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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4290	7487-88-9

Description:

Molecule	Description
Synonyms: magnesium sulfate sulfuric acid magnesium salt epsom salt magnesium sulphate magnesium sulfate heptahydrate magnesium sulfate, unspecified magnesium sulfate anhydrous	A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083) Molecular weight: 120.36 Formula: MgO4S CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

magnesium sulfate
sulfuric acid magnesium salt
epsom salt
magnesium sulphate
magnesium sulfate heptahydrate
magnesium sulfate, unspecified
magnesium sulfate anhydrous

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Molecular weight: 120.36
Formula: MgO4S
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
7	g	O
3	g	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Jan. 22, 2021	PMDA	NIHON PHARMACEUTICAL CO., LTD.
Oct. 6, 1981	FDA	BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	444.04	9.30	316	73495	38446	90516190
Macular degeneration	379.33	9.30	285	73526	37685	90516951
Premature baby	232.32	9.30	180	73631	24897	90529739
Pemphigus	227.18	9.30	9	73802	326855	90227781
Normal labour	213.20	9.30	57	73754	560	90554076
Synovitis	205.07	9.30	17	73794	329735	90224901
Hypermagnesaemia	202.12	9.30	64	73747	1185	90553451
Hand deformity	190.74	9.30	13	73798	296349	90258287
Systemic lupus erythematosus	187.77	9.30	34	73777	361862	90192774
Glossodynia	178.71	9.30	25	73786	321754	90232882
Exposure during pregnancy	177.34	9.30	510	73301	237900	90316736
Pericarditis	162.37	9.30	16	73795	270135	90284501
Contraindicated product administered	161.96	9.30	32	73779	320107	90234529
Delivery	160.72	9.30	59	73752	1734	90552902
Anti-cyclic citrullinated peptide antibody positive	147.48	9.30	12	73799	236421	90318215
Treatment failure	146.34	9.30	34	73777	303894	90250742
Pulmonary oedema	144.06	9.30	213	73598	61867	90492769
Wound	141.76	9.30	36	73775	302944	90251692
Arthropathy	127.17	9.30	70	73741	366172	90188464
Joint swelling	121.08	9.30	139	73672	503161	90051475
Paraesthesia oral	121.05	9.30	139	73672	31520	90523116
Low birth weight baby	119.61	9.30	82	73729	9385	90545251
Drug intolerance	113.85	9.30	118	73693	447473	90107163
Duodenal ulcer perforation	110.04	9.30	23	73788	221265	90333371
Helicobacter infection	109.92	9.30	25	73786	226825	90327811
Product use issue	108.92	9.30	67	73744	329852	90224784
Hepatic enzyme increased	108.74	9.30	81	73730	360655	90193981
Folliculitis	108.55	9.30	18	73793	204335	90350301
Rheumatoid factor positive	106.23	9.30	9	73802	171641	90382995
Diabetes insipidus	103.11	9.30	51	73760	3161	90551475
PCO2 increased	102.34	9.30	39	73772	1274	90553362
Lower respiratory tract infection	99.13	9.30	40	73771	250619	90304017
Chronic sinusitis	95.23	9.30	107	73704	23695	90530941
Completed suicide	94.35	9.30	6	73805	145052	90409584
Irritable bowel syndrome	92.58	9.30	27	73784	207421	90347215
Blood pH decreased	92.31	9.30	44	73767	2514	90552122
Therapeutic product effect decreased	92.11	9.30	56	73755	277515	90277121
Muscle injury	90.68	9.30	17	73794	176637	90377999
Maternal exposure during pregnancy	87.70	9.30	547	73264	359516	90195120
Procedural pain	83.99	9.30	119	73692	33241	90521395
Foetal exposure during pregnancy	83.66	9.30	136	73675	42839	90511797
Vaginal flatulence	82.29	9.30	74	73737	12564	90542072
Blood bicarbonate decreased	78.38	9.30	42	73769	3077	90551559
Discomfort	78.34	9.30	65	73746	274270	90280366
Hypersensitivity	78.04	9.30	158	73653	454519	90100117
Rheumatic fever	78.02	9.30	15	73796	153106	90401530
Female genital tract fistula	77.84	9.30	84	73727	17784	90536852
Radiculopathy	77.14	9.30	85	73726	18420	90536216
Rheumatoid arthritis	76.92	9.30	110	73701	362504	90192132
Impaired healing	76.65	9.30	48	73763	234151	90320485
Mitochondrial DNA mutation	76.32	9.30	24	73787	434	90554202
Proctitis	74.08	9.30	76	73735	15183	90539453
Postpartum haemorrhage	73.76	9.30	37	73774	2364	90552272
Alopecia	72.84	9.30	187	73624	494884	90059752
C-reactive protein abnormal	72.84	9.30	9	73802	127420	90427216
Blister	72.09	9.30	61	73750	254937	90299699
Sleep disorder due to general medical condition, insomnia type	71.38	9.30	10	73801	128684	90425952
Liver injury	71.13	9.30	25	73786	170542	90384094
Propofol infusion syndrome	70.53	9.30	30	73781	1309	90553327
Ill-defined disorder	69.12	9.30	32	73779	184859	90369777
Vaginal discharge	68.64	9.30	82	73729	19382	90535254
Unevaluable event	68.12	9.30	143	73668	54705	90499931
Joint range of motion decreased	67.62	9.30	14	73797	135629	90419007
Renal ischaemia	67.50	9.30	24	73787	642	90553994
Type 2 diabetes mellitus	67.42	9.30	41	73770	203203	90351433
Colitis	65.41	9.30	163	73648	69779	90484857
Intentional product use issue	64.92	9.30	49	73762	216843	90337793
Bursitis	64.78	9.30	14	73797	131640	90422996
Pre-eclampsia	64.76	9.30	61	73750	10987	90543649
Facet joint syndrome	64.18	9.30	4	73807	98385	90456251
Swollen joint count increased	63.20	9.30	8	73803	111198	90443438
Fibromyalgia	62.51	9.30	46	73765	206223	90348413
Anaemia	61.86	9.30	495	73316	352307	90202329
Swelling	61.84	9.30	158	73653	418900	90135736
Gastrointestinal disorder	60.44	9.30	72	73739	256615	90298021
General physical health deterioration	60.39	9.30	124	73687	354991	90199645
Diarrhoea	59.90	9.30	1085	72726	938105	89616531
Hypotension	55.11	9.30	453	73358	324944	90229692
Abdominal discomfort	53.44	9.30	204	73607	477124	90077512
Drug hypersensitivity	53.29	9.30	196	73615	463413	90091223
Deep vein thrombosis	52.32	9.30	179	73632	91441	90463195
PO2 increased	50.38	9.30	21	73790	871	90553765
Respiratory failure	49.94	9.30	210	73601	118208	90436428
Neonatal intestinal perforation	49.84	9.30	10	73801	21	90554615
Breast cancer stage III	48.17	9.30	6	73805	84441	90470195
Arthralgia	47.87	9.30	405	73406	778117	89776519
Constipation	47.81	9.30	391	73420	280004	90274632
Acute respiratory failure	46.59	9.30	106	73705	42812	90511824
Blood gases abnormal	46.42	9.30	20	73791	901	90553735
Mobility decreased	45.69	9.30	84	73727	250650	90303986
Blood magnesium decreased	45.58	9.30	60	73751	15633	90539003
Caesarean section	44.90	9.30	65	73746	18512	90536124
CSF oligoclonal band present	44.76	9.30	16	73795	435	90554201
Hypomagnesaemia	44.44	9.30	93	73718	35495	90519141
Musculoskeletal stiffness	44.33	9.30	111	73700	296421	90258215
Inflammation	44.30	9.30	48	73763	178544	90376092
Drug abuse	44.27	9.30	7	73804	82340	90472296
Lip dry	43.47	9.30	14	73797	100941	90453695
Wheezing	43.16	9.30	80	73731	238000	90316636
Obesity	43.07	9.30	16	73795	105491	90449145
Haematochezia	42.65	9.30	141	73670	70772	90483864
Neonatal respiratory distress syndrome	41.89	9.30	28	73783	3073	90551563
Blood magnesium increased	41.83	9.30	29	73782	3379	90551257
Product dose omission issue	41.55	9.30	391	73420	291296	90263340
Dehydration	40.94	9.30	285	73526	194162	90360474
Foetal death	40.90	9.30	66	73745	20657	90533979
Gene mutation	40.79	9.30	24	73787	2106	90552530
Oral candidiasis	40.08	9.30	89	73722	35366	90519270
Asthma	39.93	9.30	86	73725	242074	90312562
Neuropathy peripheral	39.69	9.30	218	73593	136752	90417884
Grip strength decreased	39.57	9.30	13	73798	92563	90462073
Rectal haemorrhage	39.07	9.30	152	73659	82592	90472044
Sepsis	38.71	9.30	265	73546	179549	90375087
Blood cholesterol increased	38.50	9.30	69	73742	207943	90346693
Hypocalcaemia	37.79	9.30	97	73714	42271	90512365
Sleep disorder	37.28	9.30	65	73746	197965	90356671
Encephalopathy	37.04	9.30	102	73709	46342	90508294
Nausea	36.97	9.30	1173	72638	1109143	89445493
Abdominal pain	36.93	9.30	488	73323	395233	90159403
Infection	36.58	9.30	161	73650	361933	90192703
C-reactive protein increased	36.50	9.30	57	73754	181332	90373304
Psoriatic arthropathy	36.08	9.30	83	73728	228252	90326384
Vaginal haemorrhage	35.92	9.30	79	73732	31192	90523444
Device expulsion	35.84	9.30	93	73718	40793	90513843
Peripheral venous disease	35.49	9.30	12	73799	83909	90470727
Pleocytosis	35.34	9.30	17	73794	991	90553645
Full blood count decreased	35.23	9.30	76	73735	29613	90525023
Cytokine release syndrome	34.81	9.30	73	73738	27900	90526736
COVID-19	34.03	9.30	53	73758	168790	90385846
Infusion related reaction	33.25	9.30	201	73610	416579	90138057
Apgar score low	32.49	9.30	17	73794	1186	90553450
Chills	32.36	9.30	201	73610	131780	90422856
Hypoxia	31.78	9.30	130	73681	72269	90482367
Hypokalaemia	31.72	9.30	199	73612	130917	90423719
Urticaria thermal	31.63	9.30	13	73798	520	90554116
Premature labour	31.16	9.30	46	73765	13330	90541306
Airway peak pressure increased	31.09	9.30	12	73799	406	90554230
Epilepsy	31.06	9.30	14	73797	82192	90472444
Blood lactic acid increased	30.98	9.30	37	73774	8741	90545895
Frequent bowel movements	30.56	9.30	109	73702	56826	90497810
Haemoglobin decreased	30.41	9.30	231	73580	161725	90392911
Hypervolaemia	30.26	9.30	76	73735	32681	90521955
Platelet count decreased	30.15	9.30	203	73608	136766	90417870
Maternal exposure during delivery	30.06	9.30	25	73786	3821	90550815
Lung hyperinflation	29.99	9.30	17	73794	1391	90553245
Febrile neutropenia	29.81	9.30	226	73585	158123	90396513
Oxygen saturation abnormal	29.69	9.30	26	73785	4262	90550374
HELLP syndrome	29.50	9.30	16	73795	1201	90553435
Condition aggravated	29.28	9.30	327	73484	595218	89959418
Device dislocation	29.04	9.30	73	73738	31409	90523227
Foetal growth restriction	29.02	9.30	37	73774	9343	90545293
Neuromuscular blockade	28.99	9.30	11	73800	355	90554281
Deep vein thrombosis postoperative	28.46	9.30	11	73800	70798	90483838
Respiratory acidosis	28.29	9.30	34	73777	8085	90546551
Wound infection	28.20	9.30	27	73784	106375	90448261
Therapy cessation	28.15	9.30	79	73732	36282	90518354
Prescribed overdose	28.00	9.30	23	73788	97602	90457034
Myelosuppression	27.82	9.30	5	73806	53586	90501050
Pulmonary fibrosis	27.66	9.30	28	73783	107475	90447161
Atrial fibrillation	27.62	9.30	195	73616	133416	90421220
Feeling abnormal	27.30	9.30	231	73580	167004	90387632
Weight increased	27.17	9.30	214	73597	417713	90136923
Nasopharyngitis	26.68	9.30	208	73603	406896	90147740
Night sweats	26.35	9.30	40	73771	128726	90425910
Plasma cell myeloma	26.19	9.30	83	73728	40745	90513891
Adjustment disorder with depressed mood	26.02	9.30	7	73804	56746	90497890
Neuromuscular block prolonged	25.95	9.30	12	73799	640	90553996
Pleural effusion	25.87	9.30	168	73643	111823	90442813
Emotional distress	25.82	9.30	77	73734	36585	90518051
Skin discolouration	25.66	9.30	87	73724	44228	90510408
PO2 decreased	25.61	9.30	16	73795	1565	90553071
Foetal heart rate deceleration abnormality	25.48	9.30	12	73799	667	90553969
Stomatitis	25.45	9.30	126	73685	274572	90280064
Left ventricular dysfunction	25.32	9.30	44	73767	14625	90540011
Blood potassium decreased	25.30	9.30	91	73720	47636	90507000
Blepharospasm	25.12	9.30	7	73804	55438	90499198
Administration site erythema	24.99	9.30	13	73798	896	90553740
Craniotabes	24.46	9.30	4	73807	0	90554636
Osteoarthritis	24.30	9.30	80	73731	195650	90358986
Nail disorder	24.03	9.30	9	73802	59058	90495578
Suicide attempt	23.90	9.30	16	73795	75383	90479253
Acute pulmonary oedema	23.85	9.30	34	73777	9546	90545090
Dislocation of vertebra	23.67	9.30	8	73803	55960	90498676
Intentional overdose	23.51	9.30	25	73786	93809	90460827
Fall	23.38	9.30	535	73276	481275	90073361
Colitis ulcerative	23.20	9.30	104	73707	60162	90494474
Flatulence	22.89	9.30	80	73731	41287	90513349
Pelvic pain	22.61	9.30	43	73768	15314	90539322
Fear	22.60	9.30	45	73766	16577	90538059
Onychomadesis	22.40	9.30	5	73806	45993	90508643
Weight decreased	22.37	9.30	434	73377	379476	90175160
Status asthmaticus	22.29	9.30	12	73799	887	90553749
Neonatal gastrointestinal haemorrhage	21.97	9.30	5	73806	23	90554613
Red blood cell sedimentation rate increased	21.84	9.30	21	73790	82574	90472062
Toxicity to various agents	21.81	9.30	141	73670	287705	90266931
Lung disorder	21.69	9.30	57	73754	149826	90404810
Confusional state	21.43	9.30	206	73605	385999	90168637
Flushing	21.20	9.30	134	73677	88357	90466279
Blood calcium decreased	20.88	9.30	63	73748	30119	90524517
Neonatal disorder	20.80	9.30	10	73801	582	90554054
Adverse event	20.79	9.30	40	73771	117378	90437258
Back pain	20.63	9.30	368	73443	316807	90237829
Hyperkalaemia	20.58	9.30	106	73705	64858	90489778
Drug-induced liver injury	20.53	9.30	26	73785	90292	90464344
Torsade de pointes	20.52	9.30	41	73770	15141	90539495
Off label use	20.46	9.30	714	73097	1101538	89453098
Respiratory distress	20.42	9.30	74	73737	38872	90515764
Intentional product misuse	20.16	9.30	26	73785	89578	90465058
Hypercapnia	20.12	9.30	26	73785	6651	90547985
Lethargy	19.99	9.30	103	73708	63036	90491600
Coeliac disease	19.53	9.30	6	73805	44604	90510032
Mental status changes	19.42	9.30	80	73731	44599	90510037
Ventricular extrasystoles	19.39	9.30	37	73774	13213	90541423
Pneumonia	19.30	9.30	667	73144	637392	89917244
Schizencephaly	19.12	9.30	8	73803	335	90554301
Hypercholesterolaemia	19.08	9.30	33	73778	100859	90453777
Cerebral haemorrhage foetal	19.01	9.30	8	73803	340	90554296
Urticaria	19.01	9.30	163	73648	312571	90242065
Urinary tract infection	18.62	9.30	351	73460	305281	90249355
International normalised ratio increased	18.47	9.30	82	73729	47234	90507402
Sciatica	18.42	9.30	34	73777	101348	90453288
Pulmonary hypertension	18.38	9.30	76	73735	42447	90512189
Product use in unapproved indication	18.38	9.30	180	73631	336056	90218580
Nail bed tenderness	18.37	9.30	8	73803	370	90554266
Hip arthroplasty	18.32	9.30	21	73790	76187	90478449
Immune effector cell-associated neurotoxicity syndrome	18.23	9.30	23	73788	5745	90548891
Muscle spasms	18.10	9.30	297	73514	251586	90303050
Loss of personal independence in daily activities	18.04	9.30	54	73757	136051	90418585
Unresponsive to stimuli	17.97	9.30	70	73741	38051	90516585
Pulmonary embolism	17.92	9.30	174	73637	130646	90423990
Knee arthroplasty	17.84	9.30	25	73786	83157	90471479
Hypophagia	17.77	9.30	67	73744	35870	90518766
Autoimmune disorder	17.54	9.30	22	73789	76722	90477914
Haematocrit decreased	17.48	9.30	74	73737	41758	90512878
Electroencephalogram abnormal	17.39	9.30	19	73792	4077	90550559
Delayed fontanelle closure	17.14	9.30	4	73807	21	90554615
Cardiac arrest	17.14	9.30	145	73666	104790	90449846
X-ray abnormal	16.75	9.30	8	73803	45416	90509220
Endometritis	16.61	9.30	11	73800	1189	90553447
Transfusion	16.60	9.30	41	73770	17447	90537189
Hepatitis	16.46	9.30	20	73791	70719	90483917
Tachypnoea	16.20	9.30	46	73765	21263	90533373
Aspartate aminotransferase increased	16.16	9.30	141	73670	102796	90451840
Liver disorder	16.15	9.30	48	73763	121221	90433415
White blood cell count decreased	15.94	9.30	207	73604	166902	90387734
Infantile apnoea	15.91	9.30	11	73800	1276	90553360
Prescribed underdose	15.64	9.30	23	73788	74996	90479640
Blood albumin decreased	15.53	9.30	39	73772	16764	90537872
Failure to thrive	15.53	9.30	26	73785	8385	90546251
Hot flush	15.46	9.30	92	73719	59396	90495240
Immunodeficiency	15.36	9.30	8	73803	43226	90511410
Clonus	15.20	9.30	21	73790	5729	90548907
Finger deformity	15.19	9.30	4	73807	32893	90521743
Product compounding quality issue	15.18	9.30	4	73807	37	90554599
Peripheral swelling	15.10	9.30	241	73570	412865	90141771
Antinuclear antibody positive	15.02	9.30	27	73784	9214	90545422
Cardiac failure congestive	14.88	9.30	134	73677	98560	90456076
Nervousness	14.82	9.30	61	73750	33995	90520641
Arrhythmia	14.78	9.30	71	73740	42261	90512375
Drug tolerance decreased	14.66	9.30	4	73807	32126	90522510
Asthenia	14.42	9.30	551	73260	533200	90021436
Tremor	14.30	9.30	189	73622	152984	90401652
Dizziness	14.23	9.30	601	73210	588683	89965953
Hyporeflexia	14.23	9.30	13	73798	2253	90552383
Cystitis-like symptom	14.19	9.30	3	73808	9	90554627
Blood culture positive	14.13	9.30	19	73792	5053	90549583
Neonatal infection	14.10	9.30	6	73805	262	90554374
Patent ductus arteriosus	14.10	9.30	18	73793	4551	90550085
Product quality issue	14.06	9.30	27	73784	79298	90475338
Road traffic accident	14.04	9.30	43	73768	107583	90447053
Intestinal dilatation	14.01	9.30	13	73798	2297	90552339
Dyspnoea	14.00	9.30	863	72948	880092	89674544
Cyanosis	13.83	9.30	41	73770	19414	90535222
Food interaction	13.77	9.30	10	73801	1254	90553382
Overdose	13.66	9.30	74	73737	157635	90397001
Urine output decreased	13.53	9.30	31	73780	12572	90542064
Sleep disorder due to a general medical condition	13.51	9.30	10	73801	44728	90509908
Nasal congestion	13.48	9.30	115	73696	83299	90471337
Small intestinal obstruction	13.47	9.30	43	73768	21191	90533445
Electrocardiogram QT prolonged	13.40	9.30	103	73708	72353	90482283
Eclampsia	13.34	9.30	7	73804	491	90554145
Atelectasis	13.33	9.30	47	73764	24362	90530274
Seizure	13.29	9.30	186	73625	152443	90402193
Hypertension	13.25	9.30	278	73533	457254	90097382
Renal failure	13.22	9.30	164	73647	130843	90423793
Onychomycosis	13.16	9.30	7	73804	37369	90517267
Foetal distress syndrome	13.16	9.30	11	73800	1694	90552942
Pulmonary arterial hypertension	13.09	9.30	49	73762	26138	90528498
Therapeutic response decreased	13.07	9.30	34	73777	89695	90464941
Acute kidney injury	12.90	9.30	347	73464	320040	90234596
Vision blurred	12.87	9.30	142	73669	110151	90444485
Fallot's tetralogy	12.84	9.30	4	73807	70	90554566
Erythema	12.84	9.30	260	73551	228986	90325650
Lower limb fracture	12.55	9.30	32	73779	84981	90469655
Vitamin B6 increased	12.53	9.30	4	73807	76	90554560
Metabolic acidosis	12.53	9.30	83	73728	55593	90499043
C-reactive protein	12.39	9.30	5	73806	31362	90523274
Bone erosion	12.33	9.30	15	73796	53006	90501630
Bronchospasm	12.29	9.30	41	73770	20668	90533968
Bacteraemia	12.23	9.30	43	73768	22257	90532379
Anhedonia	12.14	9.30	28	73783	11403	90543233
Shock	12.09	9.30	51	73760	28727	90525909
Delirium	12.04	9.30	44	73767	104315	90450321
Device related sepsis	11.92	9.30	17	73794	4776	90549860
Diastolic hypotension	11.90	9.30	4	73807	90	90554546
Thrombosis	11.85	9.30	101	73710	73150	90481486
Taste disorder	11.76	9.30	20	73791	61526	90493110
Pancreatitis chronic	11.75	9.30	13	73798	2830	90551806
Laboratory test abnormal	11.70	9.30	66	73745	41788	90512848
Dizziness postural	11.70	9.30	24	73787	9029	90545607
Blood alkaline phosphatase increased	11.64	9.30	73	73738	48006	90506630
Dysgeusia	11.62	9.30	78	73733	52482	90502154
Septic shock	11.55	9.30	112	73699	84048	90470588
Encephalitis	11.53	9.30	27	73784	11107	90543529
Gait inability	11.46	9.30	71	73740	146385	90408251
Influenza like illness	11.42	9.30	108	73703	80503	90474133
Acute respiratory distress syndrome	11.41	9.30	50	73761	28636	90526000
Clostridium difficile infection	11.38	9.30	59	73752	36186	90518450
Hypoventilation neonatal	11.36	9.30	3	73808	28	90554608
Burkholderia test positive	11.33	9.30	5	73806	239	90554397
Cellulitis	11.31	9.30	119	73692	91218	90463418
Pulmonary valve incompetence	11.25	9.30	10	73801	1671	90552965
Respiratory rate decreased	11.21	9.30	15	73796	3968	90550668
Injection site bruising	11.19	9.30	77	73734	52230	90502406
Drug reaction with eosinophilia and systemic symptoms	11.15	9.30	11	73800	42747	90511889
Product complaint	11.11	9.30	30	73781	13470	90541166
Intentional self-injury	11.07	9.30	5	73806	29329	90525307
Peptic ulcer perforation	11.04	9.30	6	73805	452	90554184
Ureteric stenosis	11.02	9.30	7	73804	705	90553931
Anaphylactic shock	11.01	9.30	6	73805	31611	90523025
Injection site haemorrhage	10.99	9.30	49	73762	28269	90526367
Maternal drugs affecting foetus	10.97	9.30	17	73794	5138	90549498
Staphylococcal infection	10.77	9.30	72	73739	48367	90506269
Osmotic demyelination syndrome	10.72	9.30	8	73803	1046	90553590
Pain	10.69	9.30	684	73127	995657	89558979
Hypotonia neonatal	10.57	9.30	9	73802	1421	90553215
Plasma cell myeloma recurrent	10.52	9.30	15	73796	4213	90550423
Hip fracture	10.50	9.30	54	73757	33023	90521613
Pigmentation disorder	10.47	9.30	18	73793	5931	90548705
Prothrombin time prolonged	10.45	9.30	24	73787	9748	90544888
Aplastic anaemia	10.44	9.30	29	73782	13240	90541396
Vulvovaginal swelling	10.30	9.30	7	73804	789	90553847
Osteonecrosis of jaw	10.27	9.30	10	73801	39093	90515543
Vascular resistance systemic decreased	10.26	9.30	4	73807	139	90554497
Lupus vulgaris	10.21	9.30	13	73798	45046	90509590
Injury	10.21	9.30	107	73704	197242	90357394
Administration site swelling	10.20	9.30	9	73802	1490	90553146
Therapeutic response shortened	10.16	9.30	3	73808	22876	90531760
Tidal volume decreased	10.12	9.30	3	73808	44	90554592
Eye swelling	10.05	9.30	49	73762	29337	90525299
Disability	10.04	9.30	11	73800	40734	90513902
Cardiac pacemaker insertion	10.04	9.30	15	73796	4392	90550244
Laryngeal pain	10.00	9.30	15	73796	4407	90550229
Oedema peripheral	10.00	9.30	278	73533	257637	90296999
Small for dates baby	9.95	9.30	16	73795	4991	90549645
Stillbirth	9.94	9.30	20	73791	7423	90547213
Apnoea	9.94	9.30	23	73788	9391	90545245
Ventricular hypertrophy	9.90	9.30	13	73798	3378	90551258
Adverse reaction	9.83	9.30	6	73805	29706	90524930
Generalised oedema	9.82	9.30	36	73775	19017	90535619
Respiratory rate increased	9.78	9.30	32	73779	15969	90538667
Renal injury	9.71	9.30	24	73787	10219	90544417
Intestinal ischaemia	9.70	9.30	22	73789	8861	90545775
Right ventricular failure	9.65	9.30	36	73775	19169	90535467
Interstitial lung disease	9.63	9.30	31	73780	76374	90478262
Occult blood positive	9.61	9.30	14	73797	4009	90550627
Therapy partial responder	9.59	9.30	3	73808	22040	90532596
Coagulopathy	9.58	9.30	41	73770	23248	90531388
Therapy change	9.53	9.30	21	73790	8301	90546335
Blood pressure diastolic decreased	9.48	9.30	5	73806	26821	90527815
Hospice care	9.47	9.30	23	73788	9681	90544955
Leukocytosis	9.42	9.30	50	73761	30940	90523696

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature baby	145.99	10.89	146	42543	23007	42555639
Off label use	90.90	10.89	332	42357	638003	41940643
Adrenal suppression	84.49	10.89	33	42656	932	42577714
Low birth weight baby	80.36	10.89	72	42617	9883	42568763
Drug abuse	71.54	10.89	10	42679	104761	42473885
Gingival disorder	68.95	10.89	33	42656	1541	42577105
Completed suicide	59.67	10.89	12	42677	96453	42482193
Product use in unapproved indication	55.23	10.89	62	42627	184394	42394252
Foetal exposure during pregnancy	53.81	10.89	135	42554	47176	42531470
Toxicity to various agents	52.71	10.89	93	42596	229043	42349603
Skin irritation	42.72	10.89	45	42644	7529	42571117
Cytokine release syndrome	41.48	10.89	118	42571	44409	42534237
Drug ineffective	41.05	10.89	419	42270	629778	41948868
Tachycardia foetal	40.11	10.89	15	42674	375	42578271
Intentional product misuse	39.77	10.89	7	42682	61893	42516753
Oral disorder	37.25	10.89	34	42655	4778	42573868
Plasma cell myeloma	35.80	10.89	117	42572	47461	42531185
Apgar score low	35.61	10.89	18	42671	947	42577699
Unevaluable event	35.03	10.89	94	42595	34194	42544452
Drug interaction	34.46	10.89	144	42545	266855	42311791
Pneumonia	31.09	10.89	594	42095	421555	42157091
Respiratory disorder	30.51	10.89	68	42621	22017	42556629
Blood potassium decreased	28.43	10.89	63	42626	20321	42558325
Diarrhoea	28.20	10.89	631	42058	460218	42118428
Hypermagnesaemia	28.02	10.89	11	42678	315	42578331
Foetal distress syndrome	26.80	10.89	16	42673	1170	42577476
Fatigue	26.49	10.89	596	42093	435045	42143601
Asthenia	25.99	10.89	410	42279	280383	42298263
General physical health deterioration	24.54	10.89	74	42615	151172	42427474
Dehydration	24.49	10.89	233	42456	141534	42437112
Small intestinal obstruction	24.09	10.89	53	42636	17008	42561638
Fall	23.44	10.89	347	42342	234173	42344473
Burkholderia test positive	23.30	10.89	14	42675	1036	42577610
Anhedonia	22.89	10.89	33	42656	7607	42571039
Immune effector cell-associated neurotoxicity syndrome	22.89	10.89	37	42652	9424	42569222
Laboratory test abnormal	22.48	10.89	62	42627	22916	42555730
Suicide attempt	22.47	10.89	9	42680	46091	42532555
Sepsis	22.35	10.89	301	42388	199033	42379613
Respiratory failure	21.83	10.89	210	42479	127922	42450724
Product use issue	21.65	10.89	27	42662	76724	42501922
Intentional product use issue	21.63	10.89	24	42665	71809	42506837
Injury	21.62	10.89	60	42629	22256	42556390
Fear	21.42	10.89	39	42650	10926	42567720
White blood cell count decreased	21.37	10.89	186	42503	110210	42468436
Myelosuppression	21.25	10.89	7	42682	40454	42538192
Intentional overdose	20.65	10.89	13	42676	51443	42527203
Mental status changes	20.41	10.89	90	42599	42025	42536621
Overdose	18.92	10.89	49	42640	105215	42473431
Full blood count decreased	18.66	10.89	54	42635	20506	42558140
Lip swelling	18.23	10.89	51	42638	19002	42559644
Constipation	18.15	10.89	245	42444	162046	42416600
Respiratory tract infection bacterial	17.81	10.89	15	42674	1894	42576752
Platelet count decreased	17.08	10.89	213	42476	138368	42440278
Bradycardia foetal	17.03	10.89	8	42681	358	42578288
Intraventricular haemorrhage neonatal	16.91	10.89	8	42681	364	42578282
Treatment failure	16.67	10.89	23	42666	62601	42516045
COVID-19	16.55	10.89	60	42629	115888	42462758
Caesarean section	16.54	10.89	15	42674	2091	42576555
Complication of device removal	16.48	10.89	5	42684	64	42578582
Hypoxia	16.45	10.89	123	42566	69663	42508983
Foetal heart rate deceleration abnormality	16.26	10.89	9	42680	570	42578076
Back pain	16.25	10.89	215	42474	141561	42437085
Drug resistance	16.19	10.89	7	42682	34241	42544405
Pantoea agglomerans infection	15.81	10.89	5	42684	74	42578572
Adrenal insufficiency	15.57	10.89	48	42641	18876	42559770
Hepatic cytolysis	15.27	10.89	4	42685	26840	42551806
Renal injury	14.97	10.89	36	42653	12244	42566402
Acute respiratory failure	14.47	10.89	77	42612	38781	42539865
Product contamination	14.06	10.89	10	42679	985	42577661
Viral infection	14.05	10.89	52	42637	22431	42556215
Maternal drugs affecting foetus	13.63	10.89	18	42671	3821	42574825
Blood albumin decreased	13.55	10.89	40	42649	15362	42563284
Splenic vein thrombosis	13.54	10.89	8	42681	574	42578072
Patent ductus arteriosus	13.44	10.89	17	42672	3459	42575187
Electrocardiogram QT prolonged	13.34	10.89	88	42601	47857	42530789
Agranulocytosis	13.33	10.89	7	42682	30605	42548041
Drug intolerance	13.28	10.89	39	42650	80385	42498261
Blood magnesium decreased	13.25	10.89	26	42663	7700	42570946
Hypotension	13.04	10.89	344	42345	257287	42321359
Respiratory acidosis	12.98	10.89	23	42666	6308	42572338
Rheumatoid arthritis	12.97	10.89	14	42675	42426	42536220
Anorgasmia	12.87	10.89	10	42679	1127	42577519
Neonatal respiratory distress syndrome	12.81	10.89	19	42670	4494	42574152
Inappropriate schedule of product administration	12.79	10.89	51	42638	95851	42482795
Mixed dementia	12.78	10.89	6	42683	268	42578378
Torsade de pointes	12.48	10.89	27	42662	8567	42570079
Hypervolaemia	12.43	10.89	51	42638	23074	42555572
Drug-induced liver injury	12.41	10.89	12	42677	38261	42540385
Neonatal asphyxia	12.28	10.89	7	42682	469	42578177
Ureteric stenosis	12.00	10.89	10	42679	1244	42577402
Oesophagitis	11.92	10.89	38	42651	15209	42563437
Muscular weakness	11.90	10.89	132	42557	83366	42495280
Apnoea	11.89	10.89	25	42664	7778	42570868
Painful ejaculation	11.82	10.89	5	42684	174	42578472
Haemoglobin decreased	11.68	10.89	192	42497	132279	42446367
Diabetes mellitus	11.55	10.89	27	42662	60060	42518586
Transverse presentation	11.39	10.89	4	42685	83	42578563
Therapy partial responder	11.36	10.89	3	42686	20018	42558628
Behaviour disorder	11.22	10.89	23	42666	7031	42571615
Muscle spasms	10.92	10.89	133	42556	85911	42492735

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	292.23	9.49	226	92106	30406	110466561
Synovitis	184.71	9.49	11	92321	274081	110222886
Exposure during pregnancy	166.00	9.49	405	91927	167019	110329948
Pemphigus	146.44	9.49	8	92324	214562	110282405
Hypermagnesaemia	146.37	9.49	54	92278	1569	110495398
Completed suicide	143.45	9.49	17	92315	242364	110254603
Hand deformity	135.25	9.49	13	92319	218493	110278474
Systemic lupus erythematosus	125.79	9.49	29	92303	254309	110242658
Macular degeneration	125.24	9.49	120	92212	21539	110475428
Helicobacter infection	117.53	9.49	9	92323	181868	110315099
Drug intolerance	117.51	9.49	100	92232	406412	110090555
Anti-cyclic citrullinated peptide antibody positive	112.17	9.49	11	92321	181973	110314994
Glossodynia	108.42	9.49	26	92306	221978	110274989
Contraindicated product administered	106.68	9.49	37	92295	248230	110248737
Pericarditis	106.35	9.49	26	92306	219088	110277879
Paraesthesia oral	105.00	9.49	135	92197	33536	110463431
Joint swelling	103.12	9.49	131	92201	442714	110054253
Product use in unapproved indication	100.42	9.49	136	92196	447241	110049726
Treatment failure	99.04	9.49	54	92278	277180	110219787
Drug abuse	96.61	9.49	16	92316	177395	110319572
Hepatic enzyme increased	95.11	9.49	77	92255	320815	110176152
Diabetes insipidus	93.86	9.49	62	92270	6508	110490459
Arthropathy	90.30	9.49	65	92267	287457	110209510
PCO2 increased	89.17	9.49	40	92292	1937	110495030
Procedural pain	87.31	9.49	127	92205	35438	110461529
Product use issue	84.87	9.49	81	92251	311614	110185353
Intentional product use issue	84.67	9.49	51	92281	247855	110249112
Chronic sinusitis	83.65	9.49	104	92228	24980	110471987
Vaginal flatulence	81.27	9.49	73	92259	12071	110484896
Folliculitis	81.14	9.49	20	92312	167633	110329334
Rheumatoid factor positive	81.00	9.49	8	92324	131632	110365335
Duodenal ulcer perforation	80.73	9.49	24	92308	177676	110319291
Cytokine release syndrome	80.48	9.49	180	92152	70126	110426841
C-reactive protein abnormal	79.50	9.49	8	92324	129687	110367280
Wound	78.99	9.49	49	92283	234388	110262579
Blood pH decreased	78.94	9.49	49	92283	4620	110492347
Female genital tract fistula	77.99	9.49	82	92250	16437	110480530
Radiculopathy	77.40	9.49	88	92244	19248	110477719
Unevaluable event	76.22	9.49	159	92173	59068	110437899
Lower respiratory tract infection	74.98	9.49	56	92276	243050	110253917
Mitochondrial DNA mutation	74.82	9.49	24	92308	452	110496515
Respiratory failure	74.16	9.49	366	91966	214966	110282001
Type 2 diabetes mellitus	73.44	9.49	28	92304	177204	110319763
General physical health deterioration	72.65	9.49	154	92178	425141	110071826
Pulmonary oedema	71.09	9.49	215	92117	100444	110396523
Vaginal discharge	70.84	9.49	81	92251	17827	110479140
Toxicity to various agents	70.19	9.49	189	92143	480366	110016601
Pre-eclampsia	70.07	9.49	58	92274	8592	110488375
Irritable bowel syndrome	69.63	9.49	25	92307	164190	110332777
Fibromyalgia	69.17	9.49	28	92304	170881	110326086
Muscle injury	67.74	9.49	17	92315	140790	110356177
Dehydration	66.38	9.49	430	91902	279081	110217886
Proctitis	66.01	9.49	76	92256	16851	110480116
Bursitis	65.85	9.49	14	92318	129904	110367063
Hypotension	65.08	9.49	696	91636	523153	109973814
Rheumatoid arthritis	62.34	9.49	96	92236	299517	110197450
Off label use	61.58	9.49	883	91449	1499302	108997665
Joint range of motion decreased	60.00	9.49	14	92318	121818	110375149
Acute respiratory failure	59.13	9.49	167	92165	75093	110421874
Rheumatic fever	58.58	9.49	15	92317	122564	110374403
Sepsis	57.78	9.49	469	91863	326877	110170090
Colitis	57.34	9.49	202	92130	102121	110394846
Gastrointestinal disorder	56.86	9.49	71	92261	241881	110255086
Propofol infusion syndrome	56.40	9.49	32	92300	2557	110494410
Blood bicarbonate decreased	55.77	9.49	43	92289	5754	110491213
Diarrhoea	55.72	9.49	1293	91039	1138212	109358755
Maternal exposure during pregnancy	55.63	9.49	384	91948	254499	110242468
Sleep disorder due to general medical condition, insomnia type	54.34	9.49	11	92321	105632	110391335
Hypoxia	54.09	9.49	233	92099	129282	110367685
Therapeutic product effect decreased	53.04	9.49	76	92256	244240	110252727
Blister	52.11	9.49	68	92264	227308	110269659
Intentional product misuse	51.81	9.49	23	92309	132881	110364086
Alopecia	50.60	9.49	147	92185	364606	110132361
Deep vein thrombosis	50.46	9.49	241	92091	139646	110357321
Hypomagnesaemia	50.43	9.49	137	92195	60233	110436734
Mental status changes	49.49	9.49	158	92174	75964	110421003
Impaired healing	49.14	9.49	55	92277	196662	110300305
Mobility decreased	48.49	9.49	77	92255	237345	110259622
Blood magnesium decreased	48.49	9.49	71	92261	19925	110477042
Hypervolaemia	48.28	9.49	119	92213	49341	110447626
Foetal death	47.94	9.49	63	92269	15982	110480985
Blood potassium decreased	47.42	9.49	125	92207	53989	110442978
Swollen joint count increased	46.77	9.49	7	92325	83654	110413313
Hypersensitivity	46.31	9.49	177	92155	403821	110093146
Pneumonia	46.28	9.49	1006	91326	875708	109621259
Inflammation	46.14	9.49	56	92276	193182	110303785
Fear	45.94	9.49	75	92257	23118	110473849
Plasma cell myeloma	45.92	9.49	136	92196	62800	110434167
Breast cancer stage III	45.68	9.49	6	92326	79111	110417856
Device expulsion	44.59	9.49	87	92245	30804	110466163
Myelosuppression	44.21	9.49	12	92320	94328	110402639
CSF oligoclonal band present	43.66	9.49	16	92316	456	110496511
Abdominal pain	43.60	9.49	635	91697	512354	109984613
Ill-defined disorder	43.56	9.49	40	92292	156813	110340154
Swelling	43.40	9.49	149	92183	350892	110146075
Lip dry	42.82	9.49	15	92317	100068	110396899
C-reactive protein increased	42.34	9.49	73	92259	217846	110279121
Liver injury	42.20	9.49	38	92294	150375	110346592
Arthralgia	42.08	9.49	432	91900	779200	109717767
Emotional distress	41.77	9.49	106	92226	44741	110452226
Epilepsy	41.22	9.49	16	92316	100193	110396774
Discomfort	40.74	9.49	73	92259	214634	110282333
Obesity	40.57	9.49	22	92310	113329	110383638
Constipation	40.54	9.49	467	91865	357319	110139648
Peripheral venous disease	38.86	9.49	11	92321	84106	110412861
PO2 increased	38.70	9.49	21	92311	1538	110495429
Blood gases abnormal	38.54	9.49	20	92312	1338	110495629
COVID-19	38.34	9.49	93	92239	244967	110252000
Renal ischaemia	38.32	9.49	24	92308	2299	110494668
Hypokalaemia	38.10	9.49	272	92060	182176	110314791
Immune effector cell-associated neurotoxicity syndrome	38.06	9.49	54	92278	14728	110482239
Chills	38.01	9.49	281	92051	190299	110306668
Grip strength decreased	37.94	9.49	10	92322	80164	110416803
Vaginal haemorrhage	37.89	9.49	72	92260	25002	110471965
Product dose omission issue	37.80	9.49	423	91909	321359	110175608
Small intestinal obstruction	37.45	9.49	83	92249	32130	110464837
Haemoglobin decreased	37.39	9.49	344	91988	248383	110248584
Fall	36.91	9.49	708	91624	602774	109894193
Oral candidiasis	36.81	9.49	101	92231	44659	110452308
Respiratory acidosis	36.32	9.49	51	92281	13775	110483192
Anhedonia	36.29	9.49	54	92278	15374	110481593
Musculoskeletal stiffness	35.79	9.49	117	92215	279705	110217262
Osteoarthritis	35.64	9.49	61	92271	182562	110314405
Blood cholesterol increased	34.90	9.49	63	92269	184722	110312245
Asthma	34.60	9.49	101	92231	250190	110246777
Drug hypersensitivity	34.29	9.49	230	92102	453860	110043107
Torsade de pointes	34.28	9.49	65	92267	22535	110474432
Suicide attempt	34.27	9.49	22	92310	103372	110393595
Encephalopathy	33.97	9.49	146	92186	80909	110416058
Platelet count decreased	33.77	9.49	317	92015	230126	110266841
Caesarean section	33.42	9.49	49	92283	13768	110483199
Intentional overdose	33.13	9.49	37	92295	132464	110364503
Nausea	33.07	9.49	1302	91030	1234388	109262579
Anaemia	32.82	9.49	640	91692	546446	109950521
Electrocardiogram QT prolonged	31.82	9.49	177	92155	108783	110388184
Wheezing	31.76	9.49	108	92224	255122	110241845
Atrial fibrillation	31.73	9.49	312	92020	229330	110267637
Neuromuscular block prolonged	31.52	9.49	17	92315	1230	110495737
Urticaria thermal	31.36	9.49	13	92319	518	110496449
Hypocalcaemia	30.74	9.49	122	92210	65244	110431723
Hypercholesterolaemia	30.56	9.49	19	92313	90818	110406149
Premature labour	30.53	9.49	38	92294	9134	110487833
Administration site erythema	30.23	9.49	12	92320	427	110496540
Therapy cessation	29.97	9.49	94	92238	44763	110452204
Gene mutation	29.90	9.49	24	92308	3405	110493562
Hepatic cytolysis	29.88	9.49	5	92327	55048	110441919
Renal injury	29.85	9.49	55	92277	18658	110478309
Febrile neutropenia	29.24	9.49	398	91934	316369	110180598
Lung disorder	29.22	9.49	67	92265	179980	110316987
Nasopharyngitis	29.15	9.49	201	92131	394160	110102807
Pleocytosis	28.91	9.49	18	92314	1706	110495261
Sleep disorder	28.30	9.49	79	92253	198565	110298402
Rectal haemorrhage	28.19	9.49	184	92148	119649	110377318
Asthenia	27.95	9.49	763	91569	688236	109808731
Nail disorder	27.85	9.49	7	92325	57928	110439039
Blood magnesium increased	27.61	9.49	24	92308	3799	110493168
Abdominal discomfort	27.52	9.49	204	92128	393654	110103313
Psoriatic arthropathy	27.48	9.49	79	92253	196682	110300285
Drug-induced liver injury	27.40	9.49	36	92296	120031	110376936
Blood lactic acid increased	27.15	9.49	48	92284	15773	110481194
Lung hyperinflation	27.01	9.49	19	92313	2210	110494757
Drug interaction	27	9.49	277	92055	499906	109997061
Full blood count decreased	26.96	9.49	73	92259	32026	110464941
Oxygen saturation abnormal	26.75	9.49	28	92304	5583	110491384
Condition aggravated	26.75	9.49	442	91890	734394	109762573
Frequent bowel movements	26.46	9.49	124	92208	71266	110425701
Blood albumin decreased	26.42	9.49	66	92266	27586	110469381
Therapeutic response decreased	26.33	9.49	25	92307	96474	110400493
Status asthmaticus	26.04	9.49	14	92318	1007	110495960
Pleural effusion	25.80	9.49	244	92088	177465	110319502
Airway peak pressure increased	25.79	9.49	12	92320	633	110496334
Overdose	25.76	9.49	104	92228	233690	110263277
Blepharospasm	25.66	9.49	7	92325	54844	110442123
Device dislocation	25.53	9.49	71	92261	31633	110465334
Atelectasis	25.52	9.49	78	92254	36634	110460333
Pulmonary hypertension	25.12	9.49	102	92230	55118	110441849
Maternal exposure during delivery	24.99	9.49	22	92310	3543	110493424
Prescribed overdose	24.71	9.49	22	92310	87559	110409408
Hepatocellular injury	24.57	9.49	6	92326	50636	110446331
Electroencephalogram abnormal	24.55	9.49	28	92304	6145	110490822
Flushing	24.14	9.49	160	92172	104576	110392391
Night sweats	24.13	9.49	47	92285	133936	110363031
Cellulitis	23.54	9.49	183	92149	125833	110371134
Deep vein thrombosis postoperative	23.52	9.49	10	92322	59281	110437686
Aspartate aminotransferase increased	23.42	9.49	220	92112	159716	110337251
Haematocrit decreased	23.17	9.49	113	92219	66004	110430963
Failure to thrive	23.06	9.49	41	92291	13533	110483434
Liver disorder	23.02	9.49	53	92279	142190	110354777
Onychomadesis	22.97	9.49	5	92327	45658	110451309
Tachypnoea	22.26	9.49	78	92254	39317	110457650
Colitis ulcerative	22.14	9.49	125	92207	77238	110419729
Weight increased	21.98	9.49	234	92098	419410	110077557
Pulmonary fibrosis	21.88	9.49	32	92300	102010	110394957
Adjustment disorder with depressed mood	21.69	9.49	5	92327	43878	110453089
Unresponsive to stimuli	21.63	9.49	108	92224	63682	110433285
Dislocation of vertebra	21.57	9.49	5	92327	43716	110453251
Neuromuscular blockade	21.24	9.49	11	92321	733	110496234
Coeliac disease	21.18	9.49	5	92327	43182	110453785
Pantoea agglomerans infection	21.02	9.49	7	92325	149	110496818
Wound infection	20.93	9.49	30	92302	96435	110400532
Cardiac failure congestive	20.77	9.49	205	92127	150795	110346172
Sopor	20.56	9.49	3	92329	36543	110460424
Loss of personal independence in daily activities	20.39	9.49	61	92271	149959	110347008
Flatulence	20.38	9.49	92	92240	52057	110444910
Stomatitis	20.32	9.49	137	92195	270105	110226862
Urinary tract infection	20.32	9.49	384	91948	325898	110171069
Haematochezia	20.07	9.49	165	92167	115359	110381608
Onychomycosis	19.84	9.49	4	92328	38527	110458440
International normalised ratio increased	19.66	9.49	132	92200	86640	110410327
Dizziness	19.62	9.49	740	91592	697453	109799514
Metabolic encephalopathy	19.56	9.49	34	92298	11026	110485941
HELLP syndrome	19.55	9.49	11	92321	865	110496102
Transfusion	19.49	9.49	56	92276	25416	110471551
White blood cell count decreased	19.46	9.49	284	92048	229106	110267861
Red blood cell sedimentation rate increased	19.43	9.49	22	92310	78280	110418687
Infection	19.36	9.49	201	92131	361999	110134968
PO2 decreased	19.26	9.49	18	92314	3130	110493837
Pyrexia	19.17	9.49	925	91407	897340	109599627
Hospice care	19.07	9.49	36	92296	12437	110484530
Dyspnoea	19.06	9.49	1117	91215	1105755	109391212
Weight decreased	18.86	9.49	518	91814	467539	110029428
Infusion related reaction	18.59	9.49	216	92116	380946	110116021
Endometritis	18.47	9.49	11	92321	963	110496004
Pelvic pain	18.44	9.49	41	92291	15901	110481066
Bacteraemia	18.26	9.49	77	92255	42313	110454654
Nail bed tenderness	18.06	9.49	8	92324	376	110496591
Agranulocytosis	18.05	9.49	15	92317	61745	110435222
Feeling abnormal	17.88	9.49	230	92102	180481	110316486
Hypertension	17.50	9.49	310	92022	509774	109987193
Sleep disorder due to a general medical condition	17.39	9.49	11	92321	52101	110444866
Complication associated with device	17.21	9.49	46	92286	20027	110476940
Respiratory tract infection bacterial	17.11	9.49	15	92317	2401	110494566
Respiratory distress	16.96	9.49	107	92225	68767	110428200
Diabetes mellitus	16.93	9.49	36	92296	99345	110397622
Anxiety	16.87	9.49	392	91940	344686	110152281
Hyporeflexia	16.76	9.49	19	92313	4141	110492826
Renal failure	16.72	9.49	274	92058	226300	110270667
Coma	16.69	9.49	47	92285	117822	110379145
Autoimmune disorder	16.68	9.49	18	92314	65465	110431502
Small for dates baby	16.66	9.49	9	92323	653	110496314
Lethargy	16.44	9.49	134	92198	93442	110403525
Hypophagia	16.38	9.49	87	92245	52539	110444428
Product complaint	16.24	9.49	36	92296	13936	110483031
Back pain	15.91	9.49	414	91918	370582	110126385
Hepatitis	15.86	9.49	32	92300	90022	110406945
Cardiac arrest	15.67	9.49	241	92091	196512	110300455
Neuropathy peripheral	15.61	9.49	223	92109	179054	110317913
Sinus tachycardia	15.56	9.49	76	92256	44417	110452550
Taste disorder	15.55	9.49	19	92313	65368	110431599
Blood alkaline phosphatase increased	15.53	9.49	107	92225	70828	110426139
Urine output decreased	15.50	9.49	44	92288	19832	110477135
Drug reaction with eosinophilia and systemic symptoms	15.48	9.49	28	92304	82067	110414900
Adverse reaction	15.39	9.49	3	92329	29591	110467376
Anorgasmia	15.38	9.49	12	92320	1634	110495333
Dizziness postural	15.16	9.49	36	92296	14573	110482394
Painful ejaculation	15.12	9.49	5	92327	104	110496863
Therapy partial responder	15.10	9.49	6	92326	37055	110459912
Obstructive airways disorder	15.05	9.49	10	92322	46139	110450828
Cytomegalovirus infection	14.97	9.49	14	92318	54430	110442537
Product contamination microbial	14.85	9.49	10	92322	1084	110495883
Accidental exposure to product	14.80	9.49	12	92320	49996	110446971
Fatigue	14.74	9.49	1192	91140	1214766	109282201
Stillbirth	14.73	9.49	18	92314	4246	110492721
Antinuclear antibody positive	14.69	9.49	27	92305	9141	110487826
Pulmonary arterial hypertension	14.68	9.49	60	92272	32508	110464459
Bronchospasm	14.67	9.49	57	92275	30182	110466785
Vulvovaginal swelling	14.51	9.49	8	92324	605	110496362
Sciatica	14.49	9.49	35	92297	92364	110404603
Haemodynamic instability	14.41	9.49	47	92285	22841	110474126
Burkholderia test positive	14.37	9.49	8	92324	616	110496351
Vitamin B6 increased	14.29	9.49	4	92328	46	110496921
Multiple sclerosis relapse	14.26	9.49	81	92251	50159	110446808
Eczema	14.23	9.49	24	92308	72269	110424698
Laryngeal pain	14.18	9.49	21	92311	5954	110491013
Drug ineffective	14.14	9.49	1086	91246	1519454	108977513
Postpartum haemorrhage	13.93	9.49	12	92320	1877	110495090
Bone erosion	13.88	9.49	11	92321	46360	110450607
Blood culture positive	13.84	9.49	26	92306	8950	110488017
Blood calcium decreased	13.83	9.49	63	92269	35782	110461185
Incision site pain	13.81	9.49	15	92317	3120	110493847
Intentional self-injury	13.78	9.49	7	92325	37422	110459545
Hip fracture	13.72	9.49	62	92270	35089	110461878
Blood pressure fluctuation	13.69	9.49	26	92306	74798	110422169
Interstitial lung disease	13.51	9.49	65	92267	139269	110357698
Apnoea	13.50	9.49	33	92299	13606	110483361
Blood bilirubin increased	13.46	9.49	109	92223	75863	110421104
Mixed dementia	13.44	9.49	6	92326	287	110496680
Tachycardia	13.17	9.49	264	92068	226381	110270586
Dialysis	13.00	9.49	41	92291	19578	110477389
Seizure	12.97	9.49	258	92074	220927	110276040
Left ventricular dysfunction	12.83	9.49	46	92286	23447	110473520
X-ray abnormal	12.78	9.49	8	92324	38109	110458858
Dyspnoea exertional	12.75	9.49	138	92194	103922	110393045
Staphylococcal infection	12.74	9.49	101	92231	69843	110427124
Right ventricular failure	12.65	9.49	49	92283	25905	110471062
Influenza like illness	12.63	9.49	121	92211	88291	110408676
Skin discolouration	12.58	9.49	77	92255	48969	110447998
Tremor	12.57	9.49	238	92094	201994	110294973
Behaviour disorder	12.53	9.49	26	92306	9621	110487346
Hip arthroplasty	12.46	9.49	17	92315	55796	110441171
Osteonecrosis of jaw	12.45	9.49	13	92319	48004	110448963
Macroglossia	12.26	9.49	10	92322	1451	110495516
Cerebrovascular accident	12.20	9.49	216	92116	181068	110315899
Viral infection	12.13	9.49	81	92251	53058	110443909
Hypercapnia	12.13	9.49	28	92304	11131	110485836
Malnutrition	12.10	9.49	50	92282	27229	110469738
Ventricular extrasystoles	12.08	9.49	44	92288	22597	110474370
Decubitus ulcer	11.98	9.49	38	92294	18198	110478769
Pulmonary embolism	11.86	9.49	248	92084	214226	110282741
Blood pressure systolic increased	11.82	9.49	33	92299	82958	110414009
Septic shock	11.80	9.49	191	92141	157337	110339630
Gastrointestinal haemorrhage	11.78	9.49	199	92133	165319	110331648
Drug resistance	11.77	9.49	18	92314	56356	110440611
Pneumocystis jirovecii pneumonia	11.74	9.49	11	92321	42724	110454243
Acute pulmonary oedema	11.71	9.49	36	92296	16960	110480007
Lupus vulgaris	11.52	9.49	7	92325	33876	110463091
Knee arthroplasty	11.51	9.49	23	92309	64925	110432042
Ureteric stenosis	11.48	9.49	10	92322	1587	110495380
Dyspepsia	11.28	9.49	223	92109	190742	110306225
Impaired work ability	11.23	9.49	4	92328	26415	110470552
Rhabdomyolysis	11.20	9.49	57	92275	120344	110376623
Urticaria	11.17	9.49	193	92139	318664	110178303
Dysgeusia	11.12	9.49	98	92234	69887	110427080
Wound drainage	11.10	9.49	9	92323	1295	110495672
Road traffic accident	11.07	9.49	49	92283	107349	110389618
Testicular haemorrhage	11.03	9.49	5	92327	248	110496719
Adverse event	11.00	9.49	50	92282	108759	110388208
Negative pressure pulmonary oedema	10.98	9.49	7	92325	692	110496275
Splenic vein thrombosis	10.95	9.49	8	92324	987	110495980
Carbohydrate antigen 125 increased	10.89	9.49	12	92320	2535	110494432
Nervousness	10.85	9.49	60	92272	36791	110460176
Eosinophilia	10.71	9.49	20	92312	57916	110439051
C-reactive protein	10.69	9.49	6	92326	30325	110466642
Heparin-induced thrombocytopenia	10.64	9.49	27	92305	11397	110485570
Lupus-like syndrome	10.63	9.49	11	92321	40781	110456186
Foot deformity	10.59	9.49	15	92317	48465	110448502
Retinitis	10.55	9.49	7	92325	32320	110464647
Intestinal dilatation	10.49	9.49	14	92318	3606	110493361
Clostridium difficile infection	10.46	9.49	77	92255	52052	110444915
Muscle spasms	10.40	9.49	305	92027	277852	110219115
Drug tolerance decreased	10.37	9.49	5	92327	27535	110469432
Bradycardia foetal	10.36	9.49	4	92328	132	110496835
Prostatic pain	10.24	9.49	5	92327	294	110496673
Ear pain	10.18	9.49	18	92314	53208	110443759
Blood pressure diastolic decreased	10.14	9.49	9	92323	35876	110461091
Ventricular tachycardia	10.11	9.49	74	92258	49935	110447032
Aphasia	10.10	9.49	84	92248	58913	110438054
Product quality issue	10.10	9.49	32	92300	77267	110419700
Oesophagitis	10.01	9.49	49	92283	28666	110468301
Alanine aminotransferase increased	10.00	9.49	212	92120	183561	110313406
Liver function test increased	9.99	9.49	39	92293	88509	110408458
Sinusitis	9.94	9.49	181	92151	296507	110200460
Product contamination	9.86	9.49	10	92322	1921	110495046
Eye swelling	9.85	9.49	54	92278	32994	110463973
Pulse absent	9.81	9.49	26	92306	11266	110485701
Fluid retention	9.74	9.49	121	92211	94186	110402781
Finger deformity	9.72	9.49	8	92324	33084	110463883
Neoplasm progression	9.72	9.49	25	92307	64570	110432397
Biliary obstruction	9.71	9.49	17	92315	5541	110491426
Oedema peripheral	9.60	9.49	350	91982	328310	110168657
Computerised tomogram abnormal	9.58	9.49	14	92318	3922	110493045

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product preparation error	39.23	23.98	11	111	102	113729

Pharmacologic Action:

Source	Code	Description
ATC	A06AD04	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Osmotically acting laxatives
ATC	A12CC02	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Magnesium
ATC	B05XA05	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Electrolyte solutions
ATC	D11AX05	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
ATC	V04CC02	VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for bile duct patency
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D000700	Analgesics
MeSH PA	D000777	Anesthetics
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D012102	Reproductive Control Agents
MeSH PA	D015149	Tocolytic Agents
MeSH PA	D018689	Sensory System Agents
MeSH PA	D049990	Membrane Transport Modulators
CHEBI has role	CHEBI:50503	laxative
CHEBI has role	CHEBI:75325	cathartic
CHEBI has role	CHEBI:33287	fertilizer
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35623	anticonvulsant
CHEBI has role	CHEBI:38070	anti-arrhythmia drug
CHEBI has role	CHEBI:38215	calcium channel blocker
CHEBI has role	CHEBI:38867	anaesthetic
CHEBI has role	CHEBI:50247	antidote
CHEBI has role	CHEBI:63726	neuroprotective agent
CHEBI has role	CHEBI:65023	anti-asthmatic agent
CHEBI has role	CHEBI:66993	tocolytic agent
CHEBI has role	CHEBI:75835	anti-anaemic agent

Related Drugs by ATC class:

A06AD Osmotically acting laxatives 13 drugs

lactitol lactulose macrogol magnesium carbonate magnesium citrate magnesium oxide magnesium peroxide mannitol pentaerythritol sodium phosphate sodium sulfate sodium tartrate show all 13 →

A12CC Magnesium 9 drugs

magnesium aspartate magnesium chloride magnesium citrate magnesium gluconate magnesium lactate magnesium levulinate magnesium orotate magnesium oxide magnesium pidolate

B05XA Electrolyte solutions 18 drugs

ammonium chloride calcium chloride calcium gluconate hydrochloric acid magnesium chloride magnesium phosphate potassium acetate potassium chloride potassium lactate potassium phosphate sodium acetate sodium bicarbonate show all 18 →

D11AX Other dermatologicals 20 drugs

aminobenzoic acid brimonidine caffeine calcium gluconate deoxycholic acid diclofenac eflornithine finasteride gamolenic acid hydrogen peroxide hydroquinone ivermectin show all 20 →

V04CC Tests for bile duct patency 3 drugs

ceruletide sincalide sorbitol

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089
Mild pre-eclampsia	indication	41114007
Severe pre-eclampsia	indication	46764007
Hypomagnesemia	indication	190855004
Eclampsia in pregnancy	indication	198992004
Incomplete passage of stool	indication	249515001
Torsades de pointes	off-label use	31722008
Atypical Ventricular Tachycardia	off-label use
Hypocalcemia	contraindication	5291005
Hyperkalemia	contraindication	14140009
Complete atrioventricular block	contraindication	27885002
Dehydration	contraindication	34095006
Gastrointestinal ulcer	contraindication	40845000
Congenital myotonia, autosomal dominant form	contraindication	57938005
Acute nephropathy	contraindication	58574008
Hypermagnesemia	contraindication	66978005
Appendicitis	contraindication	74400008	DOID:8337
Kidney disease	contraindication	90708001	DOID:557
Gastrointestinal obstruction	contraindication	126765001
Gastroparesis	contraindication	235675006
Chronic diarrhea	contraindication	236071009
Hyporeninemic hypoaldosteronism	contraindication	236464008
Familial hyperkalemic periodic paralysis	contraindication	304737009	DOID:14451
Severe dehydration	contraindication	450316000

🐶 Veterinary Drug Use

Species	Use	Relation
Cattles	Used with sedative-relaxant and general anesthesia agents	Indication
Horses	Used with sedative-relaxant and general anesthesia agents	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Chloropent	Zoetis Inc.	3

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.225GM;0.188GM;1.479GM	SUTAB	AZURITY	N213135	Nov. 10, 2020	RX	TABLET	ORAL	11033498	Aug. 4, 2037	GASTROINTESTINAL TABLETS INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY
0.225GM;0.188GM;1.479GM	SUTAB	AZURITY	N213135	Nov. 10, 2020	RX	TABLET	ORAL	11382864	Aug. 4, 2037	GASTROINTESTINAL TABLETS INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY
0.9GM/BOT;178.7GM/BOT;1.12GM/BOT;0.5GM/BOT;7.3GM/BOT	SUFLAVE	AZURITY	N215344	June 15, 2023	RX	FOR SOLUTION	ORAL	12239659	June 14, 2044	GASTROINTESTINAL FLAVORED SOLUTION INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY
0.9GM/BOT;178.7GM/BOT;1.12GM/BOT;0.5GM/BOT;7.3GM/BOT	SUFLAVE	AZURITY	N215344	June 15, 2023	RX	FOR SOLUTION	ORAL	12433914	June 14, 2044	GASTROINTESTINAL FLAVORED SOLUTION INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
1GM/2ML (500MG/ML)	MAGNESIUM SULFATE	ASPIRO	A219777	May 28, 2025	RX	SOLUTION	INTRAMUSCULAR, INTRAVENOUS	Feb. 1, 2026	COMPETITIVE GENERIC THERAPY
25GM/50ML (500MG/ML)	MAGNESIUM SULFATE	ASPIRO	A219777	May 28, 2025	RX	SOLUTION	INTRAMUSCULAR, INTRAVENOUS	Feb. 1, 2026	COMPETITIVE GENERIC THERAPY
0.9GM/BOT;178.7GM/BOT;1.12GM/BOT;0.5GM/BOT;7.3GM/BOT	SUFLAVE	AZURITY	N215344	June 15, 2023	RX	FOR SOLUTION	ORAL	June 15, 2026	NEW PRODUCT
1.6GM/BOT;3.13GM/BOT;17.5GM/BOT	SUPREP BOWEL PREP KIT	AZURITY	N022372	Aug. 5, 2010	RX	SOLUTION	ORAL	Aug. 5, 2027	FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY IN PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER

Bioactivity Summary:

None

External reference:

ID	Source
4019181	VUID
N0000147424	NUI
10034-99-8	SECONDARY_CAS_RN
4000969	VANDF
4017468	VANDF
4017680	VANDF
4019181	VANDF
C0024480	UMLSCUI
CHEBI:32599	CHEBI
CHEMBL3989857	ChEMBL_ID
D008278	MESH_DESCRIPTOR_UI
DB00653	DRUGBANK_ID
24083	PUBCHEM_CID
1053346	RXNORM
173828	MMSL
173829	MMSL
26390	MMSL
36335	MMSL
5017	MMSL
5259	MMSL
6287	MMSL
7114	MMSL
d00468	MMSL
000789	NDDF
001184	NDDF
003022	NDDF
006708	NDDF
1269139001	SNOMEDCT_US
37400007	SNOMEDCT_US
387202002	SNOMEDCT_US
725797001	SNOMEDCT_US
CHEMBL2021423	ChEMBL_ID
SK47B8698T	UNII
SK47B8698T	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0264-4204	INJECTION, SOLUTION	2 g	INTRAVENOUS	ANDA	21 sections
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0264-4205	INJECTION, SOLUTION	4 g	INTRAVENOUS	ANDA	21 sections
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0264-4206	INJECTION, SOLUTION	4 g	INTRAVENOUS	ANDA	21 sections
Magnesium Sulfate in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0264-4400	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	26 sections
Magnesium Sulfate in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0264-4400	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	26 sections
TIS-U-SOL	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0190	IRRIGANT	20 mg	IRRIGATION	NDA	5 sections
TIS-U-SOL	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0190	IRRIGANT	20 mg	IRRIGATION	NDA	5 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0338-1708	INJECTION, SOLUTION	2 g	INTRAVENOUS	ANDA	20 sections
MAGNESIUM SULFATE IN DEXTROSE	HUMAN PRESCRIPTION DRUG LABEL	1	0338-1709	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	23 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0338-1715	INJECTION, SOLUTION	4 g	INTRAVENOUS	ANDA	20 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0338-1719	INJECTION, SOLUTION	4 g	INTRAVENOUS	ANDA	20 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0338-6353	INJECTION, SOLUTION	3 g	INTRAVENOUS	ANDA	20 sections
Epsom Salt	HUMAN OTC DRUG LABEL	1	0363-0395	GRANULE	1 g	ORAL	OTC Monograph Drug	15 sections
Epsom Salt	HUMAN OTC DRUG LABEL	1	0363-0942	GRANULE, FOR SOLUTION	1 g	ORAL	OTC Monograph Drug	15 sections
Humco Epson Salt	HUMAN OTC DRUG LABEL	1	0395-0807	POWDER, FOR SOLUTION	1000 mg	ORAL	OTC Monograph Drug	10 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9902	INJECTION, SOLUTION	500 mg	INTRAVENOUS	NDA	12 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9902	INJECTION, SOLUTION	500 mg	INTRAVENOUS	NDA	12 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9903	INJECTION, SOLUTION	500 mg	INTRAMUSCULAR	ANDA	12 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9903	INJECTION, SOLUTION	500 mg	INTRAMUSCULAR	ANDA	12 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9904	INJECTION, SOLUTION	500 mg	INTRAMUSCULAR	NDA	12 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9904	INJECTION, SOLUTION	500 mg	INTRAMUSCULAR	NDA	12 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1754	INJECTION, SOLUTION	500 mg	INTRAVENOUS	ANDA	13 sections
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2050	INJECTION, SOLUTION	20 g	INTRAVENOUS	NDA	19 sections
Magnesium Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0409-2168	INJECTION, SOLUTION	500 mg	INTRAVENOUS	ANDA	22 sections
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0409-3164	INJECTION, SOLUTION	40 g	INTRAVENOUS	NDA	19 sections
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0409-4121	INJECTION, SOLUTION	4 g	INTRAVENOUS	NDA	19 sections
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0409-5239	INJECTION, SOLUTION	2 g	INTRAVENOUS	NDA	19 sections
Magnesium Sulfate in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6727	INJECTION, SOLUTION	10 mg	INTRAVENOUS	NDA	26 sections
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6729	INJECTION, SOLUTION	40 mg	INTRAVENOUS	NDA	19 sections
Magnesium Sulfate in Water	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6730	INJECTION, SOLUTION	80 mg	INTRAVENOUS	NDA	19 sections

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magnesium sulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: