calcium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4479 7693-13-2

Description:

MoleculeDescription

Synonyms:

  • calcium citrate
A colorless crystalline or white powdery organic, tricarboxylic acid occurring in plants, especially citrus fruits, and used as a flavoring agent, as an antioxidant in foods, and as a sequestrating agent. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
  • Molecular weight: 498.43
  • Formula: C12H10Ca3O14
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 140.62
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 131.66 10.09 40 76677 287806 90263924
Drug ineffective 120.61 10.09 685 76032 1383613 89168117
Recalled product 102.29 10.09 40 76677 1348 90550382
Off label use 101.53 10.09 535 76182 1101717 89450013
Product use issue 92.23 10.09 86 76631 329833 90221897
Muscle spasms 84.45 10.09 429 76288 251454 90300276
Hypercholesterolaemia 75.60 10.09 222 76495 100670 90451060
Memory impairment 71.11 10.09 343 76374 196901 90354829
Drug interaction 70.48 10.09 78 76639 276375 90275355
Treatment failure 68.81 10.09 94 76623 303834 90247896
Contraindicated product administered 68.54 10.09 103 76614 320036 90231694
Intentional overdose 63.51 10.09 4 76713 93830 90457900
Onychomycosis 62.53 10.09 113 76604 37263 90514467
Wound infection 61.36 10.09 214 76503 106188 90445542
Grip strength decreased 61.22 10.09 195 76522 92381 90459349
Hypoaesthesia 60.44 10.09 464 76253 313746 90237984
Back injury 58.62 10.09 125 76592 46497 90505233
Product use in unapproved indication 58.60 10.09 123 76594 336113 90215617
Diarrhoea 56.13 10.09 1110 75607 938080 89613650
Joint dislocation 55.45 10.09 119 76598 44463 90507267
Breast cancer stage III 55.04 10.09 177 76540 84270 90467460
Fall 52.55 10.09 631 76086 481179 90070551
Liver function test increased 50.96 10.09 173 76544 84682 90467048
Depression 50.26 10.09 430 76287 300171 90251559
Blepharospasm 48.41 10.09 129 76588 55316 90496414
Seronegative arthritis 48.29 10.09 68 76649 18166 90533564
Drug intolerance 47.55 10.09 206 76511 447385 90104345
Dizziness 47.15 10.09 730 75987 588554 89963176
Product dose omission issue 47.06 10.09 414 76303 291273 90260457
Drug-induced liver injury 43.97 10.09 172 76545 90146 90461584
Maternal exposure during pregnancy 43.78 10.09 157 76560 359906 90191824
Walking aid user 43.27 10.09 94 76623 35412 90516318
Dyspepsia 42.85 10.09 301 76416 197859 90353871
Unevaluable event 42.33 10.09 122 76595 54726 90497004
Suicide attempt 41.38 10.09 7 76710 75392 90476338
Drug hypersensitivity 41.35 10.09 227 76490 463382 90088348
Osteoarthritis 40.98 10.09 295 76422 195435 90356295
Product label confusion 39.39 10.09 70 76647 22780 90528950
Therapeutic product effect decreased 39.34 10.09 113 76604 277458 90274272
Abdominal distension 37.97 10.09 214 76503 130387 90421343
Gait inability 37.44 10.09 232 76485 146224 90405506
Full blood count decreased 36.63 10.09 79 76638 29610 90522120
Anti-cyclic citrullinated peptide antibody 36.57 10.09 75 76642 27146 90524584
Joint stiffness 35.09 10.09 145 76572 77897 90473833
Joint range of motion decreased 34.75 10.09 215 76502 135428 90416302
Finger deformity 34.43 10.09 82 76635 32815 90518915
Injection site reaction 33.78 10.09 161 76556 91919 90459811
Psoriasis 33.44 10.09 227 76490 147527 90404203
Device expulsion 32.58 10.09 92 76625 40794 90510936
Taste disorder 31.42 10.09 119 76598 61427 90490303
Spinal fusion surgery 31.33 10.09 45 76672 12238 90539492
Adverse reaction 31.03 10.09 74 76643 29638 90522092
Headache 30.47 10.09 950 75767 861796 89689934
Flatulence 29.99 10.09 90 76627 41277 90510453
Onychomadesis 29.59 10.09 96 76621 45902 90505828
Fatigue 29.54 10.09 1225 75492 1152798 89398932
Hepatic enzyme 29.41 10.09 29 76688 5315 90546415
Nail disorder 29.16 10.09 113 76604 58954 90492776
Congenital anomaly 28.71 10.09 31 76686 6316 90545414
Injury 28.71 10.09 274 76443 197075 90354655
Gouty tophus 28.05 10.09 10 76707 259 90551471
Overdose 28.03 10.09 57 76660 157652 90394078
Obstructive defaecation 28.02 10.09 10 76707 260 90551470
COVID-19 27.55 10.09 64 76653 168779 90382951
Synovitis 27.47 10.09 165 76552 329587 90222143
Stoma site dermatitis 27.45 10.09 10 76707 276 90551454
Therapy cessation 27.21 10.09 80 76637 36281 90515449
Febrile neutropenia 26.66 10.09 59 76658 158290 90393440
Device dislocation 26.22 10.09 72 76645 31410 90520320
Coma 25.34 10.09 15 76702 72617 90479113
Spondylitis 25.17 10.09 44 76673 14134 90537596
Systemic lupus erythematosus 24.73 10.09 192 76525 361704 90190026
Intentional product misuse 24.25 10.09 24 76693 89580 90462150
Hepatic cirrhosis 24.22 10.09 112 76605 63141 90488589
Macular degeneration 24.20 10.09 79 76638 37891 90513839
Visual impairment 24.04 10.09 193 76524 132172 90419558
Prescribed underdose 23.86 10.09 126 76591 74893 90476837
Gastrointestinal stoma output abnormal 23.72 10.09 10 76707 410 90551320
Foetal exposure during pregnancy 23.55 10.09 4 76713 42971 90508759
Neuropathy peripheral 22.89 10.09 196 76521 136774 90414956
Osteoporosis 22.86 10.09 150 76567 96381 90455349
Osteocalcin decreased 22.78 10.09 6 76711 53 90551677
Premature delivery 22.64 10.09 3 76714 38759 90512971
Muscular weakness 22.61 10.09 271 76446 206395 90345335
Therapeutic product effect incomplete 22.59 10.09 86 76631 193810 90357920
Feeling abnormal 22.28 10.09 228 76489 167007 90384723
Thrombocytopenia 22.17 10.09 96 76621 208629 90343101
Hepatic function abnormal 21.93 10.09 6 76711 46282 90505448
Rhabdomyolysis 21.87 10.09 8 76709 51248 90500482
Bronchitis 21.58 10.09 211 76506 152716 90399014
Deep vein thrombosis 21.47 10.09 142 76575 91478 90460252
Dislocation of vertebra 21.36 10.09 99 76618 55869 90495861
Upper respiratory tract infection 21.11 10.09 183 76534 128135 90423595
Hot flush 21.08 10.09 103 76614 59385 90492345
Acute kidney injury 20.95 10.09 172 76545 320215 90231515
Plasma cell myeloma 20.89 10.09 79 76638 40749 90510981
Milk-alkali syndrome 20.45 10.09 13 76704 1260 90550470
Gastrooesophageal reflux disease 20.38 10.09 223 76494 166114 90385616
Multiple organ dysfunction syndrome 20.04 10.09 17 76700 68319 90483411
Pneumonia 20.00 10.09 693 76024 637366 89914364
Asthenia 19.65 10.09 591 76126 533160 90018570
Cardiac arrest 19.44 10.09 37 76680 104898 90446832
Coeliac disease 19.36 10.09 82 76635 44528 90507202
Blood pressure systolic increased 19.05 10.09 13 76704 58332 90493398
Fibromyalgia 18.98 10.09 262 76455 206007 90345723
Anaphylactic reaction 18.86 10.09 28 76689 87496 90464234
Ear infection 18.75 10.09 112 76605 69663 90482067
Blood cholesterol increased 18.65 10.09 263 76454 207749 90343981
Breast cancer stage I 18.58 10.09 31 76686 9593 90542137
Cholestasis 18.58 10.09 4 76713 36295 90515435
Pain in extremity 18.27 10.09 505 76212 450024 90101706
Lactic acidosis 18.20 10.09 10 76707 50453 90501277
Liver disorder 18.19 10.09 48 76669 121221 90430509
Exostosis 18.12 10.09 91 76626 53043 90498687
Drug eruption 17.92 10.09 4 76713 35403 90516327
Stoma site inflammation 17.91 10.09 10 76707 764 90550966
Electrocardiogram QT prolonged 17.84 10.09 21 76696 72435 90479295
Adjustment disorder with depressed mood 17.83 10.09 95 76622 56658 90495072
Therapy non-responder 17.68 10.09 58 76659 136646 90415084
Agranulocytosis 17.62 10.09 4 76713 34998 90516732
Lupus-like syndrome 17.61 10.09 85 76632 48761 90502969
Weight decreased 17.47 10.09 433 76284 379477 90172253
Laboratory test abnormal 17.44 10.09 76 76641 41778 90509952
Dry mouth 17.43 10.09 235 76482 183824 90367906
Lupus vulgaris 17.41 10.09 80 76637 44979 90506751
Laryngitis 17.36 10.09 87 76630 50666 90501064
Epilepsy 17.24 10.09 124 76593 82082 90469648
Altered state of consciousness 17.14 10.09 3 76714 31529 90520201
Normal newborn 17.10 10.09 51 76666 23311 90528419
Oedema peripheral 17.06 10.09 310 76407 257605 90294125
Retinitis 16.93 10.09 71 76646 38387 90513343
Product quality issue 16.84 10.09 120 76597 79205 90472525
Stoma site pain 16.84 10.09 12 76705 1405 90550325
Foot deformity 16.84 10.09 97 76620 59554 90492176
Faeces hard 16.75 10.09 17 76700 3225 90548505
Cardiac failure 16.68 10.09 43 76674 109453 90442277
Joint swelling 16.62 10.09 313 76404 502987 90048743
Pemphigus 16.48 10.09 187 76530 326677 90225053
Neck pain 16.45 10.09 158 76559 113805 90437925
Metabolic acidosis 16.14 10.09 14 76703 55662 90496068
Serotonin syndrome 16.02 10.09 6 76711 37881 90513849
Rheumatoid factor positive 15.85 10.09 83 76634 171567 90380163
Hyponatraemia 15.70 10.09 59 76658 133479 90418251
Hypocholesterolaemia 15.54 10.09 23 76694 6426 90545304
Therapeutic response decreased 15.46 10.09 33 76684 89696 90462034
Anxiety 15.43 10.09 357 76360 309415 90242315
Pain 15.24 10.09 689 76028 995652 89556078
Illness 15.10 10.09 29 76688 81940 90469790
Cardio-respiratory arrest 14.81 10.09 19 76698 63121 90488609
Hyperkalaemia 14.77 10.09 20 76697 64944 90486786
Pelvic pain 14.71 10.09 37 76680 15320 90536410
Hospice care 14.55 10.09 28 76689 9676 90542054
Respiratory arrest 14.55 10.09 5 76712 33306 90518424
Hip fracture 14.51 10.09 61 76656 33016 90518714
Blood potassium decreased 14.39 10.09 79 76638 47648 90504082
Drug resistance 14.33 10.09 4 76713 30445 90521285
Peripheral swelling 14.28 10.09 454 76263 412652 90139078
Depressed level of consciousness 14.07 10.09 25 76692 72759 90478971
Disability 14.05 10.09 70 76647 40675 90511055
Amnesia 14.00 10.09 147 76570 108358 90443372
Hepatotoxicity 13.94 10.09 11 76706 45831 90505899
Mucosal inflammation 13.87 10.09 17 76700 57608 90494122
Drug ineffective for unapproved indication 13.71 10.09 22 76695 66622 90485108
Restless legs syndrome 13.65 10.09 46 76671 22424 90529306
Intentional self-injury 13.53 10.09 4 76713 29330 90522400
Hypokalaemia 13.49 10.09 61 76656 131055 90420675
Cytomegalovirus infection 13.47 10.09 3 76714 26599 90525131
Defaecation urgency 13.26 10.09 21 76696 6221 90545509
Hip arthroplasty 13.23 10.09 110 76607 76098 90475632
Stress fracture 13.10 10.09 25 76692 8586 90543144
Gastrointestinal stoma complication 13.08 10.09 13 76704 2406 90549324
Gamma-glutamyltransferase increased 13.01 10.09 8 76709 37944 90513786
Eosinophilia 12.96 10.09 4 76713 28529 90523201
Paraesthesia 12.93 10.09 290 76427 250036 90301694
Bone erosion 12.92 10.09 83 76634 52938 90498792
Leukopenia 12.83 10.09 43 76674 100667 90451063
Diabetes mellitus 12.80 10.09 22 76695 64853 90486877
Angioedema 12.80 10.09 22 76695 64854 90486876
Nausea 12.78 10.09 1098 75619 1109218 89442512
Compression fracture 12.74 10.09 25 76692 8764 90542966
Body height decreased 12.73 10.09 30 76687 11919 90539811
Underweight 12.58 10.09 10 76707 1380 90550350
Exposure during pregnancy 12.56 10.09 135 76582 238275 90313455
Pancytopenia 12.35 10.09 56 76661 120207 90431523
Hiccups 12.34 10.09 14 76703 3012 90548718
Rash maculo-papular 12.23 10.09 10 76707 40923 90510807
Drug reaction with eosinophilia and systemic symptoms 12.10 10.09 11 76706 42747 90508983
Bradycardia 11.96 10.09 34 76683 83813 90467917
Mobility decreased 11.88 10.09 287 76430 250447 90301283
Accidental exposure to product 11.87 10.09 11 76706 42355 90509375
Lumbar vertebral fracture 11.78 10.09 22 76695 7436 90544294
Injection site haemorrhage 11.48 10.09 51 76666 28267 90523463
Sleep disorder due to general medical condition, insomnia type 11.45 10.09 63 76654 128631 90423099
Insomnia 11.39 10.09 366 76351 333108 90218622
Autoimmune disorder 10.87 10.09 106 76611 76638 90475092
Sedation 10.78 10.09 15 76702 48156 90503574
Bone marrow failure 10.76 10.09 7 76710 32214 90519516
Pyrexia 10.64 10.09 454 76263 660031 89891699
Gait disturbance 10.54 10.09 292 76425 260204 90291526
Eye swelling 10.50 10.09 51 76666 29335 90522395
Pulmonary arterial hypertension 10.49 10.09 47 76670 26140 90525590
Hepatic failure 10.34 10.09 11 76706 39717 90512013
Facet joint syndrome 10.31 10.09 128 76589 98261 90453469
Dry skin 10.29 10.09 117 76600 87956 90463774
C-reactive protein increased 10.28 10.09 213 76504 181176 90370554
Interstitial lung disease 10.17 10.09 32 76685 76373 90475357

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 123.65 12.26 132 26638 638203 41956362
Product use in unapproved indication 79.16 12.26 11 26759 184445 42410120
Fatigue 78.49 12.26 504 26266 435137 42159428
Plasma cell myeloma 62.05 12.26 109 26661 47469 42547096
Laboratory test abnormal 45.80 12.26 64 26706 22914 42571651
Full blood count decreased 45.12 12.26 60 26710 20500 42574065
Completed suicide 43.17 12.26 5 26765 96460 42498105
Diarrhoea 43.09 12.26 460 26310 460389 42134176
Product dose omission issue 42.70 12.26 201 26569 154164 42440401
Asthenia 42.12 12.26 311 26459 280482 42314083
Drug interaction 41.29 12.26 65 26705 266934 42327631
Toxicity to various agents 39.14 12.26 52 26718 229084 42365481
Fall 37.60 12.26 264 26506 234256 42360309
White blood cell count decreased 36.77 12.26 152 26618 110244 42484321
Drug ineffective 32.76 12.26 247 26523 629950 41964615
Adverse drug reaction 31.02 12.26 71 26699 37363 42557202
Thrombosis 30.88 12.26 104 26666 68407 42526158
Pneumonia 29.55 12.26 399 26371 421750 42172815
Mite allergy 27.77 12.26 24 26746 5022 42589543
Mycotic allergy 26.38 12.26 23 26747 4868 42589697
Intentional product misuse 25.81 12.26 4 26766 61896 42532669
Spirometry abnormal 25.37 12.26 23 26747 5123 42589442
Dust allergy 24.67 12.26 23 26747 5309 42589256
COVID-19 24.54 12.26 22 26748 115926 42478639
Psoriasis 23.89 12.26 76 26694 48528 42546037
Dizziness 23.26 12.26 249 26521 249005 42345560
Peripheral swelling 23.09 12.26 115 26655 90155 42504410
Conjunctivitis allergic 22.67 12.26 23 26747 5888 42588677
Influenza 22.59 12.26 88 26682 62087 42532478
Viral infection 22.46 12.26 46 26724 22437 42572128
General physical health deterioration 22.24 12.26 38 26732 151208 42443357
Neuropathy peripheral 20.80 12.26 122 26648 101731 42492834
Sinusitis 20.61 12.26 71 26699 47221 42547344
Febrile neutropenia 20.36 12.26 55 26715 185648 42408917
Interstitial lung disease 20.36 12.26 12 26758 78450 42516115
Treatment failure 20.27 12.26 7 26763 62617 42531948
Intentional product use issue 20.07 12.26 10 26760 71823 42522742
Muscle spasms 19.50 12.26 106 26664 85938 42508627
Memory impairment 19.00 12.26 72 26698 50150 42544415
Overdose 18.86 12.26 23 26747 105241 42489324
Multiple organ dysfunction syndrome 18.69 12.26 20 26750 97015 42497550
Hepatic function abnormal 18.06 12.26 5 26765 51562 42543003
Normochromic normocytic anaemia 17.76 12.26 25 26745 9006 42585559
Cardiac disorder 17.57 12.26 69 26701 48863 42545702
Coma 17.31 12.26 6 26764 53548 42541017
Small intestinal obstruction 17.15 12.26 35 26735 17026 42577539
Constipation 16.96 12.26 166 26604 162125 42432440
Dehydration 16.82 12.26 149 26621 141618 42452947
Cytokine release syndrome 16.20 12.26 4 26766 44523 42550042
Foetal exposure during pregnancy 15.82 12.26 5 26765 47306 42547259
Rash 15.10 12.26 251 26519 276703 42317862
Haemoglobin decreased 15.08 12.26 138 26632 132333 42462232
Influenza like illness 14.93 12.26 49 26721 31791 42562774
Flatulence 14.88 12.26 42 26728 25110 42569455
Unevaluable event 14.52 12.26 51 26719 34237 42560328
Hospice care 14.47 12.26 22 26748 8491 42586074
Back pain 14.32 12.26 144 26626 141632 42452933
Hip fracture 13.98 12.26 28 26742 13444 42581121
Drug ineffective for unapproved indication 13.55 12.26 6 26764 46157 42548408
Suicide attempt 13.52 12.26 6 26764 46094 42548471
Fluid retention 13.36 12.26 47 26723 31572 42562993
Mental status changes 13.23 12.26 57 26713 42058 42552507
Arteriosclerosis coronary artery 12.87 12.26 33 26737 18644 42575921
Leukopenia 12.70 12.26 17 26753 74729 42519836
Headache 12.69 12.26 216 26554 239153 42355412
Arteriosclerosis 12.62 12.26 32 26738 17957 42576608
Feeling abnormal 12.60 12.26 81 26689 69705 42524860

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 161.67 10.00 532 77405 1499653 109011709
Toxicity to various agents 146.58 10.00 78 77859 480477 110030885
Completed suicide 141.63 10.00 7 77930 242374 110268988
Drug interaction 110.18 10.00 114 77823 500069 110011293
Drug ineffective 99.83 10.00 646 77291 1519894 108991468
Fall 98.04 10.00 744 77193 602738 109908624
Muscle spasms 86.65 10.00 407 77530 277750 110233612
Product use in unapproved indication 81.57 10.00 118 77819 447259 110064103
Back injury 76.07 10.00 127 77810 47272 110464090
Product dose omission issue 76.06 10.00 436 77501 321346 110190016
Onychomycosis 72.49 10.00 111 77826 38420 110472942
Dizziness 71.02 10.00 778 77159 697415 109813947
Intentional overdose 70.96 10.00 6 77931 132495 110378867
Fatigue 66.97 10.00 1215 76722 1214743 109296619
Blepharospasm 65.17 10.00 129 77808 54722 110456640
Asthenia 62.97 10.00 752 77185 688247 109823115
Diarrhoea 58.67 10.00 1127 76810 1138378 109372984
Device expulsion 53.94 10.00 86 77851 30805 110480557
Plasma cell myeloma 52.06 10.00 128 77809 62808 110448554
Memory impairment 51.95 10.00 275 77662 196669 110314693
Product label confusion 50.88 10.00 71 77866 22606 110488756
Intentional product misuse 49.43 10.00 16 77921 132888 110378474
Abdominal distension 44.48 10.00 242 77695 174861 110336501
Finger deformity 44.45 10.00 82 77855 33010 110478352
Product use issue 44.30 10.00 96 77841 311599 110199763
COVID-19 44.26 10.00 65 77872 244995 110266367
Depression 43.14 10.00 376 77561 316959 110194403
Injection site reaction 42.62 10.00 149 77788 88921 110422441
Onychomadesis 42.23 10.00 97 77840 45566 110465796
Nail disorder 41.88 10.00 112 77825 57823 110453539
Suicide attempt 41.09 10.00 11 77926 103383 110407979
Coma 40.74 10.00 16 77921 117853 110393509
Headache 40.08 10.00 857 77080 881520 109629842
Full blood count decreased 38.74 10.00 76 77861 32023 110479339
Breast cancer stage III 37.55 10.00 132 77805 78985 110432377
Taste disorder 37.20 10.00 116 77821 65271 110446091
Hepatic enzyme 36.93 10.00 30 77907 5133 110506229
Adverse reaction 36.85 10.00 71 77866 29523 110481839
Febrile neutropenia 36.18 10.00 109 77828 316658 110194704
Therapy cessation 35.80 10.00 90 77847 44767 110466595
Treatment failure 35.69 10.00 90 77847 277144 110234218
Deep vein thrombosis 33.96 10.00 191 77746 139696 110371666
Recalled product 33.92 10.00 16 77921 1034 110510328
Rheumatoid factor positive 33.73 10.00 26 77911 131614 110379748
Cytokine release syndrome 33.09 10.00 5 77932 70301 110441061
Multiple organ dysfunction syndrome 32.87 10.00 35 77902 151675 110359687
Hepatic function abnormal 32.76 10.00 11 77926 89284 110422078
Overdose 32.39 10.00 73 77864 233721 110277641
Dyspepsia 31.20 10.00 236 77701 190729 110320633
Hospice care 30.93 10.00 41 77896 12432 110498930
Product quality issue 30.87 10.00 122 77815 77177 110434185
Feeling abnormal 30.47 10.00 225 77712 180486 110330876
Flatulence 30.12 10.00 93 77844 52056 110459306
Obstructive defaecation 30.10 10.00 10 77927 252 110511110
Device dislocation 30.04 10.00 68 77869 31636 110479726
Eosinophilia 30.01 10.00 3 77934 57933 110453429
Coeliac disease 29.72 10.00 82 77855 43105 110468257
Dry mouth 29.31 10.00 241 77696 199707 110311655
Unevaluable event 29.13 10.00 100 77837 59127 110452235
Stoma site dermatitis 28.81 10.00 10 77927 289 110511073
Gastrooesophageal reflux disease 28.05 10.00 220 77717 179756 110331606
Hip fracture 27.50 10.00 70 77867 35081 110476281
Cholestasis 27.33 10.00 6 77931 64512 110446850
Dehydration 27.18 10.00 309 77628 279202 110232160
Pneumonia 26.88 10.00 808 77129 875906 109635456
Infection 26.66 10.00 148 77789 362052 110149310
Normal newborn 26.61 10.00 52 77885 21844 110489518
Rhabdomyolysis 25.83 10.00 28 77909 120373 110390989
Agranulocytosis 25.65 10.00 6 77931 61754 110449608
Gastrointestinal stoma output abnormal 25.22 10.00 10 77927 422 110510940
Synovitis 24.82 10.00 104 77833 273988 110237374
Drug resistance 24.37 10.00 5 77932 56369 110454993
Mite allergy 24.35 10.00 25 77912 5778 110505584
Osteocalcin decreased 24.29 10.00 6 77931 49 110511313
Gouty tophus 23.99 10.00 10 77927 481 110510881
Spirometry abnormal 23.65 10.00 24 77913 5473 110505889
Hypoaesthesia 23.57 10.00 331 77606 313892 110197470
Cytomegalovirus infection 23.19 10.00 5 77932 54439 110456923
Fluid retention 23.04 10.00 129 77808 94178 110417184
Facet joint syndrome 22.70 10.00 131 77806 96697 110414665
Drug reaction with eosinophilia and systemic symptoms 22.62 10.00 15 77922 82080 110429282
Therapeutic response decreased 22.34 10.00 21 77916 96478 110414884
Neck pain 22.31 10.00 156 77781 122974 110388388
Nausea 22.10 10.00 1073 76864 1234617 109276745
Migraine 22.07 10.00 201 77736 171451 110339911
Mycotic allergy 22.05 10.00 24 77913 5930 110505432
Drug ineffective for unapproved indication 21.97 10.00 24 77913 102814 110408548
Dust allergy 21.90 10.00 24 77913 5977 110505385
Milk-alkali syndrome 21.85 10.00 15 77922 1990 110509372
Wound infection 21.64 10.00 129 77808 96336 110415026
Haemoglobin decreased 21.55 10.00 269 77668 248458 110262904
Anaphylactic shock 21.42 10.00 5 77932 51541 110459821
Altered state of consciousness 21.31 10.00 7 77930 57619 110453743
Cardiac failure 21.10 10.00 65 77872 187561 110323801
Acute kidney injury 21.06 10.00 318 77619 635112 109876250
Peripheral swelling 20.78 10.00 400 77537 403634 110107728
Lactic acidosis 20.56 10.00 21 77916 92790 110418572
Interstitial lung disease 20.55 10.00 42 77895 139292 110372070
Hypervolaemia 20.51 10.00 79 77858 49381 110461981
Depressed level of consciousness 20.05 10.00 30 77907 112248 110399114
Pain in extremity 19.80 10.00 466 77471 486652 110024710
Swollen joint count increased 19.61 10.00 18 77919 83643 110427719
Epilepsy 19.36 10.00 129 77808 100080 110411282
Blood pressure systolic increased 19.29 10.00 18 77919 82973 110428389
Conjunctivitis allergic 19.09 10.00 24 77913 6907 110504455
Hypocholesterolaemia 18.92 10.00 23 77914 6398 110504964
Contraindicated product administered 18.50 10.00 101 77836 248166 110263196
Grip strength decreased 18.49 10.00 108 77829 80066 110431296
Drug hypersensitivity 18.40 10.00 218 77719 453872 110057490
Pelvic pain 18.34 10.00 37 77900 15905 110495457
Osteoarthritis 18.25 10.00 203 77734 182420 110328942
Gait inability 18.20 10.00 161 77776 136215 110375147
Blood potassium decreased 18.16 10.00 81 77856 54033 110457329
Cardio-respiratory arrest 17.87 10.00 34 77903 115802 110395560
Drug intolerance 17.71 10.00 192 77745 406320 110105042
Stoma site pain 17.51 10.00 13 77924 1950 110509412
Musculoskeletal pain 17.18 10.00 201 77736 182822 110328540
Leukopenia 17.12 10.00 51 77886 148740 110362622
Liver function test increased 17.11 10.00 114 77823 88434 110422928
Accidental exposure to product 16.93 10.00 7 77930 50001 110461361
Liver disorder 16.91 10.00 48 77889 142195 110369167
Stoma site inflammation 16.91 10.00 10 77927 1025 110510337
Pulmonary arterial hypertension 16.91 10.00 56 77881 32512 110478850
Paraesthesia 16.77 10.00 281 77656 276240 110235122
Hot flush 16.57 10.00 91 77846 65945 110445417
Insomnia 16.55 10.00 351 77586 360239 110151123
Cardiogenic shock 16.45 10.00 10 77927 57328 110454034
Thrombocytopenia 16.33 10.00 162 77775 348723 110162639
Sedation 16.33 10.00 15 77922 69668 110441694
Multiple sclerosis relapse 15.97 10.00 74 77863 50166 110461196
Viral infection 15.96 10.00 77 77860 53062 110458300
Hospitalisation 15.92 10.00 162 77775 142331 110369031
Neurotoxicity 15.83 10.00 5 77932 42202 110469160
Hypoxia 15.81 10.00 150 77787 129365 110381997
Dyspnoea 15.73 10.00 941 76996 1105931 109405431
Underweight 15.63 10.00 11 77926 1519 110509843
Small intestinal obstruction 15.50 10.00 54 77883 32159 110479203
Peripheral venous disease 15.48 10.00 107 77830 84010 110427352
Diabetes mellitus 15.48 10.00 29 77908 99352 110412010
Influenza like illness 15.42 10.00 111 77826 88301 110423061
Gastrointestinal stoma complication 15.33 10.00 15 77922 3274 110508088
Mental status changes 15.32 10.00 99 77838 76023 110435339
Cardiac arrest 15.24 10.00 79 77858 196674 110314688
Blood cholesterol increased 15.22 10.00 198 77739 184587 110326775
Bursitis 15.14 10.00 149 77788 129769 110381593
Rash maculo-papular 15.11 10.00 18 77919 74204 110437158
Electrocardiogram QT prolonged 15.10 10.00 34 77903 108926 110402436
Neuritis 14.89 10.00 22 77915 7377 110503985
Back pain 14.78 10.00 354 77583 370642 110140720
Anaphylactic reaction 14.78 10.00 37 77900 114263 110397099
Metabolic acidosis 14.76 10.00 30 77907 99714 110411648
Serotonin syndrome 14.75 10.00 12 77925 59141 110452221
Eye swelling 14.71 10.00 54 77883 32994 110478368
White blood cell count decreased 14.61 10.00 235 77702 229155 110282207
Gamma-glutamyltransferase increased 14.60 10.00 13 77924 61296 110450066
Bone pain 14.54 10.00 87 77850 65046 110446316
Drug eruption 14.52 10.00 10 77927 53649 110457713
Shock 14.48 10.00 10 77927 53578 110457784
Renal impairment 14.41 10.00 76 77861 188369 110322993
Thrombosis 14.35 10.00 128 77809 108534 110402828
Infective pulmonary exacerbation of cystic fibrosis 14.35 10.00 32 77905 14739 110496623
Haematocrit decreased 13.93 10.00 87 77850 66030 110445332
Illness 13.68 10.00 23 77914 82148 110429214
Ventricular fibrillation 13.64 10.00 6 77931 41307 110470055
Disseminated intravascular coagulation 13.63 10.00 6 77931 41280 110470082
Polyneuropathy 13.51 10.00 3 77934 32009 110479353
Muscular weakness 13.45 10.00 248 77689 248220 110263142
Angioedema 13.44 10.00 31 77906 98469 110412893
Red blood cell count decreased 13.43 10.00 86 77851 65837 110445525
Mucosal inflammation 13.32 10.00 30 77907 96111 110415251
Circulatory collapse 13.05 10.00 7 77930 42986 110468376
General physical health deterioration 13.01 10.00 216 77721 425079 110086283
Injection site erythema 12.99 10.00 112 77825 94064 110417298
Bone marrow failure 12.92 10.00 13 77924 57835 110453527
Pneumocystis jirovecii pneumonia 12.91 10.00 7 77930 42728 110468634
Hyponatraemia 12.90 10.00 95 77842 217558 110293804
Weight decreased 12.88 10.00 426 77511 467631 110043731
Neutropenic sepsis 12.74 10.00 3 77934 30743 110480619
Complication associated with device 12.72 10.00 37 77900 20036 110491326
Premature delivery 12.67 10.00 3 77934 30629 110480733
Hypokalaemia 12.64 10.00 76 77861 182372 110328990
Pain in jaw 12.49 10.00 70 77867 51107 110460255
Pulmonary hypertension 12.48 10.00 74 77863 55146 110456216
Dyspnoea exertional 12.44 10.00 120 77817 103940 110407422
Compression fracture 12.43 10.00 23 77914 9276 110502086
Normochromic normocytic anaemia 12.36 10.00 28 77909 13029 110498333
Urinary tract infection 12.30 10.00 309 77628 325973 110185389
Bradycardia 12.29 10.00 62 77875 155455 110355907
Injection site haemorrhage 12.29 10.00 51 77886 32977 110478385
Dysgeusia 12.28 10.00 88 77849 69897 110441465
Asthma 12.22 10.00 115 77822 250176 110261186
Injury 12.20 10.00 184 77753 177081 110334281
Heavy menstrual bleeding 12.19 10.00 32 77905 16333 110495029
Anxiety 12.19 10.00 324 77613 344754 110166608
Faeces hard 12.17 10.00 15 77922 4231 110507131
Nasal congestion 12.08 10.00 114 77823 98168 110413194
Eructation 12.06 10.00 29 77908 14028 110497334
Hyperkalaemia 11.99 10.00 52 77885 135744 110375618
Pulmonary embolism 11.94 10.00 215 77722 214259 110297103
Acute respiratory distress syndrome 11.83 10.00 12 77925 53186 110458176
Spinal fracture 11.82 10.00 39 77898 22594 110488768
Thrombotic microangiopathy 11.77 10.00 3 77934 29146 110482216
Rotator cuff syndrome 11.67 10.00 32 77905 16762 110494600
Respiratory depression 11.64 10.00 4 77933 31997 110479365
Hiccups 11.53 10.00 27 77910 12842 110498520
Intentional self-injury 11.50 10.00 6 77931 37423 110473939
Cardiac failure congestive 11.28 10.00 159 77778 150841 110360521
Hepatotoxicity 11.26 10.00 17 77920 63383 110447979
Septic shock 11.24 10.00 65 77872 157463 110353899
Red blood cell sedimentation rate increased 11.21 10.00 24 77913 78278 110433084
Vaginal haemorrhage 11.18 10.00 41 77896 25033 110486329
Neuroleptic malignant syndrome 11.16 10.00 5 77932 34054 110477308
Stress fracture 11.12 10.00 19 77918 7202 110504160
Product complaint 11.11 10.00 28 77909 13944 110497418
Joint swelling 11.04 10.00 233 77704 442612 110068750
Macular degeneration 11.03 10.00 37 77900 21622 110489740
Respiratory arrest 10.98 10.00 15 77922 58284 110453078
Acute hepatic failure 10.98 10.00 6 77931 36462 110474900
Product prescribing error 10.94 10.00 12 77925 51319 110460043
Laryngeal pain 10.94 10.00 17 77920 5958 110505404
Defaecation urgency 10.91 10.00 21 77916 8726 110502636
Intentional product use issue 10.82 10.00 117 77820 247789 110263573
Restless legs syndrome 10.76 10.00 40 77897 24586 110486776
Constipation 10.71 10.00 329 77608 357457 110153905
Arteriosclerosis 10.63 10.00 40 77897 24727 110486635
Fibromyalgia 10.47 10.00 174 77763 170735 110340627
Ulcer 10.44 10.00 9 77928 43107 110468255
Bronchopulmonary aspergillosis 10.41 10.00 4 77933 29859 110481503
Lethargy 10.26 10.00 106 77831 93470 110417892
Hypersomnia 10.18 10.00 43 77894 28018 110483344
Cerebral infarction 10.10 10.00 13 77924 51825 110459537

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A12AA13 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
CALCIUM
Calcium
MeSH PA D005503 Food Additives
CHEBI has role CHEBI:35617 flavouring agent
CHEBI has role CHEBI:50733 nutraceutical
CHEBI has role CHEBI:64047 food additive
CHEBI has role CHEBI:65255 food preservative

Related Drugs by ATC class:

A12AA Calcium 11 drugs
calcium carbonatecalcium chloridecalcium glubionatecalcium glucoheptonatecalcium gluconatecalcium glycerylphosphatecalcium lactatecalcium lactate gluconatecalcium levulinatecalcium pangamatecalcium phosphate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Diarrhea contraindication 62315008
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypercalciuria contraindication 71938000
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00933 KEGG_DRUG
4019484 VUID
N0000147604 NUI
5785-44-4 SECONDARY_CAS_RN
4019479 VANDF
4019484 VANDF
CHEMBL2106123 ChEMBL_ID
DB11093 DRUGBANK_ID
47613 RXNORM
16535 MMSL
4334 MMSL
6782 MMSL
d03866 MMSL
003645 NDDF
C0108101 UMLSCUI
D019355 MESH_DESCRIPTOR_UI
13136 PUBCHEM_CID
MLM29U2X85 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Citranatal Harmony 2.1 HUMAN PRESCRIPTION DRUG LABEL 2 0178-0797 CAPSULE, GELATIN COATED 104 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 104 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 100 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 100 mg ORAL Unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 159 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 160 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 124 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 125 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 125 mg ORAL Unapproved drug other 11 sections
LiquiCal Plus HUMAN PRESCRIPTION DRUG LABEL 4 59088-201 LIQUID 252 mg ORAL unapproved drug other 10 sections
Livita Adults HUMAN PRESCRIPTION DRUG LABEL 17 59088-659 LIQUID 200 mg ORAL unapproved drug other 10 sections
Livita Children HUMAN PRESCRIPTION DRUG LABEL 17 59088-660 LIQUID 66.67 mg ORAL unapproved drug other 10 sections
Folcyteine HUMAN PRESCRIPTION DRUG LABEL 5 59088-795 TABLET 47 mg ORAL unapproved drug other 11 sections
INATAL Ultra HUMAN PRESCRIPTION DRUG LABEL 16 63044-154 TABLET, COATED 200 mg ORAL Unapproved drug other 10 sections
Matervia HUMAN PRESCRIPTION DRUG LABEL 9 72835-660 CAPSULE 200 mg ORAL unapproved drug other 7 sections