Stem definition | Drug id | CAS RN |
---|---|---|
bronchodilators, phenethylamine derivatives | 1239 | 73573-87-2 |
Dose | Unit | Route |
---|---|---|
24 | mcg | Inhal.aerosol |
24 | mcg | Inhal.powder |
0.16 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.66 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 8 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.00 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 16, 2001 | FDA | NOVARTIS | |
June 18, 2019 | PMDA | AstraZeneca K.K. | |
April 28, 2014 | EMA | Teva Pharma B.V. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 978.79 | 13.40 | 655 | 29187 | 112115 | 56150110 |
Product quality issue | 649.81 | 13.40 | 323 | 29519 | 31413 | 56230812 |
Dyspnoea | 486.00 | 13.40 | 1005 | 28837 | 591572 | 55670653 |
Wheezing | 332.97 | 13.40 | 293 | 29549 | 74733 | 56187492 |
Chronic obstructive pulmonary disease | 262.21 | 13.40 | 228 | 29614 | 57187 | 56205038 |
Obstructive airways disorder | 253.91 | 13.40 | 141 | 29701 | 17141 | 56245084 |
Cough | 231.59 | 13.40 | 458 | 29384 | 259503 | 56002722 |
No adverse event | 169.11 | 13.40 | 146 | 29696 | 36228 | 56225997 |
Chest discomfort | 169.09 | 13.40 | 234 | 29608 | 98623 | 56163602 |
Polycystic ovaries | 150.14 | 13.40 | 59 | 29783 | 3255 | 56258970 |
Sleep apnoea syndrome | 138.46 | 13.40 | 113 | 29729 | 25948 | 56236277 |
Nasal polyps | 137.01 | 13.40 | 55 | 29787 | 3210 | 56259015 |
Product dose omission issue | 122.44 | 13.40 | 308 | 29534 | 204445 | 56057780 |
Gastrooesophageal reflux disease | 118.88 | 13.40 | 181 | 29661 | 83076 | 56179149 |
Emphysema | 118.76 | 13.40 | 71 | 29771 | 9905 | 56252320 |
Productive cough | 105.02 | 13.40 | 139 | 29703 | 56093 | 56206132 |
Sputum increased | 103.96 | 13.40 | 40 | 29802 | 2084 | 56260141 |
Rheumatoid arthritis | 103.34 | 13.40 | 37 | 29805 | 382567 | 55879658 |
Salpingo-oophorectomy unilateral | 98.11 | 13.40 | 29 | 29813 | 663 | 56261562 |
Sinusitis fungal | 93.41 | 13.40 | 34 | 29808 | 1516 | 56260709 |
Respiratory symptom | 90.12 | 13.40 | 39 | 29803 | 2751 | 56259474 |
Candida infection | 89.98 | 13.40 | 88 | 29754 | 25579 | 56236646 |
Rhinitis allergic | 89.82 | 13.40 | 56 | 29786 | 8418 | 56253807 |
Sensitisation | 86.10 | 13.40 | 36 | 29806 | 2332 | 56259893 |
Off label use | 85.20 | 13.40 | 102 | 29740 | 556078 | 55706147 |
Asthmatic crisis | 82.97 | 13.40 | 32 | 29810 | 1678 | 56260547 |
Embolism venous | 82.89 | 13.40 | 37 | 29805 | 2811 | 56259414 |
Ejection fraction | 82.88 | 13.40 | 32 | 29810 | 1683 | 56260542 |
Eosinophilic granulomatosis with polyangiitis | 80.57 | 13.40 | 33 | 29809 | 2028 | 56260197 |
Eczema | 79.47 | 13.40 | 83 | 29759 | 26070 | 56236155 |
Systemic lupus erythematosus | 78.92 | 13.40 | 4 | 29838 | 180074 | 56082151 |
Hyper IgE syndrome | 78.47 | 13.40 | 22 | 29820 | 414 | 56261811 |
Skin candida | 78.14 | 13.40 | 29 | 29813 | 1367 | 56260858 |
Blood test abnormal | 75.50 | 13.40 | 59 | 29783 | 12725 | 56249500 |
Joint swelling | 70.12 | 13.40 | 33 | 29809 | 289767 | 55972458 |
Dysphonia | 68.21 | 13.40 | 97 | 29745 | 41850 | 56220375 |
Female genital tract fistula | 66.90 | 13.40 | 37 | 29805 | 4455 | 56257770 |
Bronchospasm | 65.02 | 13.40 | 59 | 29783 | 15610 | 56246615 |
Mycobacterium avium complex infection | 63.99 | 13.40 | 31 | 29811 | 2838 | 56259387 |
Treatment failure | 63.05 | 13.40 | 8 | 29834 | 170384 | 56091841 |
Restrictive pulmonary disease | 61.59 | 13.40 | 25 | 29817 | 1501 | 56260724 |
Alopecia | 60.12 | 13.40 | 41 | 29801 | 293417 | 55968808 |
Arthropathy | 60.03 | 13.40 | 16 | 29826 | 200259 | 56061966 |
Diastolic dysfunction | 59.06 | 13.40 | 37 | 29805 | 5608 | 56256617 |
Drug intolerance | 58.36 | 13.40 | 34 | 29808 | 264784 | 55997441 |
Dyspnoea exertional | 57.93 | 13.40 | 104 | 29738 | 54585 | 56207640 |
Sputum discoloured | 57.71 | 13.40 | 53 | 29789 | 14239 | 56247986 |
Hepatic enzyme increased | 54.67 | 13.40 | 12 | 29830 | 171372 | 56090853 |
Chronic sinusitis | 54.59 | 13.40 | 41 | 29801 | 8337 | 56253888 |
Toxicity to various agents | 53.64 | 13.40 | 26 | 29816 | 224538 | 56037687 |
Pain | 52.93 | 13.40 | 178 | 29664 | 663006 | 55599219 |
Pneumonia | 51.83 | 13.40 | 381 | 29461 | 406717 | 55855508 |
Pulmonary mass | 51.79 | 13.40 | 59 | 29783 | 20411 | 56241814 |
Diverticulum | 50.55 | 13.40 | 44 | 29798 | 11022 | 56251203 |
Oedema peripheral | 48.95 | 13.40 | 200 | 29642 | 171054 | 56091171 |
Hypothyroidism | 48.85 | 13.40 | 79 | 29763 | 38117 | 56224108 |
Hiatus hernia | 48.63 | 13.40 | 56 | 29786 | 19596 | 56242629 |
Sleep disorder due to a general medical condition | 47.39 | 13.40 | 39 | 29803 | 9051 | 56253174 |
Bronchiectasis | 47.33 | 13.40 | 43 | 29799 | 11391 | 56250834 |
Product use issue | 45.24 | 13.40 | 21 | 29821 | 186020 | 56076205 |
Product container issue | 44.87 | 13.40 | 20 | 29822 | 1514 | 56260711 |
Abdominal discomfort | 44.32 | 13.40 | 49 | 29793 | 277225 | 55985000 |
Neurosensory hypoacusis | 43.35 | 13.40 | 12 | 29830 | 215 | 56262010 |
Pericarditis | 43.11 | 13.40 | 4 | 29838 | 108919 | 56153306 |
Infusion related reaction | 43.01 | 13.40 | 29 | 29813 | 208902 | 56053323 |
Nephrectomy | 42.62 | 13.40 | 18 | 29824 | 1195 | 56261030 |
Pulmonary function test decreased | 41.29 | 13.40 | 25 | 29817 | 3566 | 56258659 |
Tricuspid valve incompetence | 40.15 | 13.40 | 42 | 29800 | 13211 | 56249014 |
Swelling | 39.84 | 13.40 | 41 | 29801 | 239730 | 56022495 |
White blood cell count decreased | 39.81 | 13.40 | 9 | 29833 | 125981 | 56136244 |
Arthralgia | 39.70 | 13.40 | 135 | 29707 | 501534 | 55760691 |
Hysterectomy | 38.92 | 13.40 | 34 | 29808 | 8557 | 56253668 |
Full blood count abnormal | 36.97 | 13.40 | 57 | 29785 | 26405 | 56235820 |
Facial nerve disorder | 36.55 | 13.40 | 13 | 29829 | 542 | 56261683 |
Intentional product use issue | 36.12 | 13.40 | 5 | 29837 | 99728 | 56162497 |
CFTR gene mutation | 36.09 | 13.40 | 9 | 29833 | 105 | 56262120 |
Iron deficiency anaemia | 36.08 | 13.40 | 46 | 29796 | 17873 | 56244352 |
Rhinitis | 35.87 | 13.40 | 33 | 29809 | 8883 | 56253342 |
Glossodynia | 35.86 | 13.40 | 18 | 29824 | 152440 | 56109785 |
Musculoskeletal stiffness | 35.83 | 13.40 | 19 | 29823 | 155988 | 56106237 |
Drug ineffective | 35.77 | 13.40 | 314 | 29528 | 918675 | 55343550 |
Fatigue | 35.47 | 13.40 | 259 | 29583 | 788293 | 55473932 |
Feeling jittery | 34.40 | 13.40 | 37 | 29805 | 12009 | 56250216 |
Peripheral swelling | 33.77 | 13.40 | 45 | 29797 | 234681 | 56027544 |
Burning sensation | 33.01 | 13.40 | 77 | 29765 | 48619 | 56213606 |
Discomfort | 32.94 | 13.40 | 17 | 29825 | 141744 | 56120481 |
Therapeutic product effect decreased | 32.93 | 13.40 | 25 | 29817 | 169427 | 56092798 |
Product taste abnormal | 32.16 | 13.40 | 17 | 29825 | 1871 | 56260354 |
Pulmonary embolism | 32.09 | 13.40 | 127 | 29715 | 106997 | 56155228 |
Heart rate increased | 31.94 | 13.40 | 107 | 29735 | 83166 | 56179059 |
Lipohypertrophy | 31.43 | 13.40 | 12 | 29830 | 612 | 56261613 |
Respiratory tract infection | 31.27 | 13.40 | 63 | 29779 | 36008 | 56226217 |
Transient ischaemic attack | 30.74 | 13.40 | 60 | 29782 | 33517 | 56228708 |
Dyslipidaemia | 30.52 | 13.40 | 26 | 29816 | 6327 | 56255898 |
Bronchopulmonary aspergillosis allergic | 30.38 | 13.40 | 15 | 29827 | 1431 | 56260794 |
Pulmonary congestion | 30.31 | 13.40 | 40 | 29802 | 16075 | 56246150 |
Urinary tract discomfort | 30.26 | 13.40 | 10 | 29832 | 333 | 56261892 |
Drug hypersensitivity | 29.27 | 13.40 | 64 | 29778 | 275141 | 55987084 |
Increased bronchial secretion | 28.88 | 13.40 | 15 | 29827 | 1592 | 56260633 |
Febrile neutropenia | 28.77 | 13.40 | 10 | 29832 | 105535 | 56156690 |
Peak expiratory flow rate decreased | 28.05 | 13.40 | 11 | 29831 | 603 | 56261622 |
Impaired healing | 27.84 | 13.40 | 6 | 29836 | 86835 | 56175390 |
Congenital naevus | 27.27 | 13.40 | 8 | 29834 | 178 | 56262047 |
Bronchitis chronic | 27.06 | 13.40 | 20 | 29822 | 3968 | 56258257 |
Throat tightness | 26.83 | 13.40 | 45 | 29797 | 22362 | 56239863 |
Peripheral vascular disorder | 26.62 | 13.40 | 23 | 29819 | 5702 | 56256523 |
Oropharyngeal pain | 26.44 | 13.40 | 101 | 29741 | 83687 | 56178538 |
Swollen tongue | 26.33 | 13.40 | 53 | 29789 | 30271 | 56231954 |
Blood electrolytes abnormal | 26.13 | 13.40 | 12 | 29830 | 974 | 56261251 |
Nervous system disorder | 25.90 | 13.40 | 38 | 29804 | 16851 | 56245374 |
Limb injury | 25.71 | 13.40 | 44 | 29798 | 22226 | 56239999 |
Increased upper airway secretion | 25.69 | 13.40 | 18 | 29824 | 3286 | 56258939 |
Osteoporosis | 25.65 | 13.40 | 73 | 29769 | 51979 | 56210246 |
Angioplasty | 25.58 | 13.40 | 13 | 29829 | 1319 | 56260906 |
Skin lesion | 25.42 | 13.40 | 50 | 29792 | 28085 | 56234140 |
Diarrhoea | 25.26 | 13.40 | 217 | 29625 | 638290 | 55623935 |
Cardiac disorder | 25.24 | 13.40 | 67 | 29775 | 45820 | 56216405 |
Alveolar osteitis | 25.21 | 13.40 | 10 | 29832 | 565 | 56261660 |
Breast neoplasm | 25.18 | 13.40 | 13 | 29829 | 1363 | 56260862 |
Underdose | 24.92 | 13.40 | 45 | 29797 | 23712 | 56238513 |
Throat irritation | 24.73 | 13.40 | 54 | 29788 | 32629 | 56229596 |
Anaphylactic reaction | 24.60 | 13.40 | 78 | 29764 | 58917 | 56203308 |
Coronary artery disease | 24.59 | 13.40 | 52 | 29790 | 30744 | 56231481 |
Breath sounds abnormal | 24.56 | 13.40 | 27 | 29815 | 8980 | 56253245 |
Hypomagnesaemia | 24.49 | 13.40 | 46 | 29796 | 24969 | 56237256 |
Incorrect dose administered | 24.26 | 13.40 | 72 | 29770 | 52475 | 56209750 |
Psoriatic arthropathy | 23.95 | 13.40 | 5 | 29837 | 74003 | 56188222 |
Drug abuse | 23.09 | 13.40 | 4 | 29838 | 67606 | 56194619 |
Circumstance or information capable of leading to medication error | 22.74 | 13.40 | 17 | 29825 | 3431 | 56258794 |
Infection | 22.59 | 13.40 | 45 | 29797 | 200161 | 56062064 |
Carpal tunnel syndrome | 22.48 | 13.40 | 37 | 29805 | 18107 | 56244118 |
Therapy partial responder | 22.39 | 13.40 | 24 | 29818 | 7761 | 56254464 |
Lung neoplasm malignant | 22.26 | 13.40 | 36 | 29806 | 17360 | 56244865 |
Pharyngeal oedema | 21.99 | 13.40 | 31 | 29811 | 13254 | 56248971 |
Female reproductive neoplasm | 21.98 | 13.40 | 5 | 29837 | 38 | 56262187 |
Middle insomnia | 21.87 | 13.40 | 28 | 29814 | 10922 | 56251303 |
Hypertension | 21.62 | 13.40 | 211 | 29631 | 244067 | 56018158 |
Tunnel vision | 21.48 | 13.40 | 10 | 29832 | 837 | 56261388 |
Choking | 21.19 | 13.40 | 25 | 29817 | 8972 | 56253253 |
Disease recurrence | 21.07 | 13.40 | 42 | 29800 | 23818 | 56238407 |
Palpitations | 20.68 | 13.40 | 106 | 29736 | 99566 | 56162659 |
Bronchitis | 20.30 | 13.40 | 115 | 29727 | 112196 | 56150029 |
Allergic sinusitis | 20.28 | 13.40 | 9 | 29833 | 674 | 56261551 |
Renal disorder | 20.26 | 13.40 | 47 | 29795 | 29558 | 56232667 |
Neutropenic sepsis | 20.22 | 13.40 | 32 | 29810 | 15153 | 56247072 |
Device malfunction | 20.12 | 13.40 | 33 | 29809 | 16103 | 56246122 |
Fungal infection | 20.03 | 13.40 | 50 | 29792 | 32943 | 56229282 |
Disease progression | 19.81 | 13.40 | 16 | 29826 | 105157 | 56157068 |
Ear congestion | 19.65 | 13.40 | 13 | 29829 | 2162 | 56260063 |
Carnitine deficiency | 19.64 | 13.40 | 6 | 29836 | 154 | 56262071 |
Bordetella test positive | 19.63 | 13.40 | 3 | 29839 | 0 | 56262225 |
Animal scratch | 19.28 | 13.40 | 10 | 29832 | 1058 | 56261167 |
Ejection fraction abnormal | 19.00 | 13.40 | 10 | 29832 | 1090 | 56261135 |
Kyphosis | 18.98 | 13.40 | 13 | 29829 | 2289 | 56259936 |
Restless legs syndrome | 18.93 | 13.40 | 33 | 29809 | 16914 | 56245311 |
Psoriasis | 18.87 | 13.40 | 13 | 29829 | 92679 | 56169546 |
Infective exacerbation of chronic obstructive airways disease | 18.83 | 13.40 | 10 | 29832 | 1111 | 56261114 |
Lip pruritus | 18.78 | 13.40 | 9 | 29833 | 804 | 56261421 |
Macrocytosis | 18.66 | 13.40 | 13 | 29829 | 2353 | 56259872 |
Device ineffective | 18.47 | 13.40 | 6 | 29836 | 189 | 56262036 |
Pancreatitis relapsing | 18.37 | 13.40 | 9 | 29833 | 844 | 56261381 |
Respiratory tract congestion | 18.25 | 13.40 | 31 | 29811 | 15560 | 56246665 |
Oligohydramnios | 18.16 | 13.40 | 19 | 29823 | 5975 | 56256250 |
Foreign body aspiration | 18.03 | 13.40 | 6 | 29836 | 204 | 56262021 |
Intentional overdose | 17.64 | 13.40 | 7 | 29835 | 68110 | 56194115 |
Spirometry abnormal | 17.42 | 13.40 | 6 | 29836 | 227 | 56261998 |
Tubulointerstitial nephritis and uveitis syndrome | 17.37 | 13.40 | 6 | 29836 | 229 | 56261996 |
Condition aggravated | 17.04 | 13.40 | 110 | 29732 | 344788 | 55917437 |
Deep vein thrombosis | 16.77 | 13.40 | 83 | 29759 | 76894 | 56185331 |
Depression | 16.62 | 13.40 | 157 | 29685 | 179960 | 56082265 |
Oedema mouth | 16.61 | 13.40 | 12 | 29830 | 2298 | 56259927 |
Bladder pain | 16.55 | 13.40 | 11 | 29831 | 1843 | 56260382 |
Stomatitis | 16.52 | 13.40 | 24 | 29818 | 120786 | 56141439 |
Urinary retention | 16.47 | 13.40 | 42 | 29800 | 28032 | 56234193 |
Forced expiratory volume decreased | 16.37 | 13.40 | 16 | 29826 | 4644 | 56257581 |
Mobility decreased | 16.34 | 13.40 | 17 | 29825 | 98974 | 56163251 |
Dysphagia | 16.20 | 13.40 | 86 | 29756 | 81861 | 56180364 |
Respiratory disorder | 16.12 | 13.40 | 47 | 29795 | 33910 | 56228315 |
Rales | 16.06 | 13.40 | 24 | 29818 | 10816 | 56251409 |
Myocardial infarction | 16.06 | 13.40 | 94 | 29748 | 92776 | 56169449 |
Blood immunoglobulin E increased | 15.87 | 13.40 | 13 | 29829 | 2996 | 56259229 |
Gastrointestinal disorder | 15.79 | 13.40 | 22 | 29820 | 112680 | 56149545 |
Crepitations | 15.78 | 13.40 | 19 | 29823 | 6965 | 56255260 |
Hypotension | 15.59 | 13.40 | 74 | 29768 | 250434 | 56011791 |
Malignant neoplasm progression | 15.41 | 13.40 | 10 | 29832 | 73577 | 56188648 |
Abscess | 15.10 | 13.40 | 28 | 29814 | 15053 | 56247172 |
Eosinophilia | 14.99 | 13.40 | 33 | 29809 | 20044 | 56242181 |
Haemoptysis | 14.82 | 13.40 | 39 | 29803 | 26521 | 56235704 |
Irritable bowel syndrome | 14.76 | 13.40 | 9 | 29833 | 68449 | 56193776 |
Blister | 14.52 | 13.40 | 22 | 29820 | 108865 | 56153360 |
Presbyacusis | 14.42 | 13.40 | 12 | 29830 | 2826 | 56259399 |
Neutropenia | 14.28 | 13.40 | 40 | 29802 | 158127 | 56104098 |
Mouth ulceration | 14.05 | 13.40 | 41 | 29801 | 29599 | 56232626 |
Haemorrhage | 13.87 | 13.40 | 63 | 29779 | 56334 | 56205891 |
Hypoaesthesia oral | 13.74 | 13.40 | 23 | 29819 | 11408 | 56250817 |
Platelet count decreased | 13.71 | 13.40 | 22 | 29820 | 106361 | 56155864 |
Left ventricular hypertrophy | 13.69 | 13.40 | 15 | 29827 | 4969 | 56257256 |
Nasal inflammation | 13.60 | 13.40 | 6 | 29836 | 443 | 56261782 |
Long QT syndrome | 13.58 | 13.40 | 12 | 29830 | 3064 | 56259161 |
Polymyalgia rheumatica | 13.56 | 13.40 | 12 | 29830 | 3070 | 56259155 |
Plasma cell myeloma | 13.45 | 13.40 | 4 | 29838 | 46642 | 56215583 |
Wound complication | 13.41 | 13.40 | 12 | 29830 | 3116 | 56259109 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 553.03 | 13.67 | 317 | 16068 | 42294 | 31638665 |
Product quality issue | 407.28 | 13.67 | 188 | 16197 | 15923 | 31665036 |
Chronic obstructive pulmonary disease | 293.53 | 13.67 | 218 | 16167 | 44948 | 31636011 |
Dyspnoea | 271.25 | 13.67 | 565 | 15820 | 342914 | 31338045 |
No adverse event | 157.88 | 13.67 | 108 | 16277 | 19517 | 31661442 |
Nasal obstruction | 155.81 | 13.67 | 40 | 16345 | 544 | 31680415 |
Wheezing | 147.63 | 13.67 | 133 | 16252 | 35853 | 31645106 |
Sinus pain | 117.85 | 13.67 | 33 | 16352 | 635 | 31680324 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 106.65 | 13.67 | 33 | 16352 | 909 | 31680050 |
Eosinophilic granulomatosis with polyangiitis | 92.58 | 13.67 | 34 | 16351 | 1597 | 31679362 |
Emphysema | 91.04 | 13.67 | 57 | 16328 | 8861 | 31672098 |
Cough | 89.73 | 13.67 | 208 | 16177 | 134606 | 31546353 |
Pulmonary function test decreased | 85.86 | 13.67 | 43 | 16342 | 4342 | 31676617 |
Throat irritation | 79.01 | 13.67 | 53 | 16332 | 9261 | 31671698 |
Mycobacterium avium complex infection | 76.20 | 13.67 | 33 | 16352 | 2393 | 31678566 |
Product dose omission issue | 71.38 | 13.67 | 164 | 16221 | 105422 | 31575537 |
Bronchiectasis | 71.27 | 13.67 | 46 | 16339 | 7534 | 31673425 |
Chest discomfort | 67.82 | 13.67 | 104 | 16281 | 49265 | 31631694 |
Sputum discoloured | 63.41 | 13.67 | 41 | 16344 | 6735 | 31674224 |
Hepatic vein dilatation | 62.42 | 13.67 | 16 | 16369 | 216 | 31680743 |
Eosinophil count | 60.50 | 13.67 | 14 | 16371 | 119 | 31680840 |
Respiratory disorder | 59.63 | 13.67 | 59 | 16326 | 17841 | 31663118 |
Vocal cord dysfunction | 57.76 | 13.67 | 14 | 16371 | 148 | 31680811 |
Osteopenia | 54.43 | 13.67 | 32 | 16353 | 4439 | 31676520 |
Liver palpable | 54.09 | 13.67 | 15 | 16370 | 278 | 31680681 |
Lung consolidation | 50.92 | 13.67 | 33 | 16352 | 5440 | 31675519 |
Suffocation feeling | 48.86 | 13.67 | 16 | 16369 | 531 | 31680428 |
Obstructive airways disorder | 48.34 | 13.67 | 45 | 16340 | 12619 | 31668340 |
Atrial enlargement | 46.91 | 13.67 | 14 | 16371 | 340 | 31680619 |
Toxicity to various agents | 44.65 | 13.67 | 19 | 16366 | 181468 | 31499491 |
Ventricular enlargement | 43.18 | 13.67 | 14 | 16371 | 450 | 31680509 |
Nasal congestion | 41.61 | 13.67 | 52 | 16333 | 20329 | 31660630 |
Inferior vena cava dilatation | 41.55 | 13.67 | 15 | 16370 | 670 | 31680289 |
Pulmonary mass | 40.90 | 13.67 | 39 | 16346 | 11267 | 31669692 |
Hangover | 39.68 | 13.67 | 16 | 16369 | 969 | 31679990 |
Dyspnoea at rest | 39.67 | 13.67 | 24 | 16361 | 3507 | 31677452 |
Panic reaction | 37.72 | 13.67 | 17 | 16368 | 1355 | 31679604 |
Sputum increased | 36.10 | 13.67 | 19 | 16366 | 2126 | 31678833 |
Sleep disorder due to a general medical condition | 35.01 | 13.67 | 23 | 16362 | 3879 | 31677080 |
Chest pain | 33.27 | 13.67 | 134 | 16251 | 116823 | 31564136 |
Bronchial hyperreactivity | 30.75 | 13.67 | 15 | 16370 | 1430 | 31679529 |
Bronchial obstruction | 30.60 | 13.67 | 15 | 16370 | 1445 | 31679514 |
Bronchospasm | 29.79 | 13.67 | 31 | 16354 | 9941 | 31671018 |
Full blood count abnormal | 29.13 | 13.67 | 39 | 16346 | 16308 | 31664651 |
Forced expiratory volume decreased | 27.82 | 13.67 | 18 | 16367 | 2959 | 31678000 |
Toxic neuropathy | 26.61 | 13.67 | 10 | 16375 | 501 | 31680458 |
Stridor | 26.49 | 13.67 | 16 | 16369 | 2331 | 31678628 |
Fungal oesophagitis | 26.40 | 13.67 | 9 | 16376 | 339 | 31680620 |
Weaning failure | 25.43 | 13.67 | 8 | 16377 | 233 | 31680726 |
Product prescribing error | 25.02 | 13.67 | 40 | 16345 | 19602 | 31661357 |
Product container issue | 24.64 | 13.67 | 10 | 16375 | 616 | 31680343 |
Foreign body aspiration | 24.07 | 13.67 | 7 | 16378 | 155 | 31680804 |
Oedema mouth | 23.96 | 13.67 | 12 | 16373 | 1211 | 31679748 |
Underdose | 23.88 | 13.67 | 31 | 16354 | 12576 | 31668383 |
Heart rate irregular | 23.80 | 13.67 | 33 | 16352 | 14256 | 31666703 |
Drug abuse | 23.52 | 13.67 | 8 | 16377 | 87750 | 31593209 |
Platelet count decreased | 23.47 | 13.67 | 14 | 16371 | 110421 | 31570538 |
Nasal polyps | 23.44 | 13.67 | 14 | 16371 | 1999 | 31678960 |
Pneumonia | 23.29 | 13.67 | 270 | 16115 | 335042 | 31345917 |
Rales | 22.54 | 13.67 | 25 | 16360 | 8614 | 31672345 |
Palpitations | 22.52 | 13.67 | 53 | 16332 | 34530 | 31646429 |
Oedema | 22.24 | 13.67 | 60 | 16325 | 42501 | 31638458 |
Neutropenia | 22.08 | 13.67 | 24 | 16361 | 140340 | 31540619 |
Respiratory tract haemorrhage | 21.69 | 13.67 | 11 | 16374 | 1140 | 31679819 |
Cockroach allergy | 21.56 | 13.67 | 5 | 16380 | 43 | 31680916 |
Spontaneous haemorrhage | 21.10 | 13.67 | 7 | 16378 | 242 | 31680717 |
Adrenal cortex necrosis | 20.73 | 13.67 | 4 | 16381 | 12 | 31680947 |
Breath sounds abnormal | 20.64 | 13.67 | 20 | 16365 | 5892 | 31675067 |
Cardiac failure chronic | 20.56 | 13.67 | 22 | 16363 | 7281 | 31673678 |
Bronchial disorder | 20.04 | 13.67 | 11 | 16374 | 1338 | 31679621 |
Orthostatic intolerance | 19.72 | 13.67 | 9 | 16376 | 739 | 31680220 |
Necrotising ulcerative gingivostomatitis | 19.34 | 13.67 | 5 | 16380 | 70 | 31680889 |
Product taste abnormal | 19.23 | 13.67 | 10 | 16375 | 1091 | 31679868 |
Diarrhoea | 18.95 | 13.67 | 106 | 16279 | 352303 | 31328656 |
Nasal turbinate hypertrophy | 18.72 | 13.67 | 5 | 16380 | 80 | 31680879 |
Dysphonia | 18.53 | 13.67 | 36 | 16349 | 20555 | 31660404 |
Therapeutic product effect incomplete | 18.39 | 13.67 | 57 | 16328 | 43639 | 31637320 |
Circumstance or information capable of leading to medication error | 18.28 | 13.67 | 11 | 16374 | 1592 | 31679367 |
Increased upper airway secretion | 18.00 | 13.67 | 11 | 16374 | 1637 | 31679322 |
Oedema peripheral | 17.66 | 13.67 | 107 | 16278 | 109732 | 31571227 |
Laryngeal cryptococcosis | 17.63 | 13.67 | 3 | 16382 | 3 | 31680956 |
Death | 17.51 | 13.67 | 112 | 16273 | 360457 | 31320502 |
Pulmonary congestion | 17.31 | 13.67 | 27 | 16358 | 12956 | 31668003 |
Complicated appendicitis | 16.70 | 13.67 | 4 | 16381 | 40 | 31680919 |
Nocturnal dyspnoea | 16.34 | 13.67 | 7 | 16378 | 494 | 31680465 |
Aphonia | 16.10 | 13.67 | 13 | 16372 | 3012 | 31677947 |
Rebound effect | 15.98 | 13.67 | 12 | 16373 | 2501 | 31678458 |
Aortic dissection | 15.94 | 13.67 | 12 | 16373 | 2510 | 31678449 |
Paradoxical drug reaction | 15.72 | 13.67 | 13 | 16372 | 3116 | 31677843 |
Coronary artery stenosis | 15.55 | 13.67 | 21 | 16364 | 8849 | 31672110 |
Product use in unapproved indication | 15.54 | 13.67 | 17 | 16368 | 99154 | 31581805 |
Infective exacerbation of chronic obstructive airways disease | 15.16 | 13.67 | 10 | 16375 | 1698 | 31679261 |
Febrile neutropenia | 14.93 | 13.67 | 25 | 16360 | 121824 | 31559135 |
Disease progression | 14.74 | 13.67 | 15 | 16370 | 90449 | 31590510 |
Productive cough | 14.34 | 13.67 | 44 | 16341 | 33496 | 31647463 |
Arthritis allergic | 14.34 | 13.67 | 3 | 16382 | 15 | 31680944 |
Paranasal sinus mucosal hypertrophy | 14.18 | 13.67 | 4 | 16381 | 79 | 31680880 |
Therapeutic drug monitoring analysis incorrectly performed | 13.95 | 13.67 | 4 | 16381 | 84 | 31680875 |
Plasma cell myeloma | 13.74 | 13.67 | 6 | 16379 | 56525 | 31624434 |
Sleep apnoea syndrome | 13.74 | 13.67 | 30 | 16355 | 18595 | 31662364 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 947.08 | 12.21 | 643 | 34579 | 120150 | 70773072 |
Dyspnoea | 489.27 | 12.21 | 1134 | 34088 | 768926 | 70124296 |
Chronic obstructive pulmonary disease | 367.45 | 12.21 | 306 | 34916 | 77335 | 70815887 |
Wheezing | 324.11 | 12.21 | 310 | 34912 | 93860 | 70799362 |
Cough | 255.95 | 12.21 | 524 | 34698 | 324853 | 70568369 |
Product quality issue | 251.42 | 12.21 | 168 | 35054 | 30393 | 70862829 |
Obstructive airways disorder | 206.29 | 12.21 | 140 | 35082 | 25973 | 70867249 |
Emphysema | 174.75 | 12.21 | 103 | 35119 | 14957 | 70878265 |
Eosinophilic granulomatosis with polyangiitis | 166.56 | 12.21 | 62 | 35160 | 3151 | 70890071 |
Chest discomfort | 159 | 12.21 | 248 | 34974 | 124133 | 70769089 |
Polycystic ovaries | 154.69 | 12.21 | 57 | 35165 | 2815 | 70890407 |
Nasal polyps | 146.10 | 12.21 | 62 | 35160 | 4454 | 70888768 |
Sleep apnoea syndrome | 144.44 | 12.21 | 124 | 35098 | 32589 | 70860633 |
Sputum increased | 118.91 | 12.21 | 52 | 35170 | 4020 | 70889202 |
Gastrooesophageal reflux disease | 113.08 | 12.21 | 179 | 35043 | 90660 | 70802562 |
Productive cough | 99.76 | 12.21 | 156 | 35066 | 78181 | 70815041 |
Sputum discoloured | 98.93 | 12.21 | 79 | 35143 | 18772 | 70874450 |
Salpingo-oophorectomy unilateral | 93.06 | 12.21 | 27 | 35195 | 618 | 70892604 |
Pulmonary function test decreased | 90.86 | 12.21 | 51 | 35171 | 6750 | 70886472 |
Toxicity to various agents | 87.82 | 12.21 | 40 | 35182 | 382132 | 70511090 |
Nasal obstruction | 87.13 | 12.21 | 32 | 35190 | 1565 | 70891657 |
Rhinitis allergic | 81.01 | 12.21 | 53 | 35169 | 9242 | 70883980 |
Sensitisation | 80.16 | 12.21 | 34 | 35188 | 2439 | 70890783 |
Sinusitis fungal | 78.84 | 12.21 | 32 | 35190 | 2053 | 70891169 |
Bronchospasm | 78.21 | 12.21 | 75 | 35147 | 22717 | 70870505 |
Respiratory symptom | 78.19 | 12.21 | 38 | 35184 | 3743 | 70889479 |
Bronchiectasis | 77.17 | 12.21 | 64 | 35158 | 16033 | 70877189 |
Hyper IgE syndrome | 77.04 | 12.21 | 22 | 35200 | 475 | 70892747 |
Ejection fraction | 76.93 | 12.21 | 30 | 35192 | 1732 | 70891490 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 73.17 | 12.21 | 28 | 35194 | 1536 | 70891686 |
Skin candida | 73.05 | 12.21 | 29 | 35193 | 1756 | 70891466 |
Female genital tract fistula | 72.75 | 12.21 | 34 | 35188 | 3069 | 70890153 |
Embolism venous | 68.73 | 12.21 | 35 | 35187 | 3810 | 70889412 |
Asthmatic crisis | 68.11 | 12.21 | 28 | 35194 | 1856 | 70891366 |
Blood test abnormal | 67.86 | 12.21 | 57 | 35165 | 14533 | 70878689 |
Sinus pain | 66.96 | 12.21 | 32 | 35190 | 3037 | 70890185 |
Eczema | 64.96 | 12.21 | 82 | 35140 | 33699 | 70859523 |
Rheumatoid arthritis | 63.26 | 12.21 | 33 | 35189 | 291772 | 70601450 |
Off label use | 63.23 | 12.21 | 176 | 35046 | 742884 | 70150338 |
Completed suicide | 60.08 | 12.21 | 19 | 35203 | 227116 | 70666106 |
Candida infection | 58.99 | 12.21 | 79 | 35143 | 34394 | 70858828 |
Eosinophil count | 57.29 | 12.21 | 13 | 35209 | 105 | 70893117 |
Hepatic vein dilatation | 57.16 | 12.21 | 15 | 35207 | 233 | 70892989 |
Dyspnoea exertional | 56.35 | 12.21 | 122 | 35100 | 78308 | 70814914 |
Restrictive pulmonary disease | 56.34 | 12.21 | 26 | 35196 | 2280 | 70890942 |
Oedema peripheral | 54.47 | 12.21 | 241 | 34981 | 227850 | 70665372 |
Full blood count abnormal | 53.98 | 12.21 | 75 | 35147 | 33803 | 70859419 |
Chronic sinusitis | 52.16 | 12.21 | 39 | 35183 | 8412 | 70884810 |
Liver palpable | 52.05 | 12.21 | 15 | 35207 | 335 | 70892887 |
Joint swelling | 51.46 | 12.21 | 31 | 35191 | 253180 | 70640042 |
Dysphonia | 49.38 | 12.21 | 89 | 35133 | 50011 | 70843211 |
Sleep disorder due to a general medical condition | 48.86 | 12.21 | 41 | 35181 | 10435 | 70882787 |
Pneumonia | 47.99 | 12.21 | 479 | 34743 | 595753 | 70297469 |
Intentional product use issue | 47.74 | 12.21 | 3 | 35219 | 120139 | 70773083 |
Diastolic dysfunction | 46.25 | 12.21 | 38 | 35184 | 9395 | 70883827 |
Hypothyroidism | 46.01 | 12.21 | 82 | 35140 | 45673 | 70847549 |
Throat irritation | 44.49 | 12.21 | 70 | 35152 | 35234 | 70857988 |
Respiratory disorder | 44.44 | 12.21 | 74 | 35148 | 39049 | 70854173 |
Breath sounds abnormal | 44.37 | 12.21 | 43 | 35179 | 13188 | 70880034 |
Neurosensory hypoacusis | 44.29 | 12.21 | 12 | 35210 | 212 | 70893010 |
Drug abuse | 43.29 | 12.21 | 10 | 35212 | 147246 | 70745976 |
Ventricular enlargement | 42.01 | 12.21 | 14 | 35208 | 512 | 70892710 |
Hysterectomy | 41.73 | 12.21 | 29 | 35193 | 5583 | 70887639 |
Febrile neutropenia | 41.52 | 12.21 | 25 | 35197 | 204293 | 70688929 |
Arthropathy | 40.66 | 12.21 | 12 | 35210 | 150045 | 70743177 |
Pulmonary mass | 40.53 | 12.21 | 57 | 35165 | 25976 | 70867246 |
Inferior vena cava dilatation | 40.05 | 12.21 | 15 | 35207 | 775 | 70892447 |
Nephrectomy | 39.95 | 12.21 | 19 | 35203 | 1784 | 70891438 |
Vocal cord dysfunction | 39.72 | 12.21 | 13 | 35209 | 449 | 70892773 |
Diverticulum | 39.48 | 12.21 | 41 | 35181 | 13652 | 70879570 |
Mycobacterium avium complex infection | 38.62 | 12.21 | 25 | 35197 | 4281 | 70888941 |
Atrial enlargement | 38.35 | 12.21 | 14 | 35208 | 673 | 70892549 |
Contraindicated product administered | 37.89 | 12.21 | 10 | 35212 | 134602 | 70758620 |
Feeling jittery | 37.75 | 12.21 | 37 | 35185 | 11506 | 70881716 |
Tricuspid valve incompetence | 37.06 | 12.21 | 45 | 35177 | 17772 | 70875450 |
Hiatus hernia | 37.02 | 12.21 | 49 | 35173 | 21085 | 70872137 |
Bronchial obstruction | 36.61 | 12.21 | 20 | 35202 | 2510 | 70890712 |
Treatment failure | 36.45 | 12.21 | 13 | 35209 | 144129 | 70749093 |
Pain | 35.62 | 12.21 | 176 | 35046 | 628640 | 70264582 |
Product use issue | 35.20 | 12.21 | 23 | 35199 | 179914 | 70713308 |
Forced expiratory volume decreased | 34.89 | 12.21 | 29 | 35193 | 7285 | 70885937 |
Facial nerve disorder | 34.25 | 12.21 | 13 | 35209 | 697 | 70892525 |
Osteoporosis | 33.89 | 12.21 | 75 | 35147 | 48832 | 70844390 |
Rales | 33.58 | 12.21 | 42 | 35180 | 17093 | 70876129 |
Musculoskeletal stiffness | 33.05 | 12.21 | 16 | 35206 | 147744 | 70745478 |
Suffocation feeling | 32.80 | 12.21 | 16 | 35206 | 1588 | 70891634 |
Product container issue | 32.69 | 12.21 | 14 | 35208 | 1028 | 70892194 |
CFTR gene mutation | 32.55 | 12.21 | 8 | 35214 | 94 | 70893128 |
Bronchopulmonary aspergillosis allergic | 32.53 | 12.21 | 17 | 35205 | 1952 | 70891270 |
Dyspnoea at rest | 32.45 | 12.21 | 27 | 35195 | 6792 | 70886430 |
Alopecia | 31.77 | 12.21 | 31 | 35191 | 198459 | 70694763 |
Lung consolidation | 31.69 | 12.21 | 29 | 35193 | 8277 | 70884945 |
Chest pain | 31.40 | 12.21 | 223 | 34999 | 251037 | 70642185 |
Breast neoplasm | 31.24 | 12.21 | 13 | 35209 | 889 | 70892333 |
Pericarditis | 31.16 | 12.21 | 3 | 35219 | 84702 | 70808520 |
Platelet count decreased | 30.71 | 12.21 | 26 | 35196 | 178196 | 70715026 |
Pulmonary congestion | 30.48 | 12.21 | 49 | 35173 | 25105 | 70868117 |
White blood cell count decreased | 30.34 | 12.21 | 24 | 35198 | 170117 | 70723105 |
Increased bronchial secretion | 30.33 | 12.21 | 19 | 35203 | 3074 | 70890148 |
Hangover | 29.98 | 12.21 | 16 | 35206 | 1917 | 70891305 |
Systemic lupus erythematosus | 29.78 | 12.21 | 7 | 35215 | 101895 | 70791327 |
Swollen tongue | 29.35 | 12.21 | 60 | 35162 | 36986 | 70856236 |
Drug intolerance | 28.92 | 12.21 | 42 | 35180 | 225645 | 70667577 |
Lipohypertrophy | 28.61 | 12.21 | 12 | 35210 | 837 | 70892385 |
Infusion related reaction | 28.13 | 12.21 | 34 | 35188 | 197500 | 70695722 |
Disease progression | 28.06 | 12.21 | 22 | 35200 | 156650 | 70736572 |
Urinary tract discomfort | 28 | 12.21 | 10 | 35212 | 451 | 70892771 |
Peripheral vascular disorder | 27.87 | 12.21 | 26 | 35196 | 7606 | 70885616 |
Bronchitis chronic | 27.72 | 12.21 | 20 | 35202 | 4084 | 70889138 |
Neutropenia | 27.30 | 12.21 | 54 | 35168 | 257102 | 70636120 |
Increased upper airway secretion | 27.02 | 12.21 | 19 | 35203 | 3726 | 70889496 |
Eosinophilia | 27.00 | 12.21 | 61 | 35161 | 40258 | 70852964 |
Nasal congestion | 26.25 | 12.21 | 82 | 35140 | 65590 | 70827632 |
Stridor | 26.05 | 12.21 | 21 | 35201 | 5055 | 70888167 |
Transient ischaemic attack | 25.89 | 12.21 | 65 | 35157 | 45879 | 70847343 |
Diarrhoea | 25.72 | 12.21 | 257 | 34965 | 783084 | 70110138 |
Alveolar osteitis | 25.71 | 12.21 | 10 | 35212 | 573 | 70892649 |
Peripheral swelling | 25.70 | 12.21 | 49 | 35173 | 236514 | 70656708 |
Limb injury | 25.69 | 12.21 | 46 | 35176 | 25706 | 70867516 |
Angioplasty | 25.41 | 12.21 | 14 | 35208 | 1786 | 70891436 |
Rhinitis | 25.39 | 12.21 | 30 | 35192 | 11517 | 70881705 |
Palpitations | 24.88 | 12.21 | 115 | 35107 | 110638 | 70782584 |
Hepatic enzyme increased | 24.57 | 12.21 | 25 | 35197 | 156965 | 70736257 |
Peak expiratory flow rate decreased | 24.47 | 12.21 | 10 | 35212 | 653 | 70892569 |
Bronchial disorder | 24.45 | 12.21 | 15 | 35207 | 2339 | 70890883 |
Pulmonary embolism | 24.12 | 12.21 | 146 | 35076 | 155721 | 70737501 |
Heart rate increased | 23.68 | 12.21 | 110 | 35112 | 106038 | 70787184 |
Foreign body aspiration | 23.63 | 12.21 | 8 | 35214 | 307 | 70892915 |
Plasma cell myeloma | 23.54 | 12.21 | 4 | 35218 | 73197 | 70820025 |
Carpal tunnel syndrome | 23.14 | 12.21 | 35 | 35187 | 17022 | 70876200 |
Pharyngeal oedema | 22.43 | 12.21 | 33 | 35189 | 15663 | 70877559 |
Cockroach allergy | 22.41 | 12.21 | 6 | 35216 | 101 | 70893121 |
Oropharyngeal pain | 22.37 | 12.21 | 101 | 35121 | 96209 | 70797013 |
Fungal oesophagitis | 22.13 | 12.21 | 10 | 35212 | 835 | 70892387 |
Psoriatic arthropathy | 22.06 | 12.21 | 3 | 35219 | 64768 | 70828454 |
Burning sensation | 22.05 | 12.21 | 67 | 35155 | 52803 | 70840419 |
Toxic neuropathy | 21.76 | 12.21 | 10 | 35212 | 868 | 70892354 |
Oedema mouth | 21.51 | 12.21 | 15 | 35207 | 2903 | 70890319 |
Skin lesion | 21.24 | 12.21 | 54 | 35168 | 38406 | 70854816 |
Therapeutic product effect decreased | 21.01 | 12.21 | 24 | 35198 | 142994 | 70750228 |
Respiratory tract haemorrhage | 20.75 | 12.21 | 12 | 35210 | 1680 | 70891542 |
Dyslipidaemia | 20.66 | 12.21 | 25 | 35197 | 9835 | 70883387 |
Bronchial hyperreactivity | 20.54 | 12.21 | 14 | 35208 | 2612 | 70890610 |
Throat tightness | 20.38 | 12.21 | 41 | 35181 | 24981 | 70868241 |
Iron deficiency anaemia | 20.24 | 12.21 | 39 | 35183 | 23033 | 70870189 |
Nervous system disorder | 20.19 | 12.21 | 40 | 35182 | 24106 | 70869116 |
Adrenal cortex necrosis | 20.00 | 12.21 | 4 | 35218 | 16 | 70893206 |
Blood electrolytes abnormal | 19.98 | 12.21 | 12 | 35210 | 1802 | 70891420 |
Bordetella test positive | 19.83 | 12.21 | 3 | 35219 | 0 | 70893222 |
Crepitations | 19.76 | 12.21 | 23 | 35199 | 8691 | 70884531 |
Allergic sinusitis | 19.71 | 12.21 | 8 | 35214 | 513 | 70892709 |
Ear congestion | 19.62 | 12.21 | 13 | 35209 | 2314 | 70890908 |
Syncope | 19.49 | 12.21 | 145 | 35077 | 165564 | 70727658 |
Infection | 19.30 | 12.21 | 48 | 35174 | 210737 | 70682485 |
Middle insomnia | 19.30 | 12.21 | 29 | 35193 | 14024 | 70879198 |
Rebound effect | 19.26 | 12.21 | 19 | 35203 | 5952 | 70887270 |
Sepsis | 19.19 | 12.21 | 60 | 35162 | 244485 | 70648737 |
Arthralgia | 19.15 | 12.21 | 159 | 35063 | 503231 | 70389991 |
Cardiac disorder | 19.15 | 12.21 | 69 | 35153 | 59346 | 70833876 |
Animal scratch | 19.04 | 12.21 | 10 | 35212 | 1160 | 70892062 |
Psoriasis | 18.68 | 12.21 | 13 | 35209 | 98420 | 70794802 |
Tunnel vision | 18.56 | 12.21 | 10 | 35212 | 1221 | 70892001 |
Product dose omission issue | 18.52 | 12.21 | 177 | 35045 | 217291 | 70675931 |
Product use in unapproved indication | 18.41 | 12.21 | 48 | 35174 | 207430 | 70685792 |
Sinusitis | 18.20 | 12.21 | 145 | 35077 | 169050 | 70724172 |
Product taste abnormal | 18.17 | 12.21 | 12 | 35210 | 2124 | 70891098 |
Weaning failure | 17.83 | 12.21 | 8 | 35214 | 657 | 70892565 |
Urinary retention | 17.79 | 12.21 | 62 | 35160 | 52458 | 70840764 |
Macrocytosis | 17.76 | 12.21 | 13 | 35209 | 2714 | 70890508 |
Laryngeal cryptococcosis | 17.75 | 12.21 | 3 | 35219 | 3 | 70893219 |
Orthostatic intolerance | 17.69 | 12.21 | 11 | 35211 | 1756 | 70891466 |
Lower respiratory tract infection | 17.41 | 12.21 | 105 | 35117 | 111808 | 70781414 |
Lung neoplasm malignant | 17.20 | 12.21 | 38 | 35184 | 24704 | 70868518 |
Therapeutic product effect incomplete | 17.11 | 12.21 | 110 | 35112 | 119772 | 70773450 |
Carnitine deficiency | 16.99 | 12.21 | 6 | 35216 | 262 | 70892960 |
Respiratory tract congestion | 16.93 | 12.21 | 31 | 35191 | 17622 | 70875600 |
Drug hypersensitivity | 16.87 | 12.21 | 70 | 35152 | 262389 | 70630833 |
Essential hypertension | 16.86 | 12.21 | 17 | 35205 | 5467 | 70887755 |
Kyphosis | 16.84 | 12.21 | 12 | 35210 | 2404 | 70890818 |
Pyrexia | 16.76 | 12.21 | 207 | 35015 | 606745 | 70286477 |
Circumstance or information capable of leading to medication error | 16.64 | 12.21 | 14 | 35208 | 3576 | 70889646 |
Anosmia | 16.62 | 12.21 | 16 | 35206 | 4867 | 70888355 |
Lip pruritus | 16.61 | 12.21 | 8 | 35214 | 772 | 70892450 |
Encephalopathy | 16.57 | 12.21 | 5 | 35217 | 61656 | 70831566 |
Panic reaction | 16.47 | 12.21 | 15 | 35207 | 4256 | 70888966 |
Bladder pain | 16.43 | 12.21 | 11 | 35211 | 1993 | 70891229 |
Infective exacerbation of chronic obstructive airways disease | 16.42 | 12.21 | 12 | 35210 | 2499 | 70890723 |
Spontaneous haemorrhage | 16.37 | 12.21 | 7 | 35215 | 512 | 70892710 |
Intentional overdose | 16.18 | 12.21 | 15 | 35207 | 98420 | 70794802 |
Respiratory tract infection | 16.08 | 12.21 | 52 | 35170 | 42346 | 70850876 |
Restless legs syndrome | 15.98 | 12.21 | 31 | 35191 | 18397 | 70874825 |
Product prescribing error | 15.90 | 12.21 | 49 | 35173 | 38903 | 70854319 |
Presbyacusis | 15.89 | 12.21 | 12 | 35210 | 2625 | 70890597 |
Tubulointerstitial nephritis and uveitis syndrome | 15.86 | 12.21 | 6 | 35216 | 319 | 70892903 |
Heart rate irregular | 15.64 | 12.21 | 41 | 35181 | 29702 | 70863520 |
Hypomagnesaemia | 15.47 | 12.21 | 50 | 35172 | 40714 | 70852508 |
Choking | 15.44 | 12.21 | 23 | 35199 | 11037 | 70882185 |
Pancreatitis relapsing | 15.34 | 12.21 | 8 | 35214 | 915 | 70892307 |
Anxiety | 15.28 | 12.21 | 172 | 35050 | 220158 | 70673064 |
Cardiac failure chronic | 15.27 | 12.21 | 22 | 35200 | 10247 | 70882975 |
COVID-19 | 15.26 | 12.21 | 18 | 35204 | 105739 | 70787483 |
Impaired healing | 15.24 | 12.21 | 9 | 35213 | 74365 | 70818857 |
Ejection fraction abnormal | 15.23 | 12.21 | 10 | 35212 | 1753 | 70891469 |
Bronchitis | 15.17 | 12.21 | 105 | 35117 | 117138 | 70776084 |
Haemoptysis | 15.11 | 12.21 | 58 | 35164 | 51394 | 70841828 |
Coma | 15.09 | 12.21 | 14 | 35208 | 91830 | 70801392 |
Lip swelling | 15.00 | 12.21 | 44 | 35178 | 34010 | 70859212 |
Nasal inflammation | 14.91 | 12.21 | 7 | 35215 | 638 | 70892584 |
Anaphylactic reaction | 14.78 | 12.21 | 75 | 35147 | 74899 | 70818323 |
Renal disorder | 14.77 | 12.21 | 47 | 35175 | 37962 | 70855260 |
Hypertension | 14.58 | 12.21 | 217 | 35005 | 295816 | 70597406 |
Status asthmaticus | 14.58 | 12.21 | 8 | 35214 | 1013 | 70892209 |
Coronary artery stenosis | 14.54 | 12.21 | 23 | 35199 | 11621 | 70881601 |
Restlessness | 14.50 | 12.21 | 50 | 35172 | 42078 | 70851144 |
Fungal infection | 14.26 | 12.21 | 46 | 35176 | 37421 | 70855801 |
Arthritis allergic | 14.14 | 12.21 | 3 | 35219 | 17 | 70893205 |
Discomfort | 14.11 | 12.21 | 19 | 35203 | 105417 | 70787805 |
Type 2 diabetes mellitus | 14.04 | 12.21 | 51 | 35171 | 44029 | 70849193 |
Cushingoid | 14.00 | 12.21 | 19 | 35203 | 8369 | 70884853 |
Paranasal sinus mucosal hypertrophy | 13.98 | 12.21 | 4 | 35218 | 87 | 70893135 |
Fatigue | 13.88 | 12.21 | 308 | 34914 | 824011 | 70069211 |
Neutropenic sepsis | 13.85 | 12.21 | 35 | 35187 | 24795 | 70868427 |
Aortic dissection | 13.84 | 12.21 | 13 | 35209 | 3834 | 70889388 |
Stomatitis | 13.61 | 12.21 | 27 | 35195 | 128484 | 70764738 |
Swelling | 13.59 | 12.21 | 48 | 35174 | 188491 | 70704731 |
Dust allergy | 13.47 | 12.21 | 8 | 35214 | 1176 | 70892046 |
Mobility decreased | 13.35 | 12.21 | 19 | 35203 | 102980 | 70790242 |
Panic attack | 13.21 | 12.21 | 32 | 35190 | 22087 | 70871135 |
Depression | 13.19 | 12.21 | 154 | 35068 | 198820 | 70694402 |
Gastrointestinal disorder | 13.12 | 12.21 | 20 | 35202 | 105407 | 70787815 |
Bone marrow failure | 13.12 | 12.21 | 4 | 35218 | 49006 | 70844216 |
Death | 12.94 | 12.21 | 177 | 35045 | 509884 | 70383338 |
Mouth ulceration | 12.91 | 12.21 | 42 | 35180 | 34307 | 70858915 |
Thrombocytopenia | 12.87 | 12.21 | 68 | 35154 | 239042 | 70654180 |
Tracheo-oesophageal fistula | 12.75 | 12.21 | 6 | 35216 | 550 | 70892672 |
Oral candidiasis | 12.72 | 12.21 | 34 | 35188 | 24918 | 70868304 |
Red blood cell count decreased | 12.68 | 12.21 | 5 | 35217 | 52156 | 70841066 |
Face and mouth X-ray abnormal | 12.65 | 12.21 | 3 | 35219 | 30 | 70893192 |
Coronary artery disease | 12.53 | 12.21 | 63 | 35159 | 62673 | 70830549 |
Complicated appendicitis | 12.37 | 12.21 | 4 | 35218 | 133 | 70893089 |
Nocturnal dyspnoea | 12.29 | 12.21 | 8 | 35214 | 1383 | 70891839 |
Hypotension | 12.27 | 12.21 | 135 | 35087 | 404246 | 70488976 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Congenital naevus | 27.87 | 15.89 | 5 | 6 | 70 | 89711 |
Source | Code | Description |
---|---|---|
ATC | R03AC13 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists |
ATC | R03AK07 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AK08 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AK09 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AK11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AL05 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
ATC | R03AL07 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
ATC | R03AL09 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
ATC | R03AL10 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
ATC | R03AL11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
ATC | R03CC15 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists |
FDA MoA | N0000009922 | Adrenergic beta2-Agonists |
CHEBI has role | CHEBI:35522 | beta-adrenergic agonists |
CHEBI has role | CHEBI:35523 | bronchodilator |
CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D000322 | Adrenergic Agonists |
MeSH PA | D058666 | Adrenergic beta-2 Receptor Agonists |
MeSH PA | D000318 | Adrenergic beta-Agonists |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D019141 | Respiratory System Agents |
FDA EPC | N0000175779 | beta2-Adrenergic Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pulmonary emphysema | indication | 87433001 | |
Non-allergic asthma | indication | 266361008 | DOID:9360 |
Severe chronic obstructive pulmonary disease | indication | 313299006 | |
Allergic asthma | indication | 389145006 | DOID:9415 |
Adjunct Therapy to Achieve Long-term Asthma Control | indication | ||
Exercise-Induced Bronchospasm Prevention | indication | ||
COPD Associated with Chronic Bronchitis | indication | ||
Bronchospasm Prevention with COPD | indication | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Asthenia | contraindication | 13791008 | |
Measles | contraindication | 14189004 | DOID:8622 |
Disease caused by parasite | contraindication | 17322007 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Acute tuberculosis | contraindication | 25629007 | |
Immunosuppression | contraindication | 38013005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Varicella | contraindication | 38907003 | DOID:8659 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Bilateral cataracts | contraindication | 95722004 | |
Prolonged QT interval | contraindication | 111975006 | |
Seizure disorder | contraindication | 128613002 | |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Exacerbation of asthma | contraindication | 281239006 | |
Osteopenia | contraindication | 312894000 | |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Congenital long QT syndrome | contraindication | 442917000 | |
Uncontrolled Bacterial Infections | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.23 | acidic |
pKa2 | 12.47 | acidic |
pKa3 | 8.49 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.4MG/INH;0.012MG/INH | DUAKLIR PRESSAIR | COVIS | N210595 | March 29, 2019 | RX | POWDER, METERED | INHALATION | RE46417 | Feb. 10, 2025 | MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.4MG/INH;0.012MG/INH | DUAKLIR PRESSAIR | COVIS | N210595 | March 29, 2019 | RX | POWDER, METERED | INHALATION | 10085974 | March 13, 2029 | MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.4MG/INH;0.012MG/INH | DUAKLIR PRESSAIR | COVIS | N210595 | March 29, 2019 | RX | POWDER, METERED | INHALATION | 11000517 | March 13, 2029 | MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.0048MG/INH;0.0090MG/INH | BEVESPI AEROSPHERE | ASTRAZENECA | N208294 | April 25, 2016 | RX | AEROSOL, METERED | INHALATION | 10716753 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.0048MG/INH;0.0090MG/INH | BEVESPI AEROSPHERE | ASTRAZENECA | N208294 | April 25, 2016 | RX | AEROSOL, METERED | INHALATION | 8324266 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.0048MG/INH;0.0090MG/INH | BEVESPI AEROSPHERE | ASTRAZENECA | N208294 | April 25, 2016 | RX | AEROSOL, METERED | INHALATION | 8703806 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.0048MG/INH;0.0090MG/INH | BEVESPI AEROSPHERE | ASTRAZENECA | N208294 | April 25, 2016 | RX | AEROSOL, METERED | INHALATION | 8808713 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.0048MG/INH;0.0090MG/INH | BEVESPI AEROSPHERE | ASTRAZENECA | N208294 | April 25, 2016 | RX | AEROSOL, METERED | INHALATION | 9415009 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.0048MG/INH;0.0090MG/INH | BEVESPI AEROSPHERE | ASTRAZENECA | N208294 | April 25, 2016 | RX | AEROSOL, METERED | INHALATION | 9463161 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 10716753 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 8324266 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 8703806 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 8808713 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 9415009 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 9463161 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.0048MG/INH;0.0090MG/INH | BEVESPI AEROSPHERE | ASTRAZENECA | N208294 | April 25, 2016 | RX | AEROSOL, METERED | INHALATION | 8815258 | March 17, 2031 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 8815258 | March 17, 2031 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
0.4MG/INH;0.012MG/INH | DUAKLIR PRESSAIR | COVIS | N210595 | March 29, 2019 | RX | POWDER, METERED | INHALATION | March 29, 2022 | NEW COMBINATION |
0.005MG/INH;0.05MG/INH | DULERA | ORGANON LLC | N022518 | Aug. 12, 2019 | RX | AEROSOL, METERED | INHALATION | Aug. 12, 2022 | NEW STRENGTH |
0.005MG/INH;0.05MG/INH | DULERA | ORGANON LLC | N022518 | Aug. 12, 2019 | RX | AEROSOL, METERED | INHALATION | Feb. 12, 2023 | PEDIATRIC EXCLUSIVITY |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | July 23, 2023 | NEW COMBINATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-2 adrenergic receptor | GPCR | AGONIST | Kd | 8.60 | CHEMBL | CHEMBL | |||
D(2) dopamine receptor | GPCR | Ki | 4.89 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 6.50 | CHEMBL | |||||
Beta-3 adrenergic receptor | GPCR | EC50 | 7.60 | CHEMBL | |||||
Heat shock protein HSP 90-alpha | Cytosolic other | IC50 | 8.52 | WOMBAT-PK | |||||
D(3) dopamine receptor | GPCR | Ki | 5.79 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | EC50 | 8.80 | CHEMBL |
ID | Source |
---|---|
4021266 | VUID |
N0000148706 | NUI |
D01373 | KEGG_DRUG |
183814-30-4 | SECONDARY_CAS_RN |
4021266 | VANDF |
4021267 | VANDF |
4026240 | VANDF |
C0060657 | UMLSCUI |
CHEBI:5147 | CHEBI |
CHEMBL1256786 | ChEMBL_ID |
CHEMBL3989798 | ChEMBL_ID |
DB00983 | DRUGBANK_ID |
D000068759 | MESH_DESCRIPTOR_UI |
3083544 | PUBCHEM_CID |
3465 | IUPHAR_LIGAND_ID |
4935 | INN_ID |
5ZZ84GCW8B | UNII |
236216 | RXNORM |
15056 | MMSL |
347879 | MMSL |
d04572 | MMSL |
005421 | NDDF |
005422 | NDDF |
016698 | NDDF |
129490002 | SNOMEDCT_US |
386171009 | SNOMEDCT_US |
414289007 | SNOMEDCT_US |
447213002 | SNOMEDCT_US |
CHEMBL2133469 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Dulera | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0085-4610 | AEROSOL | 5 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
Dulera | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0085-7206 | AEROSOL | 5 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
Formoterol fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4061 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
Formoterol fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4061 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
SYMBICORT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0186-0370 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
SYMBICORT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0186-0370 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
SYMBICORT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0186-0372 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
SYMBICORT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0186-0372 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
DUAKLIR PRESSAIR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0310-0900 | POWDER, METERED | 12 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
BEVESPI AEROSPHERE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0310-4600 | AEROSOL, METERED | 4.80 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
BEVESPI AEROSPHERE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0310-4600 | AEROSOL, METERED | 4.80 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
BREZTRI | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0310-4616 | AEROSOL, METERED | 4.80 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
Budesonide and Formoterol Fumarate Dihydrate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0310-7370 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Budesonide and Formoterol Fumarate Dihydrate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0310-7372 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
FORMOTEROL FUMARATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1631 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
BREYNA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-7502 | AEROSOL, METERED | 4.50 ug | RESPIRATORY (INHALATION) | ANDA | 29 sections |
BREYNA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-7503 | AEROSOL, METERED | 4.50 ug | RESPIRATORY (INHALATION) | ANDA | 29 sections |
Perforomist | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49502-605 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
Dulera | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-1916 | AEROSOL | 5 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
Budesonide and Formoterol Fumarate Dihydrate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 53002-2666 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 29 sections |
Budesonide and Formoterol Fumarate Dihydrate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 53002-2667 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 29 sections |
Formoterol Fumarate | Human Prescription Drug Label | 1 | 62332-655 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Formoterol Fumarate | Human Prescription Drug Label | 1 | 62332-655 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Formoterol fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8813 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
Formoterol fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8813 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
Formoterol fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8814 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
Formoterol fumarate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8814 | SOLUTION | 20 ug | RESPIRATORY (INHALATION) | ANDA | 28 sections |
SYMBICORT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70518-2696 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
Budesonide and Formoterol Fumarate Dihydrate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70518-3107 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Budesonide and Formoterol Fumarate Dihydrate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70518-3107 | AEROSOL | 4.50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |