bitolterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 384 30392-40-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bitolterol methanesulfonate
  • tornalate
  • bitolterol mesylate
  • bitolterol
  • bitolterol mesilate
a short-acting beta2 adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD
  • Molecular weight: 461.56
  • Formula: C28H31NO5
  • CLOGP: 5.77
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 2
  • TPSA: 84.86
  • ALOGS: -5.98
  • ROTB: 10

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 28, 1984 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AC17 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35522 beta-adrenergic agonists
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchiectasis indication 12295008 DOID:9563
Bronchitis indication 32398004 DOID:6132
Pulmonary emphysema indication 87433001
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Acute exacerbation of asthma indication 708038006
Bronchospasm Prevention indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 14.0 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST CHEMBL CHEMBL

External reference:

IDSource
4019101 VUID
N0000147359 NUI
D00684 KEGG_DRUG
30392-41-7 SECONDARY_CAS_RN
19499 RXNORM
C0053817 UMLSCUI
CHEBI:3133 CHEBI
CHEMBL1201295 ChEMBL_ID
CHEMBL1200405 ChEMBL_ID
DB00901 DRUGBANK_ID
C011685 MESH_SUPPLEMENTAL_RECORD_UI
3855 INN_ID
9KY0QXD6LI UNII
35330 PUBCHEM_CID
1209 MMSL
4292 MMSL
d00754 MMSL
387233000 SNOMEDCT_US
412217002 SNOMEDCT_US
41985001 SNOMEDCT_US
4019101 VANDF
4019636 VANDF
001816 NDDF
004733 NDDF

Pharmaceutical products:

None