caffeine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
463 58-08-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anhydrous caffeine
  • peyona
  • caffeine
  • 1,3,7-trimethyl-2,6-dioxopurine
  • 7-methyltheophylline
  • cafalgine
  • cafeina
  • durvitan
  • guaranine
  • thein
  • caffeine citrate
  • caffeine, citrated
  • nymusa
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
  • Molecular weight: 194.19
  • Formula: C8H10N4O2
  • CLOGP: -0.04
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 58.44
  • ALOGS: -1.25
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 21.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 51.77 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.63 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.64 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.90 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,JAK1,MAP3K21,MAPK7,MARK4,MET,MTOR,NTRK2,PDK2,PIK3CD,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,ULK1 32
kinase-selectivity-class CDK9,GRK2,IRAK1,PRKDC 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.630 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.918 % High 1

Approvals:

DateAgencyCompanyOrphan
Nov. 26, 1948 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid factor positive 649.96 16.11 1091 151395 170559 90305402
Duodenal ulcer perforation 573.08 16.11 1195 151291 220093 90255868
Helicobacter infection 567.70 16.11 1208 151278 225642 90250319
Swollen joint count increased 543.41 16.11 795 151691 110411 90365550
Injury 541.96 16.11 1092 151394 196257 90279704
Deep vein thrombosis postoperative 529.23 16.11 624 151862 70185 90405776
Anti-cyclic citrullinated peptide antibody positive 523.75 16.11 1199 151287 235234 90240727
Rheumatic fever 517.77 16.11 926 151560 152195 90323766
Liver injury 515.83 16.11 983 151503 169584 90306377
Blood cholesterol increased 513.82 16.11 1102 151384 206910 90269051
Autoimmune disorder 495.29 16.11 628 151858 76116 90399845
Pericarditis 487.51 16.11 1266 151220 268885 90207076
Type 2 diabetes mellitus 451.42 16.11 1032 151454 202212 90273749
Fibromyalgia 448.93 16.11 1039 151447 205230 90270731
Discomfort 446.97 16.11 1238 151248 273097 90202864
Hand deformity 420.73 16.11 1273 151213 295089 90180872
Mobility decreased 414.83 16.11 1138 151348 249596 90226365
Lower limb fracture 408.33 16.11 603 151883 84410 90391551
Muscle injury 407.83 16.11 911 151575 175743 90300218
Folliculitis 403.24 16.11 991 151495 203362 90272599
Blister 386.25 16.11 1121 151365 253877 90222084
Psoriatic arthropathy 385.30 16.11 1044 151442 227291 90248670
Pemphigus 356.42 16.11 1284 151202 325580 90150381
Adjustment disorder with depressed mood 348.18 16.11 453 152033 56300 90419661
Cough 346.50 16.11 96 152390 368866 90107095
Product dose omission issue 341.31 16.11 44 152442 291643 90184318
Road traffic accident 338.45 16.11 631 151855 106995 90368966
Glossodynia 335.61 16.11 1246 151240 320533 90155428
Hepatic enzyme increased 333.96 16.11 1345 151141 359391 90116570
Anaemia 329.04 16.11 93 152393 352709 90123252
Sleep disorder due to general medical condition, insomnia type 328.11 16.11 691 151795 128003 90347958
C-reactive protein abnormal 324.63 16.11 684 151802 126745 90349216
Oedema 317.20 16.11 895 151591 199400 90276561
Wound 315.74 16.11 1173 151313 301807 90174154
Irritable bowel syndrome 313.05 16.11 911 151575 206537 90269424
Acute kidney injury 312.92 16.11 77 152409 320310 90155651
Lupus vulgaris 303.81 16.11 377 152109 44682 90431279
Synovitis 300.77 16.11 1224 151262 328528 90147433
Lip dry 295.33 16.11 574 151912 100381 90375580
Urinary tract infection 286.01 16.11 80 152406 305552 90170409
Impaired healing 282.82 16.11 952 151534 233247 90242714
Sciatica 282.75 16.11 565 151921 100817 90375144
Arthropathy 281.51 16.11 1291 151195 364951 90111010
Joint range of motion decreased 278.26 16.11 668 151818 134975 90340986
Lower respiratory tract infection 275.01 16.11 987 151499 249672 90226289
Dislocation of vertebra 271.58 16.11 399 152087 55569 90420392
Hypercholesterolaemia 271.52 16.11 554 151932 100338 90375623
X-ray abnormal 271.51 16.11 358 152128 45066 90430895
Gait inability 260.34 16.11 683 151803 145773 90330188
General physical health deterioration 254.73 16.11 1227 151259 353888 90122073
Pulmonary fibrosis 253.08 16.11 559 151927 106944 90369017
Systemic lupus erythematosus 251.40 16.11 1239 151247 360657 90115304
Musculoskeletal stiffness 244.07 16.11 1067 151419 295465 90180496
Neutropenia 242.26 16.11 43 152443 224861 90251100
Prescribed overdose 233.60 16.11 511 151975 97114 90378847
Liver disorder 228.35 16.11 578 151908 120691 90355270
Ill-defined disorder 222.61 16.11 751 151735 184140 90291821
Fall 219.35 16.11 294 152192 481516 89994445
Stomatitis 215.11 16.11 974 151512 273724 90202237
Peripheral venous disease 210.78 16.11 448 152038 83473 90392488
Contusion 209.74 16.11 908 151578 250308 90225653
Grip strength decreased 208.48 16.11 473 152013 92103 90383858
Hypoaesthesia 207.70 16.11 1061 151425 313149 90162812
Bursitis 206.03 16.11 586 151900 131068 90344893
Erythema 200.03 16.11 68 152418 229178 90246783
Night sweats 197.48 16.11 569 151917 128197 90347764
Drug ineffective 196.43 16.11 1446 151040 1382852 89093109
COVID-19 193.76 16.11 27 152459 168816 90307145
Death 193.51 16.11 293 152193 456258 90019703
Delirium 192.91 16.11 494 151992 103865 90372096
Infusion related reaction 190.78 16.11 1277 151209 415503 90060458
Sepsis 188.03 16.11 37 152449 179777 90296184
C-reactive protein 185.56 16.11 246 152240 31121 90444840
Ulcer haemorrhage 185.12 16.11 225 152261 26096 90449865
Disease progression 184.61 16.11 23 152463 156592 90319369
Rheumatoid arthritis 181.82 16.11 1137 151349 361477 90114484
Neuropathy peripheral 177.40 16.11 14 152472 136956 90339005
Injection site pain 174.92 16.11 39 152447 173660 90302301
Blood pressure increased 174.67 16.11 57 152429 197160 90278801
Facet joint syndrome 172.88 16.11 457 152029 97932 90378029
Hip arthroplasty 171.16 16.11 389 152097 75819 90400142
Breast cancer stage II 168.65 16.11 250 152236 35084 90440877
Sleep disorder 166.15 16.11 717 151769 197313 90278648
Hypotension 165.49 16.11 182 152304 325215 90150746
Amnesia 164.93 16.11 478 152008 108027 90367934
Swelling 159.87 16.11 1229 151257 417829 90058132
Gastrointestinal disorder 157.98 16.11 850 151636 255837 90220124
Osteoarthritis 157.60 16.11 700 151786 195030 90280931
Urticaria 156.32 16.11 980 151506 311754 90164207
Retinitis 155.43 16.11 252 152234 38206 90437755
Myalgia 152.65 16.11 52 152434 175073 90300888
Lung disorder 150.62 16.11 574 151912 149309 90326652
Abdominal discomfort 149.53 16.11 1339 151147 475989 89999972
Adverse event 149.31 16.11 486 152000 116932 90359029
Abdominal pain upper 148.93 16.11 1014 151472 331660 90144301
Pancytopenia 148.43 16.11 15 152471 120248 90355713
Febrile neutropenia 147.00 16.11 42 152444 158307 90317654
Alopecia 146.59 16.11 1372 151114 493699 89982262
Wheezing 146.22 16.11 788 151698 237292 90238669
Pregnancy 145.24 16.11 322 152164 61725 90414236
Anti-cyclic citrullinated peptide antibody 145.13 16.11 203 152283 27018 90448943
Wound infection 142.20 16.11 448 152038 105954 90370007
Dry mouth 141.99 16.11 650 151836 183409 90292552
White blood cell count decreased 141.58 16.11 52 152434 167057 90308904
Walking aid user 141.24 16.11 231 152255 35275 90440686
Influenza 140.75 16.11 31 152455 139233 90336728
Grip strength 139.85 16.11 118 152368 8847 90467114
Bone erosion 138.87 16.11 288 152198 52733 90423228
Breast cancer stage III 138.07 16.11 382 152104 84065 90391896
Hypersensitivity 137.05 16.11 1265 151221 453412 90022549
Obesity 136.22 16.11 439 152047 105068 90370893
Exostosis 134.95 16.11 285 152201 52849 90423112
Platelet count decreased 133.45 16.11 33 152453 136936 90339025
Knee arthroplasty 132.77 16.11 373 152113 82809 90393152
Confusional state 131.63 16.11 1104 151382 385101 90090860
Back pain 130.97 16.11 207 152279 316968 90158993
Porphyria acute 128.59 16.11 155 152331 17820 90458141
Musculoskeletal pain 127.82 16.11 599 151887 170652 90305309
Inappropriate schedule of product administration 126.43 16.11 47 152439 149886 90326075
Cardiac failure 124.46 16.11 18 152468 109478 90366483
Subcutaneous drug absorption impaired 124.45 16.11 133 152353 13412 90462549
Dehydration 123.80 16.11 88 152398 194359 90281602
Treatment failure 121.21 16.11 901 151585 303027 90172934
Malignant neoplasm progression 120.47 16.11 18 152468 106852 90369109
Maternal exposure timing unspecified 120.36 16.11 168 152318 22315 90453646
Therapy non-responder 120.05 16.11 502 151984 136202 90339759
Disability 119.47 16.11 232 152254 40513 90435448
Off label use 118.31 16.11 1236 151250 1101016 89374945
Illness 116.39 16.11 5 152481 81964 90393997
Oropharyngeal pain 115.67 16.11 26 152460 115161 90360800
Alanine aminotransferase increased 114.33 16.11 29 152457 118309 90357652
Intentional product use issue 114.16 16.11 689 151797 216203 90259758
Renal impairment 113.81 16.11 20 152466 105401 90370560
Dyspepsia 113.69 16.11 644 151842 197516 90278445
Migraine 113.37 16.11 625 151861 189767 90286194
Haemoglobin decreased 113.05 16.11 66 152420 161890 90314071
Decreased appetite 112.57 16.11 1046 151440 375494 90100467
Pleural effusion 109.06 16.11 27 152459 111964 90363997
Herpes zoster 108.88 16.11 15 152471 94629 90381332
Joint swelling 107.76 16.11 1307 151179 501993 89973968
Constipation 107.42 16.11 192 152294 280203 90195758
General symptom 107.41 16.11 128 152358 14540 90461421
Nasal congestion 106.68 16.11 9 152477 83405 90392556
Laryngitis 106.19 16.11 252 152234 50501 90425460
Cardiac failure congestive 105.94 16.11 19 152467 98675 90377286
Nausea 105.34 16.11 1280 151206 1109036 89366925
Syncope 104.66 16.11 46 152440 132617 90343344
Somnolence 102.90 16.11 120 152366 208964 90266997
Hepatic cirrhosis 101.28 16.11 284 152202 62969 90412992
Anaphylactic reaction 100.38 16.11 14 152472 87510 90388451
Blood creatinine increased 99.59 16.11 24 152462 101362 90374599
Lupus-like syndrome 99.47 16.11 240 152246 48606 90427355
Adverse drug reaction 98.93 16.11 424 152062 116277 90359684
Septic shock 97.61 16.11 13 152473 84147 90391814
Chest pain 97.54 16.11 892 151594 318753 90157208
Live birth 97.46 16.11 324 152162 78783 90397178
Drug interaction 97.42 16.11 199 152287 276254 90199707
Dry skin 94.43 16.11 17 152469 88056 90387905
Asthma 94.29 16.11 714 151772 241446 90234515
Injection site erythema 93.51 16.11 25 152461 98477 90377484
Renal failure 93.41 16.11 52 152434 130955 90345006
Interstitial lung disease 93.06 16.11 10 152476 76395 90399566
Rash vesicular 93 16.11 133 152353 18064 90457897
Foot deformity 90.81 16.11 263 152223 59388 90416573
Aspartate aminotransferase increased 90.67 16.11 30 152456 102907 90373054
Hyponatraemia 89.59 16.11 57 152429 133481 90342480
Pustular psoriasis 89.56 16.11 132 152354 18424 90457537
Dyspnoea exertional 89.24 16.11 9 152477 72279 90403682
Rhinorrhoea 88.54 16.11 20 152466 88296 90387665
Dysphagia 88.46 16.11 39 152447 112239 90363722
Seizure 88.38 16.11 76 152410 152553 90323408
Sinusitis 87.85 16.11 923 151563 342165 90133796
Hypertension 87.60 16.11 1164 151322 456368 90019593
Chest discomfort 87.55 16.11 63 152423 138302 90337659
Respiratory failure 87.37 16.11 45 152441 118373 90357588
Maternal exposure during pregnancy 86.33 16.11 956 151530 359107 90116854
Epistaxis 85.90 16.11 19 152467 85106 90390855
Neutrophil count decreased 85.52 16.11 10 152476 71522 90404439
Thrombocytopenia 85.38 16.11 137 152349 208588 90267373
Pulmonary embolism 84.84 16.11 58 152428 130762 90345199
Contraindicated product administered 84.20 16.11 866 151620 319273 90156688
Cerebrovascular accident 83.88 16.11 52 152434 123481 90352480
Myocardial infarction 81.62 16.11 38 152448 105934 90370027
Back disorder 81.39 16.11 151 152335 25480 90450481
Therapeutic product effect decreased 81.33 16.11 768 151718 276803 90199158
Drug tolerance decreased 81.18 16.11 172 152314 31958 90444003
Prescribed underdose 80.90 16.11 294 152192 74725 90401236
Infection 80.77 16.11 948 151538 361146 90114815
Productive cough 78.16 16.11 17 152469 77046 90398915
Incorrect route of product administration 76.86 16.11 223 152263 50403 90425558
Myositis 76.44 16.11 142 152344 23986 90451975
Cellulitis 76.37 16.11 29 152457 91308 90384653
Hyperkalaemia 75.42 16.11 10 152476 64954 90411007
Injection site swelling 75.05 16.11 7 152479 59832 90416129
Feeling abnormal 74.97 16.11 103 152383 167132 90308829
Atrial fibrillation 74.39 16.11 69 152417 133542 90342419
Flushing 74.15 16.11 28 152458 88463 90387498
Blood glucose increased 73.59 16.11 34 152452 95212 90380749
Nasopharyngitis 73.50 16.11 1025 151461 406079 90069882
Eczema 72.57 16.11 4 152482 52866 90423095
Chills 72.49 16.11 69 152417 131912 90344049
Chronic kidney disease 71.46 16.11 3 152483 50188 90425773
Blood pressure systolic increased 70.14 16.11 8 152478 58337 90417624
Drug intolerance 68.36 16.11 1095 151391 446496 90029465
Haematochezia 67.30 16.11 18 152468 70895 90405066
Memory impairment 67.14 16.11 564 151922 196680 90279281
Eye injury 66.05 16.11 87 152399 10933 90465028
Therapy interrupted 65.20 16.11 5 152481 50103 90425858
Wrong technique in product usage process 64.55 16.11 20 152466 71551 90404410
Angioedema 64.42 16.11 15 152471 64861 90411100
Ear infection 63.40 16.11 259 152227 69516 90406445
Gastrointestinal haemorrhage 62.65 16.11 37 152449 90211 90385750
Chronic obstructive pulmonary disease 62.46 16.11 23 152463 73806 90402155
Neoplasm progression 62.22 16.11 3 152483 44483 90431478
Tremor 62.19 16.11 101 152385 153072 90322889
Heart rate increased 62.03 16.11 59 152427 112843 90363118
Cataract 61.77 16.11 22 152464 72070 90403891
Hyperhidrosis 61.04 16.11 84 152402 136221 90339740
Rash erythematous 60.90 16.11 17 152469 65087 90410874
Pneumonia 60.47 16.11 735 151751 637324 89838637
Bradycardia 60.17 16.11 33 152453 83814 90392147
Swollen joint count 59.26 16.11 73 152413 8580 90467381
Hypoxia 58.86 16.11 24 152462 72375 90403586
Multiple organ dysfunction syndrome 58.30 16.11 21 152465 68315 90407646
Unevaluable event 57.91 16.11 11 152475 54837 90421124
Swelling face 56.97 16.11 33 152453 81319 90394642
Thrombosis 56.82 16.11 26 152460 73225 90402736
Burning sensation 56.74 16.11 18 152468 63434 90412527
Pain in jaw 56.64 16.11 7 152479 47978 90427983
Blood pressure fluctuation 56.44 16.11 10 152476 52403 90423558
Device expulsion 56.41 16.11 3 152483 40883 90435078
Dysphonia 56.23 16.11 18 152468 63066 90412895
Respiratory disorder 56.07 16.11 237 152249 64579 90411382
Mucosal inflammation 55.89 16.11 14 152472 57611 90418350
Vision blurred 55.65 16.11 62 152424 110231 90365730
Blood bilirubin increased 54.74 16.11 5 152481 43465 90432496
Injection site pruritus 54.34 16.11 12 152474 53822 90422139
Hypothyroidism 53.31 16.11 12 152474 53115 90422846
Throat irritation 53.07 16.11 9 152477 48686 90427275
Palpitations 52.88 16.11 93 152393 136635 90339326
Skin exfoliation 52.84 16.11 24 152462 67889 90408072
Colitis 52.45 16.11 26 152460 69916 90406045
Deep vein thrombosis 51.37 16.11 47 152439 91573 90384388
Joint dislocation 50.86 16.11 178 152308 44404 90431557
Plasma cell myeloma 50.61 16.11 5 152481 40823 90435138
Dysgeusia 50.53 16.11 13 152473 52547 90423414
No adverse event 49.89 16.11 26 152460 67956 90408005
Diarrhoea 49.86 16.11 1202 151284 937988 89537973
Hot flush 49.54 16.11 19 152467 59469 90416492
Influenza like illness 49.31 16.11 38 152448 80573 90395388
Macular degeneration 48.82 16.11 4 152482 37966 90437995
Injection site bruising 48.29 16.11 14 152472 52293 90423668
Osteonecrosis of jaw 47.92 16.11 5 152481 39098 90436863
Acute respiratory failure 46.62 16.11 8 152478 42910 90433051
Hypoglycaemia 46.58 16.11 30 152456 69818 90406143
Staphylococcal infection 46.53 16.11 12 152474 48427 90427534
Heart rate decreased 46.40 16.11 16 152470 53489 90422472
Product use issue 46.21 16.11 796 151690 329123 90146838
Cholestasis 46.18 16.11 4 152482 36295 90439666
Clostridium difficile infection 46.10 16.11 4 152482 36241 90439720
Renal disorder 45.99 16.11 5 152481 37854 90438107
Anxiety 45.80 16.11 754 151732 309018 90166943
Ascites 45.53 16.11 12 152474 47728 90428233
Surgery 45.32 16.11 10 152476 44877 90431084
Fatigue 44.59 16.11 1543 150943 1152480 89323481
Agranulocytosis 44.14 16.11 4 152482 34998 90440963
Hypokalaemia 43.96 16.11 97 152389 131019 90344942
Abdominal distension 43.47 16.11 97 152389 130504 90345457
Disease recurrence 43.22 16.11 6 152480 37647 90438314
International normalised ratio increased 43.07 16.11 13 152473 47303 90428658
Hypophagia 43.01 16.11 5 152481 35932 90440029
Weight increased 42.89 16.11 962 151524 416965 90058996
Creatinine renal clearance increased 42.77 16.11 39 152447 3242 90472719
Bone marrow failure 42.54 16.11 3 152483 32218 90443743
Neoplasm malignant 42.39 16.11 4 152482 33876 90442085
Fungal infection 42.08 16.11 10 152476 42651 90433310
Stress 41.90 16.11 45 152441 81350 90394611
Pulmonary hypertension 41.88 16.11 10 152476 42513 90433448
Gait disturbance 41.86 16.11 643 151843 259853 90216108
Blood potassium decreased 41.86 16.11 14 152472 47713 90428248
Dry eye 41.28 16.11 23 152463 57908 90418053
Lethargy 40.92 16.11 28 152458 63111 90412850
Mouth ulceration 40.17 16.11 9 152477 39965 90435996
Blood pressure decreased 40.14 16.11 40 152446 74855 90401106
Candida infection 40.12 16.11 5 152481 34052 90441909
Oxygen saturation decreased 39.87 16.11 75 152411 107408 90368553
Neonatal hypoxia 39.82 16.11 21 152465 710 90475251
Pericardial effusion 39.72 16.11 7 152479 36826 90439135
Rash maculo-papular 39.59 16.11 10 152476 40923 90435038
Haemorrhage 39.58 16.11 35 152451 69334 90406627
Lymphadenopathy 39.16 16.11 14 152472 45761 90430200
Drug reaction with eosinophilia and systemic symptoms 38.46 16.11 12 152474 42746 90433215
Red blood cell count decreased 38.27 16.11 15 152471 46336 90429625
Lip swelling 38.18 16.11 9 152477 38601 90437360
Accidental exposure to product 37.91 16.11 12 152474 42354 90433607
Femur fracture 37.91 16.11 15 152471 46067 90429894
Toxic epidermal necrolysis 37.77 16.11 5 152481 32523 90443438
Drug ineffective for unapproved indication 37.58 16.11 34 152452 66610 90409351
Medication error 37.16 16.11 257 152229 84395 90391566
Coronary artery disease 37.12 16.11 6 152480 33617 90442344
Pulmonary oedema 37.04 16.11 30 152456 62050 90413911
Pneumonitis 36.96 16.11 14 152472 44156 90431805
Suicidal ideation 36.73 16.11 42 152444 73813 90402148
Upper respiratory tract infection 36.71 16.11 103 152383 128215 90347746
Haemoptysis 36.66 16.11 6 152480 33314 90442647
Premature delivery 36.48 16.11 10 152476 38752 90437209
Hypercalcaemia 35.86 16.11 7 152479 34233 90441728
Blood alkaline phosphatase increased 35.86 16.11 18 152468 48061 90427900
Oral pain 35.71 16.11 6 152480 32677 90443284
Peripheral swelling 35.46 16.11 928 151558 412178 90063783
Gamma-glutamyltransferase increased 35.33 16.11 10 152476 37942 90438019
Lymphocyte count decreased 35 16.11 8 152478 35042 90440919
Condition aggravated 34.93 16.11 1277 151209 594268 89881693
Pulmonary mass 34.44 16.11 4 152482 28768 90447193
Multiple sclerosis relapse 34.16 16.11 23 152463 52282 90423679
Clostridium difficile colitis 33.82 16.11 3 152483 26703 90449258
Hepatic function abnormal 33.53 16.11 18 152468 46270 90429691
Injection site reaction 33.50 16.11 65 152421 92015 90383946
Tooth disorder 33.33 16.11 6 152480 31084 90444877
Diabetes mellitus 33.24 16.11 36 152450 64839 90411122
Lactic acidosis 33.21 16.11 22 152464 50441 90425520
Swollen tongue 33.10 16.11 18 152468 45938 90430023
Incorrect dose administered 33.02 16.11 51 152435 78879 90397082
Stevens-Johnson syndrome 32.98 16.11 5 152481 29371 90446590
Hypocalcaemia 32.92 16.11 15 152471 42353 90433608
Intentional self-injury 32.91 16.11 5 152481 29329 90446632
Nephrolithiasis 32.84 16.11 21 152465 49064 90426897
Basal cell carcinoma 32.59 16.11 8 152478 33381 90442580
Sleep disorder due to a general medical condition 32.25 16.11 155 152331 44583 90431378
Loss of consciousness 32.22 16.11 124 152362 140114 90335847
Cardiac disorder 32.08 16.11 29 152457 56843 90419118
Metastases to bone 31.94 16.11 3 152483 25502 90450459
Product prescribing error 31.92 16.11 6 152480 30139 90445822
Tubulointerstitial nephritis 31.68 16.11 3 152483 25340 90450621
Eye irritation 31.54 16.11 9 152477 33969 90441992
Skin ulcer 31.40 16.11 23 152463 50052 90425909
Hepatitis 31.26 16.11 44 152442 70695 90405266
Hyperglycaemia 31.21 16.11 24 152462 50946 90425015
Blindness 31.05 16.11 4 152482 26564 90449397
Device issue 31.02 16.11 6 152480 29531 90446430
Palmar-plantar erythrodysaesthesia syndrome 30.94 16.11 5 152481 28018 90447943
Intestinal obstruction 30.69 16.11 12 152474 37119 90438842
Osteomyelitis 30.67 16.11 5 152481 27841 90448120
Procedural pain 30.66 16.11 9 152477 33351 90442610
Ejection fraction decreased 30.57 16.11 4 152482 26249 90449712
Gastroenteritis 30.56 16.11 6 152480 29223 90446738
Dysuria 30.53 16.11 14 152472 39387 90436574
Bronchitis 30.35 16.11 143 152343 152784 90323177
Presyncope 30.32 16.11 8 152478 31797 90444164
Hip fracture 30.26 16.11 9 152477 33068 90442893
Renal function test abnormal 30.25 16.11 48 152438 7143 90468818
Paraesthesia oral 30.11 16.11 8 152478 31651 90444310
Altered state of consciousness 29.93 16.11 8 152478 31524 90444437
Gastrooesophageal reflux disease 29.90 16.11 161 152325 166176 90309785
Injection site rash 29.86 16.11 3 152483 24170 90451791
Device dislocation 29.85 16.11 8 152478 31474 90444487
Speech disorder 29.83 16.11 20 152466 45565 90430396
Hypervolaemia 29.81 16.11 9 152477 32748 90443213
Joint stiffness 29.70 16.11 229 152257 77813 90398148
Joint injury 29.68 16.11 9 152477 32655 90443306
Inflammation 29.51 16.11 443 152043 178149 90297812
Colitis ulcerative 29.49 16.11 188 152298 60078 90415883
Jaundice 29.47 16.11 9 152477 32508 90443453
Neck pain 29.36 16.11 96 152390 113867 90362094
Diverticulitis 29.33 16.11 20 152466 45167 90430794
Vertigo 29.30 16.11 45 152441 69766 90406195
Precancerous cells present 29.25 16.11 23 152463 1560 90474401
Haematocrit decreased 29.24 16.11 17 152469 41815 90434146
Localised infection 29.17 16.11 10 152476 33552 90442409
Melaena 29.16 16.11 11 152475 34786 90441175
Blood pressure diastolic decreased 29.14 16.11 5 152481 26821 90449140
Red blood cell sedimentation rate increased 29.05 16.11 238 152248 82357 90393604
Angina pectoris 28.70 16.11 15 152471 39145 90436816
Haematoma 28.55 16.11 15 152471 39033 90436928
Hallucination, visual 28.17 16.11 3 152483 23089 90452872
Transient ischaemic attack 28.17 16.11 19 152467 43157 90432804
Rash macular 28.14 16.11 8 152478 30272 90445689
Metastases to liver 27.93 16.11 7 152479 28800 90447161
Eye disorder 27.86 16.11 6 152480 27384 90448577
Ocular hyperaemia 27.80 16.11 11 152475 33787 90442174
Diabetic ketoacidosis 27.76 16.11 4 152482 24403 90451558
Aphasia 27.72 16.11 19 152467 42793 90433168
Psychotic disorder 27.67 16.11 9 152477 31221 90444740
Vasculitis 27.56 16.11 3 152483 22690 90453271
Dyspnoea 27.55 16.11 1207 151279 879748 89596213
Red blood cell sedimentation rate abnormal 27.45 16.11 4 152482 24200 90451761
Dysarthria 27.07 16.11 31 152455 54451 90421510
Therapy partial responder 26.55 16.11 3 152483 22040 90453921
Leukopenia 26.53 16.11 84 152402 100626 90375335
Skin lesion 26.38 16.11 15 152471 37350 90438611
Hepatocellular injury 26.28 16.11 8 152478 28950 90447011
Haematemesis 26.11 16.11 12 152474 33714 90442247
Face oedema 26.11 16.11 4 152482 23314 90452647
Respiratory tract congestion 25.93 16.11 7 152479 27403 90448558
Head injury 25.90 16.11 10 152476 31178 90444783
Upper limb fracture 25.83 16.11 3 152483 21575 90454386
Kidney infection 25.71 16.11 6 152480 25910 90450051
Leukocytosis 25.63 16.11 10 152476 30980 90444981
Cerebral haemorrhage 25.63 16.11 13 152473 34509 90441452
Drug hypersensitivity 25.45 16.11 987 151499 462622 90013339
Lymphopenia 25.45 16.11 4 152482 22877 90453084
Oral candidiasis 25.37 16.11 14 152472 35441 90440520
Drug eruption 25.31 16.11 14 152472 35393 90440568
Cardiac arrest 25.27 16.11 91 152395 104844 90371117
Pollakiuria 25.15 16.11 12 152474 32993 90442968
Therapeutic product effect incomplete 25.12 16.11 207 152279 193689 90282272
Listless 24.86 16.11 29 152457 3220 90472741
Electrocardiogram QT prolonged 24.78 16.11 53 152433 72403 90403558
Viral infection 24.73 16.11 20 152466 41394 90434567
Chronic sinusitis 24.65 16.11 5 152481 23797 90452164
Acute myocardial infarction 24.64 16.11 14 152472 34876 90441085
Rhabdomyolysis 24.57 16.11 30 152456 51226 90424735
Dermatitis 24.45 16.11 4 152482 22216 90453745
Blood sodium decreased 24.39 16.11 8 152478 27605 90448356
Eye pain 24.35 16.11 23 152463 44145 90431816
Osteonecrosis 24.26 16.11 7 152479 26234 90449727
Sinus disorder 24.08 16.11 14 152472 34433 90441528
Proteinuria 23.90 16.11 5 152481 23286 90452675
Mental status changes 23.78 16.11 24 152462 44655 90431306
Cardiomyopathy 23.72 16.11 3 152483 20203 90455758
Rheumatoid nodule 23.66 16.11 3 152483 20163 90455798
Lacrimation increased 23.63 16.11 8 152478 27054 90448907
Device related infection 23.62 16.11 7 152479 25779 90450182
Flatulence 23.45 16.11 21 152465 41346 90434615
Transaminases increased 23.43 16.11 17 152469 37175 90438786
Eating disorder 23.32 16.11 9 152477 28064 90447897
Blood urea increased 23.27 16.11 11 152475 30402 90445559
Gastroenteritis viral 23.19 16.11 11 152475 30344 90445617
Tendonitis 23.18 16.11 4 152482 21368 90454593
Haemorrhoids 23.13 16.11 8 152478 26694 90449267
Hospitalisation 23.01 16.11 124 152362 127976 90347985
Eye pruritus 22.99 16.11 10 152476 29017 90446944
Tachycardia 22.93 16.11 163 152323 157510 90318451
Hallucination 22.76 16.11 48 152438 65911 90410050
Gastritis 22.72 16.11 22 152464 41731 90434230
Musculoskeletal discomfort 22.61 16.11 4 152482 20987 90454974
Urinary incontinence 22.60 16.11 18 152468 37548 90438413
Blood test abnormal 22.55 16.11 4 152482 20948 90455013
Bacteraemia 22.45 16.11 5 152481 22295 90453666
Sinus congestion 22.44 16.11 9 152477 27415 90448546
Diaphragmatic rupture 22.18 16.11 10 152476 238 90475723
Acute myeloid leukaemia 22.09 16.11 4 152482 20636 90455325
Blood lactate dehydrogenase increased 22.07 16.11 8 152478 25924 90450037
Spinal fracture 22.03 16.11 5 152481 22011 90453950
Pharyngitis 21.93 16.11 5 152481 21942 90454019
Eye swelling 21.92 16.11 11 152475 29375 90446586
Derailment 21.91 16.11 7 152479 61 90475900
Foetal exposure during pregnancy 21.85 16.11 24 152462 42951 90433010
Respiratory distress 21.80 16.11 20 152466 38926 90437035
Hepatotoxicity 21.80 16.11 27 152459 45815 90430146
Tenderness 21.69 16.11 9 152477 26859 90449102
Nightmare 21.61 16.11 5 152481 21720 90454241
Hiatus hernia 21.28 16.11 8 152478 25353 90450608
Neurotoxicity 21.24 16.11 5 152481 21462 90454499
Respiratory tract infection 21.23 16.11 42 152444 59036 90416925
Pancreatitis acute 21.13 16.11 14 152472 32101 90443860
Shock 21.12 16.11 11 152475 28767 90447194
Rib fracture 21.10 16.11 9 152477 26426 90449535
Pyelonephritis 21.02 16.11 5 152481 21311 90454650
Urosepsis 20.90 16.11 5 152481 21227 90454734
Cholecystitis chronic 20.77 16.11 49 152437 9777 90466184
Limb discomfort 20.77 16.11 20 152466 38040 90437921
Joint effusion 20.71 16.11 4 152482 19706 90456255
Skin laceration 20.57 16.11 9 152477 26026 90449935
Sedation complication 20.50 16.11 69 152417 16875 90459086
Depressed mood 20.48 16.11 33 152453 50189 90425772
Complication associated with device 20.32 16.11 4 152482 19445 90456516
Cystitis 20.25 16.11 52 152434 66666 90409295
Neutrophil count increased 20.23 16.11 4 152482 19386 90456575
Blood potassium increased 20.20 16.11 5 152481 20744 90455217
Liver function test abnormal 20.19 16.11 34 152452 50811 90425150
Female genital tract fistula 20.15 16.11 3 152483 17865 90458096
Skin infection 20.15 16.11 3 152483 17861 90458100
Bronchospasm 20.14 16.11 5 152481 20704 90455257
Laboratory test abnormal 20.13 16.11 130 152356 41724 90434237
Disturbance in attention 20.12 16.11 30 152456 47079 90428882
Intentional dose omission 20.02 16.11 3 152483 17780 90458181
Reduced facial expression 19.89 16.11 23 152463 2530 90473431
Nodule 19.89 16.11 10 152476 26676 90449285
Bone pain 19.84 16.11 47 152439 61936 90414025
Musculoskeletal disorder 19.78 16.11 6 152480 21763 90454198
Osteopenia 19.74 16.11 7 152479 22995 90452966
Ear pain 19.61 16.11 165 152321 57537 90418424
Transfusion 19.58 16.11 3 152483 17485 90458476
Ulcer 19.48 16.11 16 152470 32866 90443095
Product storage error 19.47 16.11 5 152481 20236 90455725
Product use in unapproved indication 19.43 16.11 720 151766 335516 90140445
Electrolyte imbalance 19.09 16.11 8 152478 23737 90452224
Intervertebral disc protrusion 19.08 16.11 11 152475 27185 90448776
Dyskinesia 19.02 16.11 20 152466 36514 90439447
Restless legs syndrome 19.00 16.11 7 152479 22463 90453498
Radiculopathy 18.93 16.11 4 152482 18501 90457460
Frequent bowel movements 18.92 16.11 162 152324 56773 90419188
Gastric disorder 18.86 16.11 17 152469 33367 90442594
Sinus bradycardia 18.77 16.11 3 152483 16949 90459012
Infusion site pain 18.75 16.11 5 152481 19733 90456228
Glomerular filtration rate decreased 18.74 16.11 3 152483 16929 90459032
Device malfunction 18.67 16.11 6 152480 20971 90454990
Middle insomnia 18.47 16.11 3 152483 16748 90459213
Conjunctivitis 18.46 16.11 11 152475 26695 90449266
Anoxia 18.36 16.11 9 152477 260 90475701
Vaginal discharge 18.35 16.11 5 152481 19459 90456502
Foot fracture 18.33 16.11 11 152475 26595 90449366
Haematuria 18.33 16.11 19 152467 34918 90441043
Bone disorder 18.25 16.11 8 152478 23112 90452849
Therapeutic response unexpected 18.20 16.11 7 152479 21873 90454088
Product appearance confusion 18.14 16.11 7 152479 111 90475850
Feeling cold 18.04 16.11 12 152474 27453 90448508
Acne 18.00 16.11 13 152473 28494 90447467
Hyperlipidaemia 17.98 16.11 8 152478 22908 90453053
Creatinine renal clearance decreased 17.84 16.11 71 152415 18828 90457133
Extrapyramidal disorder 17.79 16.11 3 152483 16300 90459661
Pneumonia aspiration 17.56 16.11 26 152460 40914 90435047
Pallor 17.46 16.11 19 152467 34146 90441815
Ageusia 17.45 16.11 3 152483 16073 90459888
Small intestinal obstruction 17.32 16.11 7 152479 21227 90454734
Posterior reversible encephalopathy syndrome 17.21 16.11 8 152478 22331 90453630
Generalised tonic-clonic seizure 17.19 16.11 20 152466 34883 90441078
Bacterial infection 17.15 16.11 9 152477 23435 90452526
Blood urine present 17.14 16.11 4 152482 17274 90458687
Drug level increased 17.09 16.11 13 152473 27749 90448212
Malnutrition 17.07 16.11 5 152481 18553 90457408
Pancreatitis 16.96 16.11 186 152300 69640 90406321
Hypokinesia 16.89 16.11 3 152483 15694 90460267
Injection site mass 16.88 16.11 8 152478 22082 90453879
Wrist fracture 16.78 16.11 3 152483 15621 90460340
Skin burning sensation 16.77 16.11 6 152480 19605 90456356
Encephalopathy 16.70 16.11 33 152453 46411 90429550
Glycosylated haemoglobin increased 16.69 16.11 3 152483 15559 90460402
Throat tightness 16.67 16.11 15 152471 29469 90446492
Carbuncle 16.66 16.11 16 152470 1420 90474541
Breath sounds abnormal 16.42 16.11 3 152483 15383 90460578
Breast cancer 16.24 16.11 42 152444 53719 90422242

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1215.85 15.60 751 10613 228385 42381586
Overdose 318.18 15.60 246 11118 105018 42504953
Completed suicide 206.86 15.60 185 11179 96280 42513691
Drug abuse 189.97 15.60 183 11181 104588 42505383
Neonatal hypoxia 167.18 15.60 37 11327 523 42609448
Adulterated product 124.94 15.60 31 11333 735 42609236
Accidental death 100.94 15.60 36 11328 3047 42606924
Intentional overdose 78.53 15.60 82 11282 51374 42558597
Maternal exposure before pregnancy 73.76 15.60 22 11342 1055 42608916
Intentional product misuse 71.03 15.60 85 11279 61815 42548156
Cardio-respiratory arrest 58.39 15.60 75 11289 58561 42551410
Drug interaction 50.48 15.60 171 11193 266828 42343143
Brain oedema 48.74 15.60 38 11326 16289 42593682
Pulmonary oedema 48.18 15.60 65 11299 53207 42556764
Cardiac arrest 41.92 15.60 91 11273 109229 42500742
Alcohol interaction 37.96 15.60 16 11348 2119 42607852
Apnoea 36.79 15.60 24 11340 7779 42602192
Alcohol poisoning 32.58 15.60 22 11342 7552 42602419
Infantile apnoea 32.46 15.60 12 11352 1124 42608847
Intraventricular haemorrhage neonatal 31.68 15.60 9 11355 363 42609608
Hypertension neonatal 30.99 15.60 7 11357 109 42609862
Bradycardia neonatal 30.46 15.60 12 11352 1336 42608635
Circulatory collapse 29.64 15.60 34 11330 23602 42586369
Maternal exposure during pregnancy 29.37 15.60 20 11344 6958 42603013
Bronchopulmonary dysplasia 29.24 15.60 10 11354 747 42609224
Nightmare 28.09 15.60 34 11330 24978 42584993
Mydriasis 27.45 15.60 21 11343 8749 42601222
Accidental overdose 26.25 15.60 35 11329 28295 42581676
Sinus tachycardia 24.71 15.60 29 11335 20624 42589347
Patent ductus arteriosus 22.27 15.60 13 11351 3463 42606508
Pulmonary congestion 22.08 15.60 24 11340 15706 42594265
Asphyxia 21.90 15.60 18 11346 8308 42601663
Transverse presentation 21.89 15.60 5 11359 82 42609889
Respiratory arrest 21.70 15.60 32 11332 28392 42581579
Suicide attempt 20.72 15.60 41 11323 46059 42563912
Premature baby 19.03 15.60 27 11337 23126 42586845
Adrenergic syndrome 19.02 15.60 5 11359 150 42609821
Death 18.87 15.60 200 11164 470985 42138986
Drug tolerance increased 17.57 15.60 6 11358 446 42609525
Drug monitoring procedure not performed 17.24 15.60 6 11358 472 42609499
Hyperhidrosis 17.04 15.60 58 11306 90454 42519517
Ureteric haemorrhage 17.03 15.60 5 11359 227 42609744
Brain injury 16.97 15.60 15 11349 7640 42602331
Dry gangrene 16.89 15.60 6 11358 501 42609470
Diarrhoea 16.63 15.60 65 11299 460784 42149187
Term birth 15.92 15.60 4 11360 100 42609871

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid factor positive 740.51 16.92 855 133408 130785 110324251
Deep vein thrombosis postoperative 672.01 16.92 565 133698 58726 110396310
Swollen joint count increased 638.87 16.92 639 133624 83022 110372014
Autoimmune disorder 633.22 16.92 570 133693 64913 110390123
Duodenal ulcer perforation 618.81 16.92 911 133352 176789 110278247
Anti-cyclic citrullinated peptide antibody positive 606.56 16.92 914 133349 181070 110273966
Helicobacter infection 599.85 16.92 909 133354 180968 110274068
Hand deformity 577.03 16.92 987 133276 217519 110237517
Pemphigus 574.24 16.92 975 133288 213595 110241441
Rheumatic fever 568.30 16.92 722 133541 121857 110333179
Injury 567.71 16.92 874 133389 176391 110278645
Lower limb fracture 557.85 16.92 566 133697 74782 110380254
Liver injury 556.97 16.92 794 133469 149619 110305417
Discomfort 544.90 16.92 953 133310 213754 110241282
Pericarditis 535.99 16.92 957 133306 218157 110236879
Glossodynia 519.32 16.92 951 133312 221053 110233983
Blood cholesterol increased 498.73 16.92 843 133420 183942 110271094
Muscle injury 496.03 16.92 726 133537 140081 110314955
Fibromyalgia 485.70 16.92 798 133465 170111 110284925
Folliculitis 484.83 16.92 789 133474 166864 110288172
Mobility decreased 455.05 16.92 935 133328 236487 110218549
Wound 454.94 16.92 928 133335 233509 110221527
C-reactive protein abnormal 451.44 16.92 665 133598 129030 110326006
Type 2 diabetes mellitus 444.77 16.92 783 133480 176449 110278587
Systemic lupus erythematosus 441.57 16.92 962 133301 253376 110201660
Psoriatic arthropathy 441.42 16.92 828 133435 195933 110259103
Acute kidney injury 437.28 16.92 116 134147 635314 109819722
Road traffic accident 427.31 16.92 587 133676 106811 110348225
Lip dry 425.56 16.92 565 133698 99518 110355518
Sciatica 423.03 16.92 541 133722 91858 110363178
Irritable bowel syndrome 408.80 16.92 723 133540 163492 110291544
Blister 408.36 16.92 872 133391 226504 110228532
Sleep disorder due to general medical condition, insomnia type 392.86 16.92 559 133704 105084 110349952
Arthropathy 391.57 16.92 989 133274 286533 110168503
Adjustment disorder with depressed mood 391.04 16.92 365 133898 43518 110411518
Synovitis 378.66 16.92 948 133315 273144 110181892
Hepatic enzyme increased 372.34 16.92 1040 133223 319852 110135184
Lupus vulgaris 371.74 16.92 317 133946 33566 110421470
Anaemia 366.68 16.92 105 134158 546981 109908055
Impaired healing 353.81 16.92 755 133508 195962 110259074
Joint range of motion decreased 350.22 16.92 572 133691 121260 110333776
Bursitis 328.43 16.92 576 133687 129342 110325694
Peripheral venous disease 321.44 16.92 451 133812 83666 110371370
Oedema 317.34 16.92 752 133511 209224 110245812
Lower respiratory tract infection 305.91 16.92 812 133451 242294 110212742
Night sweats 305.52 16.92 568 133695 133415 110321621
Alopecia 299.00 16.92 1048 133215 363705 110091331
Dislocation of vertebra 293.94 16.92 312 133951 43409 110411627
Prescribed overdose 290.23 16.92 439 133824 87142 110367894
X-ray abnormal 288.72 16.92 290 133973 37827 110417209
Cough 285.46 16.92 102 134161 461539 109993497
Osteoarthritis 278.02 16.92 656 133607 181967 110273069
Neutropenia 275.90 16.92 59 134204 374561 110080475
Gait inability 272.81 16.92 547 133716 135829 110319207
Facet joint syndrome 269.33 16.92 448 133815 96380 110358656
Musculoskeletal stiffness 266.56 16.92 846 133417 278976 110176060
Toxicity to various agents 265.67 16.92 1221 133042 479334 109975702
Product dose omission issue 259.97 16.92 40 134223 321742 110133294
Ill-defined disorder 256.97 16.92 580 133683 156273 110298763
Abdominal discomfort 249.01 16.92 1042 133221 392816 110062220
Pregnancy 243.14 16.92 305 133958 50762 110404274
Stomatitis 242.87 16.92 801 133462 269441 110185595
Rheumatoid arthritis 238.65 16.92 853 133410 298760 110156276
Liver disorder 238.62 16.92 531 133732 141712 110313324
Contusion 237.44 16.92 722 133541 232639 110222397
Grip strength decreased 236.56 16.92 381 133882 79793 110375243
Hip arthroplasty 235.48 16.92 314 133949 55499 110399537
Breast cancer stage III 234.84 16.92 377 133886 78740 110376296
Pulmonary fibrosis 234.34 16.92 434 133829 101608 110353428
Retinitis 232.17 16.92 239 134024 32088 110422948
C-reactive protein 231.98 16.92 232 134031 30099 110424937
Maternal exposure during pregnancy 230.39 16.92 757 133506 254126 110200910
Sepsis 228.23 16.92 58 134205 327288 110127748
Hypoaesthesia 227.14 16.92 867 133396 313356 110141680
Hypercholesterolaemia 224.67 16.92 399 133864 90438 110364598
Dry mouth 217.01 16.92 633 133630 199315 110255721
Swelling 216.58 16.92 922 133341 350119 110104917
Obesity 216.40 16.92 446 133817 112905 110342131
Bone erosion 211.34 16.92 271 133992 46100 110408936
Exostosis 210.11 16.92 269 133994 45687 110409349
Musculoskeletal pain 207.88 16.92 589 133674 182434 110272602
Infusion related reaction 205.69 16.92 962 133301 380200 110074836
Anti-cyclic citrullinated peptide antibody 205.24 16.92 180 134083 19784 110435252
Lung disorder 202.13 16.92 577 133686 179470 110275566
Disease progression 193.32 16.92 32 134231 244002 110211034
Hypersensitivity 192.49 16.92 984 133279 403014 110052022
Neuropathy peripheral 186.76 16.92 7 134256 179270 110275766
Treatment failure 185.74 16.92 747 133516 276487 110178549
Erythema 184.17 16.92 62 134201 291385 110163651
Pancytopenia 183.82 16.92 20 134243 209593 110245443
Gastrointestinal disorder 181.72 16.92 676 133587 241276 110213760
Knee arthroplasty 179.90 16.92 300 133963 64648 110390388
Grip strength 179.22 16.92 121 134142 9020 110446016
Contraindicated product administered 178.48 16.92 684 133579 247583 110207453
Maternal exposure timing unspecified 174.24 16.92 168 134095 20845 110434191
Urticaria 173.60 16.92 807 133456 318050 110136986
Laryngitis 173.39 16.92 235 134028 42176 110412860
Urinary tract infection 173.11 16.92 90 134173 326192 110128844
Joint swelling 172.97 16.92 1022 133241 441823 110013213
Porphyria acute 172.67 16.92 159 134104 18621 110436415
Abdominal pain upper 170.94 16.92 857 133406 348254 110106782
Wound infection 170.68 16.92 368 133895 96097 110358939
Platelet count decreased 170.18 16.92 36 134227 230407 110224629
COVID-19 169.66 16.92 44 134219 245016 110210020
Febrile neutropenia 168.61 16.92 87 134176 316680 110138356
Amnesia 168.37 16.92 386 133877 105022 110350014
Lupus-like syndrome 165.21 16.92 225 134038 40567 110414469
Off label use 163.06 16.92 1111 133152 1499074 108955962
Sinusitis 163.04 16.92 753 133510 295935 110159101
Sleep disorder 162.72 16.92 571 133692 198073 110256963
Hypotension 162.69 16.92 240 134023 523609 109931427
Foot deformity 161.96 16.92 244 134019 48236 110406800
Live birth 161.35 16.92 297 133966 69187 110385849
Cardiac failure 156.89 16.92 21 134242 187605 110267431
Walking aid user 152.91 16.92 170 134093 24905 110430131
Wheezing 152.40 16.92 664 133599 254566 110200470
Migraine 151.60 16.92 506 133757 171146 110283890
General physical health deterioration 148.72 16.92 954 133309 424341 110030695
Adverse event 147.54 16.92 374 133889 108435 110346601
Asthma 147.04 16.92 648 133615 249643 110205393
Ulcer haemorrhage 146.28 16.92 158 134105 22413 110432623
Fall 145.75 16.92 323 133940 603159 109851877
Delirium 143.11 16.92 424 133839 134601 110320435
Blood pressure increased 140.42 16.92 69 134194 258304 110196732
Breast cancer stage II 139.15 16.92 169 134094 27206 110427830
Malignant neoplasm progression 137.99 16.92 23 134240 174544 110280492
Therapeutic product effect decreased 137.09 16.92 624 133639 243692 110211344
Myalgia 135.85 16.92 50 134213 222331 110232705
Renal failure 133.34 16.92 54 134209 226520 110228516
Injection site pain 133.00 16.92 27 134236 177895 110277141
Haemoglobin decreased 132.80 16.92 68 134195 248659 110206377
Hepatic cirrhosis 131.28 16.92 268 133995 67358 110387678
Prescribed underdose 130.95 16.92 262 134001 64912 110390124
White blood cell count decreased 129.68 16.92 58 134205 229332 110225704
Respiratory failure 128.89 16.92 50 134213 215282 110239754
Thrombocytopenia 128.88 16.92 140 134123 348745 110106291
Interstitial lung disease 128.19 16.92 11 134252 139323 110315713
Blood creatinine increased 128.19 16.92 32 134231 182857 110272179
Septic shock 126.20 16.92 20 134243 157508 110297528
Therapy non-responder 126.06 16.92 449 133814 156858 110298178
Renal impairment 124.51 16.92 37 134226 188408 110266628
Dehydration 123.62 16.92 95 134168 279416 110175620
Drug ineffective 122.62 16.92 1219 133044 1519321 108935715
Cardiac failure congestive 116.92 16.92 21 134242 150979 110304057
Ear infection 116.36 16.92 244 134019 62488 110392548
Drug tolerance decreased 116.23 16.92 155 134108 27385 110427651
Pleural effusion 115.41 16.92 36 134227 177673 110277363
Nasopharyngitis 114.32 16.92 845 133418 393516 110061520
Dyspepsia 114.08 16.92 497 133766 190468 110264568
Death 112.41 16.92 452 133811 698417 109756619
Pneumonia 111.15 16.92 618 133645 876096 109578940
Multiple organ dysfunction syndrome 109.35 16.92 25 134238 151685 110303351
Inappropriate schedule of product administration 108.21 16.92 56 134207 203581 110251455
Bradycardia 107.47 16.92 28 134235 155489 110299547
Confusional state 106.49 16.92 950 133313 467730 109987306
Hyperkalaemia 104.89 16.92 19 134244 135777 110319259
Exposure during pregnancy 104.05 16.92 441 133822 166983 110288053
Infection 103.20 16.92 773 133490 361427 110093609
Alanine aminotransferase increased 103.03 16.92 47 134216 183726 110271310
Disability 100.78 16.92 152 134111 30071 110424965
Atrial fibrillation 99.07 16.92 80 134183 229562 110225474
Hyponatraemia 98.77 16.92 72 134191 217581 110237455
Somnolence 98.50 16.92 130 134133 297319 110157717
Adverse drug reaction 98.38 16.92 317 133946 105242 110349794
Influenza 98.35 16.92 41 134222 169060 110285976
Neutrophil count decreased 95.43 16.92 16 134247 120925 110334111
Drug intolerance 94.38 16.92 828 133435 405684 110049352
Respiratory disorder 93.27 16.92 242 134021 71140 110383896
Productive cough 92.72 16.92 14 134249 114291 110340745
Joint dislocation 92.09 16.92 156 134107 34034 110421002
Incorrect route of product administration 91.87 16.92 225 134038 63836 110391200
Gastrointestinal haemorrhage 88.70 16.92 45 134218 165473 110289563
Oropharyngeal pain 88.56 16.92 27 134236 135249 110319787
Pulmonary embolism 88.49 16.92 78 134185 214396 110240640
Memory impairment 88.31 16.92 472 133791 196472 110258564
Syncope 86.81 16.92 71 134192 202465 110252571
Hypoxia 86.33 16.92 25 134238 129490 110325546
Dyspnoea exertional 86.14 16.92 12 134251 104048 110350988
Anaphylactic reaction 84.06 16.92 18 134245 114282 110340754
Intentional product use issue 84.01 16.92 552 133711 247354 110207682
Aspartate aminotransferase increased 83.46 16.92 45 134218 159891 110295145
Dry skin 83.28 16.92 15 134248 107638 110347398
Illness 82.93 16.92 4 134259 82167 110372869
Myocardial infarction 82.74 16.92 67 134196 192016 110263020
Nasal congestion 82.14 16.92 11 134252 98271 110356765
Dysphagia 81.95 16.92 42 134221 153558 110301478
Chills 81.44 16.92 67 134196 190513 110264523
Back pain 81.16 16.92 209 134054 370787 110084249
Product use issue 80.33 16.92 650 133613 311045 110143991
Anxiety 79.09 16.92 701 133562 344377 110110659
Adulterated product 79.01 16.92 35 134228 1120 110453916
Swollen joint count 78.88 16.92 73 134190 8601 110446435
Herpes zoster 77.82 16.92 18 134245 108361 110346675
Chronic obstructive pulmonary disease 76.67 16.92 19 134244 109139 110345897
Drug interaction 75.68 16.92 331 133932 499852 109955184
Injection site erythema 75.32 16.92 12 134251 94164 110360872
Constipation 74.89 16.92 206 134057 357580 110097456
Decreased appetite 74.44 16.92 894 133369 474952 109980084
Inflammation 74.01 16.92 444 133819 192794 110262242
Epistaxis 73.60 16.92 33 134230 130339 110324697
Chest discomfort 73.20 16.92 62 134201 173786 110281250
Chest pain 72.54 16.92 737 133526 375638 110079398
Seizure 71.86 16.92 98 134165 221087 110233949
Cellulitis 70.98 16.92 32 134231 125984 110329052
Hypertension 70.70 16.92 937 133326 509147 109945889
Weight increased 70.32 16.92 799 133464 418845 110036191
Rash erythematous 68.77 16.92 9 134254 81823 110373213
Blood glucose increased 68.08 16.92 38 134225 132458 110322578
Joint stiffness 67.30 16.92 207 134056 67036 110388000
Haematochezia 67.19 16.92 28 134235 115496 110339540
Mucosal inflammation 67.01 16.92 17 134246 96124 110358912
Cholestasis 65.56 16.92 3 134260 64515 110390521
Ascites 65.48 16.92 16 134247 92792 110362244
Thrombosis 65.38 16.92 25 134238 108637 110346399
Chronic kidney disease 65.06 16.92 8 134255 76283 110378753
Blood bilirubin increased 64.70 16.92 8 134255 75964 110379072
Angioedema 63.86 16.92 20 134243 98480 110356556
Overdose 63.19 16.92 493 133770 233301 110221735
Drug hypersensitivity 62.84 16.92 834 133429 453256 110001780
Peripheral swelling 62.68 16.92 758 133505 403276 110051760
Agranulocytosis 62.34 16.92 3 134260 61757 110393279
Red blood cell sedimentation rate increased 62.26 16.92 223 134040 78079 110376957
Haemoptysis 62.04 16.92 7 134256 71347 110383689
Blood pressure systolic increased 61.17 16.92 13 134250 82978 110372058
International normalised ratio increased 61.14 16.92 15 134248 86757 110368279
Nausea 61.07 16.92 1095 133168 1234595 109220441
Tremor 60.40 16.92 95 134168 202137 110252899
Cerebrovascular accident 58.20 16.92 81 134182 181203 110273833
Staphylococcal infection 58.04 16.92 8 134255 69936 110385100
Rhinorrhoea 57.93 16.92 26 134237 102640 110352396
Hypomagnesaemia 57.68 16.92 4 134259 60366 110394670
Hypoglycaemia 57.24 16.92 35 134228 116069 110338967
Neoplasm progression 57.02 16.92 6 134257 64589 110390447
Diarrhoea 56.51 16.92 1009 133254 1138496 109316540
Injection site swelling 56.49 16.92 5 134258 61785 110393251
Ear pain 56.22 16.92 167 134096 53059 110401977
Drug resistance 56.08 16.92 3 134260 56371 110398665
Rash maculo-papular 56.00 16.92 11 134252 74211 110380825
Skin exfoliation 54.71 16.92 19 134244 87632 110367404
Oxygen saturation decreased 54.66 16.92 66 134197 156916 110298120
Deep vein thrombosis 54.01 16.92 54 134209 139833 110315203
Subcutaneous drug absorption impaired 53.85 16.92 56 134207 7603 110447433
Medication error 53.82 16.92 262 134001 105104 110349932
Acute respiratory failure 53.04 16.92 13 134250 75247 110379789
Plasma cell myeloma 52.70 16.92 7 134256 62929 110392107
Drug reaction with eosinophilia and systemic symptoms 52.63 16.92 17 134246 82078 110372958
Blood pressure fluctuation 52.59 16.92 13 134250 74811 110380225
Red blood cell count decreased 51.39 16.92 9 134254 65914 110389122
Accidental death 51.15 16.92 45 134218 4964 110450072
Toxic epidermal necrolysis 50.77 16.92 5 134258 56722 110398314
Creatinine renal clearance increased 50.49 16.92 39 134224 3586 110451450
Anaphylactic shock 50.48 16.92 3 134260 51543 110403493
Disease recurrence 50.33 16.92 7 134256 60777 110394259
Abdominal distension 49.73 16.92 85 134178 175018 110280018
Flushing 49.68 16.92 33 134230 104703 110350333
Heart rate increased 49.52 16.92 61 134202 143773 110311263
Sleep disorder due to a general medical condition 48.99 16.92 157 134106 51955 110403081
Colitis 48.86 16.92 32 134231 102291 110352745
Cerebral haemorrhage 48.24 16.92 10 134253 64958 110390078
Insomnia 47.27 16.92 656 133607 359934 110095102
Injection site pruritus 47.27 16.92 4 134259 51254 110403782
Burning sensation 46.79 16.92 13 134250 69199 110385837
Drug ineffective for unapproved indication 46.66 16.92 34 134229 102804 110352232
Colitis ulcerative 46.66 16.92 202 134061 77161 110377875
Heart rate decreased 46.62 16.92 21 134242 82735 110372301
Dysphonia 46.47 16.92 17 134246 75912 110379124
Pericardial effusion 46.42 16.92 7 134256 57210 110397826
Jaundice 46.36 16.92 8 134255 59228 110395808
Clostridium difficile infection 45.61 16.92 5 134258 52124 110402912
Hot flush 45.40 16.92 12 134251 66024 110389012
Pneumonitis 45.39 16.92 18 134245 76513 110378523
Haemorrhage 44.96 16.92 38 134225 106654 110348382
Wrong technique in product usage process 44.95 16.92 25 134238 87323 110367713
Eczema 44.55 16.92 16 134247 72277 110382759
Laboratory test abnormal 44.39 16.92 136 134127 43943 110411093
Lactic acidosis 44.35 16.92 29 134234 92782 110362254
Vision blurred 44.12 16.92 55 134208 128967 110326069
Muscle spasms 44.04 16.92 524 133739 277633 110177403
Diabetes mellitus 43.62 16.92 34 134229 99347 110355689
Cataract 43.50 16.92 21 134242 79464 110375572
Hypothyroidism 43.48 16.92 17 134246 72882 110382154
Leukopenia 43.39 16.92 71 134192 148720 110306316
Lymphadenopathy 43.13 16.92 12 134251 63823 110391213
Respiratory distress 42.86 16.92 15 134248 68859 110386177
Renal disorder 42.65 16.92 5 134258 49474 110405562
Drug abuse 42.47 16.92 364 133899 177047 110277989
Coronary artery disease 42.29 16.92 17 134246 71673 110383363
Product prescribing error 42.29 16.92 6 134257 51325 110403711
Lymphocyte count decreased 42.11 16.92 9 134254 57234 110397802
Osteoporosis 41.88 16.92 213 134050 86939 110368097
Lip swelling 41.56 16.92 6 134257 50661 110404375
Clostridium difficile colitis 41.54 16.92 3 134260 43775 110411261
Swelling face 41.27 16.92 31 134232 92290 110362746
Cytomegalovirus infection 41.22 16.92 8 134255 54436 110400600
Mouth ulceration 41.16 16.92 5 134258 48133 110406903
Melaena 41.06 16.92 16 134247 68741 110386295
Candida infection 41.02 16.92 5 134258 48004 110407032
Therapy interrupted 40.63 16.92 6 134257 49816 110405220
Precancerous cells present 40.32 16.92 23 134240 1270 110453766
Acute myocardial infarction 40.27 16.92 26 134237 83751 110371285
Therapy cessation 40.02 16.92 4 134259 44853 110410183
Pulmonary hypertension 39.98 16.92 9 134254 55211 110399825
Blood alkaline phosphatase increased 39.96 16.92 18 134245 70917 110384119
Hypocalcaemia 39.39 16.92 15 134248 65351 110389685
Hyperglycaemia 38.77 16.92 28 134235 85062 110369974
Altered state of consciousness 38.62 16.92 11 134252 57615 110397421
Hepatic function abnormal 38.62 16.92 31 134232 89264 110365772
Rhabdomyolysis 38.43 16.92 54 134209 120347 110334689
Blood pressure decreased 38.38 16.92 50 134213 115041 110339995
Throat irritation 38.23 16.92 9 134254 53543 110401493
Influenza like illness 37.86 16.92 31 134232 88381 110366655
Pain in jaw 37.75 16.92 8 134255 51169 110403867
Pancreatitis acute 37.73 16.92 13 134250 60261 110394775
Paraesthesia 37.42 16.92 506 133757 276015 110179021
Lymphopenia 37.41 16.92 3 134260 40167 110414869
Gamma-glutamyltransferase increased 37.06 16.92 14 134249 61295 110393741
Haematuria 36.94 16.92 28 134235 82977 110372059
Dry eye 36.75 16.92 11 134252 55782 110399254
Sedation complication 36.54 16.92 77 134186 19778 110435258
Osteonecrosis of jaw 36.47 16.92 7 134256 48010 110407026
Eye injury 36.39 16.92 46 134217 7709 110447327
Angina pectoris 36.38 16.92 15 134248 62280 110392756
Dyspnoea 36.09 16.92 1046 133217 1105826 109349210
Dysuria 35.99 16.92 14 134249 60217 110394819
Transaminases increased 35.84 16.92 16 134247 63374 110391662
Renal function test abnormal 35.69 16.92 49 134214 8897 110446139
Haematocrit decreased 35.37 16.92 18 134245 66099 110388937
Fungal infection 35.37 16.92 9 134254 50797 110404239
Creatinine renal clearance decreased 34.93 16.92 80 134183 21735 110433301
Feeling abnormal 34.90 16.92 108 134155 180603 110274433
General symptom 34.61 16.92 48 134215 8798 110446238
Prostate cancer 34.54 16.92 3 134260 37638 110417398
Bacterial infection 34.36 16.92 7 134256 46029 110409007
Skin lesion 34.34 16.92 10 134253 51621 110403415
No adverse event 34.03 16.92 24 134239 73815 110381221
Gait disturbance 33.99 16.92 500 133763 277708 110177328
Frequent bowel movements 33.97 16.92 174 134089 71216 110383820
Injection site bruising 33.96 16.92 10 134253 51253 110403783
Presyncope 33.39 16.92 9 134254 48878 110406158
Hepatocellular injury 33.33 16.92 10 134253 50632 110404404
Palmar-plantar erythrodysaesthesia syndrome 33.32 16.92 5 134258 41020 110414016
Blood potassium decreased 33.31 16.92 12 134251 54102 110400934
Drug eruption 32.86 16.92 12 134251 53647 110401389
Haematoma 32.69 16.92 15 134248 58461 110396575
Vasculitis 32.53 16.92 3 134260 35870 110419166
Intestinal obstruction 32.43 16.92 12 134251 53215 110401821
Cytokine release syndrome 32.21 16.92 23 134240 70283 110384753
Blepharospasm 32.14 16.92 142 134121 54709 110400327
Unevaluable event 31.87 16.92 16 134247 59211 110395825
Hypophagia 31.83 16.92 12 134251 52614 110402422
Incorrect dose administered 31.59 16.92 48 134215 103593 110351443
Seronegative arthritis 31.43 16.92 57 134206 13120 110441916
Neoplasm malignant 31.41 16.92 4 134259 37139 110417897
Surgery 31.39 16.92 6 134257 41277 110413759
Hypercalcaemia 31.10 16.92 9 134254 46648 110408388
Blood urea increased 30.87 16.92 14 134249 54943 110400093
Palpitations 30.85 16.92 95 134168 159117 110295919
Transient ischaemic attack 30.55 16.92 20 134243 63962 110391074
Blindness 30.54 16.92 4 134259 36355 110418681
Back disorder 30.54 16.92 74 134189 20848 110434188
Hypokalaemia 30.51 16.92 116 134147 182332 110272704
Skin ulcer 30.25 16.92 20 134243 63625 110391411
Diabetic ketoacidosis 30.16 16.92 7 134256 42051 110412985
Face oedema 29.82 16.92 3 134260 33466 110421570
Myelodysplastic syndrome 29.47 16.92 5 134258 37479 110417557
Ocular hyperaemia 29.26 16.92 6 134257 39280 110415756
Suicidal ideation 29.12 16.92 43 134220 93894 110361142
COVID-19 pneumonia 29.10 16.92 5 134258 37138 110417898
Pustular psoriasis 28.90 16.92 56 134207 13549 110441487
Haematemesis 28.88 16.92 18 134245 59090 110395946
Hyperhidrosis 28.85 16.92 123 134140 187175 110267861
Hypervolaemia 28.73 16.92 12 134251 49448 110405588
Pneumonia aspiration 28.43 16.92 34 134229 81199 110373837
Neurotoxicity 28.39 16.92 8 134255 42199 110412837
Rash vesicular 28.34 16.92 58 134205 14594 110440442
Hepatic failure 28.33 16.92 25 134238 68714 110386322
Shock 28.06 16.92 15 134248 53573 110401463
Stevens-Johnson syndrome 27.86 16.92 11 134252 46890 110408146
Inappropriate antidiuretic hormone secretion 27.78 16.92 4 134259 33847 110421189
Neuralgia 27.78 16.92 12 134251 48466 110406570
Haemophagocytic lymphohistiocytosis 27.68 16.92 3 134260 31556 110423480
Metastases to bone 27.47 16.92 3 134260 31369 110423667
Dysgeusia 27.03 16.92 27 134236 69958 110385078
Blood lactate dehydrogenase increased 27 16.92 10 134253 44324 110410712
Device expulsion 26.93 16.92 3 134260 30888 110424148
Bacteraemia 26.78 16.92 9 134254 42381 110412655
Hyperbilirubinaemia 26.69 16.92 3 134260 30668 110424368
Osteomyelitis 26.43 16.92 6 134257 36594 110418442
Peritonitis 26.42 16.92 4 134259 32603 110422433
Diaphragmatic rupture 26.36 16.92 10 134253 213 110454823
Basal cell carcinoma 26.27 16.92 11 134252 45259 110409777
Blood sodium decreased 26.27 16.92 7 134256 38312 110416724
Encephalopathy 26.22 16.92 36 134227 81019 110374017
Proteinuria 26.16 16.92 8 134255 40010 110415026
Cardiogenic shock 25.95 16.92 19 134244 57319 110397717
Hallucination, visual 25.74 16.92 8 134255 39597 110415439
Hyperlipidaemia 25.64 16.92 6 134257 35842 110419194
Cardiac disorder 25.57 16.92 33 134230 76247 110378789
Skin laceration 25.47 16.92 5 134258 33748 110421288
Paraesthesia oral 25.38 16.92 5 134258 33666 110421370
Flatulence 25.31 16.92 16 134247 52133 110402903
Pulmonary mass 25.22 16.92 7 134256 37294 110417742
Metastases to liver 25.16 16.92 6 134257 35380 110419656
Eye irritation 25.14 16.92 5 134258 33447 110421589
Cerebral infarction 25.03 16.92 16 134247 51822 110403214
Thrombotic microangiopathy 24.99 16.92 3 134260 29146 110425890
Blood potassium increased 24.93 16.92 5 134258 33244 110421792
Rash macular 24.81 16.92 8 134255 38678 110416358
Listless 24.80 16.92 29 134234 4486 110450550
Hallucination 24.65 16.92 54 134209 101378 110353658
Acute myeloid leukaemia 24.23 16.92 8 134255 38102 110416934
Disseminated intravascular coagulation 24.01 16.92 10 134253 41276 110413760
Cytopenia 23.72 16.92 4 134259 30112 110424924
Aphasia 23.67 16.92 22 134241 58975 110396061
Oral pain 23.57 16.92 8 134255 37436 110417600
Intentional self-injury 23.55 16.92 8 134255 37421 110417615
Speech disorder 23.49 16.92 24 134239 61545 110393491
Procedural pain 23.45 16.92 7 134256 35558 110419478
Tubulointerstitial nephritis 23.28 16.92 19 134244 54265 110400771
Gastroenteritis 23.22 16.92 9 134254 38791 110416245
Pneumothorax 23.16 16.92 7 134256 35278 110419758
Dysarthria 22.82 16.92 42 134221 84079 110370957
Derailment 22.70 16.92 7 134256 77 110454959
Ulcer 22.68 16.92 12 134251 43104 110411932
Cholecystitis chronic 22.54 16.92 41 134222 9459 110445577
Neutrophil count increased 22.52 16.92 7 134256 34645 110420391
Stress 22.50 16.92 60 134203 105288 110349748
Lacrimation increased 22.50 16.92 5 134258 30945 110424091
Ischaemic stroke 22.43 16.92 11 134252 41252 110413784
Eye disorder 22.41 16.92 4 134259 28902 110426134
Device issue 22.40 16.92 7 134256 34528 110420508
Device related infection 22.30 16.92 10 134253 39509 110415527
Ejection fraction decreased 22.06 16.92 11 134252 40869 110414167
Blood test abnormal 22.03 16.92 4 134259 28550 110426486
Renal tubular necrosis 22.00 16.92 5 134258 30470 110424566
Neuroleptic malignant syndrome 21.92 16.92 7 134256 34052 110420984
Product administration error 21.67 16.92 9 134254 37208 110417828
Fatigue 21.65 16.92 1232 133031 1214726 109240310
Tendonitis 21.60 16.92 3 134260 26080 110428956
Electrolyte imbalance 21.48 16.92 9 134254 37019 110418017
Pseudomonas infection 21.28 16.92 4 134259 27849 110427187
Dermatitis 21.26 16.92 4 134259 27833 110427203
Localised infection 21.18 16.92 13 134250 43035 110412001
Gout 21.04 16.92 9 134254 36557 110418479
Device malfunction 21.02 16.92 3 134260 25555 110429481
Hepatitis 21.02 16.92 49 134214 90005 110365031
Lethargy 20.98 16.92 52 134211 93524 110361512
Sinus bradycardia 20.96 16.92 5 134258 29478 110425558
Transfusion 20.93 16.92 3 134260 25469 110429567
Subdural haematoma 20.93 16.92 9 134254 36445 110418591
Carbuncle 20.91 16.92 16 134247 1451 110453585
Nephropathy toxic 20.88 16.92 4 134259 27474 110427562
Pancreatitis 20.86 16.92 189 134074 93344 110361692
Accidental exposure to product 20.84 16.92 18 134245 49990 110405046
Multiple drug therapy 20.83 16.92 36 134227 7978 110447058
Pyelonephritis 20.69 16.92 3 134260 25247 110429789
Disturbance in attention 20.60 16.92 27 134236 61968 110393068
Leukocytosis 20.52 16.92 21 134242 53807 110401229
Nodule 20.49 16.92 7 134256 32624 110422412
Tumour lysis syndrome 20.42 16.92 6 134257 30795 110424241
Glomerular filtration rate decreased 20.41 16.92 5 134258 28951 110426085
Oral candidiasis 20.04 16.92 15 134248 44745 110410291
Conjunctivitis 19.95 16.92 8 134255 33784 110421252
Osteonecrosis 19.90 16.92 8 134255 33733 110421303
Joint injury 19.79 16.92 12 134251 39982 110415054
Hypertensive crisis 19.73 16.92 3 134260 24369 110430667
Dyskinesia 19.69 16.92 20 134243 51426 110403610
Hepatic encephalopathy 19.68 16.92 5 134258 28251 110426785
Hip fracture 19.67 16.92 9 134254 35142 110419894
Tachycardia 19.67 16.92 178 134085 226467 110228569
Coma 19.66 16.92 75 134188 117794 110337242
Urinary incontinence 19.63 16.92 18 134245 48569 110406467
Atrial flutter 19.61 16.92 3 134260 24259 110430777
Iron deficiency anaemia 19.42 16.92 7 134256 31552 110423484
Diabetes mellitus inadequate control 19.38 16.92 6 134257 29769 110425267
Loss of consciousness 19.37 16.92 149 134114 196157 110258879
Swollen tongue 19.33 16.92 27 134236 60335 110394701
Subarachnoid haemorrhage 19.30 16.92 6 134257 29696 110425340
Alcohol interaction 19.09 16.92 23 134240 3671 110451365
Visual impairment 19 16.92 248 134015 134180 110320856
Kidney infection 18.88 16.92 4 134259 25595 110429441
Blood pressure diastolic decreased 18.85 16.92 10 134253 35875 110419161
Diplopia 18.81 16.92 14 134249 41880 110413156
Feeling hot 18.77 16.92 181 134082 90925 110364111
Weight decreased 18.73 16.92 429 133834 467628 109987408
Neutropenic sepsis 18.61 16.92 7 134256 30739 110424297
Eye pain 18.59 16.92 20 134243 50079 110404957
Generalised oedema 18.57 16.92 7 134256 30697 110424339
Small intestinal obstruction 18.42 16.92 8 134255 32205 110422831
Body temperature decreased 18.39 16.92 11 134252 36924 110418112
Oesophagitis 18.31 16.92 6 134257 28709 110426327
Pollakiuria 18.30 16.92 16 134247 44179 110410857
Product substitution issue 18.30 16.92 3 134260 23058 110431978
Metastases to central nervous system 18.04 16.92 3 134260 22814 110432222
Upper respiratory tract infection 17.99 16.92 90 134173 131238 110323798
Ataxia 17.99 16.92 7 134256 30101 110424935
Bronchiectasis 17.98 16.92 11 134252 36482 110418554
Device dislocation 17.93 16.92 8 134255 31696 110423340
Tachypnoea 17.90 16.92 13 134250 39382 110415654
Viral infection 17.80 16.92 23 134240 53116 110401920
Hallucination, auditory 17.76 16.92 5 134258 26392 110428644
Red blood cell sedimentation rate abnormal 17.73 16.92 4 134259 24505 110430531
Skin infection 17.70 16.92 3 134260 22506 110432530
Immune thrombocytopenia 17.69 16.92 3 134260 22491 110432545
Reduced facial expression 17.68 16.92 22 134241 3629 110451407
Myoclonus 17.63 16.92 9 134254 32989 110422047
Blood pressure abnormal 17.61 16.92 3 134260 22421 110432615
Blood calcium decreased 17.49 16.92 88 134175 35757 110419279
Blood urine present 17.45 16.92 4 134259 24241 110430795
Tooth disorder 17.40 16.92 7 134256 29502 110425534
Pallor 17.35 16.92 26 134237 56441 110398595
Liver function test abnormal 17.34 16.92 36 134227 68914 110386122
Rash papular 17.23 16.92 6 134257 27633 110427403
Electrocardiogram QT prolonged 17.12 16.92 71 134192 108889 110346147
Normal newborn 17.09 16.92 62 134201 21834 110433202
Posterior reversible encephalopathy syndrome 16.98 16.92 10 134253 33851 110421185
Hypokinesia 16.97 16.92 3 134260 21823 110433213
Skin burning sensation 16.96 16.92 3 134260 21822 110433214

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX26 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
ATC N06BC01 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Xanthine derivatives
ATC V04CG30 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for gastric secretion
FDA CS M0023046 Xanthines
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D058915 Purinergic P1 Receptor Antagonists
FDA PE N0000175729 Central Nervous System Stimulation
FDA EPC N0000175739 Central Nervous System Stimulant
FDA EPC N0000175790 Methylxanthine
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:25435 mutagen
CHEBI has role CHEBI:35337 central nervous system stimulant
CHEBI has role CHEBI:35471 psychotropic drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35498 diuretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
CHEBI has role CHEBI:50514 vasoconstrictor agent
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:50925 EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
CHEBI has role CHEBI:53121 adenosine A<small><sub>2A</sub></small> receptor antagonist
CHEBI has role CHEBI:60809 adjuvant
CHEBI has role CHEBI:64047 food additive
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:67114 ryanodine receptor agonist
CHEBI has role CHEBI:71232 adenosine receptor antagonist
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:76946 fungal metabolite
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:85234 human blood serum metabolite
CHEBI has role CHEBI:176497 geroprotector
CHEBI has role CHEBI:55324 gastrointestinal drug

Related Drugs by ATC class:

D11AX Other dermatologicals 20 drugs
aminobenzoic acidbrimonidinecalcium gluconatedeoxycholic aciddiclofenaceflornithinefinasteridegamolenic acidhydrogen peroxidehydroquinoneivermectinlithium succinate show all 20 →
N06BC Xanthine derivatives 1 drug
propentofylline
V04CG Tests for gastric secretion 5 drugs
betazolehistaminemethylthioninium chloridepentagastrinsodium benzoate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Apnea in the newborn indication 13094009
Pain indication 22253000
Migraine indication 37796009 DOID:6364
Joint pain indication 57676002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Common cold indication 82272006 DOID:10459
Vascular headache indication 128187005
Backache indication 161891005
Cluster headache syndrome indication 193031009
Spasticity indication 221360009
Headache disorder indication 230461009
Dysmenorrhea indication 266599000
Influenza-like symptoms indication 315642008
Tension-type headache indication 398057008
Cluster Headache Prevention indication
Fatigue off-label use 84229001
Urinary incontinence off-label use 165232002
Obesity off-label use 414916001 DOID:9970
Brain damage contraindication 2470005
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypophosphatemia contraindication 4996001
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Acute cerebrovascular insufficiency contraindication 29322000
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Hyperactive behavior contraindication 44548000
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Retroperitoneal fibrosis contraindication 49120005
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Fibrosis of lung contraindication 51615001 DOID:3770
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Gastrectomy contraindication 53442002
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Thrombophlebitis contraindication 64156001 DOID:3875
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Hypermagnesemia contraindication 66978005
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hemorrhoids contraindication 70153002 DOID:9746
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Atrophic gastritis contraindication 84568007 DOID:8929
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Chronic renal failure syndrome contraindication 90688005
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Obstruction of duodenum contraindication 95532008 DOID:3558
Disorder of biliary tract contraindication 105997008 DOID:9741
Anemia due to enzyme deficiency contraindication 111577008
Prolonged QT interval contraindication 111975006
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Prolonged PR interval contraindication 164947007
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Myocardial dysfunction contraindication 233928007
Peripheral ischemia contraindication 233958001
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Hyporeninemic hypoaldosteronism contraindication 236464008
Aluminum intoxication contraindication 236546003
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Pyloric obstruction contraindication 244815007
Sleep automatism contraindication 247962006
Raynaud's phenomenon contraindication 266261006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Exacerbation of asthma contraindication 281239006
Cerebral ischemia contraindication 287731003
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Peripheral vascular disease contraindication 400047006
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Fibrosis of pleura contraindication 442110002
Congenital long QT syndrome contraindication 442917000
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Smokes tobacco daily contraindication 449868002
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Ergot Alkaloid Toxicity contraindication
Acute Thromboembolic Stroke contraindication
Organic Cardiac Disease contraindication
Severe Pruritus contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Adenosine receptor A2b GPCR ANTAGONIST Ki 4.77 WOMBAT-PK CHEMBL
Adenosine receptor A1 GPCR ANTAGONIST Ki 4.97 IUPHAR CHEMBL
Adenosine receptor A2a GPCR ANTAGONIST Ki 5.61 CHEMBL CHEMBL
Acetylcholinesterase Enzyme IC50 5.14 CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Kinase IC50 4.12 CHEMBL
NAD-dependent deacetylase sirtuin 3 Enzyme Kd 6.16 CHEMBL
Guanine deaminase Enzyme Ki 4.99 CHEMBL
Nuclear receptor subfamily 2 group E member 1 Nuclear hormone receptor IC50 5.10 CHEMBL
Palmitoleoyl-protein carboxylesterase NOTUM Enzyme IC50 4.73 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.31 CHEMBL
Adenosine receptor A3 GPCR ANTAGONIST Ki 4.33 WOMBAT-PK
Glycogen phosphorylase, muscle form Enzyme IC50 4.13 CHEMBL
Adenosine receptor A1 GPCR Ki 4.77 CHEMBL
Adenosine receptor A2a GPCR Ki 5.03 CHEMBL
Adenosine receptor A1 GPCR Ki 4.54 CHEMBL
Adenosine receptor A1 GPCR Ki 4 CHEMBL
Adenosine A2 receptor GPCR Ki 4.57 CHEMBL
Adenosine receptor GPCR Ki 4.22 CHEMBL
Adenosine A2a receptor GPCR Ki 4.10 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Ion channel EC50 4.21 CHEMBL
Adenosine receptor A2b GPCR ANTAGONIST Ki 4.89 IUPHAR
Transient receptor potential cation channel subfamily A member 1 Ion channel EC50 4.02 CHEMBL

External reference:

IDSource
4017537 VUID
N0000145919 NUI
D00528 KEGG_DRUG
69-22-7 SECONDARY_CAS_RN
1886 RXNORM
C0006644 UMLSCUI
CHEBI:27732 CHEBI
CFF PDB_CHEM_ID
CHEMBL113 ChEMBL_ID
DB00201 DRUGBANK_ID
CHEMBL1200569 ChEMBL_ID
D002110 MESH_DESCRIPTOR_UI
2519 PUBCHEM_CID
407 IUPHAR_LIGAND_ID
C026189 MESH_SUPPLEMENTAL_RECORD_UI
3G6A5W338E UNII
11623 MMSL
17093 MMSL
4318 MMSL
4319 MMSL
46084 MMSL
4939 MMSL
d00801 MMSL
1269198007 SNOMEDCT_US
23068001 SNOMEDCT_US
255641001 SNOMEDCT_US
91107009 SNOMEDCT_US
4017537 VANDF
4018995 VANDF
000600 NDDF
000601 NDDF
3G6A5W338E INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0054-0650 CAPSULE 40 mg ORAL ANDA 33 sections
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0054-3000 CAPSULE 40 mg ORAL ANDA 33 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 13 sections
Excedrin Extra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 15 sections
Excedrin Extra Strength Headache HUMAN OTC DRUG LABEL 3 0067-2002 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 15 sections
Excedrin Extra Strength Headache HUMAN OTC DRUG LABEL 3 0067-2003 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 15 sections
ExcedrinExtra Strength Geltabs HUMAN OTC DRUG LABEL 3 0067-2021 TABLET, COATED 65 mg ORAL OTC Monograph Drug 14 sections
Excedrin Migraine Geltabs HUMAN OTC DRUG LABEL 3 0067-2035 TABLET, COATED 65 mg ORAL NDA 14 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 65 mg ORAL NDA 15 sections
ExcedrinMigraine HUMAN OTC DRUG LABEL 3 0067-2040 TABLET, FILM COATED 65 mg ORAL NDA 16 sections
ExcedrinMigraine Relief HUMAN OTC DRUG LABEL 3 0067-2042 TABLET, FILM COATED 65 mg ORAL NDA 15 sections
ExcedrinTension Headache HUMAN OTC DRUG LABEL 2 0067-8139 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 15 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 65 mg ORAL NDA 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 15 sections
Excedrin Extra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8203 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 65 mg ORAL ANDA 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-1619 TABLET, FILM COATED 65 mg ORAL ANDA 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-1619 TABLET, FILM COATED 65 mg ORAL ANDA 15 sections
good sense headache relief HUMAN OTC DRUG LABEL 3 0113-1855 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 15 sections
PANADOL Extra HUMAN OTC DRUG LABEL 2 0135-0620 TABLET, FILM COATED 65 mg ORAL OTC Monograph Drug 16 sections
Butalbital, Acetaminophen, and Caffeine HUMAN PRESCRIPTION DRUG LABEL 3 0143-0170 CAPSULE 40 mg ORAL ANDA 26 sections
ERGOTAMINE HUMAN PRESCRIPTION DRUG LABEL 2 0143-2120 TABLET, FILM COATED 100 mg ORAL ANDA 22 sections
Bayer Headache HUMAN OTC DRUG LABEL 2 0280-0064 TABLET 32.50 mg ORAL OTC Monograph Drug 14 sections
Alka-Seltzer Hangover Relief HUMAN OTC DRUG LABEL 2 0280-0084 TABLET, EFFERVESCENT 65 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Hangover Relief HUMAN OTC DRUG LABEL 2 0280-0084 TABLET, EFFERVESCENT 65 mg ORAL OTC Monograph Drug 16 sections
Bayer Rapid Relief HUMAN OTC DRUG LABEL 2 0280-0103 POWDER 65 mg ORAL OTC Monograph Drug 10 sections
Aspirina Cafeina HUMAN OTC DRUG LABEL 2 0280-0162 TABLET 32.50 mg ORAL OTC Monograph Drug 15 sections
Bayer Back and BodyExtra Strength HUMAN OTC DRUG LABEL 2 0280-2150 TABLET 35.50 mg ORAL OTC Monograph Drug 15 sections
Midol Complete HUMAN OTC DRUG LABEL 3 0280-8005 TABLET 60 mg ORAL OTC Monograph Drug 17 sections
Midol CompleteGelcaps HUMAN OTC DRUG LABEL 3 0280-8015 TABLET, COATED 60 mg ORAL OTC Monograph Drug 16 sections