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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4348	299-28-5

Description:

Molecule	Description
Synonyms: calcium gluconate calciofon Calcium D-gluconate calcium gluconate monohydrate	The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states. Molecular weight: 430.37 Formula: C12H22CaO14 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 141.28 ALOGS: ROTB: None

Molecule

Description

Synonyms:

calcium gluconate
calciofon
Calcium D-gluconate
calcium gluconate monohydrate

The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.

Molecular weight: 430.37
Formula: C12H22CaO14
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 141.28
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
3	g	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Liver injury	621.24	16.51	817	91860	169750	90366020
Psoriatic arthropathy	557.01	16.51	905	91772	227430	90308340
Rheumatoid arthritis	371.04	16.51	1006	91671	361608	90174162
Pemphigus	351.68	16.51	924	91753	325940	90209830
Rheumatoid factor positive	323.90	16.51	608	92069	171042	90364728
Glossodynia	299.70	16.51	863	91814	320916	90214854
Swollen joint count increased	294.42	16.51	458	92219	110748	90425022
Systemic lupus erythematosus	280.42	16.51	910	91767	360986	90174784
Arthropathy	276.66	16.51	913	91764	365329	90170441
Rheumatic fever	260.22	16.51	519	92158	152602	90383168
Fall	257.48	16.51	86	92591	481724	90054046
Prescribed overdose	239.00	16.51	388	92289	97237	90438533
Pulmonary fibrosis	233.53	16.51	405	92272	107098	90428672
Fibromyalgia	228.58	16.51	590	92087	205679	90330091
Anti-cyclic citrullinated peptide antibody positive	225.65	16.51	640	92037	235793	90299977
Hand deformity	219.35	16.51	734	91943	295628	90240142
Product dose omission issue	219.34	16.51	22	92655	291665	90244105
Oedema	203.72	16.51	555	92122	199740	90336030
Type 2 diabetes mellitus	199.60	16.51	556	92121	202688	90333082
Dislocation of vertebra	194.02	16.51	262	92415	55706	90480064
Pericarditis	191.85	16.51	660	92017	269491	90266279
Adjustment disorder with depressed mood	186.66	16.51	259	92418	56494	90479276
Blood cholesterol increased	176.37	16.51	540	92137	207472	90328298
Lower limb fracture	175.18	16.51	313	92364	84700	90451070
Mobility decreased	171.44	16.51	605	92072	250129	90285641
Wound	165.10	16.51	680	91997	302300	90233470
Product use issue	163.97	16.51	720	91957	329199	90206571
Discomfort	158.45	16.51	627	92050	273708	90262062
Helicobacter infection	158.20	16.51	551	92126	226299	90309471
Lupus vulgaris	157.79	16.51	212	92465	44847	90490923
Duodenal ulcer perforation	155.62	16.51	539	92138	220749	90315021
Joint destruction	155.05	16.51	120	92557	13167	90522603
Alopecia	154.64	16.51	949	91728	494122	90041648
Injury	152.31	16.51	496	92181	196853	90338917
Wound infection	150.81	16.51	335	92342	106067	90429703
Death	150.55	16.51	147	92530	456404	90079366
Muscle injury	147.29	16.51	456	92221	176198	90359572
X-ray abnormal	145.93	16.51	205	92472	45219	90490551
Amnesia	143.09	16.51	332	92345	108173	90427597
Abdominal discomfort	139.69	16.51	900	91777	476428	90059342
Contraindicated product administered	139.29	16.51	672	92005	319467	90216303
Prescribed underdose	137.93	16.51	263	92414	74756	90461014
Synovitis	137.63	16.51	684	91993	329068	90206702
Deep vein thrombosis postoperative	132.36	16.51	250	92427	70559	90465211
Breast cancer stage II	127.94	16.51	169	92508	35165	90500605
Subcutaneous drug absorption impaired	127.71	16.51	108	92569	13437	90522333
Drug interaction	126.90	16.51	62	92615	276391	90259379
Joint range of motion decreased	124.23	16.51	362	92315	135281	90400489
Cough	122.51	16.51	118	92559	368844	90166926
Gait inability	117.40	16.51	373	92304	146083	90389687
Autoimmune disorder	117.14	16.51	249	92428	76495	90459275
Toxicity to various agents	117.07	16.51	75	92602	287771	90247999
Injection site pain	116.29	16.51	19	92658	173680	90362090
Wheezing	116.21	16.51	517	92160	237563	90298207
Irritable bowel syndrome	114.00	16.51	467	92210	206981	90328789
Drug tolerance	112.78	16.51	114	92563	17802	90517968
Intentional product use issue	111.19	16.51	478	92199	216414	90319356
Back pain	109.33	16.51	98	92579	317077	90218693
Hip arthroplasty	108.03	16.51	240	92437	75968	90459802
General symptom	106.66	16.51	101	92576	14567	90521203
Sleep disorder due to general medical condition, insomnia type	105.19	16.51	330	92347	128364	90407406
Rash vesicular	104.11	16.51	110	92567	18087	90517683
COVID-19	101.42	16.51	24	92653	168819	90366951
Urinary tract infection	101.13	16.51	98	92579	305534	90230236
Maternal exposure during pregnancy	100.39	16.51	671	92006	359392	90176378
Road traffic accident	100.24	16.51	289	92388	107337	90428433
Pustular psoriasis	98.83	16.51	108	92569	18448	90517322
Lip dry	98.81	16.51	276	92401	100679	90435091
Grip strength decreased	97.49	16.51	260	92417	92316	90443454
Sciatica	97.10	16.51	275	92402	101107	90434663
Delirium	96.97	16.51	280	92397	104079	90431691
Ulcer haemorrhage	95.46	16.51	126	92551	26195	90509575
Blister	95.24	16.51	513	92164	254485	90281285
Knee arthroplasty	95.17	16.51	241	92436	82941	90452829
Hypercholesterolaemia	95.00	16.51	272	92405	100620	90435150
Peripheral venous disease	94.83	16.51	242	92435	83679	90452091
Hypoaesthesia	94.57	16.51	597	92080	313613	90222157
Neutropenia	90.88	16.51	59	92618	224845	90310925
Disease progression	90.70	16.51	24	92653	156591	90379179
Swelling	90.58	16.51	735	91942	418323	90117447
Obesity	90.34	16.51	275	92402	105232	90430538
Back disorder	88.82	16.51	120	92557	25511	90510259
Influenza	87.27	16.51	18	92659	139246	90396524
Stomatitis	87.08	16.51	529	92148	274169	90261601
Somnolence	87.03	16.51	53	92624	209031	90326739
Polyarthritis	84.45	16.51	99	92578	18251	90517519
Acute kidney injury	84.35	16.51	123	92554	320264	90215506
Folliculitis	81	16.51	418	92259	203935	90331835
Therapy non-responder	79.25	16.51	313	92364	136391	90399379
Dyspnoea	77.20	16.51	556	92121	880399	89655371
Myositis	76.16	16.51	108	92569	24020	90511750
Tremor	75.50	16.51	31	92646	153142	90382628
Disability	73.83	16.51	142	92535	40603	90495167
Hypocalcaemia	73.54	16.51	145	92532	42223	90493547
Incorrect route of product administration	73.50	16.51	161	92516	50465	90485305
Musculoskeletal stiffness	71.71	16.51	534	92143	295998	90239772
Walking aid user	70.90	16.51	129	92548	35377	90500393
Myalgia	69.31	16.51	47	92630	175078	90360692
Sleep disorder	68.95	16.51	391	92286	197639	90338131
Feeling abnormal	68.74	16.51	43	92634	167192	90368578
Malignant neoplasm progression	68.66	16.51	13	92664	106857	90428913
Liver disorder	68.15	16.51	275	92402	120994	90414776
Ill-defined disorder	66.99	16.51	369	92308	184522	90351248
Lower respiratory tract infection	65.55	16.51	460	92217	250199	90285571
Nausea	65.54	16.51	774	91903	1109542	89426228
Inappropriate schedule of product administration	65.23	16.51	36	92641	149897	90385873
Blepharospasm	64.83	16.51	162	92515	55283	90480487
Foot deformity	64.28	16.51	169	92508	59482	90476288
Breast cancer stage III	63.94	16.51	211	92466	84236	90451534
Syncope	63.54	16.51	28	92649	132635	90403135
Balance disorder	61.96	16.51	12	92665	97068	90438702
Eye injury	61.95	16.51	66	92611	10954	90524816
Facet joint syndrome	61.70	16.51	231	92446	98158	90437612
Retinitis	61.25	16.51	127	92550	38331	90497439
Wrong technique in product usage process	60.63	16.51	3	92674	71568	90464202
Vision blurred	59.99	16.51	19	92658	110274	90425496
Memory impairment	59.42	16.51	375	92302	196869	90338901
Oropharyngeal pain	58.93	16.51	22	92655	115165	90420605
Rhinorrhoea	58.34	16.51	10	92667	88306	90447464
Productive cough	57.38	16.51	6	92671	77057	90458713
Adrenal insufficiency	56.34	16.51	106	92571	29815	90505955
Nasal congestion	56.09	16.51	9	92668	83405	90452365
Dry skin	55.97	16.51	11	92666	88062	90447708
Anti-cyclic citrullinated peptide antibody	55.75	16.51	100	92577	27121	90508649
Taste disorder	55.10	16.51	163	92514	61383	90474387
Constipation	54.83	16.51	129	92548	280266	90255504
Cerebrovascular accident	54.70	16.51	29	92648	123504	90412266
Impaired healing	54.47	16.51	418	92259	233781	90301989
Migraine	54.29	16.51	357	92320	190035	90345735
Dyspepsia	53.76	16.51	367	92310	197793	90337977
Infusion related reaction	53.39	16.51	656	92021	416124	90119646
Neuropathy peripheral	52.55	16.51	38	92639	136932	90398838
Dehydration	51.78	16.51	74	92603	194373	90341397
Influenza like illness	51.37	16.51	10	92667	80601	90455169
Myocardial infarction	51.33	16.51	22	92655	105950	90429820
Epistaxis	51.30	16.51	12	92665	85113	90450657
Haemoglobin decreased	51.17	16.51	54	92623	161902	90373868
Hyperhidrosis	50.77	16.51	39	92638	136266	90399504
Bone erosion	49.94	16.51	143	92534	52878	90482892
General physical health deterioration	49.90	16.51	569	92108	354546	90181224
Drug tolerance decreased	49.88	16.51	105	92572	32025	90503745
Dysphagia	48.78	16.51	27	92650	112251	90423519
Chest discomfort	48.53	16.51	42	92635	138323	90397447
Live birth	48.16	16.51	184	92493	78923	90456847
C-reactive protein	48.10	16.51	102	92575	31265	90504505
Hypertension	47.78	16.51	694	91983	456838	90078932
Erythema	47.64	16.51	102	92575	229144	90306626
Therapeutic product effect decreased	47.07	16.51	462	92215	277109	90258661
Pancytopenia	46.61	16.51	33	92644	120230	90415540
Hepatic enzyme increased	46.27	16.51	568	92109	360168	90175602
Stress	46.12	16.51	13	92664	81382	90454388
Immunodeficiency	46.08	16.51	122	92555	43112	90492658
Urticaria	45.70	16.51	505	92172	312229	90223541
Interstitial lung disease	45.59	16.51	11	92666	76394	90459376
Cardiac failure	45.20	16.51	28	92649	109468	90426302
Contusion	45.00	16.51	423	92254	250793	90284977
Injection site reaction	44.78	16.51	19	92658	92061	90443709
Porphyria acute	44.70	16.51	72	92605	17903	90517867
Swelling face	44.27	16.51	14	92663	81338	90454432
Injection site swelling	43.69	16.51	5	92672	59834	90475936
Abortion spontaneous	43.55	16.51	3	92674	54053	90481717
Night sweats	43.32	16.51	252	92425	128514	90407256
Chest pain	42.59	16.51	507	92170	319138	90216632
Anaemia	42.34	16.51	201	92476	352601	90183169
Blood pressure inadequately controlled	41.75	16.51	41	92636	6183	90529587
Gastrointestinal haemorrhage	41.73	16.51	20	92657	90228	90445542
Palpitations	41.63	16.51	47	92630	136681	90399089
Bursitis	41.31	16.51	253	92424	131401	90404369
Thrombosis	40.95	16.51	12	92665	73239	90462531
Ischaemic contracture of the left ventricle	40.63	16.51	12	92665	136	90535634
Osteoarthritis	40.41	16.51	340	92337	195390	90340380
Blood immunoglobulin A decreased	40.02	16.51	24	92653	1732	90534038
Epilepsy	39.65	16.51	178	92499	82028	90453742
Atrial fibrillation	39.52	16.51	47	92630	133564	90402206
Hyponatraemia	39.47	16.51	47	92630	133491	90402279
Blood pressure fluctuation	39.23	16.51	4	92673	52409	90483361
Incorrect dose administered	38.84	16.51	16	92661	78914	90456856
Laryngitis	38.58	16.51	127	92550	50626	90485144
Exercise tolerance decreased	38.57	16.51	43	92634	7508	90528262
Chills	38.43	16.51	47	92630	131934	90403836
Injection site pruritus	38.07	16.51	5	92672	53829	90481941
Suicidal ideation	37.95	16.51	14	92663	73841	90461929
Exostosis	37.77	16.51	130	92547	53004	90482766
Febrile neutropenia	37.65	16.51	65	92612	158284	90377486
Sepsis	37.36	16.51	80	92597	179734	90356036
Dry eye	37.31	16.51	7	92670	57924	90477846
Injection site erythema	36.91	16.51	28	92649	98474	90437296
White blood cell count decreased	36.71	16.51	72	92605	167037	90368733
Injection site bruising	36.65	16.51	5	92672	52302	90483468
Burning sensation	36.20	16.51	10	92667	63442	90472328
Oxygen saturation decreased	36.05	16.51	34	92643	107449	90428321
Thrombocytopenia	35.46	16.51	103	92574	208622	90327148
Infusion site reaction	35.28	16.51	67	92610	18972	90516798
Heart rate increased	35.26	16.51	38	92639	112864	90422906
Sedation	35.23	16.51	4	92673	48167	90487603
Headache	35.21	16.51	646	92031	862100	89673670
Treatment failure	34.91	16.51	469	92208	303459	90232311
Blood immunoglobulin M increased	34.55	16.51	20	92657	1352	90534418
Deep vein thrombosis	34.39	16.51	26	92651	91594	90444176
Lethargy	34.11	16.51	11	92666	63128	90472642
Dysphonia	34.07	16.51	11	92666	63073	90472697
Abdominal pain upper	34.05	16.51	503	92174	332171	90203599
Angioedema	33.84	16.51	12	92665	64864	90470906
Cardiac failure congestive	33.36	16.51	31	92646	98663	90437107
Musculoskeletal deformity	33.36	16.51	22	92655	1876	90533894
Gastrointestinal procedural complication	33.35	16.51	14	92663	468	90535302
Skin exfoliation	33.04	16.51	14	92663	67899	90467871
Vertigo	33.01	16.51	15	92662	69796	90465974
Eczema	32.77	16.51	7	92670	52863	90482907
Cardiac disorder	32.38	16.51	9	92668	56863	90478907
Lung disorder	32.34	16.51	263	92414	149620	90386150
Multiple sclerosis relapse	32.26	16.51	7	92670	52298	90483472
Lupus-like syndrome	31.71	16.51	116	92561	48730	90487040
Infection	31.21	16.51	532	92145	361562	90174208
Diarrhoea	31.01	16.51	728	91949	938462	89597308
Adverse event	30.95	16.51	216	92461	117202	90418568
Pulmonary embolism	30.82	16.51	54	92623	130766	90405004
Vascular access complication	30.81	16.51	23	92654	2390	90533380
Swollen tongue	30.80	16.51	5	92672	45951	90489819
Seizure	30.80	16.51	69	92608	152560	90383210
Product complaint	30.78	16.51	52	92625	13448	90522322
Hepatotoxicity	30.70	16.51	5	92672	45837	90489933
Macular degeneration	30.66	16.51	97	92580	37873	90497897
Herpes zoster	30.51	16.51	31	92646	94613	90441157
Red cell distribution width decreased	30.45	16.51	22	92655	2174	90533596
Drug intolerance	30.45	16.51	634	92043	446957	90088813
Renal failure	30.04	16.51	55	92622	130952	90404818
Musculoskeletal pain	29.97	16.51	287	92390	170964	90364806
Surgery	29.83	16.51	5	92672	44882	90490888
Disorientation	29.12	16.51	5	92672	44109	90491661
Red blood cell sedimentation rate increased	28.66	16.51	163	92514	82432	90453338
Cholelithiasis	28.63	16.51	9	92668	52497	90483273
Asthma	28.34	16.51	375	92302	241785	90293985
Cellulitis	28.23	16.51	31	92646	91306	90444464
Dyspnoea exertional	27.79	16.51	20	92657	72268	90463502
C-reactive protein abnormal	27.71	16.51	224	92453	127205	90408565
Multiple drug therapy	27.68	16.51	35	92642	6974	90528796
Hypotension	27.11	16.51	208	92469	325189	90210581
Orthostatic hypotension	27.05	16.51	5	92672	41822	90493948
Dysarthria	26.88	16.51	11	92666	54471	90481299
Full blood count abnormal	26.86	16.51	3	92674	36594	90499176
Speech disorder	26.35	16.51	7	92670	45578	90490192
Flushing	26.30	16.51	31	92646	88460	90447310
Hepatic cirrhosis	26.15	16.51	131	92546	63122	90472648
Psoriasis	26.04	16.51	248	92429	147506	90388264
Disturbance in attention	25.82	16.51	8	92669	47101	90488669
Hypothyroidism	25.77	16.51	11	92666	53116	90482654
Unevaluable event	25.59	16.51	12	92665	54836	90480934
Ankle arthroplasty	25.51	16.51	22	92655	2809	90532961
Eye pain	25.12	16.51	7	92670	44161	90491609
Femur fracture	24.95	16.51	8	92669	46074	90489696
Medication error	24.88	16.51	160	92517	84492	90451278
Sinus disorder	24.84	16.51	3	92674	34444	90501326
Product quality issue	24.60	16.51	152	92525	79173	90456597
Emotional distress	24.55	16.51	4	92673	36658	90499112
Hallucination	24.39	16.51	19	92658	65940	90469830
Haemorrhage	24.39	16.51	21	92656	69348	90466422
Frequent bowel movements	24.31	16.51	119	92558	56816	90478954
Seronegative arthritis	24.24	16.51	56	92621	18178	90517592
Asthenia	23.85	16.51	393	92284	533358	90002412
Dysgeusia	23.77	16.51	12	92665	52548	90483222
Throat irritation	23.75	16.51	10	92667	48685	90487085
Drug hypersensitivity	23.35	16.51	630	92047	462979	90072791
Overdose	23.17	16.51	83	92594	157626	90378144
Agranulocytosis	23.03	16.51	4	92673	34998	90500772
Chronic obstructive pulmonary disease	22.88	16.51	25	92652	73804	90461966
Mean platelet volume decreased	22.77	16.51	21	92656	2929	90532841
Angina pectoris	22.66	16.51	6	92671	39154	90496616
Blood immunoglobulin G increased	22.63	16.51	21	92656	2951	90532819
Skin reaction	22.52	16.51	55	92622	18498	90517272
Tinnitus	22.43	16.51	8	92669	43094	90492676
Depressed level of consciousness	22.17	16.51	25	92652	72759	90463011
Eye irritation	22.10	16.51	4	92673	33974	90501796
Ocular hyperaemia	21.94	16.51	4	92673	33794	90501976
Neoplasm progression	21.92	16.51	9	92668	44477	90491293
Skin ulcer	21.80	16.51	12	92665	50063	90485707
Adverse drug reaction	21.62	16.51	198	92479	116503	90419267
Red blood cell sedimentation rate abnormal	21.56	16.51	64	92613	24140	90511630
Renal disorder	21.53	16.51	6	92671	37853	90497917
Maternal exposure timing unspecified	21.52	16.51	61	92616	22422	90513348
Respiratory arrest	21.50	16.51	4	92673	33307	90502463
Joint dislocation	21.09	16.51	96	92581	44486	90491284
Coma	21.00	16.51	26	92651	72606	90463164
Genital erosion	20.98	16.51	10	92667	453	90535317
Posthaemorrhagic hydrocephalus	20.90	16.51	6	92671	61	90535709
Product prescribing error	20.84	16.51	3	92674	30142	90505628
Suicide attempt	20.75	16.51	28	92649	75371	90460399
Haematoma	20.75	16.51	7	92670	39041	90496729
Mental disorder	20.61	16.51	4	92673	32314	90503456
Skin disorder	20.54	16.51	6	92671	36700	90499070
Agitation	20.49	16.51	23	92654	67075	90468695
Blood creatinine increased	20.31	16.51	46	92631	101340	90434430
Renal impairment	20.19	16.51	49	92628	105372	90430398
Pain in jaw	20.18	16.51	12	92665	47973	90487797
Hepatitis	19.75	16.51	26	92651	70713	90465057
Oral herpes	19.66	16.51	5	92672	33519	90502251
Irritability	19.65	16.51	6	92671	35656	90500114
Diplopia	19.52	16.51	3	92674	28711	90507059
Eosinophilia	19.36	16.51	3	92674	28530	90507240
Foetal exposure during pregnancy	19.15	16.51	10	92667	42965	90492805
Suspected transmission of an infectious agent via product	19.12	16.51	9	92668	396	90535374
Therapeutic response decreased	19.11	16.51	157	92520	89572	90446198
Decreased appetite	19.03	16.51	512	92165	376028	90159742
Rash maculo-papular	19.03	16.51	9	92668	40924	90494846
Colitis ulcerative	19.01	16.51	116	92561	60150	90475620
Anaphylactic reaction	18.96	16.51	38	92639	87486	90448284
Product compounding quality issue	18.95	16.51	5	92672	36	90535734
Oral pain	18.93	16.51	5	92672	32678	90503092
Melaena	18.91	16.51	6	92671	34791	90500979
Platelet count decreased	18.87	16.51	74	92603	136895	90398875
Neck pain	18.79	16.51	57	92620	113906	90421864
Intentional product misuse	18.49	16.51	40	92637	89564	90446206
Grip strength	18.44	16.51	33	92644	8932	90526838
Rheumatic disorder	18.43	16.51	20	92657	3388	90532382
Blood pressure increased	18.39	16.51	122	92555	197095	90338675
Abdominal distension	18.36	16.51	70	92607	130531	90405239
Distributive shock	18.35	16.51	20	92657	3404	90532366
Respiratory tract congestion	18.33	16.51	3	92674	27407	90508363
Fluid retention	18.15	16.51	153	92524	87938	90447832
Neoplasm malignant	18.13	16.51	6	92671	33874	90501896
Rash erythematous	18.10	16.51	24	92653	65080	90470690
Breast cancer	18.03	16.51	17	92660	53744	90482026
Nodule	17.85	16.51	64	92613	26622	90509148
Dysuria	17.81	16.51	9	92668	39392	90496378
Blood pressure diastolic decreased	17.80	16.51	3	92674	26823	90508947
Citrate toxicity	17.66	16.51	3	92674	0	90535770
Haemoptysis	17.66	16.51	6	92671	33314	90502456
Aggression	17.65	16.51	3	92674	26665	90509105
Hepatocellular injury	17.61	16.51	4	92673	28954	90506816
Intestinal obstruction	17.52	16.51	8	92669	37123	90498647
Hot flush	17.51	16.51	21	92656	59467	90476303
Plasma cell myeloma	17.47	16.51	10	92667	40818	90494952
Pulmonary mass	17.44	16.51	4	92673	28768	90507002
Pulmonary hypertension	17.37	16.51	11	92666	42512	90493258
Premature delivery	17.30	16.51	9	92668	38753	90497017
Acute myocardial infarction	17.28	16.51	7	92670	34883	90500887
Mean cell volume decreased	17.00	16.51	22	92655	4484	90531286
Arthralgia	17.00	16.51	638	92039	777884	89757886
Polyglandular disorder	16.87	16.51	7	92670	227	90535543
Eating disorder	16.83	16.51	4	92673	28069	90507701
Nervousness	16.60	16.51	7	92670	34049	90501721

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	134.01	15.83	90	12984	26660	42581601
Blood phosphorus increased	72.11	15.83	46	13028	12479	42595782
Hypophosphataemia	69.61	15.83	55	13019	20890	42587371
Blood uric acid increased	67.68	15.83	48	13026	15499	42592762
Multiple organ dysfunction syndrome	66.44	15.83	112	12962	96923	42511338
Hyperphosphataemia	65.68	15.83	44	13030	12960	42595301
Lymphocyte count decreased	63.73	15.83	59	13015	27750	42580511
Hypocalcaemia	63.38	15.83	61	13013	30112	42578149
Appendicolith	61.96	15.83	43	13031	13413	42594848
Ventricular fibrillation	59.72	15.83	59	13015	30064	42578197
Myasthenia gravis	59.34	15.83	45	13029	16092	42592169
Appendicitis	53.67	15.83	47	13027	20566	42587695
Hypokalaemia	52.04	15.83	85	12989	71636	42536625
Cardiogenic shock	49.80	15.83	58	13016	35582	42572679
Blood cholesterol increased	46.85	15.83	49	13025	26692	42581569
Abdominal distension	46.70	15.83	81	12993	71654	42536607
Analgesic therapy	45.28	15.83	27	13047	6497	42601764
Sepsis	40.75	15.83	144	12930	199190	42409071
Hyponatraemia	38.98	15.83	92	12982	101370	42506891
Respiratory failure	36.66	15.83	104	12970	128028	42480233
Drug therapy	35.65	15.83	23	13051	6357	42601904
Iron deficiency	34.51	15.83	28	13046	11033	42597228
Sleep disorder therapy	34.02	15.83	23	13051	6871	42601390
Incorrect route of product administration	33.02	15.83	39	13035	24266	42583995
Hepatitis	32.54	15.83	41	13033	27259	42581002
Cytokine release syndrome	31.23	15.83	52	13022	44475	42563786
Total lung capacity decreased	30.73	15.83	17	13057	3553	42604708
Drug-induced liver injury	29.98	15.83	47	13027	38226	42570035
Diabetes mellitus	29.32	15.83	60	13014	60027	42548234
Dry mouth	28.54	15.83	47	13027	39832	42568429
Incision site pain	27.93	15.83	13	13061	1890	42606371
Red blood cells urine positive	27.89	15.83	13	13061	1897	42606364
Stress	27.55	15.83	49	13025	44163	42564098
Aspartate aminotransferase increased	27.51	15.83	68	13006	77095	42531166
Ascites	26.95	15.83	56	13018	56622	42551639
Neuralgia	26.65	15.83	36	13038	25611	42582650
Benign abdominal neoplasm	25.93	15.83	6	13068	90	42608171
Activated partial thromboplastin time prolonged	25.83	15.83	28	13046	15875	42592386
Bacterial infection	25.78	15.83	37	13037	27842	42580419
Blood creatinine increased	25.54	15.83	83	12991	109920	42498341
Protein urine present	25.44	15.83	18	13056	5783	42602478
BRASH syndrome	25.35	15.83	12	13062	1813	42606448
Blood test abnormal	25.05	15.83	25	13049	12881	42595380
Herpes zoster reactivation	24.99	15.83	8	13066	421	42607840
Drug hypersensitivity	24.91	15.83	77	12997	99312	42508949
Aortic stenosis	24.91	15.83	21	13053	8724	42599537
Hypoxia	24.34	15.83	61	13013	69725	42538536
Posthaemorrhagic hydrocephalus	24.31	15.83	6	13068	120	42608141
Chest expansion decreased	23.15	15.83	6	13068	147	42608114
Blood urea increased	22.60	15.83	38	13036	32755	42575506
Klebsiella infection	22.08	15.83	22	13052	11310	42596951
Scrotal pain	22.05	15.83	9	13065	954	42607307
Pantoea agglomerans infection	21.67	15.83	5	13069	74	42608187
Antacid therapy	21.53	15.83	15	13059	4702	42603559
Blood calcium increased	21.44	15.83	19	13055	8435	42599826
Hypercalcaemia	21.32	15.83	27	13047	18031	42590230
Carcinoid tumour of the small bowel	21.28	15.83	7	13067	402	42607859
Procedural pain	20.98	15.83	16	13058	5763	42602498
Neutrophil count increased	20.88	15.83	28	13046	19776	42588485
Product dose omission issue	20.35	15.83	11	13063	154354	42453907
Cyanosis	20.22	15.83	24	13050	15007	42593254
Cutaneous calcification	20.18	15.83	4	13070	27	42608234
Hypotension	19.81	15.83	141	12933	257490	42350771
Anticoagulant therapy	19.72	15.83	14	13060	4521	42603740
Central nervous system mass	19.64	15.83	8	13066	843	42607418
Wall motion score index abnormal	19.61	15.83	8	13066	847	42607414
Lactobacillus test positive	19.26	15.83	4	13070	35	42608226
Airway remodelling	19.21	15.83	8	13066	892	42607369
Transplant rejection	18.78	15.83	22	13052	13566	42594695
Bacteroides infection	18.72	15.83	11	13063	2576	42605685
Cardiac septal defect	18.71	15.83	8	13066	952	42607309
Lung opacity	18.68	15.83	15	13059	5822	42602439
Atopy	18.59	15.83	8	13066	967	42607294
Pleural effusion	17.95	15.83	68	13006	97098	42511163
Fungal sepsis	17.71	15.83	8	13066	1086	42607175
Hypothalamo-pituitary disorder	17.67	15.83	8	13066	1092	42607169
Completed suicide	17.61	15.83	4	13070	96461	42511800
Microangiopathy	17.25	15.83	9	13065	1673	42606588
Hyperkalaemia	17.15	15.83	59	13015	80399	42527862
Swelling	17.10	15.83	46	13028	54839	42553422
Weight increased	16.90	15.83	6	13068	107977	42500284
End stage renal disease	16.83	15.83	23	13051	16535	42591726
Drug abuse	16.10	15.83	6	13068	104765	42503496
Eosinophilic myocarditis	15.98	15.83	8	13066	1365	42606896
Delayed graft function	15.97	15.83	10	13064	2625	42605636
Immune effector cell-associated neurotoxicity syndrome	15.96	15.83	17	13057	9444	42598817

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid factor positive	319.27	15.22	442	82667	131198	110374992
Liver injury	302.20	15.22	462	82647	149951	110356239
Swollen joint count increased	290.46	15.22	336	82773	83325	110422865
Psoriatic arthropathy	283.87	15.22	521	82588	196240	110309950
Rheumatic fever	281.52	15.22	401	82708	122178	110384012
Pemphigus	273.55	15.22	539	82570	214031	110292159
Prescribed overdose	250.68	15.22	319	82790	87262	110418928
Anti-cyclic citrullinated peptide antibody positive	243.94	15.22	467	82642	181517	110324673
Hand deformity	230.63	15.22	508	82601	217998	110288192
Pericarditis	229.67	15.22	508	82601	218606	110287584
Rheumatoid arthritis	229.03	15.22	615	82494	298998	110207192
Fall	218.77	15.22	90	83019	603392	109902798
Fibromyalgia	217.36	15.22	429	82680	170480	110335710
Blood cholesterol increased	216.17	15.22	448	82661	184337	110321853
Lower limb fracture	207.07	15.22	269	82840	75079	110431111
Type 2 diabetes mellitus	198.35	15.22	422	82687	176810	110329380
Glossodynia	197.87	15.22	483	82626	221521	110284669
Lupus vulgaris	197.64	15.22	180	82929	33703	110472487
Oedema	195.90	15.22	465	82644	209511	110296679
Systemic lupus erythematosus	187.23	15.22	515	82594	253823	110252367
Dislocation of vertebra	187.07	15.22	196	82913	43525	110462665
Helicobacter infection	180.83	15.22	413	82696	181464	110324726
Prescribed underdose	173.37	15.22	229	82880	64945	110441245
Adjustment disorder with depressed mood	172.35	15.22	188	82921	43695	110462495
Mobility decreased	172.01	15.22	478	82631	236944	110269246
Duodenal ulcer perforation	165.15	15.22	393	82716	177307	110328883
Arthropathy	164.02	15.22	532	82577	286990	110219200
Synovitis	159.83	15.22	511	82598	273581	110232609
Wound	158.14	15.22	460	82649	233977	110272213
Drug interaction	157.73	15.22	90	83019	500093	110006097
Deep vein thrombosis postoperative	157.20	15.22	208	82901	59083	110447107
Injury	156.12	15.22	384	82725	176881	110329309
Muscle injury	156.04	15.22	334	82775	140473	110365717
Completed suicide	155.86	15.22	6	83103	242375	110263815
Death	151.04	15.22	182	82927	698687	109807503
Product dose omission issue	149.48	15.22	30	83079	321752	110184438
Wound infection	147.34	15.22	262	82847	96203	110409987
Lip dry	145.44	15.22	266	82843	99817	110406373
Discomfort	141.64	15.22	418	82691	214289	110291901
Joint range of motion decreased	137.30	15.22	291	82818	121541	110384649
Toxicity to various agents	137.05	15.22	97	83012	480458	110025732
Peripheral venous disease	135.65	15.22	234	82875	83883	110422307
Sciatica	134.79	15.22	246	82863	92153	110414037
Maternal exposure during pregnancy	128.88	15.22	453	82656	254430	110251760
Hip arthroplasty	125.71	15.22	181	82928	55632	110450558
Irritable bowel syndrome	125.23	15.22	337	82772	163878	110342312
Pulmonary fibrosis	123.49	15.22	251	82858	101791	110404399
Autoimmune disorder	122.83	15.22	195	82914	65288	110440902
Blister	120.06	15.22	410	82699	226966	110279224
Hypoaesthesia	119.28	15.22	510	82599	313713	110192477
Road traffic accident	114.67	15.22	251	82858	107147	110399043
Obesity	114.38	15.22	259	82850	113092	110393098
Knee arthroplasty	110.42	15.22	185	82924	64763	110441427
Alopecia	109.69	15.22	553	82556	364200	110141990
Swelling	109.66	15.22	538	82571	350503	110155687
Drug abuse	108.82	15.22	6	83103	177405	110328785
Amnesia	108.75	15.22	243	82866	105165	110401025
Joint destruction	107.99	15.22	79	83030	10864	110495326
Wheezing	105.26	15.22	425	82684	254805	110251385
Neutropenia	104.96	15.22	77	83032	374543	110131647
Facet joint syndrome	103.03	15.22	226	82883	96602	110409588
Contraindicated product administered	101.26	15.22	412	82697	247855	110258335
Breast cancer stage III	100.98	15.22	199	82910	78918	110427272
Retinitis	100.85	15.22	123	82986	32204	110473986
X-ray abnormal	98.38	15.22	132	82977	37985	110468205
COVID-19	98.07	15.22	31	83078	245029	110261161
Blepharospasm	92.92	15.22	156	82953	54695	110451495
Intentional product use issue	90.69	15.22	398	82711	247508	110258682
Hypocalcaemia	87.79	15.22	168	82941	65198	110440992
Hypercholesterolaemia	87.70	15.22	204	82905	90633	110415557
Grip strength decreased	87.42	15.22	189	82920	79985	110426205
Ulcer haemorrhage	87.40	15.22	96	83013	22475	110483715
Night sweats	84.65	15.22	257	82852	133726	110372464
Osteoarthritis	84.14	15.22	315	82794	182308	110323882
Gait inability	83.75	15.22	259	82850	136117	110370073
Sleep disorder due to general medical condition, insomnia type	83.74	15.22	220	82889	105423	110400767
Therapeutic product effect decreased	83.18	15.22	384	82725	243932	110262258
Treatment failure	83.06	15.22	420	82689	276814	110229376
Product use issue	82.97	15.22	457	82652	311238	110194952
Stomatitis	81.38	15.22	410	82699	269832	110236358
Sleep disorder	81.25	15.22	330	82779	198314	110307876
Foot deformity	79.63	15.22	136	82973	48344	110457846
Disease progression	79.61	15.22	42	83067	243992	110262198
Folliculitis	79.59	15.22	292	82817	167361	110338829
Taste disorder	79.28	15.22	161	82948	65226	110440964
Musculoskeletal stiffness	77.66	15.22	415	82694	279407	110226783
Hepatic enzyme increased	77.22	15.22	458	82651	320434	110185756
Lower respiratory tract infection	76.86	15.22	374	82735	242732	110263458
Drug tolerance decreased	75.12	15.22	98	83011	27442	110478748
Liver disorder	73.73	15.22	255	82854	141988	110364202
Drug intolerance	73.43	15.22	540	82569	405972	110100218
Acute kidney injury	72.76	15.22	240	82869	635190	109871000
C-reactive protein	72.18	15.22	101	83008	30230	110475960
Bone erosion	72.13	15.22	127	82982	46244	110459946
Abdominal discomfort	71.60	15.22	524	82585	393334	110112856
Influenza	70.17	15.22	20	83089	169081	110337109
Bursitis	70.04	15.22	236	82873	129682	110376508
Live birth	69.22	15.22	158	82951	69326	110436864
Infusion related reaction	69.22	15.22	507	82602	380655	110125535
Cough	68.90	15.22	153	82956	461488	110044702
Incorrect route of product administration	68.68	15.22	150	82959	63911	110442279
Injection site pain	68.56	15.22	24	83085	177898	110328292
Memory impairment	68.10	15.22	311	82798	196633	110309557
Toxic epidermal necrolysis	67.97	15.22	139	82970	56588	110449602
Anti-cyclic citrullinated peptide antibody	67.26	15.22	79	83030	19885	110486305
Therapy non-responder	66.45	15.22	264	82845	157043	110349147
Back pain	65.75	15.22	111	82998	370885	110135305
Musculoskeletal pain	64.76	15.22	291	82818	182732	110323458
Breast cancer stage II	63.43	15.22	90	83019	27285	110478905
Porphyria acute	62.75	15.22	74	83035	18706	110487484
Myocardial infarction	62.73	15.22	33	83076	192050	110314140
Impaired healing	62.42	15.22	303	82806	196414	110309776
Ill-defined disorder	62.09	15.22	258	82851	156595	110349595
Migraine	60.03	15.22	272	82837	171380	110334810
C-reactive protein abnormal	59.96	15.22	224	82885	129471	110376719
Exostosis	59.12	15.22	116	82993	45840	110460350
Walking aid user	58.93	15.22	83	83026	24992	110481198
Malignant neoplasm progression	58.48	15.22	29	83080	174538	110331652
Syncope	57.50	15.22	41	83068	202495	110303695
Hypertension	57.02	15.22	610	82499	509474	109996716
Interstitial lung disease	56.85	15.22	17	83092	139317	110366873
Drug tolerance	56.49	15.22	66	83043	16519	110489671
Adverse event	54.59	15.22	193	82916	108616	110397574
Laryngitis	54.49	15.22	107	83002	42304	110463886
Product quality issue	54.29	15.22	154	82955	77145	110429045
Dyspnoea	53.53	15.22	553	82556	1106319	109399871
Myalgia	53.33	15.22	53	83056	222328	110283862
Lung disorder	52.65	15.22	271	82838	179776	110326414
Lupus-like syndrome	52.51	15.22	103	83006	40689	110465501
Blood immunoglobulin A decreased	52.31	15.22	28	83081	2220	110503970
Urinary tract infection	52.12	15.22	104	83005	326178	110180012
Drug hypersensitivity	52.12	15.22	546	82563	453544	110052646
Inappropriate schedule of product administration	51.81	15.22	46	83063	203591	110302599
Delirium	51.80	15.22	220	82889	134805	110371385
Balance disorder	51.78	15.22	12	83097	116548	110389642
Cardiac failure congestive	50.71	15.22	25	83084	150975	110355215
Asthma	48.92	15.22	339	82770	249952	110256238
Epilepsy	48.78	15.22	176	82933	100033	110406157
Dry mouth	48.45	15.22	286	82823	199662	110306528
Product complaint	48.26	15.22	56	83053	13916	110492274
General physical health deterioration	48.16	15.22	510	82599	424785	110081405
Wrong technique in product usage process	47.79	15.22	5	83104	87343	110418847
Red blood cell sedimentation rate increased	47.39	15.22	148	82961	78154	110428036
Contusion	47.35	15.22	319	82790	233042	110273148
Pancytopenia	46.86	15.22	53	83056	209560	110296630
Joint dislocation	46.05	15.22	88	83021	34102	110472088
Blood pressure inadequately controlled	45.38	15.22	41	83068	7592	110498598
Disability	44.73	15.22	81	83028	30142	110476048
Cardiac failure	44.66	15.22	45	83064	187581	110318609
Joint swelling	44.19	15.22	518	82591	442327	110063863
Seronegative arthritis	44.15	15.22	52	83057	13125	110493065
Nasal congestion	43.89	15.22	10	83099	98272	110407918
Musculoskeletal deformity	43.77	15.22	22	83087	1531	110504659
Ischaemic contracture of the left ventricle	43.66	15.22	12	83097	144	110506046
Dry skin	42.37	15.22	14	83095	107639	110398551
Hyperhidrosis	42.26	15.22	47	83062	187251	110318939
Adverse drug reaction	41.27	15.22	173	82936	105386	110400804
Vision blurred	40.90	15.22	23	83086	128999	110377191
Cerebrovascular accident	40.34	15.22	46	83063	181238	110324952
Hepatic cirrhosis	40.17	15.22	127	82982	67499	110438691
Pregnancy	40.10	15.22	106	83003	50961	110455229
Feeling abnormal	40.06	15.22	46	83063	180665	110325525
Rhinorrhoea	39.28	15.22	14	83095	102652	110403538
Suicidal ideation	39.17	15.22	11	83098	93926	110412264
Eye injury	39.08	15.22	38	83071	7717	110498473
Gastrointestinal haemorrhage	39.05	15.22	40	83069	165478	110340712
Oropharyngeal pain	38.90	15.22	27	83082	135249	110370941
Dyspepsia	38.70	15.22	261	82848	190704	110315486
Blood phosphorus increased	38.27	15.22	54	83055	16286	110489904
Hypophosphataemia	38.21	15.22	80	83029	33102	110473088
Dehydration	38.18	15.22	97	83012	279414	110226776
Sedation	38.09	15.22	4	83105	69679	110436511
Blood immunoglobulin M increased	37.00	15.22	20	83089	1617	110504573
Febrile neutropenia	36.63	15.22	119	82990	316648	110189542
Vascular access complication	36.26	15.22	23	83086	2505	110503685
Red cell distribution width decreased	36.22	15.22	22	83087	2219	110503971
Maternal exposure timing unspecified	35.90	15.22	60	83049	20953	110485237
Drug reaction with eosinophilia and systemic symptoms	35.39	15.22	9	83100	82086	110424104
Productive cough	35.35	15.22	21	83088	114284	110391906
Hyperphosphataemia	35.24	15.22	52	83057	16329	110489861
Neuropathy peripheral	35.21	15.22	50	83059	179227	110326963
Incorrect dose administered	35.04	15.22	17	83092	103624	110402566
Fatigue	35.00	15.22	674	82435	1215284	109290906
Appendicolith	34.71	15.22	48	83061	14207	110491983
Exercise tolerance decreased	34.57	15.22	44	83065	12023	110494167
Multiple drug therapy	34.40	15.22	36	83073	7978	110498212
Gastrointestinal procedural complication	34.36	15.22	13	83096	452	110505738
Hepatotoxicity	33.75	15.22	4	83105	63396	110442794
Epistaxis	33.70	15.22	29	83080	130343	110375847
Infusion site reaction	33.62	15.22	53	83056	17629	110488561
Ankle arthroplasty	33.61	15.22	22	83087	2529	110503661
Polyarthritis	33.54	15.22	55	83054	18908	110487282
Somnolence	33.52	15.22	113	82996	297336	110208854
Dysphagia	33.07	15.22	40	83069	153560	110352630
Inflammation	32.74	15.22	253	82856	192985	110313205
Urticaria	32.68	15.22	375	82734	318482	110187708
Tremor	32.68	15.22	64	83045	202168	110304022
Erythema	32.65	15.22	111	82998	291336	110214854
Angioedema	32.03	15.22	17	83092	98483	110407707
Aggression	30.87	15.22	4	83105	59206	110446984
Serotonin syndrome	30.83	15.22	4	83105	59149	110447041
Hypersensitivity	30.42	15.22	449	82660	403549	110102641
Subcutaneous drug absorption impaired	30.39	15.22	33	83076	7626	110498564
Atrial fibrillation	30.36	15.22	81	83028	229561	110276629
Abdominal pain upper	30.33	15.22	398	82711	348713	110157477
Injection site swelling	30.30	15.22	5	83104	61785	110444405
Analgesic therapy	29.98	15.22	32	83077	7252	110498938
Medication error	29.68	15.22	157	82952	105209	110400981
Chest discomfort	28.97	15.22	54	83055	173794	110332396
Immunodeficiency	28.86	15.22	79	83030	38759	110467431
Dry eye	28.54	15.22	4	83105	55789	110450401
Mean platelet volume decreased	28.50	15.22	22	83087	3278	110502912
Deep vein thrombosis	28.49	15.22	38	83071	139849	110366341
Disorientation	28.15	15.22	9	83100	70662	110435528
Injection site reaction	28.05	15.22	16	83093	89054	110417136
Cellulitis	28.01	15.22	32	83077	125984	110380206
Injection site bruising	27.87	15.22	3	83106	51260	110454930
Hypothyroidism	27.79	15.22	10	83099	72889	110433301
Oxygen saturation decreased	27.75	15.22	47	83062	156935	110349255
Eosinophilia	27.73	15.22	5	83104	57931	110448259
Eczema	27.42	15.22	10	83099	72283	110433907
Tinnitus	27.35	15.22	6	83103	60534	110445656
Blood pressure fluctuation	27.30	15.22	11	83098	74813	110431377
Blood uric acid increased	27.27	15.22	54	83055	21475	110484715
Grip strength	27.25	15.22	34	83075	9107	110497083
Burning sensation	27.24	15.22	9	83100	69203	110436987
Orthostatic hypotension	27.17	15.22	8	83101	66241	110439949
Dyspnoea exertional	27.07	15.22	23	83086	104037	110402153
Coronary artery disease	27.05	15.22	10	83099	71680	110434510
Vertigo	26.80	15.22	16	83093	86854	110419336
Hypokalaemia	26.66	15.22	231	82878	182217	110323973
Infection	26.66	15.22	401	82708	361799	110144391
Lethargy	26.48	15.22	19	83090	93557	110412633
Disturbance in attention	26.33	15.22	7	83102	61988	110444202
Rhabdomyolysis	26.30	15.22	31	83078	120370	110385820
Blood calcium increased	26.25	15.22	48	83061	17992	110488198
Nausea	26.20	15.22	718	82391	1234972	109271218
Agranulocytosis	26.18	15.22	7	83102	61753	110444437
Palpitations	26.05	15.22	50	83059	159162	110347028
Agitation	25.90	15.22	28	83081	113023	110393167
Colitis ulcerative	25.85	15.22	121	82988	77242	110428948
Thrombocytopenia	25.79	15.22	155	82954	348730	110157460
Renal failure	25.57	15.22	86	83023	226488	110279702
Injection site pruritus	25.47	15.22	4	83105	51254	110454936
Swollen tongue	25.29	15.22	7	83102	60355	110445835
Lip swelling	25.07	15.22	4	83105	50663	110455527
Coma	25.05	15.22	31	83078	117838	110388352
Influenza like illness	24.95	15.22	18	83091	88394	110417796
General symptom	24.94	15.22	32	83077	8814	110497376
Myasthenia gravis	24.93	15.22	52	83057	21459	110484731
Citrate toxicity	24.78	15.22	4	83105	0	110506190
Hyperdynamic left ventricle	24.73	15.22	11	83098	581	110505609
Chills	24.60	15.22	68	83041	190512	110315678
Muscle spasms	24.52	15.22	318	82791	277839	110228351
Swelling face	24.52	15.22	20	83089	92301	110413889
Frequent bowel movements	24.10	15.22	112	82997	71278	110434912
Anaemia	24.07	15.22	279	82830	546807	109959383
Vaginal discharge	24.00	15.22	46	83063	17862	110488328
Osteoporosis	23.96	15.22	129	82980	87023	110419167
Skin ulcer	23.81	15.22	9	83100	63636	110442554
Renal impairment	23.76	15.22	68	83041	188377	110317813
Blood immunoglobulin G increased	23.72	15.22	21	83088	3787	110502403
Back disorder	23.58	15.22	50	83059	20872	110485318
Nail disorder	23.46	15.22	96	83013	57839	110448351
Dysphonia	23.40	15.22	14	83095	75915	110430275
Tubulointerstitial nephritis	23.30	15.22	6	83103	54278	110451912
Skin exfoliation	23.26	15.22	19	83090	87632	110418558
Drug therapy	23.16	15.22	28	83081	7263	110498927
Rheumatic disorder	22.76	15.22	20	83089	3571	110502619
Neoplasm progression	22.75	15.22	10	83099	64585	110441605
Urinary retention	22.70	15.22	12	83097	69671	110436519
Dysarthria	22.62	15.22	18	83091	84103	110422087
Sleep disorder therapy	22.61	15.22	28	83081	7443	110498747
Full blood count abnormal	22.57	15.22	7	83102	56045	110450145
Speech disorder	22.54	15.22	9	83100	61560	110444630
Ear infection	22.36	15.22	100	83009	62632	110443558
Seizure	22.29	15.22	88	83021	221097	110285093
Hallucination	22.28	15.22	26	83083	101406	110404784
Sinusitis	22.03	15.22	329	82780	296359	110209831
Pantoea agglomerans infection	21.74	15.22	7	83102	149	110506041
Cardiogenic shock	21.65	15.22	93	83016	57245	110448945
Haemoglobin decreased	21.41	15.22	105	83004	248622	110257568
Overlap syndrome	21.30	15.22	30	83079	9029	110497161
Therapy cessation	21.19	15.22	4	83105	44853	110461337
Palmar-plantar erythrodysaesthesia syndrome	20.85	15.22	3	83106	41022	110465168
Suspected transmission of an infectious agent via product	20.74	15.22	13	83096	1387	110504803
Multiple sclerosis relapse	20.73	15.22	6	83103	50234	110455956
Eye pain	20.64	15.22	6	83103	50093	110456097
Condition aggravated	20.55	15.22	709	82400	734127	109772063
Herpes zoster	20.52	15.22	31	83078	108348	110397842
C-reactive protein increased	20.42	15.22	252	82857	217667	110288523
Culture positive	20.33	15.22	12	83097	1149	110505041
Paraesthesia	20.28	15.22	306	82803	276215	110229975
Acute myocardial infarction	20.04	15.22	20	83089	83757	110422433
Red blood cell sedimentation rate	19.88	15.22	22	83087	5192	110500998
Product compounding quality issue	19.80	15.22	5	83104	42	110506148
Peripheral swelling	19.65	15.22	419	82690	403615	110102575
Endometritis	19.54	15.22	11	83098	963	110505227
Haematemesis	19.52	15.22	10	83099	59098	110447092
Diarrhoea	19.51	15.22	681	82428	1138824	109367366
Unresponsive to stimuli	19.33	15.22	12	83097	63778	110442412
Diplopia	19.24	15.22	4	83105	41890	110464300
Haematoma	19.15	15.22	10	83099	58466	110447724
Respiratory arrest	19.05	15.22	10	83099	58289	110447901
Incision site pain	18.95	15.22	17	83092	3118	110503072
Recalled product	18.77	15.22	11	83098	1039	110505151
Polyglandular disorder	18.62	15.22	7	83102	239	110505951
Genital erosion	18.59	15.22	10	83099	801	110505389
Nasopharyngitis	18.55	15.22	407	82702	393954	110112236
Angina pectoris	18.49	15.22	12	83097	62283	110443907
Arthritis	18.47	15.22	200	82909	167386	110338804
Therapeutic response decreased	18.42	15.22	130	82979	96369	110409821
BRASH syndrome	18.31	15.22	18	83091	3705	110502485
Neoplasm malignant	18.23	15.22	3	83106	37140	110469050
Spinal fusion surgery	18.18	15.22	28	83081	9128	110497062
Therapy partial responder	18.17	15.22	3	83106	37058	110469132
Melaena	18.13	15.22	15	83094	68742	110437448
Nail infection	18.10	15.22	15	83094	2473	110503717
Heart rate increased	18.06	15.22	52	83057	143782	110362408
Hypotension	18.01	15.22	281	82828	523568	109982622
Pallor	17.99	15.22	10	83099	56457	110449733
Ventricular fibrillation	17.97	15.22	70	83039	41243	110464947
Red blood cell count decreased	17.86	15.22	14	83095	65909	110440281
Depressed level of consciousness	17.73	15.22	36	83073	112242	110393948
Rash vesicular	17.66	15.22	36	83073	14616	110491574
Basal cell carcinoma	17.61	15.22	6	83103	45264	110460926
Dysgeusia	17.56	15.22	16	83093	69969	110436221
Vasculitis	17.38	15.22	3	83106	35870	110470320
Dysuria	17.34	15.22	12	83097	60219	110445971
Drug dependence	17.22	15.22	8	83101	50012	110456178
White blood cell count increased	17.07	15.22	128	82981	96714	110409476
Blood pressure increased	16.94	15.22	119	82990	258254	110247936
Physical disability	16.86	15.22	20	83089	5086	110501104
Injection site erythema	16.82	15.22	28	83081	94148	110412042
Mean cell volume decreased	16.66	15.22	21	83088	5681	110500509
Headache	16.57	15.22	521	82588	881856	109624334
Presyncope	16.55	15.22	8	83101	48879	110457311
Poor peripheral circulation	16.51	15.22	18	83091	4179	110502011
Device issue	16.48	15.22	3	83106	34532	110471658
Product prescribing error	16.48	15.22	9	83100	51322	110454868
Suicide attempt	16.45	15.22	33	83076	103361	110402829
Abortion spontaneous	16.32	15.22	3	83106	34279	110471911
Laboratory test abnormal	16.26	15.22	71	83038	44008	110462182
Hepatocellular injury	16.09	15.22	9	83100	50633	110455557
Distributive shock	16.08	15.22	21	83088	5883	110500307
Chest expansion decreased	15.93	15.22	6	83103	206	110505984
Irritability	15.92	15.22	8	83101	47801	110458389
Pustular psoriasis	15.90	15.22	33	83076	13572	110492618
Acne	15.81	15.22	3	83106	33517	110472673
Eye irritation	15.77	15.22	3	83106	33449	110472741
Mean cell haemoglobin decreased	15.76	15.22	23	83086	7151	110499039
Emotional distress	15.71	15.22	7	83102	44840	110461350
Chest pain	15.70	15.22	382	82727	375993	110130197
Gastric disorder	15.70	15.22	3	83106	33354	110472836
Hypercalcaemia	15.60	15.22	73	83036	46584	110459606
Decreased appetite	15.59	15.22	468	82641	475378	110030812
Appendicitis	15.59	15.22	52	83057	28412	110477778
Unevaluable event	15.52	15.22	13	83096	59214	110446976
Joint stiffness	15.51	15.22	95	83014	67148	110439042
Lactobacillus test positive	15.50	15.22	4	83105	37	110506153
Product use in unapproved indication	15.47	15.22	443	82666	446934	110059256
Hyperplastic cholecystopathy	15.38	15.22	6	83103	227	110505963
Pneumonitis	15.36	15.22	21	83088	76510	110429680
White blood cell count decreased	15.36	15.22	105	83004	229285	110276905
Blood pressure diastolic decreased	15.34	15.22	4	83105	35881	110470309
Cardiac disorder	15.25	15.22	21	83088	76259	110429931

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A12AA03	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS CALCIUM Calcium
ATC	B05XA19	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Electrolyte solutions
ATC	D11AX03	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:50646	bone density conservation agent
CHEBI has role	CHEBI:50733	nutraceutical

Related Drugs by ATC class:

A12AA Calcium 11 drugs

calcium carbonate calcium chloride calcium citrate calcium glubionate calcium glucoheptonate calcium glycerylphosphate calcium lactate calcium lactate gluconate calcium levulinate calcium pangamate calcium phosphate

B05XA Electrolyte solutions 18 drugs

ammonium chloride calcium chloride hydrochloric acid magnesium chloride magnesium phosphate magnesium sulfate potassium acetate potassium chloride potassium lactate potassium phosphate sodium acetate sodium bicarbonate show all 18 →

D11AX Other dermatologicals 20 drugs

aminobenzoic acid brimonidine caffeine deoxycholic acid diclofenac eflornithine finasteride gamolenic acid hydrogen peroxide hydroquinone ivermectin lithium succinate show all 20 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypocalcemia	indication	5291005
Osteoporosis	indication	64859006	DOID:11476
Hypocalcemic tetany	indication	190869004
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Alcoholism	contraindication	7200002
Poisoning by digitalis glycoside	contraindication	12876009
Peptic ulcer	contraindication	13200003	DOID:750
Constipation	contraindication	14760008	DOID:2089
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Hypervitaminosis D	contraindication	27712000	DOID:9971
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Conduction disorder of the heart	contraindication	44808001
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Heart disease	contraindication	56265001	DOID:114
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Poisoning by acetaminophen	contraindication	70273001
Agoraphobia	contraindication	70691001	DOID:593
Ventricular fibrillation	contraindication	71908006
Hypercalciuria	contraindication	71938000
Factor II deficiency	contraindication	73975000
Reye's syndrome	contraindication	74351001	DOID:14525
Gastrointestinal hemorrhage	contraindication	74474003
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Hemophilia	contraindication	90935002
Kidney stone	contraindication	95570007
Anemia due to enzyme deficiency	contraindication	111577008
von Willebrand disorder	contraindication	128105004	DOID:12531
Seizure disorder	contraindication	128613002
Obsessive-compulsive disorder	contraindication	191736004	DOID:10933
Insomnia	contraindication	193462001
Impaired renal function disorder	contraindication	197663003
Osteolysis	contraindication	203522001
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Panic disorder	contraindication	371631005	DOID:594
Breastfeeding (mother)	contraindication	413712001
Myocardial ischemia	contraindication	414795007	DOID:3393
Myocardial infarction in recovery phase	contraindication	418044006
Acute erosive gastritis	contraindication	444926003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018087	VUID
N0000146426	NUI
D00935	KEGG_DRUG
66905-23-5	SECONDARY_CAS_RN
4018087	VANDF
C0006699	UMLSCUI
CHEBI:3309	CHEBI
CHEMBL2106119	ChEMBL_ID
DB11126	DRUGBANK_ID
SQE6VB453K	UNII
9290	PUBCHEM_CID
1298846	RXNORM
20	MMSL
4337	MMSL
71865	MMSL
d03800	MMSL
000777	NDDF
007049	NDDF
387292008	SNOMEDCT_US
53691001	SNOMEDCT_US
D002125	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
calcium gluconate	Human Prescription Drug Label	1	0143-9180	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	23 sections
calcium gluconate	Human Prescription Drug Label	1	0143-9184	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	23 sections
calcium gluconate	Human Prescription Drug Label	1	0143-9185	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	22 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0264-5600	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9764	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	15 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9831	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	16 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9831	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	16 sections
Calcium Gluconate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	44567-620	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	44567-620	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	44567-621	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	44567-621	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate in Sodium Chloride	HUMAN PRESCRIPTION DRUG LABEL	1	44567-622	INJECTION, SOLUTION	10 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	44567-623	INJECTION, SOLUTION	100 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate	Human Prescription Drug Label	1	50090-3398	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	23 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1312	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	17 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1347	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	17 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	63323-360	INJECTION, SOLUTION	100 mg	INTRAVENOUS	NDA	25 sections
Calcium Gluconate	Human Prescription Drug Label	1	65145-170	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Calcium Gluconate	Human Prescription Drug Label	1	65145-171	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Calcium Gluconate	Human Prescription Drug Label	1	65145-172	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-162	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-164	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-630	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	25 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	68462-789	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	68462-790	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	68462-791	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	23 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	70069-727	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	21 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	70069-728	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	21 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	70518-4178	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	25 sections
calcium gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	70518-4355	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	23 sections

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calcium gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: