Stem definition | Drug id | CAS RN |
---|---|---|
bronchodilators, phenethylamine derivatives | 2419 | 89365-50-4 |
Dose | Unit | Route |
---|---|---|
0.10 | mg | Inhal.aerosol |
0.10 | mg | Inhal.powder |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.00 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
March 26, 2021 | EMA | TEVA B.V. | |
Feb. 4, 1994 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 2780.95 | 9.92 | 1924 | 92524 | 89618 | 46501996 |
Wheezing | 874.56 | 9.92 | 781 | 93667 | 52605 | 46539009 |
Chronic obstructive pulmonary disease | 680.28 | 9.92 | 704 | 93744 | 56929 | 46534685 |
Dyspnoea | 662.37 | 9.92 | 2411 | 92037 | 513137 | 46078477 |
Obstructive airways disorder | 382.42 | 9.92 | 272 | 94176 | 13140 | 46578474 |
Cough | 368.61 | 9.92 | 1162 | 93286 | 229087 | 46362527 |
Forced expiratory volume decreased | 350.71 | 9.92 | 182 | 94266 | 4922 | 46586692 |
Productive cough | 348.61 | 9.92 | 470 | 93978 | 50245 | 46541369 |
Sputum discoloured | 290.08 | 9.92 | 226 | 94222 | 12552 | 46579062 |
Completed suicide | 245.20 | 9.92 | 12 | 94436 | 145908 | 46445706 |
Pneumonia | 228.19 | 9.92 | 1419 | 93029 | 374901 | 46216713 |
Chest discomfort | 223.33 | 9.92 | 535 | 93913 | 89734 | 46501880 |
Bronchitis | 190.76 | 9.92 | 558 | 93890 | 105421 | 46486193 |
Temperature regulation disorder | 178.40 | 9.92 | 101 | 94347 | 3259 | 46588355 |
Product quality issue | 172.17 | 9.92 | 280 | 94168 | 35368 | 46556246 |
Eosinophilic granulomatosis with polyangiitis | 163.22 | 9.92 | 78 | 94370 | 1758 | 46589856 |
Toxicity to various agents | 152.42 | 9.92 | 123 | 94325 | 211643 | 46379971 |
Blood count abnormal | 148.36 | 9.92 | 182 | 94266 | 17696 | 46573918 |
Food allergy | 143.15 | 9.92 | 116 | 94332 | 6817 | 46584797 |
Middle insomnia | 130.04 | 9.92 | 126 | 94322 | 9389 | 46582225 |
Immunodeficiency | 124.57 | 9.92 | 143 | 94305 | 12963 | 46578651 |
Upper respiratory tract infection | 124.35 | 9.92 | 345 | 94103 | 63211 | 46528403 |
Coeliac disease | 123.49 | 9.92 | 108 | 94340 | 7053 | 46584561 |
Malaise | 121.34 | 9.92 | 1110 | 93338 | 330122 | 46261492 |
Infective pulmonary exacerbation of cystic fibrosis | 116.61 | 9.92 | 126 | 94322 | 10681 | 46580933 |
Breath sounds abnormal | 111.55 | 9.92 | 106 | 94342 | 7709 | 46583905 |
Nasal congestion | 105.02 | 9.92 | 272 | 94176 | 47841 | 46543773 |
Dyspnoea exertional | 100.35 | 9.92 | 275 | 94173 | 50014 | 46541600 |
Lower respiratory tract infection | 99.91 | 9.92 | 291 | 94157 | 54798 | 46536816 |
Dysphonia | 97.40 | 9.92 | 230 | 94218 | 38184 | 46553430 |
Drug abuse | 95.44 | 9.92 | 9 | 94439 | 63399 | 46528215 |
Treatment failure | 94.55 | 9.92 | 35 | 94413 | 93052 | 46498562 |
Off label use | 93.55 | 9.92 | 423 | 94025 | 379418 | 46212196 |
Neutropenia | 91.24 | 9.92 | 93 | 94355 | 143111 | 46448503 |
Synovitis | 86.02 | 9.92 | 11 | 94437 | 61064 | 46530550 |
Lung disorder | 85.60 | 9.92 | 236 | 94212 | 43068 | 46548546 |
Blood immunoglobulin E increased | 85.34 | 9.92 | 50 | 94398 | 1723 | 46589891 |
Influenza | 84.24 | 9.92 | 381 | 94067 | 88889 | 46502725 |
Febrile neutropenia | 82.85 | 9.92 | 44 | 94404 | 94583 | 46497031 |
Respiratory tract congestion | 82.64 | 9.92 | 115 | 94333 | 12649 | 46578965 |
Sinusitis | 82.38 | 9.92 | 496 | 93952 | 129272 | 46462342 |
Pulmonary function test decreased | 76.94 | 9.92 | 63 | 94385 | 3757 | 46587857 |
Intentional overdose | 75.71 | 9.92 | 19 | 94429 | 64925 | 46526689 |
Nasal polyps | 72.80 | 9.92 | 49 | 94399 | 2161 | 46589453 |
Pancytopenia | 70.94 | 9.92 | 42 | 94406 | 85016 | 46506598 |
Thrombocytopenia | 64.08 | 9.92 | 98 | 94350 | 126483 | 46465131 |
Eosinophil count increased | 63.52 | 9.92 | 79 | 94369 | 7787 | 46583827 |
Heart rate increased | 63.08 | 9.92 | 309 | 94139 | 74482 | 46517132 |
Oxygen saturation decreased | 62.86 | 9.92 | 292 | 94156 | 68872 | 46522742 |
Sleep disorder due to a general medical condition | 62.81 | 9.92 | 54 | 94394 | 3445 | 46588169 |
Forced vital capacity decreased | 61.32 | 9.92 | 32 | 94416 | 875 | 46590739 |
Bronchospasm | 60.91 | 9.92 | 112 | 94336 | 15595 | 46576019 |
Bursitis | 60.61 | 9.92 | 128 | 94320 | 19714 | 46571900 |
Rash erythematous | 59.92 | 9.92 | 179 | 94269 | 34171 | 46557443 |
Nasopharyngitis | 59.72 | 9.92 | 523 | 93925 | 153475 | 46438139 |
Malignant neoplasm progression | 58.60 | 9.92 | 29 | 94419 | 64897 | 46526717 |
Hand deformity | 57.52 | 9.92 | 3 | 94445 | 34571 | 46557043 |
Hypersensitivity | 57.50 | 9.92 | 509 | 93939 | 149812 | 46441802 |
Asthmatic crisis | 56.57 | 9.92 | 36 | 94412 | 1442 | 46590172 |
Emphysema | 56.27 | 9.92 | 80 | 94368 | 8974 | 46582640 |
Systemic lupus erythematosus | 56.04 | 9.92 | 31 | 94417 | 65149 | 46526465 |
Secretion discharge | 55.16 | 9.92 | 80 | 94368 | 9139 | 46582475 |
Oropharyngeal pain | 54.59 | 9.92 | 295 | 94153 | 73873 | 46517741 |
Fluid retention | 54.35 | 9.92 | 226 | 94222 | 50820 | 46540794 |
Rales | 53.92 | 9.92 | 81 | 94367 | 9550 | 46582064 |
Asphyxia | 53.82 | 9.92 | 60 | 94388 | 5266 | 46586348 |
Rheumatoid arthritis | 53.49 | 9.92 | 277 | 94171 | 239938 | 46351676 |
Peak expiratory flow rate decreased | 53.49 | 9.92 | 26 | 94422 | 609 | 46591005 |
Haemoptysis | 53.01 | 9.92 | 144 | 94304 | 26045 | 46565569 |
Seasonal allergy | 52.87 | 9.92 | 96 | 94352 | 13238 | 46578376 |
Bronchial wall thickening | 52.44 | 9.92 | 28 | 94420 | 803 | 46590811 |
Therapeutic product effect incomplete | 51.66 | 9.92 | 302 | 94146 | 77851 | 46513763 |
Hypoventilation | 49.83 | 9.92 | 51 | 94397 | 4059 | 46587555 |
Bronchiectasis | 48.84 | 9.92 | 76 | 94372 | 9240 | 46582374 |
Drug ineffective | 47.72 | 9.92 | 1028 | 93420 | 676810 | 45914804 |
Rhinorrhoea | 47.62 | 9.92 | 207 | 94241 | 47458 | 46544156 |
Eye pruritus | 47.60 | 9.92 | 86 | 94362 | 11812 | 46579802 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 47.23 | 9.92 | 22 | 94426 | 467 | 46591147 |
Inhalation therapy | 46.65 | 9.92 | 13 | 94435 | 53 | 46591561 |
Drug intolerance | 46.28 | 9.92 | 148 | 94300 | 146901 | 46444713 |
Status asthmaticus | 44.01 | 9.92 | 26 | 94422 | 910 | 46590704 |
Lung neoplasm malignant | 43.97 | 9.92 | 97 | 94351 | 15392 | 46576222 |
Cystic fibrosis | 43.33 | 9.92 | 45 | 94403 | 3643 | 46587971 |
Prolonged expiration | 42.62 | 9.92 | 19 | 94429 | 363 | 46591251 |
Anaemia | 41.96 | 9.92 | 324 | 94124 | 255455 | 46336159 |
Death | 41.66 | 9.92 | 456 | 93992 | 335092 | 46256522 |
Alopecia | 40.97 | 9.92 | 179 | 94269 | 162235 | 46429379 |
Blood pressure systolic increased | 40.19 | 9.92 | 139 | 94309 | 28648 | 46562966 |
Rhinitis allergic | 39.96 | 9.92 | 59 | 94389 | 6849 | 46584765 |
Smoke sensitivity | 38.93 | 9.92 | 16 | 94432 | 248 | 46591366 |
Reversible airways obstruction | 38.69 | 9.92 | 20 | 94428 | 536 | 46591078 |
Adrenal insufficiency | 38.17 | 9.92 | 83 | 94365 | 13041 | 46578573 |
Aphonia | 37.78 | 9.92 | 62 | 94386 | 7883 | 46583731 |
Sputum retention | 37.65 | 9.92 | 18 | 94430 | 406 | 46591208 |
Rhonchi | 37.38 | 9.92 | 33 | 94415 | 2182 | 46589432 |
Increased viscosity of bronchial secretion | 37.01 | 9.92 | 16 | 94432 | 283 | 46591331 |
Respiratory tract infection | 36.98 | 9.92 | 139 | 94309 | 29833 | 46561781 |
Increased upper airway secretion | 36.92 | 9.92 | 39 | 94409 | 3220 | 46588394 |
Maternal exposure during pregnancy | 36.78 | 9.92 | 97 | 94351 | 102452 | 46489162 |
Diarrhoea | 35.53 | 9.92 | 862 | 93586 | 558740 | 46032874 |
Glossodynia | 35.47 | 9.92 | 23 | 94425 | 44350 | 46547264 |
Leukopenia | 35.45 | 9.92 | 52 | 94396 | 68291 | 46523323 |
Alanine aminotransferase increased | 35.40 | 9.92 | 79 | 94369 | 88372 | 46503242 |
White blood cell count decreased | 34.57 | 9.92 | 114 | 94334 | 112117 | 46479497 |
Respiratory rate increased | 34.05 | 9.92 | 73 | 94375 | 11360 | 46580254 |
Lung hyperinflation | 33.98 | 9.92 | 24 | 94424 | 1145 | 46590469 |
Infective exacerbation of chronic obstructive airways disease | 33.78 | 9.92 | 24 | 94424 | 1156 | 46590458 |
Respiratory symptom | 33.26 | 9.92 | 30 | 94418 | 2040 | 46589574 |
Pulmonary mass | 33.00 | 9.92 | 95 | 94353 | 17762 | 46573852 |
Eosinophil count abnormal | 32.94 | 9.92 | 17 | 94431 | 454 | 46591160 |
Rhinitis | 32.72 | 9.92 | 58 | 94390 | 7848 | 46583766 |
Spirometry abnormal | 32.51 | 9.92 | 13 | 94435 | 187 | 46591427 |
Joint swelling | 32.33 | 9.92 | 200 | 94248 | 165873 | 46425741 |
Oral candidiasis | 32.14 | 9.92 | 93 | 94355 | 17439 | 46574175 |
Lower respiratory tract congestion | 31.95 | 9.92 | 28 | 94420 | 1833 | 46589781 |
Hepatotoxicity | 31.81 | 9.92 | 6 | 94442 | 25003 | 46566611 |
Acute respiratory failure | 31.79 | 9.92 | 130 | 94318 | 29008 | 46562606 |
Contraindicated product administered | 30.71 | 9.92 | 73 | 94375 | 79874 | 46511740 |
Eosinophilic pneumonia chronic | 30.69 | 9.92 | 10 | 94438 | 76 | 46591538 |
Platelet count decreased | 30.53 | 9.92 | 102 | 94346 | 99922 | 46491692 |
Serotonin syndrome | 30.41 | 9.92 | 6 | 94442 | 24214 | 46567400 |
Humidity intolerance | 30.19 | 9.92 | 15 | 94433 | 369 | 46591245 |
Nocturnal dyspnoea | 29.96 | 9.92 | 21 | 94427 | 990 | 46590624 |
Respiratory disorder | 29.94 | 9.92 | 122 | 94326 | 27178 | 46564436 |
Arthropathy | 29.70 | 9.92 | 81 | 94367 | 84619 | 46506995 |
Atopy | 29.62 | 9.92 | 12 | 94436 | 179 | 46591435 |
Pulmonary function test abnormal | 29.59 | 9.92 | 23 | 94425 | 1272 | 46590342 |
C-reactive protein abnormal | 29.54 | 9.92 | 4 | 94444 | 21266 | 46570348 |
Bronchial disorder | 29.51 | 9.92 | 21 | 94427 | 1014 | 46590600 |
Aspartate aminotransferase increased | 29.33 | 9.92 | 73 | 94375 | 78627 | 46512987 |
Sensitivity to weather change | 28.91 | 9.92 | 45 | 94403 | 5471 | 46586143 |
Sputum purulent | 28.49 | 9.92 | 19 | 94429 | 825 | 46590789 |
Upper-airway cough syndrome | 27.99 | 9.92 | 54 | 94394 | 7793 | 46583821 |
Coma | 27.79 | 9.92 | 47 | 94401 | 58302 | 46533312 |
Viral infection | 27.71 | 9.92 | 128 | 94320 | 30107 | 46561507 |
Nasal discharge discolouration | 27.33 | 9.92 | 23 | 94425 | 1425 | 46590189 |
Neurosensory hypoacusis | 27.08 | 9.92 | 13 | 94435 | 296 | 46591318 |
Gastrooesophageal reflux disease | 26.99 | 9.92 | 249 | 94199 | 74095 | 46517519 |
Device expulsion | 26.88 | 9.92 | 11 | 94437 | 27531 | 46564083 |
Musculoskeletal stiffness | 26.56 | 9.92 | 105 | 94343 | 97888 | 46493726 |
Throat irritation | 26.23 | 9.92 | 122 | 94326 | 28779 | 46562835 |
Hypercapnia | 26.03 | 9.92 | 39 | 94409 | 4587 | 46587027 |
Total lung capacity decreased | 26.00 | 9.92 | 20 | 94428 | 1089 | 46590525 |
Infusion related reaction | 25.84 | 9.92 | 111 | 94337 | 101097 | 46490517 |
Sneezing | 25.72 | 9.92 | 70 | 94378 | 12671 | 46578943 |
Magnetic resonance imaging thoracic abnormal | 25.43 | 9.92 | 7 | 94441 | 27 | 46591587 |
Body temperature decreased | 25.42 | 9.92 | 72 | 94376 | 13337 | 46578277 |
C-reactive protein increased | 25.40 | 9.92 | 50 | 94398 | 58540 | 46533074 |
Therapeutic product effect decreased | 25.37 | 9.92 | 84 | 94364 | 82517 | 46509097 |
Disease progression | 25.27 | 9.92 | 97 | 94351 | 91203 | 46500411 |
Eosinophilic oesophagitis | 25.17 | 9.92 | 11 | 94437 | 200 | 46591414 |
Total lung capacity increased | 25.11 | 9.92 | 17 | 94431 | 757 | 46590857 |
Cardio-respiratory arrest | 24.34 | 9.92 | 53 | 94395 | 59816 | 46531798 |
Perfume sensitivity | 24.30 | 9.92 | 15 | 94433 | 569 | 46591045 |
Red blood cell sedimentation rate increased | 24.27 | 9.92 | 8 | 94440 | 22881 | 46568733 |
Chest pain | 23.99 | 9.92 | 495 | 93953 | 175829 | 46415785 |
Eye infection bacterial | 23.98 | 9.92 | 9 | 94439 | 108 | 46591506 |
Lactic acidosis | 23.96 | 9.92 | 20 | 94428 | 33889 | 46557725 |
Hyposmia | 23.85 | 9.92 | 13 | 94435 | 389 | 46591225 |
Cytomegalovirus infection | 23.85 | 9.92 | 4 | 94444 | 18140 | 46573474 |
Laryngitis | 23.84 | 9.92 | 56 | 94392 | 9260 | 46582354 |
Dizziness | 23.63 | 9.92 | 876 | 93572 | 339538 | 46252076 |
Bronchial neoplasm | 23.42 | 9.92 | 11 | 94437 | 238 | 46591376 |
Rash | 23.42 | 9.92 | 546 | 93902 | 355966 | 46235648 |
Increased bronchial secretion | 23.24 | 9.92 | 22 | 94426 | 1592 | 46590022 |
Urticaria | 23.20 | 9.92 | 351 | 94097 | 117541 | 46474073 |
Dust allergy | 23.09 | 9.92 | 14 | 94434 | 514 | 46591100 |
Nasal turbinate hypertrophy | 23.06 | 9.92 | 13 | 94435 | 416 | 46591198 |
Lung diffusion test decreased | 22.87 | 9.92 | 15 | 94433 | 633 | 46590981 |
Bronchial haemorrhage | 22.83 | 9.92 | 12 | 94436 | 333 | 46591281 |
Lipohypertrophy | 22.79 | 9.92 | 16 | 94432 | 756 | 46590858 |
Neutrophil count decreased | 22.56 | 9.92 | 33 | 94415 | 43393 | 46548221 |
Product use in unapproved indication | 22.44 | 9.92 | 100 | 94348 | 90173 | 46501441 |
Influenza B virus test positive | 22.17 | 9.92 | 12 | 94436 | 354 | 46591260 |
Arteriosclerosis coronary artery | 21.94 | 9.92 | 50 | 94398 | 8106 | 46583508 |
Sputum increased | 21.67 | 9.92 | 22 | 94426 | 1734 | 46589880 |
Hyperhidrosis | 21.67 | 9.92 | 276 | 94172 | 89032 | 46502582 |
Immune-mediated pancreatitis | 21.62 | 9.92 | 7 | 94441 | 52 | 46591562 |
Drug reaction with eosinophilia and systemic symptoms | 21.41 | 9.92 | 17 | 94431 | 29531 | 46562083 |
Eosinophilic bronchitis | 21.41 | 9.92 | 11 | 94437 | 291 | 46591323 |
Disseminated intravascular coagulation | 21.31 | 9.92 | 6 | 94442 | 18999 | 46572615 |
Hepatic function abnormal | 21.17 | 9.92 | 23 | 94425 | 34398 | 46557216 |
Multiple organ dysfunction syndrome | 20.84 | 9.92 | 46 | 94402 | 51664 | 46539950 |
Headache | 20.80 | 9.92 | 1174 | 93274 | 477178 | 46114436 |
Throat clearing | 20.73 | 9.92 | 12 | 94436 | 404 | 46591210 |
Cortisol decreased | 20.57 | 9.92 | 17 | 94431 | 1027 | 46590587 |
Paranasal sinus discomfort | 20.56 | 9.92 | 26 | 94422 | 2606 | 46589008 |
Decreased bronchial secretion | 20.45 | 9.92 | 7 | 94441 | 63 | 46591551 |
Heart sounds | 20.24 | 9.92 | 10 | 94438 | 243 | 46591371 |
Palmar-plantar erythrodysaesthesia syndrome | 20.23 | 9.92 | 8 | 94440 | 20443 | 46571171 |
Restrictive pulmonary disease | 20.16 | 9.92 | 18 | 94430 | 1208 | 46590406 |
Hepatic failure | 19.82 | 9.92 | 23 | 94425 | 33393 | 46558221 |
Sinus congestion | 19.80 | 9.92 | 65 | 94383 | 13044 | 46578570 |
Respiration abnormal | 19.79 | 9.92 | 34 | 94414 | 4487 | 46587127 |
Neoplasm progression | 19.78 | 9.92 | 15 | 94433 | 26668 | 46564946 |
Suicide attempt | 19.77 | 9.92 | 52 | 94396 | 54984 | 46536630 |
Accidental exposure to product | 19.65 | 9.92 | 9 | 94439 | 21072 | 46570542 |
Respiratory arrest | 19.28 | 9.92 | 24 | 94424 | 33792 | 46557822 |
Exposure during pregnancy | 19.18 | 9.92 | 134 | 94314 | 108078 | 46483536 |
Bone marrow failure | 19.18 | 9.92 | 19 | 94429 | 29650 | 46561964 |
Septic shock | 19.09 | 9.92 | 57 | 94391 | 57836 | 46533778 |
Weight decreased | 19.08 | 9.92 | 560 | 93888 | 210289 | 46381325 |
Bronchial obstruction | 19.00 | 9.92 | 18 | 94430 | 1304 | 46590310 |
Encephalopathy | 18.98 | 9.92 | 24 | 94424 | 33565 | 46558049 |
Conjunctivitis allergic | 18.95 | 9.92 | 14 | 94434 | 717 | 46590897 |
Choking | 18.93 | 9.92 | 48 | 94400 | 8328 | 46583286 |
Functional residual capacity increased | 18.73 | 9.92 | 7 | 94441 | 83 | 46591531 |
Perineal fistula | 18.72 | 9.92 | 6 | 94442 | 43 | 46591571 |
Hypotension | 18.56 | 9.92 | 345 | 94103 | 232244 | 46359370 |
Seizure | 18.26 | 9.92 | 160 | 94288 | 122894 | 46468720 |
Cognitive disorder | 18.22 | 9.92 | 29 | 94419 | 36854 | 46554760 |
Dyskinesia | 18.15 | 9.92 | 19 | 94429 | 28906 | 46562708 |
Premature baby | 18.06 | 9.92 | 7 | 94441 | 18105 | 46573509 |
Bronchial secretion retention | 17.84 | 9.92 | 15 | 94433 | 928 | 46590686 |
Bronchitis chronic | 17.80 | 9.92 | 31 | 94417 | 4136 | 46587478 |
Acute hepatic failure | 17.75 | 9.92 | 4 | 94444 | 14717 | 46576897 |
Intentional self-injury | 17.39 | 9.92 | 14 | 94434 | 24152 | 46567462 |
Bradycardia | 17.35 | 9.92 | 72 | 94376 | 66226 | 46525388 |
Thyroid atrophy | 17.29 | 9.92 | 5 | 94443 | 24 | 46591590 |
Renal failure | 17.16 | 9.92 | 147 | 94301 | 113447 | 46478167 |
Oropharyngitis fungal | 17.15 | 9.92 | 6 | 94442 | 58 | 46591556 |
Impaired healing | 17.12 | 9.92 | 30 | 94418 | 36713 | 46554901 |
Fungal endocarditis | 17.12 | 9.92 | 9 | 94439 | 250 | 46591364 |
Product administration error | 17.07 | 9.92 | 82 | 94366 | 19599 | 46572015 |
Ascites | 16.93 | 9.92 | 30 | 94418 | 36554 | 46555060 |
Sarcoidosis | 16.59 | 9.92 | 34 | 94414 | 5125 | 46586489 |
Drug interaction | 16.59 | 9.92 | 300 | 94148 | 202794 | 46388820 |
Aspirin-exacerbated respiratory disease | 16.47 | 9.92 | 13 | 94435 | 735 | 46590879 |
Peak expiratory flow rate abnormal | 16.45 | 9.92 | 7 | 94441 | 119 | 46591495 |
Anaphylactic reaction | 16.39 | 9.92 | 172 | 94276 | 52940 | 46538674 |
Otorrhoea | 16.20 | 9.92 | 17 | 94431 | 1393 | 46590221 |
Stomatitis | 16.17 | 9.92 | 77 | 94371 | 68220 | 46523394 |
Back pain | 16.14 | 9.92 | 547 | 93901 | 209492 | 46382122 |
Sepsis | 15.97 | 9.92 | 187 | 94261 | 135827 | 46455787 |
Hyperkalaemia | 15.96 | 9.92 | 51 | 94397 | 50658 | 46540956 |
Functional residual capacity decreased | 15.91 | 9.92 | 6 | 94442 | 73 | 46591541 |
Granuloma | 15.89 | 9.92 | 28 | 94420 | 3770 | 46587844 |
Trifascicular block | 15.88 | 9.92 | 7 | 94441 | 130 | 46591484 |
Dysmetropsia | 15.77 | 9.92 | 6 | 94442 | 75 | 46591539 |
Adrenal suppression | 15.71 | 9.92 | 14 | 94434 | 937 | 46590677 |
Pulmonary pain | 15.44 | 9.92 | 18 | 94430 | 1658 | 46589956 |
Drug resistance | 15.30 | 9.92 | 8 | 94440 | 17360 | 46574254 |
Shock | 15.29 | 9.92 | 13 | 94435 | 21832 | 46569782 |
Type 2 diabetes mellitus | 15.25 | 9.92 | 80 | 94368 | 19795 | 46571819 |
Plasma cell myeloma | 15.24 | 9.92 | 43 | 94405 | 44435 | 46547179 |
Respiratory tract irritation | 15.16 | 9.92 | 10 | 94438 | 426 | 46591188 |
Abdominal discomfort | 15.11 | 9.92 | 215 | 94233 | 150950 | 46440664 |
Blood test abnormal | 15.10 | 9.92 | 48 | 94400 | 9472 | 46582142 |
Pneumocystis jirovecii pneumonia | 15.03 | 9.92 | 6 | 94442 | 15242 | 46576372 |
Vital capacity decreased | 14.98 | 9.92 | 11 | 94437 | 558 | 46591056 |
Psoriatic arthropathy | 14.95 | 9.92 | 32 | 94416 | 36347 | 46555267 |
Peritonitis | 14.90 | 9.92 | 12 | 94436 | 20702 | 46570912 |
Sopor | 14.89 | 9.92 | 11 | 94437 | 19817 | 46571797 |
Bronchitis bacterial | 14.88 | 9.92 | 12 | 94436 | 700 | 46590914 |
Dehydration | 14.87 | 9.92 | 230 | 94218 | 159310 | 46432304 |
Blood creatinine increased | 14.85 | 9.92 | 92 | 94356 | 76311 | 46515303 |
Chronic sinusitis | 14.83 | 9.92 | 32 | 94416 | 5001 | 46586613 |
Exposure to allergen | 14.80 | 9.92 | 7 | 94441 | 154 | 46591460 |
Nasal oedema | 14.73 | 9.92 | 13 | 94435 | 859 | 46590755 |
Generalised tonic-clonic seizure | 14.69 | 9.92 | 20 | 94428 | 27102 | 46564512 |
Poisoning | 14.64 | 9.92 | 5 | 94443 | 13989 | 46577625 |
Mucosal inflammation | 14.64 | 9.92 | 36 | 94412 | 38940 | 46552674 |
Eczema impetiginous | 14.62 | 9.92 | 4 | 94444 | 15 | 46591599 |
Pneumonia aspiration | 14.55 | 9.92 | 26 | 94422 | 31579 | 46560035 |
Metastases to liver | 14.53 | 9.92 | 11 | 94437 | 19574 | 46572040 |
Nasal mucosal discolouration | 14.42 | 9.92 | 4 | 94444 | 16 | 46591598 |
Premature delivery | 14.42 | 9.92 | 14 | 94434 | 22055 | 46569559 |
Bronchopulmonary aspergillosis allergic | 14.39 | 9.92 | 12 | 94436 | 734 | 46590880 |
Small airways disease | 14.22 | 9.92 | 4 | 94444 | 17 | 46591597 |
Allergy to animal | 14.17 | 9.92 | 11 | 94437 | 607 | 46591007 |
Investigation | 14.15 | 9.92 | 17 | 94431 | 1617 | 46589997 |
Hyperplastic cholecystopathy | 14.10 | 9.92 | 6 | 94442 | 102 | 46591512 |
Breast conserving surgery | 13.78 | 9.92 | 12 | 94436 | 779 | 46590835 |
Nasal mucosal disorder | 13.53 | 9.92 | 9 | 94439 | 389 | 46591225 |
Tobacco abuse | 13.42 | 9.92 | 11 | 94437 | 657 | 46590957 |
Chronic respiratory failure | 13.26 | 9.92 | 17 | 94431 | 1727 | 46589887 |
Nasal obstruction | 13.25 | 9.92 | 11 | 94437 | 669 | 46590945 |
Foetal malnutrition | 13.21 | 9.92 | 6 | 94442 | 120 | 46591494 |
Eosinophilia | 13.17 | 9.92 | 75 | 94373 | 19142 | 46572472 |
Endometrial ablation | 12.97 | 9.92 | 11 | 94437 | 689 | 46590925 |
Acute myeloid leukaemia | 12.85 | 9.92 | 8 | 94440 | 15770 | 46575844 |
Myelodysplastic syndrome | 12.75 | 9.92 | 8 | 94440 | 15703 | 46575911 |
Infective aneurysm | 12.75 | 9.92 | 9 | 94439 | 429 | 46591185 |
Osteonecrosis of jaw | 12.74 | 9.92 | 32 | 94416 | 34370 | 46557244 |
Foetal exposure during pregnancy | 12.68 | 9.92 | 27 | 94421 | 30720 | 46560894 |
Psoriasis | 12.65 | 9.92 | 100 | 94348 | 78504 | 46513110 |
Pericarditis | 12.60 | 9.92 | 18 | 94430 | 23909 | 46567705 |
Varicella zoster oesophagitis | 12.56 | 9.92 | 4 | 94444 | 28 | 46591586 |
Injection site reaction | 12.50 | 9.92 | 52 | 94396 | 47797 | 46543817 |
Drug ineffective for unapproved indication | 12.46 | 9.92 | 9 | 94439 | 16404 | 46575210 |
Gait deviation | 12.38 | 9.92 | 5 | 94443 | 74 | 46591540 |
Adverse drug reaction | 12.36 | 9.92 | 47 | 94401 | 44315 | 46547299 |
Haemoglobin decreased | 12.32 | 9.92 | 185 | 94263 | 128764 | 46462850 |
Faecal volume decreased | 12.17 | 9.92 | 6 | 94442 | 145 | 46591469 |
Gamma-glutamyltransferase increased | 12.17 | 9.92 | 29 | 94419 | 31711 | 46559903 |
Palpitations | 12.15 | 9.92 | 265 | 94183 | 94994 | 46496620 |
Muscle spasticity | 12.12 | 9.92 | 4 | 94444 | 11436 | 46580178 |
Osteochondritis | 12.10 | 9.92 | 4 | 94444 | 32 | 46591582 |
Breast neoplasm | 12.08 | 9.92 | 14 | 94434 | 1281 | 46590333 |
Varicella zoster gastritis | 11.99 | 9.92 | 4 | 94444 | 33 | 46591581 |
Liver injury | 11.85 | 9.92 | 9 | 94439 | 15992 | 46575622 |
Crepitations | 11.83 | 9.92 | 33 | 94415 | 6059 | 46585555 |
Sputum abnormal | 11.82 | 9.92 | 8 | 94440 | 356 | 46591258 |
Sinus headache | 11.75 | 9.92 | 28 | 94420 | 4672 | 46586942 |
Hypothermia | 11.67 | 9.92 | 5 | 94443 | 12178 | 46579436 |
Abortion spontaneous | 11.67 | 9.92 | 47 | 94401 | 43599 | 46548015 |
Neuroleptic malignant syndrome | 11.59 | 9.92 | 4 | 94444 | 11118 | 46580496 |
Illness | 11.38 | 9.92 | 52 | 94396 | 12172 | 46579442 |
Stress fracture | 11.36 | 9.92 | 36 | 94412 | 7091 | 46584523 |
Gastroenteritis eosinophilic | 11.29 | 9.92 | 5 | 94443 | 94 | 46591520 |
Pneumonectomy | 11.24 | 9.92 | 3 | 94445 | 10 | 46591604 |
Haemolytic anaemia | 11.23 | 9.92 | 3 | 94445 | 9839 | 46581775 |
Blood lactate dehydrogenase increased | 11.22 | 9.92 | 15 | 94433 | 20485 | 46571129 |
Symptom recurrence | 11.21 | 9.92 | 8 | 94440 | 388 | 46591226 |
Influenza like illness | 11.16 | 9.92 | 171 | 94277 | 57399 | 46534215 |
No adverse event | 11.07 | 9.92 | 34 | 94414 | 34197 | 46557417 |
Depressed level of consciousness | 11.04 | 9.92 | 54 | 94394 | 47515 | 46544099 |
Bronchospasm paradoxical | 10.96 | 9.92 | 5 | 94443 | 101 | 46591513 |
Overdose | 10.92 | 9.92 | 143 | 94305 | 101836 | 46489778 |
Transplant rejection | 10.81 | 9.92 | 3 | 94445 | 9593 | 46582021 |
Tracheobronchitis bacterial | 10.81 | 9.92 | 3 | 94445 | 12 | 46591602 |
Cerebral haemorrhage | 10.81 | 9.92 | 26 | 94422 | 28345 | 46563269 |
Infusion site erythema | 10.75 | 9.92 | 37 | 94411 | 7605 | 46584009 |
Throat tightness | 10.69 | 9.92 | 75 | 94373 | 20564 | 46571050 |
Mydriasis | 10.65 | 9.92 | 4 | 94444 | 10549 | 46581065 |
FEV1/FVC ratio decreased | 10.62 | 9.92 | 3 | 94445 | 13 | 46591601 |
Nasal pruritus | 10.62 | 9.92 | 7 | 94441 | 298 | 46591316 |
Peroneal nerve injury | 10.51 | 9.92 | 4 | 94444 | 50 | 46591564 |
Candida infection | 10.47 | 9.92 | 79 | 94369 | 22161 | 46569453 |
Renal impairment | 10.46 | 9.92 | 98 | 94350 | 74274 | 46517340 |
Nausea | 10.44 | 9.92 | 1225 | 93223 | 686229 | 45905385 |
Cor pulmonale | 10.39 | 9.92 | 16 | 94432 | 1927 | 46589687 |
Drug eruption | 10.32 | 9.92 | 17 | 94431 | 21312 | 46570302 |
Blood pressure fluctuation | 10.02 | 9.92 | 30 | 94418 | 30418 | 46561196 |
Bacillus infection | 9.99 | 9.92 | 7 | 94441 | 330 | 46591284 |
Erythema | 9.98 | 9.92 | 368 | 94080 | 142452 | 46449162 |
Ejection fraction decreased | 9.95 | 9.92 | 13 | 94435 | 17924 | 46573690 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 1647.26 | 10.81 | 913 | 48346 | 35261 | 29867958 |
Chronic obstructive pulmonary disease | 635.73 | 10.81 | 559 | 48700 | 45567 | 29857652 |
Wheezing | 527.29 | 10.81 | 424 | 48835 | 30514 | 29872705 |
Dyspnoea | 398.88 | 10.81 | 1325 | 47934 | 331970 | 29571249 |
Obstructive airways disorder | 390.35 | 10.81 | 221 | 49038 | 8838 | 29894381 |
Cough | 269.63 | 10.81 | 620 | 48639 | 125022 | 29778197 |
Sputum discoloured | 253.54 | 10.81 | 150 | 49109 | 6518 | 29896701 |
Forced expiratory volume decreased | 243.38 | 10.81 | 115 | 49144 | 3135 | 29900084 |
Productive cough | 228.94 | 10.81 | 264 | 48995 | 29689 | 29873530 |
Blood count abnormal | 184.20 | 10.81 | 153 | 49106 | 11499 | 29891720 |
Eosinophilic granulomatosis with polyangiitis | 172.14 | 10.81 | 69 | 49190 | 1246 | 29901973 |
Toxicity to various agents | 157.43 | 10.81 | 48 | 49211 | 177135 | 29726084 |
Pneumonia | 155.61 | 10.81 | 1009 | 48250 | 333297 | 29569922 |
Pulmonary function test decreased | 131.10 | 10.81 | 84 | 49175 | 4211 | 29899008 |
Infective pulmonary exacerbation of cystic fibrosis | 128.13 | 10.81 | 109 | 49150 | 8463 | 29894756 |
Bronchiectasis | 114.19 | 10.81 | 83 | 49176 | 5121 | 29898098 |
Completed suicide | 110.64 | 10.81 | 16 | 49243 | 99476 | 29803743 |
Nasal congestion | 108.46 | 10.81 | 143 | 49116 | 18423 | 29884796 |
Chest discomfort | 107.95 | 10.81 | 234 | 49025 | 45246 | 29857973 |
Lower respiratory tract infection | 104.13 | 10.81 | 170 | 49089 | 26544 | 29876675 |
Therapeutic product effect incomplete | 102.88 | 10.81 | 193 | 49066 | 33641 | 29869578 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 101.27 | 10.81 | 39 | 49220 | 630 | 29902589 |
Nasal obstruction | 100.54 | 10.81 | 39 | 49220 | 643 | 29902576 |
Product quality issue | 95.15 | 10.81 | 135 | 49124 | 18639 | 29884580 |
Respiratory tract congestion | 86.38 | 10.81 | 72 | 49187 | 5434 | 29897785 |
Blood immunoglobulin E increased | 84.88 | 10.81 | 46 | 49213 | 1684 | 29901535 |
Bronchitis | 83.51 | 10.81 | 193 | 49066 | 38932 | 29864287 |
Respiratory disorder | 78.81 | 10.81 | 119 | 49140 | 17375 | 29885844 |
Sinus pain | 75.96 | 10.81 | 32 | 49227 | 659 | 29902560 |
Nasal polyps | 74.23 | 10.81 | 39 | 49220 | 1340 | 29901879 |
Emphysema | 73.67 | 10.81 | 84 | 49175 | 9318 | 29893901 |
Sinusitis | 70.62 | 10.81 | 164 | 49095 | 33181 | 29870038 |
Nasopharyngitis | 70.45 | 10.81 | 235 | 49024 | 58614 | 29844605 |
Breath sounds abnormal | 68.17 | 10.81 | 60 | 49199 | 4875 | 29898344 |
Middle insomnia | 63.86 | 10.81 | 62 | 49197 | 5711 | 29897508 |
Respiratory rate increased | 63.76 | 10.81 | 76 | 49183 | 8839 | 29894380 |
Dyspnoea exertional | 63.06 | 10.81 | 163 | 49096 | 35267 | 29867952 |
Drug abuse | 63.05 | 10.81 | 28 | 49231 | 82044 | 29821175 |
Painful respiration | 59.65 | 10.81 | 33 | 49226 | 1259 | 29901960 |
Hypoventilation | 59.12 | 10.81 | 45 | 49214 | 2978 | 29900241 |
Malaise | 58.68 | 10.81 | 472 | 48787 | 166490 | 29736729 |
Thrombocytopenia | 56.72 | 10.81 | 86 | 49173 | 136958 | 29766261 |
Febrile neutropenia | 55.65 | 10.81 | 56 | 49203 | 106637 | 29796582 |
Dust allergy | 54.99 | 10.81 | 22 | 49237 | 395 | 29902824 |
Sleep disorder due to a general medical condition | 54.92 | 10.81 | 33 | 49226 | 1474 | 29901745 |
Mycobacterium avium complex infection | 54.44 | 10.81 | 41 | 49218 | 2670 | 29900549 |
Status asthmaticus | 52.98 | 10.81 | 20 | 49239 | 305 | 29902914 |
Nasal disorder | 51.58 | 10.81 | 29 | 49230 | 1142 | 29902077 |
Sensitivity to weather change | 50.83 | 10.81 | 31 | 49228 | 1423 | 29901796 |
Pulmonary mass | 50.50 | 10.81 | 75 | 49184 | 10787 | 29892432 |
Heart rate increased | 50.26 | 10.81 | 159 | 49100 | 38562 | 29864657 |
Inhalation therapy | 50.25 | 10.81 | 12 | 49247 | 29 | 29903190 |
Pulmonary function test abnormal | 49.41 | 10.81 | 30 | 49229 | 1366 | 29901853 |
Throat irritation | 47.09 | 10.81 | 64 | 49195 | 8484 | 29894735 |
Influenza | 45.58 | 10.81 | 166 | 49093 | 43232 | 29859987 |
Body temperature decreased | 45.37 | 10.81 | 67 | 49192 | 9588 | 29893631 |
Osteopenia | 44.22 | 10.81 | 46 | 49213 | 4602 | 29898617 |
Respiratory tract infection | 42.87 | 10.81 | 85 | 49174 | 15421 | 29887798 |
Restrictive pulmonary disease | 42.83 | 10.81 | 25 | 49234 | 1058 | 29902161 |
Infective exacerbation of chronic obstructive airways disease | 40.78 | 10.81 | 27 | 49232 | 1431 | 29901788 |
Platelet count decreased | 40.69 | 10.81 | 70 | 49189 | 106059 | 29797160 |
Oxygen saturation decreased | 39.73 | 10.81 | 159 | 49100 | 43281 | 29859938 |
Off label use | 39.64 | 10.81 | 244 | 49015 | 249046 | 29654173 |
Asthmatic crisis | 39.26 | 10.81 | 18 | 49241 | 457 | 29902762 |
Foetal malformation | 38.62 | 10.81 | 13 | 49246 | 139 | 29903080 |
Renal impairment | 37.60 | 10.81 | 50 | 49209 | 84134 | 29819085 |
Eosinophil count increased | 36.77 | 10.81 | 53 | 49206 | 7420 | 29895799 |
Lower respiratory tract congestion | 36.44 | 10.81 | 22 | 49237 | 991 | 29902228 |
Walking aid user | 36.18 | 10.81 | 25 | 49234 | 1422 | 29901797 |
Increased viscosity of bronchial secretion | 36.13 | 10.81 | 14 | 49245 | 230 | 29902989 |
Blood pressure systolic increased | 34.96 | 10.81 | 77 | 49182 | 15033 | 29888186 |
Neutropenia | 34.46 | 10.81 | 103 | 49156 | 128437 | 29774782 |
Central obesity | 33.55 | 10.81 | 17 | 49242 | 541 | 29902678 |
Mite allergy | 33.20 | 10.81 | 13 | 49246 | 220 | 29902999 |
Bronchial hyperreactivity | 33.06 | 10.81 | 22 | 49237 | 1176 | 29902043 |
Chest injury | 32.78 | 10.81 | 23 | 49236 | 1341 | 29901878 |
Trisomy 18 | 32.67 | 10.81 | 13 | 49246 | 230 | 29902989 |
Granulomatous rosacea | 32.53 | 10.81 | 12 | 49247 | 171 | 29903048 |
Lung diffusion test decreased | 32.17 | 10.81 | 17 | 49242 | 591 | 29902628 |
Cystic fibrosis | 32.12 | 10.81 | 28 | 49231 | 2246 | 29900973 |
Adrenal suppression | 31.53 | 10.81 | 17 | 49242 | 616 | 29902603 |
Pancytopenia | 30.89 | 10.81 | 58 | 49201 | 84994 | 29818225 |
Blood pressure increased | 30.66 | 10.81 | 213 | 49046 | 71715 | 29831504 |
Rhabdomyolysis | 30.22 | 10.81 | 36 | 49223 | 63544 | 29839675 |
Oral candidiasis | 29.78 | 10.81 | 60 | 49199 | 11011 | 29892208 |
Nasal discharge discolouration | 29.52 | 10.81 | 12 | 49247 | 225 | 29902994 |
Lung hyperinflation | 29.40 | 10.81 | 18 | 49241 | 832 | 29902387 |
Intentional overdose | 29.04 | 10.81 | 16 | 49243 | 41465 | 29861754 |
Death | 28.93 | 10.81 | 414 | 48845 | 356869 | 29546350 |
Cerebral artery thrombosis | 28.80 | 10.81 | 15 | 49244 | 506 | 29902713 |
Sputum increased | 28.54 | 10.81 | 24 | 49235 | 1833 | 29901386 |
Diarrhoea | 28.52 | 10.81 | 383 | 48876 | 333720 | 29569499 |
Brain scan abnormal | 28.30 | 10.81 | 16 | 49243 | 637 | 29902582 |
Bronchial wall thickening | 27.84 | 10.81 | 14 | 49245 | 438 | 29902781 |
Reversible airways obstruction | 27.63 | 10.81 | 12 | 49247 | 267 | 29902952 |
Blood immunoglobulin E decreased | 27.13 | 10.81 | 8 | 49251 | 53 | 29903166 |
Rhinitis | 24.91 | 10.81 | 34 | 49225 | 4525 | 29898694 |
Sputum purulent | 24.89 | 10.81 | 13 | 49246 | 441 | 29902778 |
Bone marrow failure | 24.75 | 10.81 | 9 | 49250 | 29776 | 29873443 |
Stress | 24.36 | 10.81 | 81 | 49178 | 20154 | 29883065 |
Upper-airway cough syndrome | 24.32 | 10.81 | 26 | 49233 | 2684 | 29900535 |
Lung consolidation | 24.18 | 10.81 | 35 | 49224 | 4917 | 29898302 |
White blood cell count decreased | 24.15 | 10.81 | 65 | 49194 | 83882 | 29819337 |
Aspartate aminotransferase increased | 24.14 | 10.81 | 42 | 49217 | 63380 | 29839839 |
Hepatic failure | 24.02 | 10.81 | 13 | 49246 | 34030 | 29869189 |
Hepatic haematoma | 24.01 | 10.81 | 13 | 49246 | 475 | 29902744 |
Transposition of the great vessels | 23.91 | 10.81 | 13 | 49246 | 479 | 29902740 |
Rhonchi | 23.84 | 10.81 | 21 | 49238 | 1708 | 29901511 |
Respiratory tract irritation | 23.62 | 10.81 | 9 | 49250 | 141 | 29903078 |
Rales | 23.48 | 10.81 | 40 | 49219 | 6460 | 29896759 |
Alanine aminotransferase increased | 23.31 | 10.81 | 55 | 49204 | 74221 | 29828998 |
Forced vital capacity decreased | 23.31 | 10.81 | 15 | 49244 | 757 | 29902462 |
Multiple organ dysfunction syndrome | 23.30 | 10.81 | 43 | 49216 | 63444 | 29839775 |
Blood creatinine increased | 23.21 | 10.81 | 75 | 49184 | 91300 | 29811919 |
Growth retardation | 23.20 | 10.81 | 20 | 49239 | 1580 | 29901639 |
Bronchospasm | 23.15 | 10.81 | 52 | 49207 | 10286 | 29892933 |
Conjunctivitis allergic | 22.91 | 10.81 | 13 | 49246 | 521 | 29902698 |
Sputum abnormal | 22.84 | 10.81 | 12 | 49247 | 412 | 29902807 |
Dysphonia | 22.74 | 10.81 | 76 | 49183 | 18956 | 29884263 |
Malignant neoplasm progression | 22.31 | 10.81 | 54 | 49205 | 72233 | 29830986 |
Rhinorrhoea | 22.30 | 10.81 | 80 | 49179 | 20674 | 29882545 |
Mycotic allergy | 22.17 | 10.81 | 9 | 49250 | 168 | 29903051 |
Lung disorder | 21.78 | 10.81 | 106 | 49153 | 31363 | 29871856 |
Respiratory symptom | 20.86 | 10.81 | 14 | 49245 | 759 | 29902460 |
Blood pressure diastolic decreased | 20.76 | 10.81 | 37 | 49222 | 6194 | 29897025 |
Respiratory distress | 20.67 | 10.81 | 108 | 49151 | 32864 | 29870355 |
Drug resistance | 20.67 | 10.81 | 4 | 49255 | 20129 | 29883090 |
Anaemia | 20.50 | 10.81 | 231 | 49028 | 207761 | 29695458 |
Anosmia | 20.36 | 10.81 | 21 | 49238 | 2079 | 29901140 |
Sneezing | 20.29 | 10.81 | 30 | 49229 | 4297 | 29898922 |
Upper respiratory tract infection | 20.07 | 10.81 | 94 | 49165 | 27382 | 29875837 |
Necrotising oesophagitis | 20.04 | 10.81 | 11 | 49248 | 413 | 29902806 |
Hepatotoxicity | 19.96 | 10.81 | 3 | 49256 | 18142 | 29885077 |
Sepsis | 19.87 | 10.81 | 150 | 49109 | 146245 | 29756974 |
Lipohypertrophy | 19.80 | 10.81 | 10 | 49249 | 316 | 29902903 |
Product use in unapproved indication | 19.76 | 10.81 | 59 | 49200 | 73634 | 29829585 |
Nasal inflammation | 19.57 | 10.81 | 9 | 49250 | 230 | 29902989 |
Bone deformity | 19.37 | 10.81 | 6 | 49253 | 48 | 29903171 |
Eosinophilia | 19.36 | 10.81 | 80 | 49179 | 22080 | 29881139 |
Weight increased | 19.20 | 10.81 | 198 | 49061 | 74715 | 29828504 |
Cushingoid | 19.11 | 10.81 | 22 | 49237 | 2465 | 29900754 |
Renal failure | 19.02 | 10.81 | 129 | 49130 | 128837 | 29774382 |
Coma uraemic | 18.95 | 10.81 | 6 | 49253 | 52 | 29903167 |
Carcinoid tumour of the gastrointestinal tract | 18.95 | 10.81 | 6 | 49253 | 52 | 29903167 |
Aortic aneurysm | 18.75 | 10.81 | 36 | 49223 | 6377 | 29896842 |
Aspirin-exacerbated respiratory disease | 18.68 | 10.81 | 10 | 49249 | 357 | 29902862 |
Alveolar bone resorption | 18.31 | 10.81 | 5 | 49254 | 24 | 29903195 |
Throat tightness | 18.19 | 10.81 | 38 | 49221 | 7154 | 29896065 |
Seasonal allergy | 18.17 | 10.81 | 30 | 49229 | 4723 | 29898496 |
Atopy | 18.12 | 10.81 | 7 | 49252 | 114 | 29903105 |
Leukopenia | 18.09 | 10.81 | 41 | 49218 | 56118 | 29847101 |
Neuropathy peripheral | 17.78 | 10.81 | 58 | 49201 | 70417 | 29832802 |
Spirometry abnormal | 17.68 | 10.81 | 9 | 49250 | 289 | 29902930 |
Hypopnoea | 17.64 | 10.81 | 15 | 49244 | 1163 | 29902056 |
Forced expiratory flow decreased | 17.58 | 10.81 | 7 | 49252 | 124 | 29903095 |
Product complaint | 17.48 | 10.81 | 33 | 49226 | 5773 | 29897446 |
Ascites | 17.43 | 10.81 | 20 | 49239 | 35901 | 29867318 |
Blood test abnormal | 17.38 | 10.81 | 32 | 49227 | 5493 | 29897726 |
Malpositioned teeth | 17.24 | 10.81 | 5 | 49254 | 31 | 29903188 |
Neutrophil count decreased | 17.19 | 10.81 | 27 | 49232 | 42427 | 29860792 |
Sinus congestion | 16.98 | 10.81 | 29 | 49230 | 4693 | 29898526 |
Bronchopulmonary aspergillosis allergic | 16.92 | 10.81 | 9 | 49250 | 317 | 29902902 |
Eye infection | 16.76 | 10.81 | 22 | 49237 | 2820 | 29900399 |
Drug-induced liver injury | 16.73 | 10.81 | 7 | 49252 | 21267 | 29881952 |
Weight decreased | 16.58 | 10.81 | 344 | 48915 | 150577 | 29752642 |
Peak expiratory flow rate decreased | 16.58 | 10.81 | 7 | 49252 | 145 | 29903074 |
Bronchial disorder | 16.55 | 10.81 | 13 | 49246 | 901 | 29902318 |
Cortisol decreased | 16.50 | 10.81 | 13 | 49246 | 905 | 29902314 |
Extra dose administered | 16.49 | 10.81 | 22 | 49237 | 2864 | 29900355 |
Nausea | 16.38 | 10.81 | 368 | 48891 | 296589 | 29606630 |
Haemoptysis | 16.28 | 10.81 | 97 | 49162 | 30981 | 29872238 |
Hepatocellular injury | 16.19 | 10.81 | 11 | 49248 | 25460 | 29877759 |
Electrocardiogram QT shortened | 15.98 | 10.81 | 7 | 49252 | 159 | 29903060 |
Loss of personal independence in daily activities | 15.96 | 10.81 | 74 | 49185 | 21461 | 29881758 |
Polyp | 15.83 | 10.81 | 23 | 49236 | 3243 | 29899976 |
Crepitations | 15.69 | 10.81 | 22 | 49237 | 3002 | 29900217 |
Tubulointerstitial nephritis | 15.57 | 10.81 | 5 | 49254 | 17886 | 29885333 |
Cytomegalovirus infection | 15.35 | 10.81 | 10 | 49249 | 23664 | 29879555 |
Hot flush | 15.27 | 10.81 | 56 | 49203 | 14624 | 29888595 |
Flour sensitivity | 15.15 | 10.81 | 5 | 49254 | 50 | 29903169 |
Proteinuria | 14.99 | 10.81 | 4 | 49255 | 16141 | 29887078 |
Rhinitis perennial | 14.83 | 10.81 | 6 | 49253 | 111 | 29903108 |
Drug reaction with eosinophilia and systemic symptoms | 14.78 | 10.81 | 15 | 49244 | 28473 | 29874746 |
Mucosal inflammation | 14.77 | 10.81 | 17 | 49242 | 30477 | 29872742 |
Pneumocystis jirovecii pneumonia | 14.52 | 10.81 | 5 | 49254 | 17115 | 29886104 |
Food allergy | 14.50 | 10.81 | 12 | 49247 | 896 | 29902323 |
Acute respiratory failure | 14.40 | 10.81 | 82 | 49177 | 25768 | 29877451 |
Cholestasis | 14.29 | 10.81 | 12 | 49247 | 24938 | 29878281 |
Diffuse panbronchiolitis | 14.16 | 10.81 | 3 | 49256 | 3 | 29903216 |
Aphonia | 14.12 | 10.81 | 21 | 49238 | 3023 | 29900196 |
Chronic sinusitis | 14.06 | 10.81 | 15 | 49244 | 1544 | 29901675 |
Neoplasm progression | 14.06 | 10.81 | 6 | 49253 | 18017 | 29885202 |
Hepatic function abnormal | 14.02 | 10.81 | 30 | 49229 | 41915 | 29861304 |
Peritonitis | 13.90 | 10.81 | 9 | 49250 | 21366 | 29881853 |
Dehydration | 13.87 | 10.81 | 133 | 49126 | 123406 | 29779813 |
Infective exacerbation of bronchiectasis | 13.68 | 10.81 | 9 | 49250 | 472 | 29902747 |
Throat clearing | 13.52 | 10.81 | 7 | 49252 | 233 | 29902986 |
Rhinitis allergic | 13.47 | 10.81 | 20 | 49239 | 2874 | 29900345 |
Respiration abnormal | 13.38 | 10.81 | 19 | 49240 | 2623 | 29900596 |
Nightmare | 13.36 | 10.81 | 47 | 49212 | 12029 | 29891190 |
Spleen congestion | 13.10 | 10.81 | 8 | 49251 | 368 | 29902851 |
Hypersensitivity | 12.99 | 10.81 | 141 | 49118 | 53887 | 29849332 |
Increased upper airway secretion | 12.85 | 10.81 | 15 | 49244 | 1705 | 29901514 |
Plasma cell myeloma | 12.80 | 10.81 | 45 | 49214 | 53417 | 29849802 |
Neurotoxicity | 12.75 | 10.81 | 3 | 49256 | 13179 | 29890040 |
Disease progression | 12.73 | 10.81 | 78 | 49181 | 79796 | 29823423 |
Hyperbilirubinaemia | 12.65 | 10.81 | 6 | 49253 | 16936 | 29886283 |
Pseudomonas infection | 12.65 | 10.81 | 42 | 49217 | 10440 | 29892779 |
Acute myeloid leukaemia | 12.52 | 10.81 | 7 | 49252 | 17999 | 29885220 |
Cerebral infarction | 12.45 | 10.81 | 15 | 49244 | 26358 | 29876861 |
Drug intolerance | 12.33 | 10.81 | 36 | 49223 | 45255 | 29857964 |
Meralgia paraesthetica | 12.20 | 10.81 | 6 | 49253 | 179 | 29903040 |
Deformity thorax | 12.12 | 10.81 | 4 | 49255 | 40 | 29903179 |
Dyspnoea at rest | 12.12 | 10.81 | 18 | 49241 | 2588 | 29900631 |
Bronchitis bacterial | 12.12 | 10.81 | 10 | 49249 | 744 | 29902475 |
Alpha-1 antitrypsin deficiency | 12.09 | 10.81 | 3 | 49256 | 9 | 29903210 |
Somnambulism | 11.90 | 10.81 | 20 | 49239 | 3194 | 29900025 |
Hypovolaemic shock | 11.65 | 10.81 | 30 | 49229 | 6470 | 29896749 |
Acute respiratory distress syndrome | 11.46 | 10.81 | 13 | 49246 | 23459 | 29879760 |
Depressed level of consciousness | 11.44 | 10.81 | 29 | 49230 | 38193 | 29865026 |
Hypohidrosis | 11.42 | 10.81 | 6 | 49253 | 206 | 29903013 |
Intentional product misuse | 11.41 | 10.81 | 25 | 49234 | 34642 | 29868577 |
Eosinophilic bronchitis | 11.39 | 10.81 | 4 | 49255 | 49 | 29903170 |
Delirium | 11.27 | 10.81 | 32 | 49227 | 40599 | 29862620 |
Carcinoid tumour of the stomach | 11.25 | 10.81 | 4 | 49255 | 51 | 29903168 |
Eye disorder | 11.19 | 10.81 | 33 | 49226 | 7701 | 29895518 |
Vomiting | 11.10 | 10.81 | 276 | 48983 | 219542 | 29683677 |
Type 2 diabetes mellitus | 10.99 | 10.81 | 48 | 49211 | 13574 | 29889645 |
Hypokalaemic syndrome | 10.89 | 10.81 | 3 | 49256 | 15 | 29903204 |
Ileus | 10.89 | 10.81 | 6 | 49253 | 15549 | 29887670 |
Epidural lipomatosis | 10.82 | 10.81 | 6 | 49253 | 230 | 29902989 |
Source | Code | Description |
---|---|---|
ATC | R03AC12 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists |
ATC | R03AK06 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AK12 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
FDA MoA | N0000009922 | Adrenergic beta2-Agonists |
FDA EPC | N0000175779 | beta2-Adrenergic Agonist |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D000322 | Adrenergic Agonists |
MeSH PA | D058666 | Adrenergic beta-2 Receptor Agonists |
MeSH PA | D000318 | Adrenergic beta-Agonists |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D019141 | Respiratory System Agents |
CHEBI has role | CHEBI:35522 | beta-adrenergic receptor agonist |
CHEBI has role | CHEBI:35523 | bronchodilator agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pulmonary emphysema | indication | 87433001 | |
Non-allergic asthma | indication | 266361008 | DOID:9360 |
Allergic asthma | indication | 389145006 | DOID:9415 |
Adjunct Therapy to Achieve Long-term Asthma Control | indication | ||
Bronchospasm Prevention with COPD | indication | ||
Exercise-Induced Bronchospasm Prevention | indication | ||
COPD Associated with Chronic Bronchitis | indication | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Disease caused by parasite | contraindication | 17322007 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Acute tuberculosis | contraindication | 25629007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Ketoacidosis | contraindication | 56051008 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Candidiasis of mouth | contraindication | 79740000 | DOID:14262 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Bilateral cataracts | contraindication | 95722004 | |
Prolonged QT interval | contraindication | 111975006 | |
Seizure disorder | contraindication | 128613002 | |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Exacerbation of asthma | contraindication | 281239006 | |
Osteopenia | contraindication | 312894000 | |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Congenital long QT syndrome | contraindication | 442917000 | |
Uncontrolled Bacterial Infections | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.07 | acidic |
pKa2 | 9.28 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-2 adrenergic receptor | GPCR | AGONIST | Ki | 9.41 | CHEMBL | CHEMBL | |||
Aldehyde oxidase | Enzyme | IC50 | 5.00 | WOMBAT-PK | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 6.10 | CHEMBL | |||||
Beta-3 adrenergic receptor | GPCR | EC50 | 6 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 5.98 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | EC50 | 7.50 | CHEMBL |
ID | Source |
---|---|
4023955 | VUID |
N0000021960 | NUI |
D00687 | KEGG_DRUG |
94749-08-3 | SECONDARY_CAS_RN |
4020873 | VANDF |
4023955 | VANDF |
C0245531 | UMLSCUI |
CHEBI:9011 | CHEBI |
K5Y | PDB_CHEM_ID |
CHEMBL1263 | ChEMBL_ID |
CHEMBL1082607 | ChEMBL_ID |
D000068299 | MESH_DESCRIPTOR_UI |
559 | IUPHAR_LIGAND_ID |
5578 | INN_ID |
DB00938 | DRUGBANK_ID |
2I4BC502BT | UNII |
5152 | PUBCHEM_CID |
203159 | RXNORM |
1605 | MMSL |
21564 | MMSL |
5440 | MMSL |
d03759 | MMSL |
004036 | NDDF |
004037 | NDDF |
108605008 | SNOMEDCT_US |
108606009 | SNOMEDCT_US |
372515005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0326 | POWDER | 50 ug | RESPIRATORY (INHALATION) | ANDA | 29 sections |
fluticasone propionate and salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0327 | POWDER | 50 ug | RESPIRATORY (INHALATION) | ANDA | 29 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3607 | POWDER, METERED | 14 ug | RESPIRATORY (INHALATION) | NDA AUTHORIZED GENERIC | 28 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3608 | POWDER, METERED | 14 ug | RESPIRATORY (INHALATION) | NDA AUTHORIZED GENERIC | 28 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-3609 | POWDER, METERED | 14 ug | RESPIRATORY (INHALATION) | NDA AUTHORIZED GENERIC | 28 sections |
SEREVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0520 | POWDER, METERED | 50 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
SEREVENTDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0521 | POWDER, METERED | 50 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0695 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0696 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0697 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
ADVAIR HFA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0715 | AEROSOL, METERED | 21 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
ADVAIR HFA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0716 | AEROSOL, METERED | 21 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
ADVAIR HFA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0717 | AEROSOL, METERED | 21 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
Wixela Inhub | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-9320 | POWDER | 50 ug | RESPIRATORY (INHALATION) | ANDA | 30 sections |
Wixela Inhub | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-9321 | POWDER | 50 ug | RESPIRATORY (INHALATION) | ANDA | 30 sections |
Wixela Inhub | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-9322 | POWDER | 50 ug | RESPIRATORY (INHALATION) | ANDA | 30 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-196 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 30 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-197 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 30 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-361 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 30 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 33261-873 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 33261-874 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
ADVAIRDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-0731 | POWDER | 0.05 mg | RESPIRATORY (INHALATION) | NDA | 28 sections |
Fluticasone Propionate and Salmeterol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-3387 | POWDER, METERED | 14 ug | RESPIRATORY (INHALATION) | NDA AUTHORIZED GENERIC | 28 sections |
Fluticasone Propionate and SalmeterolDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-4211 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 29 sections |
Fluticasone Propionate and SalmeterolDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-4213 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 29 sections |
Fluticasone Propionate and SalmeterolDISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-4214 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 29 sections |
ADVAIR DISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-4516 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 30 sections |
ADVAIR DISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-4517 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 30 sections |
ADVAIR DISKUS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-4518 | POWDER | 50 ug | RESPIRATORY (INHALATION) | NDA | 30 sections |
AirDuo Digihaler | HUMAN PRESCRIPTION DRUG LABEL | 2 | 59310-111 | POWDER, METERED | 14 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |