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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
terbutaline ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
bronchodilators, phenethylamine derivatives
2598
23031-25-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
terbutaline
bricaril
terbutalin
brican
terbutaline sulfate
terbutaline hemisulfate
A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
Molecular weight: 225.29
Formula: C12H19NO3
CLOGP: 0.48
LIPINSKI: 0
HAC: 4
HDO: 4
TPSA: 72.72
ALOGS: -1.59
ROTB: 4
Status: OFP
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
2
mg
Inhal.aerosol
2
mg
Inhal.powder
20
mg
Inhal.solution
15
mg
O
15
mg
P
ADMET properties:
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Property
Value
Reference
EoM (Fraction excreted unchanged in urine)
56 %
Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)
3.40 mL/min/kg
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)
213 mg/mL
Benet LZ, Broccatelli F, Oprea TI
t_half (Half-life)
15 hours
Lombardo F, Berellini G, Obach RS
BA (Bioavailability)
14 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)
1.50 L/kg
Lombardo F, Berellini G, Obach RS
MRTD (Maximum Recommended Therapeutic Daily Dose)
1.11 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma)
0.75 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 9 of 9 entries
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Approvals:
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Date
Agency
Company
Orphan
March 25, 1974
FDA
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Asthma
233.90
16.65
170
8623
127391
63352838
Dyspnoea
114.23
16.65
269
8524
661044
62819185
Wheezing
98.00
16.65
91
8702
95504
63384725
Lactic acidosis
69.87
16.65
51
8742
38236
63441993
Acute kidney injury
58.57
16.65
119
8674
263296
63216933
Sleep disorder due to a general medical condition
55.20
16.65
29
8764
12159
63468070
Sputum discoloured
55.07
16.65
32
8761
16315
63463914
Middle insomnia
54.20
16.65
29
8764
12614
63467615
Nasal discharge discolouration
51.16
16.65
17
8776
2254
63477975
Squamous cell carcinoma of the oral cavity
44.49
16.65
10
8783
302
63479927
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Asthma
143.24
19.00
85
5068
42571
34909207
Wheezing
95.21
19.00
65
5088
41337
34910441
Blood immunoglobulin E increased
76.22
19.00
24
5129
2522
34949256
Cholestasis
65.94
19.00
44
5109
26904
34924874
Chest discomfort
62.93
19.00
57
5096
54473
34897305
Dyspnoea
59.55
19.00
154
4999
376628
34575150
Rhinitis
48.48
19.00
22
5131
6316
34945462
Hyperkaliuria
48.40
19.00
9
5144
95
34951683
Forced expiratory volume decreased
48.04
19.00
18
5135
3185
34948593
Obstructive airways disorder
47.05
19.00
29
5124
15465
34936313
Showing 1 to 10 of 39 entries
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Asthma
248.70
14.98
192
12672
134903
79596621
Wheezing
158.32
14.98
139
12725
116525
79614999
Dyspnoea
122.78
14.98
358
12506
856667
78874857
Cholestasis
82.70
14.98
68
12796
52041
79679483
Forced expiratory volume decreased
76.04
14.98
33
12831
7781
79723743
Lactic acidosis
74.37
14.98
73
12791
70286
79661238
Obstructive airways disorder
67.26
14.98
49
12815
31410
79700114
Middle insomnia
66.67
14.98
38
12826
16031
79715493
Chest discomfort
62.40
14.98
93
12771
137951
79593573
Bronchospasm
58.38
14.98
41
12823
24818
79706706
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โฆ
8
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
R03AC03
RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC
R03CC03
RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
ATC
R03CC53
RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
CHEBI has role
CHEBI:35522
beta-adrenergic agonists
CHEBI has role
CHEBI:35523
bronchodilator
CHEBI has role
CHEBI:35524
sympathomimetic
CHEBI has role
CHEBI:35526
antidiabetic
CHEBI has role
CHEBI:38462
acetylcholinesterase inhibitors
CHEBI has role
CHEBI:49167
anti-asthmatic drugs
CHEBI has role
CHEBI:66993
tocolytic drugs
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Bronchitis
indication
32398004
DOID:6132
Tear film insufficiency
indication
46152009
Pulmonary emphysema
indication
87433001
Asthma
indication
195967001
DOID:2841
Skin irritation
indication
367466007
Asthma management
indication
406162001
Itching of skin
indication
418363000
Acute exacerbation of asthma
indication
708038006
Chronic Obstructive Pulmonary Disease with Bronchospasms
indication
Minor Skin Wound Pain
indication
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.48
acidic
pKa2
11.49
acidic
pKa3
12.74
acidic
pKa4
8.66
Basic
Showing 1 to 4 of 4 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Beta-2 adrenergic receptor
GPCR
P07550
ADRB2_HUMAN
AGONIST
Ki
5.60
WOMBAT-PK
CHEMBL
Beta-2 adrenergic receptor
GPCR
ADRB2_BOVIN
Kd
5.40
CHEMBL
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External reference:
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ID
Source
001812
NDDF
004731
NDDF
10368
RXNORM
23031-32-5
SECONDARY_CAS_RN
24583009
SNOMEDCT_US
2616
INN_ID
372745006
SNOMEDCT_US
4018396
VANDF
4019941
VUID
4019941
VANDF
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
TERBUTALINE SULFATE
HUMAN PRESCRIPTION DRUG LABEL
1
0115-2611
TABLET
2.50 mg
ORAL
ANDA
23 sections
TERBUTALINE SULFATE
HUMAN PRESCRIPTION DRUG LABEL
1
0115-2622
TABLET
5 mg
ORAL
ANDA
23 sections
Terbutaline Sulfate
HUMAN PRESCRIPTION DRUG LABEL
1
0143-9375
INJECTION
1 mg
SUBCUTANEOUS
ANDA
22 sections
Terbutaline Sulfate
HUMAN PRESCRIPTION DRUG LABEL
1
0143-9375
INJECTION
1 mg
SUBCUTANEOUS
ANDA
22 sections
Terbutaline Sulfate
HUMAN PRESCRIPTION DRUG LABEL
1
0143-9746
INJECTION
1 mg
SUBCUTANEOUS
ANDA
22 sections
Terbutaline Sulfate
HUMAN PRESCRIPTION DRUG LABEL
1
0143-9746
INJECTION
1 mg
SUBCUTANEOUS
ANDA
22 sections
Terbutaline Sulfate
HUMAN PRESCRIPTION DRUG LABEL
1
0404-9962
INJECTION, SOLUTION
1 mg
SUBCUTANEOUS
ANDA
11 sections
Terbutaline Sulfate
HUMAN PRESCRIPTION DRUG LABEL
1
0404-9962
INJECTION, SOLUTION
1 mg
SUBCUTANEOUS
ANDA
11 sections
Terbutaline Sulfate
HUMAN PRESCRIPTION DRUG LABEL
1
0404-9962
INJECTION, SOLUTION
1 mg
SUBCUTANEOUS
ANDA
11 sections
Terbutaline Sulfate
HUMAN PRESCRIPTION DRUG LABEL
1
0527-1311
TABLET
5 mg
ORAL
ANDA
23 sections
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terbutaline