dexpanthenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
838 81-13-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexpanthenol
  • (+)-panthenol
  • bepanthen
  • D-Panthenol
The alcohol of pantothenic acid
  • Molecular weight: 205.25
  • Formula: C9H19NO4
  • CLOGP: -1.65
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 89.79
  • ALOGS: -0.23
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,MAP2K6,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1 36
kinase-selectivity-class ACVRL1,AXL,BRAF,CDK1,CDK2,CDK4,CDK6,CDK9,CHUK,DYRK1A,EPHB4,GRK2,MAP2K6,MAP3K21,PDK1,PDK2,TEK,TGFBR1 18
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 156.61 14.09 84 11220 40856 90576287
Gastrooesophageal reflux disease 115.34 14.09 122 11182 166215 90450928
Coma 101.36 14.09 79 11225 72553 90544590
Toxic epidermal necrolysis 84.80 14.09 52 11252 32476 90584667
Female genital tract fistula 80.69 14.09 41 11263 17827 90599316
Chronic sinusitis 74.98 14.09 43 11261 23759 90593384
Epidermal necrosis 73.21 14.09 22 11282 2339 90614804
Vaginal flatulence 68.99 14.09 33 11271 12605 90604538
Proctitis 63.09 14.09 33 11271 15226 90601917
Radiculopathy 59.81 14.09 34 11270 18471 90598672
Vaginal discharge 55.58 14.09 33 11271 19431 90597712
Epilepsy 51.13 14.09 57 11247 82149 90534994
Paraesthesia oral 49.79 14.09 37 11267 31622 90585521
Somnolence 46.50 14.09 89 11215 208995 90408148
Oral candidiasis 46.07 14.09 37 11267 35418 90581725
Facet joint syndrome 44.45 14.09 58 11246 98331 90518812
Colitis 44.36 14.09 49 11255 69893 90547250
Procedural pain 43.74 14.09 35 11269 33325 90583818
Macular degeneration 41.80 14.09 36 11268 37934 90579209
Lip dry 37.29 14.09 54 11250 100901 90516242
Osteoarthritis 37.14 14.09 78 11226 195652 90421491
Bursitis 36.88 14.09 62 11242 131592 90485551
Nail disorder 36.79 14.09 41 11263 59026 90558117
Tumour pain 35.42 14.09 12 11292 1875 90615268
Rash papular 34.74 14.09 25 11279 20330 90596813
Frequent bowel movements 34.57 14.09 39 11265 56896 90560247
Colitis ulcerative 32.77 14.09 39 11265 60227 90556916
Obesity 32.68 14.09 52 11252 105455 90511688
Wound infection 32.35 14.09 52 11252 106350 90510793
Pulmonary vein occlusion 31.31 14.09 6 11298 90 90617053
Breast cancer stage III 30.93 14.09 45 11259 84402 90532741
Plasma cells increased 30.55 14.09 6 11298 103 90617040
Underdose 29.44 14.09 35 11269 53982 90563161
Intestinal haemorrhage 28.57 14.09 13 11291 4434 90612709
Live birth 24.51 14.09 39 11265 79068 90538075
Rectal haemorrhage 23.20 14.09 39 11265 82705 90534438
Inflammation 22.79 14.09 61 11243 178531 90438612
Haematochezia 22.02 14.09 35 11269 70878 90546265
Drug interaction 21.91 14.09 4 11300 276449 90340694
C-reactive protein 21.67 14.09 23 11281 31344 90585799
Musculoskeletal pain 21.36 14.09 58 11246 171193 90445950
Anterior segment ischaemia 21.34 14.09 4 11300 53 90617090
Toxicity to various agents 21.09 14.09 5 11299 287841 90329302
Optic nerve disorder 19.75 14.09 7 11297 1251 90615892
Stomatitis 19.69 14.09 77 11227 274621 90342522
Peripheral venous disease 18.97 14.09 36 11268 83885 90533258
Wheezing 18.94 14.09 69 11235 238011 90379132
Liver injury 18.57 14.09 55 11249 170512 90446631
Death 18.28 14.09 18 11286 456533 90160610
Stevens-Johnson syndrome 17.62 14.09 20 11284 29356 90587787
Muscle injury 17.39 14.09 55 11249 176599 90440544
Psoriatic arthropathy 17.18 14.09 65 11239 228270 90388873
Sinusitis fungal 16.72 14.09 7 11297 1957 90615186
Blepharospasm 16.71 14.09 27 11277 55418 90561725
Drug ineffective 16.67 14.09 103 11201 1384195 89232948
Product dose omission issue 16.30 14.09 8 11296 291679 90325464
Taste disorder 15.93 14.09 28 11276 61518 90555625
Fibromyalgia 15.75 14.09 59 11245 206210 90410933
Streptococcal infection 14.84 14.09 10 11294 7323 90609820
Dyspepsia 14.56 14.09 56 11248 198104 90419039

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 48.15 21.06 61 3489 151185 42466600
Foetal malformation 47.98 21.06 9 3541 184 42617601
Appendicolith 41.72 21.06 21 3529 13435 42604350
Hyperphosphataemia 39.45 21.06 20 3530 12984 42604801
Dehiscence 37.14 21.06 9 3541 637 42617148
Febrile bone marrow aplasia 34.85 21.06 17 3533 10164 42607621
Trisomy 18 34.53 21.06 9 3541 856 42616929
Appendicitis 33.35 21.06 21 3529 20592 42597193
Myasthenia gravis 32.71 21.06 19 3531 16118 42601667
Analgesic therapy 32.06 21.06 14 3536 6510 42611275
Blood phosphorus increased 31.52 21.06 17 3533 12508 42605277
Swelling 31.10 21.06 30 3520 54855 42562930
Generalised oedema 30.94 21.06 18 3532 15318 42602467
Dry mouth 30.89 21.06 26 3524 39853 42577932
Face oedema 30.14 21.06 17 3533 13649 42604136
Drug therapy 29.12 21.06 13 3537 6367 42611418
Ventricular fibrillation 28.33 21.06 22 3528 30101 42587684
Hypophosphataemia 28.16 21.06 19 3531 20926 42596859
Sleep disorder therapy 28.15 21.06 13 3537 6881 42610904
Anaemia 27.26 21.06 67 3483 280211 42337574
Incorrect route of product administration 25.61 21.06 19 3531 24286 42593499
Blood uric acid increased 25.55 21.06 16 3534 15531 42602254
Iron deficiency 25.04 21.06 14 3536 11047 42606738
Neuralgia 24.70 21.06 19 3531 25628 42592157
Pulmonary embolism 24.31 21.06 39 3511 119573 42498212
Ascites 23.14 21.06 26 3524 56652 42561133
Cardiogenic shock 23.10 21.06 21 3529 35619 42582166
Bacteroides infection 21.14 21.06 8 3542 2579 42615206

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Female genital tract fistula 81.73 15.28 41 14482 16478 110558298
Gastrooesophageal reflux disease 81.51 15.28 109 14414 179867 110394909
Chronic sinusitis 70.82 15.28 43 14480 25041 110549735
Vaginal flatulence 68.61 15.28 33 14490 12111 110562665
Pneumonia aspiration 66.89 15.28 67 14456 81166 110493610
Epidermal necrosis 66.55 15.28 22 14501 3028 110571748
Toxic epidermal necrolysis 66.52 15.28 57 14466 56670 110518106
Proctitis 60.99 15.28 34 14489 16893 110557883
Radiculopathy 59.40 15.28 35 14488 19301 110555475
Macular degeneration 58.26 15.28 36 14487 21623 110553153
Vaginal discharge 56.55 15.28 33 14490 17875 110556901
Facet joint syndrome 50.62 15.28 63 14460 96765 110478011
Epilepsy 50.48 15.28 64 14459 100145 110474631
Osteoarthritis 46.66 15.28 85 14438 182538 110392238
Paraesthesia oral 46.06 15.28 37 14486 33634 110541142
Lip dry 42.81 15.28 59 14464 100024 110474752
Bursitis 41.80 15.28 67 14456 129851 110444925
Procedural pain 40.20 15.28 35 14488 35530 110539246
Nail disorder 39.13 15.28 43 14480 57892 110516884
Oral candidiasis 38.84 15.28 38 14485 44722 110530054
Wound infection 38.48 15.28 55 14468 96410 110478366
Coma 38.21 15.28 61 14462 117808 110456968
Toxicity to various agents 36.68 15.28 9 14514 480546 110094230
Breast cancer stage III 35.90 15.28 48 14475 79069 110495707
Obesity 35.83 15.28 58 14465 113293 110461483
Somnolence 34.14 15.28 101 14422 297348 110277428
Appendicolith 34.10 15.28 22 14501 14233 110560543
Tumour pain 32.99 15.28 13 14510 2954 110571822
Incorrect route of product administration 32.39 15.28 41 14482 64020 110510756
Colitis 31.86 15.28 52 14471 102271 110472505
Muscle injury 31.57 15.28 62 14461 140745 110434031
Live birth 31.28 15.28 42 14481 69442 110505334
Stomatitis 30.28 15.28 91 14432 270151 110304625
Plasma cells increased 29.19 15.28 6 14517 124 110574652
Hyperphosphataemia 29.01 15.28 21 14502 16360 110558416
Pulmonary vein occlusion 28.92 15.28 6 14517 130 110574646
Psoriatic arthropathy 27.70 15.28 72 14451 196689 110378087
Analgesic therapy 27.25 15.28 15 14508 7269 110567507
Dehiscence 27.20 15.28 8 14515 750 110574026
Liver injury 26.47 15.28 60 14463 150353 110424423
Frequent bowel movements 26 15.28 39 14484 71351 110503425
Fibromyalgia 25.57 15.28 64 14459 170845 110403931
Inflammation 25.46 15.28 69 14454 193169 110381607
Swelling 25.21 15.28 102 14421 350939 110223837
Duodenal ulcer perforation 24.98 15.28 65 14458 177635 110397141
Rash papular 24.98 15.28 24 14499 27615 110547161
Drug therapy 24.52 15.28 14 14509 7277 110567499
Sleep disorder therapy 24.20 15.28 14 14509 7457 110567319
Musculoskeletal pain 23.76 15.28 65 14458 182958 110391818
Lower respiratory tract infection 23.68 15.28 78 14445 243028 110331748
Underdose 23.55 15.28 35 14488 63519 110511257
General physical health deterioration 23.31 15.28 114 14409 425181 110149595
C-reactive protein 23.10 15.28 24 14499 30307 110544469
Anaemia 22.78 15.28 136 14387 546950 110027826
Blood phosphorus increased 22.44 15.28 18 14505 16322 110558454
Colitis ulcerative 22.32 15.28 38 14485 77325 110497451
Myasthenia gravis 21.98 15.28 20 14503 21491 110553285
Intestinal haemorrhage 21.79 15.28 13 14510 7328 110567448
Blood cholesterol increased 21.42 15.28 63 14460 184722 110390054
Dry mouth 21.14 15.28 66 14457 199882 110374894
Anterior segment ischaemia 21.13 15.28 4 14519 53 110574723
Drug ineffective 20.92 15.28 116 14407 1520424 109054352
Drug interaction 20.81 15.28 21 14502 500162 110074614
Appendicitis 20.74 15.28 22 14501 28442 110546334
Peripheral venous disease 20.02 15.28 38 14485 84079 110490697
Wheezing 19.80 15.28 76 14447 255154 110319622
Pericarditis 18.45 15.28 67 14456 219047 110355729
Hypophosphataemia 17.99 15.28 22 14501 33160 110541616
Stevens-Johnson syndrome 17.62 15.28 26 14497 46875 110527901
Dyspepsia 17.46 15.28 60 14463 190905 110383871
Optic nerve disorder 17.33 15.28 7 14516 1696 110573080
Abdominal pain 17.33 15.28 121 14402 512868 110061908
Breast cancer metastatic 16.82 15.28 13 14510 11168 110563608
Pemphigus 16.72 15.28 64 14459 214506 110360270
Bacteroides infection 16.69 15.28 8 14515 2911 110571865
Helicobacter infection 16.50 15.28 57 14466 181820 110392956
Product dose omission issue 16.49 15.28 11 14512 321771 110253005
Blood uric acid increased 16.33 15.28 17 14506 21512 110553264
Rectal haemorrhage 15.99 15.28 43 14480 119790 110454986
Blepharospasm 15.89 15.28 27 14496 54824 110519952
Ventricular fibrillation 15.66 15.28 23 14500 41290 110533486

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA30 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC D03AX03 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
ATC S01XA12 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
CHEBI has role CHEBI:38323 cholinergic drugs
CHEBI has role CHEBI:50188 provitamins

Related Drugs by ATC class:

A11HA Other plain vitamin preparations 10 drugs
D03AX Other cicatrizants 9 drugs
S01XA Other ophthalmologicals 24 drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Eczema indication 43116000
Toxicodendron radicans indication 52352005
Paralytic ileus indication 55525008 DOID:8442
Diaper rash indication 91487003
Disorder of skin indication 95320005 DOID:37
Contact dermatitis due to poison oak indication 200824008
Gastroparesis indication 235675006
Arthropod bite wound indication 409985002
Paralytic Ileus Prevention indication
Chafing of skin off-label use 238474002
Eruption of skin off-label use 271807003 DOID:0050486
Skin irritation off-label use 367466007
Itching of skin off-label use 418363000
Hemophilia contraindication 90935002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

None

External reference:

IDSource
4020828 VUID
N0000146036 NUI
22701 RXNORM
4017657 VANDF
4020828 VANDF
C0057610 UMLSCUI
CHEBI:27373 CHEBI
CHEMBL1200979 ChEMBL_ID
DB09357 DRUGBANK_ID
131204 PUBCHEM_CID
C007288 MESH_SUPPLEMENTAL_RECORD_UI
1023 INN_ID
1O6C93RI7Z UNII
1536 MMSL
4558 MMSL
d01001 MMSL
001696 NDDF
126226000 SNOMEDCT_US
404842009 SNOMEDCT_US
1O6C93RI7Z INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MIRACLE STEMCELL ALL-IN-ONE HUMAN OTC DRUG LABEL 2 24765-001 SHAMPOO 0.20 g TOPICAL unapproved drug other 7 sections
HASOL Anagen Hair Tonic HUMAN OTC DRUG LABEL 3 51270-122 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Anagen Scalp HUMAN OTC DRUG LABEL 3 51270-123 SHAMPOO 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Anti Hair Loss HUMAN OTC DRUG LABEL 3 51270-124 SHAMPOO 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Vital For Hair-Loss Tonic HUMAN OTC DRUG LABEL 3 51270-125 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9007 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9015 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9023 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9023 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 67457-146 INJECTION 2 mg INTRAVENOUS Unapproved drug other 9 sections
NDM SCALP HUMAN OTC DRUG LABEL 4 69288-001 SHAMPOO 1.40 g TOPICAL unapproved drug other 11 sections
YOZUM WELL BEING HAIR COLOR HUMAN OTC DRUG LABEL 1 69525-2001 LIQUID 0.20 g TOPICAL OTC monograph not final 7 sections
Notamo Hair Tonic HUMAN OTC DRUG LABEL 2 69709-102 LIQUID 0.20 1 TOPICAL unapproved drug other 8 sections
B-Combo HUMAN PRESCRIPTION DRUG LABEL 6 70104-110 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Therapytion Hair Tonic HUMAN OTC DRUG LABEL 2 70477-101 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
BABYSONS HUMAN OTC DRUG LABEL 1 73519-001 OINTMENT 50 mg TOPICAL unapproved drug other 11 sections
Yakkongmo scalp deep cleansingshampoo HUMAN OTC DRUG LABEL 4 73540-001 SHAMPOO 0.50 g TOPICAL unapproved drug other 7 sections
Yakkongmo hair serum tonic HUMAN OTC DRUG LABEL 3 73540-002 LIQUID 0.20 g TOPICAL unapproved drug other 7 sections
Yakkongmo treatment HUMAN OTC DRUG LABEL 3 73540-003 LIQUID 0.50 g TOPICAL unapproved drug other 7 sections
CRAZYSKIN BEERS HUMAN OTC DRUG LABEL 3 73643-0001 SHAMPOO 0.20 g TOPICAL unapproved drug other 7 sections
CRAZYSKIN BEERS PREMIUM HUMAN OTC DRUG LABEL 3 73643-0002 SHAMPOO 0.20 g TOPICAL unapproved drug other 7 sections
W.SKIN ANTI HAIR LOSS HUMAN OTC DRUG LABEL 3 74997-0016 SHAMPOO 0.50 g TOPICAL unapproved drug other 7 sections
The Fact Hair Care Scalp Booster Ampoule HUMAN OTC DRUG LABEL 3 77049-0013 LIQUID 0.20 g TOPICAL unapproved drug other 7 sections
BLACK REPAIR HAIR BOOSTING TONIC HUMAN OTC DRUG LABEL 3 79593-0005 LIQUID 0.20 g TOPICAL unapproved drug other 7 sections
Derma Hand Repair HUMAN OTC DRUG LABEL 2 82160-450 CREAM 22.50 mg TOPICAL unapproved drug other 13 sections
Derma Charcoal Mask HUMAN OTC DRUG LABEL 3 82160-672 GEL 15 mg TOPICAL unapproved drug other 17 sections
CH6 Perfumed Aloforthya Peony and the sunset HUMAN OTC DRUG LABEL 3 82916-050 SHAMPOO 0.20 g TOPICAL unapproved drug other 10 sections
MONPURIEL Daily all in one ample HUMAN OTC DRUG LABEL 3 83472-311 LIQUID 0.22 g TOPICAL unapproved drug other 11 sections
MONPURIEL Hair loss care-shampoo HUMAN OTC DRUG LABEL 3 83472-411 SHAMPOO 0.22 g TOPICAL unapproved drug other 11 sections