fenoterol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 1155 13392-18-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fenoterol
  • phenoterol
  • fenoterol hydrobromide
  • fenoterol hydrochloride
  • fenoterol HCl
A synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
  • Molecular weight: 303.36
  • Formula: C17H21NO4
  • CLOGP: 0.98
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 5
  • TPSA: 92.95
  • ALOGS: -3.27
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.60 mg Inhal.aerosol
0.60 mg Inhal.powder
4 mg Inhal.solution
10 mg O
10 mg R

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.08 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 2 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 29 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.53 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.87 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1965 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC G02CA03 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
OTHER GYNECOLOGICALS
Sympathomimetics, labour repressants
ATC R03AC04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03AL01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03CC04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
CHEBI has role CHEBI:35523 bronchodilator agent
CHEBI has role CHEBI:35524 sympathomimetic agent
CHEBI has role CHEBI:35522 beta-adrenergic agonist
CHEBI has role CHEBI:66993 tocolytic agent
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D015149 Tocolytic Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.48 acidic
pKa2 11.02 acidic
pKa3 11.67 acidic
pKa4 12.2 acidic
pKa5 8.03 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST EC50 6.90 WOMBAT-PK IUPHAR
Beta-2 adrenergic receptor GPCR IC50 7.22 CHEMBL

External reference:

IDSource
D005280 MESH_DESCRIPTOR_UI
4025246 VUID
N0000171778 NUI
C0015840 UMLSCUI
D01428 KEGG_DRUG
22M9P70OQ9 UNII
3073 INN_ID
130156-24-0 SECONDARY_CAS_RN
349924004 SNOMEDCT_US
4333 RXNORM
395976006 SNOMEDCT_US
4025246 VANDF
003460 NDDF
CHEBI:149226 CHEBI
CHEMBL32800 ChEMBL_ID
CHEMBL537445 ChEMBL_ID
DB01288 DRUGBANK_ID
3343 PUBCHEM_CID
557 IUPHAR_LIGAND_ID

Pharmaceutical products:

None