Scroll

isoprenaline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
bronchodilators, phenethylamine derivatives	1499	7683-59-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: isoprenaline isoproterenol isoproterenol hydrochloride DL-Isoproterenol isoprenalin isoprenaline sulfate DL-isoprenaline hydrochloride isoproterenol sulfate isoproterenol HCl DL-isoprenaline HCl	Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. Molecular weight: 211.26 Formula: C11H17NO3 CLOGP: 0.15 LIPINSKI: 0 HAC: 4 HDO: 4 TPSA: 72.72 ALOGS: -1.56 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

isoprenaline
isoproterenol
isoproterenol hydrochloride
DL-Isoproterenol
isoprenalin
isoprenaline sulfate
DL-isoprenaline hydrochloride
isoproterenol sulfate
isoproterenol HCl
DL-isoprenaline HCl

Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.

Molecular weight: 211.26
Formula: C11H17NO3
CLOGP: 0.15
LIPINSKI: 0
HAC: 4
HDO: 4
TPSA: 72.72
ALOGS: -1.56
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
90	mg	O
90	mg	P
0.64	mg	Inhal.aerosol
10	mg	Inhal.solution
40	mg	O

ADMET properties:

Show entries

Search:

Property	Value	Reference
CL (Clearance)	56 mL/min/kg	Lombardo F, Berellini G, Obach RS
S (Water solubility)	50 mg/mL	Bocci G, Oprea TI, Benet LZ
Vd (Volume of distribution)	1.50 L/kg	Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Hosey CM, Chan R, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.79 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma)	0.71 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.41 hours	Lombardo F, Berellini G, Obach RS
BA (Bioavailability)	0 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Showing 1 to 8 of 8 entries

Previous1Next

Approvals:

Date	Agency	Company	Orphan
March 9, 1956	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	188.91	72.69	44	337	21602	34934948

Showing 1 to 1 of 1 entries

Previous1Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	171.13	51.17	46	717	44535	79699090
Drug ineffective	95.20	51.17	79	684	1080834	78662791
Ventricular tachycardia	70.86	51.17	23	740	41912	79701713
Gallbladder rupture	52.85	51.17	9	754	973	79742652
Ventricular fibrillation	51.82	51.17	17	746	31909	79711716

Showing 1 to 5 of 5 entries

Previous1Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	C01CA02	CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents
ATC	R03AB02	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Non-selective beta-adrenoreceptor agonists
ATC	R03AK02	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC	R03CB01	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Non-selective beta-adrenoreceptor agonists
ATC	R03CB51	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Non-selective beta-adrenoreceptor agonists
CHEBI has role	CHEBI:35522	beta-adrenergic agonists
CHEBI has role	CHEBI:35523	bronchodilator
CHEBI has role	CHEBI:35524	sympathomimetic
CHEBI has role	CHEBI:38147	cardiotonic drugs
FDA EPC	N0000175555	beta-Adrenergic Agonist

Showing 1 to 10 of 23 entries

Previous1 2 3Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Hypovolemic shock	indication	39419009
Low cardiac output syndrome	indication	44088000
Common cold	indication	82272006	DOID:10459
Atrioventricular block	indication	233917008	DOID:0050820
Cardiac arrest	indication	410429000	DOID:0060319
Syncope due to Heart Block	indication
Thick Bronchial Secretions	indication
Tachyarrhythmia	contraindication	6285003
Myocardial infarction	contraindication	22298006	DOID:5844
Hyperthyroidism	contraindication	34486009	DOID:7998

Showing 1 to 10 of 18 entries

Previous1 2Next

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Show entries

Search:

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.97	acidic
pKa2	12.82	acidic
pKa3	13.92	acidic
pKa4	8.94	Basic

Showing 1 to 4 of 4 entries

Previous1Next

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN	AGONIST	EC50	9	WOMBAT-PK	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN	AGONIST	EC50	9.80	WOMBAT-PK	CHEMBL
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	4.92	CHEMBL
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	5.33	CHEMBL
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN	AGONIST	EC50	8.50	WOMBAT-PK
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	5.54	CHEMBL
Taste receptor type 2 member 14	GPCR	Q9NYV8	T2R14_HUMAN		EC50	8.31	CHEMBL
Taste receptor type 2 member 46	GPCR	P59540	T2R46_HUMAN		EC50	8.31	CHEMBL
Taste receptor type 2 member 38	GPCR	P59533	T2R38_HUMAN		EC50	8.31	CHEMBL
Taste receptor type 2 member 39	GPCR	P59534	T2R39_HUMAN		EC50	8.31	CHEMBL

Showing 1 to 10 of 40 entries

Previous1 2 3 4Next

External reference:

Show entries

Search:

ID	Source
5FW	PDB_CHEM_ID
001778	NDDF
001779	NDDF
001780	NDDF
29301006	SNOMEDCT_US
2959	MMSL
372781009	SNOMEDCT_US
3779	PUBCHEM_CID
4018235	VANDF
4018236	VANDF

Showing 1 to 10 of 33 entries

Previous1 2 3 4Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ISOPROTERENOL	HUMAN PRESCRIPTION DRUG LABEL	1	69097-521	INJECTION, SOLUTION	0.20 mg	INTRACARDIAC	ANDA	11 sections
ISOPROTERENOL	HUMAN PRESCRIPTION DRUG LABEL	1	69097-522	INJECTION, SOLUTION	1 mg	INTRACARDIAC	ANDA	11 sections
ISOPROTERENOL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0548-9501	INJECTION, SOLUTION	0.20 mg	INTRAVENOUS	ANDA	19 sections
ISOPROTERENOL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0548-9502	INJECTION, SOLUTION	0.20 mg	INTRAVENOUS	ANDA	19 sections
Isoproterenol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	14789-011	INJECTION, SOLUTION	0.20 mg	INTRAMUSCULAR	ANDA	27 sections
Isoproterenol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	14789-011	INJECTION, SOLUTION	0.20 mg	INTRAMUSCULAR	ANDA	27 sections
Isoproterenol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	14789-011	INJECTION, SOLUTION	0.20 mg	INTRAMUSCULAR	ANDA	27 sections
Isoproterenol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	14789-015	INJECTION, SOLUTION	0.20 mg	INTRAMUSCULAR	ANDA	27 sections
Isoproterenol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	14789-015	INJECTION, SOLUTION	0.20 mg	INTRAMUSCULAR	ANDA	27 sections
Isoproterenol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	14789-015	INJECTION, SOLUTION	0.20 mg	INTRAMUSCULAR	ANDA	27 sections

Showing 1 to 10 of 30 entries

Previous1 2 3Next