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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
bambuterol ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
bronchodilators, phenethylamine derivatives
285
81732-65-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
bambuterol
bambudil
terbutaline bisdimethylcarbamate
(+/-)-Bambuterol
bambuterol hydrochloride
bambuterol HCl
selective inhibitor of butyrylcholinesterase & acetylcholinesterase
Molecular weight: 367.45
Formula: C18H29N3O5
CLOGP: 0.74
LIPINSKI: 0
HAC: 8
HDO: 2
TPSA: 91.34
ALOGS: -2.89
ROTB: 8
Drug dosage:
Dose
Unit
Route
20
mg
O
ADMET properties:
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Property
Value
Reference
S (Water solubility)
33 mg/mL
Benet LZ, Broccatelli F, Oprea TI
t_half (Half-life)
2.60 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
18 mL/min/kg
Lombardo F, Berellini G, Obach RS
BA (Bioavailability)
15 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)
1.60 L/kg
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
1
Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)
0.71 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
EoM (Fraction excreted unchanged in urine)
0 %
Benet LZ, Broccatelli F, Oprea TI
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1990
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Acute kidney injury
71.68
58.01
36
274
519368
79224710
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
R03CC12
RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
CHEBI has role
CHEBI:35522
beta-adrenergic agonists
CHEBI has role
CHEBI:35523
bronchodilator
CHEBI has role
CHEBI:35524
sympathomimetic
CHEBI has role
CHEBI:38462
acetylcholinesterase inhibitors
CHEBI has role
CHEBI:49167
anti-asthmatic drugs
CHEBI has role
CHEBI:50266
Prodrugs
CHEBI has role
CHEBI:66993
tocolytic drugs
MeSH PA
D018927
Anti-Asthmatic Agents
MeSH PA
D001993
Bronchodilator Agents
Showing 1 to 10 of 12 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.12
acidic
pKa2
8.92
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Beta-2 adrenergic receptor
GPCR
P07550
ADRB2_HUMAN
WOMBAT-PK
Cytochrome P450 2D6
Enzyme
P10635
CP2D6_HUMAN
IC50
5.70
DRUG MATRIX
Acetylcholinesterase
Enzyme
P22303
ACES_HUMAN
Ki
3.25
WOMBAT-PK
Cholinesterase
Enzyme
P06276
CHLE_HUMAN
INHIBITOR
IC50
8.50
IUPHAR
Butyrylcholinesterase; Protein Bche
Enzyme
Q9JKC1_RAT
IC50
8.52
CHEMBL
Acetylcholinesterase
Enzyme
ACES_RAT
IC50
4.52
CHEMBL
Cholinesterase
Enzyme
CHLE_HORSE
IC50
6.92
CHEMBL
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External reference:
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ID
Source
004156
NDDF
004157
NDDF
18751
RXNORM
349923005
SNOMEDCT_US
391812009
SNOMEDCT_US
396462008
SNOMEDCT_US
5304
INN_ID
54766
PUBCHEM_CID
6601
IUPHAR_LIGAND_ID
81732-46-9
SECONDARY_CAS_RN
Showing 1 to 10 of 17 entries
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Pharmaceutical products:
None
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bambuterol