reproterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 2368 54063-54-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • reproterol
  • reproterol hydrochloride
  • reproterol HCl
  • reproterol monohydrochloride
  • epiferol
  • Molecular weight: 389.41
  • Formula: C18H23N5O5
  • CLOGP: -0.47
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 4
  • TPSA: 131.16
  • ALOGS: -2.13
  • ROTB: 7

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,ITK,JAK1,JAK2,KDR,KIT,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PIK3CB,PIK3CD,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2,ZAP70 61
kinase-selectivity-class GRK2,MAPK7,PRKDC,TEK 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AC15 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03AK05 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03CC14 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D000322 Adrenergic Agonists
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:65023 anti-asthmatic agent

Related Drugs by ATC class:

R03AC Selective beta-2-adrenoreceptor agonists 17 drugs
bitolterolcarbuterolclenbuterolfenoterolformoterolhexoprenalineindacaterolisoetarineolodaterolpirbuterolprocaterolrimiterol show all 17 →
R03AK Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics 13 drugs
beclometasone dipropionatebudesonidecromoglicic acidepinephrinefluticasone furoatefluticasone propionateformoterolindacaterolisoprenalinemometasone furoatesalbutamolsalmeterol show all 13 →
R03CC Selective beta-2-adrenoreceptor agonists 14 drugs
ambroxolbambuterolcarbuterolclenbuterolfenoterolformoterolhexoprenalineisoetarinepirbuterolprocaterolsalbutamolterbutaline show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Asthma indication 195967001 DOID:2841




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.48 acidic
pKa2 11.49 acidic
pKa3 12.44 acidic
pKa4 7.49 Basic
pKa5 2.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D05718 KEGG_DRUG
C0073076 UMLSCUI
CHEBI:135612 CHEBI
CHEMBL1095607 ChEMBL_ID
DB12846 DRUGBANK_ID
CHEMBL2104771 ChEMBL_ID
C014792 MESH_SUPPLEMENTAL_RECORD_UI
25654 PUBCHEM_CID
3501 INN_ID
13055-82-8 SECONDARY_CAS_RN
11941YC6RN UNII
235833 RXNORM
004033 NDDF
004034 NDDF
349925003 SNOMEDCT_US
396465005 SNOMEDCT_US
11941YC6RN INXIGHT DRUGS

Pharmaceutical products:

None