beremagene geperpavec 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5855 2241888-62-8

Description:

MoleculeDescription

Molfile

Synonyms:

  • beremagene geperpavec
  • KB103
  • vyjuvek
Beremagene geperpavec is a gene therapy based on an engineered, replication-defective herpes simplex virus 1 (HSV-1) encoded with COL7A1 gene, addressing the underlying genetic cause of dystrophic epidermolysis bullosa. The HSV-1 vector belongs to the human herpes virus (HHV) family of double-stranded DNA viruses. Upon cutaneous application to the wounds, beremagene geperpavec can transduce both keratinocytes and fibroblasts. Following entry of beremagene geperpavec into the cells, the vector genome is deposited in the nucleus without integrating into, or otherwise disrupting, host cell DNA. Once in the nucleus, transcription of the encoded human COL7A1 is initiated. The resulting transcripts allow for production and secretion of COL7 by the cell in its mature form. These COL7 molecules arrange themselves into long, thin bundles that form anchoring fibrils. The anchoring fibrils hold the epidermis and dermis together and are essential for maintaining the integrity of the skin.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
April 23, 2025 EMA Krystal Biotech Netherlands B.V.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D03AX16 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:73336 vulnerary

Related Drugs by ATC class:

D03AX Other cicatrizants 9 drugs
becaplermincalcium pantothenatecrilanomerdexpanthenolenoxolonehyaluronic acidsodium chloritetrafermintrolamine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dystrophic epidermolysis bullosa indication 61003004 DOID:2730




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Collagen alpha-1(VII) chain Adhesion OTHER UNKNOWN DRUG LABEL

External reference:

IDSource
CHEMBL4594328 ChEMBL_ID
C000731813 MESH_SUPPLEMENTAL_RECORD_UI
4042305 VANDF
C5420879 UMLSCUI
CHEBI:757826 CHEBI
11345 INN_ID
AQN7K24KQU UNII
2637758 RXNORM
D12632 KEGG_DRUG
370288 MMSL
41894 MMSL

Pharmaceutical products:

None