Stem definition | Drug id | CAS RN |
---|---|---|
4988 | 83-44-3 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
April 29, 2015 | FDA | KYTHERA BIOPHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Injection site swelling | 195.45 | 92.73 | 57 | 768 | 40270 | 46644967 |
Facial paresis | 178.24 | 92.73 | 33 | 792 | 3135 | 46682102 |
Swelling | 135.91 | 92.73 | 58 | 767 | 124453 | 46560784 |
Injection site nodule | 132.52 | 92.73 | 26 | 799 | 3345 | 46681892 |
Nerve injury | 111.10 | 92.73 | 26 | 799 | 7679 | 46677558 |
Injection site pain | 110.38 | 92.73 | 48 | 777 | 107104 | 46578133 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|
Source | Code | Description |
---|---|---|
ATC | D11AX24 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
FDA PE | N0000008476 | Decreased Cell Membrane Integrity |
MeSH PA | D002756 | Cholagogues and Choleretics |
MeSH PA | D005765 | Gastrointestinal Agents |
FDA EPC | N0000191548 | Cytolytic Agent |
CHEBI has role | CHEBI:77746 | h. sapiens metabolites |
CHEBI has role | CHEBI:85234 | human blood serum metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Excess subcutaneous fat | indication | 248302001 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.92 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
fMet-Leu-Phe receptor | GPCR | ANTAGONIST | Ki | 4 | IUPHAR | ||||
G-protein coupled bile acid receptor 1 | GPCR | AGONIST | EC50 | 6.20 | IUPHAR | ||||
Cell membrane | Cell membrane | OTHER | DRUG LABEL | DRUG LABEL | |||||
Steroid Delta-isomerase | Unclassified | Kd | 4.80 | CHEMBL |
ID | Source |
---|---|
4018928 | VANDF |
4035848 | VANDF |
C4305918 | UMLSCUI |
CHEBI:23614 | CHEBI |
DHO | PDB_CHEM_ID |
DXC | PDB_CHEM_ID |
CHEMBL406393 | ChEMBL_ID |
CHEMBL514674 | ChEMBL_ID |
CHEMBL1208257 | ChEMBL_ID |
CHEMBL453873 | ChEMBL_ID |
DB05780 | DRUGBANK_ID |
DB03619 | DRUGBANK_ID |
D003840 | MESH_DESCRIPTOR_UI |
222528 | PUBCHEM_CID |
610 | IUPHAR_LIGAND_ID |
9540 | INN_ID |
005990WHZZ | UNII |
1367220 | RXNORM |
14975 | MMSL |
234529 | MMSL |
d08364 | MMSL |
001205 | NDDF |
010267 | NDDF |
781373006 | SNOMEDCT_US |
78258003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
KYBELLA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61168-101 | INJECTION, SOLUTION | 20 mg | SUBCUTANEOUS | NDA | 27 sections |