procaterol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 2273 72332-33-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • procaterol
  • (R,S)-Procaterol
  • (+/-)-Procaterol
A long-acting beta-2-adrenergic receptor agonist.
  • Molecular weight: 290.36
  • Formula: C16H22N2O3
  • CLOGP: 0.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 81.59
  • ALOGS: -2.95
  • ROTB: 5

Drug dosage:

DoseUnitRoute
60 mcg Inhal.aerosol
0.10 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 40 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AC16 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03CC08 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D013566 Sympathomimetics

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.58 acidic
pKa2 11.26 acidic
pKa3 9.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST EC50 8.43 IUPHAR IUPHAR

External reference:

IDSource
N0000166917 NUI
D08424 KEGG_DRUG
C0072032 UMLSCUI
CHEBI:135209 CHEBI
688563 PUBCHEM_CID
CHEMBL160519 ChEMBL_ID
D017265 MESH_DESCRIPTOR_UI
DB01366 DRUGBANK_ID
3464 IUPHAR_LIGAND_ID
4259 INN_ID
X7I3EMM5K0 UNII
34530 RXNORM
003878 NDDF
703566006 SNOMEDCT_US

Pharmaceutical products:

None