salbutamol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 105 18559-94-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salbutamol
  • albuterol
  • sabumol
  • dl-Albuterol
  • dl-Salbutamol
  • albuterol sulfate
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
  • Molecular weight: 239.32
  • Formula: C13H21NO3
  • CLOGP: 0.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -2.05
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
10 mg Inhal.solution
12 mg O
12 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.23 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.92 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 68 mg/mL Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 0.02 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
BA (Bioavailability) 0.44 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
May 1, 1981 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 5787.47 10.06 5559 414776 122002 62946685
Wheezing 3285.89 10.06 3591 416744 92004 62976683
Dyspnoea 2503.34 10.06 9792 410543 651521 62417166
Obstructive airways disorder 1950.71 10.06 1382 418953 19317 63049370
Cough 1558.08 10.06 4862 415473 287881 62780806
Sleep disorder due to a general medical condition 1464.26 10.06 946 419389 11242 63057445
Full blood count abnormal 1377.37 10.06 1352 418983 30365 63038322
Poor quality device used 1333.81 10.06 506 419829 1565 63067122
Product quality issue 1331.95 10.06 1405 418930 34460 63034227
Productive cough 1120.34 10.06 1712 418623 61496 63007191
Pemphigus 1073.29 10.06 31 420304 183695 62884992
Chronic obstructive pulmonary disease 994.78 10.06 1614 418721 61072 63007615
Forced expiratory volume decreased 912.96 10.06 507 419828 4461 63064226
Hand deformity 873.10 10.06 44 420291 159413 62909274
Synovitis 870.09 10.06 107 420228 186811 62881876
Chest discomfort 836.86 10.06 2083 418252 107886 62960801
Sputum discoloured 830.04 10.06 760 419575 15587 63053100
Glossodynia 826.25 10.06 105 420230 178771 62889916
Systemic lupus erythematosus 823.68 10.06 187 420148 208731 62859956
Completed suicide 714.41 10.06 69 420266 145604 62923083
Infective pulmonary exacerbation of cystic fibrosis 713.32 10.06 537 419798 8280 63060407
Arthropathy 704.02 10.06 337 419998 234455 62834232
Treatment failure 672.14 10.06 239 420096 198804 62869883
Alopecia 654.36 10.06 763 419572 336773 62731914
Drug intolerance 634.23 10.06 665 419670 307996 62760691
Anti-cyclic citrullinated peptide antibody positive 620.75 10.06 37 420298 116175 62952512
Pneumonia 616.49 10.06 5141 415194 451626 62617061
Contraindicated product administered 597.08 10.06 350 419985 217298 62851389
Off label use 577.86 10.06 2404 417931 672058 62396629
Bronchitis 574.39 10.06 1977 418358 122958 62945729
Drug ineffective 565.88 10.06 4332 416003 1040433 62028254
Pericarditis 542.56 10.06 106 420229 131473 62937214
Wound 527.73 10.06 210 420125 163053 62905634
Device delivery system issue 521.00 10.06 195 420140 574 63068113
Therapeutic product effect incomplete 470.62 10.06 1855 418480 123201 62945486
Therapeutic product effect decreased 433.94 10.06 384 419951 192803 62875884
Abdominal discomfort 426.24 10.06 932 419403 319953 62748734
Helicobacter infection 422.15 10.06 57 420278 92728 62975959
Infusion related reaction 421.81 10.06 607 419728 244914 62823773
Product dose omission issue 396.02 10.06 2782 417553 231531 62837156
Hepatic enzyme increased 389.86 10.06 459 419876 201869 62866818
Duodenal ulcer perforation 386.41 10.06 58 420277 87151 62981536
Respiratory disorder 366.64 10.06 804 419531 38278 63030409
Nasal polyps 352.76 10.06 304 420031 5735 63062952
Middle insomnia 338.06 10.06 418 419917 12225 63056462
Nasal congestion 338.05 10.06 1080 419255 64580 63004107
Dyspnoea exertional 325.26 10.06 1008 419327 59294 63009393
Loss of personal independence in daily activities 314.74 10.06 1378 418957 95912 62972775
Eosinophil count increased 312.84 10.06 374 419961 10554 63058133
Maternal exposure during pregnancy 311.50 10.06 616 419719 219446 62849241
Sleep apnoea syndrome 295.88 10.06 619 419716 28514 63040173
Swelling 292.40 10.06 895 419440 274483 62794204
Rheumatoid factor positive 292.21 10.06 97 420238 84309 62984378
Neutropenia 287.46 10.06 446 419889 174559 62894128
Discomfort 285.12 10.06 416 419919 166958 62901729
Blood immunoglobulin E increased 279.77 10.06 220 420115 3629 63065058
Gastrooesophageal reflux disease 277.58 10.06 1312 419023 94327 62974360
Rheumatoid arthritis 277.30 10.06 814 419521 253005 62815682
Ear pain 266.90 10.06 677 419658 35441 63033246
Rhinitis allergic 262.35 10.06 355 419980 11372 63057315
Toxicity to various agents 260.71 10.06 806 419529 246444 62822243
Upper respiratory tract infection 256.94 10.06 1151 419184 80896 62987791
Pulmonary function test decreased 251.72 10.06 209 420126 3738 63064949
Joint swelling 251.70 10.06 1214 419121 326452 62742235
Musculoskeletal stiffness 249.99 10.06 530 419805 184088 62884599
Bronchiectasis 236.24 10.06 401 419934 15741 63052946
No adverse event 233.41 10.06 703 419632 40702 63027985
Liver injury 230.72 10.06 58 420277 60462 63008225
Drug abuse 221.83 10.06 101 420234 72417 62996270
Bronchospasm 221.49 10.06 405 419930 16875 63051812
Sinusitis 217.89 10.06 2377 417958 224276 62844411
Impaired quality of life 217.24 10.06 354 419981 13429 63055258
Impaired healing 215.79 10.06 216 420119 102326 62966361
Breath sounds abnormal 215.42 10.06 312 420023 10661 63058026
Dysphonia 214.66 10.06 749 419586 46865 63021822
Upper-airway cough syndrome 213.09 10.06 317 420018 11101 63057586
Febrile neutropenia 210.02 10.06 286 420049 118163 62950524
Rales 209.54 10.06 333 420002 12364 63056323
Rheumatic fever 207.12 10.06 22 420313 43089 63025598
Influenza 197.66 10.06 1315 419020 107407 62961280
Thrombocytopenia 196.29 10.06 444 419891 150713 62917974
Body temperature increased 196.17 10.06 617 419718 36575 63032112
Muscle injury 195.26 10.06 94 420241 65251 63003436
Respiratory tract infection 195.25 10.06 662 419673 40821 63027866
Intentional overdose 192.37 10.06 127 420208 74025 62994662
Lower respiratory tract infection 192.00 10.06 1516 418819 130791 62937896
Oropharyngeal pain 190.98 10.06 1174 419161 93313 62975374
Cystic fibrosis 190.65 10.06 165 420170 3131 63065556
Illness 186.18 10.06 730 419605 48329 63020358
Folliculitis 184.36 10.06 119 420216 70198 62998489
Heart rate increased 183.03 10.06 1159 419176 93079 62975608
Dermatitis atopic 182.95 10.06 271 420064 9453 63059234
General physical health deterioration 182.15 10.06 701 419634 200701 62867986
Malignant neoplasm progression 180.92 10.06 166 420169 81955 62986732
Pancytopenia 178.01 10.06 228 420107 96705 62971982
Sedation complication 177.21 10.06 324 420011 13498 63055189
Swollen joint count increased 176.84 10.06 17 420318 36037 63032650
Reversible airways obstruction 173.48 10.06 123 420212 1719 63066968
Stomatitis 173.27 10.06 416 419919 138309 62930378
Secretion discharge 172.61 10.06 299 420036 11932 63056755
Drug interaction 170.55 10.06 858 419477 228273 62840414
Food allergy 169.19 10.06 285 420050 11116 63057571
Arthralgia 165.56 10.06 2715 417620 566995 62501692
Urticaria 164.40 10.06 1750 418585 164052 62904635
Bronchial secretion retention 160.76 10.06 139 420196 2634 63066053
Polycystic ovaries 158.54 10.06 171 420164 4300 63064387
Sinus disorder 157.80 10.06 437 419898 24116 63044571
Sleep disorder due to general medical condition, insomnia type 156.19 10.06 75 420260 52142 63016545
Anaemia 155.74 10.06 1220 419115 292210 62776477
Blood test abnormal 155.10 10.06 329 420006 15300 63053387
Anxiety 154.67 10.06 2156 418179 215385 62853302
Seasonal allergy 153.00 10.06 391 419944 20559 63048128
Bronchopulmonary aspergillosis allergic 151.19 10.06 123 420212 2135 63066552
Asthmatic crisis 150.15 10.06 112 420223 1701 63066986
Creatinine renal clearance decreased 150.09 10.06 333 420002 15975 63052712
Emphysema 148.66 10.06 263 420072 10675 63058012
Intentional product use issue 144.01 10.06 404 419931 127488 62941199
Respiratory tract congestion 143.09 10.06 345 419990 17487 63051200
Eosinophilic bronchitis 140.78 10.06 71 420264 502 63068185
Psoriatic arthropathy 140.14 10.06 244 420091 91276 62977411
Leukopenia 139.64 10.06 184 420151 77106 62991581
Forced vital capacity decreased 137.62 10.06 87 420248 992 63067695
Peak expiratory flow rate decreased 137.38 10.06 72 420263 557 63068130
Irritable bowel syndrome 137.16 10.06 208 420127 82204 62986483
Sensitivity to weather change 136.59 10.06 202 420133 7035 63061652
Eosinophilic granulomatosis with polyangiitis 135.50 10.06 114 420221 2078 63066609
White blood cell count decreased 134.36 10.06 471 419864 138633 62930054
Hip arthroplasty 134.22 10.06 74 420261 47572 63021115
Device malfunction 132.20 10.06 335 420000 17522 63051165
Pulmonary function test abnormal 131.71 10.06 104 420231 1726 63066961
C-reactive protein increased 128.84 10.06 271 420064 94436 62974251
Sensitisation 126.24 10.06 133 420202 3253 63065434
Oxygen saturation decreased 126.24 10.06 1011 419324 87574 62981113
Lung hyperinflation 125.50 10.06 88 420247 1207 63067480
Haemoptysis 125.26 10.06 447 419888 28279 63040408
Product use issue 124.46 10.06 901 419434 219619 62849068
Platelet count decreased 124.05 10.06 376 419959 115746 62952941
Chest pain 124.01 10.06 2064 418271 213895 62854792
Rhinorrhoea 123.89 10.06 801 419534 64776 63003911
Respiration abnormal 122.40 10.06 180 420155 6237 63062450
Blister 121.09 10.06 446 419889 129368 62939319
Orthostatic hypotension 120.53 10.06 517 419818 35643 63033044
Headache 118.23 10.06 5221 415114 628020 62440667
Knee arthroplasty 117.70 10.06 111 420224 54095 63014592
Temperature regulation disorder 112.64 10.06 169 420166 5963 63062724
Pulmonary mass 112.00 10.06 367 419968 22229 63046458
Myelosuppression 111.57 10.06 13 420322 23690 63044997
Eosinophil count abnormal 110.75 10.06 61 420274 527 63068160
Sputum increased 108.88 10.06 106 420229 2353 63066334
Throat clearing 108.47 10.06 105 420230 2314 63066373
Lip swelling 107.31 10.06 449 419886 30614 63038073
Blood calcium decreased 107.23 10.06 402 419933 26049 63042638
Vital capacity decreased 107.09 10.06 90 420245 1638 63067049
Sputum purulent 105.66 10.06 74 420261 1013 63067674
Product container issue 104.19 10.06 90 420245 1703 63066984
Hepatic function abnormal 104.16 10.06 58 420277 37084 63031603
Muscle spasticity 102.71 10.06 348 419987 21446 63047241
Eczema 102.53 10.06 455 419880 31836 63036851
Respiratory symptom 101.52 10.06 118 420217 3229 63065458
Bronchial wall thickening 101.09 10.06 82 420253 1417 63067270
Acute respiratory failure 100.64 10.06 474 419861 34011 63034676
Blood cholesterol increased 99.34 10.06 306 420029 93726 62974961
Allergy to animal 98.81 10.06 75 420260 1171 63067516
Bronchial obstruction 98.61 10.06 81 420254 1426 63067261
Eosinophilia 98.27 10.06 353 419982 22403 63046284
Sopor 97.55 10.06 15 420320 22149 63046538
Respiratory distress 97.14 10.06 464 419871 33487 63035200
Therapy non-responder 96.01 10.06 226 420109 75675 62993012
Respiratory rate increased 95.83 10.06 251 420084 13397 63055290
Hepatocellular injury 95.56 10.06 31 420304 27350 63041337
Hypoventilation 94.52 10.06 136 420199 4618 63064069
Ejection fraction 94.17 10.06 97 420238 2309 63066378
Disease progression 93.94 10.06 455 419880 122303 62946384
Status asthmaticus 93.65 10.06 64 420271 840 63067847
Dust allergy 92.90 10.06 58 420277 646 63068041
Restrictive pulmonary disease 92.16 10.06 84 420251 1711 63066976
Alanine aminotransferase increased 91.93 10.06 364 419971 103406 62965281
Hospitalisation 91.85 10.06 914 419421 84167 62984520
Drug-induced liver injury 91.34 10.06 79 420256 40143 63028544
Circumstance or information capable of leading to medication error 90.92 10.06 120 420215 3750 63064937
Renal impairment 90.19 10.06 292 420043 88063 62980624
Drug tolerance decreased 89.06 10.06 7 420328 17466 63051221
Malaise 88.44 10.06 3478 416857 412476 62656211
Product delivery mechanism issue 88.21 10.06 45 420290 327 63068360
Coma 86.84 10.06 185 420150 64179 63004508
Sneezing 85.94 10.06 291 420044 17927 63050760
Swollen tongue 85.76 10.06 456 419879 34344 63034343
Bronchospasm paradoxical 85.66 10.06 30 420305 68 63068619
Red blood cell sedimentation rate increased 85.43 10.06 99 420236 43883 63024804
Burning sensation 84.74 10.06 634 419701 53773 63014914
Back pain 84.34 10.06 2318 418017 261827 62806860
Suicide attempt 81.43 10.06 176 420159 60742 63007945
Hepatotoxicity 81.41 10.06 75 420260 36966 63031721
Humidity intolerance 80.67 10.06 42 420293 320 63068367
Cardio-respiratory arrest 80.34 10.06 173 420162 59786 63008901
Anaphylactic reaction 80.24 10.06 728 419607 65372 63003315
Viral infection 78.99 10.06 454 419881 35209 63033478
Product complaint 78.40 10.06 224 420111 12585 63056102
Eye pruritus 78.39 10.06 287 420048 18384 63050303
Total lung capacity decreased 78.29 10.06 84 420251 2099 63066588
Sinus pain 77.44 10.06 104 420231 3306 63065381
Nasal obstruction 77.36 10.06 75 420260 1656 63067031
Throat tightness 76.25 10.06 347 419988 24540 63044147
Bone marrow failure 76.17 10.06 50 420285 29240 63039447
Total lung capacity increased 76.09 10.06 85 420250 2225 63066462
Product cleaning inadequate 75.28 10.06 20 420315 6 63068681
Aspartate aminotransferase increased 74.77 10.06 325 420010 89952 62978735
Rhinitis 74.72 10.06 204 420131 11162 63057525
Wrong technique in device usage process 74.59 10.06 105 420230 3493 63065194
Sedation 73.87 10.06 475 419860 38334 63030353
Toxic epidermal necrolysis 73.33 10.06 38 420297 25296 63043391
Coeliac disease 72.78 10.06 218 420117 12579 63056108
Rhonchi 71.83 10.06 87 420248 2489 63066198
C-reactive protein abnormal 71.36 10.06 122 420213 45974 63022713
Pharyngeal swelling 70.84 10.06 141 420194 6263 63062424
Metastases to liver 70.61 10.06 34 420301 23605 63045082
Confusional state 70.53 10.06 1120 419215 235260 62833427
Balance disorder 70.49 10.06 862 419473 83560 62985127
Mucosal inflammation 70.12 10.06 127 420208 46801 63021886
Multiple allergies 70.05 10.06 226 420109 13576 63055111
Condition aggravated 69.70 10.06 2079 418256 400138 62668549
Hypoxia 69.28 10.06 652 419683 59140 63009547
Acute kidney injury 68.63 10.06 1279 419056 262136 62806551
Drug reaction with eosinophilia and systemic symptoms 68.08 10.06 74 420261 33762 63034925
Rash 67.68 10.06 3030 417305 557841 62510846
Choking 67.65 10.06 180 420155 9699 63058988
Perfume sensitivity 67.27 10.06 50 420285 755 63067932
Inflammation 65.83 10.06 300 420035 81973 62986714
Paranasal sinus discomfort 65.74 10.06 110 420225 4266 63064421
Palpitations 65.45 10.06 1080 419255 111690 62956997
Decreased appetite 64.46 10.06 1222 419113 249830 62818857
Mite allergy 64.31 10.06 45 420290 615 63068072
Emotional distress 64.19 10.06 402 419933 32147 63036540
Multiple organ dysfunction syndrome 64.05 10.06 179 420156 56573 63012114
Bacterial disease carrier 63.91 10.06 60 420275 1271 63067416
Posterior reversible encephalopathy syndrome 61.66 10.06 19 420316 17326 63051361
Agranulocytosis 61.27 10.06 46 420289 25088 63043599
Animal scratch 60.69 10.06 60 420275 1358 63067329
Rheumatoid nodule 60.61 10.06 19 420316 17136 63051551
Neoplasm progression 60.54 10.06 92 420243 36336 63032351
COVID-19 60.49 10.06 1069 419266 112034 62956653
Cognitive disorder 60.41 10.06 600 419735 55215 63013472
Lung diffusion test abnormal 60.28 10.06 34 420301 309 63068378
Fluid retention 60.02 10.06 632 419703 59054 63009633
Cytomegalovirus infection 59.79 10.06 32 420303 20920 63047767
Urinary tract discomfort 59.69 10.06 43 420292 617 63068070
Gastrointestinal disorder 59.12 10.06 569 419766 130670 62938017
Drug resistance 58.49 10.06 40 420295 22893 63045794
Conjunctivitis allergic 58.25 10.06 49 420286 893 63067794
Asthma-chronic obstructive pulmonary disease overlap syndrome 58.11 10.06 70 420265 1991 63066696
Femur fracture 58.02 10.06 118 420217 41638 63027049
Smoke sensitivity 58.01 10.06 37 420298 429 63068258
Depression 57.86 10.06 1707 418628 194785 62873902
Chest X-ray abnormal 57.51 10.06 106 420229 4443 63064244
Cholestasis 57.43 10.06 66 420269 29368 63039319
Vocal cord dysfunction 56.67 10.06 39 420296 518 63068169
Incorrect dose administered 56.60 10.06 627 419708 59341 63009346
Prescribed underdose 56.40 10.06 68 420267 29621 63039066
Nasal turbinate hypertrophy 56.29 10.06 44 420291 719 63067968
Alveolar osteitis 55.99 10.06 47 420288 854 63067833
Death 55.79 10.06 1973 418362 372408 62696279
Poisoning deliberate 55.78 10.06 5 420330 11213 63057474
Aphonia 54.95 10.06 169 420166 9894 63058793
Night sweats 54.91 10.06 529 419806 48285 63020402
Nasal discharge discolouration 54.25 10.06 71 420264 2200 63066487
Fatigue 54.25 10.06 5104 415231 882924 62185763
Exposure during pregnancy 54.06 10.06 715 419620 154832 62913855
Joint range of motion decreased 53.79 10.06 82 420253 32346 63036341
Bronchial hyperreactivity 52.92 10.06 61 420274 1654 63067033
Hiatus hernia 52.55 10.06 282 420053 21312 63047375
Bronchial disorder 52.29 10.06 53 420282 1237 63067450
Lung opacity 52.15 10.06 83 420252 3085 63065602
Serotonin syndrome 52.08 10.06 68 420267 28614 63040073
Neurotoxicity 51.42 10.06 24 420311 16966 63051721
Neutrophil count decreased 51.13 10.06 196 420139 56210 63012477
Polyp 51.07 10.06 125 420210 6396 63062291
Lung diffusion test decreased 50.95 10.06 40 420295 658 63068029
Cardiac disorder 50.58 10.06 537 419798 50279 63018408
Lung neoplasm malignant 50.26 10.06 260 420075 19373 63049314
Overdose 50.12 10.06 503 419832 114575 62954112
Panniculitis 49.44 10.06 8 420327 11377 63057310
Musculoskeletal pain 49.15 10.06 383 419952 91894 62976793
Septic shock 48.07 10.06 252 420083 66377 63002310
Prolonged expiration 48.07 10.06 47 420288 1049 63067638
Infective exacerbation of chronic obstructive airways disease 47.98 10.06 50 420285 1207 63067480
Chronic sinusitis 47.81 10.06 190 420145 12653 63056034
Palmar-plantar erythrodysaesthesia syndrome 47.80 10.06 49 420286 22966 63045721
Sputum culture positive 47.56 10.06 65 420270 2102 63066585
Cholecystitis chronic 47.56 10.06 164 420171 10197 63058490
Inhalation therapy 47.35 10.06 16 420319 31 63068656
Insomnia 47.30 10.06 1807 418528 213445 62855242
Stress cardiomyopathy 47.29 10.06 154 420181 9296 63059391
Cerebral infarction 47.25 10.06 53 420282 23840 63044847
Sinus operation 47.11 10.06 71 420264 2515 63066172
Respiratory tract inflammation 47.11 10.06 36 420299 568 63068119
Drug dependence 46.80 10.06 300 420035 24183 63044504
Drug hypersensitivity 45.65 10.06 1640 418695 309047 62759640
Altered state of consciousness 45.62 10.06 60 420275 25170 63043517
Hypothyroidism 45.51 10.06 457 419878 42175 63026512
Shock 45.36 10.06 53 420282 23410 63045277
Increased bronchial secretion 44.99 10.06 57 420278 1709 63066978
Hepatic cytolysis 44.75 10.06 23 420312 15384 63053303
Blood parathyroid hormone decreased 44.55 10.06 6 420329 9785 63058902
Haematotoxicity 44.48 10.06 5 420330 9371 63059316
Drug eruption 44.36 10.06 76 420259 28618 63040069
Blood pressure increased 44.24 10.06 1395 418940 160667 62908020
Nasopharyngitis 44.06 10.06 2082 418253 252175 62816512
Blood pressure systolic increased 44.01 10.06 494 419841 46903 63021784
Tunnel vision 43.98 10.06 47 420288 1169 63067518
Multiple drug therapy 43.65 10.06 83 420252 3563 63065124
Nasal mucosal disorder 43.44 10.06 31 420304 438 63068249
Swelling face 43.37 10.06 625 419710 62850 63005837
Metastases to bone 43.37 10.06 45 420290 20974 63047713
Lung disorder 43.32 10.06 615 419720 61646 63007041
Exposure to allergen 43.07 10.06 27 420308 303 63068384
Foot deformity 42.85 10.06 74 420261 27779 63040908
Throat irritation 42.84 10.06 409 419926 37238 63031449
Constipation 42.68 10.06 1859 418476 223084 62845603
Lower respiratory tract congestion 42.63 10.06 72 420263 2814 63065873
Adverse event 42.56 10.06 267 420068 67292 63001395
Nausea 42.54 10.06 4982 415353 849489 62219198
Migraine 42.21 10.06 938 419397 102408 62966279
Increased upper airway secretion 42.01 10.06 82 420253 3590 63065097
Interstitial lung disease 41.99 10.06 239 420096 61669 63007018
Neuropathy peripheral 41.90 10.06 516 419819 113151 62955536
Osteonecrosis of jaw 41.73 10.06 108 420227 35015 63033672
Somnolence 41.55 10.06 884 419451 177801 62890886
Pulmonary embolism 41.52 10.06 1039 419296 115645 62953042
Cardiotoxicity 41.32 10.06 4 420331 8434 63060253
Hyper IgE syndrome 41.11 10.06 31 420304 479 63068208
Cerebral haemorrhage 40.88 10.06 89 420246 30640 63038047
Infusion site erythema 40.48 10.06 169 420166 11510 63057177
Hereditary angioedema 40.37 10.06 126 420209 7436 63061251
Sinusitis fungal 40.30 10.06 55 420280 1776 63066911
Limb injury 40.29 10.06 298 420037 25179 63043508
Cystic fibrosis respiratory infection suppression 40.23 10.06 25 420310 276 63068411
Disseminated intravascular coagulation 40.20 10.06 40 420295 19011 63049676
Spirometry abnormal 39.97 10.06 23 420312 218 63068469
Rash erythematous 39.89 10.06 444 419891 42066 63026621
Epilepsy 39.76 10.06 74 420261 26991 63041696
Frustration tolerance decreased 39.70 10.06 119 420216 6869 63061818
Tubulointerstitial nephritis 39.52 10.06 44 420291 19859 63048828
Forced expiratory flow decreased 39.51 10.06 17 420318 79 63068608
Breast cancer stage III 39.49 10.06 10 420325 10376 63058311
Product taste abnormal 39.45 10.06 58 420277 2009 63066678
Bronchial neoplasm 39.44 10.06 30 420305 470 63068217
Pruritus 38.91 10.06 2836 417499 358617 62710070
Blood lactate dehydrogenase increased 38.78 10.06 58 420277 23058 63045629
Pneumocystis jirovecii pneumonia 38.67 10.06 33 420302 16881 63051806
Infusion site swelling 38.37 10.06 147 420188 9623 63059064
Ejection fraction abnormal 38.36 10.06 53 420282 1732 63066955
Macular degeneration 38.20 10.06 64 420271 24312 63044375
Transplant rejection 37.98 10.06 12 420323 10768 63057919
Forced expiratory volume abnormal 37.94 10.06 16 420319 70 63068617
Foreign body in reproductive tract 37.88 10.06 35 420300 726 63067961
Infection 37.55 10.06 1193 419142 227980 62840707
Poisoning 37.54 10.06 22 420313 13678 63055009
Immunodeficiency 37.38 10.06 246 420089 20008 63048679
Bronchial haemorrhage 37.03 10.06 31 420304 561 63068126
Lymphopenia 36.96 10.06 40 420295 18287 63050400
Thrombotic microangiopathy 36.78 10.06 12 420323 10549 63058138
Progressive multifocal leukoencephalopathy 36.74 10.06 20 420315 12951 63055736
Myelodysplastic syndrome 36.73 10.06 34 420301 16720 63051967
Idiopathic intracranial hypertension 36.68 10.06 68 420267 2863 63065824
Sputum retention 36.58 10.06 31 420304 571 63068116
Gamma-glutamyltransferase increased 36.45 10.06 110 420225 33921 63034766
Circumstance or information capable of leading to device use error 36.32 10.06 18 420317 122 63068565
Device ineffective 36.25 10.06 22 420313 232 63068455
Renal failure 35.87 10.06 555 419780 117097 62951590
Feeling abnormal 35.81 10.06 1259 419076 147133 62921554
Sarcoidosis 35.58 10.06 116 420219 7006 63061681
Embolism venous 35.56 10.06 70 420265 3084 63065603
Salpingo-oophorectomy unilateral 35.36 10.06 36 420299 845 63067842
Drug level increased 35.35 10.06 60 420275 22676 63046011
Ulcer 35.24 10.06 75 420260 26032 63042655
Acute myeloid leukaemia 35.05 10.06 37 420298 17110 63051577
Rash maculo-papular 34.96 10.06 102 420233 31794 63036893
Acute hepatic failure 34.79 10.06 42 420293 18285 63050402
Anuria 34.62 10.06 20 420315 12531 63056156
Intentional self-injury 34.50 10.06 74 420261 25613 63043074
Angioedema 34.25 10.06 476 419859 47489 63021198
Respiratory gas exchange disorder 33.89 10.06 25 420310 373 63068314
Pulmonary congestion 33.64 10.06 214 420121 17204 63051483
Liver disorder 33.39 10.06 213 420122 53474 63015213
Sinus congestion 33.37 10.06 220 420115 17903 63050784
Ill-defined disorder 33.28 10.06 363 419972 81392 62987295
Diarrhoea 33.26 10.06 4189 416146 711177 62357510
Respiratory failure 33.04 10.06 896 419439 100962 62967725
Bradycardia 32.74 10.06 318 420017 72909 62995778
Malignant mediastinal neoplasm 32.68 10.06 44 420291 1402 63067285
Carpal tunnel syndrome 32.64 10.06 243 420092 20574 63048113
Myalgia 32.62 10.06 1232 419103 145297 62923390
Blood lactic acid increased 32.38 10.06 112 420223 6974 63061713
Hypercapnia 32.29 10.06 94 420241 5337 63063350
Breath alcohol test positive 32.19 10.06 8 420327 0 63068687
Status epilepticus 32.12 10.06 32 420303 15201 63053486
Device deposit issue 31.69 10.06 11 420324 24 63068663
Hepatic failure 31.61 10.06 125 420210 35531 63033156
Joint stiffness 31.54 10.06 156 420179 41713 63026974
Aspirin-exacerbated respiratory disease 31.33 10.06 34 420301 861 63067826
Broncholithiasis 31.27 10.06 20 420315 233 63068454
Ear pruritus 31.05 10.06 76 420259 3889 63064798
Skin necrosis 30.95 10.06 28 420307 13922 63054765
Ear congestion 30.82 10.06 61 420274 2698 63065989
Encephalopathy 30.78 10.06 141 420194 38479 63030208
Pulmonary toxicity 30.78 10.06 12 420323 9443 63059244
Device expulsion 30.59 10.06 123 420212 34799 63033888
Rhinovirus infection 30.48 10.06 82 420253 4447 63064240
Blood iron decreased 30.40 10.06 184 420151 14537 63054150
Rubber sensitivity 30.33 10.06 55 420280 2276 63066411
Sinus tachycardia 30.32 10.06 269 420066 23999 63044688
Ventricular failure 30.20 10.06 23 420312 361 63068326
Retinitis 30.18 10.06 3 420332 6193 63062494
Ventilation perfusion mismatch 30.10 10.06 26 420309 492 63068195
Febrile bone marrow aplasia 29.96 10.06 6 420329 7319 63061368
Nephrectomy 29.78 10.06 43 420292 1465 63067222
Skin candida 29.53 10.06 45 420290 1610 63067077
Rib deformity 29.49 10.06 20 420315 259 63068428
FEV1/FVC ratio decreased 29.40 10.06 15 420320 109 63068578
Sputum abnormal 29.40 10.06 30 420305 706 63067981
Ascites 29.40 10.06 154 420181 40574 63028113
Rebound nasal congestion 29.39 10.06 10 420325 20 63068667
Therapy partial responder 29.37 10.06 17 420318 10641 63058046
Hypercalcaemia 29.31 10.06 93 420242 28229 63040458
Extrapyramidal disorder 29.07 10.06 27 420308 13257 63055430
Pregnancy 29.05 10.06 135 420200 36701 63031986
Hypertensive crisis 29.05 10.06 35 420300 15251 63053436
Respiratory tract irritation 29.01 10.06 24 420311 427 63068260
Airway remodelling 28.68 10.06 13 420322 70 63068617
Panic attack 28.66 10.06 249 420086 22082 63046605
Lymph node calcification 28.60 10.06 21 420314 311 63068376
Distal intestinal obstruction syndrome 28.47 10.06 23 420312 395 63068292
Nicotine dependence 28.23 10.06 29 420306 688 63067999
Polyneuropathy 28.15 10.06 33 420302 14556 63054131
Chills 28.11 10.06 965 419370 112413 62956274
Live birth 28.06 10.06 82 420253 25548 63043139
Joint destruction 28.05 10.06 4 420331 6248 63062439
Lupus-like syndrome 28.04 10.06 36 420299 15259 63053428
Depressed mood 27.95 10.06 397 419938 39794 63028893
Enthesopathy 27.93 10.06 11 420324 8603 63060084
Deformity 27.70 10.06 22 420313 11662 63057025
Cardiac murmur 27.62 10.06 178 420157 14374 63054313
Device information output issue 27.59 10.06 15 420320 126 63068561
Injection site reaction 27.08 10.06 252 420083 58272 63010415
Exercise tolerance decreased 26.99 10.06 89 420246 5408 63063279
Uveitis 26.90 10.06 26 420309 12527 63056160
Hyposmia 26.77 10.06 28 420307 679 63068008
Cardiac failure 26.66 10.06 422 419913 88720 62979967
Toxic skin eruption 26.12 10.06 28 420307 12857 63055830
Exostosis 26.09 10.06 49 420286 17813 63050874
Cardiac arrest 26.07 10.06 443 419892 92102 62976585
Metastases to central nervous system 25.99 10.06 29 420306 13076 63055611
Anosmia 25.95 10.06 102 420233 6758 63061929
Proctitis 25.57 10.06 3 420332 5438 63063249
Colitis 25.56 10.06 202 420133 48326 63020361
Blood creatinine increased 25.56 10.06 418 419917 87426 62981261
Chronic respiratory failure 25.41 10.06 46 420289 1901 63066786
Tracheomalacia 25.27 10.06 16 420319 183 63068504
Urosepsis 25.18 10.06 53 420282 18471 63050216
Expired product administered 25.10 10.06 94 420241 6087 63062600
Vocal cord disorder 25.03 10.06 38 420297 1355 63067332
Proteinuria 25.01 10.06 56 420279 19089 63049598
Generalised tonic-clonic seizure 24.91 10.06 103 420232 28913 63039774
Cytokine release syndrome 24.91 10.06 35 420300 14279 63054408
Polymyalgia rheumatica 24.88 10.06 68 420267 3723 63064964
Rectal prolapse 24.81 10.06 46 420289 1937 63066750
Hypoalbuminaemia 24.66 10.06 25 420310 11780 63056907
Oesophageal spasm 24.60 10.06 60 420275 3063 63065624
Nasal inflammation 24.58 10.06 23 420312 485 63068202
Obstruction 24.55 10.06 60 420275 3067 63065620
Endometrial ablation 24.38 10.06 31 420304 933 63067754
Aphthous ulcer 24.34 10.06 34 420301 13904 63054783
Tuberculosis 24.28 10.06 23 420312 11188 63057499
Rib fracture 24.00 10.06 242 420093 22355 63046332
Hypertransaminasaemia 23.93 10.06 7 420328 6602 63062085
Pneumonia respiratory syncytial viral 23.81 10.06 32 420303 1018 63067669
Crepitations 23.81 10.06 111 420224 7929 63060758
Suspected suicide 23.70 10.06 7 420328 6561 63062126
Intentional device misuse 23.70 10.06 28 420307 780 63067907
Painful respiration 23.69 10.06 55 420280 2719 63065968
Hepatic cirrhosis 23.69 10.06 84 420251 24650 63044037
Nasal septum deviation 23.59 10.06 39 420296 1497 63067190
Choking sensation 23.57 10.06 64 420271 3490 63065197
Bladder pain 23.38 10.06 49 420286 2259 63066428
Pulmonary pain 23.30 10.06 63 420272 3427 63065260
Pain 23.28 10.06 4436 415899 736192 62332495
Occupational asthma 23.20 10.06 14 420321 146 63068541
Grip strength decreased 23.19 10.06 73 420262 22214 63046473
Ischaemic stroke 23.07 10.06 53 420282 17904 63050783
Bronchomalacia 23.03 10.06 16 420319 216 63068471
Graft versus host disease 23.00 10.06 8 420327 6755 63061932
Blood insulin abnormal 23.00 10.06 9 420326 31 63068656
Adverse drug reaction 22.97 10.06 380 419955 79334 62989353
Bronchiolitis 22.96 10.06 54 420281 2693 63065994
Nocturnal dyspnoea 22.86 10.06 34 420301 1190 63067497
Facet joint syndrome 22.84 10.06 28 420307 12110 63056577
Herpes zoster 22.82 10.06 396 419939 82066 62986621
Infusion site extravasation 22.61 10.06 132 420203 10294 63058393
Bradyphrenia 22.49 10.06 9 420326 6971 63061716
Enterocolitis 22.43 10.06 12 420323 7846 63060841
Bone density decreased 22.31 10.06 39 420296 14573 63054114
Pyrexia 22.29 10.06 2751 417584 467727 62600960
Infusion site pruritus 22.24 10.06 89 420246 5946 63062741
Oropharyngeal discomfort 22.20 10.06 81 420254 5179 63063508
Foreign body aspiration 22.20 10.06 15 420320 193 63068494
C-reactive protein 22.19 10.06 3 420332 4879 63063808
Bronchitis bacterial 22.19 10.06 28 420307 836 63067851
Lip dry 22.11 10.06 43 420292 15427 63053260
Influenza like illness 22.00 10.06 589 419746 66235 63002452
Gastrointestinal toxicity 21.83 10.06 12 420323 7729 63060958
Haemoglobin decreased 21.77 10.06 766 419569 144719 62923968
Superinfection 21.52 10.06 51 420284 2556 63066131
Hyperhidrosis 21.50 10.06 896 419439 106940 62961747
Device defective 21.46 10.06 43 420292 1919 63066768
Body temperature abnormal 21.46 10.06 44 420291 1997 63066690
Pharyngeal oedema 21.42 10.06 160 420175 13561 63055126
Neutrophilia 21.33 10.06 71 420264 4335 63064352
Impaired work ability 21.32 10.06 53 420282 17422 63051265
Rhabdomyolysis 21.31 10.06 187 420148 43764 63024923
Separation anxiety disorder 21.26 10.06 8 420327 24 63068663
Basal cell carcinoma 21.25 10.06 104 420231 27887 63040800
Nasal oedema 21.20 10.06 37 420298 1485 63067202
Labelled drug-drug interaction medication error 21.16 10.06 35 420300 13364 63055323
Diffuse large B-cell lymphoma 21.07 10.06 9 420326 6703 63061984
Respiratory tract infection viral 20.94 10.06 46 420289 2191 63066496
Sciatica 20.93 10.06 137 420198 34187 63034500
Candida infection 20.91 10.06 283 420052 28068 63040619
Functional residual capacity increased 20.89 10.06 11 420324 86 63068601
Thunderclap headache 20.78 10.06 15 420320 216 63068471
Skin laceration 20.77 10.06 236 420099 22472 63046215
Akathisia 20.72 10.06 18 420317 9128 63059559
Blood potassium decreased 20.63 10.06 392 419943 41634 63027053
Asthma exercise induced 20.61 10.06 17 420318 301 63068386
Haemophagocytic lymphohistiocytosis 20.55 10.06 24 420311 10603 63058084
Pharyngitis streptococcal 20.54 10.06 131 420204 10541 63058146
Fracture 20.48 10.06 64 420271 19520 63049167
Stress urinary incontinence 20.45 10.06 47 420288 2308 63066379
Breast cancer stage I 20.44 10.06 10 420325 6879 63061808
Cytomegalovirus viraemia 20.42 10.06 6 420329 5643 63063044
Gallbladder injury 20.36 10.06 35 420300 1388 63067299
Haemorrhage intracranial 20.33 10.06 36 420299 13383 63055304
Nystagmus 20.07 10.06 8 420327 6212 63062475
Bronchitis chronic 20.06 10.06 69 420266 4284 63064403
Infusion site pain 20.06 10.06 185 420150 16684 63052003
Respiratory arrest 20.05 10.06 130 420205 32515 63036172
Mouth swelling 20.01 10.06 73 420262 4667 63064020
Pneumonia aspiration 19.99 10.06 140 420195 34400 63034287
Breast cancer female 19.98 10.06 37 420298 13522 63055165
Tongue pruritus 19.82 10.06 21 420314 517 63068170
Seizure 19.69 10.06 699 419636 131935 62936752
Purpura 19.65 10.06 28 420307 11357 63057330
Wound complication 19.60 10.06 62 420273 3685 63065002
Metastases to lung 19.50 10.06 34 420301 12716 63055971
Nasal pruritus 19.49 10.06 20 420315 474 63068213
Soft tissue disorder 19.44 10.06 3 420332 4419 63064268
Cervix neoplasm 19.31 10.06 14 420321 203 63068484
Red blood cell count decreased 19.24 10.06 174 420161 40471 63028216
Musculoskeletal disorder 19.18 10.06 71 420264 20573 63048114
Magnetic resonance imaging thoracic abnormal 19.11 10.06 7 420328 19 63068668
Heart sounds 19.08 10.06 28 420307 968 63067719
Multiple sclerosis relapse 19.03 10.06 217 420118 48261 63020426
Osteomyelitis 18.99 10.06 98 420237 25922 63042765
Inappropriate schedule of product administration 18.98 10.06 856 419479 103109 62965578
Dermatitis allergic 18.97 10.06 168 420167 14980 63053707
Pre-existing condition improved 18.94 10.06 106 420229 8138 63060549
Cockroach allergy 18.79 10.06 9 420326 56 63068631
Overweight 18.65 10.06 61 420274 3690 63064997
Forced expiratory volume increased 18.60 10.06 7 420328 21 63068666
Neuroleptic malignant syndrome 18.57 10.06 32 420303 12024 63056663
Bacterial infection 18.45 10.06 204 420131 19295 63049392
Nasal disorder 18.42 10.06 51 420284 2813 63065874
PCO2 increased 18.42 10.06 31 420304 1208 63067479
Incorrect dose administered by device 18.39 10.06 67 420268 4281 63064406
Haemolytic anaemia 18.38 10.06 24 420311 10101 63058586
Skin ulcer 18.38 10.06 189 420146 42856 63025831
Pneumothorax spontaneous 18.28 10.06 25 420310 809 63067878
Stress 18.26 10.06 578 419757 66589 63002098
Lacrimation increased 18.24 10.06 213 420122 20418 63048269
Pneumonia pseudomonal 18.21 10.06 47 420288 2486 63066201
Disorientation 18.20 10.06 170 420165 39282 63029405
Cardiac failure congestive 18.19 10.06 767 419568 91666 62977021
Colitis microscopic 18.16 10.06 21 420314 9318 63059369
Peripheral venous disease 18.07 10.06 48 420287 15429 63053258
Decreased bronchial secretion 18.04 10.06 9 420326 62 63068625
Unintentional medical device removal 17.95 10.06 9 420326 6106 63062581
Pathogen resistance 17.92 10.06 10 420325 6388 63062299
Wound secretion 17.77 10.06 69 420266 4545 63064142
Carbon dioxide increased 17.75 10.06 32 420303 1318 63067369
Transaminases increased 17.74 10.06 128 420207 31239 63037448
Anhedonia 17.72 10.06 129 420206 10845 63057842
Nervousness 17.70 10.06 296 420039 30683 63038004
Peripheral sensory neuropathy 17.70 10.06 14 420321 7437 63061250
Osteoarthritis 17.67 10.06 488 419847 94855 62973832
Oropharyngitis fungal 17.66 10.06 8 420327 43 63068644
Crying 17.62 10.06 234 420101 23109 63045578
Allergic cough 17.62 10.06 23 420312 711 63067976
Blood pressure fluctuation 17.54 10.06 209 420126 46108 63022579
Postural orthostatic tachycardia syndrome 17.52 10.06 31 420304 1258 63067429
Increased viscosity of bronchial secretion 17.51 10.06 16 420319 327 63068360
Infusion site urticaria 17.49 10.06 35 420300 1561 63067126
Tremor 17.48 10.06 1056 419279 131183 62937504
Oxygen consumption increased 17.41 10.06 61 420274 3823 63064864
Metastases to lymph nodes 17.36 10.06 17 420318 8141 63060546
Peak expiratory flow rate abnormal 17.36 10.06 10 420325 95 63068592
Scleritis 17.35 10.06 4 420331 4424 63064263
Pemphigoid 17.19 10.06 14 420321 7330 63061357
Skin toxicity 17.05 10.06 5 420330 4709 63063978
Electrocardiogram QRS complex prolonged 17.05 10.06 9 420326 5929 63062758
Ovarian hyperstimulation syndrome 17.03 10.06 3 420332 4011 63064676
Colitis ulcerative 17.01 10.06 102 420233 25989 63042698
Oral pruritus 16.98 10.06 43 420292 2248 63066439
Venous pressure jugular increased 16.93 10.06 20 420315 557 63068130
Epstein-Barr virus infection 16.87 10.06 17 420318 8033 63060654
Suspected COVID-19 16.86 10.06 46 420289 2516 63066171
Breast cancer recurrent 16.85 10.06 4 420331 4337 63064350
Essential hypertension 16.80 10.06 72 420263 4961 63063726
Diastolic dysfunction 16.77 10.06 86 420249 6385 63062302
Exposure to toxic agent 16.74 10.06 8 420327 5579 63063108
Respiratory syncytial virus infection 16.64 10.06 91 420244 6927 63061760
Breast conserving surgery 16.61 10.06 27 420308 1022 63067665
Brain oedema 16.59 10.06 44 420291 14151 63054536
Muscle spasms 16.56 10.06 1224 419111 154926 62913761
Dyspnoea at rest 16.54 10.06 62 420273 4017 63064670
Lip discolouration 16.52 10.06 20 420315 572 63068115
Functional residual capacity decreased 16.51 10.06 9 420326 76 63068611
Oesophageal pain 16.48 10.06 58 420277 3643 63065044
Ear discomfort 16.44 10.06 99 420236 7807 63060880
Shock haemorrhagic 16.43 10.06 25 420310 9870 63058817
Neurosensory hypoacusis 16.40 10.06 13 420322 217 63068470
Aplasia 16.39 10.06 4 420331 4255 63064432
Hyperprolactinaemia 16.36 10.06 3 420332 3897 63064790
Abortion spontaneous 16.36 10.06 217 420118 46978 63021709
Immune reconstitution inflammatory syndrome 16.35 10.06 10 420325 6074 63062613
Product prescribing issue 16.32 10.06 47 420288 2652 63066035
Insurance issue 16.32 10.06 82 420253 6039 63062648
Subdural haematoma 16.31 10.06 45 420290 14283 63054404
Depressed level of consciousness 16.30 10.06 532 419803 61546 63007141
Duodenal ulcer repair 16.29 10.06 8 420327 53 63068634
Tobacco abuse 16.27 10.06 22 420313 704 63067983
Oxygen therapy 16.27 10.06 41 420294 2137 63066550
Sinonasal obstruction 16.25 10.06 14 420321 264 63068423
Sinus headache 16.24 10.06 77 420258 5539 63063148
Erysipelas 16.22 10.06 17 420318 7888 63060799
Thyroid atrophy 16.20 10.06 6 420329 17 63068670
Product availability issue 16.18 10.06 62 420273 4059 63064628
Infusion site bruising 16.17 10.06 59 420276 3773 63064914
Endometriosis 16.16 10.06 74 420261 5246 63063441
Lower limb fracture 16.16 10.06 94 420241 24127 63044560
Body mass index increased 16.15 10.06 29 420306 1191 63067496
Eye swelling 16.13 10.06 235 420100 23683 63045004
Red cell distribution width abnormal 16.12 10.06 11 420324 144 63068543
Pneumonectomy 16.10 10.06 4 420331 0 63068687
Drug ineffective for unapproved indication 16.05 10.06 146 420189 33917 63034770
Biliary dyskinesia 16.00 10.06 47 420288 2682 63066005
Bacterial tracheitis 15.95 10.06 6 420329 18 63068669
Nonspecific reaction 15.93 10.06 42 420293 2250 63066437
Alanine aminotransferase abnormal 15.89 10.06 5 420330 4499 63064188
Eosinophilic pneumonia chronic 15.88 10.06 12 420323 186 63068501
Klebsiella infection 15.87 10.06 20 420315 8546 63060141
Aplasia pure red cell 15.80 10.06 5 420330 4482 63064205
Enteritis 15.71 10.06 19 420316 8267 63060420
CFTR gene mutation 15.67 10.06 10 420325 116 63068571
Tension headache 15.65 10.06 72 420263 5114 63063573
Uterine perforation 15.65 10.06 89 420246 6874 63061813
Muscle rigidity 15.55 10.06 33 420302 11467 63057220
Mast cell activation syndrome 15.53 10.06 23 420312 802 63067885
Osteonecrosis 15.42 10.06 97 420238 24433 63044254
Oesophageal dilatation 15.39 10.06 16 420319 385 63068302
Peritonitis 15.29 10.06 60 420275 17094 63051593
Tricuspid valve incompetence 15.25 10.06 156 420179 14465 63054222
Respiratory acidosis 15.20 10.06 86 420249 6629 63062058
Cardiogenic shock 15.18 10.06 64 420271 17868 63050819
Breast cancer 15.16 10.06 227 420108 48156 63020531
Dislocation of vertebra 15.14 10.06 21 420314 8614 63060073
Radioallergosorbent test positive 15.11 10.06 7 420328 40 63068647
Hyperkalaemia 15.09 10.06 260 420075 53943 63014744
Malignant melanoma 15.01 10.06 33 420302 11323 63057364
Ataxia 14.96 10.06 51 420284 15144 63053543
Hyperammonaemia 14.92 10.06 8 420327 5224 63063463
Hyperbilirubinaemia 14.86 10.06 33 420302 11281 63057406
Self-injurious ideation 14.84 10.06 45 420290 2614 63066073
Paranasal sinus hypersecretion 14.82 10.06 57 420278 3738 63064949
Carcinoid tumour pulmonary 14.75 10.06 17 420318 461 63068226
Metastasis 14.74 10.06 8 420327 5189 63063498
Red blood cell sedimentation rate abnormal 14.73 10.06 74 420261 19708 63048979
Nasal mucosal discolouration 14.69 10.06 5 420330 10 63068677
Small airways disease 14.69 10.06 5 420330 10 63068677
Obstructive pancreatitis 14.69 10.06 16 420319 407 63068280
Tumour lysis syndrome 14.65 10.06 23 420312 8967 63059720
Lupus vulgaris 14.57 10.06 11 420324 5983 63062704
Paraesthesia oral 14.53 10.06 193 420142 19063 63049624
Product prescribing error 14.52 10.06 108 420227 26181 63042506
Symptom recurrence 14.50 10.06 35 420300 1775 63066912
Infusion site mass 14.48 10.06 38 420297 2030 63066657
Atopy 14.46 10.06 13 420322 260 63068427
Pulmonary thrombosis 14.46 10.06 103 420232 8599 63060088
Influenza B virus test positive 14.46 10.06 13 420322 260 63068427
Ileus paralytic 14.45 10.06 6 420329 4545 63064142
Therapeutic response decreased 14.39 10.06 304 420031 61221 63007466
Loss of consciousness 14.39 10.06 637 419698 117484 62951203
Jaundice 14.38 10.06 124 420211 29127 63039560
Lung consolidation 14.36 10.06 60 420275 4088 63064599
Injection site scab 14.35 10.06 16 420319 418 63068269
Quarantine 14.30 10.06 7 420328 46 63068641
Arthritis bacterial 14.30 10.06 13 420322 6450 63062237
Product administration error 14.30 10.06 218 420117 22179 63046508
Deep vein thrombosis postoperative 14.25 10.06 34 420301 11335 63057352
Dehydration 14.23 10.06 972 419363 172382 62896305
Aplastic anaemia 14.20 10.06 26 420309 9543 63059144
PO2 decreased 14.14 10.06 31 420304 1475 63067212
Sepsis 14.04 10.06 850 419485 152273 62916414
Myocardial infarction 14.02 10.06 802 419533 99091 62969596
Mydriasis 14.02 10.06 37 420298 11919 63056768
Respiratory syncytial virus bronchiolitis 14.01 10.06 14 420321 321 63068366
Crystal arthropathy 13.98 10.06 14 420321 322 63068365
Sinus polyp degeneration 13.94 10.06 7 420328 49 63068638
Stridor 13.94 10.06 53 420282 3457 63065230
Pulmonary hypertension 13.92 10.06 333 420002 36790 63031897
Contusion 13.91 10.06 832 419503 149212 62919475
Hepatitis cholestatic 13.88 10.06 15 420320 6863 63061824
Administration site inflammation 13.88 10.06 4 420331 3 63068684
Upper airway obstruction 13.81 10.06 20 420315 683 63068004
Tenosynovitis 13.78 10.06 46 420289 13749 63054938
Angle closure glaucoma 13.77 10.06 39 420296 2180 63066507
Oxygen consumption decreased 13.77 10.06 12 420323 230 63068457
Joint effusion 13.76 10.06 62 420273 16998 63051689
SARS-CoV-2 test positive 13.76 10.06 96 420239 7960 63060727
Retching 13.75 10.06 153 420182 14492 63054195
Pneumococcal infection 13.73 10.06 16 420319 439 63068248
Sleep terror 13.70 10.06 44 420291 2636 63066051
Spinal pain 13.69 10.06 43 420292 13096 63055591
Decreased activity 13.69 10.06 80 420255 6240 63062447
Central obesity 13.65 10.06 27 420308 1194 63067493
Nasal turbinate abnormality 13.59 10.06 6 420329 30 63068657
Appetite disorder 13.56 10.06 89 420246 7232 63061455
Stevens-Johnson syndrome 13.54 10.06 103 420232 24847 63043840
Nightmare 13.51 10.06 190 420145 19004 63049683
Laryngeal stenosis 13.48 10.06 25 420310 1053 63067634
Eosinophilic oesophagitis 13.47 10.06 14 420321 337 63068350
Drug administered in wrong device 13.44 10.06 6 420329 31 63068656
Varicella zoster gastritis 13.44 10.06 6 420329 31 63068656
Aspiration 13.41 10.06 120 420215 10731 63057956
Anti-cyclic citrullinated peptide antibody 13.35 10.06 15 420320 6743 63061944
Blood alkaline phosphatase increased 13.32 10.06 202 420133 42765 63025922
Cachexia 13.30 10.06 11 420324 5715 63062972
Forced expiratory volume 13.29 10.06 5 420330 15 63068672
Device use issue 13.29 10.06 43 420292 2587 63066100
Sleep disorder 13.27 10.06 664 419671 80902 62987785
Metabolic acidosis 13.26 10.06 214 420121 44855 63023832
Laryngeal pain 13.25 10.06 62 420273 4436 63064251
Factitious disorder 13.21 10.06 8 420327 84 63068603
Adverse reaction 13.20 10.06 30 420305 10173 63058514
Neuromyotonia 13.06 10.06 7 420328 57 63068630
Endocrine ophthalmopathy 13.05 10.06 19 420316 652 63068035
Carbon dioxide abnormal 13.02 10.06 10 420325 159 63068528
Frequent bowel movements 12.99 10.06 94 420241 22928 63045759
Kidney transplant rejection 12.98 10.06 6 420329 4265 63064422
Prescribed overdose 12.97 10.06 154 420181 33999 63034688
Muscle tension dysphonia 12.96 10.06 11 420324 203 63068484
Colorectal cancer 12.94 10.06 4 420331 3641 63065046
Wolff-Parkinson-White syndrome 12.92 10.06 9 420326 122 63068565
Oesophagogastroduodenoscopy 12.92 10.06 10 420325 161 63068526
Supraventricular tachycardia 12.91 10.06 148 420187 14123 63054564
Concussion 12.88 10.06 105 420230 9139 63059548
Diabetes mellitus 12.83 10.06 471 419864 55339 63013348
Nasal flaring 12.83 10.06 5 420330 17 63068670
Diastolic hypotension 12.82 10.06 8 420327 89 63068598
Femoral neck fracture 12.79 10.06 23 420312 8500 63060187
BK virus infection 12.77 10.06 3 420332 3276 63065411
Pickwickian syndrome 12.76 10.06 14 420321 359 63068328
Hysterectomy 12.76 10.06 107 420228 9392 63059295
Gastroenteritis viral 12.65 10.06 224 420111 23476 63045211
Cor pulmonale 12.65 10.06 36 420299 2018 63066669
Delirium 12.64 10.06 247 420088 50294 63018393
Increased viscosity of upper respiratory secretion 12.61 10.06 10 420325 167 63068520
Use of accessory respiratory muscles 12.60 10.06 12 420323 259 63068428
Pharyngeal erythema 12.60 10.06 32 420303 1676 63067011
Intestinal perforation 12.58 10.06 39 420296 11924 63056763
Mycobacterium avium complex infection 12.57 10.06 47 420288 3041 63065646
Cerebrovascular arteriovenous malformation 12.52 10.06 8 420327 93 63068594
Caesarean section 12.52 10.06 64 420271 16968 63051719
Blood electrolytes abnormal 12.51 10.06 24 420311 1037 63067650
Premature delivery 12.50 10.06 134 420201 30147 63038540
Lung operation 12.49 10.06 12 420323 262 63068425
Blood iron abnormal 12.48 10.06 5 420330 3871 63064816
Psychomotor retardation 12.45 10.06 5 420330 3865 63064822
Finger deformity 12.45 10.06 20 420315 7725 63060962
Hilar lymphadenopathy 12.44 10.06 26 420309 1196 63067491
Generalised anxiety disorder 12.43 10.06 36 420299 2038 63066649
Hypocalcaemia 12.43 10.06 142 420193 31571 63037116
Oliguria 12.40 10.06 26 420309 9075 63059612
Gastric cancer 12.36 10.06 8 420327 4715 63063972
Cerebellar syndrome 12.36 10.06 4 420331 3535 63065152
Atypical fracture 12.36 10.06 18 420317 618 63068069
Kyphosis 12.36 10.06 41 420294 2499 63066188
Foetal death 12.35 10.06 119 420216 10861 63057826
Clubbing 12.33 10.06 15 420320 431 63068256
Left ventricular failure 12.33 10.06 72 420263 5615 63063072
Mucosal discolouration 12.32 10.06 16 420319 492 63068195
Accidental overdose 12.29 10.06 97 420238 23212 63045475
Ventricular arrhythmia 12.23 10.06 5 420330 3823 63064864
Liver function test abnormal 12.19 10.06 235 420100 47946 63020741
Peripheral vascular disorder 12.19 10.06 75 420260 5960 63062727
Cholecystectomy 12.15 10.06 116 420219 10561 63058126
Inspiratory capacity decreased 12.11 10.06 7 420328 67 63068620
Infusion site haemorrhage 12.09 10.06 66 420269 5020 63063667
Weight 12.07 10.06 3 420332 0 63068687
Noninfective bronchitis 12.07 10.06 3 420332 0 63068687
Breast cancer metastatic 12.06 10.06 40 420295 11978 63056709
Ketoacidosis 12.04 10.06 7 420328 4371 63064316
Bronchoscopy 12.02 10.06 7 420328 68 63068619
Inappropriate antidiuretic hormone secretion 12.00 10.06 57 420278 15405 63053282
Dyspnoea paroxysmal nocturnal 11.99 10.06 22 420313 919 63067768
Demyelination 11.96 10.06 17 420318 6903 63061784
Trifascicular block 11.90 10.06 8 420327 102 63068585
Lactose intolerance 11.85 10.06 45 420290 2933 63065754
Accidental exposure to product 11.83 10.06 120 420215 27285 63041402
Cystic fibrosis related diabetes 11.83 10.06 6 420329 43 63068644
Sinus polyp 11.82 10.06 14 420321 391 63068296
Atelectasis 11.81 10.06 204 420131 21279 63047408
Hypothermia 11.79 10.06 48 420287 13533 63055154
Hyperthermia 11.78 10.06 27 420308 9129 63059558
Ear infection 11.78 10.06 334 420001 37879 63030808
Total lung capacity abnormal 11.76 10.06 7 420328 71 63068616
Lipohypertrophy 11.75 10.06 18 420317 647 63068040
Intentional product misuse 11.75 10.06 310 420025 60607 63008080
Ejection fraction decreased 11.74 10.06 93 420242 22239 63046448
Airway peak pressure increased 11.74 10.06 12 420323 283 63068404
Neutropenic colitis 11.73 10.06 3 420332 3092 63065595
Snoring 11.71 10.06 57 420278 4145 63064542
Breath sounds 11.64 10.06 8 420327 106 63068581
Blood creatine phosphokinase increased 11.64 10.06 137 420198 30293 63038394
Hypervolaemia 11.63 10.06 258 420077 28155 63040532
Excessive eye blinking 11.62 10.06 26 420309 1254 63067433
Deep vein thrombosis 11.60 10.06 672 419663 83128 62985559
Amylase increased 11.56 10.06 15 420320 6330 63062357
Lower respiratory tract infection bacterial 11.56 10.06 15 420320 461 63068226
Coagulopathy 11.53 10.06 84 420251 20460 63048227
Burns third degree 11.50 10.06 12 420323 290 63068397
Myopathy 11.48 10.06 119 420216 11072 63057615
Cerebral haematoma 11.46 10.06 5 420330 3678 63065009
Vaccination site erythema 11.44 10.06 7 420328 75 63068612
Hypoacusis 11.42 10.06 224 420111 23927 63044760
Pathological fracture 11.41 10.06 26 420309 8808 63059879
Blood magnesium increased 11.41 10.06 3 420332 3035 63065652
Eye paraesthesia 11.32 10.06 9 420326 151 63068536
Nail disorder 11.30 10.06 46 420289 12969 63055718
Tachypnoea 11.28 10.06 169 420166 17133 63051554
Blood immunoglobulin E decreased 11.21 10.06 7 420328 78 63068609
Electrocardiogram QT prolonged 11.20 10.06 304 420031 59226 63009461
Upper respiratory tract congestion 11.20 10.06 35 420300 2067 63066620
Mania 11.19 10.06 43 420292 12324 63056363
Tympanoplasty 11.17 10.06 5 420330 26 63068661
Laboratory test abnormal 11.15 10.06 119 420216 26793 63041894
Coordination abnormal 11.14 10.06 50 420285 13723 63054964
Toxic shock syndrome 11.13 10.06 20 420315 822 63067865
Hyperventilation 11.11 10.06 74 420261 6042 63062645
Drug use disorder 11.06 10.06 10 420325 4974 63063713
Cystic fibrosis lung 11.04 10.06 8 420327 116 63068571
Acute sinusitis 11.03 10.06 53 420282 3834 63064853
Wrist fracture 11.02 10.06 138 420197 13449 63055238
Paranoia 10.96 10.06 122 420213 11557 63057130
Pulmonary oedema 10.95 10.06 456 419879 54417 63014270
Pollakiuria 10.91 10.06 252 420083 27685 63041002
Local reaction 10.89 10.06 18 420317 691 63067996
Dyslipidaemia 10.86 10.06 85 420250 7308 63061379
Hyperreflexia 10.84 10.06 14 420321 5920 63062767
Hepatitis toxic 10.80 10.06 4 420331 3249 63065438
Aggression 10.79 10.06 217 420118 23281 63045406
Circulatory collapse 10.79 10.06 93 420242 21845 63046842
Graft versus host disease in gastrointestinal tract 10.74 10.06 4 420331 3237 63065450
Alveolitis 10.72 10.06 3 420332 2912 63065775
Hypercholesterolaemia 10.69 10.06 90 420245 21244 63047443
Bursitis 10.66 10.06 321 420014 36720 63031967
Graft versus host disease in skin 10.66 10.06 3 420332 2902 63065785
Sputum culture 10.64 10.06 11 420324 263 63068424
Acne cystic 10.63 10.06 15 420320 500 63068187
Dizziness 10.63 10.06 3095 417240 426830 62641857
Heart block congenital 10.63 10.06 4 420331 12 63068675
Activated partial thromboplastin time 10.63 10.06 4 420331 12 63068675
Product expiration date issue 10.63 10.06 4 420331 12 63068675
Gingival bleeding 10.61 10.06 45 420290 12542 63056145
Liver function test increased 10.61 10.06 153 420182 32658 63036029
Acute respiratory distress syndrome 10.60 10.06 102 420233 23432 63045255
Sexual dysfunction 10.60 10.06 8 420327 4351 63064336
Dermatitis exfoliative generalised 10.59 10.06 6 420329 3801 63064886
Walking aid user 10.53 10.06 36 420299 10681 63058006
Nasal cyst 10.50 10.06 6 420329 56 63068631
Rash macular 10.48 10.06 215 420120 23149 63045538
Apathy 10.48 10.06 27 420308 8767 63059920
Mucormycosis 10.47 10.06 3 420332 2868 63065819
Musculoskeletal chest pain 10.46 10.06 197 420138 20886 63047801
Gastrointestinal perforation 10.46 10.06 5 420330 3486 63065201
Wheelchair user 10.46 10.06 16 420319 6303 63062384
Partial seizures 10.45 10.06 14 420321 5828 63062859
Infusion site rash 10.44 10.06 33 420302 1961 63066726
Non-small cell lung cancer recurrent 10.43 10.06 7 420328 89 63068598
Poor quality product administered 10.42 10.06 45 420290 3111 63065576
Abnormal uterine bleeding 10.41 10.06 28 420307 1518 63067169
Pelvic pain 10.41 10.06 136 420199 13383 63055304
Tobacco user 10.40 10.06 19 420316 791 63067896
Eosinophil count decreased 10.34 10.06 35 420300 2155 63066532
Orthopnoea 10.34 10.06 74 420261 6187 63062500
PCO2 abnormal 10.33 10.06 6 420329 58 63068629
Dysphemia 10.30 10.06 40 420295 2635 63066052
Hypoaesthesia 10.30 10.06 967 419368 167426 62901261
Pneumothorax 10.28 10.06 158 420177 16103 63052584
Diverticulum 10.24 10.06 123 420212 11868 63056819
Gait disturbance 10.21 10.06 1059 419276 182119 62886568
Vertigo 10.21 10.06 310 420025 59577 63009110
Middle ear effusion 10.21 10.06 38 420297 2453 63066234
Metastases to peritoneum 10.20 10.06 5 420330 3437 63065250
Oral mucosal blistering 10.20 10.06 69 420266 5664 63063023
Haematochezia 10.19 10.06 273 420062 53271 63015416
Oropharyngeal spasm 10.18 10.06 11 420324 277 63068410
Mental disorder 10.18 10.06 234 420101 25685 63043002
Vision blurred 10.15 10.06 723 419612 91201 62977486
Scoliosis 10.14 10.06 88 420247 7800 63060887
Haemophilus infection 10.12 10.06 24 420311 1203 63067484
Blood pressure abnormal 10.12 10.06 149 420186 15049 63053638
Neck injury 10.11 10.06 34 420301 2087 63066600

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 3746.51 10.86 2624 207672 40032 34706603
Wheezing 2794.10 10.86 2174 208122 39228 34707407
Dyspnoea 1754.79 10.86 5596 204700 371186 34375449
Obstructive airways disorder 1233.28 10.86 899 209397 14595 34732040
Sleep disorder due to a general medical condition 1062.34 10.86 552 209744 4669 34741966
Cough 1029.41 10.86 2572 207724 147568 34599067
Full blood count abnormal 1022.76 10.86 869 209427 17799 34728836
Product quality issue 953.77 10.86 803 209493 16232 34730403
Chronic obstructive pulmonary disease 916.05 10.86 1292 209004 47626 34699009
Therapeutic product effect incomplete 853.28 10.86 1271 209025 49270 34697365
Productive cough 781.99 10.86 1048 209248 36765 34709870
Poor quality device used 742.26 10.86 261 210035 689 34745946
Infective pulmonary exacerbation of cystic fibrosis 639.31 10.86 437 209859 6364 34740271
Loss of personal independence in daily activities 554.82 10.86 831 209465 32348 34714287
Chest discomfort 544.67 10.86 1087 209209 53443 34693192
Forced expiratory volume decreased 515.75 10.86 290 210006 2913 34743722
Sputum discoloured 440.72 10.86 370 209926 7442 34739193
Completed suicide 389.49 10.86 62 210234 98106 34648529
Toxicity to various agents 383.71 10.86 384 209912 199978 34546657
Device delivery system issue 377.53 10.86 134 210162 367 34746268
Nasal congestion 307.54 10.86 521 209775 22536 34724099
Bronchiectasis 306.12 10.86 335 209961 9466 34737169
No adverse event 289.96 10.86 506 209790 22421 34724214
Off label use 286.03 10.86 1427 208869 418097 34328538
Dyspnoea exertional 279.38 10.86 726 209570 42553 34704082
Pulmonary function test decreased 271.10 10.86 231 210065 4744 34741891
Lower respiratory tract infection 264.84 10.86 587 209709 31050 34715585
Nasal polyps 259.61 10.86 171 210125 2332 34744303
Pneumonia 248.73 10.86 3296 207000 359331 34387304
Product dose omission issue 236.74 10.86 1377 208919 118334 34628301
Blood immunoglobulin E increased 235.47 10.86 162 210134 2384 34744251
Drug abuse 234.17 10.86 154 210142 98942 34647693
Cystic fibrosis 231.95 10.86 137 210159 1521 34745114
Drug interaction 225.06 10.86 658 209638 225288 34521347
Neutropenia 216.65 10.86 382 209914 156396 34590239
Respiratory disorder 204.22 10.86 394 209902 18870 34727765
Sinusitis 204.05 10.86 630 209666 40772 34705863
Febrile neutropenia 203.38 10.86 318 209978 136531 34610104
Bronchitis 194.38 10.86 625 209671 41338 34705297
Eosinophil count increased 191.58 10.86 247 210049 8325 34738310
Middle insomnia 191.04 10.86 220 210076 6582 34740053
Breath sounds abnormal 190.65 10.86 221 210075 6660 34739975
Asthma-chronic obstructive pulmonary disease overlap syndrome 173.92 10.86 104 210192 1183 34745452
Bronchospasm 169.66 10.86 262 210034 10469 34736166
Thrombocytopenia 162.79 10.86 445 209851 155802 34590833
Bronchopulmonary aspergillosis allergic 157.43 10.86 87 210209 842 34745793
Secretion discharge 155.86 10.86 185 210111 5720 34740915
Anaemia 149.18 10.86 810 209486 232525 34514110
Influenza 148.88 10.86 643 209653 49023 34697612
Pulmonary function test abnormal 147.98 10.86 124 210172 2486 34744149
Impaired quality of life 146.55 10.86 178 210118 5640 34740995
Eosinophil count abnormal 145.95 10.86 59 210237 255 34746380
Bronchial wall thickening 138.34 10.86 92 210204 1276 34745359
Hepatic function abnormal 136.65 10.86 48 210248 44315 34702320
Dust allergy 135.02 10.86 78 210218 828 34745807
Pancytopenia 134.84 10.86 228 210068 94929 34651706
Reversible airways obstruction 132.99 10.86 63 210233 426 34746209
Dermatitis atopic 122.52 10.86 156 210140 5191 34741444
Nasopharyngitis 121.76 10.86 779 209517 69189 34677446
Diarrhoea 118.15 10.86 1645 208651 388267 34358368
Bronchial obstruction 117.81 10.86 89 210207 1527 34745108
Obstruction 114.12 10.86 109 210187 2610 34744025
Eosinophilic granulomatosis with polyangiitis 113.89 10.86 95 210201 1892 34744743
Malignant neoplasm progression 113.12 10.86 224 210072 87822 34658813
Bronchial secretion retention 112.88 10.86 85 210211 1451 34745184
Blood test abnormal 109.91 10.86 170 210126 6801 34739834
Emphysema 109.86 10.86 202 210094 9323 34737312
Rhinorrhoea 109.61 10.86 372 209924 25296 34721339
Platelet count decreased 108.80 10.86 363 209933 119354 34627281
Lung consolidation 108.28 10.86 155 210141 5781 34740854
Sputum increased 107.12 10.86 99 210197 2271 34744364
Bronchial disorder 106.13 10.86 79 210217 1324 34745311
Upper-airway cough syndrome 104.86 10.86 118 210178 3440 34743195
Mucosal inflammation 102.58 10.86 52 210244 38570 34708065
Cytomegalovirus infection 102.46 10.86 17 210279 26118 34720517
Haemoptysis 102.43 10.86 450 209846 34556 34712079
Gastrooesophageal reflux disease 102.36 10.86 476 209820 37448 34709187
Bone marrow failure 102.25 10.86 25 210271 29228 34717407
Bronchial hyperreactivity 100.64 10.86 83 210213 1626 34745009
Nasal obstruction 99.90 10.86 58 210238 622 34746013
Leukopenia 99.16 10.86 140 210156 62716 34683919
Disease progression 98.00 10.86 328 209968 107749 34638886
Lung hyperinflation 97.03 10.86 63 210233 837 34745798
Asthmatic crisis 95.99 10.86 51 210245 453 34746182
Seasonal allergy 94.54 10.86 155 210141 6520 34740115
Intentional overdose 93.80 10.86 75 210221 43599 34703036
Chronic sinusitis 91.20 10.86 89 210207 2190 34744445
White blood cell count decreased 90.46 10.86 284 210012 95161 34651474
Respiratory tract congestion 90.27 10.86 145 210151 5994 34740641
Vital capacity decreased 90.06 10.86 45 210251 347 34746288
Sinus pain 88.63 10.86 55 210241 672 34745963
Hospitalisation 88.40 10.86 616 209680 56286 34690349
Drug resistance 87.10 10.86 24 210272 25903 34720732
Conjunctivitis allergic 86.54 10.86 65 210231 1105 34745530
Hypoxia 86.51 10.86 598 209698 54497 34692138
Spirometry abnormal 86.31 10.86 54 210242 670 34745965
Treatment failure 85.20 10.86 93 210203 46604 34700031
Upper respiratory tract infection 84.16 10.86 408 209888 32651 34713984
Myelosuppression 83.92 10.86 9 210287 19256 34727379
Coma 83.30 10.86 91 210205 45587 34701048
Lung disorder 82.51 10.86 420 209876 34276 34712359
Acute kidney injury 79.10 10.86 1325 208971 303663 34442972
Forced vital capacity decreased 78.02 10.86 52 210244 724 34745911
Malaise 77.88 10.86 1559 208737 184266 34562369
Oxygen saturation decreased 76.88 10.86 571 209725 53247 34693388
Stress 76.87 10.86 374 209922 29973 34716662
Respiratory rate increased 76.55 10.86 178 210118 9716 34736919
Mite allergy 75.34 10.86 49 210247 653 34745982
Renal impairment 74.41 10.86 304 209992 94209 34652426
Septic shock 72.90 10.86 207 210089 71627 34675008
Pyrexia 72.88 10.86 1490 208806 331523 34415112
Interstitial lung disease 72.41 10.86 180 210116 65102 34681533
Blood creatinine increased 71.98 10.86 310 209986 94666 34651969
Mycotic allergy 71.61 10.86 45 210251 563 34746072
Renal failure 71.26 10.86 476 209820 130081 34616554
Allergy to animal 71.23 10.86 39 210257 370 34746265
Sinus congestion 69.92 10.86 123 210173 5482 34741153
Right atrial hypertrophy 69.25 10.86 49 210247 756 34745879
Chest X-ray abnormal 68.98 10.86 107 210189 4291 34742344
Throat irritation 67.66 10.86 177 210119 10408 34736227
Neuropathy peripheral 66.05 10.86 267 210029 82996 34663639
Neutrophil count decreased 65.62 10.86 130 210166 50974 34695661
Pneumocystis jirovecii pneumonia 64.81 10.86 19 210277 19691 34726944
Appendicolith 64.64 10.86 153 210143 8448 34738187
Sleep apnoea syndrome 63.88 10.86 267 210029 20054 34726581
Restrictive pulmonary disease 63.75 10.86 55 210241 1149 34745486
Increased bronchial secretion 63.48 10.86 67 210229 1814 34744821
Sensitivity to weather change 62.28 10.86 62 210234 1564 34745071
Lung diffusion test decreased 60.96 10.86 41 210255 580 34746055
Device malfunction 60.32 10.86 168 210128 10253 34736382
Sleep disorder 60.21 10.86 361 209935 31327 34715308
Product container issue 60.09 10.86 43 210253 676 34745959
Bronchospasm paradoxical 60.01 10.86 20 210276 42 34746593
Disseminated intravascular coagulation 60.01 10.86 28 210268 21788 34724847
Oropharyngeal pain 59.79 10.86 392 209904 35093 34711542
Circumstance or information capable of leading to device use error 59.07 10.86 15 210281 3 34746632
Rhabdomyolysis 58.96 10.86 211 210085 67952 34678683
Illness 58.56 10.86 197 210099 13332 34733303
Rhonchi 58.30 10.86 65 210231 1875 34744760
Heart rate increased 57.52 10.86 476 209820 45867 34700768
Device ineffective 57.39 10.86 17 210279 19 34746616
Multiple allergies 57.12 10.86 80 210216 2923 34743712
Respiratory symptom 57.11 10.86 62 210234 1735 34744900
Cerebral infarction 56.66 10.86 49 210247 27406 34719229
Stomatitis 56.45 10.86 106 210190 42408 34704227
Throat tightness 55.73 10.86 142 210154 8216 34738419
Hepatotoxicity 55.46 10.86 30 210266 21455 34725180
Overdose 55.36 10.86 321 209975 90738 34655897
Obesity 55.28 10.86 187 210109 12691 34733944
Inhalation therapy 54.43 10.86 16 210280 17 34746618
Respiratory distress 54.14 10.86 384 209912 35281 34711354
Bronchiolitis 53.68 10.86 80 210216 3096 34743539
Drug reaction with eosinophilia and systemic symptoms 53.58 10.86 72 210224 32940 34713695
Synovitis 53.28 10.86 10 210286 14056 34732579
Pulmonary mass 53.21 10.86 184 210112 12628 34734007
Wrong technique in device usage process 53.07 10.86 55 210241 1457 34745178
Blood lactate dehydrogenase increased 52.54 10.86 37 210259 22953 34723682
Respiratory tract infection 52.13 10.86 246 210050 19466 34727169
C-reactive protein increased 51.91 10.86 160 210136 53938 34692697
Cerebral haemorrhage 51.04 10.86 82 210214 34855 34711780
Congenital hiatus hernia 49.72 10.86 41 210255 803 34745832
Lower respiratory tract congestion 49.25 10.86 48 210248 1179 34745456
Sputum abnormal 49.17 10.86 33 210263 465 34746170
Fractional exhaled nitric oxide increased 48.52 10.86 45 210251 1037 34745598
Product complaint 47.81 10.86 108 210188 5782 34740853
Rhinitis allergic 47.55 10.86 74 210222 2976 34743659
Peak expiratory flow rate decreased 47.53 10.86 21 210275 118 34746517
Palmar-plantar erythrodysaesthesia syndrome 47.06 10.86 21 210275 16774 34729861
Rhinitis 46.83 10.86 112 210184 6226 34740409
Hypoventilation 46.63 10.86 78 210218 3336 34743299
Blood cholesterol 46.36 10.86 24 210272 201 34746434
Discomfort 46.24 10.86 231 210065 18707 34727928
Cytokine release syndrome 45.80 10.86 42 210254 22835 34723800
Atelectasis 44.54 10.86 218 210078 17509 34729126
Tubulointerstitial nephritis 44.02 10.86 37 210259 20987 34725648
Dyspnoea at rest 43.91 10.86 81 210215 3747 34742888
Eosinophilia 43.76 10.86 289 210007 25933 34720702
Rales 43.74 10.86 145 210151 9738 34736897
Right ventricular hypertrophy 43.72 10.86 50 210246 1484 34745151
Cardiac failure 43.34 10.86 346 209950 90902 34655733
Serotonin syndrome 43.08 10.86 34 210262 19899 34726736
Neoplasm progression 41.83 10.86 47 210249 23253 34723382
Total lung capacity decreased 41.51 10.86 39 210257 914 34745721
Respiration abnormal 41.31 10.86 71 210225 3105 34743530
Increased viscosity of bronchial secretion 40.97 10.86 22 210274 200 34746435
Spinal muscular atrophy 40.93 10.86 27 210269 369 34746266
Cardio-respiratory arrest 40.28 10.86 183 210113 55090 34691545
Painful respiration 39.90 10.86 43 210253 1193 34745442
Poisoning 39.80 10.86 12 210284 12214 34734421
Anaphylactic reaction 39.66 10.86 331 209965 31970 34714665
Forced expiratory flow decreased 39.51 10.86 20 210276 159 34746476
Depressed level of consciousness 39.49 10.86 129 210167 42712 34703923
Suicide attempt 39.46 10.86 113 210183 39003 34707632
Airway remodelling 39.45 10.86 22 210274 217 34746418
Thrombotic microangiopathy 39.33 10.86 8 210288 10622 34736013
Drug-induced liver injury 39.06 10.86 71 210225 28761 34717874
Progressive multifocal leukoencephalopathy 39.06 10.86 6 210290 9758 34736877
Cystic fibrosis respiratory infection suppression 38.94 10.86 22 210274 223 34746412
Choking 38.55 10.86 90 210206 4925 34741710
Respiratory failure 38.35 10.86 889 209407 107683 34638952
Neuroleptic malignant syndrome 38.24 10.86 31 210265 17903 34728732
Death 38.20 10.86 1982 208314 396067 34350568
Rheumatoid arthritis 38.18 10.86 111 210185 38127 34708508
Eosinophilic bronchitis 38.02 10.86 21 210275 203 34746432
Posterior reversible encephalopathy syndrome 37.86 10.86 7 210289 9947 34736688
Body temperature decreased 37.69 10.86 167 210129 12867 34733768
Sopor 37.58 10.86 13 210283 12123 34734512
Smoke sensitivity 37.36 10.86 18 210278 127 34746508
Cytopenia 37.10 10.86 15 210281 12708 34733927
Sneezing 36.98 10.86 91 210205 5151 34741484
Acute respiratory failure 36.95 10.86 315 209981 30613 34716022
Hypotension 36.93 10.86 1033 209263 220616 34526019
Throat clearing 36.64 10.86 24 210272 324 34746311
Agranulocytosis 36.62 10.86 54 210242 23767 34722868
Vocal cord dysfunction 36.32 10.86 19 210277 163 34746472
Altered state of consciousness 36.08 10.86 51 210245 22842 34723793
Therapy partial responder 36.07 10.86 7 210289 9609 34737026
Acute myeloid leukaemia 36.03 10.86 34 210262 18236 34728399
Crepitations 35.87 10.86 67 210229 3129 34743506
Drug intolerance 35.65 10.86 211 210085 59359 34687276
Osteonecrosis of jaw 35.62 10.86 33 210263 17856 34728779
Rhinitis perennial 35.52 10.86 23 210273 304 34746331
Hepatic failure 35.39 10.86 99 210197 34432 34712203
Hyperthermia 35.13 10.86 10 210286 10567 34736068
Respiratory tract irritation 35.13 10.86 20 210276 206 34746429
Lung opacity 35.07 10.86 56 210240 2303 34744332
Food allergy 35.02 10.86 44 210252 1444 34745191
Status asthmaticus 35.02 10.86 23 210273 312 34746323
Encephalopathy 34.92 10.86 103 210193 35216 34711419
Metabolic acidosis 34.66 10.86 140 210156 43540 34703095
Upper respiratory fungal infection 34.35 10.86 18 210278 155 34746480
Polyneuropathy 34.00 10.86 24 210272 14872 34731763
Anxiety 33.85 10.86 810 209486 98618 34648017
Superinfection 33.67 10.86 57 210239 2462 34744173
Appendicitis 33.63 10.86 177 210119 14630 34732005
Forced expiratory volume 33.55 10.86 16 210280 110 34746525
C-reactive protein abnormal 33.40 10.86 6 210290 8704 34737931
Pathogen resistance 33.33 10.86 8 210288 9474 34737161
Therapy non-responder 33.29 10.86 122 210174 39024 34707611
Eosinophil count 33.18 10.86 17 210279 139 34746496
Suffocation feeling 33.14 10.86 28 210268 568 34746067
Haemoglobin decreased 33.06 10.86 519 209777 120253 34626382
Lymph node calcification 32.98 10.86 17 210279 141 34746494
FEV1/FVC ratio decreased 32.74 10.86 15 210281 93 34746542
Neurotoxicity 32.69 10.86 36 210260 17974 34728661
Snoring 32.51 10.86 66 210230 3280 34743355
Intentional product use issue 32.14 10.86 219 210077 59597 34687038
Soft tissue mass 32.11 10.86 35 210261 984 34745651
Transplant rejection 32.01 10.86 11 210285 10300 34736335
Perfume sensitivity 31.96 10.86 15 210281 99 34746536
Decreased activity 31.85 10.86 77 210219 4310 34742325
Circumstance or information capable of leading to medication error 31.78 10.86 46 210250 1733 34744902
Nasal disorder 31.78 10.86 48 210248 1880 34744755
Liver disorder 31.36 10.86 98 210198 32899 34713736
Colitis 31.22 10.86 119 210177 37631 34709004
Lung diffusion disorder 31.21 10.86 16 210280 131 34746504
Plantar fasciitis 31.14 10.86 50 210246 2066 34744569
Chest pain 30.83 10.86 989 209307 125773 34620862
Haemophagocytic lymphohistiocytosis 30.82 10.86 20 210276 12953 34733682
Peritonitis 30.50 10.86 32 210264 16333 34730302
Blood immunoglobulin E decreased 30.41 10.86 12 210284 48 34746587
Hyperkalaemia 30.28 10.86 269 210027 69120 34677515
Parathyroid gland enlargement 30.22 10.86 16 210280 141 34746494
Akathisia 30.21 10.86 6 210290 8103 34738532
Hyperbilirubinaemia 30.21 10.86 34 210262 16809 34729826
Tumour lysis syndrome 29.99 10.86 35 210261 17024 34729611
Graft versus host disease 29.95 10.86 13 210283 10556 34736079
Confusional state 29.93 10.86 650 209646 143510 34603125
Viral infection 29.87 10.86 195 210101 17428 34729207
Increased upper airway secretion 29.74 10.86 45 210251 1765 34744870
Blood phosphorus increased 29.59 10.86 108 210188 7613 34739022
Aortic valve stenosis 29.51 10.86 56 210240 2647 34743988
Victim of child abuse 29.49 10.86 32 210264 895 34745740
Dysphonia 29.44 10.86 241 210055 23142 34723493
Pancreatitis 29.40 10.86 127 210169 38764 34707871
Osteoporosis 29.16 10.86 152 210144 12516 34734119
Hypercapnia 29.10 10.86 73 210223 4182 34742453
Nasal inflammation 29.04 10.86 19 210277 256 34746379
Proteinuria 28.91 10.86 42 210254 18600 34728035
Hepatitis 28.82 10.86 63 210233 23841 34722794
Haematochezia 28.82 10.86 163 210133 46371 34700264
Lower respiratory tract infection bacterial 28.81 10.86 24 210272 477 34746158
Drug eruption 28.78 10.86 47 210249 19851 34726784
Mycobacterium avium complex infection 28.64 10.86 53 210243 2458 34744177
Breath alcohol test positive 28.51 10.86 8 210288 6 34746629
Pickwickian syndrome 28.45 10.86 12 210284 59 34746576
Prostate cancer 28.45 10.86 132 210164 39517 34707118
Respiratory syncytial virus infection 28.33 10.86 77 210219 4632 34742003
Ear infection 28.02 10.86 129 210167 10102 34736533
Epidural lipomatosis 27.78 10.86 33 210263 1021 34745614
Factitious disorder 27.49 10.86 11 210285 46 34746589
Benign prostatic hyperplasia 27.44 10.86 165 210131 14330 34732305
Chronic kidney disease 27.37 10.86 141 210155 41069 34705566
Hormone receptor positive breast cancer 27.27 10.86 10 210286 31 34746604
Alanine aminotransferase increased 27.21 10.86 333 209963 80482 34666153
Sensation of foreign body 27.16 10.86 55 210241 2728 34743907
Low birth weight baby 27.15 10.86 7 210289 7898 34738737
Product prescribing error 27.12 10.86 233 210063 22694 34723941
Pneumonia lipoid 27.08 10.86 12 210284 68 34746567
Drug ineffective 26.85 10.86 2375 207921 454376 34292259
Hypersensitivity 26.81 10.86 516 209780 60519 34686116
Eye swelling 26.62 10.86 125 210171 9870 34736765
Aspartate aminotransferase increased 26.50 10.86 270 210026 67513 34679122
Product delivery mechanism issue 26.47 10.86 15 210281 153 34746482
Pancreatitis acute 26.44 10.86 84 210212 28057 34718578
Stoma closure 26.38 10.86 18 210278 261 34746374
Tracheal disorder 25.82 10.86 15 210281 161 34746474
Pneumococcal sepsis 25.77 10.86 33 210263 1104 34745531
Mycobacterial infection 25.69 10.86 49 210247 2325 34744310
Atopy 25.61 10.86 17 210279 235 34746400
Herpes zoster 25.59 10.86 113 210183 34286 34712349
Drug ineffective for unapproved indication 25.04 10.86 67 210229 23648 34722987
Shock haemorrhagic 25.00 10.86 19 210277 11335 34735300
Product taste abnormal 24.94 10.86 33 210263 1141 34745494
Wolff-Parkinson-White syndrome 24.81 10.86 16 210280 210 34746425
Eye pruritus 24.79 10.86 100 210196 7389 34739246
Factor V Leiden mutation 24.52 10.86 12 210284 88 34746547
Gamma-glutamyltransferase increased 24.27 10.86 92 210204 29139 34717496
Extrapyramidal disorder 24.21 10.86 25 210271 12855 34733780
Disorientation 24.10 10.86 110 210186 33078 34713557
Metastases to liver 24.05 10.86 28 210268 13635 34733000
Multimorbidity 24.02 10.86 29 210267 913 34745722
Venoocclusive liver disease 23.88 10.86 9 210287 7957 34738678
Cystitis haemorrhagic 23.87 10.86 3 210293 5676 34740959
Mean platelet volume increased 23.68 10.86 22 210274 508 34746127
Haematuria 23.68 10.86 190 210106 49876 34696759
Dehydration 23.63 10.86 598 209698 129371 34617264
Foetal malformation 23.59 10.86 13 210283 125 34746510
Neuropsychiatric symptoms 23.37 10.86 28 210268 874 34745761
Hepatitis B 23.21 10.86 4 210292 5979 34740656
Disease complication 23.14 10.86 51 210245 2685 34743950
Ocular discomfort 23.04 10.86 44 210252 2090 34744545
Toxic epidermal necrolysis 22.97 10.86 61 210235 21585 34725050
Cytomegalovirus viraemia 22.94 10.86 8 210288 7422 34739213
Right atrial enlargement 22.60 10.86 16 210280 247 34746388
Pulmonary congestion 22.53 10.86 151 210145 13614 34733021
Brain natriuretic peptide increased 22.40 10.86 80 210216 5579 34741056
Psoriatic arthropathy 22.40 10.86 54 210242 19744 34726891
Oesophageal polyp 22.37 10.86 10 210286 58 34746577
Epstein-Barr virus infection 22.23 10.86 9 210287 7619 34739016
Seizure 21.98 10.86 472 209824 104385 34642250
Nephropathy toxic 21.94 10.86 26 210270 12562 34734073
Total lung capacity abnormal 21.88 10.86 13 210283 146 34746489
Blood bilirubin increased 21.68 10.86 138 210158 38158 34708477
Acute generalised exanthematous pustulosis 21.43 10.86 7 210289 6769 34739866
Inspiratory capacity abnormal 21.38 10.86 12 210284 120 34746515
Chronic respiratory failure 21.35 10.86 34 210262 1395 34745240
Joint injury 21.07 10.86 110 210186 9063 34737572
Hypercalcaemia 21.03 10.86 38 210258 15430 34731205
Psychotic disorder 20.92 10.86 76 210220 24376 34722259
Musculoskeletal stiffness 20.79 10.86 180 210116 46500 34700135
Foetal exposure during pregnancy 20.71 10.86 139 210157 37962 34708673
Jaundice 20.66 10.86 110 210186 31772 34714863
Brain oedema 20.60 10.86 32 210264 13789 34732846
Hypoacusis 20.52 10.86 168 210128 16133 34730502
Blood alkaline phosphatase increased 20.51 10.86 107 210189 31068 34715567
Swelling face 20.49 10.86 221 210075 22884 34723751
Nasal discharge discolouration 20.49 10.86 16 210280 289 34746346
Blood creatine phosphokinase increased 20.41 10.86 172 210124 44685 34701950
Tachypnoea 20.40 10.86 184 210112 18168 34728467
Motor neurone disease 20.33 10.86 20 210276 497 34746138
Bradycardia 20.32 10.86 325 209971 75093 34671542
Forced expiratory volume abnormal 20.08 10.86 8 210288 33 34746602
Kidney transplant rejection 20.04 10.86 10 210286 7487 34739148
Paranasal sinus discomfort 20.03 10.86 25 210271 815 34745820
Restlessness 20.01 10.86 82 210214 25400 34721235
Oesophageal perforation 19.97 10.86 30 210266 1169 34745466
Multiple organ dysfunction syndrome 19.95 10.86 332 209964 76234 34670401
Urinary retention 19.91 10.86 132 210164 36156 34710479
Polyp 19.88 10.86 60 210236 3832 34742803
Cerebral artery thrombosis 19.86 10.86 24 210272 756 34745879
Abnormal clotting factor 19.81 10.86 10 210286 79 34746556
Fall 19.79 10.86 1008 209288 201877 34544758
Nasal oedema 19.79 10.86 17 210279 353 34746282
Skin discomfort 19.74 10.86 12 210284 141 34746494
Myelodysplastic syndrome 19.73 10.86 55 210241 19153 34727482
Hepatocellular injury 19.70 10.86 68 210228 22143 34724492
Cor pulmonale acute 19.58 10.86 15 210281 263 34746372
Lymphoma 19.57 10.86 28 210268 12479 34734156
Haemophilus infection 19.56 10.86 30 210266 1191 34745444
Sleep terror 19.37 10.86 43 210253 2275 34744360
Vascular shunt 19.36 10.86 8 210288 37 34746598
Panic reaction 19.22 10.86 33 210263 1442 34745193
Renal tubular necrosis 19.17 10.86 41 210255 15639 34730996
Cholestasis 19.16 10.86 90 210206 26858 34719777
Encephalitis toxic 19.11 10.86 15 210281 273 34746362
Eczema 19.07 10.86 182 210114 18254 34728381
Acute graft versus host disease in skin 19.06 10.86 4 210292 5197 34741438
Mucormycosis 19.04 10.86 6 210290 5936 34740699
Febrile bone marrow aplasia 19.04 10.86 13 210283 8196 34738439
Attention-seeking behaviour 19.02 10.86 8 210288 39 34746596
Product administered to patient of inappropriate age 18.99 10.86 53 210243 3238 34743397
Rhinovirus infection 18.96 10.86 63 210233 4236 34742399
Second primary malignancy 18.95 10.86 12 210284 7874 34738761
Diastolic dysfunction 18.93 10.86 81 210215 6146 34740489
Suspected suicide 18.80 10.86 3 210293 4745 34741890
Nasal turbinate abnormality 18.79 10.86 7 210289 23 34746612
Poisoning deliberate 18.76 10.86 12 210284 7832 34738803
Brain injury 18.75 10.86 80 210216 6062 34740573
Blood pressure fluctuation 18.75 10.86 83 210213 25166 34721469
Blood pressure systolic increased 18.75 10.86 216 210080 22736 34723899
Device related infection 18.73 10.86 48 210248 17189 34729446
Fungal disease carrier 18.70 10.86 15 210281 282 34746353
Dry skin 18.66 10.86 278 210018 31009 34715626
Sinus operation 18.66 10.86 22 210274 675 34745960
Anger 18.64 10.86 129 210167 11755 34734880
Anuria 18.58 10.86 21 210275 10364 34736271
Rash maculo-papular 18.52 10.86 98 210198 28353 34718282
Asthenia 18.46 10.86 1249 209047 244002 34502633
Sinus disorder 18.42 10.86 88 210208 6997 34739638
Swollen tongue 18.10 10.86 150 210146 14455 34732180
Enthesopathy 18.08 10.86 3 210293 4610 34742025
Urinary tract infection 18.05 10.86 377 209919 83704 34662931
BK virus infection 18.02 10.86 6 210290 5732 34740903
Ataxia 17.98 10.86 35 210261 13818 34732817
Bladder cancer 17.94 10.86 45 210251 16233 34730402
Nightmare 17.94 10.86 148 210148 14243 34732392
Carbon dioxide increased 17.94 10.86 27 210269 1054 34745581
Hepatitis cholestatic 17.88 10.86 13 210283 7934 34738701
Tenosynovitis 17.85 10.86 3 210293 4567 34742068
Social avoidant behaviour 17.82 10.86 50 210246 3064 34743571
Subdural haematoma 17.79 10.86 63 210233 20358 34726277
Squamous cell carcinoma 17.65 10.86 26 210270 11449 34735186
Shock 17.64 10.86 80 210216 24099 34722536
Mood swings 17.64 10.86 94 210202 7807 34738828
Metastases to lung 17.62 10.86 18 210278 9302 34737333
Cystic fibrosis related diabetes 17.59 10.86 12 210284 174 34746461
Sepsis 17.51 10.86 821 209475 165740 34580895
Hypopnoea 17.51 10.86 41 210255 2248 34744387
Animal scratch 17.46 10.86 13 210283 218 34746417
Viral upper respiratory tract infection 17.42 10.86 46 210250 2720 34743915
Blood urea increased 17.40 10.86 109 210187 30255 34716380
Infective exacerbation of chronic obstructive airways disease 17.38 10.86 36 210260 1815 34744820
Lymphopenia 17.36 10.86 46 210250 16289 34730346
Sputum purulent 17.33 10.86 18 210278 478 34746157
Expiratory reserve volume decreased 17.28 10.86 8 210288 51 34746584
Oliguria 17.23 10.86 15 210281 8365 34738270
Accessory spleen 17.21 10.86 11 210285 142 34746493
Lymphadenectomy 17.17 10.86 16 210280 371 34746264
Sarcopenia 17.13 10.86 17 210279 427 34746208
Scoliosis 17.13 10.86 46 210250 2747 34743888
Ileus 17.13 10.86 47 210249 16452 34730183
Eye disorder 17.11 10.86 107 210189 9421 34737214
Myocardial infarction 17.02 10.86 577 209719 120508 34626127
Infusion related reaction 16.97 10.86 221 210075 52836 34693799
Bradyphrenia 16.96 10.86 4 210292 4794 34741841
Sinus polyp 16.80 10.86 12 210284 188 34746447
Pulmonary toxicity 16.73 10.86 8 210288 6139 34740496
Social problem 16.66 10.86 24 210272 900 34745735
Escherichia infection 16.66 10.86 15 210281 8230 34738405
Cystic fibrosis lung 16.66 10.86 8 210288 56 34746579
Pulmonary eosinophilia 16.59 10.86 13 210283 236 34746399
Chronic respiratory disease 16.56 10.86 9 210287 84 34746551
Sensory integrative dysfunction 16.50 10.86 7 210289 35 34746600
Bed bug infestation 16.48 10.86 4 210292 0 34746635
Enterococcal infection 16.46 10.86 19 210277 9287 34737348
Haemorrhage 16.42 10.86 214 210082 51156 34695479
Wrong technique in product usage process 16.40 10.86 306 209990 35680 34710955
Squamous cell carcinoma of skin 16.40 10.86 25 210271 10856 34735779
Pharyngeal oedema 16.38 10.86 76 210220 5971 34740664
Acute myocardial infarction 16.36 10.86 226 210070 53493 34693142
Multiple sclerosis relapse 16.34 10.86 34 210262 13099 34733536
Hypertriglyceridaemia 16.33 10.86 16 210280 8432 34738203
Exposure to fungus 16.26 10.86 5 210291 7 34746628
Gait disturbance 16.21 10.86 389 209907 84751 34661884
Mouth swelling 16.16 10.86 35 210261 1821 34744814
Blood urine 16.10 10.86 18 210278 521 34746114
Brain scan abnormal 16.08 10.86 23 210273 857 34745778
Myoclonus 16.00 10.86 41 210255 14684 34731951
Syringe issue 16.00 10.86 7 210289 5657 34740978
Mycobacterium test positive 15.99 10.86 16 210280 406 34746229
Ventricular hyperkinesia 15.98 10.86 12 210284 204 34746431
Pancreatic carcinoma 15.93 10.86 18 210278 8883 34737752
Decreased gait velocity 15.86 10.86 11 210285 164 34746471
Joint swelling 15.82 10.86 259 210037 59631 34687004
Myoglobin blood increased 15.81 10.86 47 210249 2976 34743659
Bronchopulmonary aspergillosis 15.79 10.86 41 210255 14618 34732017
Hepatic steatosis 15.76 10.86 57 210239 18305 34728330
Inguinal hernia repair 15.74 10.86 14 210282 305 34746330
Resuscitation 15.74 10.86 30 210266 1423 34745212
Toxic encephalopathy 15.62 10.86 6 210290 5243 34741392
Cockroach allergy 15.61 10.86 7 210289 41 34746594
Hypoalbuminaemia 15.59 10.86 31 210265 12143 34734492
Multiple-drug resistance 15.57 10.86 6 210290 5233 34741402
Klebsiella infection 15.54 10.86 17 210279 8514 34738121
Malignant melanoma in situ 15.52 10.86 33 210263 1695 34744940
Product cleaning inadequate 15.50 10.86 5 210291 9 34746626
Subarachnoid haemorrhage 15.48 10.86 33 210263 12602 34734033
Pleural thickening 15.34 10.86 15 210281 370 34746265
Abnormal behaviour 15.34 10.86 223 210073 24746 34721889
Aspirin-exacerbated respiratory disease 15.27 10.86 15 210281 372 34746263
Urticaria 15.23 10.86 487 209809 61890 34684745
Accidental exposure to product 15.22 10.86 34 210262 12768 34733867
Rubber sensitivity 15.21 10.86 12 210284 220 34746415
Croup infectious 15.21 10.86 15 210281 374 34746261
Flour sensitivity 15.20 10.86 6 210290 24 34746611
Sedation 15.03 10.86 70 210226 20936 34725699
Drug level increased 15.01 10.86 75 210221 22021 34724614
Drug level decreased 15.01 10.86 15 210281 7831 34738804
Encephalitis 15.00 10.86 13 210283 7264 34739371
Iron deficiency 14.85 10.86 68 210228 5313 34741322
Lip swelling 14.82 10.86 155 210141 15925 34730710
Stridor 14.81 10.86 41 210255 2493 34744142
Immune thrombocytopenia 14.81 10.86 20 210276 9132 34737503
Renal injury 14.78 10.86 28 210268 11167 34735468
Intervertebral disc degeneration 14.77 10.86 77 210219 6340 34740295
Deep vein thrombosis 14.76 10.86 290 210006 64958 34681677
Cardiac arrest 14.75 10.86 453 209843 95706 34650929
Dyslipidaemia 14.69 10.86 14 210282 7474 34739161
Hyperuricaemia 14.68 10.86 16 210280 8027 34738608
Nervous system disorder 14.67 10.86 42 210254 14501 34732134
Nausea 14.66 10.86 1806 208490 338102 34408533
Diaphragmatic disorder 14.65 10.86 27 210269 1248 34745387
Exercise tolerance decreased 14.57 10.86 66 210230 5132 34741503
Alanine aminotransferase abnormal 14.55 10.86 5 210291 4683 34741952
Hepatic cytolysis 14.53 10.86 42 210254 14454 34732181
Diastolic hypotension 14.46 10.86 7 210289 50 34746585
Graft versus host disease in skin 14.42 10.86 3 210293 3922 34742713
Coagulation factor deficiency 14.37 10.86 10 210286 150 34746485
Basal cell carcinoma 14.36 10.86 65 210231 19593 34727042
Intentional device misuse 14.35 10.86 11 210285 193 34746442
Gastrointestinal haemorrhage 14.27 10.86 414 209882 88063 34658572
Hypertransaminasaemia 14.22 10.86 8 210288 5598 34741037
Diffuse large B-cell lymphoma 14.20 10.86 14 210282 7356 34739279
Ejection fraction decreased 14.20 10.86 63 210233 19091 34727544
Hepatic fibrosis 14.15 10.86 5 210291 4602 34742033
Dyskinesia 14.15 10.86 78 210218 22335 34724300
Percussion test abnormal 14.15 10.86 6 210290 30 34746605
Small airways disease 14.15 10.86 6 210290 30 34746605
Decreased appetite 14.12 10.86 838 209458 165554 34581081
Allergy to chemicals 14.09 10.86 8 210288 82 34746553
Gastroenteritis viral 14.07 10.86 82 210214 7042 34739593
Alveolar bone resorption 14.01 10.86 5 210291 14 34746621
Aplastic anaemia 14.00 10.86 23 210273 9693 34736942
Hyperglycaemia 13.93 10.86 161 210135 39319 34707316
Aphasia 13.91 10.86 74 210222 21380 34725255
Use of accessory respiratory muscles 13.89 10.86 15 210281 417 34746218
Upper respiratory tract congestion 13.87 10.86 21 210275 824 34745811
Drug use disorder 13.85 10.86 4 210292 4187 34742448
Aplasia pure red cell 13.84 10.86 10 210286 6122 34740513
Bronchitis viral 13.78 10.86 12 210284 254 34746381
Infective exacerbation of bronchiectasis 13.64 10.86 15 210281 426 34746209
Respiratory syncytial virus bronchiolitis 13.61 10.86 15 210281 427 34746208
Antineutrophil cytoplasmic antibody positive 13.61 10.86 20 210276 764 34745871
Endotracheal intubation 13.59 10.86 45 210251 3020 34743615
Hepatic enzyme increased 13.54 10.86 160 210136 38920 34707715
Hyperthyroidism 13.45 10.86 27 210269 10539 34736096
Myocarditis 13.45 10.86 40 210256 13642 34732993
Foreign body aspiration 13.41 10.86 10 210286 168 34746467
Tracheostomy malfunction 13.39 10.86 7 210289 60 34746575
Skin toxicity 13.37 10.86 6 210290 4778 34741857
Miosis 13.35 10.86 23 210273 9512 34737123
Ocular hyperaemia 13.34 10.86 116 210180 11336 34735299
Renal disorder 13.33 10.86 94 210202 25386 34721249
Lymphocyte count abnormal 13.30 10.86 25 210271 1173 34745462
Visual acuity reduced 13.29 10.86 51 210245 16098 34730537
Dermatitis exfoliative generalised 13.28 10.86 3 210293 3704 34742931
Anal fistula 13.27 10.86 8 210288 5391 34741244
Adjustment disorder 13.26 10.86 25 210271 1176 34745459
Frustration tolerance decreased 13.24 10.86 40 210256 2556 34744079
Lacrimal disorder 13.22 10.86 13 210283 323 34746312
Graft versus host disease in gastrointestinal tract 13.16 10.86 3 210293 3680 34742955
Influenza B virus test positive 13.16 10.86 8 210288 94 34746541
Stiff person syndrome 13.16 10.86 8 210288 94 34746541
Cortisol decreased 13.12 10.86 24 210272 1103 34745532
Sputum retention 13.07 10.86 15 210281 447 34746188
Aptyalism 13.06 10.86 14 210282 386 34746249
Cholecystitis 13.02 10.86 28 210268 10660 34735975
Prescribed underdose 13.01 10.86 21 210275 8912 34737723
Oxygen therapy 12.95 10.86 21 210275 875 34745760
Prolonged expiration 12.94 10.86 11 210285 225 34746410
Eye infection 12.93 10.86 50 210246 3623 34743012
Toxic skin eruption 12.92 10.86 31 210265 11354 34735281
Lung hernia 12.91 10.86 7 210289 65 34746570
Humidity intolerance 12.87 10.86 5 210291 19 34746616
Blood immunoglobulin E abnormal 12.87 10.86 5 210291 19 34746616
Mucosal hypertrophy 12.86 10.86 6 210290 39 34746596
Emotional disorder of childhood 12.86 10.86 6 210290 39 34746596
Blebitis 12.85 10.86 4 210292 6 34746629
Gastric cancer 12.80 10.86 12 210284 6457 34740178
Product distribution issue 12.78 10.86 18 210278 661 34745974
End stage renal disease 12.75 10.86 21 210275 8840 34737795
Asthma exercise induced 12.74 10.86 8 210288 100 34746535
Tendon calcification 12.64 10.86 7 210289 68 34746567
Adenovirus infection 12.63 10.86 8 210288 5249 34741386
Skin ulcer 12.60 10.86 80 210216 22136 34724499
Metastases to bone 12.50 10.86 34 210262 11936 34734699
Malpositioned teeth 12.48 10.86 5 210291 21 34746614
Personal relationship issue 12.47 10.86 12 210284 290 34746345
Red cell distribution width increased 12.43 10.86 71 210225 6052 34740583
Electrocardiogram QT shortened 12.39 10.86 9 210287 145 34746490
Coagulation factor V level abnormal 12.38 10.86 6 210290 43 34746592
Influenza immunisation 12.36 10.86 3 210293 0 34746635
Occupational asthma 12.36 10.86 3 210293 0 34746635
Emergency care examination 12.36 10.86 3 210293 0 34746635
Infusion site injury 12.36 10.86 3 210293 0 34746635
Physical product label issue 12.36 10.86 3 210293 0 34746635
Panic attack 12.30 10.86 98 210198 9334 34737301
Nasal septum deviation 12.29 10.86 23 210273 1076 34745559
Nasal discomfort 12.28 10.86 29 210267 1599 34745036
Endophthalmitis 12.25 10.86 3 210293 3505 34743130
Dementia 12.25 10.86 42 210254 13706 34732929
Hemiparesis 12.24 10.86 51 210245 15727 34730908
Angina pectoris 12.22 10.86 125 210171 31238 34715397
Somnolence 12.21 10.86 545 209751 110571 34636064
Nervous system neoplasm 12.18 10.86 9 210287 149 34746486
Tracheitis 12.09 10.86 18 210278 696 34745939
Blood pressure increased 12.09 10.86 647 209649 87455 34659180
Substance abuse 12.06 10.86 17 210279 7624 34739011
Neurodevelopmental disorder 12.04 10.86 14 210282 423 34746212
Amnesia 12.02 10.86 102 210194 26461 34720174
Colon cancer 11.88 10.86 21 210275 8600 34738035
Coronary artery stenosis 11.88 10.86 25 210271 9591 34737044
Hypochromasia 11.85 10.86 12 210284 309 34746326
Back injury 11.85 10.86 52 210244 3989 34742646
Dysarthria 11.82 10.86 143 210153 34639 34711996
Haemolysis 11.81 10.86 19 210277 8075 34738560
Tic 11.73 10.86 33 210263 2025 34744610
Anal abscess 11.68 10.86 13 210283 6460 34740175
Cardiogenic shock 11.67 10.86 225 210071 26393 34720242
Central nervous system lesion 11.64 10.86 13 210283 6450 34740185
Pseudomonas bronchitis 11.63 10.86 5 210291 26 34746609
Bronchial irritation 11.63 10.86 5 210291 26 34746609
Chest injury 11.63 10.86 28 210268 1563 34745072
Status epilepticus 11.61 10.86 38 210258 12576 34734059
Eosinophilic oesophagitis 11.61 10.86 12 210284 317 34746318
Pain 11.55 10.86 1067 209229 203608 34543027
Total lung capacity increased 11.53 10.86 4 210292 10 34746625
Infusion site pruritus 11.50 10.86 19 210277 804 34745831
Bronchopulmonary dysplasia 11.48 10.86 16 210280 582 34746053
Lymphocyte count 11.46 10.86 7 210289 83 34746552
Hypertensive crisis 11.45 10.86 22 210274 8729 34737906
Melaena 11.45 10.86 147 210149 35233 34711402
Dizziness exertional 11.43 10.86 10 210286 213 34746422
General physical health deterioration 11.42 10.86 643 209653 127626 34619009
Skin necrosis 11.41 10.86 11 210285 5842 34740793
Ischaemic cerebral infarction 11.41 10.86 24 210272 1223 34745412
Limb injury 11.40 10.86 114 210182 11575 34735060
B-cell lymphoma 11.39 10.86 6 210290 4357 34742278
Product use in unapproved indication 11.39 10.86 584 209712 116915 34629720
Bone erosion 11.28 10.86 5 210291 4010 34742625
Food refusal 11.28 10.86 10 210286 217 34746418
Pigment dispersion syndrome 11.26 10.86 4 210292 11 34746624
Diabetic ketoacidosis 11.25 10.86 63 210233 17969 34728666
Transposition of the great vessels 11.25 10.86 14 210282 455 34746180
Pharyngeal paraesthesia 11.21 10.86 17 210279 668 34745967
Central nervous system mass 11.19 10.86 9 210287 170 34746465
Post procedural swelling 11.19 10.86 9 210287 170 34746465
Paraneoplastic rash 11.18 10.86 7 210289 87 34746548
Psychomotor retardation 11.15 10.86 4 210292 3646 34742989
Infusion site swelling 11.14 10.86 37 210259 2487 34744148
Withdrawal syndrome 11.13 10.86 38 210258 12417 34734218
Erythema multiforme 11.10 10.86 22 210274 8627 34738008
Hydronephrosis 11.10 10.86 29 210267 10317 34736318
Complications of transplanted kidney 11.09 10.86 7 210289 4602 34742033
Hepatic cirrhosis 11.07 10.86 60 210236 17254 34729381
Wall motion score index abnormal 11.05 10.86 9 210287 173 34746462
Delirium 11.05 10.86 192 210104 43799 34702836
Muscular weakness 11.03 10.86 344 209952 72553 34674082
Cerebrovascular accident 11.03 10.86 408 209888 84403 34662232
Neuritis 11.01 10.86 20 210276 914 34745721
Adrenal cortex necrosis 11.01 10.86 4 210292 12 34746623
Acute coronary syndrome 11.00 10.86 43 210253 13502 34733133
Lacrimation increased 10.99 10.86 88 210208 8394 34738241
Insurance issue 10.95 10.86 32 210264 2007 34744628
Bone deformity 10.95 10.86 6 210290 57 34746578
FEV1/FVC ratio abnormal 10.91 10.86 5 210291 31 34746604
Hernia pain 10.91 10.86 11 210285 282 34746353

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 6988.22 10.04 6250 505795 128845 79103498
Wheezing 4600.04 10.04 4648 507397 112016 79120327
Dyspnoea 3251.24 10.04 12433 499612 844592 78387751
Obstructive airways disorder 2511.88 10.04 1877 510168 29582 79202761
Cough 2097.23 10.04 6124 505921 360665 78871678
Full blood count abnormal 1972.93 10.04 1814 510231 38660 79193683
Productive cough 1679.07 10.04 2432 509613 85899 79146444
Sleep disorder due to a general medical condition 1585.74 10.04 1043 511002 13234 79219109
Chronic obstructive pulmonary disease 1481.51 10.04 2253 509792 83166 79149177
Poor quality device used 1472.65 10.04 554 511491 1731 79230612
Forced expiratory volume decreased 1339.92 10.04 754 511291 7060 79225283
Product quality issue 1161.12 10.04 1255 510790 32685 79199658
Completed suicide 1158.77 10.04 117 511928 245650 78986693
Sputum discoloured 1142.86 10.04 1017 511028 20726 79211617
Chest discomfort 1122.98 10.04 2633 509412 135411 79096932
Infective pulmonary exacerbation of cystic fibrosis 1113.96 10.04 806 511239 12045 79220298
Off label use 682.93 10.04 3254 508791 903961 78328382
Pneumonia 669.84 10.04 6823 505222 653423 78578920
Synovitis 648.48 10.04 97 511948 150637 79081706
Bronchitis 609.56 10.04 2036 510009 128608 79103735
Toxicity to various agents 588.59 10.04 1134 510911 420406 78811937
Therapeutic product effect incomplete 583.33 10.04 2118 509927 139527 79092816
Nasal congestion 543.09 10.04 1386 510659 75166 79157177
Middle insomnia 514.47 10.04 574 511471 15495 79216848
Pemphigus 508.97 10.04 33 512012 99549 79132794
Dyspnoea exertional 506.11 10.04 1465 510580 85608 79146735
Hand deformity 504.02 10.04 44 512001 103875 79128468
Loss of personal independence in daily activities 494.80 10.04 1617 510428 100963 79131380
Nasal polyps 494.75 10.04 396 511649 6931 79225412
Drug abuse 484.16 10.04 219 511826 162472 79069871
Treatment failure 465.96 10.04 257 511788 170229 79062114
Bronchiectasis 465.78 10.04 644 511401 21742 79210601
Neutropenia 463.57 10.04 706 511339 287004 78945339
Respiratory disorder 435.68 10.04 919 511126 43937 79188406
Blood immunoglobulin E increased 434.04 10.04 335 511710 5547 79226796
Anti-cyclic citrullinated peptide antibody positive 423.58 10.04 28 512017 83115 79149228
Pulmonary function test decreased 416.80 10.04 365 511680 7272 79225071
Lower respiratory tract infection 394.04 10.04 1760 510285 127460 79104883
Febrile neutropenia 392.46 10.04 546 511499 230453 79001890
Systemic lupus erythematosus 386.37 10.04 147 511898 121002 79111341
Arthropathy 378.95 10.04 347 511698 176764 79055579
Drug intolerance 376.58 10.04 701 511344 263418 78968925
Cystic fibrosis 372.39 10.04 259 511786 3621 79228722
Eosinophil count increased 358.75 10.04 494 511551 16611 79215732
Drug interaction 358.08 10.04 1412 510633 413771 78818572
Breath sounds abnormal 357.07 10.04 476 511569 15508 79216835
Bronchospasm 354.29 10.04 600 511445 24259 79208084
Glossodynia 347.27 10.04 115 511930 103222 79129121
Thrombocytopenia 345.59 10.04 742 511303 264517 78967826
Product dose omission issue 343.41 10.04 2741 509304 244796 78987547
Gastrooesophageal reflux disease 336.15 10.04 1444 510601 102802 79129541
Drug ineffective 328.30 10.04 4930 507115 1075983 78156360
Pericarditis 320.06 10.04 134 511911 104102 79128241
Sleep apnoea syndrome 312.93 10.04 711 511334 35767 79196576
Therapeutic product effect decreased 308.70 10.04 358 511687 163505 79068838
Influenza 305.37 10.04 1640 510405 127966 79104377
Pancytopenia 284.20 10.04 389 511656 165356 79066987
Alopecia 283.50 10.04 669 511376 230686 79001657
Upper-airway cough syndrome 281.04 10.04 361 511684 11332 79221011
Infusion related reaction 277.97 10.04 671 511374 229566 79002777
Helicobacter infection 277.42 10.04 55 511990 69649 79162694
Anaemia 269.23 10.04 1713 510332 443302 78789041
Rhinitis allergic 264.34 10.04 359 511686 11910 79220433
Upper respiratory tract infection 262.39 10.04 1221 510824 89947 79142396
Intentional overdose 257.31 10.04 183 511862 105777 79126566
Blood test abnormal 257.08 10.04 431 511614 17279 79215064
Bronchopulmonary aspergillosis allergic 256.21 10.04 188 511857 2873 79229470
Bronchial secretion retention 250.18 10.04 209 511836 3895 79228448
Pulmonary function test abnormal 248.41 10.04 209 511836 3935 79228408
Contraindicated product administered 248.33 10.04 392 511653 157146 79075197
Secretion discharge 247.21 10.04 387 511658 14635 79217708
Sinusitis 243.31 10.04 2113 509932 193388 79038955
Device delivery system issue 241.67 10.04 110 511935 621 79231722
Reversible airways obstruction 236.80 10.04 157 511888 2019 79230324
Duodenal ulcer perforation 236.33 10.04 66 511979 66145 79166198
Platelet count decreased 232.83 10.04 570 511475 194094 79038249
Malignant neoplasm progression 231.27 10.04 321 511724 135669 79096674
Hepatic function abnormal 229.27 10.04 91 511954 73016 79159327
Heart rate increased 224.93 10.04 1436 510609 119288 79113055
Seasonal allergy 224.59 10.04 389 511656 16017 79216326
Rhinorrhoea 224.19 10.04 1026 511019 75048 79157295
Impaired quality of life 223.50 10.04 361 511684 14025 79218318
Oropharyngeal pain 220.83 10.04 1328 510717 108025 79124318
Hepatic enzyme increased 219.73 10.04 533 511512 182077 79050266
Rales 214.52 10.04 427 511618 19574 79212769
Wound 214.29 10.04 258 511787 115921 79116422
Musculoskeletal stiffness 208.06 10.04 514 511531 174494 79057849
Emphysema 200.69 10.04 369 511676 15931 79216412
White blood cell count decreased 197.54 10.04 588 511457 187700 79044643
Stomatitis 197.30 10.04 403 511642 146354 79085989
Leukopenia 197.13 10.04 276 511769 116237 79116106
Haemoptysis 197.12 10.04 797 511248 55202 79177141
Dust allergy 194.74 10.04 122 511923 1414 79230929
Bronchial wall thickening 193.96 10.04 150 511895 2491 79229852
Respiratory tract congestion 193.93 10.04 409 511636 19545 79212798
Forced vital capacity decreased 192.69 10.04 127 511918 1616 79230727
Respiratory tract infection 191.76 10.04 718 511327 47971 79184372
Illness 190.83 10.04 695 511350 45816 79186527
Eosinophilic granulomatosis with polyangiitis 189.91 10.04 170 511875 3490 79228853
Food allergy 189.55 10.04 287 511758 10537 79221806
Sensitivity to weather change 188.02 10.04 245 511800 7802 79224541
Myelosuppression 187.60 10.04 20 512025 40276 79192067
Asthmatic crisis 185.75 10.04 131 511914 1875 79230468
Asthma-chronic obstructive pulmonary disease overlap syndrome 175.88 10.04 154 511891 3067 79229276
Lung hyperinflation 175.85 10.04 123 511922 1736 79230607
Dysphonia 175.02 10.04 777 511268 56095 79176248
Sputum increased 174.45 10.04 180 511865 4433 79227910
Oxygen saturation decreased 174.39 10.04 1421 510624 127626 79104717
Ear pain 173.79 10.04 535 511510 32334 79200009
Anxiety 173.45 10.04 2394 509651 246118 78986225
Coma 172.70 10.04 236 511809 100413 79131930
Dermatitis atopic 172.37 10.04 264 511781 9792 79222551
Impaired healing 168.83 10.04 188 511857 87467 79144876
Sedation complication 167.42 10.04 334 511711 15335 79217008
Muscle injury 166.74 10.04 52 511993 48509 79183834
Rheumatoid arthritis 165.13 10.04 732 511313 207738 79024605
Bronchial obstruction 164.68 10.04 139 511906 2629 79229714
Respiratory rate increased 164.56 10.04 402 511643 21198 79211145
Polycystic ovaries 160.43 10.04 157 511888 3622 79228721
Peak expiratory flow rate decreased 156.69 10.04 80 511965 603 79231740
Bone marrow failure 156.38 10.04 66 511979 51041 79181302
Malaise 154.81 10.04 4179 507866 485690 78746653
Rheumatoid factor positive 153.79 10.04 97 511948 59742 79172601
C-reactive protein increased 153.29 10.04 379 511666 128648 79103695
Disease progression 152.96 10.04 636 511409 183726 79048617
Cytomegalovirus infection 149.43 10.04 44 512001 42600 79189743
Renal impairment 149.23 10.04 516 511529 157267 79075076
Respiration abnormal 148.61 10.04 215 511830 7573 79224770
Bronchial disorder 148.10 10.04 125 511920 2364 79229979
Intentional product use issue 146.89 10.04 493 511552 151619 79080724
Creatinine renal clearance decreased 145.14 10.04 354 511691 18648 79213695
Vital capacity decreased 144.07 10.04 108 511937 1708 79230635
Mucosal inflammation 143.48 10.04 164 511881 75416 79156927
Acute kidney injury 143.00 10.04 2410 509635 516994 78715349
Joint swelling 142.89 10.04 1176 510869 287470 78944873
Urticaria 141.13 10.04 1813 510232 183388 79048955
Respiratory symptom 139.57 10.04 163 511882 4628 79227715
Restrictive pulmonary disease 139.55 10.04 123 511922 2472 79229871
Nasal obstruction 137.74 10.04 113 511932 2051 79230292
Abdominal discomfort 136.02 10.04 996 511049 249731 78982612
Hypoventilation 135.76 10.04 198 511847 7026 79225317
Eosinophil count abnormal 135.65 10.04 75 511970 676 79231667
Sinus disorder 135.31 10.04 383 511662 22081 79210262
Chest pain 132.80 10.04 2548 509497 279756 78952587
Allergy to animal 130.99 10.04 93 511952 1346 79230997
Bronchospasm paradoxical 130.93 10.04 47 511998 123 79232220
Sleep disorder due to general medical condition, insomnia type 130.48 10.04 58 511987 43498 79188845
Sopor 127.32 10.04 28 512017 32982 79199361
Mite allergy 127.25 10.04 86 511959 1144 79231199
Liver injury 126.95 10.04 106 511939 56508 79175835
Hospitalisation 126.91 10.04 1037 511008 93199 79139144
Hypoxia 126.30 10.04 1112 510933 102131 79130212
Overdose 125.53 10.04 682 511363 183524 79048819
Drug resistance 125.22 10.04 57 511988 42156 79190187
Pulmonary mass 124.33 10.04 440 511605 28594 79203749
Throat clearing 123.53 10.04 116 511929 2538 79229805
Folliculitis 122.58 10.04 105 511940 55275 79177068
Cardio-respiratory arrest 122.52 10.04 327 511718 108183 79124160
Respiratory distress 121.26 10.04 714 511331 57625 79174718
Headache 120.87 10.04 5240 506805 648532 78583811
Conjunctivitis allergic 120.49 10.04 95 511950 1625 79230718
Drug reaction with eosinophilia and systemic symptoms 120.22 10.04 141 511904 64103 79168240
Sinus pain 118.62 10.04 133 511912 3609 79228734
Septic shock 117.87 10.04 399 511646 122402 79109941
Drug-induced liver injury 117.52 10.04 151 511894 65966 79166377
Temperature regulation disorder 116.70 10.04 165 511880 5688 79226655
Chest X-ray abnormal 115.95 10.04 193 511852 7690 79224653
Sensitisation 115.94 10.04 124 511921 3187 79229156
Hepatotoxicity 115.33 10.04 96 511949 51256 79181087
Rheumatic fever 114.56 10.04 22 512023 28503 79203840
Rhonchi 112.09 10.04 134 511911 3902 79228441
Acute respiratory failure 111.92 10.04 710 511335 58831 79173512
Swollen tongue 111.49 10.04 555 511490 42015 79190328
Suicide attempt 111.20 10.04 228 511817 82704 79149639
Product delivery mechanism issue 110.98 10.04 42 512003 134 79232209
Obstruction 110.27 10.04 142 511903 4468 79227875
Bronchial hyperreactivity 110.26 10.04 116 511929 2924 79229419
Psoriatic arthropathy 110.14 10.04 208 511837 77791 79154552
Neuropathy peripheral 107.76 10.04 503 511542 140802 79091541
Alanine aminotransferase increased 106.88 10.04 609 511436 161961 79070382
Lip swelling 106.88 10.04 533 511512 40378 79191965
Cerebral infarction 106.83 10.04 82 511963 45594 79186749
Interstitial lung disease 106.61 10.04 368 511677 112232 79120111
Spirometry abnormal 106.32 10.04 70 511975 889 79231454
Neutrophil count decreased 105.43 10.04 284 511761 93675 79138668
Eye pruritus 103.38 10.04 329 511716 20241 79212102
Irritable bowel syndrome 102.72 10.04 150 511895 62091 79170252
Multiple allergies 102.34 10.04 215 511830 10245 79222098
Nasopharyngitis 102.06 10.04 2239 509806 251642 78980701
Status asthmaticus 101.53 10.04 70 511975 964 79231379
General physical health deterioration 101.14 10.04 1205 510840 274033 78958310
Lung consolidation 100.78 10.04 195 511850 8752 79223591
Maternal exposure during pregnancy 100.63 10.04 492 511553 136046 79096297
Sneezing 100.00 10.04 316 511729 19367 79212976
Posterior reversible encephalopathy syndrome 97.96 10.04 24 512021 26257 79206086
Renal failure 97.93 10.04 822 511223 200146 79032197
Hepatocellular injury 97.33 10.04 97 511948 47496 79184847
Eosinophilic bronchitis 96.81 10.04 52 511993 440 79231903
Rhinitis 96.66 10.04 260 511785 14547 79217796
Therapy non-responder 96.21 10.04 289 511756 92016 79140327
Total lung capacity decreased 95.09 10.04 105 511940 2800 79229543
Throat tightness 94.88 10.04 393 511652 27514 79204829
Viral infection 93.65 10.04 533 511512 42483 79189860
Disseminated intravascular coagulation 93.62 10.04 57 511988 35785 79196558
Eosinophilia 93.61 10.04 554 511491 44791 79187552
Swollen joint count increased 93.54 10.04 17 512028 22910 79209433
Serotonin syndrome 92.97 10.04 91 511954 44936 79187407
Toxic epidermal necrolysis 92.16 10.04 90 511955 44491 79187852
Lung diffusion test decreased 91.00 10.04 72 511973 1238 79231105
Aspartate aminotransferase increased 90.78 10.04 520 511525 138121 79094222
Blood calcium decreased 90.65 10.04 425 511620 31394 79200949
Body temperature increased 90.61 10.04 541 511504 43879 79188464
Increased bronchial secretion 90.01 10.04 109 511936 3218 79229125
Anaphylactic reaction 89.34 10.04 876 511169 82867 79149476
Eczema 89.01 10.04 506 511539 40312 79192031
Humidity intolerance 88.54 10.04 46 511999 361 79231982
Agranulocytosis 88.44 10.04 95 511950 44935 79187408
Diarrhoea 88.35 10.04 4689 507356 875800 78356543
Pyrexia 87.64 10.04 3517 508528 675192 78557151
Pneumocystis jirovecii pneumonia 87.31 10.04 50 511995 32458 79199885
Neoplasm progression 86.82 10.04 123 511922 51559 79180784
Altered state of consciousness 86.57 10.04 92 511953 43730 79188613
Tubulointerstitial nephritis 86.45 10.04 71 511974 38164 79194179
Smoke sensitivity 85.92 10.04 52 511993 564 79231779
Device malfunction 85.03 10.04 317 511728 21131 79211212
Cerebral haemorrhage 84.81 10.04 150 511895 57523 79174820
Diastolic hypotension 84.78 10.04 35 512010 149 79232194
Chronic sinusitis 84.30 10.04 228 511817 12798 79219545
Burning sensation 84.28 10.04 655 511390 57977 79174366
Arthralgia 84.04 10.04 2917 509128 568886 78663457
Orthostatic hypotension 83.84 10.04 633 511412 55531 79176812
Swelling 82.98 10.04 940 511105 215771 79016572
Poisoning 81.65 10.04 30 512015 25242 79207101
Ejection fraction 81.26 10.04 86 511959 2183 79230160
Vocal cord dysfunction 80.88 10.04 50 511995 565 79231778
Palmar-plantar erythrodysaesthesia syndrome 80.71 10.04 57 511988 33077 79199266
Bronchiolitis 80.47 10.04 116 511929 4072 79228271
Perfume sensitivity 80.46 10.04 57 511988 822 79231521
Blister 79.91 10.04 445 511600 119031 79113312
Haematotoxicity 79.70 10.04 5 512040 15514 79216829
Coeliac disease 78.87 10.04 204 511841 11147 79221196
Lower respiratory tract congestion 78.69 10.04 112 511933 3885 79228458
Total lung capacity increased 78.60 10.04 85 511960 2213 79230130
Thrombotic microangiopathy 78 10.04 17 512028 20152 79212191
Neurotoxicity 77.82 10.04 57 511988 32461 79199882
C-reactive protein abnormal 77.45 10.04 119 511926 48248 79184095
Blood creatinine increased 77.44 10.04 630 511415 154427 79077916
Blood lactate dehydrogenase increased 76.52 10.04 83 511962 39087 79193256
Rhabdomyolysis 76.34 10.04 371 511674 102760 79129583
Stress 75.97 10.04 814 511231 78798 79153545
Choking 75.52 10.04 209 511836 11892 79220451
Sputum purulent 74.67 10.04 65 511980 1284 79231059
Hepatic failure 74.09 10.04 178 511867 61034 79171309
Cytokine release syndrome 74.03 10.04 73 511972 35925 79196418
Metastases to liver 73.99 10.04 45 512000 28269 79204074
Decreased appetite 73.58 10.04 1656 510389 340762 78891581
Swelling face 73.57 10.04 740 511305 70472 79161871
Confusional state 72.91 10.04 1522 510523 316475 78915868
Death 72.55 10.04 2938 509107 563576 78668767
Transplant rejection 71.96 10.04 18 512027 19419 79212924
Poisoning deliberate 70.56 10.04 17 512028 18811 79213532
Knee arthroplasty 69.64 10.04 106 511939 43142 79189201
Drug eruption 69.49 10.04 109 511936 43826 79188517
Sinus congestion 69.07 10.04 282 511763 19614 79212729
Progressive multifocal leukoencephalopathy 69.05 10.04 23 512022 20577 79211766
Hip arthroplasty 68.49 10.04 77 511968 35679 79196664
Lung disorder 67.95 10.04 804 511241 79753 79152590
Balance disorder 67.91 10.04 950 511095 97907 79134436
Multiple organ dysfunction syndrome 67.90 10.04 472 511573 119774 79112569
Joint range of motion decreased 67.86 10.04 68 511977 33214 79199129
Nasal discharge discolouration 67.24 10.04 82 511963 2439 79229904
Red blood cell sedimentation rate increased 67.09 10.04 120 511925 45822 79186521
Nasal turbinate hypertrophy 66.92 10.04 47 511998 668 79231675
Forced expiratory flow decreased 66.73 10.04 34 512011 255 79232088
Cholestasis 66.72 10.04 147 511898 51962 79180381
Encephalopathy 66.71 10.04 216 511829 67181 79165162
Animal scratch 65.89 10.04 63 511982 1411 79230932
Pharyngeal swelling 65.68 10.04 150 511895 7569 79224774
Throat irritation 65.40 10.04 469 511576 40477 79191866
Palpitations 64.38 10.04 1157 510888 125453 79106890
Cardiac failure 64.34 10.04 659 511386 154183 79078160
Acute myeloid leukaemia 64.24 10.04 62 511983 30823 79201520
Cystic fibrosis respiratory infection suppression 63.27 10.04 38 512007 406 79231937
Osteonecrosis of jaw 63.04 10.04 113 511932 43113 79189230
Inhalation therapy 63.01 10.04 21 512024 40 79232303
Paranasal sinus discomfort 62.75 10.04 107 511938 4349 79227994
Circumstance or information capable of leading to medication error 62.59 10.04 100 511945 3848 79228495
Sputum abnormal 62.18 10.04 57 511988 1208 79231135
Right atrial hypertrophy 61.49 10.04 46 511999 725 79231618
Nasal mucosal disorder 60.66 10.04 35 512010 345 79231998
Blood pressure systolic increased 60.27 10.04 677 511368 66309 79166034
Cardiotoxicity 59.82 10.04 5 512040 12234 79220109
Lung diffusion test abnormal 59.81 10.04 35 512010 355 79231988
Fluid retention 59.43 10.04 698 511347 69111 79163232
Immune reconstitution inflammatory syndrome 59.27 10.04 9 512036 13832 79218511
FEV1/FVC ratio decreased 58.58 10.04 29 512016 203 79232140
Myelodysplastic syndrome 58.32 10.04 65 511980 30236 79202107
Shock 58.14 10.04 120 511925 43428 79188915
Panniculitis 57.94 10.04 6 512039 12365 79219978
Lymph node calcification 57.80 10.04 35 512010 380 79231963
Appendicolith 57.69 10.04 152 511893 8399 79223944
Sinus operation 57.63 10.04 76 511969 2449 79229894
Discomfort 57.52 10.04 522 511523 125095 79107248
Liver disorder 57.45 10.04 254 511791 72163 79160180
Limb injury 56.66 10.04 354 511691 29174 79203169
Anuria 56.64 10.04 32 512013 20931 79211412
Bacterial disease carrier 56.08 10.04 59 511986 1487 79230856
Migraine 55.80 10.04 830 511215 86663 79145680
Alveolar osteitis 55.63 10.04 45 512000 800 79231543
No adverse event 55.40 10.04 419 511626 36773 79195570
Neuroleptic malignant syndrome 55.40 10.04 57 511988 27502 79204841
Rash maculo-papular 54.62 10.04 181 511864 55897 79176446
Depression 54.58 10.04 1799 510246 214991 79017352
Cardiac arrest 54.49 10.04 777 511268 171319 79061024
Urinary tract discomfort 54.23 10.04 42 512003 699 79231644
Frustration tolerance decreased 53.33 10.04 136 511909 7366 79224977
Polyneuropathy 53.19 10.04 46 511999 24105 79208238
Gamma-glutamyltransferase increased 52.90 10.04 177 511868 54503 79177840
Crepitations 52.90 10.04 163 511882 9854 79222489
Blood pressure increased 52.45 10.04 1751 510294 209609 79022734
Constipation 52.14 10.04 2269 509776 280781 78951562
Airway remodelling 52.11 10.04 29 512016 265 79232078
Muscle spasticity 52.05 10.04 274 511771 21201 79211142
Proteinuria 52.01 10.04 80 511965 32422 79199921
Colitis 51.80 10.04 268 511777 73039 79159304
Superinfection 51.78 10.04 104 511941 4798 79227545
Enthesopathy 50.98 10.04 7 512038 11601 79220742
Therapy partial responder 50.81 10.04 24 512021 17373 79214970
Lung opacity 50.21 10.04 106 511939 5068 79227275
Extrapyramidal disorder 50.18 10.04 43 512002 22636 79209707
Rubber sensitivity 50.11 10.04 59 511986 1690 79230653
Drug tolerance decreased 50.06 10.04 11 512034 12967 79219376
Haemophagocytic lymphohistiocytosis 50.05 10.04 40 512005 21797 79210546
Graft versus host disease 49.98 10.04 17 512028 15009 79217334
Product container issue 49.95 10.04 51 511994 1240 79231103
Prescribed underdose 49.81 10.04 70 511975 29444 79202899
Hepatic cytolysis 49.29 10.04 61 511984 27090 79205253
Respiratory failure 49.12 10.04 1515 510530 179396 79052947
Infective exacerbation of chronic obstructive airways disease 49.00 10.04 74 511971 2710 79229633
Hypercapnia 48.69 10.04 147 511898 8788 79223555
Inflammation 48.61 10.04 377 511668 93376 79138967
Respiratory tract inflammation 48.40 10.04 42 512003 826 79231517
Mycotic allergy 48.17 10.04 54 511991 1465 79230878
Tumour lysis syndrome 47.57 10.04 50 511995 23889 79208454
Hyperkalaemia 47.46 10.04 487 511558 113911 79118432
Cytomegalovirus viraemia 47.22 10.04 12 512033 12809 79219534
Blood parathyroid hormone decreased 47.12 10.04 6 512039 10530 79221813
Hypercalcaemia 47.10 10.04 111 511934 38319 79194024
Metabolic acidosis 47.06 10.04 323 511722 82206 79150137
Prolonged expiration 46.99 10.04 49 511996 1222 79231121
Sedation 46.92 10.04 525 511520 51370 79180973
Lymphopenia 46.27 10.04 78 511967 30479 79201864
Congenital hiatus hernia 46.21 10.04 40 512005 784 79231559
Bradycardia 46.15 10.04 603 511442 134954 79097389
Increased upper airway secretion 45.78 10.04 90 511955 4087 79228256
Exposure to allergen 45.55 10.04 28 512017 313 79232030
Dyspnoea at rest 45.45 10.04 126 511919 7176 79225167
Venoocclusive liver disease 45.36 10.04 10 512035 11761 79220582
Emotional distress 45.04 10.04 423 511622 39546 79192797
Drug ineffective for unapproved indication 44.83 10.04 173 511872 51065 79181278
Back pain 44.75 10.04 2385 509660 301795 78930548
Nasal disorder 44.74 10.04 84 511961 3685 79228658
Pathogen resistance 44.71 10.04 18 512027 14324 79218019
Blood iron decreased 44.58 10.04 207 511838 15227 79217116
Nasal inflammation 44.27 10.04 37 512008 690 79231653
Cytomegalovirus infection reactivation 44.19 10.04 3 512042 8713 79223630
Aphonia 43.91 10.04 156 511889 10156 79222187
Product complaint 43.82 10.04 186 511859 13163 79219180
Colorectal cancer 43.77 10.04 3 512042 8644 79223699
Hyperammonaemia 43.62 10.04 9 512036 11084 79221259
Somnolence 43.61 10.04 1184 510861 237797 78994546
Eye swelling 43.33 10.04 305 511740 26163 79206180
Gastrointestinal disorder 43.31 10.04 539 511506 121666 79110677
Increased viscosity of bronchial secretion 43.02 10.04 33 512012 541 79231802
Febrile bone marrow aplasia 42.84 10.04 15 512030 13005 79219338
Respiratory tract irritation 42.67 10.04 34 512011 591 79231752
Hyperbilirubinaemia 42.53 10.04 57 511988 24461 79207882
Cognitive disorder 42.52 10.04 658 511387 69268 79163075
Incorrect dose administered 42.44 10.04 710 511335 75920 79156423
Shock haemorrhagic 42.04 10.04 40 512005 20020 79212323
Chronic respiratory failure 41.81 10.04 72 511973 2950 79229393
Infection 41.68 10.04 1207 510838 240505 78991838
Skin necrosis 41.62 10.04 33 512012 18054 79214289
Drug level increased 41.41 10.04 124 511921 39527 79192816
Hyperthermia 41.39 10.04 33 512012 18004 79214339
Disorientation 41.32 10.04 235 511810 62541 79169802
Rash erythematous 41.23 10.04 559 511486 57210 79175133
Bradyphrenia 41.08 10.04 9 512036 10631 79221712
Forced expiratory volume abnormal 40.80 10.04 19 512026 114 79232229
Sleep disorder 40.78 10.04 775 511270 84902 79147441
Cardiac disorder 40.45 10.04 620 511425 65137 79167206
Tenosynovitis 40.25 10.04 25 512020 15529 79216814
Panic attack 40.20 10.04 280 511765 23936 79208407
Right ventricular hypertrophy 40.06 10.04 51 511994 1586 79230757
Rheumatoid nodule 39.90 10.04 32 512013 17406 79214937
Status epilepticus 39.72 10.04 62 511983 24979 79207364
Atelectasis 39.72 10.04 348 511697 31909 79200434
Pulmonary congestion 39.63 10.04 304 511741 26796 79205547
Herpes zoster 39.54 10.04 394 511651 92689 79139654
Multiple-drug resistance 39.43 10.04 5 512040 8803 79223540
Lung diffusion disorder 39.37 10.04 21 512024 175 79232168
Haemoglobin decreased 39.35 10.04 1105 510940 221014 79011329
Polyp 39.23 10.04 128 511917 7979 79224364
Multiple drug therapy 38.94 10.04 83 511962 3995 79228348
Spinal muscular atrophy 38.91 10.04 27 512018 376 79231967
Hypertransaminasaemia 38.78 10.04 14 512031 11910 79220433
Aplasia 38.76 10.04 3 512042 7817 79224526
Suspected suicide 38.76 10.04 10 512035 10566 79221777
Seizure 38.61 10.04 920 511125 187914 79044429
Breast cancer stage III 38.58 10.04 8 512037 9818 79222525
Painful respiration 38.57 10.04 75 511970 3378 79228965
Aspirin-exacerbated respiratory disease 38.43 10.04 43 512002 1164 79231179
Ear pruritus 38.43 10.04 83 511962 4032 79228311
Hiatus hernia 38.38 10.04 269 511776 23043 79209300
Tunnel vision 38.36 10.04 49 511996 1529 79230814
Depressed mood 38.32 10.04 478 511567 48002 79184341
Metastases to bone 38.25 10.04 61 511984 24366 79207977
Ulcer 38.00 10.04 85 511960 29887 79202456
Stress cardiomyopathy 37.76 10.04 157 511888 11009 79221334
Pruritus 37.64 10.04 2982 509063 391666 78840677
Bronchial neoplasm 37.63 10.04 29 512016 479 79231864
Drug dependence 37.56 10.04 414 511631 40355 79191988
Epstein-Barr virus infection 37.55 10.04 23 512022 14393 79217950
Lung neoplasm malignant 37.48 10.04 306 511739 27486 79204857
Hypoalbuminaemia 37.47 10.04 49 511996 21248 79211095
Lacrimation increased 37.38 10.04 260 511785 22217 79210126
Insomnia 36.98 10.04 1927 510118 243243 78989100
Nephrectomy 36.92 10.04 56 511989 2059 79230284
Peritonitis 36.80 10.04 78 511967 27958 79204385
Leukoencephalopathy 36.74 10.04 4 512041 7925 79224418
Exercise tolerance decreased 36.73 10.04 135 511910 8936 79223407
Hyper IgE syndrome 36.73 10.04 30 512015 541 79231802
Nausea 36.66 10.04 5491 506554 951705 78280638
Product taste abnormal 36.66 10.04 58 511987 2213 79230130
Hepatitis cholestatic 36.22 10.04 22 512023 13830 79218513
Rhinovirus infection 36.20 10.04 123 511922 7830 79224513
Akathisia 36.17 10.04 20 512025 13239 79219104
Brain oedema 35.98 10.04 67 511978 25196 79207147
Diastolic dysfunction 35.77 10.04 151 511894 10660 79221683
Hypertensive crisis 35.31 10.04 49 511996 20721 79211622
Transplant dysfunction 35.16 10.04 3 512042 7218 79225125
Ataxia 35.14 10.04 67 511978 24972 79207371
Acute graft versus host disease in skin 35.14 10.04 4 512041 7654 79224689
Body temperature decreased 35.13 10.04 338 511707 31807 79200536
Bronchomalacia 35.11 10.04 22 512023 255 79232088
Epilepsy 35.08 10.04 139 511906 40721 79191622
Decreased activity 34.88 10.04 129 511916 8565 79223778
Rhinitis perennial 34.84 10.04 24 512021 330 79232013
Sputum retention 34.79 10.04 39 512006 1058 79231285
Pulmonary toxicity 34.48 10.04 20 512025 12894 79219449
Factitious disorder 34.46 10.04 18 512027 143 79232200
Mouth swelling 34.34 10.04 101 511944 5950 79226393
Salpingo-oophorectomy unilateral 34.20 10.04 34 512011 800 79231543
Blood creatine phosphokinase increased 34.14 10.04 266 511779 65824 79166519
Blood pressure fluctuation 33.87 10.04 272 511773 66873 79165470
Haematochezia 33.58 10.04 380 511665 87265 79145078
Klebsiella infection 33.35 10.04 31 512014 15689 79216654
Wolff-Parkinson-White syndrome 33.31 10.04 22 512023 281 79232062
Nasal septum deviation 33.27 10.04 50 511995 1823 79230520
Enteritis 33.07 10.04 27 512018 14556 79217787
Pharyngeal oedema 33.06 10.04 198 511847 16074 79216269
Cystitis haemorrhagic 32.99 10.04 9 512036 9163 79223180
Malignant mediastinal neoplasm 32.93 10.04 43 512002 1372 79230971
BK virus infection 32.89 10.04 8 512037 8796 79223547
Metastases to lung 32.77 10.04 41 512004 18122 79214221
Toxic skin eruption 32.75 10.04 58 511987 22235 79210108
Broncholithiasis 32.65 10.04 20 512025 222 79232121
Carpal tunnel syndrome 32.54 10.04 226 511819 19302 79213041
Foreign body in reproductive tract 32.53 10.04 30 512015 641 79231702
Idiopathic intracranial hypertension 32.42 10.04 67 511978 3155 79229188
Atopy 32.33 10.04 25 512020 415 79231928
Sinusitis fungal 32.11 10.04 56 511989 2318 79230025
Lower respiratory tract infection bacterial 32.07 10.04 35 512010 921 79231422
Feeling abnormal 31.96 10.04 1288 510757 157911 79074432
Cockroach allergy 31.94 10.04 15 512030 92 79232251
Multiple sclerosis relapse 31.82 10.04 172 511873 46361 79185982
Immunodeficiency 31.73 10.04 244 511801 21524 79210819
Cholecystitis chronic 31.73 10.04 137 511908 9769 79222574
Kidney transplant rejection 31.71 10.04 13 512032 10233 79222110
Blood cholesterol increased 31.68 10.04 364 511681 83356 79148987
Sputum culture positive 31.65 10.04 73 511972 3708 79228635
Night sweats 31.59 10.04 490 511555 51605 79180738
Oesophageal spasm 31.47 10.04 69 511976 3387 79228956
Hypoacusis 31.47 10.04 314 511731 29836 79202507
Alanine aminotransferase abnormal 31.34 10.04 9 512036 8858 79223485
Skin ulcer 31.33 10.04 211 511834 53939 79178404
Exposure to toxic agent 31.09 10.04 10 512035 9148 79223195
Mucormycosis 31.05 10.04 8 512037 8461 79223882
Musculoskeletal pain 31.03 10.04 466 511579 101888 79130455
Subdural haematoma 30.92 10.04 101 511944 31333 79201010
Eosinophil count 30.75 10.04 16 512029 126 79232217
Prostate cancer 30.62 10.04 110 511935 33158 79199185
Neurodevelopmental disorder 30.45 10.04 12 512033 44 79232299
Basal cell carcinoma 30.30 10.04 130 511915 37245 79195098
Hepatitis B 30.30 10.04 8 512037 8324 79224019
Skin toxicity 30.20 10.04 8 512037 8306 79224037
Product use issue 29.88 10.04 1074 510971 208748 79023595
Nightmare 29.79 10.04 275 511770 25586 79206757
Ejection fraction abnormal 29.74 10.04 55 511990 2385 79229958
Ear congestion 29.73 10.04 61 511984 2858 79229485
Dehydration 29.59 10.04 1297 510748 246890 78985453
Diffuse large B-cell lymphoma 29.45 10.04 21 512024 12128 79220215
Rebound nasal congestion 29.37 10.04 10 512035 21 79232322
Uveitis 29.32 10.04 39 512006 16791 79215552
Oliguria 29.23 10.04 37 512008 16272 79216071
Hepatic cirrhosis 29.17 10.04 120 511925 34786 79197557
Product use in unapproved indication 29.10 10.04 1312 510733 249047 78983296
Snoring 28.86 10.04 90 511955 5476 79226867
Sleep terror 28.82 10.04 78 511967 4380 79227963
Intentional self-injury 28.65 10.04 109 511936 32310 79200033
Aphthous ulcer 28.56 10.04 40 512005 16849 79215494
Hepatitis B reactivation 28.51 10.04 3 512042 6105 79226238
Distal intestinal obstruction syndrome 28.49 10.04 30 512015 757 79231586
Rib deformity 28.20 10.04 18 512027 216 79232127
Anosmia 28.09 10.04 122 511923 8722 79223621
Blood alkaline phosphatase increased 28.08 10.04 267 511778 63397 79168946
Osteoporosis 28.02 10.04 496 511549 53616 79178727
Pregnancy 28.02 10.04 84 511961 26767 79205576
Ventilation perfusion mismatch 27.94 10.04 27 512018 613 79231730
Carbon dioxide increased 27.94 10.04 51 511994 2189 79230154
Scoliosis 27.68 10.04 108 511937 7356 79224987
Acute hepatic failure 27.43 10.04 100 511945 30013 79202330
Stridor 27.20 10.04 87 511958 5366 79226977
Victim of child abuse 27.06 10.04 32 512013 921 79231422
Gastric cancer 26.85 10.04 16 512029 10163 79222180
Aplastic anaemia 26.84 10.04 46 511999 17859 79214484
Joint stiffness 26.78 10.04 153 511892 40677 79191666
Nephropathy toxic 26.64 10.04 57 511988 20362 79211981
Crying 26.53 10.04 245 511800 22798 79209545
Jaundice 26.50 10.04 217 511828 53132 79179211
Adverse event 26.36 10.04 253 511792 59961 79172382
Femur fracture 26.36 10.04 143 511902 38509 79193834
Dermatitis exfoliative generalised 26.24 10.04 7 512038 7234 79225109
Generalised tonic-clonic seizure 25.95 10.04 170 511875 43740 79188603
Forced expiratory volume increased 25.91 10.04 11 512034 51 79232292
Bladder cancer 25.90 10.04 54 511991 19472 79212871
Drug hypersensitivity 25.78 10.04 1614 510431 297302 78935041
Forced expiratory volume 25.68 10.04 13 512032 96 79232247
Renal tubular necrosis 25.65 10.04 79 511966 24960 79207383
Hyposmia 25.65 10.04 28 512017 737 79231606
Osteomyelitis 25.62 10.04 116 511929 32749 79199594
Total lung capacity abnormal 25.61 10.04 17 512028 219 79232124
Endometrial ablation 25.38 10.04 30 512015 863 79231480
Intentional product misuse 25.29 10.04 444 511601 94721 79137622
Blood immunoglobulin E decreased 25.13 10.04 13 512032 101 79232242
Cardiac failure congestive 24.97 10.04 1136 510909 141266 79091077
Cytopenia 24.88 10.04 59 511986 20324 79212019
Pickwickian syndrome 24.80 10.04 22 512023 446 79231897
Delirium 24.73 10.04 388 511657 84239 79148104
Exostosis 24.64 10.04 44 512001 16814 79215529
Myalgia 24.61 10.04 1442 510603 184199 79048144
Use of accessory respiratory muscles 24.46 10.04 23 512022 504 79231839
Sepsis 24.43 10.04 1448 510597 267980 78964363
Influenza B virus test positive 24.42 10.04 20 512025 362 79231981
Colitis microscopic 24.34 10.04 20 512025 10748 79221595
Nystagmus 24.17 10.04 17 512028 9887 79222456
Bladder pain 23.99 10.04 49 511996 2288 79230055
Gastrointestinal toxicity 23.97 10.04 11 512034 8098 79224245
Eosinophilic oesophagitis 23.96 10.04 24 512021 570 79231773
Respiratory syncytial virus bronchiolitis 23.93 10.04 22 512023 468 79231875
Haemorrhage intracranial 23.85 10.04 87 511958 26106 79206237
Infusion site erythema 23.83 10.04 122 511923 9338 79223005
Ventricular failure 23.81 10.04 23 512022 522 79231821
Subarachnoid haemorrhage 23.79 10.04 79 511966 24386 79207957
Soft tissue mass 23.77 10.04 35 512010 1253 79231090
Nasal oedema 23.75 10.04 41 512004 1683 79230660
Toxic encephalopathy 23.75 10.04 23 512022 11417 79220926
Enterococcal infection 23.69 10.04 40 512005 15620 79216723
Stoma closure 23.68 10.04 18 512027 291 79232052
Pulmonary embolism 23.65 10.04 1338 510707 170316 79062027
Hypersensitivity 23.60 10.04 1973 510072 260266 78972077
Unintentional medical device removal 23.52 10.04 10 512035 7702 79224641
Fungal disease carrier 23.52 10.04 19 512026 337 79232006
Respiratory syncytial virus infection 23.50 10.04 121 511924 9281 79223062
Respiratory arrest 23.45 10.04 246 511799 57304 79175039
Retinitis 23.42 10.04 4 512041 5639 79226704
Transaminases increased 23.25 10.04 216 511829 51527 79180816
Mydriasis 23.22 10.04 49 511996 17594 79214749
Respiratory gas exchange disorder 23.22 10.04 28 512017 823 79231520
Anger 23.16 10.04 189 511856 16973 79215370
Pancreatic carcinoma 23.11 10.04 32 512013 13545 79218798
Sinus tachycardia 23.08 10.04 349 511696 36559 79195784
Squamous cell carcinoma of skin 22.97 10.04 34 512011 13999 79218344
Blood cholesterol 22.84 10.04 25 512020 660 79231683
Nasal turbinate abnormality 22.84 10.04 9 512036 33 79232310
Mixed liver injury 22.84 10.04 10 512035 7568 79224775
Blood bilirubin increased 22.76 10.04 294 511751 65938 79166405
Rectal prolapse 22.76 10.04 46 511999 2132 79230211
Metastases to lymph nodes 22.66 10.04 20 512025 10377 79221966
Parathyroid gland enlargement 22.59 10.04 14 512031 159 79232184
Foot deformity 22.56 10.04 79 511966 23995 79208348
Cytomegalovirus chorioretinitis 22.55 10.04 4 512041 5486 79226857
Haemophilus infection 22.52 10.04 47 511998 2229 79230114
Aplasia pure red cell 22.46 10.04 11 512034 7799 79224544
Embolism venous 22.40 10.04 69 511976 4170 79228173
Psychomotor retardation 22.37 10.04 6 512039 6178 79226165
Ischaemic stroke 22.36 10.04 123 511922 33008 79199335
Polymyalgia rheumatica 22.28 10.04 72 511973 4465 79227878
Drug use disorder 22.26 10.04 14 512031 8637 79223706
Paraesthesia oral 22.24 10.04 215 511830 20256 79212087
Epidural lipomatosis 22.13 10.04 33 512012 1195 79231148
Oropharyngeal discomfort 22.11 10.04 98 511947 7068 79225275
Sarcoidosis 22.05 10.04 109 511936 8226 79224117
Vascular shunt 22.04 10.04 10 512035 56 79232287
Arthritis bacterial 22.02 10.04 16 512029 9150 79223193
Enterocolitis 22.01 10.04 37 512008 14475 79217868
Pneumothorax spontaneous 21.92 10.04 36 512009 1418 79230925
Oxygen consumption increased 21.78 10.04 76 511969 4903 79227440
Blood urea increased 21.78 10.04 204 511841 48586 79183757
Osteonecrosis 21.78 10.04 114 511931 30981 79201362
Graft versus host disease in skin 21.77 10.04 6 512039 6067 79226276
Wrong technique in device usage process 21.69 10.04 66 511979 3962 79228381
Breast cancer stage I 21.56 10.04 8 512037 6692 79225651
Nocturnal dyspnoea 21.53 10.04 38 512007 1588 79230755
Benign prostatic hyperplasia 21.52 10.04 138 511907 11474 79220869
Cystic fibrosis related diabetes 21.49 10.04 15 512030 211 79232132
Fracture 21.48 10.04 70 511975 21731 79210612
Pemphigoid 21.47 10.04 41 512004 15274 79217069
Graft versus host disease in gastrointestinal tract 21.47 10.04 7 512038 6349 79225994
Myoclonus 21.34 10.04 98 511947 27562 79204781
Oxygen therapy 21.33 10.04 52 511993 2738 79229605
Suffocation feeling 21.25 10.04 39 512006 1681 79230662
Psychotic disorder 21.21 10.04 167 511878 41235 79191108
Pulmonary hypertension 21.21 10.04 430 511615 47650 79184693
Angle closure glaucoma 21.21 10.04 54 511991 2922 79229421
Cervix neoplasm 21.18 10.04 14 512031 179 79232164
Lymphoproliferative disorder 21.18 10.04 5 512040 5610 79226733
Infusion site swelling 21.18 10.04 103 511942 7723 79224620
Decreased bronchial secretion 21.07 10.04 10 512035 63 79232280
Rib fracture 21.00 10.04 273 511772 27674 79204669
Vocal cord disorder 20.99 10.04 36 512009 1470 79230873
Facet joint syndrome 20.93 10.04 25 512020 11277 79221066
Muscle rigidity 20.89 10.04 62 511983 19820 79212523
Multimorbidity 20.85 10.04 35 512010 1404 79230939
Croup infectious 20.83 10.04 25 512020 731 79231612
Uterine perforation 20.83 10.04 88 511957 6215 79226128
Functional residual capacity increased 20.79 10.04 11 512034 90 79232253
Respiratory acidosis 20.70 10.04 133 511912 11067 79221276
Drug level decreased 20.68 10.04 38 512007 14364 79217979
Endometriosis 20.60 10.04 61 511984 3607 79228736
Hepatitis toxic 20.60 10.04 4 512041 5143 79227200
Separation anxiety disorder 20.58 10.04 8 512037 28 79232315
Immune effector cell-associated neurotoxicity syndrome 20.55 10.04 6 512039 5842 79226501
Breast cancer female 20.54 10.04 26 512019 11435 79220908
Skin candida 20.54 10.04 43 512002 2044 79230299
Dermatitis allergic 20.49 10.04 192 511853 17938 79214405
Coagulopathy 20.48 10.04 141 511904 35865 79196478
Bacteraemia 20.47 10.04 125 511920 32699 79199644
Foreign body aspiration 20.43 10.04 17 512028 315 79232028
Lupus-like syndrome 20.41 10.04 36 512009 13821 79218522
Anal abscess 20.38 10.04 18 512027 9337 79223006
Rash 20.36 10.04 3333 508712 575025 78657318
Bronchial haemorrhage 20.33 10.04 33 512012 1287 79231056
Hypotension 20.33 10.04 2496 509549 437821 78794522
Peak expiratory flow rate abnormal 20.29 10.04 11 512034 95 79232248
Influenza immunisation 20.27 10.04 5 512040 0 79232343
Impaired work ability 20.23 10.04 62 511983 19619 79212724
Acute respiratory distress syndrome 20.21 10.04 183 511862 43884 79188459
Stevens-Johnson syndrome 20.06 10.04 158 511887 39008 79193335
Oesophageal polyp 19.97 10.04 10 512035 72 79232271
Breast conserving surgery 19.95 10.04 25 512020 765 79231578
Hyperuricaemia 19.89 10.04 28 512017 11771 79220572
Haemolytic anaemia 19.88 10.04 54 511991 17766 79214577
Neutropenic colitis 19.79 10.04 6 512039 5701 79226642
Ear discomfort 19.77 10.04 108 511937 8475 79223868
Hypertriglyceridaemia 19.77 10.04 32 512013 12708 79219635
Nasal mucosal discolouration 19.77 10.04 8 512037 32 79232311
Hypocalcaemia 19.70 10.04 215 511830 49709 79182634
Bronchopulmonary aspergillosis 19.68 10.04 75 511970 22219 79210124
C-reactive protein 19.66 10.04 4 512041 4975 79227368
Pharyngitis streptococcal 19.66 10.04 127 511918 10587 79221756
Labelled drug-drug interaction medication error 19.58 10.04 101 511944 27549 79204794
Acute generalised exanthematous pustulosis 19.46 10.04 52 511993 17202 79215141
Cholestatic liver injury 19.44 10.04 4 512041 4937 79227406
Upper respiratory fungal infection 19.44 10.04 17 512028 338 79232005
Central obesity 19.37 10.04 38 512007 1723 79230620
Attention-seeking behaviour 19.36 10.04 11 512034 105 79232238
Nephrotic syndrome 19.36 10.04 26 512019 11148 79221195
Pulmonary pain 19.33 10.04 68 511977 4405 79227938
Erythema multiforme 19.31 10.04 54 511991 17597 79214746
Hemiparesis 19.24 10.04 132 511913 33601 79198742
Cor pulmonale 19.22 10.04 44 512001 2224 79230119
Tremor 19.21 10.04 1303 510742 168780 79063563
Device related infection 19.16 10.04 135 511910 34159 79198184
Deformity 19.15 10.04 20 512025 9585 79222758
Haemodynamic instability 19.14 10.04 53 511992 17329 79215014
Hypothyroidism 19.12 10.04 456 511589 51936 79180407
Gastrointestinal haemorrhage 19.06 10.04 765 511280 146954 79085389
Visual acuity reduced 19.02 10.04 111 511934 29358 79202985
Skin laceration 18.95 10.04 276 511769 28686 79203657
Heart sounds 18.92 10.04 27 512018 939 79231404
Ejection fraction decreased 18.89 10.04 137 511908 34440 79197903
Injection site scab 18.87 10.04 17 512028 352 79231991
Pseudomonal sepsis 18.84 10.04 8 512037 6166 79226177
Anti-cyclic citrullinated peptide antibody 18.81 10.04 7 512038 5845 79226498
Intervertebral discitis 18.81 10.04 4 512041 4824 79227519
Disease complication 18.77 10.04 72 511973 4865 79227478
Inspiratory capacity abnormal 18.68 10.04 11 512034 113 79232230
Nervousness 18.64 10.04 310 511735 33105 79199238
Dermatitis acneiform 18.62 10.04 22 512023 9971 79222372
Sinus polyp 18.58 10.04 20 512025 518 79231825
Clostridium difficile colitis 18.57 10.04 126 511919 32157 79200186
Influenza like illness 18.52 10.04 597 511448 71110 79161233
Feeling cold 18.49 10.04 273 511772 28456 79203887
Bronchitis bacterial 18.48 10.04 34 512011 1468 79230875
Tachypnoea 18.46 10.04 299 511746 31764 79200579
Complication of device removal 18.45 10.04 61 511984 3828 79228515
Spinal pain 18.43 10.04 45 512000 15347 79216996
Temperature intolerance 18.40 10.04 116 511929 9589 79222754
International normalised ratio increased 18.36 10.04 409 511636 84312 79148031
Carcinoid tumour pulmonary 18.29 10.04 17 512028 367 79231976
Complications of transplanted kidney 18.26 10.04 9 512036 6357 79225986
Acute lymphocytic leukaemia recurrent 18.23 10.04 4 512041 4720 79227623
Peripheral sensory neuropathy 18.18 10.04 35 512010 12998 79219345
Weight decreased 18.18 10.04 2574 509471 352624 78879719
Ileus paralytic 18.12 10.04 21 512024 9599 79222744
Gallbladder injury 18.10 10.04 30 512015 1191 79231152
Cardiac murmur 18.09 10.04 168 511877 15656 79216687
Hereditary angioedema 18.03 10.04 75 511970 5260 79227083
Gastroenteritis viral 18.01 10.04 241 511804 24590 79207753
Electrocardiogram QRS complex prolonged 17.98 10.04 26 512019 10807 79221536
Paranasal sinus hypersecretion 17.96 10.04 60 511985 3786 79228557
Product administered to patient of inappropriate age 17.94 10.04 77 511968 5476 79226867
Small airways disease 17.90 10.04 7 512038 25 79232318
Accidental overdose 17.88 10.04 165 511880 39416 79192927
Right atrial enlargement 17.88 10.04 17 512028 378 79231965
Pneumonia lipoid 17.86 10.04 12 512033 158 79232185
Nasal pruritus 17.86 10.04 20 512025 542 79231801
Retinal haemorrhage 17.67 10.04 16 512029 8201 79224142
Immune thrombocytopenia 17.66 10.04 57 511988 17748 79214595
Cerebral haematoma 17.64 10.04 15 512030 7927 79224416
Wrong patient received product 17.64 10.04 4 512041 4614 79227729
Pharyngeal erythema 17.62 10.04 40 512005 2010 79230333
Increased viscosity of upper respiratory secretion 17.61 10.04 16 512029 335 79232008
Red blood cell sedimentation rate abnormal 17.56 10.04 72 511973 20891 79211452
Familial periodic paralysis 17.54 10.04 12 512033 163 79232180
Adenovirus infection 17.52 10.04 17 512028 8430 79223913
Brain abscess 17.46 10.04 5 512040 4931 79227412
Infusion site extravasation 17.44 10.04 118 511927 9990 79222353
Eosinophilic pneumonia chronic 17.44 10.04 19 512026 499 79231844
Musculoskeletal chest pain 17.41 10.04 239 511806 24525 79207818
Insurance issue 17.38 10.04 78 511967 5655 79226688
Exposure to fungus 17.38 10.04 11 512034 130 79232213
Dizziness 17.32 10.04 3727 508318 522714 78709629
Hypothermia 17.31 10.04 81 511964 22665 79209678
Infusion site pruritus 17.28 10.04 62 511983 4056 79228287
Incorrect dose administered by product 17.27 10.04 13 512032 207 79232136
Ear infection 17.26 10.04 314 511731 34118 79198225
Gastric haemorrhage 17.25 10.04 45 512000 15005 79217338
Pneumococcal sepsis 17.24 10.04 35 512010 1627 79230716
Lip discolouration 17.24 10.04 22 512023 686 79231657
Asthma exercise induced 17.23 10.04 11 512034 132 79232211
Second primary malignancy 17.15 10.04 42 512003 14308 79218035
Frequent bowel movements 17.14 10.04 115 511930 29424 79202919
Sarcopenia 17.13 10.04 18 512027 453 79231890
Device defective 17.11 10.04 38 512007 1882 79230461
Infusion site mass 17.07 10.04 34 512011 1559 79230784
PCO2 increased 17.05 10.04 37 512008 1803 79230540
Inappropriate antidiuretic hormone secretion 17.04 10.04 99 511946 26214 79206129
Red blood cell count decreased 17.03 10.04 263 511782 57250 79175093
Overweight 17.00 10.04 62 511983 4088 79228255
Urosepsis 16.99 10.04 100 511945 26395 79205948
Escherichia infection 16.96 10.04 59 511986 17958 79214385
Intentional device misuse 16.95 10.04 23 512022 762 79231581
Magnetic resonance imaging thoracic abnormal 16.91 10.04 6 512039 15 79232328
Renal cancer 16.91 10.04 33 512012 12193 79220150
Hyperpyrexia 16.89 10.04 9 512036 6083 79226260
Blood phosphorus increased 16.80 10.04 119 511926 10228 79222115
Hepatic cancer 16.76 10.04 26 512019 10503 79221840
Condition aggravated 16.75 10.04 2896 509149 498228 78734115
Tracheomalacia 16.75 10.04 16 512029 358 79231985
Factor V Leiden mutation 16.71 10.04 12 512033 177 79232166
Motor neurone disease 16.58 10.04 20 512025 588 79231755
Oral candidiasis 16.58 10.04 275 511770 29353 79202990
Functional residual capacity decreased 16.57 10.04 9 512036 78 79232265
Sciatica 16.56 10.04 135 511910 33087 79199256
Metastasis 16.54 10.04 12 512033 6868 79225475
Metastases to central nervous system 16.54 10.04 52 511993 16323 79216020
Laryngeal stenosis 16.49 10.04 27 512018 1061 79231282
Restlessness 16.49 10.04 205 511840 46287 79186056
Acute graft versus host disease in intestine 16.48 10.04 3 512042 4038 79228305
Inguinal hernia repair 16.48 10.04 15 512030 315 79232028
Dyskinesia 16.42 10.04 196 511849 44577 79187766
Sinonasal obstruction 16.40 10.04 15 512030 317 79232026
Metastases to peritoneum 16.28 10.04 4 512041 4368 79227975
Nicotine dependence 16.27 10.04 25 512020 930 79231413
Appetite disorder 16.26 10.04 95 511950 7644 79224699
Product availability issue 16.20 10.04 59 511986 3888 79228455
Scleritis 16.19 10.04 4 512041 4352 79227991
Cytomegalovirus test positive 16.18 10.04 9 512036 5938 79226405
Brain injury 16.18 10.04 128 511917 11389 79220954
Erysipelas 16.15 10.04 28 512017 10822 79221521
Pneumonia pseudomonal 16.14 10.04 78 511967 5833 79226510
Mood swings 16.14 10.04 197 511848 19683 79212660
Pulmonary tuberculosis 16.11 10.04 16 512029 7849 79224494
Cytomegalovirus colitis 16.11 10.04 5 512040 4680 79227663
Mycobacterium test positive 16.05 10.04 17 512028 432 79231911
Appendicitis 15.99 10.04 204 511841 20590 79211753
Grip strength decreased 15.99 10.04 79 511966 21790 79210553
Encephalitis toxic 15.98 10.04 14 512031 279 79232064
Tracheal disorder 15.98 10.04 18 512027 491 79231852
Tongue pruritus 15.95 10.04 19 512026 551 79231792
Body mass index increased 15.83 10.04 37 512008 1896 79230447
Substance abuse 15.82 10.04 27 512018 10499 79221844
Allergic cough 15.80 10.04 21 512024 682 79231661
Tooth disorder 15.79 10.04 101 511944 26132 79206211
Pneumonia aspiration 15.76 10.04 319 511726 66648 79165695
Electrocardiogram U-wave abnormality 15.75 10.04 9 512036 87 79232256
Accidental exposure to product 15.74 10.04 127 511918 31195 79201148
Ileus 15.73 10.04 101 511944 26110 79206233
Endophthalmitis 15.73 10.04 11 512034 6417 79225926
Neurological decompensation 15.72 10.04 7 512038 5246 79227097
Haemolysis 15.70 10.04 37 512008 12775 79219568
Infective exacerbation of bronchiectasis 15.70 10.04 22 512023 752 79231591
Hilar lymphadenopathy 15.68 10.04 36 512009 1823 79230520
Burns third degree 15.68 10.04 17 512028 444 79231899
Colitis ulcerative 15.62 10.04 145 511900 34597 79197746
Anal fistula 15.57 10.04 13 512032 6931 79225412
Renal injury 15.56 10.04 56 511989 16871 79215472
Lip dry 15.54 10.04 49 511996 15369 79216974
Gingival bleeding 15.53 10.04 53 511992 16223 79216120
Self-injurious ideation 15.46 10.04 55 511990 3583 79228760
Wrist fracture 15.40 10.04 130 511915 11791 79220552
Diffuse large B-cell lymphoma recurrent 15.37 10.04 4 512041 4203 79228140
Haematoma 15.35 10.04 239 511806 51956 79180387
Exposure during pregnancy 15.23 10.04 514 511531 100618 79131725
Mycobacterial infection 15.20 10.04 55 511990 3613 79228730
Paraparesis 15.13 10.04 3 512042 3800 79228543
Cortisol decreased 15.05 10.04 39 512006 2133 79230210
Device ineffective 15.00 10.04 11 512034 168 79232175
Mood altered 14.99 10.04 178 511867 17669 79214674
Biliary dyskinesia 14.94 10.04 43 512002 2502 79229841
Diaphragmatic disorder 14.88 10.04 34 512011 1716 79230627
Nocardiosis 14.87 10.04 9 512036 5670 79226673
Product cleaning inadequate 14.84 10.04 5 512040 10 79232333
Granulocytopenia 14.84 10.04 32 512013 11399 79220944
Encephalitis 14.81 10.04 47 511998 14713 79217630
Hypoglycaemic coma 14.80 10.04 6 512039 4754 79227589
Cholangitis 14.79 10.04 38 512007 12738 79219605
Subileus 14.75 10.04 9 512036 5645 79226698
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.71 10.04 3 512042 3726 79228617
Neurosensory hypoacusis 14.62 10.04 12 512033 218 79232125
Sexual dysfunction 14.56 10.04 17 512028 7746 79224597
Bed bug infestation 14.53 10.04 5 512040 11 79232332
Cutaneous vasculitis 14.50 10.04 19 512026 8233 79224110
Hypoproteinaemia 14.50 10.04 4 512041 4042 79228301
Duodenal ulcer repair 14.48 10.04 8 512037 72 79232271
Decreased gait velocity 14.46 10.04 11 512034 178 79232165
Seronegative arthritis 14.45 10.04 6 512039 4686 79227657
Injection site reaction 14.43 10.04 256 511789 54529 79177814
Oesophageal pain 14.34 10.04 60 511985 4219 79228124
CFTR gene mutation 14.32 10.04 9 512036 105 79232238
Methaemoglobinaemia 14.29 10.04 9 512036 5548 79226795
Musculoskeletal disorder 14.27 10.04 80 511965 21368 79210975
Pneumonia respiratory syncytial viral 14.21 10.04 35 512010 1855 79230488
Brain scan abnormal 14.20 10.04 27 512018 1196 79231147
Cystic fibrosis lung 14.19 10.04 10 512035 143 79232200
Pleural effusion 14.19 10.04 775 511270 144487 79087856
Sinus polyp degeneration 14.14 10.04 7 512038 49 79232294
Medication error 14.13 10.04 334 511711 68308 79164035
Blood immunoglobulin E abnormal 14.10 10.04 6 512039 28 79232315
Pancreatitis 14.03 10.04 334 511711 68241 79164102
Clubbing 14.02 10.04 20 512025 695 79231648
Accidental death 14.02 10.04 5 512040 4286 79228057
Meningitis 14.01 10.04 25 512020 9557 79222786
Miosis 14.01 10.04 53 511992 15736 79216607
Cerebellar syndrome 13.92 10.04 9 512036 5471 79226872
Loss of consciousness 13.92 10.04 910 511135 167033 79065310
Oesophageal perforation 13.89 10.04 31 512014 1540 79230803
Thunderclap headache 13.89 10.04 15 512030 390 79231953
Ovarian hyperstimulation syndrome 13.83 10.04 3 512042 3568 79228775
Body temperature abnormal 13.82 10.04 40 512005 2335 79230008
Central nervous system lesion 13.82 10.04 42 512003 13326 79219017
Bronchial irritation 13.80 10.04 7 512038 52 79232291
Eye allergy 13.75 10.04 20 512025 708 79231635
Ill-defined disorder 13.71 10.04 320 511725 65555 79166788
Urinary tract infection 13.68 10.04 1548 510497 272964 78959379
Wound secretion 13.68 10.04 77 511968 6111 79226232
Tongue disorder 13.68 10.04 45 512000 13930 79218413
Mucosal discolouration 13.65 10.04 21 512024 782 79231561
Angioedema 13.63 10.04 608 511437 75427 79156916
Muscle spasms 13.61 10.04 1301 510744 173429 79058914
Varicella zoster gastritis 13.61 10.04 6 512039 31 79232312
Concussion 13.56 10.04 106 511939 9397 79222946
Hepatitis fulminant 13.52 10.04 16 512029 7246 79225097
Renal tubular disorder 13.51 10.04 13 512032 6473 79225870
Hyperventilation 13.51 10.04 92 511953 7807 79224536
Squamous cell carcinoma 13.50 10.04 53 511992 15569 79216774
Monoparesis 13.49 10.04 3 512042 3508 79228835
Cerebral artery thrombosis 13.49 10.04 25 512020 1086 79231257
Kyphosis 13.48 10.04 43 512002 2648 79229695
Meningitis cryptococcal 13.47 10.04 3 512042 3503 79228840
Guillain-Barre syndrome 13.47 10.04 23 512022 8942 79223401
Upper respiratory tract congestion 13.41 10.04 42 512003 2561 79229782
Aphasia 13.40 10.04 215 511830 46517 79185826
Colon cancer 13.38 10.04 48 511997 14475 79217868
Expiratory reserve volume decreased 13.36 10.04 8 512037 85 79232258
Finger deformity 13.35 10.04 17 512028 7457 79224886
Sinus bradycardia 13.33 10.04 101 511944 25146 79207197
FEV1/FVC ratio abnormal 13.31 10.04 6 512039 33 79232310
Bladder prolapse 13.30 10.04 29 512016 1418 79230925
Vaccination site erythema 13.28 10.04 8 512037 86 79232257
Choking sensation 13.27 10.04 55 511990 3851 79228492
Joint effusion 13.21 10.04 65 511980 17949 79214394
Expired product administered 13.19 10.04 84 511961 6967 79225376
Nonspecific reaction 13.18 10.04 41 512004 2491 79229852
Hysterectomy 13.18 10.04 77 511968 6195 79226148
Hyperhidrosis 13.17 10.04 1137 510908 150355 79081988
Dysarthria 13.11 10.04 332 511713 67290 79165053
Orthopnoea 13.10 10.04 110 511935 9963 79222380
Lymphocyte count decreased 13.09 10.04 219 511826 47070 79185273
Oral pruritus 13.08 10.04 40 512005 2408 79229935
Peritonitis bacterial 13.08 10.04 26 512019 9541 79222802
Bone cyst 13.06 10.04 3 512042 3430 79228913
Autoimmune haemolytic anaemia 13.05 10.04 21 512024 8359 79223984
Plasma cell myeloma 13.05 10.04 252 511793 53007 79179336
Blood potassium decreased 13.01 10.04 391 511654 46121 79186222
Adverse reaction 13.00 10.04 25 512020 9289 79223054
Proctalgia 12.98 10.04 28 512017 9973 79222370
Pneumonectomy 12.97 10.04 8 512037 90 79232253
Coordination abnormal 12.97 10.04 62 511983 17250 79215093
Prescription drug used without a prescription 12.94 10.04 5 512040 4080 79228263
Device expulsion 12.93 10.04 105 511940 25756 79206587
Lymphocytosis 12.92 10.04 7 512038 4686 79227657
Vertigo 12.91 10.04 341 511704 68741 79163602
Rectal haemorrhage 12.88 10.04 382 511663 75918 79156425
Ankylosing spondylitis 12.87 10.04 38 512007 12167 79220176
Cardiac tamponade 12.86 10.04 25 512020 9251 79223092
Type 2 diabetes mellitus 12.84 10.04 468 511577 56654 79175689
Acute lymphocytic leukaemia 12.84 10.04 8 512037 4961 79227382
Pneumonia cytomegaloviral 12.84 10.04 8 512037 4961 79227382
Accessory spleen 12.82 10.04 11 512034 213 79232130
Hepatocellular carcinoma 12.78 10.04 24 512021 8997 79223346
Leukocytosis 12.77 10.04 199 511846 43256 79189087
Social avoidant behaviour 12.77 10.04 63 511982 4751 79227592
Lung hernia 12.76 10.04 7 512038 62 79232281
Bacterial tracheitis 12.76 10.04 7 512038 62 79232281
Foetal death 12.76 10.04 92 511953 7952 79224391
Right ventricular systolic pressure 12.76 10.04 5 512040 18 79232325
Sputum culture 12.73 10.04 11 512034 215 79232128
Intestinal perforation 12.71 10.04 63 511982 17363 79214980
Dizziness exertional 12.68 10.04 17 512028 557 79231786
Urinary retention 12.67 10.04 272 511773 56358 79175985
Catatonia 12.67 10.04 23 512022 8733 79223610
Oropharyngeal candidiasis 12.64 10.04 32 512013 1725 79230618
Grunting 12.62 10.04 15 512030 434 79231909
Escherichia sepsis 12.62 10.04 22 512023 8486 79223857
Vaccination site warmth 12.59 10.04 4 512041 6 79232337
Dysphemia 12.59 10.04 50 511995 3434 79228909
Peripheral venous disease 12.49 10.04 56 511989 15853 79216490
Aortic aneurysm 12.49 10.04 95 511950 8351 79223992
Postural orthostatic tachycardia syndrome 12.49 10.04 22 512023 918 79231425
Blood lactic acid increased 12.48 10.04 131 511914 12613 79219730
Flail chest 12.46 10.04 8 512037 97 79232246
Pneumonia viral 12.44 10.04 101 511944 9057 79223286
Alcohol interaction 12.38 10.04 8 512037 4866 79227477
Radioallergosorbent test positive 12.36 10.04 6 512039 40 79232303
Coronary artery stenosis 12.36 10.04 40 512005 12444 79219899
Flour sensitivity 12.35 10.04 5 512040 20 79232323
Panic reaction 12.34 10.04 61 511984 4604 79227739
Endocrine ophthalmopathy 12.32 10.04 19 512026 709 79231634
Cardiac septal defect 12.31 10.04 13 512032 329 79232014
Retinal artery occlusion 12.29 10.04 3 512042 3291 79229052
Chest injury 12.29 10.04 43 512002 2778 79229565
Cholecystectomy 12.26 10.04 103 511942 9329 79223014
Acute sinusitis 12.26 10.04 60 511985 4510 79227833
Paresis 12.26 10.04 6 512039 4255 79228088
Quarantine 12.24 10.04 6 512039 41 79232302
Product prescribing issue 12.24 10.04 55 511990 3990 79228353
Lower limb fracture 12.19 10.04 93 511952 23122 79209221
Bursitis 12.19 10.04 309 511736 35535 79196808
Breath sounds 12.18 10.04 9 512036 139 79232204
Noninfective bronchitis 12.16 10.04 3 512042 0 79232343
Pseudomembranous colitis 12.12 10.04 10 512035 5364 79226979
Abnormal clotting factor 12.12 10.04 10 512035 183 79232160
Capillary leak syndrome 12.12 10.04 5 512040 3920 79228423
Suicidal ideation 12.10 10.04 603 511442 75737 79156606
Herpes simplex 12.10 10.04 39 512006 12148 79220195
Nephrogenic systemic fibrosis 12.09 10.04 13 512032 6147 79226196
Systemic infection 12.08 10.04 28 512017 9724 79222619
Klebsiella sepsis 12.06 10.04 3 512042 3249 79229094
Haematuria 12.03 10.04 343 511702 68493 79163850
Hepatitis acute 12.03 10.04 55 511990 15487 79216856
Gastrointestinal perforation 11.99 10.04 13 512032 6124 79226219
Necrosis 11.97 10.04 27 512018 9466 79222877
Dermatitis exfoliative 11.94 10.04 33 512012 10796 79221547
Prothrombin time shortened 11.93 10.04 3 512042 3225 79229118
Myocarditis 11.92 10.04 86 511959 21647 79210696
Ventricular hyperkinesia 11.91 10.04 12 512033 287 79232056
Hypermetropia 11.87 10.04 15 512030 463 79231880
Purpura 11.85 10.04 75 511970 19452 79212891
Aortic dissection 11.83 10.04 6 512039 4169 79228174
Gout 11.81 10.04 224 511821 24525 79207818
Personal relationship issue 11.81 10.04 10 512035 190 79232153
Musculoskeletal discomfort 11.81 10.04 186 511859 19649 79212694
Viral mutation identified 11.77 10.04 5 512040 3853 79228490
Tendon calcification 11.76 10.04 9 512036 147 79232196
Bronchopulmonary dysplasia 11.74 10.04 11 512034 240 79232103
Oropharyngitis fungal 11.74 10.04 8 512037 108 79232235
Hydronephrosis 11.67 10.04 65 511980 17389 79214954
Analgesic drug level increased 11.66 10.04 3 512042 3175 79229168
Periorbital swelling 11.64 10.04 43 512002 2853 79229490
Herpes virus infection 11.62 10.04 17 512028 7032 79225311
Aptyalism 11.61 10.04 19 512026 746 79231597
Otitis media 11.59 10.04 73 511972 6033 79226310
Quadriparesis 11.58 10.04 4 512041 3497 79228846
Mitral valve thickening 11.57 10.04 14 512031 413 79231930
Hepatic fibrosis 11.57 10.04 18 512027 7262 79225081
Product administration error 11.57 10.04 277 511768 31569 79200774
Breath alcohol test positive 11.56 10.04 4 512041 9 79232334
Percussion test abnormal 11.56 10.04 6 512039 47 79232296
Enterovirus infection 11.53 10.04 33 512012 1914 79230429
Melaena 11.53 10.04 300 511745 60590 79171753
Drug tolerance 11.50 10.04 24 512021 8651 79223692
Lactose intolerance 11.46 10.04 37 512008 2293 79230050
Therapeutic response decreased 11.46 10.04 334 511711 66519 79165824
Bronchitis chronic 11.43 10.04 58 511987 4424 79227919
Acute coronary syndrome 11.41 10.04 84 511961 21049 79211294
Inspiratory capacity decreased 11.41 10.04 9 512036 154 79232189
Macular oedema 11.37 10.04 11 512034 5463 79226880
Rash pustular 11.36 10.04 36 512009 11275 79221068
Brain herniation 11.34 10.04 19 512026 7444 79224899
Upper limb fracture 11.28 10.04 170 511875 17797 79214546
Bronchitis haemophilus 11.27 10.04 4 512041 10 79232333
Coagulation factor deficiency 11.27 10.04 9 512036 157 79232186
COVID-19 11.26 10.04 1167 510878 156507 79075836
Electrocardiogram QT prolonged 11.24 10.04 470 511575 89916 79142427
Infusion site bruising 11.18 10.04 43 512002 2909 79229434
Tracheostomy malfunction 11.17 10.04 9 512036 159 79232184
Caesarean section 11.17 10.04 42 512003 12493 79219850
Oxygen saturation 11.14 10.04 12 512033 311 79232032
Dislocation of vertebra 11.13 10.04 21 512024 7859 79224484
Aortic valve stenosis 11.13 10.04 65 511980 5229 79227114
Proctitis 11.11 10.04 15 512030 6417 79225926
Tuberculin test positive 11.09 10.04 4 512041 3404 79228939
Hypoglycaemia 11.07 10.04 536 511509 101058 79131285
Deafness neurosensory 11.01 10.04 17 512028 6881 79225462
Perennial allergy 11.00 10.04 4 512041 11 79232332
Blebitis 11.00 10.04 4 512041 11 79232332
Stem cell transplant 10.99 10.04 5 512040 3699 79228644
Cerebrovascular accident 10.98 10.04 853 511192 154439 79077904
Incorrect dose administered by device 10.98 10.04 62 511983 4927 79227416
Emergency care examination 10.97 10.04 8 512037 121 79232222
Pathological fracture 10.97 10.04 33 512012 10504 79221839
Deep vein thrombosis postoperative 10.96 10.04 34 512011 10718 79221625
Peptic ulcer 10.95 10.04 73 511972 6150 79226193
Muscle tension dysphonia 10.89 10.04 9 512036 165 79232178
Live birth 10.86 10.04 73 511972 18671 79213672
Obesity 10.85 10.04 299 511746 34826 79197517
Adjusted calcium decreased 10.79 10.04 10 512035 215 79232128
Haemorrhage subcutaneous 10.78 10.04 9 512036 4800 79227543
Resuscitation 10.78 10.04 37 512008 2367 79229976
Febrile infection 10.76 10.04 4 512041 3342 79229001
Paraneoplastic rash 10.76 10.04 7 512038 87 79232256
Thoracic haemorrhage 10.75 10.04 10 512035 216 79232127
Device failure 10.75 10.04 73 511972 6188 79226155
Oxygen consumption decreased 10.74 10.04 14 512031 446 79231897
Underdose 10.72 10.04 149 511896 33002 79199341
Electrocardiogram QT shortened 10.72 10.04 10 512035 217 79232126
Gaze palsy 10.71 10.04 3 512042 3002 79229341
Scratch 10.70 10.04 91 511954 8272 79224071
Anal haemorrhage 10.69 10.04 7 512038 4227 79228116
Paraplegia 10.68 10.04 10 512035 5043 79227300
Essential hypertension 10.65 10.04 71 511974 5982 79226361
Gastrointestinal necrosis 10.64 10.04 12 512033 5553 79226790
Osteolysis 10.61 10.04 8 512037 4490 79227853
Drug level below therapeutic 10.60 10.04 30 512015 9740 79222603
Neoplasm recurrence 10.59 10.04 7 512038 4207 79228136
Trifascicular block 10.58 10.04 9 512036 172 79232171
Bradypnoea 10.57 10.04 14 512031 6038 79226305
Breast cancer recurrent 10.56 10.04 3 512042 2974 79229369
Nasal ulcer 10.54 10.04 34 512011 2106 79230237
Wall motion score index abnormal 10.54 10.04 9 512036 173 79232170
Nasal flaring 10.51 10.04 4 512041 13 79232330
Infantile haemangioma 10.51 10.04 4 512041 13 79232330
Central nervous system mass 10.50 10.04 9 512036 174 79232169
Dyskinesia oesophageal 10.50 10.04 6 512039 58 79232285
Red cell distribution width abnormal 10.49 10.04 10 512035 223 79232120
Tuberculosis 10.49 10.04 56 511989 15142 79217201
Communication disorder 10.48 10.04 53 511992 4037 79228306
Anal fissure 10.47 10.04 21 512024 7682 79224661
Airway peak pressure increased 10.46 10.04 12 512033 334 79232009
Pyelonephritis acute 10.45 10.04 14 512031 6009 79226334
Sinus headache 10.44 10.04 62 511983 5018 79227325
Hepatitis 10.43 10.04 275 511770 55452 79176891
Neuropsychiatric symptoms 10.42 10.04 26 512019 1389 79230954
Coagulation factor V level abnormal 10.41 10.04 6 512039 59 79232284
Hypervolaemia 10.40 10.04 353 511692 42337 79190006
Tobacco user 10.39 10.04 18 512027 741 79231602
JC virus infection 10.38 10.04 6 512039 3875 79228468
Ocular discomfort 10.36 10.04 61 511984 4922 79227421
Reversible cerebral vasoconstriction syndrome 10.35 10.04 43 512002 3014 79229329
Acute febrile neutrophilic dermatosis 10.33 10.04 6 512039 3866 79228477
Toxic shock syndrome 10.33 10.04 24 512021 1225 79231118
Pancreatitis acute 10.31 10.04 241 511804 49363 79182980
Staphylococcal sepsis 10.31 10.04 54 511991 14672 79217671
Hernia pain 10.29 10.04 14 512031 465 79231878
PO2 decreased 10.29 10.04 42 512003 2921 79229422
Emergency care 10.28 10.04 22 512023 1062 79231281
Patient isolation 10.24 10.04 6 512039 61 79232282
Respiratory tract infection bacterial 10.24 10.04 33 512012 2044 79230299
Infusion site rash 10.23 10.04 29 512016 1673 79230670
School refusal 10.22 10.04 5 512040 34 79232309
Cor pulmonale acute 10.18 10.04 17 512028 679 79231664
Pelvic pain 10.18 10.04 131 511914 13250 79219093
Gait deviation 10.16 10.04 6 512039 62 79232281
Cardiac failure chronic 10.13 10.04 37 512008 11098 79221245
Hypernatraemia 10.11 10.04 53 511992 14398 79217945
Intestinal haemorrhage 10.11 10.04 16 512029 6410 79225933
Upper airway resistance syndrome 10.10 10.04 3 512042 3 79232340
Vocal cord leukoplakia 10.10 10.04 3 512042 3 79232340
Tracheal mass 10.10 10.04 3 512042 3 79232340
Device use issue 10.09 10.04 40 512005 2744 79229599
Embolic stroke 10.08 10.04 22 512023 7804 79224539
Drug level above therapeutic 10.06 10.04 26 512019 8697 79223646
Splenomegaly 10.04 10.04 85 511960 20669 79211674

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03AK04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03CC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
FDA MoA N0000009922 Adrenergic beta2-Agonists
CHEBI has role CHEBI:35522 beta-adrenergic agonists
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D015149 Tocolytic Agents
FDA EPC N0000175779 beta2-Adrenergic Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchospasm indication 4386001
Acute exacerbation of asthma indication 708038006
Bronchospasm Prevention indication
Exercise-Induced Bronchospasm Prevention indication
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Ketoacidosis contraindication 56051008
Metabolic acidosis contraindication 59455009
Diabetes mellitus contraindication 73211009 DOID:9351
Paradoxical bronchospasm contraindication 102578005
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Myocardial ischemia contraindication 414795007 DOID:3393
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Immediate relief of bronchospasm and bronchoconstriction associated with reversible airway obstruction Indication

🐶 Veterinary products

ProductApplicantIngredients
Torpex Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.07 acidic
pKa2 9.46 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 90MCG BASE/INH;80MCG/INH AIRSUPRA ASTRAZENECA N214070 Jan. 10, 2023 RX AEROSOL, METERED INHALATION 9415009 May 28, 2030 AS-NEEDED TREATMENT OR PREVENTION OF BRONCHOCONSTRICTION AND REDUCTION OF THE RISK OF EXACERBATIONS IN PATIENTS WITH ASTHMA 18 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 90MCG BASE/INH;80MCG/INH AIRSUPRA ASTRAZENECA N214070 Jan. 10, 2023 RX AEROSOL, METERED INHALATION Jan. 10, 2026 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST Ki 5.95 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.61 PDSP
Beta-2 adrenergic receptor GPCR Kd 5.94 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.28 CHEMBL

External reference:

IDSource
4018796 VUID
N0000147099 NUI
D02147 KEGG_DRUG
51022-70-9 SECONDARY_CAS_RN
142153 RXNORM
C0001927 UMLSCUI
CHEBI:2549 CHEBI
68H PDB_CHEM_ID
CHEMBL714 ChEMBL_ID
DB01001 DRUGBANK_ID
CHEMBL1441059 ChEMBL_ID
CHEMBL1201026 ChEMBL_ID
2083 PUBCHEM_CID
558 IUPHAR_LIGAND_ID
372897005 SNOMEDCT_US
48474002 SNOMEDCT_US
91143003 SNOMEDCT_US
D000420 MESH_DESCRIPTOR_UI
2585 INN_ID
4018796 VANDF
4018797 VANDF
3007 MMSL
30960 MMSL
4143 MMSL
4144 MMSL
46702 MMSL
d00749 MMSL
QF8SVZ843E UNII
001814 NDDF
001815 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0742 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) ANDA 14 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0742 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) ANDA 14 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 26 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 26 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 26 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0254-1007 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0255 TABLET 2 mg ORAL ANDA 23 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0572 TABLET 4 mg ORAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6991 SOLUTION 0.63 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6991 SOLUTION 0.63 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6991 SOLUTION 0.63 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6992 SOLUTION 1.25 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6992 SOLUTION 1.25 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6992 SOLUTION 1.25 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-7057 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-7058 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-8270 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 24 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0378-9671 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0472-0825 SYRUP 2 mg ORAL ANDA 22 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0487-0201 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-0301 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9501 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9901 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9904 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3467 SOLUTION 0.63 mg INTRABRONCHIAL ANDA 23 sections