potassium chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4199 7447-40-7

Description:

MoleculeDescription

Synonyms:

  • potassium chloride
A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
  • Molecular weight: 74.55
  • Formula: ClK
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 333.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 85 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Dec. 16, 1965 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 711.39 9.66 971 162562 818362 49623229
Contraindicated product administered 314.21 9.66 52 163481 148906 50292685
Hyperkalaemia 299.76 9.66 549 162984 47540 50394051
Hand deformity 298.26 9.66 5 163528 100194 50341397
Cardiac failure congestive 294.47 9.66 762 162771 83620 50357971
Systemic lupus erythematosus 292.38 9.66 51 163482 140571 50301020
Hypokalaemia 287.15 9.66 775 162758 87217 50354374
Rheumatoid arthritis 271.31 9.66 159 163374 202391 50239200
Joint swelling 257.40 9.66 248 163285 245038 50196553
Glossodynia 242.23 9.66 41 163492 115528 50326063
Alopecia 224.74 9.66 277 163256 244770 50196821
Acute kidney injury 213.89 9.66 1364 162169 226694 50214897
Therapeutic product effect decreased 213.72 9.66 86 163447 135964 50305627
Anti-cyclic citrullinated peptide antibody positive 212.27 9.66 3 163530 70584 50371007
Pneumonia 199.80 9.66 1982 161551 376419 50065172
Arthropathy 193.56 9.66 137 163396 157769 50283822
Maternal exposure during pregnancy 191.45 9.66 142 163391 159636 50281955
Off label use 183.21 9.66 850 162683 473576 49968015
Hypervolaemia 181.98 9.66 309 163224 25190 50416401
Wound 179.47 9.66 59 163474 105735 50335856
Infusion related reaction 179.41 9.66 170 163363 169387 50272204
Oedema peripheral 178.27 9.66 992 162541 156969 50284622
Atrial fibrillation 177.56 9.66 725 162808 101020 50340571
Blood potassium decreased 169.23 9.66 371 163162 36574 50405017
Pericarditis 169.16 9.66 26 163507 78663 50362928
Anaemia 168.05 9.66 1391 162142 251065 50190526
Drug intolerance 166.99 9.66 282 163251 218822 50222769
Dehydration 164.50 9.66 946 162587 151503 50290088
Lower respiratory tract infection 161.64 9.66 53 163480 95148 50346443
Pulmonary hypertension 160.41 9.66 342 163191 33075 50408516
Drug hypersensitivity 153.69 9.66 367 163166 250643 50190948
Plasma cell myeloma 149.70 9.66 320 163213 31002 50410589
Abdominal discomfort 139.17 9.66 342 163191 231299 50210292
Discomfort 138.15 9.66 90 163443 108290 50333301
Pulmonary arterial hypertension 138.12 9.66 241 163292 20078 50421513
Treatment failure 137.53 9.66 145 163388 137492 50304099
Pain 135.32 9.66 1209 162324 577694 49863897
Arthralgia 127.27 9.66 863 162670 437839 50003752
Diarrhoea 123.80 9.66 2623 160910 585853 49855738
Synovitis 123.18 9.66 131 163402 123734 50317857
Gastrointestinal haemorrhage 122.78 9.66 516 163017 72805 50368786
Duodenal ulcer perforation 122.25 9.66 6 163527 45605 50395986
Musculoskeletal stiffness 122.15 9.66 141 163392 128340 50313251
Product use issue 119.80 9.66 186 163347 149289 50292302
Right ventricular failure 119.26 9.66 197 163336 15696 50425895
Helicobacter infection 117.55 9.66 12 163521 49690 50391901
Toxic anterior segment syndrome 116.39 9.66 69 163464 1496 50440095
Toxicity to various agents 112.35 9.66 334 163199 212165 50229426
Exposure during pregnancy 111.62 9.66 136 163397 120879 50320712
Dyspnoea 110.62 9.66 2427 161106 545181 49896410
Fluid retention 109.86 9.66 387 163146 50262 50391329
Swelling 108.16 9.66 313 163220 200559 50241032
Acute respiratory failure 106.61 9.66 266 163267 28516 50413075
Colitis microscopic 101.26 9.66 115 163418 6405 50435186
Hypoxia 101.05 9.66 379 163154 50744 50390847
Drug abuse 98.64 9.66 35 163498 59811 50381780
Rash 96.23 9.66 927 162606 436544 50005047
Respiratory failure 95.76 9.66 562 162971 90619 50350972
Hepatic enzyme increased 92.90 9.66 190 163343 137190 50304401
Sepsis 91.79 9.66 739 162794 132186 50309405
Therapeutic product effect incomplete 90.73 9.66 97 163436 91418 50350173
Hypotension 90.52 9.66 1160 162373 234309 50207282
Muscle injury 90.31 9.66 8 163525 37103 50404488
Renal failure 86.65 9.66 616 162917 106017 50335574
Product residue present 86.46 9.66 81 163452 3591 50438000
Asthenia 85.93 9.66 1478 162055 317564 50124027
Folliculitis 84.19 9.66 13 163520 39212 50402379
International normalised ratio increased 83.69 9.66 318 163215 42834 50398757
Hypersensitivity 82.43 9.66 386 163147 214775 50226816
Pneumonia aspiration 81.62 9.66 253 163280 30751 50410840
Pleural effusion 79.75 9.66 493 163040 80961 50360630
Chronic obstructive pulmonary disease 79.49 9.66 363 163170 53072 50388519
Device expulsion 76.57 9.66 4 163529 28818 50412773
Completed suicide 75.80 9.66 199 163334 131690 50309901
Abortion spontaneous 74.95 9.66 21 163512 41751 50399840
Deep vein thrombosis 72.59 9.66 445 163088 72859 50368732
Fall 72.38 9.66 1500 162033 333432 50108159
Cardiac failure 71.18 9.66 455 163078 75585 50366006
Hyponatraemia 71.03 9.66 543 162990 95596 50345995
Oedema 68.21 9.66 424 163109 69757 50371834
Irritable bowel syndrome 67.89 9.66 41 163492 51400 50390191
Injection site pain 65.73 9.66 165 163368 110859 50330732
Gastrooesophageal reflux disease 62.34 9.66 442 163091 75986 50365605
Death 60.07 9.66 1425 162108 323954 50117637
Impaired healing 55.71 9.66 87 163446 69699 50371892
Electrolyte imbalance 55.69 9.66 151 163382 17018 50424573
Bronchitis 54.37 9.66 545 162988 103614 50337977
Full blood count decreased 53.93 9.66 177 163356 22169 50419422
Product use in unapproved indication 52.24 9.66 195 163338 115624 50325967
Ill-defined disorder 50.81 9.66 61 163472 54593 50386998
Nasopharyngitis 50.66 9.66 390 163143 192537 50249054
Cytokine release syndrome 50.54 9.66 96 163437 8538 50433053
Injection site swelling 50.13 9.66 37 163496 41736 50399855
Glaucoma 49.93 9.66 137 163396 15549 50426042
Pulmonary oedema 49.65 9.66 299 163234 48639 50392952
Injection site erythema 49.48 9.66 105 163428 74831 50366760
Psoriatic arthropathy 46.43 9.66 50 163483 46982 50394609
C-reactive protein abnormal 46.27 9.66 16 163517 27793 50413798
Dyspnoea exertional 45.75 9.66 303 163230 50930 50390661
Thrombocytopenia 45.64 9.66 621 162912 127052 50314539
Pulmonary embolism 45.53 9.66 516 163017 101188 50340403
Injection site reaction 44.25 9.66 58 163475 49974 50391617
Urinary tract infection 44.03 9.66 990 162543 223030 50218561
Diverticulitis 43.24 9.66 217 163316 32965 50408626
Haemoglobin decreased 43.13 9.66 613 162920 126603 50314988
Blister 43.12 9.66 137 163396 85281 50356310
Injection site bruising 42.30 9.66 34 163499 36734 50404857
Brain natriuretic peptide increased 42.17 9.66 62 163471 4465 50437126
Atrial flutter 41.25 9.66 89 163444 8674 50432917
Dementia 40.68 9.66 129 163404 15868 50425723
Cor pulmonale 39.47 9.66 39 163494 1848 50439743
Transfusion 38.41 9.66 110 163423 12795 50428796
Hypomagnesaemia 37.98 9.66 162 163371 22994 50418597
Syncope 37.21 9.66 502 163031 102500 50339091
Pregnancy 37.07 9.66 25 163508 29552 50412039
Febrile neutropenia 36.52 9.66 479 163054 97188 50344403
Hip arthroplasty 36.45 9.66 27 163506 30402 50411189
Metabolic encephalopathy 36.45 9.66 62 163471 5059 50436532
Catheter management 35.42 9.66 44 163489 2695 50438896
Gastrointestinal disorder 34.63 9.66 172 163361 94284 50347307
Suicide attempt 34.55 9.66 72 163461 51660 50389931
Cerebrovascular accident 34.43 9.66 462 163071 94218 50347373
Pancytopenia 34.35 9.66 419 163114 83611 50357980
Decreased appetite 34.31 9.66 871 162662 200052 50241539
Intentional self-injury 34.05 9.66 16 163517 23096 50418495
Wrong technique in product usage process 34.01 9.66 81 163452 55429 50386162
Clostridium difficile colitis 33.77 9.66 130 163403 17612 50423979
Oxygen consumption increased 33.77 9.66 49 163484 3487 50438104
Hyperaldosteronism 33.33 9.66 16 163517 222 50441369
Blood bilirubin increased 33.29 9.66 197 163336 31841 50409750
Haematoma 33.26 9.66 190 163343 30320 50411271
Intentional overdose 33.14 9.66 98 163435 62406 50379185
Blood loss anaemia 33.10 9.66 78 163455 8061 50433530
Thrombosis 32.50 9.66 299 163234 55534 50386057
Urticaria 32.09 9.66 266 163267 129295 50312296
Mental status changes 32.07 9.66 214 163319 36058 50405533
Infection 32.01 9.66 381 163152 172573 50269018
Sinusitis 31.85 9.66 375 163158 170183 50271408
Disease progression 31.71 9.66 460 163073 95406 50346185
Suicidal ideation 31.47 9.66 84 163449 55301 50386290
Drug resistance 31.46 9.66 11 163522 18978 50422613
Respiratory distress 31.38 9.66 187 163346 30302 50411289
Cardiac failure acute 31.34 9.66 77 163456 8173 50433418
Psoriasis 31.21 9.66 116 163417 68884 50372707
Neuropathy peripheral 31.11 9.66 462 163071 96295 50345296
Accidental exposure to product 30.95 9.66 18 163515 23039 50418552
Subileus 30.47 9.66 41 163492 2718 50438873
Red blood cell sedimentation rate increased 30.47 9.66 30 163503 29386 50412205
Rheumatoid nodule 30.30 9.66 3 163530 12732 50428859
Endophthalmitis 30.20 9.66 42 163491 2874 50438717
Ascites 30.17 9.66 209 163324 35652 50405939
Peritonitis bacterial 30.01 9.66 54 163479 4607 50436984
Cardiomegaly 29.67 9.66 116 163417 15829 50425762
Injection site pruritus 28.92 9.66 54 163479 40357 50401234
Intentional product use issue 28.81 9.66 139 163394 76779 50364812
Septic shock 28.78 9.66 297 163236 56878 50384713
Hyperkaliuria 28.69 9.66 10 163523 56 50441535
Mobility decreased 28.50 9.66 147 163386 79801 50361790
Blood urea increased 28.47 9.66 151 163382 23434 50418157
Coma 28.41 9.66 295 163238 56584 50385007
Blood cholesterol increased 28.25 9.66 88 163445 55127 50386464
Chest pain 27.65 9.66 758 162775 176124 50265467
Acute motor-sensory axonal neuropathy 27.63 9.66 15 163518 273 50441318
Sleep disorder 27.44 9.66 94 163439 57189 50384402
Encephalopathy 26.91 9.66 194 163339 33517 50408074
Loss of personal independence in daily activities 26.58 9.66 126 163407 69924 50371667
Cardiac arrest 26.33 9.66 398 163135 83253 50358338
Arrhythmia 26.07 9.66 190 163343 32942 50408649
Gout 26.03 9.66 89 163444 11381 50430210
Joint stiffness 25.92 9.66 36 163497 30272 50411319
Blood magnesium decreased 25.69 9.66 87 163446 11073 50430518
Blood alkaline phosphatase increased 25.52 9.66 208 163325 37318 50404273
Electrocardiogram U wave present 25.35 9.66 10 163523 83 50441508
Epistaxis 25.31 9.66 317 163216 63637 50377954
Melaena 25.27 9.66 161 163372 26703 50414888
Condition aggravated 25.23 9.66 749 162784 296309 50145282
Metabolic alkalosis 24.86 9.66 37 163496 2694 50438897
Knee arthroplasty 24.69 9.66 49 163484 35797 50405794
Serotonin syndrome 24.69 9.66 26 163507 24687 50416904
Blood potassium abnormal 24.63 9.66 33 163500 2179 50439412
Arthritis 24.32 9.66 172 163361 86549 50355042
Headache 23.81 9.66 1367 162166 505168 49936423
Colitis 23.78 9.66 209 163324 38320 50403271
Constipation 23.66 9.66 776 162757 184932 50256659
Orthopnoea 23.66 9.66 55 163478 5634 50435957
Therapeutic response decreased 23.65 9.66 76 163457 47155 50394436
Drug eruption 23.40 9.66 25 163508 23581 50418010
Platelet count decreased 23.28 9.66 456 163077 100270 50341321
Acute left ventricular failure 23.05 9.66 20 163513 801 50440790
Foetal exposure during pregnancy 22.90 9.66 33 163500 27326 50414265
Cardioactive drug level increased 22.71 9.66 30 163503 1954 50439637
Calcium deficiency 22.45 9.66 21 163512 929 50440662
Prothrombin time prolonged 22.22 9.66 71 163462 8767 50432824
Blood pressure fluctuation 22.16 9.66 52 163481 35771 50405820
Hypernatraemia 21.93 9.66 57 163476 6264 50435327
Haemoptysis 21.48 9.66 149 163384 25424 50416167
Left ventricular failure 21.46 9.66 48 163485 4793 50436798
Malnutrition 21.42 9.66 92 163441 13097 50428494
Supraventricular tachycardia 21.33 9.66 90 163443 12711 50428880
Generalised oedema 20.94 9.66 94 163439 13637 50427954
Pseudomonal bacteraemia 20.91 9.66 23 163510 1236 50440355
Immune effector cell-associated neurotoxicity syndrome 20.84 9.66 22 163511 1128 50440463
Stomatitis 20.81 9.66 218 163315 101126 50340465
Confusion postoperative 20.67 9.66 11 163522 192 50441399
Cellulitis 20.44 9.66 332 163201 70466 50371125
Product selection error 19.72 9.66 8 163525 72 50441519
Bezoar 19.63 9.66 23 163510 1325 50440266
Tenosynovitis 19.54 9.66 5 163528 10560 50431031
Haematocrit decreased 19.20 9.66 185 163348 34791 50406800
Urine chloride decreased 19.16 9.66 8 163525 78 50441513
Cholestasis 19.03 9.66 144 163389 25257 50416334
White blood cell count decreased 19.02 9.66 503 163030 116219 50325372
Hypocalcaemia 18.97 9.66 150 163383 26666 50414925
Congenital osteodystrophy 18.66 9.66 6 163527 25 50441566
Tonsillar haemorrhage 18.66 9.66 11 163522 236 50441355
Inflammation 18.44 9.66 108 163425 56804 50384787
Oxygen saturation decreased 18.44 9.66 336 163197 72912 50368679
Troponin increased 18.43 9.66 63 163470 8055 50433536
Body height decreased 18.39 9.66 67 163466 8841 50432750
Alkalosis hypochloraemic 18.19 9.66 9 163524 134 50441457
Product compounding quality issue 18.11 9.66 6 163527 28 50441563
Pulmonary arterial pressure increased 18.10 9.66 36 163497 3312 50438279
Weight decreased 18.02 9.66 881 162652 220364 50221227
Lower gastrointestinal haemorrhage 17.97 9.66 56 163477 6823 50434768
Abdominal distension 17.85 9.66 333 163200 72570 50369021
Impaired work ability 17.81 9.66 11 163522 13629 50427962
Subdural haematoma 17.81 9.66 86 163447 12861 50428730
Electrocardiogram T wave peaked 17.76 9.66 10 163523 196 50441395
Arteriovenous malformation 17.55 9.66 21 163512 1237 50440354
Head injury 17.34 9.66 135 163398 23885 50417706
Chronic respiratory failure 17.30 9.66 24 163509 1638 50439953
Hepatotoxicity 17.26 9.66 39 163494 27187 50414404
Inappropriate schedule of product administration 17.09 9.66 149 163384 71682 50369909
Bradycardia 17.09 9.66 298 163235 64128 50377463
Acne 17.03 9.66 23 163510 19572 50422019
Liver injury 17.01 9.66 34 163499 24772 50416819
Anterior chamber inflammation 16.93 9.66 11 163522 282 50441309
Failure to thrive 16.84 9.66 52 163481 6306 50435285
Clostridium difficile infection 16.75 9.66 140 163393 25299 50416292
Rectal haemorrhage 16.51 9.66 194 163339 38364 50403227
Prothrombin consumption time prolonged 16.47 9.66 6 163527 39 50441552
Atelectasis 16.27 9.66 108 163425 18162 50423429
Anaphylactic reaction 16.25 9.66 105 163428 53950 50387641
Foot deformity 16.25 9.66 23 163510 19187 50422404
Injection site rash 16.18 9.66 17 163516 16160 50425431
Altered visual depth perception 16.17 9.66 11 163522 305 50441286
Blood albumin decreased 16.15 9.66 85 163448 13151 50428440
Hypovolaemia 16.13 9.66 67 163466 9398 50432193
Mental status changes postoperative 16.09 9.66 9 163524 174 50441417
Nodal arrhythmia 16.07 9.66 19 163514 1105 50440486
Hospice care 16.03 9.66 48 163485 5724 50435867
Polyuria 15.94 9.66 55 163478 7066 50434525
Device difficult to use 15.92 9.66 6 163527 9880 50431711
Pericardial effusion 15.89 9.66 139 163394 25450 50416141
Blood potassium increased 15.87 9.66 99 163434 16299 50425292
Nodule 15.77 9.66 19 163514 16984 50424607
Injection site warmth 15.73 9.66 13 163520 13853 50427738
Paracentesis 15.68 9.66 17 163516 899 50440692
Unevaluable event 15.60 9.66 222 163311 45844 50395747
Live birth 15.58 9.66 18 163515 16390 50425201
Grip strength decreased 15.52 9.66 10 163523 12111 50429480
Gastritis 15.50 9.66 169 163364 32814 50408777
Blood chloride decreased 15.46 9.66 43 163490 4918 50436673
Purging 15.40 9.66 6 163527 48 50441543
Presyncope 15.32 9.66 132 163401 24066 50417525
Hypercapnia 15.31 9.66 41 163492 4586 50437005
Catheter site infection 15.23 9.66 39 163494 4247 50437344
Obstructive airways disorder 15.05 9.66 17 163516 15635 50425956
Occult blood positive 15.00 9.66 33 163500 3258 50438333
Device related sepsis 14.90 9.66 34 163499 3441 50438150
Activated partial thromboplastin time prolonged 14.81 9.66 50 163483 6352 50435239
Drug ineffective for unapproved indication 14.74 9.66 29 163504 21252 50420339
Schizophrenia 14.68 9.66 3 163530 7394 50434197
Vascular device infection 14.66 9.66 39 163494 4345 50437246
Arteriosclerosis coronary artery 14.57 9.66 56 163477 7580 50434011
Thyroid disorder 14.51 9.66 80 163453 12597 50428994
Urine sodium decreased 14.38 9.66 8 163525 153 50441438
Cardiac disorder 14.11 9.66 206 163327 42773 50398818
Vascular encephalopathy 14.09 9.66 11 163522 379 50441212
Cardiorenal syndrome 14.07 9.66 13 163520 566 50441025
Hyperthyroidism 14.05 9.66 77 163456 12098 50429493
Ankylosing spondylitis 14.03 9.66 3 163530 7162 50434429
Ageusia 13.87 9.66 74 163459 11509 50430082
Laboratory test abnormal 13.86 9.66 125 163408 23083 50418508
Cytomegalovirus infection 13.76 9.66 23 163510 17939 50423652
Congenital bowing of long bones 13.73 9.66 6 163527 66 50441525
Hypoxic-ischaemic encephalopathy 13.69 9.66 35 163498 3807 50437784
Transplant rejection 13.63 9.66 7 163526 9602 50431989
Depressed mood 13.62 9.66 60 163473 33963 50407628
Lymphoedema 13.58 9.66 62 163471 9060 50432531
Blood creatinine increased 13.52 9.66 332 163201 75828 50365763
Cataract operation complication 13.48 9.66 7 163526 116 50441475
Hypophagia 13.46 9.66 143 163390 27585 50414006
Skin dystrophy 13.41 9.66 5 163528 35 50441556
Pulse absent 13.38 9.66 40 163493 4766 50436825
Vascular purpura 13.35 9.66 18 163515 1196 50440395
Disability 13.26 9.66 13 163520 12762 50428829
Cholelithiasis 13.26 9.66 184 163349 37789 50403802
Chronic kidney disease 13.20 9.66 191 163342 39580 50402011
Cardiogenic shock 13.17 9.66 91 163442 15508 50426083
Subclavian vein thrombosis 13.09 9.66 22 163511 1777 50439814
Lung infiltration 13.05 9.66 81 163452 13312 50428279
Oropharyngeal pain 13.03 9.66 175 163358 77626 50363965
Joint range of motion decreased 13.01 9.66 25 163508 18487 50423104
Abortion induced 12.97 9.66 7 163526 9337 50432254
Multiple allergies 12.96 9.66 58 163475 8405 50433186
Aspartate aminotransferase increased 12.95 9.66 337 163196 77661 50363930
Tracheal obstruction 12.92 9.66 6 163527 77 50441514
Oesophageal spasm 12.79 9.66 25 163508 2271 50439320
Haemorrhage 12.70 9.66 243 163290 53198 50388393
Herpes zoster 12.67 9.66 157 163376 70629 50370962
Leukocytosis 12.67 9.66 120 163413 22459 50419132
Oesophageal pain 12.67 9.66 28 163505 2774 50438817
Wrong patient received product 12.65 9.66 21 163512 1679 50439912
Mood swings 12.62 9.66 20 163513 15934 50425657
Ovarian cyst 12.61 9.66 16 163517 13980 50427611
Blood cholesterol decreased 12.58 9.66 14 163519 762 50440829
Anterior chamber disorder 12.58 9.66 6 163527 82 50441509
Device related infection 12.55 9.66 112 163421 20623 50420968
Mitral valve incompetence 12.51 9.66 98 163435 17373 50424218
Polyarthritis 12.45 9.66 5 163528 7922 50433669
Right atrial pressure increased 12.40 9.66 7 163526 138 50441453
Panniculitis 12.35 9.66 6 163527 8497 50433094
Wrong strength 12.32 9.66 5 163528 45 50441546
Muscle spasticity 12.26 9.66 23 163510 17161 50424430
Depressed level of consciousness 12.25 9.66 108 163425 51845 50389746
Sedation 12.24 9.66 54 163479 30556 50411035
Oral herpes 12.10 9.66 31 163502 20694 50420897
Nail dystrophy 12.08 9.66 14 163519 797 50440794
Bacteraemia 12.07 9.66 84 163449 14349 50427242
Coronary artery disease 12.04 9.66 148 163385 29578 50412013
Acute pulmonary oedema 12.04 9.66 51 163482 7216 50434375
Pharyngitis 11.99 9.66 24 163509 17479 50424112
Small intestinal obstruction 11.99 9.66 91 163442 15977 50425614
Somnolence 11.96 9.66 614 162919 154371 50287220
Uterine perforation 11.93 9.66 3 163530 6412 50435179
Enterococcus test positive 11.92 9.66 16 163517 1058 50440533
Blood glucose decreased 11.87 9.66 100 163433 18111 50423480
Hypoalbuminaemia 11.81 9.66 63 163470 9797 50431794
Blood calcium abnormal 11.78 9.66 16 163517 1070 50440521
Urosepsis 11.77 9.66 88 163445 15377 50426214
Nasal congestion 11.66 9.66 231 163302 50889 50390702
Muscle haemorrhage 11.65 9.66 28 163505 2930 50438661
Blood pressure systolic increased 11.63 9.66 67 163466 35382 50406209
Osteoarthritis 11.60 9.66 154 163379 68452 50373139
Cardiac amyloidosis 11.53 9.66 13 163520 718 50440873
Cerebral haemorrhage 11.53 9.66 136 163397 26916 50414675
Paralysis recurrent laryngeal nerve 11.52 9.66 5 163528 54 50441537
Subclavian artery thrombosis 11.40 9.66 7 163526 162 50441429
Sopor 11.40 9.66 30 163503 19849 50421742
Retinal ischaemia 11.38 9.66 9 163524 316 50441275
Congestive hepatopathy 11.36 9.66 25 163508 2469 50439122
Bacillus bacteraemia 11.29 9.66 5 163528 57 50441534
Type 2 diabetes mellitus 11.26 9.66 65 163468 34310 50407281
Catheter placement 11.23 9.66 22 163511 2002 50439589
Poor peripheral circulation 11.20 9.66 29 163504 3179 50438412
Blood pressure diastolic increased 11.20 9.66 5 163528 7438 50434153
Incision site pain 11.13 9.66 15 163518 996 50440595
Fear of injection 11.07 9.66 3 163530 6100 50435491
Abortion incomplete complicated 10.94 9.66 3 163530 6 50441585
Deposit eye 10.94 9.66 3 163530 6 50441585
Pneumothorax spontaneous 10.92 9.66 12 163521 644 50440947
Sinoatrial block 10.91 9.66 13 163520 762 50440829
Dermatitis exfoliative 10.89 9.66 39 163494 5103 50436488
Demyelination 10.86 9.66 3 163530 6023 50435568
Emphysema 10.83 9.66 58 163475 9035 50432556
Electrocardiogram abnormal 10.81 9.66 51 163482 7554 50434037
Polyneuropathy 10.79 9.66 14 163519 12117 50429474
Electrocardiogram U-wave abnormality 10.73 9.66 4 163529 28 50441563
Serratia test positive 10.73 9.66 4 163529 28 50441563
Lung perforation 10.71 9.66 5 163528 65 50441526
Red blood cell count decreased 10.65 9.66 161 163372 33674 50407917
Acute coronary syndrome 10.63 9.66 59 163474 9315 50432276
Pseudomonal sepsis 10.61 9.66 22 163511 2085 50439506
Blood albumin abnormal 10.60 9.66 10 163523 447 50441144
Peptic ulcer 10.59 9.66 32 163501 3834 50437757
Transplant evaluation 10.58 9.66 15 163518 1045 50440546
Catheter site extravasation 10.44 9.66 8 163525 268 50441323
Drug-induced liver injury 10.38 9.66 51 163482 28044 50413547
Dystonia 10.37 9.66 14 163519 11912 50429679
Catheter culture positive 10.33 9.66 6 163527 125 50441466
Cytotoxic oedema 10.29 9.66 6 163527 126 50441465
Pain in jaw 10.28 9.66 178 163355 38250 50403341
Blood sodium decreased 10.23 9.66 109 163424 21038 50420553
Renal tubular necrosis 10.23 9.66 62 163471 10106 50431485
Alkalosis 10.22 9.66 8 163525 277 50441314
Cerebral ventricular rupture 10.20 9.66 7 163526 197 50441394
Pickwickian syndrome 10.19 9.66 8 163525 278 50441313
Colour blindness 10.17 9.66 8 163525 279 50441312
Blood glucose increased 10.11 9.66 302 163231 71022 50370569
Bladder outlet obstruction 10.08 9.66 3 163530 9 50441582
Toxic epidermal necrolysis 10.07 9.66 108 163425 20884 50420707
Hiatus hernia 10.05 9.66 97 163436 18247 50423344
Thyroxine decreased 10.05 9.66 10 163523 478 50441113
Neonatal infection 10.00 9.66 6 163527 133 50441458
Injection site urticaria 9.97 9.66 15 163518 12202 50429389
Fibromyalgia 9.96 9.66 95 163438 44883 50396708
Blood chloride abnormal 9.95 9.66 5 163528 77 50441514
Atrioventricular block second degree 9.95 9.66 30 163503 3591 50438000
Blood magnesium abnormal 9.95 9.66 10 163523 484 50441107
Finger deformity 9.93 9.66 3 163530 5679 50435912
Peripheral paralysis 9.90 9.66 5 163528 78 50441513
Paratracheal lymphadenopathy 9.86 9.66 4 163529 36 50441555
Ischaemic skin ulcer 9.86 9.66 4 163529 36 50441555
Ventricular tachycardia 9.85 9.66 86 163447 15735 50425856
Pulmonary arterial wedge pressure increased 9.85 9.66 8 163525 292 50441299
Product expiration date issue 9.85 9.66 3 163530 10 50441581
Movement disorder 9.82 9.66 27 163506 17605 50423986
Klebsiella bacteraemia 9.81 9.66 16 163517 1261 50440330
Haemorrhagic arteriovenous malformation 9.77 9.66 6 163527 139 50441452
Neuroleptic malignant syndrome 9.74 9.66 13 163520 11117 50430474

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 279.38 10.10 475 96156 362695 29115201
Hypokalaemia 209.72 10.10 489 96142 49714 29428182
Hyperkalaemia 207.00 10.10 551 96080 60841 29417055
Drug abuse 170.78 10.10 28 96603 79855 29398041
Cardiac failure congestive 143.48 10.10 562 96069 76019 29401877
Toxicity to various agents 118.89 10.10 243 96388 173418 29304478
Toxic anterior segment syndrome 118.79 10.10 61 96570 975 29476921
Acute kidney injury 117.98 10.10 1354 95277 263913 29213983
Cardiac failure 111.71 10.10 534 96097 78753 29399143
Off label use 107.07 10.10 563 96068 300237 29177659
Oedema peripheral 104.19 10.10 636 95995 102921 29374975
Atrial fibrillation 98.30 10.10 636 95995 105010 29372886
Hypotension 73.57 10.10 963 95668 193391 29284505
Dehydration 72.75 10.10 631 96000 114117 29363779
Suicide attempt 70.57 10.10 13 96618 34097 29443799
International normalised ratio increased 67.69 10.10 306 96325 44066 29433830
Blood potassium decreased 67.53 10.10 155 96476 15579 29462317
Treatment failure 66.62 10.10 19 96612 36920 29440976
Hypervolaemia 63.68 10.10 162 96469 17383 29460513
Dyspnoea 63.55 10.10 1454 95177 325278 29152618
Asthenia 59.33 10.10 1010 95621 214240 29263656
Right ventricular failure 58.67 10.10 98 96533 7792 29470104
Fluid retention 57.81 10.10 189 96442 23371 29454525
Pulmonary arterial hypertension 50.76 10.10 89 96542 7360 29470536
Product use in unapproved indication 50.14 10.10 133 96498 86742 29391154
Rheumatoid arthritis 47.15 10.10 23 96608 32129 29445767
Therapeutic product effect incomplete 46.68 10.10 36 96595 39269 29438627
Pneumonia 46.46 10.10 1371 95260 318801 29159095
Plasma cell myeloma 45.17 10.10 240 96391 36875 29441021
Pulmonary hypertension 44.51 10.10 148 96483 18460 29459436
Anaemia 39.13 10.10 895 95736 200056 29277840
Cardiogenic shock 38.46 10.10 144 96487 19046 29458850
Gastrointestinal haemorrhage 36.94 10.10 410 96221 79123 29398773
Acute respiratory failure 35.81 10.10 176 96455 26226 29451670
Incision site pain 35.40 10.10 36 96595 1747 29476149
Foetal exposure during pregnancy 33.15 10.10 37 96594 33830 29444066
Cytokine release syndrome 31.96 10.10 105 96526 13014 29464882
Injection site pain 31.16 10.10 36 96595 32410 29445486
Oedema 30.68 10.10 232 96399 40251 29437645
Spinal muscular atrophy 30.33 10.10 16 96615 271 29477625
Blood lactic acid 30.21 10.10 17 96614 329 29477567
Fall 30.19 10.10 775 95856 176403 29301493
Arthralgia 29.33 10.10 303 96328 139314 29338582
Drug resistance 29.24 10.10 17 96614 21523 29456373
Alveolar lung disease 29.19 10.10 17 96614 352 29477544
Drug interaction 28.66 10.10 463 96168 196922 29280974
Tachypnoea 28.30 10.10 111 96520 15004 29462892
Abdominal distension 28.27 10.10 251 96380 45660 29432236
Diaphragmatic spasm 28.12 10.10 11 96620 88 29477808
Serotonin syndrome 28.09 10.10 11 96620 17501 29460395
Intentional product use issue 27.71 10.10 61 96570 42437 29435459
Toxic epidermal necrolysis 27.52 10.10 125 96506 18028 29459868
Intentional overdose 27.06 10.10 53 96578 38475 29439421
Faecal volume decreased 26.52 10.10 11 96620 104 29477792
Hypomagnesaemia 26.27 10.10 120 96511 17348 29460548
Cardiorenal syndrome 26.02 10.10 20 96611 666 29477230
Suicidal ideation 25.94 10.10 46 96585 34670 29443226
Pulmonary interstitial emphysema syndrome 25.54 10.10 17 96614 449 29477447
Ventricular tachycardia 25.46 10.10 143 96488 22431 29455465
Chronic obstructive pulmonary disease 25.26 10.10 224 96407 40731 29437165
Intentional self-injury 25.24 10.10 5 96626 12456 29465440
Aggression 24.87 10.10 49 96582 35492 29442404
Therapeutic product effect decreased 24.85 10.10 36 96595 29415 29448481
Psoriasis 24.72 10.10 42 96589 32185 29445711
Sedation 24.69 10.10 13 96618 17392 29460504
Cytomegalovirus infection 24.25 10.10 24 96607 23191 29454705
Mental status changes 24.16 10.10 196 96435 34731 29443165
Intentional product misuse 24.07 10.10 48 96583 34613 29443283
Drug dependence 22.72 10.10 21 96610 20960 29456936
Musculoskeletal stiffness 22.63 10.10 56 96575 37402 29440494
Ascites 22.43 10.10 200 96431 36419 29441477
Rectal haemorrhage 22.37 10.10 191 96440 34358 29443538
Blood loss anaemia 22.23 10.10 63 96568 7203 29470693
Drug reaction with eosinophilia and systemic symptoms 21.91 10.10 36 96595 27956 29449940
Cardiac failure chronic 21.70 10.10 58 96573 6409 29471487
Foetal disorder 21.66 10.10 19 96612 764 29477132
Diarrhoea 21.33 10.10 1308 95323 331390 29146506
Headache 21.17 10.10 421 96210 173586 29304310
Peritoneal haematoma 21.12 10.10 8 96623 58 29477838
Drug intolerance 20.99 10.10 84 96547 48295 29429601
Lower respiratory tract infection 20.82 10.10 34 96597 26468 29451428
Cardiac output decreased 20.74 10.10 19 96612 809 29477087
Sepsis 20.58 10.10 611 96020 142071 29335825
Haemoglobin decreased 20.51 10.10 481 96150 107894 29370002
Puncture site haematoma 20.28 10.10 10 96621 146 29477750
Cataract operation complication 20.28 10.10 10 96621 146 29477750
Urticaria 20.06 10.10 101 96530 54559 29423337
Product residue present 19.50 10.10 32 96599 2507 29475389
Blood creatinine increased 19.39 10.10 388 96243 84714 29393182
Appendicolith 19.22 10.10 38 96593 3442 29474454
Hypoxia 19.21 10.10 238 96393 47141 29430755
Therapeutic response decreased 19.14 10.10 32 96599 24679 29453217
Vascular purpura 18.68 10.10 23 96608 1380 29476516
Overdose 18.52 10.10 169 96462 79650 29398246
Blood urea increased 18.50 10.10 156 96475 27956 29449940
Hypoparathyroidism 18.37 10.10 14 96617 460 29477436
Ventricular fibrillation 18.32 10.10 101 96530 15732 29462164
Neutropenia neonatal 18.29 10.10 16 96615 641 29477255
Cardiomyopathy 18.24 10.10 96 96535 14691 29463205
Systemic infection 18.23 10.10 28 96603 2073 29475823
Pneumococcal sepsis 18.14 10.10 18 96613 848 29477048
Dyspnoea exertional 17.79 10.10 190 96441 36300 29441596
Skin pressure mark 17.58 10.10 7 96624 59 29477837
Sensory integrative dysfunction 17.55 10.10 6 96625 31 29477865
Obstructive airways disorder 17.54 10.10 7 96624 11009 29466887
Oropharyngeal pain 17.52 10.10 44 96587 29241 29448655
General physical health deterioration 17.50 10.10 450 96181 102407 29375489
Sopor 17.32 10.10 7 96624 10927 29466969
Respiratory tract infection bacterial 17.21 10.10 15 96616 598 29477298
Emotional disorder of childhood 17.09 10.10 6 96625 34 29477862
Acquired haemophilia 16.70 10.10 17 96614 826 29477070
Femoral artery aneurysm 16.62 10.10 9 96622 161 29477735
Constipation 16.48 10.10 489 96142 113671 29364225
Joint swelling 16.39 10.10 95 96536 49535 29428361
Therapeutic product effect prolonged 16.20 10.10 10 96621 231 29477665
Metabolic alkalosis 16.04 10.10 20 96611 1216 29476680
Cerebellar ischaemia 16.03 10.10 8 96623 120 29477776
Cardioactive drug level increased 15.73 10.10 23 96608 1630 29476266
Atelectasis 15.73 10.10 95 96536 15297 29462599
Hyponatraemia 15.62 10.10 309 96322 67324 29410572
Drug hypersensitivity 15.37 10.10 146 96485 68260 29409636
Product use issue 15.16 10.10 102 96529 51342 29426554
Increased bronchial secretion 15.05 10.10 22 96609 1559 29476337
Insomnia 15.00 10.10 202 96429 88559 29389337
Generalised oedema 14.83 10.10 74 96557 11091 29466805
Blood gases abnormal 14.70 10.10 10 96621 274 29477622
Completed suicide 14.67 10.10 207 96424 90039 29387857
Blood chloride decreased 14.48 10.10 34 96597 3467 29474429
Endophthalmitis 14.43 10.10 30 96601 2818 29475078
Sputum increased 14.41 10.10 24 96607 1903 29475993
Cellulitis 14.39 10.10 220 96411 45620 29432276
Haematoma 14.33 10.10 127 96504 23085 29454811
Dystonia 14.25 10.10 7 96624 9742 29468154
Renal tubular acidosis 14.22 10.10 23 96608 1780 29476116
Angioedema 14.11 10.10 55 96576 31860 29446036
Hepatic cirrhosis 14.03 10.10 88 96543 14356 29463540
Cor pulmonale 13.77 10.10 14 96617 679 29477217
Cardiac disorder 13.76 10.10 184 96447 37079 29440817
Pulmonary oedema 13.37 10.10 205 96426 42530 29435366
Shoshin beriberi 13.36 10.10 6 96625 70 29477826
Polyneuropathy 13.35 10.10 12 96619 12140 29465756
Substance abuse 13.18 10.10 3 96628 6784 29471112
Catheter management 13.16 10.10 15 96616 829 29477067
Red blood cell sedimentation rate increased 13.15 10.10 4 96627 7457 29470439
Hepatotoxicity 13.05 10.10 24 96607 17843 29460053
Pseudolymphoma 13.02 10.10 12 96619 515 29477381
Depressed mood 13.01 10.10 21 96610 16427 29461469
Bradycardia 12.93 10.10 293 96338 65336 29412560
Haematotoxicity 12.93 10.10 3 96628 6696 29471200
Erythema 12.79 10.10 172 96459 75434 29402462
Right atrial pressure increased 12.78 10.10 6 96625 78 29477818
Tendonitis 12.77 10.10 5 96626 7956 29469940
Red blood cells urine positive 12.73 10.10 21 96610 1652 29476244
N-terminal prohormone brain natriuretic peptide abnormal 12.73 10.10 8 96623 191 29477705
Psychotic disorder 12.63 10.10 30 96601 20324 29457572
Aspiration pleural cavity 12.55 10.10 14 96617 756 29477140
Lymphadenopathy 12.51 10.10 41 96590 25008 29452888
Respiratory distress 12.46 10.10 160 96471 31946 29445950
Injection site reaction 12.35 10.10 11 96620 11177 29466719
Wrong technique in product usage process 12.15 10.10 57 96574 31371 29446525
Gastric ischaemia 12.11 10.10 3 96628 3 29477893
Hypernatraemia 12.06 10.10 52 96579 7334 29470562
Seizure 12.01 10.10 223 96408 92900 29384996
Disease complication 11.93 10.10 25 96606 2361 29475535
Clostridium difficile colitis 11.92 10.10 79 96552 13133 29464763
Withdrawal syndrome 11.90 10.10 11 96620 10981 29466915
Limited symptom panic attack 11.90 10.10 5 96626 49 29477847
Blood albumin decreased 11.83 10.10 72 96559 11623 29466273
Swelling of eyelid 11.80 10.10 12 96619 582 29477314
Resuscitation 11.73 10.10 17 96614 1195 29476701
Mobility decreased 11.67 10.10 44 96587 25736 29452160
Renal atrophy 11.64 10.10 16 96615 1071 29476825
Mania 11.53 10.10 7 96624 8656 29469240
Bacteraemia 11.50 10.10 92 96539 16231 29461665
Infusion related reaction 11.49 10.10 90 96541 43796 29434100
Psoriatic arthropathy 11.40 10.10 19 96612 14672 29463224
Ventricular extrasystoles 11.25 10.10 66 96565 10516 29467380
Glomerular filtration rate abnormal 11.23 10.10 13 96618 731 29477165
Gout 11.21 10.10 94 96537 16817 29461079
Hypovolaemia 11.17 10.10 54 96577 7991 29469905
Body temperature decreased 11.16 10.10 11 96620 10653 29467243
Product dose omission issue 11.16 10.10 235 96396 96148 29381748
Foetal malnutrition 11.16 10.10 5 96626 58 29477838
Loss of personal independence in daily activities 11.14 10.10 44 96587 25396 29452500
Skin warm 11.12 10.10 21 96610 1839 29476057
Cortical visual impairment 11.07 10.10 4 96627 25 29477871
Blood pressure fluctuation 11.05 10.10 31 96600 19863 29458033
Hypersensitivity 11.01 10.10 115 96516 52788 29425108
Iron deficiency anaemia 10.99 10.10 58 96573 8884 29469012
Arthropathy 10.96 10.10 35 96596 21519 29456377
Drug eruption 10.93 10.10 24 96607 16717 29461179
Deep vein thrombosis 10.92 10.10 255 96376 57144 29420752
Mood swings 10.92 10.10 5 96626 7246 29470650
Diffuse alveolar damage 10.91 10.10 22 96609 2021 29475875
Pulmonary valve replacement 10.91 10.10 3 96628 6 29477890
Drug chemical incompatibility 10.91 10.10 3 96628 6 29477890
Blood bilirubin increased 10.76 10.10 163 96468 33730 29444166
Urinary tract infection 10.72 10.10 311 96320 72043 29405853
Nikolsky's sign 10.72 10.10 7 96624 179 29477717
Suprapubic pain 10.71 10.10 9 96622 341 29477555
Injection site swelling 10.71 10.10 9 96622 9408 29468488
Stoma closure 10.67 10.10 6 96625 116 29477780
Body height decreased 10.64 10.10 30 96601 3420 29474476
Haematocrit decreased 10.58 10.10 143 96488 28879 29449017
Peripheral swelling 10.58 10.10 278 96353 63461 29414435
Lactobacillus test positive 10.56 10.10 4 96627 29 29477867
Gastrointestinal vascular malformation haemorrhagic 10.56 10.10 11 96620 549 29477347
Coagulation factor VII level decreased 10.53 10.10 6 96625 119 29477777
Drug ineffective for unapproved indication 10.47 10.10 19 96612 14195 29463701
Respiratory failure 10.44 10.10 402 96229 96729 29381167
Motor neurone disease 10.43 10.10 9 96622 354 29477542
Device related infection 10.41 10.10 87 96544 15549 29462347
Inappropriate schedule of product administration 10.38 10.10 94 96537 44378 29433518
Coronavirus test positive 10.36 10.10 9 96622 357 29477539
Pericardial fibrosis 10.33 10.10 4 96627 31 29477865
Accidental exposure to product 10.25 10.10 12 96619 10741 29467155
Ischaemic cardiomyopathy 10.23 10.10 41 96590 5597 29472299
Mucosal inflammation 10.15 10.10 61 96570 31534 29446362
Product substitution issue 10.14 10.10 9 96622 9163 29468733

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 718.46 9.52 1033 210773 839214 63447712
Hyperkalaemia 496.62 9.52 1054 210752 100075 64186851
Hypokalaemia 435.90 9.52 1122 210684 120781 64166145
Cardiac failure congestive 322.73 9.52 1053 210753 129527 64157399
Acute kidney injury 291.63 9.52 2491 209315 446749 63840177
Drug abuse 262.24 9.52 57 211749 132317 64154609
Toxicity to various agents 244.36 9.52 518 211288 362995 63923931
Off label use 237.36 9.52 1171 210635 631635 63655291
Rheumatoid arthritis 229.22 9.52 127 211679 164167 64122759
Oedema peripheral 224.67 9.52 1317 210489 209000 64077926
Atrial fibrillation 220.80 9.52 1128 210678 169961 64116965
Hypervolaemia 219.81 9.52 426 211380 37859 64249067
Joint swelling 205.18 9.52 243 211563 215139 64071787
Toxic anterior segment syndrome 196.77 9.52 114 211692 2325 64284601
Hand deformity 186.46 9.52 4 211802 62767 64224159
Dehydration 184.26 9.52 1281 210525 215482 64071444
Therapeutic product effect decreased 176.17 9.52 79 211727 115272 64171654
Pulmonary hypertension 173.97 9.52 416 211390 42723 64244203
Pneumonia 167.58 9.52 2672 209134 556904 63730022
Blood potassium decreased 163.37 9.52 390 211416 40009 64246917
Pulmonary arterial hypertension 161.44 9.52 295 211511 25072 64261854
Cardiac failure 159.16 9.52 856 210950 131517 64155409
Anaemia 158.61 9.52 1920 209886 376760 63910166
Right ventricular failure 157.79 9.52 266 211540 21205 64265721
Contraindicated product administered 146.56 9.52 86 211720 107743 64179183
Arthropathy 146.19 9.52 110 211696 120857 64166069
Dyspnoea 143.85 9.52 3225 208581 715449 63571477
Fluid retention 141.14 9.52 474 211332 59132 64227794
Hypotension 138.50 9.52 1882 209924 379092 63907834
Lower respiratory tract infection 138.01 9.52 69 211737 94545 64192381
Systemic lupus erythematosus 137.25 9.52 42 211764 77570 64209356
Arthralgia 132.73 9.52 879 210927 441381 63845545
International normalised ratio increased 131.45 9.52 562 211244 78605 64208321
Drug intolerance 126.00 9.52 268 211538 187724 64099202
Gastrointestinal haemorrhage 124.99 9.52 803 211003 131509 64155417
Drug hypersensitivity 124.03 9.52 385 211421 237430 64049496
Infusion related reaction 123.65 9.52 219 211587 164248 64122678
Acute respiratory failure 122.59 9.52 402 211404 49532 64237394
Musculoskeletal stiffness 121.59 9.52 135 211671 123071 64163855
Plasma cell myeloma 115.88 9.52 374 211432 45701 64241225
Maternal exposure during pregnancy 112.28 9.52 90 211716 95794 64191132
Treatment failure 112.01 9.52 131 211675 116685 64170241
Alopecia 110.36 9.52 237 211569 165453 64121473
Therapeutic product effect incomplete 108.15 9.52 108 211698 103374 64183552
Pericarditis 103.26 9.52 38 211768 62478 64224448
Product use in unapproved indication 101.50 9.52 273 211533 176345 64110581
Hypoxia 98.52 9.52 559 211247 87590 64199336
Glossodynia 97.68 9.52 45 211761 64651 64222275
Asthenia 96.64 9.52 1956 209850 426088 63860838
Wound 94.38 9.52 68 211738 76409 64210517
Oedema 91.79 9.52 566 211240 91369 64195557
Sepsis 91.52 9.52 1157 210649 229184 64057742
Synovitis 90.89 9.52 115 211691 98975 64187951
Injection site pain 90.53 9.52 141 211665 111267 64175659
Duodenal ulcer perforation 87.22 9.52 7 211799 34618 64252308
Chronic obstructive pulmonary disease 87.07 9.52 462 211344 70586 64216340
Colitis microscopic 84.60 9.52 113 211693 7319 64279607
Diarrhoea 84.51 9.52 3030 208776 719674 63567252
Completed suicide 83.88 9.52 415 211391 223999 64062927
Helicobacter infection 83.48 9.52 13 211793 38349 64248577
Suicide attempt 79.01 9.52 70 211736 70937 64215989
Pain 77.91 9.52 1314 210492 552197 63734729
Cytokine release syndrome 77.73 9.52 195 211611 20634 64266292
Product use issue 76.66 9.52 249 211557 151466 64135460
Respiratory failure 73.81 9.52 832 210974 160351 64126575
Fall 69.54 9.52 1826 209980 415000 63871926
Hyponatraemia 68.50 9.52 767 211039 147572 64139354
Abdominal discomfort 68.21 9.52 337 211469 181985 64104941
Renal failure 68.07 9.52 903 210903 180785 64106141
Rash 67.28 9.52 1080 210726 457469 63829457
Muscle injury 64.80 9.52 6 211800 26431 64260495
Pleural effusion 64.28 9.52 667 211139 125892 64161034
Hypersensitivity 64.17 9.52 380 211426 196072 64090854
Exposure during pregnancy 61.49 9.52 100 211706 77575 64209351
Injection site swelling 60.53 9.52 30 211776 41323 64245603
Hepatic enzyme increased 59.10 9.52 223 211583 129720 64157206
Dyspnoea exertional 56.89 9.52 426 211380 73304 64213622
Irritable bowel syndrome 56.39 9.52 26 211780 37343 64249583
Nasopharyngitis 55.53 9.52 396 211410 195677 64091249
Drug resistance 55.22 9.52 23 211783 35079 64251847
Discomfort 54.39 9.52 115 211691 80763 64206163
Injection site erythema 54.33 9.52 93 211713 70707 64216219
Device expulsion 54.00 9.52 4 211802 21132 64265794
Deep vein thrombosis 53.72 9.52 555 211251 104627 64182299
Glaucoma 52.78 9.52 145 211661 16203 64270723
Intentional product use issue 51.35 9.52 152 211654 95212 64191714
Haemoglobin decreased 50.94 9.52 912 210894 194151 64092775
Intentional self-injury 50.83 9.52 16 211790 29028 64257898
Psoriasis 50.73 9.52 99 211707 71604 64215322
Suicidal ideation 50.52 9.52 88 211718 66454 64220472
Hypomagnesaemia 49.92 9.52 249 211557 37127 64249799
Injection site bruising 49.41 9.52 29 211777 36344 64250582
Folliculitis 48.47 9.52 19 211787 30058 64256868
Serotonin syndrome 48.36 9.52 35 211771 39247 64247679
Intentional overdose 47.97 9.52 144 211662 89800 64197126
Electrolyte imbalance 47.24 9.52 186 211620 25057 64261869
Ascites 47.14 9.52 357 211449 61644 64225282
Bronchitis 46.48 9.52 554 211252 108189 64178737
Cardiogenic shock 46.15 9.52 220 211586 32207 64254719
Impaired healing 45.88 9.52 80 211726 60393 64226533
Haematoma 45.67 9.52 284 211522 45966 64240960
Blood loss anaemia 44.63 9.52 123 211683 13769 64273157
Catheter management 44.45 9.52 55 211751 3300 64283626
C-reactive protein abnormal 44.16 9.52 20 211786 29027 64257899
Injection site reaction 43.99 9.52 53 211753 46611 64240315
Pulmonary oedema 43.48 9.52 422 211384 78252 64208674
Therapeutic response decreased 43.39 9.52 65 211741 52123 64234803
Psoriatic arthropathy 43.14 9.52 47 211759 43234 64243692
Atrial flutter 43.13 9.52 151 211655 19229 64267697
Incision site pain 42.61 9.52 48 211758 2606 64284320
Mental status changes 42.54 9.52 345 211461 60817 64226109
Transfusion 42.49 9.52 143 211663 17851 64269075
Cytomegalovirus infection 42.19 9.52 36 211770 37163 64249763
Pneumonia aspiration 42.13 9.52 336 211470 58935 64227991
Cor pulmonale 42.06 9.52 42 211764 1983 64284943
Blood pressure fluctuation 41.79 9.52 66 211740 51805 64235121
Urticaria 41.47 9.52 298 211508 147019 64139907
Gastrooesophageal reflux disease 41.17 9.52 436 211370 82707 64204219
Red blood cell sedimentation rate increased 40.90 9.52 26 211780 31209 64255717
Wrong technique in product usage process 40.73 9.52 96 211710 64878 64222048
Ill-defined disorder 39.48 9.52 52 211754 44000 64242926
Blood urea increased 38.04 9.52 262 211544 43891 64243035
Sleep disorder 37.60 9.52 88 211718 59621 64227305
Abdominal distension 37.55 9.52 481 211325 95513 64191413
Blood bilirubin increased 37.55 9.52 320 211486 57233 64229693
Endophthalmitis 37.48 9.52 65 211741 5300 64281626
Rectal haemorrhage 37.37 9.52 338 211468 61479 64225447
Inappropriate schedule of product administration 37.18 9.52 166 211640 92120 64194806
Abortion spontaneous 37.16 9.52 18 211788 25125 64261801
Oxygen consumption increased 36.68 9.52 59 211747 4522 64282404
Full blood count decreased 36.45 9.52 159 211647 22423 64264503
Respiratory distress 36.29 9.52 295 211511 52036 64234890
Thrombocytopenia 35.66 9.52 975 210831 222826 64064100
Pregnancy 35.62 9.52 12 211794 20853 64266073
Urinary tract infection 35.51 9.52 1004 210802 230592 64056334
Ventricular tachycardia 35.47 9.52 213 211593 34052 64252874
Cardiac failure acute 35.21 9.52 126 211680 16218 64270708
Drug eruption 35.18 9.52 40 211766 36096 64250830
Metabolic alkalosis 34.80 9.52 53 211753 3875 64283051
Syncope 34.65 9.52 718 211088 156917 64130009
Generalised oedema 34.56 9.52 148 211658 20705 64266221
Cardiorenal syndrome 33.78 9.52 30 211776 1220 64285706
Cataract operation complication 33.69 9.52 17 211789 260 64286666
Mobility decreased 33.63 9.52 156 211650 85684 64201242
Product residue present 33.44 9.52 47 211759 3195 64283731
Cardiac failure chronic 33.06 9.52 84 211722 8957 64277969
Arthritis 33.02 9.52 152 211654 83662 64203264
Metabolic encephalopathy 33.00 9.52 78 211728 7947 64278979
Swelling 32.73 9.52 352 211454 159866 64127060
Cardioactive drug level increased 32.48 9.52 48 211758 3417 64283509
Brain natriuretic peptide increased 32.27 9.52 75 211731 7558 64279368
Clostridium difficile colitis 31.96 9.52 175 211631 27048 64259878
Accidental exposure to product 31.79 9.52 24 211782 26340 64260586
Sedation 31.32 9.52 55 211751 41407 64245519
Hepatotoxicity 31.11 9.52 52 211754 39910 64247016
Hyperaldosteronism 31.03 9.52 18 211788 368 64286558
Vascular purpura 30.85 9.52 40 211766 2516 64284410
Sinusitis 30.05 9.52 320 211486 145608 64141318
Spinal muscular atrophy 29.89 9.52 16 211790 278 64286648
Injection site pruritus 29.65 9.52 49 211757 37777 64249149
Headache 29.42 9.52 1430 210376 528037 63758889
Obstructive airways disorder 29.41 9.52 20 211786 23165 64263761
Cellulitis 29.25 9.52 451 211355 93206 64193720
Blood creatinine increased 29.03 9.52 616 211190 135166 64151760
Oropharyngeal pain 28.93 9.52 172 211634 88695 64198231
Febrile neutropenia 28.89 9.52 814 210992 186843 64100083
Death 28.71 9.52 1895 209911 480810 63806116
Depressed mood 28.68 9.52 57 211749 40955 64245971
Tachypnoea 28.68 9.52 167 211639 26404 64260522
Pulmonary embolism 28.45 9.52 655 211151 145701 64141225
Toxic epidermal necrolysis 28.24 9.52 214 211592 36952 64249974
Tenosynovitis 28.18 9.52 3 211803 11830 64275096
Blood lactic acid 28.01 9.52 18 211788 445 64286481
Atelectasis 27.91 9.52 169 211637 27097 64259829
Diaphragmatic spasm 27.85 9.52 11 211795 90 64286836
Diverticulitis 26.94 9.52 218 211588 38400 64248526
Epistaxis 26.73 9.52 462 211344 97669 64189257
Cholestasis 26.43 9.52 244 211562 44628 64242298
Intentional product misuse 26.23 9.52 135 211671 72160 64214766
Cardiac arrest 26.19 9.52 677 211129 153387 64133539
Dementia 26.09 9.52 136 211670 20630 64266296
Malnutrition 25.95 9.52 128 211678 18997 64267929
Infection 25.85 9.52 439 211367 184441 64102485
Electrocardiogram U wave present 25.84 9.52 11 211795 111 64286815
Alveolar lung disease 25.58 9.52 18 211788 519 64286407
Hypernatraemia 25.44 9.52 93 211713 12096 64274830
Encephalopathy 25.27 9.52 300 211506 58519 64228407
Blister 25.16 9.52 159 211647 80808 64206118
Hyperkaliuria 25.04 9.52 12 211794 163 64286763
Loss of personal independence in daily activities 24.78 9.52 138 211668 72316 64214610
Septic shock 24.74 9.52 485 211321 104952 64181974
Drug ineffective for unapproved indication 24.71 9.52 40 211766 31093 64255833
Calcium deficiency 24.64 9.52 20 211786 718 64286208
Anaphylactic reaction 24.47 9.52 129 211677 68535 64218391
Joint stiffness 24.19 9.52 39 211767 30365 64256561
Rheumatoid nodule 23.94 9.52 6 211800 12645 64274281
Blood pressure increased 23.39 9.52 412 211394 172140 64114786
Gout 23.38 9.52 135 211671 21278 64265648
Alkalosis hypochloraemic 23.27 9.52 16 211790 444 64286482
Bradycardia 23.26 9.52 530 211276 117689 64169237
Cerebrovascular accident 23.22 9.52 604 211202 136979 64149947
Pulmonary interstitial emphysema syndrome 23.18 9.52 16 211790 447 64286479
Arrhythmia 23.17 9.52 271 211535 52673 64234253
Faecal volume decreased 23.11 9.52 11 211795 147 64286779
Cardiomegaly 23.11 9.52 145 211661 23539 64263387
Device related infection 23.08 9.52 176 211630 30450 64256476
Blood pressure systolic increased 23.04 9.52 84 211722 49369 64237557
Hospice care 23.01 9.52 66 211740 7559 64279367
Immune effector cell-associated neurotoxicity syndrome 22.97 9.52 35 211771 2560 64284366
Chronic respiratory failure 22.86 9.52 35 211771 2571 64284355
Left ventricular failure 22.69 9.52 70 211736 8347 64278579
Acute motor-sensory axonal neuropathy 22.44 9.52 15 211791 397 64286529
Skin pressure mark 22.44 9.52 9 211797 77 64286849
Puncture site haematoma 22.29 9.52 11 211795 160 64286766
Blood magnesium decreased 21.75 9.52 97 211709 13808 64273118
Dystonia 21.71 9.52 18 211788 18847 64268079
Insomnia 21.52 9.52 490 211316 197346 64089580
Drug interaction 21.45 9.52 971 210835 361112 63925814
Gastrointestinal disorder 21.29 9.52 190 211616 89519 64197407
Urine chloride decreased 21.21 9.52 9 211797 90 64286836
Subileus 21.15 9.52 49 211757 4928 64281998
Blood potassium increased 21.11 9.52 152 211654 25828 64261098
Stomatitis 21.11 9.52 244 211562 109361 64177565
Impaired work ability 20.86 9.52 12 211794 15207 64271719
Disease progression 20.81 9.52 611 211195 141069 64145857
Ventricular fibrillation 20.80 9.52 142 211664 23718 64263208
Mania 20.72 9.52 14 211792 16272 64270654
Cardiac disorder 20.70 9.52 277 211529 55539 64231387
Blood potassium abnormal 20.61 9.52 33 211773 2519 64284407
Aggression 20.58 9.52 80 211726 46152 64240774
Subdural haematoma 20.46 9.52 160 211646 27894 64259032
Inflammation 20.41 9.52 128 211678 65172 64221754
Prothrombin time prolonged 20.40 9.52 104 211702 15637 64271289
Chest pain 20.18 9.52 958 210848 235022 64051904
Sopor 20.08 9.52 42 211764 29619 64257307
Melaena 19.96 9.52 266 211540 53282 64233644
Body temperature decreased 19.94 9.52 34 211772 25894 64261032
Right atrial pressure increased 19.91 9.52 12 211794 264 64286662
Schizophrenia 19.82 9.52 6 211800 11162 64275764
Transplant evaluation 19.79 9.52 25 211781 1532 64285394
Unevaluable event 19.74 9.52 253 211553 50236 64236690
Drug-induced liver injury 19.61 9.52 85 211721 47558 64239368
Constipation 19.60 9.52 931 210875 228406 64058520
Blood albumin decreased 19.32 9.52 127 211679 20946 64265980
Appendicolith 19.17 9.52 38 211768 3431 64283495
Asthma 19.12 9.52 210 211596 95015 64191911
Ileus 19.03 9.52 135 211671 22831 64264095
Overdose 18.86 9.52 390 211416 159176 64127750
Osteoarthritis 18.85 9.52 126 211680 63210 64223716
Lower gastrointestinal haemorrhage 18.71 9.52 93 211713 13846 64273080
Hypocalcaemia 18.39 9.52 214 211592 41539 64245387
Substance abuse 18.39 9.52 4 211802 9288 64277638
Hip arthroplasty 18.33 9.52 26 211780 21325 64265601
Pickwickian syndrome 18.32 9.52 13 211793 380 64286546
Live birth 18.18 9.52 7 211799 11197 64275729
Femoral artery aneurysm 18.17 9.52 10 211796 184 64286742
Haematocrit decreased 18.15 9.52 266 211540 54389 64232537
Failure to thrive 18.14 9.52 75 211731 10329 64276597
Neuroleptic malignant syndrome 18.12 9.52 34 211772 24962 64261964
Tendonitis 18.11 9.52 24 211782 20258 64266668
Lung infiltration 18.02 9.52 124 211682 20765 64266161
Pulmonary arterial pressure increased 18.01 9.52 41 211765 4075 64282851
Arteriovenous malformation 18.00 9.52 24 211782 1552 64285374
Catheter site infection 17.89 9.52 50 211756 5643 64281283
Pancytopenia 17.88 9.52 606 211200 142703 64144223
Depressed level of consciousness 17.82 9.52 176 211630 81260 64205666
Bacteraemia 17.74 9.52 150 211656 26761 64260165
Confusion postoperative 17.61 9.52 10 211796 196 64286730
Haemoptysis 17.61 9.52 242 211564 48806 64238120
Blood chloride decreased 17.56 9.52 59 211747 7357 64279569
Poisoning 17.47 9.52 28 211778 21851 64265075
Herpes zoster 17.38 9.52 171 211635 79016 64207910
Mood swings 17.37 9.52 19 211787 17449 64269477
Urine sodium decreased 17.37 9.52 11 211795 265 64286661
Peritonitis bacterial 17.22 9.52 67 211739 8976 64277950
Acute left ventricular failure 17.20 9.52 22 211784 1365 64285561
Hypovolaemia 17.15 9.52 98 211708 15388 64271538
Therapeutic response shortened 17.10 9.52 6 211800 10164 64276762
Head injury 17.09 9.52 174 211632 32668 64254258
Acne 17.08 9.52 31 211775 23050 64263876
Respiratory tract infection bacterial 16.97 9.52 17 211789 806 64286120
Injection site rash 16.93 9.52 16 211790 15726 64271200
Knee arthroplasty 16.83 9.52 40 211766 26959 64259967
Blood cholesterol increased 16.77 9.52 96 211710 49970 64236956
Increased bronchial secretion 16.76 9.52 32 211774 2810 64284116
Electrocardiogram abnormal 16.73 9.52 88 211718 13393 64273533
Pneumococcal sepsis 16.67 9.52 21 211785 1283 64285643
Purging 16.64 9.52 6 211800 37 64286889
Haematotoxicity 16.52 9.52 11 211795 12885 64274041
Chronic left ventricular failure 16.51 9.52 16 211790 728 64286198
Grip strength decreased 16.42 9.52 9 211797 11715 64275211
Polyneuropathy 16.32 9.52 25 211781 19869 64267057
Device issue 16.25 9.52 31 211775 22617 64264309
Prothrombin consumption time prolonged 16.24 9.52 6 211800 40 64286886
Product storage error 16.22 9.52 12 211794 13306 64273620
Lymphoedema 16.18 9.52 70 211736 9835 64277091
Transplant rejection 16.15 9.52 20 211786 17381 64269545
Platelet count decreased 16.11 9.52 689 211117 167022 64119904
Product substitution issue 16.09 9.52 21 211785 17840 64269086
Blood alkaline phosphatase increased 16.06 9.52 267 211539 56012 64230914
Iron deficiency anaemia 16.05 9.52 125 211681 21764 64265162
Paranoia 16.03 9.52 18 211788 16334 64270592
Psychotic disorder 15.93 9.52 59 211747 34519 64252407
Muscle spasticity 15.64 9.52 19 211787 16650 64270276
Throat tightness 15.51 9.52 33 211773 23127 64263799
Small intestinal obstruction 15.33 9.52 131 211675 23442 64263484
Injection site warmth 15.30 9.52 13 211793 13449 64273477
Aspiration pleural cavity 15.09 9.52 21 211785 1414 64285512
Alkalosis 15.07 9.52 12 211794 419 64286507
Movement disorder 15.02 9.52 31 211775 21969 64264957
Pain in jaw 15.00 9.52 202 211604 40553 64246373
Enterococcus test positive 15.00 9.52 23 211783 1692 64285234
Ischaemic cardiomyopathy 14.97 9.52 53 211753 6785 64280141
Blood parathyroid hormone decreased 14.93 9.52 3 211803 7363 64279563
Electrocardiogram T wave peaked 14.84 9.52 16 211790 827 64286099
Disability 14.78 9.52 11 211795 12161 64274765
Hypercapnia 14.64 9.52 57 211749 7637 64279289
Catheterisation cardiac 14.53 9.52 42 211764 4831 64282095
Right ventricular dysfunction 14.50 9.52 26 211780 2177 64284749
Colitis 14.47 9.52 272 211534 58402 64228524
Torsade de pointes 14.35 9.52 102 211704 17261 64269665
Throat irritation 14.31 9.52 57 211749 32654 64254272
Pulmonary arterial wedge pressure increased 14.29 9.52 12 211794 452 64286474
Foot deformity 14.26 9.52 20 211786 16484 64270442
Blood pressure diastolic abnormal 14.18 9.52 11 211795 11906 64275020
Pneumonia staphylococcal 14.14 9.52 39 211767 4367 64282559
Drug reaction with eosinophilia and systemic symptoms 14.14 9.52 112 211694 54105 64232821
Paracentesis 14.11 9.52 19 211787 1240 64285686
Mental status changes postoperative 14.04 9.52 8 211798 158 64286768
Dyskinesia 14.03 9.52 74 211732 39314 64247612
Thrombosis 13.98 9.52 317 211489 70325 64216601
White blood cell count decreased 13.96 9.52 643 211163 157194 64129732
International normalised ratio decreased 13.91 9.52 55 211751 7423 64279503
Asphyxia 13.91 9.52 7 211799 9559 64277367
Post transplant lymphoproliferative disorder 13.85 9.52 7 211799 9537 64277389
Cardiac amyloidosis 13.84 9.52 20 211786 1395 64285531
Pericardial effusion 13.81 9.52 193 211613 39061 64247865
Decubitus ulcer 13.74 9.52 83 211723 13296 64273630
Oesophageal pain 13.73 9.52 32 211774 3231 64283695
Drug chemical incompatibility 13.72 9.52 6 211800 65 64286861
Cardiac output decreased 13.72 9.52 22 211784 1682 64285244
Cardiovascular insufficiency 13.62 9.52 28 211778 2596 64284330
Peritoneal haematoma 13.60 9.52 8 211798 168 64286758
Cardioversion 13.38 9.52 23 211783 1862 64285064
Shoshin beriberi 13.33 9.52 6 211800 70 64286856
Influenza like illness 13.22 9.52 134 211672 61568 64225358
Heparin-induced thrombocytopenia 13.15 9.52 59 211747 8420 64278506
Blood pressure diastolic decreased 13.15 9.52 34 211772 22267 64264659
Hypochloraemia 13.15 9.52 24 211782 2037 64284889
Supraventricular extrasystoles 13.08 9.52 46 211760 5869 64281057
Epstein-Barr virus infection 13.08 9.52 13 211793 12475 64274451
Pantoea agglomerans infection 13.03 9.52 6 211800 74 64286852
Cardiomyopathy 13.03 9.52 134 211672 25222 64261704
Cor pulmonale chronic 12.93 9.52 9 211797 255 64286671
Seizure 12.82 9.52 434 211372 166458 64120468
Middle insomnia 12.81 9.52 14 211792 12863 64274063
Supraventricular tachycardia 12.79 9.52 106 211700 18801 64268125
Blood pressure diastolic increased 12.69 9.52 10 211796 10742 64276184
Erythema 12.67 9.52 494 211312 186576 64100350
Mitral valve incompetence 12.67 9.52 134 211672 25404 64261522
Hepatic cirrhosis 12.59 9.52 137 211669 26161 64260765
Food allergy 12.58 9.52 5 211801 7846 64279080
Irritability 12.56 9.52 70 211736 36676 64250250
Catheter culture positive 12.55 9.52 8 211798 195 64286731
Spinal cord paralysis 12.52 9.52 7 211799 133 64286793
Hypertransaminasaemia 12.51 9.52 4 211802 7187 64279739
Nodule 12.50 9.52 25 211781 17922 64269004
Coagulation factor VII level decreased 12.33 9.52 8 211798 201 64286725
Occult blood positive 12.31 9.52 47 211759 6240 64280686
Orthopnoea 12.30 9.52 61 211745 9073 64277853
Anterior chamber disorder 12.29 9.52 7 211799 138 64286788
Paraesthesia 12.25 9.52 342 211464 134180 64152746
Altered visual depth perception 12.20 9.52 10 211796 364 64286562
Multiple organ dysfunction syndrome 12.18 9.52 427 211379 100986 64185940
Activated partial thromboplastin time prolonged 12.17 9.52 78 211728 12753 64274173
Respiratory depression 12.16 9.52 38 211768 23405 64263521
Oral herpes 12.14 9.52 35 211771 22117 64264809
Injection site haemorrhage 12.14 9.52 40 211766 24238 64262688
HLA-B*27 positive 12.11 9.52 6 211800 88 64286838
Right ventricular dilatation 12.10 9.52 19 211787 1426 64285500
Gastric ischaemia 12.10 9.52 3 211803 3 64286923
Deposit eye 12.06 9.52 5 211801 47 64286879
Skin dystrophy 12.06 9.52 5 211801 47 64286879
Oesophageal spasm 12.01 9.52 26 211780 2499 64284427
Osteonecrosis of jaw 11.97 9.52 79 211727 39746 64247180
N-terminal prohormone brain natriuretic peptide increased 11.92 9.52 32 211774 3527 64283399
Limited symptom panic attack 11.87 9.52 5 211801 49 64286877
Nail dystrophy 11.87 9.52 14 211792 799 64286127
Congestive cardiomyopathy 11.81 9.52 66 211740 10278 64276648
Joint range of motion decreased 11.79 9.52 29 211777 19314 64267612
Device difficult to use 11.71 9.52 9 211797 9789 64277137
Familial periodic paralysis 11.69 9.52 7 211799 152 64286774
Hepatocellular injury 11.61 9.52 211 211595 45024 64241902
Withdrawal syndrome 11.55 9.52 39 211767 23453 64263473
Pseudomonal bacteraemia 11.52 9.52 24 211782 2245 64284681
Cortical visual impairment 11.47 9.52 4 211802 22 64286904
Osmotic demyelination syndrome 11.46 9.52 17 211789 1214 64285712
Renal atrophy 11.42 9.52 20 211786 1644 64285282
Extrapyramidal disorder 11.38 9.52 30 211776 19522 64267404
Liver injury 11.36 9.52 55 211751 29877 64257049
Injection site urticaria 11.30 9.52 12 211794 11169 64275757
Shock haemorrhagic 11.29 9.52 94 211712 16697 64270229
Arrhythmia supraventricular 11.26 9.52 21 211785 1812 64285114
Renal tubular acidosis 11.23 9.52 28 211778 2951 64283975
International normalised ratio abnormal 11.21 9.52 39 211767 4949 64281977
Blood albumin abnormal 11.20 9.52 12 211794 616 64286310
Cerebral haematoma 11.15 9.52 50 211756 7135 64279791
Enterococcal sepsis 11.09 9.52 25 211781 2469 64284457
Psychomotor hyperactivity 11.07 9.52 19 211787 14432 64272494
Post procedural complication 11.05 9.52 113 211693 21240 64265686
Cardioactive drug level decreased 11.04 9.52 7 211799 169 64286757
Mucosal inflammation 11.03 9.52 142 211664 62442 64224484
Acute pulmonary oedema 11.02 9.52 76 211730 12733 64274193
Skin disorder 11.02 9.52 50 211756 27630 64259296
Right ventricular systolic pressure increased 11.01 9.52 14 211792 864 64286062
Ovarian cyst 10.94 9.52 12 211794 11006 64275920
Thrombotic microangiopathy 10.93 9.52 24 211782 16631 64270295
Renin decreased 10.92 9.52 6 211800 110 64286816
N-terminal prohormone brain natriuretic peptide abnormal 10.92 9.52 8 211798 246 64286680
Nightmare 10.91 9.52 34 211772 20959 64265967
Tonsillar haemorrhage 10.89 9.52 8 211798 247 64286679
Abortion incomplete complicated 10.89 9.52 3 211803 6 64286920
Neuropathy peripheral 10.87 9.52 481 211325 117044 64169882
Hypoalbuminaemia 10.86 9.52 97 211709 17577 64269349
Cognitive disorder 10.85 9.52 122 211684 54965 64231961
Panniculitis 10.81 9.52 8 211798 8871 64278055
Pruritus 10.80 9.52 881 210925 311519 63975407
Resuscitation 10.78 9.52 22 211784 2029 64284897
Hepatitis B 10.77 9.52 6 211800 7739 64279187
Ageusia 10.75 9.52 80 211726 13733 64273193
Frequent bowel movements 10.72 9.52 28 211778 18277 64268649
Product selection error 10.72 9.52 7 211799 178 64286748
Pupillary block 10.66 9.52 4 211802 28 64286898
Blood phosphorus decreased 10.64 9.52 42 211764 5663 64281263
Dry eye 10.63 9.52 54 211752 28965 64257961
Uterine perforation 10.56 9.52 3 211803 5817 64281109
Tracheal obstruction 10.51 9.52 7 211799 184 64286742
Pharyngitis 10.50 9.52 30 211776 19009 64267917
Acute hepatic failure 10.49 9.52 47 211759 26065 64260861
Decreased appetite 10.48 9.52 1066 210740 280223 64006703
Premature delivery 10.46 9.52 29 211777 18560 64268366
Anhedonia 10.46 9.52 79 211727 13627 64273299
Mouth ulceration 10.45 9.52 63 211743 32381 64254545
Catheter placement 10.44 9.52 25 211781 2568 64284358
Electrocardiogram T wave amplitude decreased 10.43 9.52 11 211795 554 64286372
Lung perforation 10.43 9.52 5 211801 68 64286858
Lactobacillus test positive 10.43 9.52 4 211802 30 64286896
Abortion induced 10.35 9.52 4 211802 6384 64280542
Vascular encephalopathy 10.32 9.52 11 211795 561 64286365
Suspected suicide 10.28 9.52 8 211798 8646 64278280
Hyperthyroidism 10.28 9.52 98 211708 18081 64268845
Leukoencephalopathy 10.28 9.52 5 211801 6962 64279964
Sleep apnoea syndrome 10.22 9.52 146 211660 29686 64257240
Flail chest 10.18 9.52 5 211801 72 64286854
Pulse absent 10.16 9.52 57 211749 8889 64278037
Catheter site extravasation 10.15 9.52 9 211797 365 64286561
Blood glucose increased 10.11 9.52 406 211400 97667 64189259
Gallbladder rupture 10.11 9.52 13 211793 811 64286115
Carbon dioxide increased 10.06 9.52 21 211785 1968 64284958
Renal tubular necrosis 10.04 9.52 114 211692 21996 64264930
Stoma closure 9.99 9.52 6 211800 131 64286795
Catheter site scab 9.97 9.52 7 211799 201 64286725
Aspartate aminotransferase increased 9.95 9.52 485 211321 119303 64167623
Hepatic function abnormal 9.88 9.52 150 211656 64163 64222763
Heart transplant 9.86 9.52 16 211790 1235 64285691
Body height decreased 9.85 9.52 50 211756 7504 64279422
Thyroid disorder 9.84 9.52 69 211737 11623 64275303
Multiple sclerosis relapse 9.81 9.52 87 211719 41048 64245878
Poor venous access 9.81 9.52 16 211790 12401 64274525
Musculoskeletal pain 9.80 9.52 198 211608 81096 64205830
Glomerular filtration rate abnormal 9.79 9.52 16 211790 1243 64285683
Blood gases abnormal 9.77 9.52 14 211792 969 64285957
Congestive hepatopathy 9.76 9.52 32 211774 3941 64282985
Photosensitivity reaction 9.75 9.52 29 211777 18144 64268782
Clostridium difficile infection 9.75 9.52 170 211636 35993 64250933
Adenocarcinoma pancreas 9.73 9.52 20 211786 1853 64285073
Bezoar 9.70 9.52 22 211784 2181 64284745
Chronic kidney disease 9.68 9.52 254 211552 57665 64229261
Blood aldosterone increased 9.68 9.52 7 211799 211 64286715
Device related sepsis 9.66 9.52 38 211768 5117 64281809
Aortic stenosis 9.66 9.52 44 211762 6321 64280605
Paradoxical drug reaction 9.64 9.52 4 211802 6116 64280810
Generalised tonic-clonic seizure 9.64 9.52 84 211722 39773 64247153
Vasculitis 9.62 9.52 29 211777 18066 64268860
Night sweats 9.61 9.52 74 211732 35972 64250954
Atrioventricular block 9.59 9.52 70 211736 11945 64274981
Vascular device infection 9.58 9.52 43 211763 6137 64280789
Endometrial disorder 9.53 9.52 10 211796 501 64286425

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A12BA01 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
POTASSIUM
Potassium
ATC A12BA51 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
POTASSIUM
Potassium
ATC B05XA01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
CHEBI has role CHEBI:33287 fertilizers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Hypokalemia indication 43339004
Incomplete passage of stool indication 249515001
Hypokalemia Prevention indication
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Urinary tract obstruction contraindication 7163005 DOID:5200
Poisoning by digitalis glycoside contraindication 12876009
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Primary hyperoxaluria contraindication 17901006 DOID:2977
Myocardial infarction contraindication 22298006 DOID:5844
Acute vomiting contraindication 23971007
Ventricular tachycardia contraindication 25569003
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Acute epiglottitis contraindication 29608009 DOID:9398
Sarcoidosis contraindication 31541009 DOID:11335
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Toxic colitis contraindication 42359007
Achalasia of esophagus contraindication 45564002 DOID:9164
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Gastrointestinal perforation contraindication 51875005
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Perforation of intestine contraindication 56905009 DOID:2074
Peptic reflux disease contraindication 57643001
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Ulcerative colitis contraindication 64766004 DOID:8577
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Hypercalcemia contraindication 66931009 DOID:12678
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Incontinence of feces contraindication 72042002
Arteriosclerotic vascular disease contraindication 72092001
Appendicitis contraindication 74400008 DOID:8337
Hyperchloremia contraindication 74450001
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Third degree burn injury contraindication 80247002
Intestinal obstruction contraindication 81060008 DOID:8437
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Hiatal hernia contraindication 84089009 DOID:12642
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Myocardial dysfunction contraindication 233928007
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
At risk for aspiration contraindication 371736008
Primary adrenocortical insufficiency contraindication 373662000
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastric ulcer contraindication 397825006 DOID:10808
Hemochromatosis contraindication 399187006 DOID:2352
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Unconscious contraindication 418107008
Hypertensive urgency contraindication 443482000
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Esophageal Compression contraindication
Predisposition to Nausea and Vomiting contraindication
Suppression of the Gag Reflex contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
5MG,N/A;N/A,210GM;N/A,0.74GM;N/A,2.86GM;N/A,5.6GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** HALFLYTELY BRAINTREE N021551 July 16, 2010 DISCN FOR SOLUTION, TABLET, DELAYED RELEASE ORAL 7291324 Oct. 22, 2022 GASTROINTESTINAL LAVAGE INDICATED FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10792306 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9592252 Aug. 11, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10918723 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9326969 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
0.225GM;0.188GM;1.479GM SUTAB BRAINTREE LABS N213135 Nov. 10, 2020 RX TABLET ORAL 11033498 Aug. 4, 2037 GASTROINTESTINAL TABLETS INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3.68GM/1000ML;3.05GM/1000ML;0.314GM/1000ML ;3.09GM/1000ML;6.34GM/1000ML;0.187GM/1000ML (5000ML) PHOXILLUM BK 4/2.5 IN PLASTIC CONTAINER BAXTER HLTHCARE CORP N207026 Jan. 13, 2015 RX INJECTABLE INJECTION Jan. 13, 2022 AS A REPLACEMENT SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) AND IN CASE OF DRUG POISONING WHEN CRRT IS USED TO REMOVE DIALYZABLE SUBSTANCES
N/A/1000ML;3.05GM/1000ML;0.314GM/1000ML;2.21GM/1000ML;6.95GM/1000ML;0.187GM/1000ML (5000ML) PHOXILLUM B22K 4/0 IN PLASTIC CONTAINER BAXTER HLTHCARE CORP N207026 Jan. 13, 2015 RX INJECTABLE INJECTION Jan. 13, 2022 AS A REPLACEMENT SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) AND IN CASE OF DRUG POISONING WHEN CRRT IS USED TO REMOVE DIALYZABLE SUBSTANCES
0.225GM;0.188GM;1.479GM SUTAB BRAINTREE LABS N213135 Nov. 10, 2020 RX TABLET ORAL Nov. 10, 2023 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 4 Enzyme Ki 4.05 CHEMBL

External reference:

IDSource
4020361 VUID
N0000148186 NUI
D02060 KEGG_DRUG
4017447 VANDF
4020073 VANDF
4020361 VANDF
C0032825 UMLSCUI
CHEBI:32588 CHEBI
CHEMBL1200731 ChEMBL_ID
D011189 MESH_DESCRIPTOR_UI
DB00761 DRUGBANK_ID
660YQ98I10 UNII
4873 PUBCHEM_CID
8591 RXNORM
5326 MMSL
7330 MMSL
d00345 MMSL
000767 NDDF
007231 NDDF
420155008 SNOMEDCT_US
8631001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-1795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3023 TABLET, FILM COATED, EXTENDED RELEASE 1500 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3058 TABLET, FILM COATED, EXTENDED RELEASE 600 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3278 TABLET, FILM COATED, EXTENDED RELEASE 750 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-7804 TABLET, FILM COATED, EXTENDED RELEASE 750 mg ORAL NDA 24 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0466 SOLUTION 3 g ORAL UNAPPROVED DRUG OTHER 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0841 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0841 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-1680 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-1680 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-2520 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-2520 SOLUTION 40 meq ORAL ANDA 21 sections
KLOR-CON HUMAN PRESCRIPTION DRUG LABEL 1 0245-0360 POWDER, FOR SOLUTION 1.50 g ORAL ANDA 21 sections
KLOR-CON HUMAN PRESCRIPTION DRUG LABEL 1 0245-5315 TABLET, FILM COATED, EXTENDED RELEASE 600 mg ORAL NDA 25 sections
KLOR-CON HUMAN PRESCRIPTION DRUG LABEL 1 0245-5316 TABLET, FILM COATED, EXTENDED RELEASE 750 mg ORAL NDA 25 sections
KLOR-CON M HUMAN PRESCRIPTION DRUG LABEL 1 0245-5317 TABLET, EXTENDED RELEASE 750 mg ORAL ANDA 21 sections
KLOR-CON M HUMAN PRESCRIPTION DRUG LABEL 1 0245-5318 TABLET, EXTENDED RELEASE 1125 mg ORAL ANDA 21 sections
KLOR-CON M HUMAN PRESCRIPTION DRUG LABEL 1 0245-5319 TABLET, EXTENDED RELEASE 1500 mg ORAL ANDA 21 sections
Klor-Con Sprinkle HUMAN PRESCRIPTION DRUG LABEL 1 0245-5320 CAPSULE, EXTENDED RELEASE 600 mg ORAL ANDA 22 sections
Klor-Con Sprinkle HUMAN PRESCRIPTION DRUG LABEL 1 0245-5321 CAPSULE, EXTENDED RELEASE 750 mg ORAL ANDA 22 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 0.15 g INTRAVENOUS NDA 24 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 0.15 g INTRAVENOUS NDA 24 sections
POTASSIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0264-1940 INJECTION, SOLUTION, CONCENTRATE 14.90 g PARENTERAL ANDA 15 sections
POTASSIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0264-1940 INJECTION, SOLUTION, CONCENTRATE 14.90 g PARENTERAL ANDA 15 sections
POTASSIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0264-1944 INJECTION, SOLUTION, CONCENTRATE 14.90 g PARENTERAL ANDA 15 sections
POTASSIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0264-1944 INJECTION, SOLUTION, CONCENTRATE 14.90 g PARENTERAL ANDA 15 sections
Balanced Salt HUMAN PRESCRIPTION DRUG LABEL 6 0264-1945 SOLUTION 0.75 mg IRRIGATION ANDA 11 sections
Ringers HUMAN PRESCRIPTION DRUG LABEL 3 0264-2202 IRRIGANT 0.03 g IRRIGATION NDA 22 sections