deoxycholic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4988	83-44-3

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: choleic acid deoxycholate sodium deoxycholate deoxycholic acid kybella ATX-101 dihydroxycholanoic acid desoxycholic acid

A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent. Molecular weight: 392.58 Formula: C24H40O4 CLOGP: 4.51 LIPINSKI: 0 HAC: 4 HDO: 3 TPSA: 77.76 ALOGS: -4.35 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
April 29, 2015	FDA	KYTHERA BIOPHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Injection site swelling	195.45	92.73	57	768	40270	46644967
Facial paresis	178.24	92.73	33	792	3135	46682102
Swelling	135.91	92.73	58	767	124453	46560784
Injection site nodule	132.52	92.73	26	799	3345	46681892
Nerve injury	111.10	92.73	26	799	7679	46677558
Injection site pain	110.38	92.73	48	777	107104	46578133

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event

Pharmacologic Action:

Source	Code	Description
ATC	D11AX24	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
FDA PE	N0000008476	Decreased Cell Membrane Integrity
MeSH PA	D002756	Cholagogues and Choleretics
MeSH PA	D005765	Gastrointestinal Agents
FDA EPC	N0000191548	Cytolytic Agent
CHEBI has role	CHEBI:77746	h. sapiens metabolites
CHEBI has role	CHEBI:85234	human blood serum metabolites

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Excess subcutaneous fat	indication	248302001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.92	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
fMet-Leu-Phe receptor	GPCR	P21462	FPR1_HUMAN	ANTAGONIST	Ki	4		IUPHAR
G-protein coupled bile acid receptor 1	GPCR	Q8TDU6	GPBAR_HUMAN	AGONIST	EC50	6.20		IUPHAR
Cell membrane	Cell membrane			OTHER				DRUG LABEL	DRUG LABEL
Steroid Delta-isomerase	Unclassified		SDIS_PSEPU		Kd	4.80		CHEMBL

External reference:

ID	Source
4018928	VANDF
4035848	VANDF
C4305918	UMLSCUI
CHEBI:23614	CHEBI
DHO	PDB_CHEM_ID
DXC	PDB_CHEM_ID
CHEMBL406393	ChEMBL_ID
CHEMBL514674	ChEMBL_ID
CHEMBL1208257	ChEMBL_ID
CHEMBL453873	ChEMBL_ID
DB05780	DRUGBANK_ID
DB03619	DRUGBANK_ID
D003840	MESH_DESCRIPTOR_UI
222528	PUBCHEM_CID
610	IUPHAR_LIGAND_ID
9540	INN_ID
005990WHZZ	UNII
1367220	RXNORM
14975	MMSL
234529	MMSL
d08364	MMSL
001205	NDDF
010267	NDDF
781373006	SNOMEDCT_US
78258003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
KYBELLA	HUMAN PRESCRIPTION DRUG LABEL	1	61168-101	INJECTION, SOLUTION	20 mg	SUBCUTANEOUS	NDA	27 sections