to central nervous system 21.37 9.89 69 670648 22748 109895834
Pharyngeal erythema 21.36 9.89 44 670673 2191 109916391
Exposure during pregnancy 21.26 9.89 815 669902 166609 109751973
Cross sensitivity reaction 21.23 9.89 4 670713 5563 109913019
Unintentional medical device removal 21.19 9.89 14 670703 8909 109909673
Appetite disorder 21.19 9.89 116 670601 9653 109908929
Acute myeloid leukaemia recurrent 21.15 9.89 3 670714 5136 109913446
Eye allergy 21.14 9.89 29 670688 1030 109917552
Intervertebral disc protrusion 21.13 9.89 259 670458 27439 109891143
Cerebral artery thrombosis 21.10 9.89 37 670680 1631 109916951
Immune thrombocytopenia 21.08 9.89 68 670649 22426 109896156
Eosinophilic myocarditis 21.06 9.89 42 670675 2043 109916539
Drug tolerance 21.05 9.89 43 670674 16542 109902040
Osteomyelitis 20.86 9.89 133 670584 36467 109882115
Infusion site erythema 20.79 9.89 134 670583 11825 109906757
Wound secretion 20.76 9.89 90 670627 6811 109911771
Pneumonia aspiration 20.69 9.89 357 670360 80876 109837706
Nasal pruritus 20.69 9.89 27 670690 913 109917669
Pneumonia viral 20.63 9.89 127 670590 11030 109907552
Central obesity 20.55 9.89 41 670676 1995 109916587
Sepsis 20.55 9.89 1707 669010 325639 109592943
Scleritis 20.45 9.89 4 670713 5416 109913166
Separation anxiety disorder 20.41 9.89 8 670709 31 109918551
Embolism venous 20.39 9.89 72 670645 4951 109913631
Hypothermia 20.39 9.89 86 670631 26216 109892366
Upper limb fracture 20.36 9.89 205 670512 20683 109897899
Blood alkaline phosphatase increased 20.32 9.89 305 670412 70630 109847952
Adenovirus infection 20.29 9.89 22 670695 10972 109907610
Duodenal ulcer repair 20.28 9.89 10 670707 74 109918508
Condition aggravated 20.25 9.89 4040 666677 730796 109187786
Inspiratory capacity abnormal 20.22 9.89 11 670706 102 109918480
Pustular psoriasis 20.20 9.89 32 670685 13573 109905009
Exposure to fungus 20.13 9.89 14 670703 208 109918374
Dermatitis allergic 20.12 9.89 211 670506 21513 109897069
Mydriasis 20.07 9.89 68 670649 22089 109896493
Gingival bleeding 20.00 9.89 58 670659 19781 109898801
Nonspecific reaction 19.98 9.89 52 670665 3022 109915560
Peak expiratory flow rate abnormal 19.95 9.89 11 670706 105 109918477
Mechanical ventilation complication 19.93 9.89 24 670693 747 109917835
Affect lability 19.89 9.89 53 670664 18584 109899998
Encephalitis 19.79 9.89 54 670663 18785 109899797
Bronchitis bacterial 19.78 9.89 38 670679 1798 109916784
Frequent bowel movements 19.75 9.89 309 670408 71081 109847501
Neurological symptom 19.71 9.89 162 670555 15446 109903136
Erythema multiforme 19.62 9.89 64 670653 21033 109897549
Multimorbidity 19.59 9.89 34 670683 1486 109917096
Upper respiratory tract congestion 19.58 9.89 51 670666 2966 109915616
Tumour haemorrhage 19.52 9.89 4 670713 5241 109913341
Ischaemic contracture of the left ventricle 19.43 9.89 12 670705 144 109918438
Tongue biting 19.40 9.89 50 670667 2889 109915693
Soft tissue mass 19.38 9.89 34 670683 1499 109917083
Therapeutic response shortened 19.37 9.89 269 670448 29314 109889268
Catatonia 19.35 9.89 24 670693 11276 109907306
Pneumonia cytomegaloviral 19.28 9.89 9 670708 6945 109911637
Endophthalmitis 19.23 9.89 13 670704 8174 109910408
Product administered to patient of inappropriate age 19.19 9.89 98 670619 7938 109910644
Anal fistula 19.18 9.89 14 670703 8459 109910123
Hepatitis toxic 19.18 9.89 6 670711 5915 109912667
Alanine aminotransferase abnormal 19.16 9.89 17 670700 9317 109909265
Alcohol poisoning 19.04 9.89 16 670701 9004 109909578
Infective exacerbation of bronchiectasis 19.03 9.89 25 670692 851 109917731
Retching 19.03 9.89 216 670501 22466 109896116
Skin candida 19.01 9.89 43 670674 2285 109916297
Blood pressure fluctuation 19.01 9.89 329 670388 74495 109844087
PCO2 increased 18.99 9.89 39 670678 1938 109916644
Electrocardiogram QRS complex prolonged 18.99 9.89 31 670686 12990 109905592
Neurological decompensation 18.94 9.89 9 670708 6874 109911708
Aphasia 18.91 9.89 248 670469 58749 109859833
Acute sinusitis 18.89 9.89 72 670645 5139 109913443
Vocal cord disorder 18.83 9.89 36 670681 1697 109916885
Visual acuity reduced 18.81 9.89 116 670601 32057 109886525
Kyphosis 18.79 9.89 52 670665 3135 109915447
Eosinophilic pneumonia chronic 18.65 9.89 20 670697 547 109918035
Anal abscess 18.62 9.89 26 670691 11612 109906970
Complications of transplanted kidney 18.61 9.89 11 670706 7431 109911151
Acute generalised exanthematous pustulosis 18.60 9.89 68 670649 21596 109896986
Streptococcal sepsis 18.60 9.89 4 670713 5068 109913514
Sinus tachycardia 18.59 9.89 376 670341 44117 109874465
Autoimmune haemolytic anaemia 18.57 9.89 22 670695 10545 109908037
Bacterial infection 18.56 9.89 387 670330 45649 109872933
Acute lymphocytic leukaemia recurrent 18.50 9.89 6 670711 5781 109912801
Herpes zoster 18.43 9.89 508 670209 107871 109810711
Breast cancer stage I 18.36 9.89 11 670706 7376 109911206
Musculoskeletal discomfort 18.34 9.89 221 670496 23317 109895265
Pulmonary tuberculosis 18.34 9.89 17 670700 9122 109909460
Amniotic fluid index increased 18.27 9.89 10 670707 94 109918488
Self-injurious ideation 18.26 9.89 63 670654 4283 109914299
Device expulsion 18.25 9.89 111 670606 30780 109887802
Hilar lymphadenopathy 18.22 9.89 42 670675 2260 109916322
Sinus polyp degeneration 18.21 9.89 9 670708 67 109918515
Uterine perforation 18.18 9.89 86 670631 6754 109911828
Concussion 18.08 9.89 126 670591 11412 109907170
Paraparesis 18.03 9.89 3 670714 4563 109914019
Dysarthria 17.96 9.89 381 670336 83740 109834842
Rash 17.93 9.89 4564 666153 816400 109102182
Proctalgia 17.89 9.89 33 670684 13189 109905393
Body mass index increased 17.88 9.89 42 670675 2288 109916294
Lipodystrophy acquired 17.80 9.89 3 670714 4521 109914061
Hypervolaemia 17.78 9.89 409 670308 49051 109869531
Stoma closure 17.78 9.89 17 670700 404 109918178
Functional residual capacity decreased 17.77 9.89 9 670708 71 109918511
Infusion site bruising 17.71 9.89 56 670661 3638 109914944
Carcinoid tumour pulmonary 17.68 9.89 17 670700 407 109918175
Pancreatic carcinoma 17.68 9.89 40 670677 14832 109903750
Laryngeal stenosis 17.67 9.89 31 670686 1367 109917215
Shock haemorrhagic 17.66 9.89 95 670622 27152 109891430
Influenza immunisation 17.64 9.89 5 670712 4 109918578
Adverse drug reaction 17.64 9.89 496 670221 105063 109813519
Metastases to peritoneum 17.61 9.89 6 670711 5604 109912978
Osteonecrosis 17.54 9.89 126 670591 33615 109884967
Pleuritic pain 17.50 9.89 162 670555 15978 109902604
Device defective 17.47 9.89 57 670660 3765 109914817
Lip discolouration 17.46 9.89 23 670694 785 109917797
Eye disorder 17.39 9.89 259 670458 28647 109889935
Stevens-Johnson syndrome 17.39 9.89 191 670526 46710 109871872
Pulmonary pain 17.37 9.89 80 670637 6213 109912369
Fungal disease carrier 17.33 9.89 18 670699 474 109918108
Femur fracture 17.33 9.89 179 670538 44290 109874292
Attention-seeking behaviour 17.33 9.89 10 670707 105 109918477
Pneumonia pseudomonal 17.31 9.89 91 670626 7455 109911127
Burns third degree 17.30 9.89 18 670699 475 109918107
Myositis 17.26 9.89 114 670603 31002 109887580
Temperature intolerance 17.19 9.89 144 670573 13806 109904776
Eosinophilic pneumonia 17.17 9.89 88 670629 7139 109911443
Tachypnoea 17.15 9.89 335 670382 39060 109879522
Lymphocyte count decreased 17.13 9.89 244 670473 56999 109861583
Hepatitis fulminant 17.08 9.89 16 670701 8544 109910038
Paraesthesia 17.05 9.89 1444 669273 275077 109643505
Prescription drug used without a prescription 17.05 9.89 6 670711 5490 109913092
Metastasis 17.04 9.89 15 670702 8252 109910330
Meningitis cryptococcal 16.97 9.89 4 670713 4758 109913824
Granulocytopenia 16.97 9.89 32 670685 12683 109905899
Deformity 16.96 9.89 22 670695 10138 109908444
Substance abuse 16.96 9.89 31 670686 12432 109906150
Bronchitis chronic 16.88 9.89 67 670650 4873 109913709
Tongue injury 16.88 9.89 20 670697 612 109917970
Female genital tract fistula 16.87 9.89 48 670669 16471 109902111
Subileus 16.83 9.89 9 670708 6428 109912154
Sensation of foreign body 16.83 9.89 94 670623 7881 109910701
Haemophilus infection 16.82 9.89 46 670671 2754 109915828
Erysipelas 16.80 9.89 34 670683 13124 109905458
Ligament sprain 16.79 9.89 160 670557 15908 109902674
Hysterectomy 16.70 9.89 95 670622 8019 109910563
Device related infection 16.69 9.89 156 670561 39363 109879219
Otorrhoea 16.69 9.89 40 670677 2208 109916374
Quadriparesis 16.69 9.89 4 670713 4703 109913879
Coagulopathy 16.64 9.89 163 670554 40748 109877834
Complication of device insertion 16.59 9.89 101 670616 8737 109909845
Ejection fraction decreased 16.58 9.89 163 670554 40717 109877865
Paronychia 16.52 9.89 26 670691 11055 109907527
Dysphemia 16.51 9.89 58 670659 3979 109914603
Pneumonia lipoid 16.50 9.89 12 670705 192 109918390
Infusion site mass 16.49 9.89 34 670683 1694 109916888
Encephalitis toxic 16.47 9.89 14 670703 284 109918298
Ear disorder 16.46 9.89 66 670651 4823 109913759
Asthma prophylaxis 16.45 9.89 4 670713 0 109918582
Labelled drug-drug interaction medication error 16.43 9.89 107 670610 29195 109889387
Venoocclusive disease 16.43 9.89 9 670708 6341 109912241
Cardiac tamponade 16.41 9.89 27 670690 11280 109907302
Electrocardiogram U-wave abnormality 16.40 9.89 9 670708 85 109918497
Subarachnoid haemorrhage 16.38 9.89 109 670608 29593 109888989
Escherichia sepsis 16.38 9.89 23 670694 10249 109908333
Red blood cell count decreased 16.38 9.89 291 670426 65632 109852950
Lung disorder 16.33 9.89 1286 669431 178761 109739821
Cryptococcosis 16.29 9.89 4 670713 4627 109913955
Attention deficit hyperactivity disorder 16.24 9.89 62 670655 4429 109914153
Infusion site haemorrhage 16.23 9.89 63 670654 4535 109914047
Guillain-Barre syndrome 16.21 9.89 25 670692 10719 109907863
Cerebellar syndrome 16.21 9.89 9 670708 6293 109912289
Familial periodic paralysis 16.13 9.89 15 670702 344 109918238
Intentional device misuse 16.06 9.89 23 670694 851 109917731
Disease complication 16.03 9.89 74 670643 5753 109912829
Aortic aneurysm 16.02 9.89 109 670608 9795 109908787
Hypoproteinaemia 16.01 9.89 8 670709 5937 109912645
Hyperlipidaemia 16.00 9.89 306 670411 35542 109883040
Hypermetropia 16.00 9.89 17 670700 460 109918122
General symptom 15.99 9.89 18 670699 8828 109909754
Mycobacterial infection 15.99 9.89 61 670656 4356 109914226
Vaccination site haemorrhage 15.98 9.89 7 670710 38 109918544
Rectal haemorrhage 15.95 9.89 580 670137 119253 109799329
Tracheal disorder 15.91 9.89 19 670698 586 109917996
Renal tubular disorder 15.90 9.89 13 670704 7416 109911166
Injection site urticaria 15.85 9.89 167 670550 17048 109901534
Sputum culture 15.83 9.89 14 670703 300 109918282
Allergic cough 15.83 9.89 25 670692 1010 109917572
Joint effusion 15.81 9.89 69 670648 20836 109897746
Swelling of eyelid 15.80 9.89 81 670636 6572 109912010
Cholecystectomy 15.76 9.89 116 670601 10693 109907889
Ocular hyperaemia 15.76 9.89 330 670387 38956 109879626
Otitis media 15.70 9.89 88 670629 7388 109911194
Blood immunoglobulin E abnormal 15.69 9.89 7 670710 40 109918542
Immune-mediated myositis 15.67 9.89 9 670708 6177 109912405
Rash pustular 15.66 9.89 34 670683 12795 109905787
Neuralgia 15.65 9.89 395 670322 48083 109870499
Foetal macrosomia 15.63 9.89 9 670708 94 109918488
Creatinine renal clearance increased 15.62 9.89 53 670664 3572 109915010
Drug level above therapeutic 15.61 9.89 29 670688 11559 109907023
Hypoglycaemic coma 15.59 9.89 7 670710 5526 109913056
Diaphragmatic disorder 15.58 9.89 35 670682 1851 109916731
Injection site vesicles 15.57 9.89 61 670656 4410 109914172
Steroid dependence 15.57 9.89 17 670700 8452 109910130
Gallbladder injury 15.56 9.89 28 670689 1260 109917322
Dizziness 15.52 9.89 4601 666116 693592 109224990
Vomiting 15.52 9.89 5116 665601 905559 109013023
Upper airway resistance syndrome 15.46 9.89 5 670712 9 109918573
Fibromuscular dysplasia 15.42 9.89 14 670703 311 109918271
Intentional dose omission 15.42 9.89 188 670529 19892 109898690
Pulmonary eosinophilia 15.37 9.89 21 670696 743 109917839
Incorrect dose administered by product 15.36 9.89 13 670704 262 109918320
Pancreatitis acute 15.32 9.89 265 670452 60009 109858573
Hypoglobulinaemia 15.27 9.89 12 670705 217 109918365
Drug tolerance decreased 15.22 9.89 101 670616 27439 109891143
Squamous cell carcinoma 15.17 9.89 59 670658 18404 109900178
Facial discomfort 15.17 9.89 15 670702 372 109918210
Supraventricular tachycardia 15.16 9.89 220 670497 24202 109894380
Macular oedema 15.15 9.89 12 670705 6954 109911628
Magnetic resonance imaging thoracic abnormal 15.12 9.89 5 670712 10 109918572
Product cleaning inadequate 15.12 9.89 5 670712 10 109918572
Immune-mediated enterocolitis 15.08 9.89 24 670693 10161 109908421
Dysuria 15.04 9.89 475 670242 59756 109858826
Mycobacterium test positive 15.03 9.89 19 670698 622 109917960
Iridocyclitis 14.99 9.89 7 670710 5401 109913181
Psychotic disorder 14.94 9.89 218 670499 50719 109867863
Essential hypertension 14.94 9.89 90 670627 7757 109910825
Cerebral haematoma 14.93 9.89 22 670695 9610 109908972
Postoperative renal failure 14.87 9.89 11 670706 181 109918401
Testicular swelling 14.86 9.89 32 670685 1644 109916938
Nasal mucosal discolouration 14.81 9.89 8 670709 73 109918509
Muscular weakness 14.79 9.89 1301 669416 247167 109671415
Urosepsis 14.78 9.89 117 670600 30558 109888024
Hepatitis acute 14.77 9.89 61 670656 18705 109899877
Post-traumatic stress disorder 14.76 9.89 79 670638 6517 109912065
Paradoxical drug reaction 14.66 9.89 23 670694 9794 109908788
Oxygen saturation 14.66 9.89 15 670702 388 109918194
Pulmonary artery dilatation 14.59 9.89 19 670698 641 109917941
Central nervous system lesion 14.59 9.89 47 670670 15506 109903076
Hydronephrosis 14.56 9.89 70 670647 20595 109897987
Tongue pruritus 14.54 9.89 22 670695 856 109917726
Wound complication 14.52 9.89 75 670642 6102 109912480
Peritonitis bacterial 14.51 9.89 26 670691 10507 109908075
Bladder prolapse 14.51 9.89 29 670688 1413 109917169
Oral mucosal blistering 14.47 9.89 90 670627 7844 109910738
Hemiplegia 14.46 9.89 80 670637 22702 109895880
Grip strength 14.43 9.89 100 670617 9041 109909541
JC virus infection 14.43 9.89 7 670710 5283 109913299
Foreign body aspiration 14.40 9.89 17 670700 518 109918064
Virologic failure 14.37 9.89 6 670711 4946 109913636
Mood swings 14.36 9.89 206 670511 22606 109895976
Retinal artery occlusion 14.32 9.89 4 670713 4245 109914337
Coronary artery disease 14.32 9.89 551 670166 71139 109847443
Gastric haemorrhage 14.31 9.89 49 670668 15866 109902716
Meningitis 14.30 9.89 31 670686 11671 109906911
Neuroglycopenia 14.27 9.89 25 670692 1101 109917481
Neck injury 14.26 9.89 47 670670 3121 109915461
Orthopnoea 14.24 9.89 115 670602 10906 109907676
Cytomegalovirus test positive 14.22 9.89 13 670704 7023 109911559
Hyperventilation 14.20 9.89 98 670619 8849 109909733
Pneumococcal infection 14.19 9.89 33 670684 1786 109916796
Breast cancer recurrent 14.17 9.89 3 670714 3843 109914739
Arteriosclerosis 14.16 9.89 220 670497 24547 109894035
Haemolysis 14.16 9.89 48 670669 15591 109902991
Neoplasm recurrence 14.15 9.89 7 670710 5225 109913357
Intestinal perforation 14.15 9.89 72 670645 20872 109897710
Monoparesis 14.07 9.89 5 670712 4548 109914034
Neurosensory hypoacusis 14.05 9.89 12 670705 245 109918337
Asbestosis 14.02 9.89 10 670707 155 109918427
Pneumococcal sepsis 13.95 9.89 37 670680 2175 109916407
Hepatic cirrhosis 13.94 9.89 308 670409 67318 109851264
Oropharyngeal candidiasis 13.93 9.89 35 670682 1991 109916591
Type I hypersensitivity 13.92 9.89 11 670706 6382 109912200
Social avoidant behaviour 13.91 9.89 67 670650 5302 109913280
Spondylitis 13.88 9.89 30 670687 11308 109907274
Body temperature abnormal 13.88 9.89 46 670671 3063 109915519
Muscle spasticity 13.86 9.89 300 670417 35615 109882967
Accessory spleen 13.85 9.89 11 670706 202 109918380
Paresis 13.85 9.89 6 670711 4838 109913744
Oral pruritus 13.83 9.89 48 670669 3272 109915310
Irritability 13.83 9.89 384 670333 47425 109871157
Klebsiella sepsis 13.83 9.89 4 670713 4149 109914433
Eating disorder 13.82 9.89 120 670597 30738 109887844
Nocardiosis 13.79 9.89 15 670702 7471 109911111
Biliary dyskinesia 13.78 9.89 39 670678 2382 109916200
Iron deficiency 13.76 9.89 172 670545 18304 109900278
Acute lymphocytic leukaemia 13.75 9.89 9 670708 5756 109912826
Right ventricular systolic pressure 13.72 9.89 5 670712 15 109918567
Sexual dysfunction 13.70 9.89 19 670698 8511 109910071
Decreased gait velocity 13.67 9.89 11 670706 206 109918376
Gastrointestinal perforation 13.67 9.89 15 670702 7441 109911141
Hernia pain 13.52 9.89 16 670701 489 109918093
Dehydration 13.51 9.89 1486 669231 278025 109640557
Retinal haemorrhage 13.50 9.89 23 670694 9478 109909104
Polyarthritis 13.50 9.89 64 670653 18899 109899683
Device use issue 13.48 9.89 52 670665 3732 109914850
Suicidal ideation 13.48 9.89 698 670019 93239 109825343
Inguinal hernia repair 13.47 9.89 14 670703 369 109918213
Viral upper respiratory tract infection 13.46 9.89 107 670610 10101 109908481
Product administration error 13.45 9.89 308 670409 36909 109881673
Stem cell transplant 13.45 9.89 5 670712 4422 109914160
Hospice care 13.43 9.89 125 670592 12348 109906234
Cystic fibrosis lung 13.39 9.89 10 670707 167 109918415
Drug level below therapeutic 13.39 9.89 32 670685 11641 109906941
Radioallergosorbent test positive 13.35 9.89 6 670711 35 109918547
Thunderclap headache 13.35 9.89 17 670700 561 109918021
Gastrointestinal haemorrhage 13.31 9.89 845 669872 164673 109753909
Necrosis 13.30 9.89 31 670686 11375 109907207
Tracheostomy malfunction 13.29 9.89 10 670707 169 109918413
Dependence on oxygen therapy 13.24 9.89 19 670698 704 109917878
Motor neurone disease 13.22 9.89 19 670698 705 109917877
Emergency care 13.18 9.89 28 670689 1425 109917157
Bradypnoea 13.17 9.89 20 670697 8629 109909953
Nasal ulcer 13.13 9.89 40 670677 2547 109916035
Expired product administered 13.12 9.89 91 670626 8229 109910353
Accidental death 13.11 9.89 7 670710 5002 109913580
Clubbing 13.09 9.89 20 670697 785 109917797
Neuropsychiatric symptoms 13.08 9.89 26 670691 1262 109917320
Foot deformity 13.02 9.89 211 670506 48269 109870313
Brain injury 13.01 9.89 132 670585 13344 109905238
Gingival hypertrophy 12.97 9.89 5 670712 4326 109914256
Pneumonitis 12.95 9.89 578 670139 75953 109842629
Varicella zoster gastritis 12.94 9.89 6 670711 38 109918544
Oxygen consumption decreased 12.94 9.89 16 670701 512 109918070
Blood urea increased 12.90 9.89 245 670472 54712 109863870
Breast cancer female 12.90 9.89 36 670681 12432 109906150
Prostate cancer 12.90 9.89 156 670561 37485 109881097
Flail chest 12.88 9.89 8 670709 97 109918485
Spinal pain 12.88 9.89 63 670654 18452 109900130
Platelet count increased 12.88 9.89 228 670489 26106 109892476
Product availability issue 12.86 9.89 87 670630 7803 109910779
Blood cholesterol decreased 12.86 9.89 41 670676 2675 109915907
Overweight 12.86 9.89 75 670642 6389 109912193
Abnormal clotting factor 12.85 9.89 10 670707 178 109918404
Oesophageal perforation 12.84 9.89 30 670687 1629 109916953
Mucosal discolouration 12.83 9.89 22 670695 952 109917630
Eye discharge 12.79 9.89 94 670623 8660 109909922
Thrombosis 12.79 9.89 793 669924 107869 109810713
Panic reaction 12.78 9.89 65 670652 5257 109913325
Acute febrile neutrophilic dermatosis 12.77 9.89 7 670710 4929 109913653
Aortic dissection 12.75 9.89 7 670710 4926 109913656
Accelerated idioventricular rhythm 12.73 9.89 12 670705 280 109918302
Foreign body in throat 12.70 9.89 23 670694 1040 109917542
Cortisol decreased 12.70 9.89 42 670675 2794 109915788
Pseudomembranous colitis 12.69 9.89 12 670705 6379 109912203
Vaccination site pain 12.68 9.89 16 670701 523 109918059
Injection site eczema 12.68 9.89 8 670709 100 109918482
Osteolysis 12.67 9.89 9 670708 5514 109913068
Poor quality sleep 12.65 9.89 240 670477 27837 109890745
Capillary leak syndrome 12.64 9.89 7 670710 4901 109913681
Flour sensitivity 12.63 9.89 5 670712 20 109918562
Oesophageal pain 12.59 9.89 63 670654 5062 109913520
Gastrointestinal necrosis 12.57 9.89 13 670704 6627 109911955
Pneumonia respiratory syncytial viral 12.57 9.89 41 670676 2708 109915874
Herpes simplex 12.56 9.89 51 670666 15713 109902869
Calcinosis 12.56 9.89 42 670675 2810 109915772
Ankle fracture 12.49 9.89 179 670538 19640 109898942
Infusion site pain 12.48 9.89 161 670556 17258 109901324
Pneumonectomy 12.47 9.89 8 670709 103 109918479
Red blood cell count increased 12.47 9.89 61 670656 4857 109913725
Functional residual capacity abnormal 12.44 9.89 4 670713 7 109918575
Non-cardiac chest pain 12.42 9.89 105 670612 10093 109908489
Eye operation 12.39 9.89 40 670677 2627 109915955
Staphylococcal sepsis 12.37 9.89 59 670658 17395 109901187
Gastrostomy tube removal 12.33 9.89 3 670714 0 109918582
Arteritis coronary 12.33 9.89 7 670710 71 109918511
SARS-CoV-2 test positive 12.33 9.89 157 670560 16778 109901804
Carcinoid tumour of the gastrointestinal tract 12.32 9.89 9 670708 145 109918437
Asthenia 12.32 9.89 3863 666854 685136 109233446
Generalised anxiety disorder 12.30 9.89 41 670676 2738 109915844
Hallucination 12.27 9.89 742 669975 100690 109817892
Pathological fracture 12.26 9.89 35 670682 11997 109906585
Dizziness exertional 12.24 9.89 19 670698 756 109917826
Hypernatraemia 12.22 9.89 61 670656 17772 109900810
Oculogyric crisis 12.20 9.89 4 670713 3828 109914754
Sinus bradycardia 12.19 9.89 117 670600 29366 109889216
Lymphocytosis 12.17 9.89 9 670708 5402 109913180
Urticaria pressure 12.17 9.89 7 670710 73 109918509
Respiratory arrest 12.17 9.89 265 670452 58034 109860548
Autoscopy 12.15 9.89 8 670709 108 109918474
Intestinal haemorrhage 12.15 9.89 16 670701 7325 109911257
Skin exfoliation 12.11 9.89 649 670068 87002 109831580
Brain herniation 12.10 9.89 22 670695 8841 109909741
Psychomotor skills impaired 12.08 9.89 15 670702 7043 109911539
Aggression 12.04 9.89 456 670261 58754 109859828
Breast cancer stage II 12.02 9.89 107 670610 27268 109891314
Hepatitis E 12.01 9.89 6 670711 4453 109914129
Prerenal failure 12.01 9.89 6 670711 4453 109914129
Hypersomnia 12.01 9.89 238 670479 27823 109890759
Percussion test abnormal 11.99 9.89 6 670711 46 109918536
Hyperphosphataemia 11.99 9.89 152 670565 16229 109902353
Chills 11.97 9.89 1326 669391 189254 109729328
Febrile infection 11.96 9.89 6 670711 4442 109914140
Atrioventricular block complete 11.95 9.89 72 670645 20010 109898572
Peripheral vascular disorder 11.92 9.89 91 670626 8485 109910097
Infusion site pruritus 11.91 9.89 61 670656 4947 109913635
Paraplegia 11.90 9.89 12 670705 6188 109912394
Aneurysm 11.89 9.89 56 670661 4390 109914192
Fistula 11.87 9.89 50 670667 15249 109903333
Sinus node dysfunction 11.87 9.89 23 670694 9024 109909558
Nasal dryness 11.87 9.89 67 670650 5639 109912943
Ileus 11.85 9.89 124 670593 30605 109887977
Renal cancer 11.80 9.89 40 670677 12994 109905588
Ventricular hyperkinesia 11.77 9.89 12 670705 309 109918273
Nightmare 11.77 9.89 314 670403 38549 109880033
Hepatic encephalopathy 11.74 9.89 112 670605 28144 109890438
Delusion 11.73 9.89 90 670627 23665 109894917
Sarcopenia 11.72 9.89 24 670693 1190 109917392
Allergy to plants 11.71 9.89 20 670697 863 109917719
Skin fissures 11.69 9.89 211 670506 24247 109894335
Personal relationship issue 11.64 9.89 10 670707 206 109918376
Initial insomnia 11.63 9.89 105 670612 10284 109908298
Musculoskeletal disorder 11.60 9.89 85 670632 22579 109896003
Trifascicular block 11.60 9.89 10 670707 207 109918375
Dyskinesia 11.57 9.89 231 670486 51215 109867367
Dermatitis exfoliative 11.57 9.89 33 670684 11314 109907268
Ankylosing spondylitis 11.52 9.89 52 670665 15560 109903022
Bronchitis haemophilus 11.50 9.89 4 670713 10 109918572
Dysmetropsia 11.49 9.89 8 670709 119 109918463
Haemorrhage subcutaneous 11.48 9.89 10 670707 5529 109913053
Chest injury 11.46 9.89 46 670671 3363 109915219
Methaemoglobinaemia 11.44 9.89 24 670693 9144 109909438
Coeliac disease 11.43 9.89 343 670374 42844 109875738
Hepatocellular carcinoma 11.40 9.89 27 670690 9853 109908729
Accidental exposure to product 11.36 9.89 390 670327 49618 109868964
Adrenal suppression 11.35 9.89 29 670688 1667 109916915
International normalised ratio increased 11.32 9.89 421 670296 86351 109832231
Vitreous haemorrhage 11.31 9.89 7 670710 4613 109913969
Tooth loss 11.30 9.89 86 670631 8010 109910572
Tongue exfoliation 11.30 9.89 9 670708 166 109918416
Megacolon 11.29 9.89 6 670711 4299 109914283
Prothrombin time shortened 11.27 9.89 4 670713 3642 109914940
Normal newborn 11.27 9.89 82 670635 21814 109896768
Restless legs syndrome 11.27 9.89 211 670506 24415 109894167
Bronchopulmonary dysplasia 11.25 9.89 11 670706 269 109918313
Decreased immune responsiveness 11.23 9.89 98 670619 9508 109909074
Perennial allergy 11.23 9.89 4 670713 11 109918571
Upper airway obstruction 11.22 9.89 30 670687 1772 109916810
Bronchoscopy 11.22 9.89 8 670709 124 109918458
Sensory loss 11.21 9.89 80 670637 21377 109897205
Dry throat 11.19 9.89 95 670622 9143 109909439
Dyskinesia oesophageal 11.18 9.89 6 670711 54 109918528
Myasthenia gravis 11.15 9.89 188 670529 21323 109897259
Bone cyst 11.06 9.89 4 670713 3599 109914983
Lipohypertrophy 11.06 9.89 21 670696 985 109917597
Paraneoplastic rash 11.06 9.89 7 670710 88 109918494
Renal artery stent placement 11.06 9.89 7 670710 88 109918494
Red cell distribution width abnormal 11.05 9.89 11 670706 275 109918307
Product administered at inappropriate site 11.01 9.89 63 670654 5330 109913252
Cystic fibrosis hepatic disease 11.00 9.89 6 670711 56 109918526
Chorea 10.99 9.89 3 670714 3232 109915350
Hepatic cancer 10.97 9.89 33 670684 11123 109907459
Lung transplant 10.95 9.89 62 670655 5224 109913358
Systemic candida 10.92 9.89 28 670689 9946 109908636
Prostatic specific antigen increased 10.92 9.89 39 670678 12472 109906110
Oedema peripheral 10.90 9.89 2205 668512 326455 109592127
Myelitis 10.87 9.89 3 670714 3210 109915372
Cleft palate 10.84 9.89 13 670704 403 109918179
Tobacco user 10.82 9.89 18 670699 760 109917822
Endocrine ophthalmopathy 10.81 9.89 25 670692 1348 109917234
Cardiac failure chronic 10.80 9.89 45 670672 13766 109904816
Tooth abscess 10.78 9.89 167 670550 18622 109899960
Liver abscess 10.75 9.89 19 670698 7720 109910862
Sinus headache 10.74 9.89 68 670649 5964 109912618
Immune-mediated hepatitis 10.73 9.89 15 670702 6696 109911886
Psychotic symptom 10.73 9.89 5 670712 3862 109914720
Cyanosis 10.71 9.89 246 670471 29495 109889087
Pyelonephritis acute 10.68 9.89 17 670700 7196 109911386
IgA nephropathy 10.67 9.89 3 670714 3170 109915412
Coronary artery stenosis 10.66 9.89 45 670672 13713 109904869
Splenomegaly 10.65 9.89 96 670621 24402 109894180
Anal fissure 10.62 9.89 28 670689 9853 109908729
Tooth disorder 10.61 9.89 121 670596 29388 109889194
Migraine 10.60 9.89 1193 669524 170459 109748123
Reaction to excipient 10.60 9.89 32 670685 2027 109916555
Lactose intolerance 10.60 9.89 39 670678 2737 109915845
Symptom recurrence 10.58 9.89 57 670660 4715 109913867
Injection related reaction 10.57 9.89 27 670690 1551 109917031
Vitamin D decreased 10.55 9.89 117 670600 12098 109906484
Muscle rigidity 10.52 9.89 94 670623 23937 109894645
Blebitis 10.51 9.89 4 670713 14 109918568
Ocular discomfort 10.47 9.89 88 670629 8445 109910137
Subcutaneous drug absorption impaired 10.47 9.89 19 670698 7640 109910942
Allergic sinusitis 10.44 9.89 29 670688 1752 109916830
Systemic infection 10.42 9.89 28 670689 9791 109908791
Vasomotor rhinitis 10.41 9.89 10 670707 239 109918343
Staphylococcal bacteraemia 10.37 9.89 59 670658 16629 109901953
Aptyalism 10.34 9.89 19 670698 869 109917713
Lip pruritus 10.33 9.89 24 670693 1298 109917284
Haemolytic uraemic syndrome 10.33 9.89 9 670708 4976 109913606
Infusion site extravasation 10.31 9.89 112 670605 11522 109907060
Immunisation reaction 10.30 9.89 18 670699 791 109917791
Thrombotic thrombocytopenic purpura 10.30 9.89 17 670700 7094 109911488
Respiratory tract infection viral 10.30 9.89 66 670651 5812 109912770
Menopausal symptoms 10.28 9.89 36 670681 2465 109916117
Steatorrhoea 10.27 9.89 21 670696 1040 109917542
Laryngeal erythema 10.27 9.89 3 670714 3 109918579
Testicular operation 10.27 9.89 3 670714 3 109918579
Postpartum anxiety 10.27 9.89 3 670714 3 109918579
Restlessness 10.27 9.89 261 670456 55998 109862584
Vascular purpura 10.27 9.89 5 670712 3766 109914816
Cutaneous vasculitis 10.26 9.89 41 670676 12688 109905894
Breath sounds 10.26 9.89 8 670709 143 109918439
Tendon calcification 10.25 9.89 9 670708 191 109918391
Lung infiltration 10.25 9.89 208 670509 24420 109894162
Dislocation of vertebra 10.24 9.89 195 670522 43526 109875056
Syringe issue 10.23 9.89 27 670690 9498 109909084
Product contamination physical 10.23 9.89 11 670706 302 109918280
Eyelid disorder 10.22 9.89 35 670682 2370 109916212
Left-to-right cardiac shunt 10.21 9.89 9 670708 192 109918390
Caesarean section 10.21 9.89 46 670671 13771 109904811
PO2 decreased 10.21 9.89 42 670675 3106 109915476
Gene mutation 10.20 9.89 4 670713 3425 109915157
Type IIa hyperlipidaemia 10.19 9.89 14 670703 498 109918084
Intraventricular haemorrhage 10.18 9.89 11 670706 5496 109913086
Anti-cyclic citrullinated peptide antibody 10.16 9.89 75 670642 19889 109898693
Renal injury 10.16 9.89 69 670648 18644 109899938
Pancreatitis necrotising 10.16 9.89 11 670706 5490 109913092
Adjusted calcium decreased 10.15 9.89 10 670707 247 109918335
Quarantine 10.14 9.89 5 670712 37 109918545
Bacterial sepsis 10.14 9.89 31 670686 10395 109908187
Respiratory tract infection bacterial 10.13 9.89 35 670682 2381 109916201
Peptic ulcer 10.12 9.89 80 670637 7539 109911043
Infantile haemangioma 10.10 9.89 4 670713 16 109918566
Intervertebral disc degeneration 10.10 9.89 160 670557 17925 109900657
Gaze palsy 10.10 9.89 4 670713 3403 109915179
Mycobacterium chelonae infection 10.09 9.89 3 670714 3057 109915525
Pneumatosis intestinalis 10.09 9.89 23 670694 8506 109910076
Bipolar disorder 10.07 9.89 91 670626 8916 109909666
Lipase increased 10.06 9.89 69 670648 18603 109899979
Peripheral circulatory failure 10.06 9.89 29 670688 1790 109916792
Electrocardiogram QT prolonged 10.06 9.89 549 670168 108411 109810171
Tricuspid valve incompetence 10.06 9.89 202 670515 23671 109894911
Bacterial tracheitis 10.01 9.89 7 670710 105 109918477
Nasal polypectomy 10.01 9.89 6 670711 68 109918514
Purpura 9.99 9.89 97 670620 24291 109894291
Oesophagogastroduodenoscopy 9.98 9.89 10 670707 252 109918330
Hallucination, auditory 9.98 9.89 107 670610 26290 109892292
Grunting 9.96 9.89 15 670702 581 109918001
Red cell distribution width increased 9.93 9.89 156 670561 17446 109901136
Infectious pleural effusion 9.93 9.89 9 670708 4882 109913700
School refusal 9.92 9.89 5 670712 39 109918543
Neuromyotonia 9.90 9.89 7 670710 107 109918475

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03AK04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK15 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03CC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
FDA MoA N0000009922 Adrenergic beta2-Agonists
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35522 ฮฒ-adrenergic agonist
CHEBI has role CHEBI:35523 bronchodilator agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:90753 antidote to organophosphate poisoning
CHEBI has role CHEBI:233423 antifibrotic agent
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D001993 Bronchodilator Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D015149 Tocolytic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
FDA EPC N0000175779 beta2-Adrenergic Agonist

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R03AK Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics 13 drugs
beclometasone dipropionatebudesonidecromoglicic acidepinephrinefluticasone furoatefluticasone propionateformoterolindacaterolisoprenalinemometasone furoatereproterolsalmeterol show all 13 →
R03AL Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids 14 drugs
aclidinium bromidebeclometasone dipropionatebudesonidefenoterolfluticasone furoateformoterolglycopyrronium bromideindacaterolipratropiummometasone furoateolodateroltiotropium bromide show all 14 →
R03CC Selective beta-2-adrenoreceptor agonists 14 drugs
ambroxolbambuterolcarbuterolclenbuterolfenoterolformoterolhexoprenalineisoetarinepirbuterolprocaterolreproterolterbutaline show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchospasm indication 4386001
Acute exacerbation of asthma indication 708038006
Bronchospasm Prevention indication
Exercise-Induced Bronchospasm Prevention indication
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Ketoacidosis contraindication 56051008
Metabolic acidosis contraindication 59455009
Diabetes mellitus contraindication 73211009 DOID:9351
Paradoxical bronchospasm contraindication 102578005
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Myocardial ischemia contraindication 414795007 DOID:3393
Congenital long QT syndrome contraindication 442917000




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Horses Immediate relief of bronchospasm and bronchoconstriction associated with reversible airway obstruction Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Torpex Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.07 acidic
pKa2 9.46 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 0.09MG BASE/INH;0.08MG/INH AIRSUPRA ASTRAZENECA N214070 Jan. 10, 2023 RX AEROSOL, METERED INHALATION 9415009 May 28, 2030 AS-NEEDED TREATMENT OR PREVENTION OF BRONCHOCONSTRICTION AND REDUCTION OF THE RISK OF EXACERBATIONS IN PATIENTS WITH ASTHMA 18 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 0.09MG BASE/INH;0.08MG/INH AIRSUPRA ASTRAZENECA N214070 Jan. 10, 2023 RX AEROSOL, METERED INHALATION Jan. 10, 2026 NEW PRODUCT
EQ 0.09MG BASE/INH ALBUTEROL SULFATE CIPLA A219409 April 22, 2026 RX AEROSOL, METERED INHALATION Dec. 19, 2026 COMPETITIVE GENERIC THERAPY
EQ 0.09MG BASE/INH;0.08MG/INH AIRSUPRA ASTRAZENECA N214070 Jan. 10, 2023 RX AEROSOL, METERED INHALATION Sept. 15, 2028 LABELING REVISIONS TO REFLECT THE RESULTS OF BATURA STUDY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST Ki 5.95 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.61 PDSP
Beta-2 adrenergic receptor GPCR Kd 5.94 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.28 CHEMBL

External reference:

IDSource
4018796 VUID
N0000147099 NUI
D02147 KEGG_DRUG
51022-70-9 SECONDARY_CAS_RN
142153 RXNORM
C0001927 UMLSCUI
CHEBI:2549 CHEBI
68H PDB_CHEM_ID
CHEMBL714 ChEMBL_ID
DB01001 DRUGBANK_ID
CHEMBL1441059 ChEMBL_ID
2083 PUBCHEM_CID
558 IUPHAR_LIGAND_ID
3007 MMSL
30960 MMSL
4143 MMSL
4144 MMSL
46702 MMSL
d00749 MMSL
D000420 MESH_DESCRIPTOR_UI
2585 INN_ID
4018796 VANDF
4018797 VANDF
QF8SVZ843E UNII
001814 NDDF
001815 NDDF
372897005 SNOMEDCT_US
48474002 SNOMEDCT_US
91143003 SNOMEDCT_US
QF8SVZ843E INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0742 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) ANDA 14 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA authorized generic 26 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
AIRSUPRA HUMAN PRESCRIPTION DRUG LABEL 2 0310-9080 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 30 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-7057 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-7058 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-8270 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 24 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0378-9671 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0487-0201 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 29 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-0301 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 27 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9501 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 24 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9901 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 24 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9904 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 27 sections
Combivent Respimat HUMAN PRESCRIPTION DRUG LABEL 2 0597-0024 SPRAY, METERED 100 ug RESPIRATORY (INHALATION) NDA 27 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7296 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 16590-339 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 27 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 17270-0740 INHALANT 90 ug RESPIRATORY (INHALATION) ANDA 27 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 17856-0740 SYRUP 2 mg ORAL ANDA 19 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 21695-198 AEROSOL, METERED 90 ug ORAL ANDA 24 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-245 SOLUTION 5 mg RESPIRATORY (INHALATION) ANDA 18 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-332 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-350 SYRUP 2 mg ORAL ANDA 19 sections
VENTOLINHFA HFA HUMAN PRESCRIPTION DRUG LABEL 1 21695-423 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 28 sections
PROAIRHFA HUMAN PRESCRIPTION DRUG LABEL 1 21695-851 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 27 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 33261-789 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 42254-004 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
albuterol sulfate HUMAN PRESCRIPTION DRUG LABEL 1 45802-088 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) ANDA 27 sections
Albuterol Sulfate Human Prescription Drug Label 1 47335-703 SOLUTION 0.83 mg RESPIRATORY (INHALATION) ANDA 20 sections
Ipratropium Bromide and Albuterol Sulfate Human Prescription Drug Label 2 47335-756 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 22 sections