ammonium chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4350 12125-02-9

Description:

MoleculeDescription

Synonyms:

  • ammonium chloride
An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.
  • Molecular weight: 53.49
  • Formula: ClH4N
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
8.50 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 13, 1978 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood phosphorus increased 127.69 68.52 34 1319 7687 34947891
Appendicolith 124.05 68.52 34 1319 8567 34947011
Appendicitis 105.81 68.52 34 1319 14773 34940805
Stress 95.80 68.52 38 1315 30309 34925269
Ventricular fibrillation 91.22 68.52 34 1319 22920 34932658
Cardiogenic shock 86.32 68.52 34 1319 26584 34928994
Blood uric acid increased 85.00 68.52 26 1327 9598 34945980
Dry mouth 82.20 68.52 34 1319 30131 34925447
Myasthenia gravis 79.81 68.52 23 1330 6917 34948661

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 148.23 47.16 34 1481 8517 79734356
Blood phosphorus increased 141.78 47.16 34 1481 10313 79732560
Appendicitis 118.24 47.16 34 1481 20760 79722113
Ventricular fibrillation 103.87 47.16 34 1481 31892 79710981
Blood uric acid increased 94.83 47.16 26 1489 13334 79729539
Cardiogenic shock 94.80 47.16 34 1481 41880 79700993
Myasthenia gravis 86.79 47.16 23 1492 10376 79732497
Stress 86.46 47.16 38 1477 79574 79663299
Ascites 81.82 47.16 36 1479 75526 79667347
Analgesic therapy 71.83 47.16 13 1502 996 79741877
Sleep disorder therapy 71.64 47.16 13 1502 1011 79741862
Dry mouth 70.44 47.16 34 1481 87985 79654888
Drug therapy 69.57 47.16 13 1502 1188 79741685
Abdominal distension 63.33 47.16 35 1480 119615 79623258
Multiple organ dysfunction syndrome 63.16 47.16 35 1480 120211 79622662
Hyponatraemia 52.91 47.16 36 1479 177812 79565061
Iron deficiency 49.86 47.16 15 1500 10639 79732234
Hyperphosphataemia 47.96 47.16 13 1502 6363 79736510

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05XA04 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
ATC G04BA01 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Acidifiers
CHEBI has role CHEBI:173084 ferroptosis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cough indication 49727002
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Common cold indication 82272006 DOID:10459
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Hypocalcemia contraindication 5291005
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Pulmonary edema contraindication 19242006 DOID:11396
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Agoraphobia contraindication 70691001 DOID:593
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Peripheral edema contraindication 271809000
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Panic disorder contraindication 371631005 DOID:594
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Cough Indication

🐶 Veterinary products

ProductApplicantIngredients
Carafen Cough Syrup, Carafen Cough Tablets Zoetis Inc. 2
Carafen Cough Syrup, Carafen Cough Tablets Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018575 VUID
N0000146891 NUI
D01139 KEGG_DRUG
4018575 VANDF
C0002615 UMLSCUI
CHEBI:31206 CHEBI
CHEMBL1200939 ChEMBL_ID
D000643 MESH_DESCRIPTOR_UI
DB06767 DRUGBANK_ID
01Q9PC255D UNII
25517 PUBCHEM_CID
712 RXNORM
4182 MMSL
5668 MMSL
d00476 MMSL
000729 NDDF
002276 NDDF
419332007 SNOMEDCT_US
51366003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ecopp portable virus proection HUMAN OTC DRUG LABEL 2 42134-001 GRANULE 0.01 g EXTRACORPOREAL unapproved drug other 7 sections