clenbuterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
bronchodilators, phenethylamine derivatives	673	37148-27-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clenbuterol
(RS)-Clenbuterol
(+/-)-Clenbuterol
planipart
dl-Clenbuterol
clenbuterol hydrochloride
clenbuterol HCl

A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.

Molecular weight: 277.19
Formula: C12H18Cl2N2O
CLOGP: 2.39
LIPINSKI: 0
HAC: 3
HDO: 3
TPSA: 58.28
ALOGS: -3.39
ROTB: 4

Drug dosage:

Dose	Unit	Route
40	mcg	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	4 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Secondary hypogonadism	67.81	54.26	9	378	360	79743641
Hyperthyroidism	59.43	54.26	15	372	22194	79721807

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03AC14	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists
ATC	R03CC13	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists
ATC	R03CC63	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D000318	Adrenergic beta-Agonists
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D013566	Sympathomimetics
CHEBI has role	CHEBI:35522	beta-adrenergic agonists
CHEBI has role	CHEBI:35523	bronchodilator
CHEBI has role	CHEBI:35524	sympathomimetic

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

Species	Use	Relation
Horses	Management of horses affected with airway obstruction	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Ventipulmin Syrup	Boehringer lngelheim Animal Health USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.08	Basic
pKa2	1.84	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		Ki	7.16		DRUG MATRIX
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Kd	7.80		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	5.82		DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		IC50	5.58		CHEMBL
Beta-2 adrenergic receptor	GPCR		ADRB2_BOVIN		Kd	7.44		CHEMBL

External reference:

ID	Source
N0000166810	NUI
D01360	KEGG_DRUG
235955	RXNORM
C0008932	UMLSCUI
CHEBI:174690	CHEBI
CHEMBL49080	ChEMBL_ID
DB01407	DRUGBANK_ID
D002976	MESH_DESCRIPTOR_UI
2783	PUBCHEM_CID
12582	IUPHAR_LIGAND_ID
3264	INN_ID
21898-19-1	SECONDARY_CAS_RN
XTZ6AXU7KN	UNII
004338	NDDF
004339	NDDF
418264008	SNOMEDCT_US
425138006	SNOMEDCT_US
CHEMBL1330729	ChEMBL_ID

Pharmaceutical products:

None