deoxycholic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4988 83-44-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • choleic acid
  • deoxycholate
  • sodium deoxycholate
  • deoxycholic acid
  • kybella
  • ATX-101
  • dihydroxycholanoic acid
  • desoxycholic acid
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
  • Molecular weight: 392.58
  • Formula: C24H40O4
  • CLOGP: 4.51
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 77.76
  • ALOGS: -4.35
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 29, 2015 FDA KYTHERA BIOPHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site swelling 195.45 92.73 57 768 40270 46644967
Facial paresis 178.24 92.73 33 792 3135 46682102
Swelling 135.91 92.73 58 767 124453 46560784
Injection site nodule 132.52 92.73 26 799 3345 46681892
Nerve injury 111.10 92.73 26 799 7679 46677558
Injection site pain 110.38 92.73 48 777 107104 46578133

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC D11AX24 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
FDA PE N0000008476 Decreased Cell Membrane Integrity
MeSH PA D002756 Cholagogues and Choleretics
MeSH PA D005765 Gastrointestinal Agents
FDA EPC N0000191548 Cytolytic Agent
CHEBI has role CHEBI:77746 h. sapiens metabolites
CHEBI has role CHEBI:85234 human blood serum metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Excess subcutaneous fat indication 248302001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.92 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
fMet-Leu-Phe receptor GPCR ANTAGONIST Ki 4 IUPHAR
G-protein coupled bile acid receptor 1 GPCR AGONIST EC50 6.20 IUPHAR
Cell membrane Cell membrane OTHER DRUG LABEL DRUG LABEL
Steroid Delta-isomerase Unclassified Kd 4.80 CHEMBL

External reference:

IDSource
4018928 VANDF
4035848 VANDF
C4305918 UMLSCUI
CHEBI:23614 CHEBI
DHO PDB_CHEM_ID
DXC PDB_CHEM_ID
CHEMBL406393 ChEMBL_ID
CHEMBL514674 ChEMBL_ID
CHEMBL1208257 ChEMBL_ID
CHEMBL453873 ChEMBL_ID
DB05780 DRUGBANK_ID
DB03619 DRUGBANK_ID
D003840 MESH_DESCRIPTOR_UI
222528 PUBCHEM_CID
610 IUPHAR_LIGAND_ID
9540 INN_ID
005990WHZZ UNII
1367220 RXNORM
14975 MMSL
234529 MMSL
d08364 MMSL
001205 NDDF
010267 NDDF
781373006 SNOMEDCT_US
78258003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
KYBELLA HUMAN PRESCRIPTION DRUG LABEL 1 61168-101 INJECTION, SOLUTION 20 mg SUBCUTANEOUS NDA 27 sections