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pirbuterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| bronchodilators, phenethylamine derivatives | 2199 | 38677-81-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.20 | mg | Inhal.aerosol |
| 30 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.14 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 60 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PLK1,PLK2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 | 39 | |||
| kinase-selectivity-class | AXL,BRAF,CDK4,EPHB4,GRK2,MAP2K6,TEK | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 30, 1986 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R03AC08 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists |
| ATC | R03CC07 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists |
| FDA MoA | N0000009922 | Adrenergic beta2-Agonists |
| MeSH PA | D000318 | Adrenergic beta-Agonists |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D002316 | Cardiotonic Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D058666 | Adrenergic beta-2 Receptor Agonists |
| FDA EPC | N0000175779 | beta2-Adrenergic Agonist |
| CHEBI has role | CHEBI:65023 | anti-asthmatic agent |
Related Drugs by ATC class:
R03AC Selective beta-2-adrenoreceptor agonists 17 drugs
R03CC Selective beta-2-adrenoreceptor agonists 14 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bronchiectasis | indication | 12295008 | DOID:9563 |
| Disorder of lung | indication | 19829001 | DOID:850 |
| Bronchitis | indication | 32398004 | DOID:6132 |
| Pulmonary emphysema | indication | 87433001 | |
| Asthma | indication | 195967001 | DOID:2841 |
| Asthma management | indication | 406162001 | |
| Acute exacerbation of asthma | indication | 708038006 | |
| Bronchospasm Prevention | indication | ||
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Hypokalemia | contraindication | 43339004 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.36 | acidic |
| pKa2 | 13.79 | acidic |
| pKa3 | 9.38 | Basic |
| pKa4 | 2.77 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019898 | VUID |
| N0000147983 | NUI |
| D00686 | KEGG_DRUG |
| 65652-44-0 | SECONDARY_CAS_RN |
| 4019495 | VANDF |
| 4019898 | VANDF |
| C0071129 | UMLSCUI |
| CHEBI:8245 | CHEBI |
| CHEMBL1094966 | ChEMBL_ID |
| DB01291 | DRUGBANK_ID |
| CHEMBL1200444 | ChEMBL_ID |
| CHEMBL3989646 | ChEMBL_ID |
| 4845 | PUBCHEM_CID |
| C009118 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7272 | IUPHAR_LIGAND_ID |
| 3477 | INN_ID |
| 38029-10-6 | SECONDARY_CAS_RN |
| OG645J8RVW | UNII |
| 221142 | RXNORM |
| 5307 | MMSL |
| d00755 | MMSL |
| 001817 | NDDF |
| 001818 | NDDF |
| 001819 | NDDF |
| 108611006 | SNOMEDCT_US |
| 108612004 | SNOMEDCT_US |
| 372516006 | SNOMEDCT_US |
| OG645J8RVW | INXIGHT DRUGS |
Pharmaceutical products:
None