hexoprenaline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 1372 3215-70-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • delaprem
  • hexoprenaline
  • ipradol
  • hexoprenaline hydrochloride
  • hexoprenaline dihydrochloride
  • hexoprenaline sulfate
  • hexoprenaline HCl
Stimulant of adrenergic beta 2 receptors. It is used as a bronchodilator, antiasthmatic agent, and tocolytic agent.
  • Molecular weight: 420.51
  • Formula: C22H32N2O6
  • CLOGP: 0.05
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 8
  • TPSA: 145.44
  • ALOGS: -3.33
  • ROTB: 13

Drug dosage:

DoseUnitRoute
1.50 mg Inhal.aerosol
1.50 mg O
1.50 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK16,CDK19,CDK2,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FLT1,FLT3,FLT4,GRK2,GRK3,GSK3A,GSK3B,IGF1R,IKBKB,INSR,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K1,MAP3K10,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAP4K3,MAP4K5,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,SRC,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 103
kinase-selectivity-class ACVR2B,ACVRL1,AXL,CDK4,CDK9,DYRK1B,EIF2AK3,EPHB4,GRK2,INSR,MAP2K6,MAP3K14,MAPK7,MAPK8,PLK1,PLK2,PLK3,SIK2,STK33,SYK,TEK,TGFBR1 22
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AC06 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03CC05 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D001993 Bronchodilator Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D015149 Tocolytic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists

Related Drugs by ATC class:

R03AC Selective beta-2-adrenoreceptor agonists 17 drugs
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R03CC Selective beta-2-adrenoreceptor agonists 14 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.67 acidic
pKa2 10.27 acidic
pKa3 12.52 acidic
pKa4 13.12 acidic
pKa5 13.46 acidic
pKa6 9.2 Basic
pKa7 8.59 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000166518 NUI
D02396 KEGG_DRUG
C0019476 UMLSCUI
CHEMBL1589896 ChEMBL_ID
CHEMBL2104813 ChEMBL_ID
D006594 MESH_DESCRIPTOR_UI
DB08957 DRUGBANK_ID
3609 PUBCHEM_CID
2650 INN_ID
4323-43-7 SECONDARY_CAS_RN
32266-10-7 SECONDARY_CAS_RN
G9L6B3W684 UNII
258331 RXNORM
006635 NDDF
006636 NDDF
006637 NDDF
488371000221109 SNOMEDCT_US
704987001 SNOMEDCT_US
704988006 SNOMEDCT_US
CHEBI:37950 CHEBI
G9L6B3W684 INXIGHT DRUGS

Pharmaceutical products:

None