Stem definition | Drug id | CAS RN |
---|---|---|
463 | 58-08-2 |
Dose | Unit | Route |
---|---|---|
0.40 | g | O |
0.40 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 21.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 51.77 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 98 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.63 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.64 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 4.90 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 26, 1948 | FDA | NOVARTIS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2406.36 | 9.83 | 3633 | 334399 | 128256 | 50138836 |
Toxicity to various agents | 2015.12 | 9.83 | 4404 | 333628 | 208095 | 50058997 |
Infusion related reaction | 833.11 | 9.83 | 2758 | 335274 | 166799 | 50100293 |
Sinusitis | 623.43 | 9.83 | 2521 | 335511 | 168037 | 50099055 |
Muscle injury | 545.57 | 9.83 | 928 | 337104 | 36183 | 50230909 |
Folliculitis | 540.25 | 9.83 | 953 | 337079 | 38272 | 50228820 |
Exposure to toxic agent | 517.44 | 9.83 | 316 | 337716 | 3342 | 50263750 |
Acute hepatic failure | 483.95 | 9.83 | 560 | 337472 | 15117 | 50251975 |
Irritable bowel syndrome | 462.76 | 9.83 | 1046 | 336986 | 50395 | 50216697 |
Lower respiratory tract infection | 457.43 | 9.83 | 1538 | 336494 | 93663 | 50173429 |
Overdose | 452.84 | 9.83 | 1581 | 336451 | 98146 | 50168946 |
Blister | 363.61 | 9.83 | 1326 | 336706 | 84092 | 50183000 |
Sleep disorder due to general medical condition, insomnia type | 361.47 | 9.83 | 707 | 337325 | 30740 | 50236352 |
Ill-defined disorder | 352.34 | 9.83 | 979 | 337053 | 53675 | 50213417 |
Intentional product misuse | 342.58 | 9.83 | 878 | 337154 | 45856 | 50221236 |
Metabolic acidosis | 338.64 | 9.83 | 780 | 337252 | 38045 | 50229047 |
Blood pressure fluctuation | 335.10 | 9.83 | 740 | 337292 | 35083 | 50232009 |
Product dose omission issue | 321.15 | 9.83 | 456 | 337576 | 183382 | 50083710 |
Duodenal ulcer perforation | 307.90 | 9.83 | 831 | 337201 | 44780 | 50222312 |
Impaired healing | 300.89 | 9.83 | 1088 | 336944 | 68698 | 50198394 |
Helicobacter infection | 299.59 | 9.83 | 869 | 337163 | 48833 | 50218259 |
Anti-cyclic citrullinated peptide antibody positive | 297.18 | 9.83 | 1092 | 336940 | 69495 | 50197597 |
Pericarditis | 276.57 | 9.83 | 1150 | 336882 | 77539 | 50189553 |
Joint swelling | 265.56 | 9.83 | 2653 | 335379 | 242633 | 50024459 |
Injection site pain | 264.56 | 9.83 | 212 | 337820 | 110812 | 50156280 |
Hepatic enzyme increased | 259.93 | 9.83 | 1689 | 336343 | 135691 | 50131401 |
Rheumatoid arthritis | 238.43 | 9.83 | 2230 | 335802 | 200320 | 50066772 |
Nasopharyngitis | 234.61 | 9.83 | 2139 | 335893 | 190788 | 50076304 |
Therapeutic product effect decreased | 224.85 | 9.83 | 1618 | 336414 | 134432 | 50132660 |
Hepatotoxicity | 217.87 | 9.83 | 529 | 337503 | 26697 | 50240395 |
Diarrhoea | 210.75 | 9.83 | 2722 | 335310 | 585754 | 49681338 |
Gastrointestinal disorder | 206.74 | 9.83 | 1206 | 336826 | 93250 | 50173842 |
Anion gap | 197.01 | 9.83 | 112 | 337920 | 1025 | 50266067 |
Stomatitis | 189.77 | 9.83 | 1243 | 336789 | 100101 | 50166991 |
Body temperature increased | 179.30 | 9.83 | 538 | 337494 | 30803 | 50236289 |
Intentional overdose | 174.93 | 9.83 | 854 | 337178 | 61650 | 50205442 |
Hypersensitivity | 171.31 | 9.83 | 2192 | 335840 | 212969 | 50054123 |
Hand deformity | 169.74 | 9.83 | 1199 | 336833 | 99000 | 50168092 |
Synovitis | 167.39 | 9.83 | 1406 | 336626 | 122459 | 50144633 |
Medication error | 165.94 | 9.83 | 575 | 337457 | 35529 | 50231563 |
Discomfort | 164.82 | 9.83 | 1264 | 336768 | 107116 | 50159976 |
Intentional product use issue | 164.35 | 9.83 | 976 | 337056 | 75942 | 50191150 |
Weight increased | 161.63 | 9.83 | 2059 | 335973 | 199832 | 50067260 |
Psoriasis | 159.07 | 9.83 | 136 | 337896 | 68864 | 50198228 |
Swelling | 156.75 | 9.83 | 2039 | 335993 | 198833 | 50068259 |
Device expulsion | 156.01 | 9.83 | 9 | 338023 | 28813 | 50238279 |
Depressed level of consciousness | 152.72 | 9.83 | 720 | 337312 | 51233 | 50215859 |
Injection site erythema | 146.05 | 9.83 | 171 | 337861 | 74765 | 50192327 |
Wound | 138.74 | 9.83 | 1193 | 336839 | 104601 | 50162491 |
Wrong technique in product usage process | 135.97 | 9.83 | 103 | 337929 | 55407 | 50211685 |
Respiratory arrest | 131.93 | 9.83 | 471 | 337561 | 29538 | 50237554 |
Peripheral swelling | 129.62 | 9.83 | 2013 | 336019 | 203923 | 50063169 |
Coagulopathy | 127.19 | 9.83 | 333 | 337699 | 17611 | 50249481 |
Sedation complication | 127.16 | 9.83 | 218 | 337814 | 8548 | 50258544 |
Injection site reaction | 124.91 | 9.83 | 91 | 337941 | 49941 | 50217151 |
Hepatic cytolysis | 124.83 | 9.83 | 207 | 337825 | 7896 | 50259196 |
Heart rate decreased | 120.86 | 9.83 | 524 | 337508 | 35973 | 50231119 |
Ear pain | 120.16 | 9.83 | 439 | 337593 | 27844 | 50239248 |
Drug hypersensitivity | 115.65 | 9.83 | 1095 | 336937 | 249915 | 50017177 |
Cardio-respiratory arrest | 112.64 | 9.83 | 680 | 337352 | 53212 | 50213880 |
Analgesic drug level increased | 112.46 | 9.83 | 93 | 337939 | 1638 | 50265454 |
Hepatic failure | 107.28 | 9.83 | 464 | 337568 | 31819 | 50235273 |
Creatinine renal clearance decreased | 107.21 | 9.83 | 242 | 337790 | 11639 | 50255453 |
Confusional state | 106.33 | 9.83 | 1789 | 336243 | 184139 | 50082953 |
Anaemia | 106.03 | 9.83 | 1126 | 336906 | 251330 | 50015762 |
Blood pressure diastolic abnormal | 103.36 | 9.83 | 207 | 337825 | 9154 | 50257938 |
Infusion site pain | 103.19 | 9.83 | 244 | 337788 | 12102 | 50254990 |
Muscle spasticity | 102.09 | 9.83 | 299 | 337733 | 16885 | 50250207 |
Injection site pruritus | 100.23 | 9.83 | 74 | 337958 | 40337 | 50226755 |
Rheumatoid factor positive | 99.08 | 9.83 | 621 | 337411 | 49238 | 50217854 |
Infection | 95.55 | 9.83 | 1655 | 336377 | 171299 | 50095793 |
Cardiac failure congestive | 95.06 | 9.83 | 270 | 337762 | 84112 | 50182980 |
Poisoning | 94.66 | 9.83 | 237 | 337795 | 12192 | 50254900 |
Infusion site swelling | 94.44 | 9.83 | 171 | 337861 | 7005 | 50260087 |
Neutropenia | 91.64 | 9.83 | 595 | 337437 | 147370 | 50119722 |
Pruritus | 91.59 | 9.83 | 2511 | 335521 | 281057 | 49986035 |
Hospitalisation | 90.85 | 9.83 | 199 | 337833 | 67738 | 50199354 |
Disease progression | 90.41 | 9.83 | 332 | 337700 | 95534 | 50171558 |
Injection site bruising | 90.32 | 9.83 | 68 | 337964 | 36700 | 50230392 |
Sopor | 89.60 | 9.83 | 13 | 338019 | 19866 | 50247226 |
Blood calcium decreased | 87.62 | 9.83 | 321 | 337711 | 20385 | 50246707 |
Acute lung injury | 84.63 | 9.83 | 72 | 337960 | 1321 | 50265771 |
Myocardial infarction | 83.51 | 9.83 | 309 | 337723 | 88718 | 50178374 |
Hepatic necrosis | 83.45 | 9.83 | 136 | 337896 | 5112 | 50261980 |
Blood pressure systolic abnormal | 83.40 | 9.83 | 169 | 337863 | 7537 | 50259555 |
Therapy cessation | 82.70 | 9.83 | 35 | 337997 | 25976 | 50241116 |
Blood pressure diastolic decreased | 82.14 | 9.83 | 273 | 337759 | 16508 | 50250584 |
Drug resistance | 79.84 | 9.83 | 15 | 338017 | 18974 | 50248118 |
Respiratory depression | 79.18 | 9.83 | 217 | 337815 | 11793 | 50255299 |
Osteonecrosis of jaw | 78.82 | 9.83 | 61 | 337971 | 32465 | 50234627 |
Neuropathy peripheral | 78.74 | 9.83 | 355 | 337677 | 96402 | 50170690 |
Oxygen saturation decreased | 78.38 | 9.83 | 791 | 337241 | 72457 | 50194635 |
Glossodynia | 78.15 | 9.83 | 1144 | 336888 | 114425 | 50152667 |
Blood pressure increased | 77.52 | 9.83 | 1285 | 336747 | 131847 | 50135245 |
Cognitive disorder | 77.00 | 9.83 | 532 | 337500 | 43591 | 50223501 |
Drug ineffective | 75.68 | 9.83 | 4595 | 333437 | 814738 | 49452354 |
Infusion site extravasation | 75.51 | 9.83 | 153 | 337879 | 6823 | 50260269 |
Injection site swelling | 75.44 | 9.83 | 101 | 337931 | 41672 | 50225420 |
Suspected suicide | 73.50 | 9.83 | 130 | 337902 | 5227 | 50261865 |
Therapeutic product effect incomplete | 73.13 | 9.83 | 338 | 337694 | 91177 | 50175915 |
Arthropathy | 70.33 | 9.83 | 1462 | 336570 | 156444 | 50110648 |
Decreased appetite | 69.40 | 9.83 | 935 | 337097 | 199988 | 50067104 |
Infusion site erythema | 69.20 | 9.83 | 169 | 337863 | 8558 | 50258534 |
Dizziness | 67.87 | 9.83 | 1778 | 336254 | 344591 | 49922501 |
Product quality issue | 67.30 | 9.83 | 64 | 337968 | 30794 | 50236298 |
Exposure via ingestion | 66.92 | 9.83 | 88 | 337944 | 2715 | 50264377 |
Cardiac failure | 66.77 | 9.83 | 271 | 337761 | 75769 | 50191323 |
Pyroglutamate increased | 66.45 | 9.83 | 39 | 337993 | 381 | 50266711 |
Malignant neoplasm progression | 66.16 | 9.83 | 233 | 337799 | 67891 | 50199201 |
Blood pressure systolic increased | 65.79 | 9.83 | 434 | 337598 | 35015 | 50232077 |
Nausea | 63.26 | 9.83 | 3966 | 334066 | 701432 | 49565660 |
Feeling abnormal | 63.15 | 9.83 | 535 | 337497 | 124957 | 50142135 |
Contraindicated product administered | 63.04 | 9.83 | 1369 | 336663 | 147589 | 50119503 |
Throat irritation | 62.81 | 9.83 | 381 | 337651 | 29858 | 50237234 |
Orthostatic hypotension | 61.59 | 9.83 | 372 | 337660 | 29109 | 50237983 |
Night sweats | 61.08 | 9.83 | 409 | 337623 | 33165 | 50233927 |
No adverse event | 60.83 | 9.83 | 81 | 337951 | 33497 | 50233595 |
Pemphigus | 60.35 | 9.83 | 1133 | 336899 | 119033 | 50148059 |
Muscle spasms | 57.60 | 9.83 | 548 | 337484 | 125005 | 50142087 |
Sedation | 57.56 | 9.83 | 376 | 337656 | 30234 | 50236858 |
Coma | 56.01 | 9.83 | 604 | 337428 | 56275 | 50210817 |
Infusion site pruritus | 55.91 | 9.83 | 97 | 337935 | 3840 | 50263252 |
Rheumatic fever | 55.70 | 9.83 | 242 | 337790 | 16625 | 50250467 |
Cerebrovascular accident | 55.45 | 9.83 | 387 | 337645 | 94293 | 50172799 |
Interstitial lung disease | 54.96 | 9.83 | 177 | 337855 | 52999 | 50214093 |
Bone marrow failure | 54.93 | 9.83 | 62 | 337970 | 27562 | 50239530 |
Arthralgia | 54.73 | 9.83 | 3512 | 334520 | 435190 | 49831902 |
Liver injury | 54.38 | 9.83 | 317 | 337715 | 24489 | 50242603 |
Electric shock | 54.16 | 9.83 | 49 | 337983 | 979 | 50266113 |
Pyrexia | 53.25 | 9.83 | 3075 | 334957 | 377128 | 49889964 |
Product storage error | 52.81 | 9.83 | 9 | 338023 | 12215 | 50254877 |
Surgery | 52.57 | 9.83 | 75 | 337957 | 30130 | 50236962 |
Drug interaction | 52.13 | 9.83 | 979 | 337053 | 198642 | 50068450 |
Respiratory disorder | 52.05 | 9.83 | 372 | 337660 | 30815 | 50236277 |
Pyroglutamic acidosis | 51.97 | 9.83 | 34 | 337998 | 409 | 50266683 |
Heart rate increased | 51.92 | 9.83 | 764 | 337268 | 76486 | 50190606 |
Pancytopenia | 51.43 | 9.83 | 339 | 337693 | 83691 | 50183401 |
Paraesthesia | 51.32 | 9.83 | 534 | 337498 | 119709 | 50147383 |
Mucosal inflammation | 50.89 | 9.83 | 121 | 337911 | 40021 | 50227071 |
Contusion | 50.68 | 9.83 | 1041 | 336991 | 111142 | 50155950 |
Oedema peripheral | 49.61 | 9.83 | 749 | 337283 | 157212 | 50109880 |
Product substitution issue | 49.59 | 9.83 | 16 | 338016 | 14041 | 50253051 |
White blood cell count decreased | 49.56 | 9.83 | 519 | 337513 | 116203 | 50150889 |
Unevaluable event | 49.25 | 9.83 | 151 | 337881 | 45915 | 50221177 |
Epistaxis | 48.87 | 9.83 | 240 | 337792 | 63714 | 50203378 |
Red blood cell sedimentation rate abnormal | 48.82 | 9.83 | 24 | 338008 | 16319 | 50250773 |
Swollen joint count increased | 48.81 | 9.83 | 213 | 337819 | 14660 | 50252432 |
Injection site warmth | 48.54 | 9.83 | 16 | 338016 | 13850 | 50253242 |
Palmar-plantar erythrodysaesthesia syndrome | 48.30 | 9.83 | 38 | 337994 | 20060 | 50247032 |
Rash | 47.47 | 9.83 | 3462 | 334570 | 434009 | 49833083 |
Injection site rash | 46.47 | 9.83 | 25 | 338007 | 16152 | 50250940 |
Psoriatic arthropathy | 46.24 | 9.83 | 160 | 337872 | 46872 | 50220220 |
Memory impairment | 46.16 | 9.83 | 325 | 337707 | 79035 | 50188057 |
Posterior reversible encephalopathy syndrome | 46.01 | 9.83 | 21 | 338011 | 14907 | 50252185 |
Device malfunction | 45.48 | 9.83 | 22 | 338010 | 15099 | 50251993 |
Body temperature decreased | 45.11 | 9.83 | 223 | 337809 | 16172 | 50250920 |
Diabetes mellitus | 44.78 | 9.83 | 172 | 337860 | 48861 | 50218231 |
Crystal urine present | 44.39 | 9.83 | 52 | 337980 | 1422 | 50265670 |
Device dislocation | 44.34 | 9.83 | 47 | 337985 | 21499 | 50245593 |
Dyspnoea exertional | 44.09 | 9.83 | 184 | 337848 | 51049 | 50216043 |
Anion gap abnormal | 43.94 | 9.83 | 28 | 338004 | 321 | 50266771 |
Malaise | 43.87 | 9.83 | 1814 | 336218 | 333718 | 49933374 |
Neoplasm progression | 43.60 | 9.83 | 80 | 337952 | 29077 | 50238015 |
Heart rate irregular | 43.48 | 9.83 | 249 | 337783 | 19111 | 50247981 |
Renal impairment | 42.96 | 9.83 | 312 | 337720 | 75349 | 50191743 |
Infusion site bruising | 42.79 | 9.83 | 64 | 337968 | 2231 | 50264861 |
White blood cells urine positive | 42.14 | 9.83 | 94 | 337938 | 4484 | 50262608 |
Accidental overdose | 41.77 | 9.83 | 248 | 337784 | 19285 | 50247807 |
Hypotension | 41.33 | 9.83 | 1946 | 336086 | 233523 | 50033569 |
Underdose | 40.88 | 9.83 | 45 | 337987 | 20233 | 50246859 |
Device issue | 40.62 | 9.83 | 44 | 337988 | 19928 | 50247164 |
Injection site haemorrhage | 40.20 | 9.83 | 50 | 337982 | 21296 | 50245796 |
International normalised ratio increased | 40.08 | 9.83 | 453 | 337579 | 42699 | 50224393 |
Product prescribing error | 39.58 | 9.83 | 49 | 337983 | 20912 | 50246180 |
Suicide attempt | 39.35 | 9.83 | 523 | 337509 | 51209 | 50215883 |
Alanine aminotransferase increased | 39.27 | 9.83 | 818 | 337214 | 87541 | 50179551 |
Therapy interrupted | 39.23 | 9.83 | 46 | 337986 | 20106 | 50246986 |
Drug abuse | 38.70 | 9.83 | 588 | 337444 | 59258 | 50207834 |
Soft tissue disorder | 38.20 | 9.83 | 86 | 337946 | 4128 | 50262964 |
Systemic lupus erythematosus | 38.14 | 9.83 | 1219 | 336813 | 139403 | 50127689 |
Injection site urticaria | 37.95 | 9.83 | 17 | 338015 | 12200 | 50254892 |
Pneumonia | 37.75 | 9.83 | 2105 | 335927 | 376296 | 49890796 |
Acute kidney injury | 37.44 | 9.83 | 1199 | 336833 | 226859 | 50040233 |
Drug intolerance | 37.43 | 9.83 | 1806 | 336226 | 217298 | 50049794 |
Respiratory rate increased | 37.33 | 9.83 | 163 | 337869 | 11222 | 50255870 |
Injection site mass | 37.24 | 9.83 | 30 | 338002 | 15650 | 50251442 |
Substance abuse | 37.20 | 9.83 | 84 | 337948 | 4040 | 50263052 |
Mobility decreased | 36.80 | 9.83 | 744 | 337288 | 79204 | 50187888 |
Administration site swelling | 36.75 | 9.83 | 40 | 337992 | 1007 | 50266085 |
Urine abnormality | 36.53 | 9.83 | 108 | 337924 | 6130 | 50260962 |
Rash pruritic | 36.29 | 9.83 | 180 | 337852 | 47666 | 50219426 |
Blood parathyroid hormone decreased | 36.24 | 9.83 | 3 | 338029 | 7111 | 50259981 |
Lymphocyte count decreased | 36.21 | 9.83 | 300 | 337732 | 26007 | 50241085 |
Depression | 35.89 | 9.83 | 836 | 337196 | 164587 | 50102505 |
Myelodysplastic syndrome | 35.88 | 9.83 | 29 | 338003 | 15103 | 50251989 |
Hyperkalaemia | 35.85 | 9.83 | 182 | 337850 | 47907 | 50219185 |
Full blood count decreased | 35.52 | 9.83 | 59 | 337973 | 22287 | 50244805 |
Administration site pain | 35.51 | 9.83 | 32 | 338000 | 636 | 50266456 |
Device difficult to use | 35.33 | 9.83 | 11 | 338021 | 9875 | 50257217 |
Cardiac arrest | 35.10 | 9.83 | 768 | 337264 | 82883 | 50184209 |
Bone pain | 35.07 | 9.83 | 179 | 337853 | 47050 | 50220042 |
Drug ineffective for unapproved indication | 34.94 | 9.83 | 55 | 337977 | 21226 | 50245866 |
Product use in unapproved indication | 34.38 | 9.83 | 555 | 337477 | 115264 | 50151828 |
Jaundice cholestatic | 34.34 | 9.83 | 93 | 337939 | 5018 | 50262074 |
Abortion spontaneous | 34.12 | 9.83 | 153 | 337879 | 41619 | 50225473 |
Gastrooesophageal reflux disease | 33.59 | 9.83 | 337 | 337695 | 76091 | 50191001 |
Seizure | 33.30 | 9.83 | 570 | 337462 | 117304 | 50149788 |
Fall | 33.24 | 9.83 | 1864 | 336168 | 333068 | 49934024 |
Myelosuppression | 33.19 | 9.83 | 25 | 338007 | 13492 | 50253600 |
Poor venous access | 33.11 | 9.83 | 147 | 337885 | 10193 | 50256899 |
Blood pressure diastolic increased | 32.85 | 9.83 | 117 | 337915 | 7326 | 50259766 |
Infusion site nodule | 32.68 | 9.83 | 39 | 337993 | 1088 | 50266004 |
Off label use | 32.37 | 9.83 | 2729 | 335303 | 471697 | 49795395 |
Urinary sediment present | 32.21 | 9.83 | 52 | 337980 | 1939 | 50265153 |
Thrombocytopenia | 31.81 | 9.83 | 631 | 337401 | 127042 | 50140050 |
Urticaria | 30.79 | 9.83 | 1106 | 336926 | 128455 | 50138637 |
Blood pH decreased | 30.41 | 9.83 | 57 | 337975 | 2398 | 50264694 |
Red blood cells urine positive | 30.20 | 9.83 | 61 | 337971 | 2714 | 50264378 |
Dysgeusia | 29.75 | 9.83 | 146 | 337886 | 38770 | 50228322 |
Red cell distribution width increased | 29.18 | 9.83 | 124 | 337908 | 8435 | 50258657 |
Injection site induration | 28.85 | 9.83 | 10 | 338022 | 8387 | 50258705 |
Visual acuity reduced | 28.59 | 9.83 | 57 | 337975 | 20082 | 50247010 |
Neutrophil percentage increased | 28.56 | 9.83 | 59 | 337973 | 2668 | 50264424 |
Musculoskeletal disorder | 28.33 | 9.83 | 45 | 337987 | 17304 | 50249788 |
Hypomania | 28.32 | 9.83 | 80 | 337952 | 4425 | 50262667 |
Anion gap increased | 28.23 | 9.83 | 42 | 337990 | 1457 | 50265635 |
Pain | 28.16 | 9.83 | 4340 | 333692 | 574563 | 49692529 |
Suicidal ideation | 27.89 | 9.83 | 236 | 337796 | 55149 | 50211943 |
Dehydration | 27.84 | 9.83 | 790 | 337242 | 151659 | 50115433 |
Brain death | 27.73 | 9.83 | 59 | 337973 | 2724 | 50264368 |
Neonatal hypoxia | 27.39 | 9.83 | 24 | 338008 | 459 | 50266633 |
Coronary artery disease | 27.32 | 9.83 | 104 | 337928 | 29622 | 50237470 |
Accidental exposure to product | 27.28 | 9.83 | 72 | 337960 | 22985 | 50244107 |
Intervertebral discitis | 27.27 | 9.83 | 57 | 337975 | 2599 | 50264493 |
Body temperature fluctuation | 27.22 | 9.83 | 48 | 337984 | 1925 | 50265167 |
Vision blurred | 27.10 | 9.83 | 366 | 337666 | 78281 | 50188811 |
Dry skin | 27.05 | 9.83 | 173 | 337859 | 43018 | 50224074 |
Gait disturbance | 26.97 | 9.83 | 779 | 337253 | 149226 | 50117866 |
Full blood count abnormal | 26.94 | 9.83 | 74 | 337958 | 23314 | 50243778 |
Lymphocyte percentage decreased | 26.91 | 9.83 | 58 | 337974 | 2702 | 50264390 |
Transient ischaemic attack | 26.90 | 9.83 | 117 | 337915 | 32093 | 50234999 |
Multiple drug therapy | 26.57 | 9.83 | 47 | 337985 | 1890 | 50265202 |
Ageusia | 26.47 | 9.83 | 23 | 338009 | 11560 | 50255532 |
Brain oedema | 26.41 | 9.83 | 157 | 337875 | 12213 | 50254879 |
Urine leukocyte esterase positive | 26.32 | 9.83 | 59 | 337973 | 2824 | 50264268 |
Therapeutic response unexpected | 26.25 | 9.83 | 41 | 337991 | 15874 | 50251218 |
Fracture | 26.24 | 9.83 | 45 | 337987 | 16788 | 50250304 |
Myalgia | 26.19 | 9.83 | 631 | 337401 | 123688 | 50143404 |
Burning sensation | 25.99 | 9.83 | 187 | 337845 | 45259 | 50221833 |
Acidosis | 25.96 | 9.83 | 136 | 337896 | 10091 | 50257001 |
Ear pruritus | 25.69 | 9.83 | 54 | 337978 | 2472 | 50264620 |
Hypertensive crisis | 25.63 | 9.83 | 30 | 338002 | 13124 | 50253968 |
Multiple sclerosis relapse | 25.44 | 9.83 | 175 | 337857 | 42789 | 50224303 |
Hypercalcaemia | 25.35 | 9.83 | 76 | 337956 | 23276 | 50243816 |
Hyperlipidaemia | 25.26 | 9.83 | 49 | 337983 | 17441 | 50249651 |
Hyponatraemia | 25.21 | 9.83 | 471 | 337561 | 95668 | 50171424 |
Septic shock | 25.17 | 9.83 | 252 | 337780 | 56923 | 50210169 |
Platelet count decreased | 25.03 | 9.83 | 498 | 337534 | 100228 | 50166864 |
Diabetic ketoacidosis | 25.01 | 9.83 | 51 | 337981 | 17821 | 50249271 |
Sepsis | 24.73 | 9.83 | 687 | 337345 | 132238 | 50134854 |
Infusion site haemorrhage | 24.70 | 9.83 | 59 | 337973 | 2945 | 50264147 |
Liver transplant | 24.57 | 9.83 | 48 | 337984 | 2084 | 50265008 |
Incorrect drug administration rate | 24.54 | 9.83 | 54 | 337978 | 2552 | 50264540 |
Renal failure | 24.21 | 9.83 | 535 | 337497 | 106098 | 50160994 |
Analgesic drug level above therapeutic | 24.14 | 9.83 | 15 | 338017 | 164 | 50266928 |
Pneumocystis jirovecii pneumonia | 23.97 | 9.83 | 38 | 337994 | 14625 | 50252467 |
Drug-induced liver injury | 23.89 | 9.83 | 290 | 337742 | 27805 | 50239287 |
Breast cancer | 23.80 | 9.83 | 178 | 337854 | 42712 | 50224380 |
Pain in extremity | 23.78 | 9.83 | 1537 | 336495 | 271328 | 49995764 |
Leukopenia | 23.72 | 9.83 | 313 | 337719 | 67215 | 50199877 |
Foetal exposure during pregnancy | 23.69 | 9.83 | 98 | 337934 | 27261 | 50239831 |
Specific gravity urine decreased | 23.69 | 9.83 | 26 | 338006 | 661 | 50266431 |
Cytomegalovirus infection | 23.69 | 9.83 | 53 | 337979 | 17909 | 50249183 |
Joint stiffness | 23.57 | 9.83 | 113 | 337919 | 30195 | 50236897 |
Cytokine release syndrome | 23.44 | 9.83 | 117 | 337915 | 8517 | 50258575 |
Hepatic cirrhosis | 23.07 | 9.83 | 52 | 337980 | 17525 | 50249567 |
Haematotoxicity | 22.98 | 9.83 | 12 | 338020 | 7883 | 50259209 |
Dysphonia | 22.74 | 9.83 | 159 | 337873 | 38733 | 50228359 |
Lupus-like syndrome | 22.74 | 9.83 | 18 | 338014 | 9473 | 50257619 |
Disturbance in attention | 22.70 | 9.83 | 119 | 337913 | 31067 | 50236025 |
Blood cholesterol increased | 22.54 | 9.83 | 505 | 337527 | 54710 | 50212382 |
Bone erosion | 22.40 | 9.83 | 27 | 338005 | 11660 | 50255432 |
Genital haemorrhage | 22.29 | 9.83 | 8 | 338024 | 6566 | 50260526 |
Gastrointestinal haemorrhage | 22.20 | 9.83 | 350 | 337682 | 72971 | 50194121 |
Carpal tunnel syndrome | 22.15 | 9.83 | 50 | 337982 | 16843 | 50250249 |
Therapeutic response decreased | 22.13 | 9.83 | 205 | 337827 | 47026 | 50220066 |
Tremor | 22.11 | 9.83 | 591 | 337441 | 114312 | 50152780 |
Atrial fibrillation | 22.10 | 9.83 | 514 | 337518 | 101231 | 50165861 |
Prothrombin time prolonged | 22.07 | 9.83 | 117 | 337915 | 8721 | 50258371 |
Basal cell carcinoma | 21.93 | 9.83 | 81 | 337951 | 23275 | 50243817 |
Infusion site mass | 21.88 | 9.83 | 33 | 337999 | 1159 | 50265933 |
Aspartate aminotransferase increased | 21.88 | 9.83 | 679 | 337353 | 77319 | 50189773 |
Hypokalaemia | 21.87 | 9.83 | 435 | 337597 | 87557 | 50179535 |
Blood creatine increased | 21.72 | 9.83 | 77 | 337955 | 4810 | 50262282 |
Administration site erythema | 21.56 | 9.83 | 22 | 338010 | 513 | 50266579 |
Femur fracture | 21.50 | 9.83 | 154 | 337878 | 37310 | 50229782 |
Metastases to bone | 21.44 | 9.83 | 56 | 337976 | 17939 | 50249153 |
Metastases to liver | 21.41 | 9.83 | 66 | 337966 | 20038 | 50247054 |
Pulmonary hypertension | 21.36 | 9.83 | 133 | 337899 | 33284 | 50233808 |
Renal failure neonatal | 21.22 | 9.83 | 14 | 338018 | 171 | 50266921 |
Pathogen resistance | 20.93 | 9.83 | 6 | 338026 | 5683 | 50261409 |
Second primary malignancy | 20.89 | 9.83 | 10 | 338022 | 6904 | 50260188 |
Macular degeneration | 20.84 | 9.83 | 166 | 337866 | 14222 | 50252870 |
Respiratory failure | 20.83 | 9.83 | 457 | 337575 | 90724 | 50176368 |
Gestational diabetes | 20.77 | 9.83 | 12 | 338020 | 7453 | 50259639 |
Extrapyramidal disorder | 20.70 | 9.83 | 29 | 338003 | 11741 | 50255351 |
Disease recurrence | 20.63 | 9.83 | 67 | 337965 | 20014 | 50247078 |
Hypothermia | 20.44 | 9.83 | 144 | 337888 | 11872 | 50255220 |
Complication associated with device | 20.36 | 9.83 | 42 | 337990 | 14613 | 50252479 |
Syncope | 20.29 | 9.83 | 528 | 337504 | 102474 | 50164618 |
Polyneuropathy | 20.25 | 9.83 | 31 | 338001 | 12100 | 50254992 |
Ductus arteriosus premature closure | 20.11 | 9.83 | 17 | 338015 | 309 | 50266783 |
Epilepsy | 20.11 | 9.83 | 75 | 337957 | 21492 | 50245600 |
Infusion site urticaria | 20.06 | 9.83 | 29 | 338003 | 980 | 50266112 |
Aphasia | 20.03 | 9.83 | 110 | 337922 | 28384 | 50238708 |
Drug screen positive | 20.02 | 9.83 | 59 | 337973 | 3343 | 50263749 |
Body height decreased | 19.98 | 9.83 | 18 | 338014 | 8890 | 50258202 |
Haemorrhage | 19.77 | 9.83 | 245 | 337787 | 53196 | 50213896 |
C-reactive protein abnormal | 19.74 | 9.83 | 107 | 337925 | 27702 | 50239390 |
Angioedema | 19.67 | 9.83 | 159 | 337873 | 37517 | 50229575 |
Precancerous cells present | 19.59 | 9.83 | 32 | 338000 | 1205 | 50265887 |
Iron deficiency anaemia | 19.59 | 9.83 | 53 | 337979 | 16781 | 50250311 |
Laboratory test abnormal | 19.56 | 9.83 | 84 | 337948 | 23124 | 50243968 |
Respiratory tract congestion | 19.47 | 9.83 | 41 | 337991 | 14158 | 50252934 |
Panniculitis | 19.29 | 9.83 | 17 | 338015 | 8486 | 50258606 |
Osteonecrosis | 19.28 | 9.83 | 81 | 337951 | 22436 | 50244656 |
Palpitations | 19.27 | 9.83 | 482 | 337550 | 94024 | 50173068 |
Neurotoxicity | 19.02 | 9.83 | 44 | 337988 | 14696 | 50252396 |
Cardiomyopathy | 18.95 | 9.83 | 48 | 337984 | 15538 | 50251554 |
Skin necrosis | 18.89 | 9.83 | 27 | 338005 | 10840 | 50256252 |
Fluid retention | 18.82 | 9.83 | 232 | 337800 | 50417 | 50216675 |
Pulmonary arterial hypertension | 18.73 | 9.83 | 71 | 337961 | 20248 | 50246844 |
Spinal stenosis | 18.68 | 9.83 | 39 | 337993 | 13511 | 50253581 |
Cardiac disorder | 18.68 | 9.83 | 190 | 337842 | 42789 | 50224303 |
Hypocalcaemia | 18.59 | 9.83 | 104 | 337928 | 26712 | 50240380 |
Anxiety | 18.58 | 9.83 | 983 | 337049 | 176623 | 50090469 |
PCO2 decreased | 18.57 | 9.83 | 31 | 338001 | 1189 | 50265903 |
Blood urine present | 18.55 | 9.83 | 148 | 337884 | 12685 | 50254407 |
Right ventricular failure | 18.52 | 9.83 | 50 | 337982 | 15843 | 50251249 |
Loss of consciousness | 18.47 | 9.83 | 543 | 337489 | 103810 | 50163282 |
Taste disorder | 18.46 | 9.83 | 17 | 338015 | 8307 | 50258785 |
Dyspnoea | 18.30 | 9.83 | 3300 | 334732 | 544308 | 49722784 |
Blood glucose increased | 18.21 | 9.83 | 351 | 337681 | 70973 | 50196119 |
Intentional self-injury | 18.07 | 9.83 | 86 | 337946 | 23026 | 50244066 |
Osteoarthritis | 18.02 | 9.83 | 336 | 337696 | 68270 | 50198822 |
Inappropriate antidiuretic hormone secretion | 17.98 | 9.83 | 38 | 337994 | 13105 | 50253987 |
Febrile bone marrow aplasia | 17.77 | 9.83 | 10 | 338022 | 6301 | 50260791 |
Transplant rejection | 17.58 | 9.83 | 23 | 338009 | 9586 | 50257506 |
Smear cervix abnormal | 17.55 | 9.83 | 49 | 337983 | 2692 | 50264400 |
Temperature regulation disorder | 17.44 | 9.83 | 65 | 337967 | 4162 | 50262930 |
Haemolysis | 17.39 | 9.83 | 83 | 337949 | 5933 | 50261159 |
Product adhesion issue | 17.37 | 9.83 | 4 | 338028 | 4388 | 50262704 |
Hallucination, auditory | 17.35 | 9.83 | 28 | 338004 | 10700 | 50256392 |
Lactic acidosis | 17.30 | 9.83 | 141 | 337891 | 33214 | 50233878 |
Osmolar gap | 17.27 | 9.83 | 10 | 338022 | 95 | 50266997 |
Withdrawal syndrome | 17.18 | 9.83 | 60 | 337972 | 17530 | 50249562 |
COVID-19 immunisation | 17.16 | 9.83 | 23 | 338009 | 723 | 50266369 |
Infusion site irritation | 17.10 | 9.83 | 21 | 338011 | 604 | 50266488 |
Lung neoplasm malignant | 17.09 | 9.83 | 50 | 337982 | 15434 | 50251658 |
Bacterial test | 17.08 | 9.83 | 29 | 338003 | 1128 | 50265964 |
Abdominal distension | 17.05 | 9.83 | 364 | 337668 | 72539 | 50194553 |
Oral discomfort | 17.05 | 9.83 | 17 | 338015 | 8000 | 50259092 |
Post procedural pulmonary embolism | 17.00 | 9.83 | 14 | 338018 | 245 | 50266847 |
Injection site discolouration | 16.99 | 9.83 | 13 | 338019 | 6961 | 50260131 |
Bursitis | 16.92 | 9.83 | 224 | 337808 | 21911 | 50245181 |
Blood creatinine decreased | 16.89 | 9.83 | 72 | 337960 | 4904 | 50262188 |
Mean cell haemoglobin concentration increased | 16.64 | 9.83 | 18 | 338014 | 450 | 50266642 |
Tinnitus | 16.45 | 9.83 | 115 | 337917 | 28017 | 50239075 |
Thrombosis | 16.41 | 9.83 | 268 | 337764 | 55565 | 50211527 |
Chronic kidney disease | 16.40 | 9.83 | 178 | 337854 | 39593 | 50227499 |
Anaphylactic shock | 16.35 | 9.83 | 74 | 337958 | 20081 | 50247011 |
Meniscus injury | 16.34 | 9.83 | 11 | 338021 | 6291 | 50260801 |
Pericardial effusion | 16.28 | 9.83 | 102 | 337930 | 25487 | 50241605 |
Swollen tongue | 16.27 | 9.83 | 118 | 337914 | 28512 | 50238580 |
Renal papillary necrosis | 16.25 | 9.83 | 13 | 338019 | 218 | 50266874 |
Pain in jaw | 16.24 | 9.83 | 171 | 337861 | 38257 | 50228835 |
Hyperglycaemia | 16.21 | 9.83 | 160 | 337872 | 36245 | 50230847 |
Sensitivity to weather change | 16.20 | 9.83 | 10 | 338022 | 5991 | 50261101 |
Chest pain | 16.14 | 9.83 | 992 | 337040 | 175890 | 50091202 |
Complication of device removal | 16.06 | 9.83 | 4 | 338028 | 4160 | 50262932 |
Acute myocardial infarction | 15.99 | 9.83 | 122 | 337910 | 29151 | 50237941 |
Bradypnoea | 15.93 | 9.83 | 51 | 337981 | 3023 | 50264069 |
Heavy menstrual bleeding | 15.85 | 9.83 | 52 | 337980 | 15485 | 50251607 |
Gout | 15.82 | 9.83 | 33 | 337999 | 11437 | 50255655 |
Akathisia | 15.79 | 9.83 | 19 | 338013 | 8210 | 50258882 |
Skin exfoliation | 15.70 | 9.83 | 146 | 337886 | 33466 | 50233626 |
Infusion site discomfort | 15.68 | 9.83 | 24 | 338008 | 854 | 50266238 |
Rhinitis allergic | 15.62 | 9.83 | 15 | 338017 | 7185 | 50259907 |
Haemophagocytic lymphohistiocytosis | 15.46 | 9.83 | 21 | 338011 | 8612 | 50258480 |
Hepatitis cholestatic | 15.29 | 9.83 | 81 | 337951 | 6036 | 50261056 |
Asthma | 15.28 | 9.83 | 467 | 337565 | 88870 | 50178222 |
Band neutrophil count increased | 15.18 | 9.83 | 15 | 338017 | 336 | 50266756 |
Electrolyte imbalance | 15.18 | 9.83 | 61 | 337971 | 17108 | 50249984 |
Immune reconstitution inflammatory syndrome | 15.16 | 9.83 | 9 | 338023 | 5507 | 50261585 |
Pre-existing condition improved | 15.15 | 9.83 | 15 | 338017 | 7082 | 50260010 |
Cerebral haemorrhage | 15.13 | 9.83 | 112 | 337920 | 26940 | 50240152 |
Macular oedema | 15.12 | 9.83 | 3 | 338029 | 3651 | 50263441 |
Hepatic encephalopathy | 14.97 | 9.83 | 113 | 337919 | 9523 | 50257569 |
Metastases to lung | 14.96 | 9.83 | 32 | 338000 | 10988 | 50256104 |
Acute graft versus host disease | 14.89 | 9.83 | 4 | 338028 | 3954 | 50263138 |
Weight decreased | 14.82 | 9.83 | 1274 | 336758 | 219971 | 50047121 |
Cholecystitis chronic | 14.80 | 9.83 | 113 | 337919 | 9556 | 50257536 |
Schizoaffective disorder | 14.68 | 9.83 | 40 | 337992 | 2166 | 50264926 |
Therapeutic response shortened | 14.65 | 9.83 | 92 | 337940 | 7297 | 50259795 |
Schizophrenia | 14.60 | 9.83 | 92 | 337940 | 7305 | 50259787 |
Ventricular arrhythmia | 14.59 | 9.83 | 52 | 337980 | 3257 | 50263835 |
Transfusion-related acute lung injury | 14.59 | 9.83 | 9 | 338023 | 97 | 50266995 |
Skin ulcer | 14.59 | 9.83 | 158 | 337874 | 35160 | 50231932 |
Thinking abnormal | 14.53 | 9.83 | 26 | 338006 | 9541 | 50257551 |
Angina unstable | 14.51 | 9.83 | 14 | 338018 | 6692 | 50260400 |
Post transplant lymphoproliferative disorder | 14.45 | 9.83 | 5 | 338027 | 4199 | 50262893 |
Hypomagnesaemia | 14.37 | 9.83 | 93 | 337939 | 23063 | 50244029 |
Hypothyroidism | 14.36 | 9.83 | 152 | 337880 | 33973 | 50233119 |
Haemoglobin urine present | 14.35 | 9.83 | 22 | 338010 | 784 | 50266308 |
Speech disorder | 14.30 | 9.83 | 160 | 337872 | 35388 | 50231704 |
Glycosylated haemoglobin increased | 14.23 | 9.83 | 31 | 338001 | 10575 | 50256517 |
Ascites | 14.19 | 9.83 | 162 | 337870 | 35699 | 50231393 |
Coma hepatic | 14.18 | 9.83 | 19 | 338013 | 597 | 50266495 |
Eye pruritus | 14.18 | 9.83 | 40 | 337992 | 12494 | 50254598 |
Culture urine positive | 14.18 | 9.83 | 53 | 337979 | 3398 | 50263694 |
Neutrophil count decreased | 14.17 | 9.83 | 219 | 337813 | 45807 | 50221285 |
Fear of injection | 14.09 | 9.83 | 12 | 338020 | 6091 | 50261001 |
Administration site pruritus | 14.08 | 9.83 | 13 | 338019 | 267 | 50266825 |
Parosmia | 14.05 | 9.83 | 6 | 338026 | 4430 | 50262662 |
Toxicologic test abnormal | 14.01 | 9.83 | 19 | 338013 | 604 | 50266488 |
Vitamin D deficiency | 13.95 | 9.83 | 35 | 337997 | 11367 | 50255725 |
Shoulder arthroplasty | 13.92 | 9.83 | 3 | 338029 | 3445 | 50263647 |
Cells in urine | 13.87 | 9.83 | 11 | 338021 | 182 | 50266910 |
Transplant dysfunction | 13.81 | 9.83 | 7 | 338025 | 4677 | 50262415 |
Nail bed inflammation | 13.80 | 9.83 | 15 | 338017 | 377 | 50266715 |
Oedema | 13.75 | 9.83 | 360 | 337672 | 69821 | 50197271 |
Labelled drug-drug interaction medication error | 13.74 | 9.83 | 31 | 338001 | 10446 | 50256646 |
Flatulence | 13.74 | 9.83 | 128 | 337904 | 29330 | 50237762 |
Cardiotoxicity | 13.72 | 9.83 | 16 | 338016 | 7011 | 50260081 |
Premature delivery | 13.71 | 9.83 | 97 | 337935 | 23566 | 50243526 |
Derailment | 13.65 | 9.83 | 7 | 338025 | 51 | 50267041 |
Treatment noncompliance | 13.64 | 9.83 | 132 | 337900 | 30018 | 50237074 |
Device breakage | 13.57 | 9.83 | 27 | 338005 | 9520 | 50257572 |
Galactorrhoea | 13.56 | 9.83 | 4 | 338028 | 3719 | 50263373 |
Lip swelling | 13.56 | 9.83 | 103 | 337929 | 24633 | 50242459 |
Loss of personal independence in daily activities | 13.55 | 9.83 | 360 | 337672 | 69690 | 50197402 |
Product physical issue | 13.50 | 9.83 | 6 | 338026 | 4326 | 50262766 |
Pneumonia viral | 13.49 | 9.83 | 85 | 337947 | 6749 | 50260343 |
Unresponsive to stimuli | 13.46 | 9.83 | 283 | 337749 | 30326 | 50236766 |
Blood lactic acid increased | 13.31 | 9.83 | 73 | 337959 | 5512 | 50261580 |
Administration site extravasation | 13.29 | 9.83 | 20 | 338012 | 701 | 50266391 |
Ejection fraction decreased | 13.29 | 9.83 | 71 | 337961 | 18449 | 50248643 |
Thrombotic microangiopathy | 13.25 | 9.83 | 24 | 338008 | 8767 | 50258325 |
Invasive ductal breast carcinoma | 13.24 | 9.83 | 12 | 338020 | 5909 | 50261183 |
Balance disorder | 13.13 | 9.83 | 587 | 337445 | 70003 | 50197089 |
Blood bilirubin increased | 13.07 | 9.83 | 293 | 337739 | 31745 | 50235347 |
Gastrointestinal pain | 13.05 | 9.83 | 21 | 338011 | 8035 | 50259057 |
Asphyxia | 12.98 | 9.83 | 71 | 337961 | 5356 | 50261736 |
Sputum culture positive | 12.98 | 9.83 | 29 | 338003 | 1385 | 50265707 |
Caesarean section | 12.94 | 9.83 | 57 | 337975 | 15582 | 50251510 |
Amenorrhoea | 12.93 | 9.83 | 23 | 338009 | 8461 | 50258631 |
Abnormal dreams | 12.92 | 9.83 | 27 | 338005 | 9350 | 50257742 |
Cardiac failure acute | 12.91 | 9.83 | 22 | 338010 | 8228 | 50258864 |
Vitamin K deficiency | 12.87 | 9.83 | 15 | 338017 | 408 | 50266684 |
Infusion site rash | 12.86 | 9.83 | 28 | 338004 | 1314 | 50265778 |
Eating disorder | 12.85 | 9.83 | 56 | 337976 | 15353 | 50251739 |
Ductus arteriosus stenosis foetal | 12.84 | 9.83 | 10 | 338022 | 161 | 50266931 |
Eosinophil percentage increased | 12.82 | 9.83 | 23 | 338009 | 935 | 50266157 |
Dysphagia | 12.82 | 9.83 | 407 | 337625 | 77111 | 50189981 |
Swelling face | 12.77 | 9.83 | 261 | 337771 | 52334 | 50214758 |
Tardive dyskinesia | 12.74 | 9.83 | 18 | 338014 | 7261 | 50259831 |
Impaired quality of life | 12.70 | 9.83 | 13 | 338019 | 6043 | 50261049 |
Mood swings | 12.69 | 9.83 | 59 | 337973 | 15895 | 50251197 |
Blood uric acid decreased | 12.69 | 9.83 | 19 | 338013 | 663 | 50266429 |
Metastases to lymph nodes | 12.66 | 9.83 | 17 | 338015 | 7007 | 50260085 |
Alpha 1 microglobulin increased | 12.60 | 9.83 | 7 | 338025 | 61 | 50267031 |
Epstein-Barr virus infection | 12.55 | 9.83 | 17 | 338015 | 6980 | 50260112 |
Death | 12.51 | 9.83 | 2410 | 335622 | 322969 | 49944123 |
Blindness | 12.51 | 9.83 | 66 | 337966 | 17203 | 50249889 |
Coagulation factor X level decreased | 12.50 | 9.83 | 7 | 338025 | 62 | 50267030 |
Infective pulmonary exacerbation of cystic fibrosis | 12.46 | 9.83 | 21 | 338011 | 7888 | 50259204 |
Encephalopathy | 12.43 | 9.83 | 304 | 337728 | 33407 | 50233685 |
Intestinal haemorrhage | 12.37 | 9.83 | 3 | 338029 | 3177 | 50263915 |
Antidepressant drug level above therapeutic | 12.35 | 9.83 | 14 | 338018 | 369 | 50266723 |
Sleep apnoea syndrome | 12.33 | 9.83 | 101 | 337931 | 23767 | 50243325 |
Administration site bruise | 12.21 | 9.83 | 12 | 338020 | 267 | 50266825 |
Product preparation error | 12.21 | 9.83 | 7 | 338025 | 4365 | 50262727 |
Injury | 12.19 | 9.83 | 420 | 337612 | 48505 | 50218587 |
Atypical femur fracture | 12.19 | 9.83 | 9 | 338023 | 4907 | 50262185 |
Hemiplegia | 12.19 | 9.83 | 19 | 338013 | 7362 | 50259730 |
Traumatic liver injury | 12.18 | 9.83 | 12 | 338020 | 268 | 50266824 |
Pregnancy with contraceptive device | 12.17 | 9.83 | 6 | 338026 | 4073 | 50263019 |
Therapy non-responder | 12.15 | 9.83 | 254 | 337778 | 50768 | 50216324 |
Drug withdrawal syndrome | 12.12 | 9.83 | 108 | 337924 | 24973 | 50242119 |
Uterine perforation | 12.11 | 9.83 | 15 | 338017 | 6400 | 50260692 |
Anoxia | 12.07 | 9.83 | 11 | 338021 | 222 | 50266870 |
Rheumatoid nodule | 12.06 | 9.83 | 44 | 337988 | 12691 | 50254401 |
Low density lipoprotein increased | 11.97 | 9.83 | 12 | 338020 | 5634 | 50261458 |
Coagulation factor VII level decreased | 11.88 | 9.83 | 7 | 338025 | 69 | 50267023 |
Urine analysis abnormal | 11.85 | 9.83 | 59 | 337973 | 4291 | 50262801 |
Hallucination | 11.79 | 9.83 | 230 | 337802 | 46427 | 50220665 |
Renal disorder | 11.78 | 9.83 | 122 | 337910 | 27383 | 50239709 |
Intermenstrual bleeding | 11.78 | 9.83 | 17 | 338015 | 6797 | 50260295 |
Vertigo | 11.77 | 9.83 | 260 | 337772 | 51572 | 50215520 |
Pleural effusion | 11.77 | 9.83 | 435 | 337597 | 81019 | 50186073 |
Low turnover osteopathy | 11.73 | 9.83 | 6 | 338026 | 3988 | 50263104 |
Pulmonary mass | 11.67 | 9.83 | 75 | 337957 | 18630 | 50248462 |
Cardiogenic shock | 11.65 | 9.83 | 59 | 337973 | 15540 | 50251552 |
Status epilepticus | 11.62 | 9.83 | 48 | 337984 | 13358 | 50253734 |
Myelocyte count increased | 11.55 | 9.83 | 13 | 338019 | 340 | 50266752 |
Complication of device insertion | 11.53 | 9.83 | 14 | 338018 | 6027 | 50261065 |
Asthenia | 11.53 | 9.83 | 1914 | 336118 | 317128 | 49949964 |
Urine ketone body present | 11.46 | 9.83 | 38 | 337994 | 2295 | 50264797 |
Base excess | 11.38 | 9.83 | 7 | 338025 | 75 | 50267017 |
Nightmare | 11.36 | 9.83 | 62 | 337970 | 16024 | 50251068 |
Metastases to central nervous system | 11.35 | 9.83 | 38 | 337994 | 11244 | 50255848 |
Skin toxicity | 11.31 | 9.83 | 6 | 338026 | 3907 | 50263185 |
Eczema | 11.31 | 9.83 | 97 | 337935 | 22605 | 50244487 |
Priapism | 11.23 | 9.83 | 7 | 338025 | 77 | 50267015 |
Therapy change | 11.20 | 9.83 | 11 | 338021 | 5214 | 50261878 |
Continuous haemodiafiltration | 11.18 | 9.83 | 22 | 338010 | 960 | 50266132 |
Skin burning sensation | 11.16 | 9.83 | 33 | 337999 | 10152 | 50256940 |
Diaphragmatic rupture | 11.08 | 9.83 | 11 | 338021 | 248 | 50266844 |
Hepatitis acute | 11.07 | 9.83 | 91 | 337941 | 7870 | 50259222 |
Delusion | 11.04 | 9.83 | 35 | 337997 | 10534 | 50256558 |
Hypoaesthesia | 11.03 | 9.83 | 717 | 337315 | 126540 | 50140552 |
Monocyte count increased | 11.00 | 9.83 | 69 | 337963 | 5470 | 50261622 |
Diffuse large B-cell lymphoma | 10.94 | 9.83 | 13 | 338019 | 5649 | 50261443 |
Type 2 diabetes mellitus | 10.93 | 9.83 | 304 | 337728 | 34071 | 50233021 |
Gastroenteritis | 10.93 | 9.83 | 101 | 337931 | 23180 | 50243912 |
Erysipelas | 10.92 | 9.83 | 17 | 338015 | 6591 | 50260501 |
Flushing | 10.92 | 9.83 | 550 | 337482 | 66465 | 50200627 |
Endophthalmitis | 10.87 | 9.83 | 3 | 338029 | 2913 | 50264179 |
Medication overuse headache | 10.84 | 9.83 | 17 | 338015 | 618 | 50266474 |
Uterine cancer | 10.83 | 9.83 | 6 | 338026 | 3814 | 50263278 |
Device leakage | 10.83 | 9.83 | 14 | 338018 | 5864 | 50261228 |
Administration site reaction | 10.80 | 9.83 | 10 | 338022 | 206 | 50266886 |
Gait inability | 10.79 | 9.83 | 178 | 337854 | 36849 | 50230243 |
Application site pain | 10.72 | 9.83 | 6 | 338026 | 3792 | 50263300 |
Acute myeloid leukaemia | 10.70 | 9.83 | 58 | 337974 | 15016 | 50252076 |
Cardiovascular disorder | 10.66 | 9.83 | 35 | 337997 | 10419 | 50256673 |
Device deployment issue | 10.65 | 9.83 | 5 | 338027 | 3491 | 50263601 |
Band neutrophil percentage increased | 10.61 | 9.83 | 10 | 338022 | 211 | 50266881 |
Chronic graft versus host disease | 10.59 | 9.83 | 3 | 338029 | 2864 | 50264228 |
Dyskinesia | 10.58 | 9.83 | 127 | 337905 | 27734 | 50239358 |
Intervertebral disc degeneration | 10.58 | 9.83 | 50 | 337982 | 13411 | 50253681 |
Mental impairment | 10.52 | 9.83 | 43 | 337989 | 12001 | 50255091 |
Autonomic dysreflexia | 10.51 | 9.83 | 12 | 338020 | 319 | 50266773 |
Skin infection | 10.51 | 9.83 | 127 | 337905 | 12164 | 50254928 |
Accident at home | 10.49 | 9.83 | 9 | 338023 | 167 | 50266925 |
Vaginal haemorrhage | 10.48 | 9.83 | 109 | 337923 | 24442 | 50242650 |
Skin lesion | 10.47 | 9.83 | 121 | 337911 | 26606 | 50240486 |
Drug abuser | 10.45 | 9.83 | 42 | 337990 | 2786 | 50264306 |
Ischaemic stroke | 10.44 | 9.83 | 63 | 337969 | 15885 | 50251207 |
Ocular hyperaemia | 10.42 | 9.83 | 86 | 337946 | 20206 | 50246886 |
Drug eruption | 10.40 | 9.83 | 104 | 337928 | 23502 | 50243590 |
Metastases to peritoneum | 10.40 | 9.83 | 3 | 338029 | 2830 | 50264262 |
Vital capacity decreased | 10.39 | 9.83 | 21 | 338011 | 935 | 50266157 |
Hunger | 10.32 | 9.83 | 8 | 338024 | 4255 | 50262837 |
Congestive cardiomyopathy | 10.31 | 9.83 | 13 | 338019 | 5505 | 50261587 |
Urinary casts | 10.30 | 9.83 | 17 | 338015 | 646 | 50266446 |
Dysphoria | 10.29 | 9.83 | 10 | 338022 | 4764 | 50262328 |
Dyslipidaemia | 10.29 | 9.83 | 15 | 338017 | 5973 | 50261119 |
Deafness | 10.26 | 9.83 | 62 | 337970 | 15629 | 50251463 |
Abdominal pain upper | 10.25 | 9.83 | 1215 | 336817 | 158094 | 50108998 |
Eructation | 10.24 | 9.83 | 20 | 338012 | 7101 | 50259991 |
Eye haemorrhage | 10.21 | 9.83 | 21 | 338011 | 7314 | 50259778 |
Mean cell haemoglobin concentration decreased | 10.20 | 9.83 | 42 | 337990 | 2817 | 50264275 |
Large intestine polyp | 10.19 | 9.83 | 21 | 338011 | 7311 | 50259781 |
Frequent bowel movements | 10.19 | 9.83 | 53 | 337979 | 13865 | 50253227 |
Obstructive airways disorder | 10.16 | 9.83 | 62 | 337970 | 15590 | 50251502 |
Left ventricular dysfunction | 10.15 | 9.83 | 36 | 337996 | 10470 | 50256622 |
Pharyngeal paraesthesia | 10.14 | 9.83 | 27 | 338005 | 1442 | 50265650 |
Corneal reflex decreased | 10.11 | 9.83 | 8 | 338024 | 132 | 50266960 |
Head injury | 10.10 | 9.83 | 107 | 337925 | 23913 | 50243179 |
Aplasia pure red cell | 10.09 | 9.83 | 8 | 338024 | 4207 | 50262885 |
Drug use disorder | 10.08 | 9.83 | 44 | 337988 | 3028 | 50264064 |
Drug tolerance | 10.08 | 9.83 | 11 | 338021 | 4965 | 50262127 |
Device related thrombosis | 10.03 | 9.83 | 25 | 338007 | 1282 | 50265810 |
Accidental death | 10.03 | 9.83 | 30 | 338002 | 1714 | 50265378 |
Urine oxalate increased | 10.02 | 9.83 | 10 | 338022 | 227 | 50266865 |
Infusion site reaction | 10.01 | 9.83 | 35 | 337997 | 2171 | 50264921 |
Congestive hepatopathy | 10.00 | 9.83 | 38 | 337994 | 2456 | 50264636 |
Plasma cell myeloma | 9.99 | 9.83 | 148 | 337884 | 31174 | 50235918 |
Femoral neck fracture | 9.96 | 9.83 | 22 | 338010 | 7468 | 50259624 |
Brain stem glioma | 9.96 | 9.83 | 8 | 338024 | 135 | 50266957 |
Impaired work ability | 9.95 | 9.83 | 52 | 337980 | 13588 | 50253504 |
Peripheral sensory neuropathy | 9.93 | 9.83 | 18 | 338014 | 6573 | 50260519 |
Hip fracture | 9.93 | 9.83 | 118 | 337914 | 25813 | 50241279 |
Deep vein thrombosis postoperative | 9.92 | 9.83 | 29 | 338003 | 1636 | 50265456 |
Irritability | 9.89 | 9.83 | 132 | 337900 | 28294 | 50238798 |
Excessive skin | 9.86 | 9.83 | 8 | 338024 | 137 | 50266955 |
Adverse drug reaction | 9.85 | 9.83 | 287 | 337745 | 54935 | 50212157 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1284.93 | 9.87 | 1833 | 136797 | 88413 | 29347484 |
Toxicity to various agents | 1115.92 | 9.87 | 2488 | 136142 | 171173 | 29264724 |
Infusion related reaction | 437.40 | 9.87 | 758 | 137872 | 43128 | 29392769 |
Overdose | 374.60 | 9.87 | 1016 | 137614 | 78803 | 29357094 |
Blood pressure fluctuation | 345.70 | 9.87 | 446 | 138184 | 19448 | 29416449 |
Exposure to toxic agent | 291.82 | 9.87 | 170 | 138460 | 2405 | 29433492 |
Acute hepatic failure | 269.78 | 9.87 | 306 | 138324 | 11646 | 29424251 |
Intentional product misuse | 259.62 | 9.87 | 530 | 138100 | 34131 | 29401766 |
Drug ineffective | 197.93 | 9.87 | 954 | 137676 | 362216 | 29073681 |
Intentional overdose | 182.03 | 9.87 | 492 | 138138 | 38036 | 29397861 |
Heart rate decreased | 150.06 | 9.87 | 349 | 138281 | 24563 | 29411334 |
Blood pressure increased | 119.19 | 9.87 | 670 | 137960 | 73133 | 29362764 |
Metabolic acidosis | 119.04 | 9.87 | 418 | 138212 | 37244 | 29398653 |
Product dose omission issue | 95.74 | 9.87 | 192 | 138438 | 96191 | 29339706 |
Oxygen saturation decreased | 92.74 | 9.87 | 437 | 138193 | 44500 | 29391397 |
Cardio-respiratory arrest | 92.26 | 9.87 | 475 | 138155 | 50126 | 29385771 |
Hepatic cytolysis | 92.09 | 9.87 | 151 | 138479 | 8196 | 29427701 |
Respiratory arrest | 89.77 | 9.87 | 296 | 138334 | 25537 | 29410360 |
Hepatotoxicity | 86.18 | 9.87 | 230 | 138400 | 17637 | 29418260 |
Anion gap | 84.48 | 9.87 | 49 | 138581 | 687 | 29435210 |
Coagulopathy | 82.85 | 9.87 | 227 | 138403 | 17680 | 29418217 |
Diarrhoea | 77.38 | 9.87 | 1097 | 137533 | 331601 | 29104296 |
Myocardial infarction | 76.48 | 9.87 | 263 | 138367 | 110033 | 29325864 |
Accidental overdose | 72.60 | 9.87 | 214 | 138416 | 17379 | 29418518 |
Substance abuse | 71.15 | 9.87 | 120 | 138510 | 6667 | 29429230 |
Cardiac failure congestive | 66.64 | 9.87 | 164 | 138466 | 76417 | 29359480 |
Hepatic necrosis | 63.99 | 9.87 | 81 | 138549 | 3461 | 29432436 |
Intentional product use issue | 62.81 | 9.87 | 377 | 138253 | 42121 | 29393776 |
Drug resistance | 61.35 | 9.87 | 13 | 138617 | 21527 | 29414370 |
Sinusitis | 60.20 | 9.87 | 319 | 138311 | 34031 | 29401866 |
Heart rate irregular | 59.40 | 9.87 | 165 | 138465 | 12952 | 29422945 |
Respiratory depression | 59.17 | 9.87 | 168 | 138462 | 13355 | 29422542 |
Neonatal hypoxia | 59.11 | 9.87 | 31 | 138599 | 352 | 29435545 |
Suspected suicide | 57.44 | 9.87 | 82 | 138548 | 3938 | 29431959 |
Hypotension | 56.53 | 9.87 | 1249 | 137381 | 193105 | 29242792 |
Blood pressure diastolic abnormal | 55.33 | 9.87 | 64 | 138566 | 2487 | 29433410 |
Alanine aminotransferase increased | 54.97 | 9.87 | 541 | 138089 | 70403 | 29365494 |
Chills | 54.90 | 9.87 | 543 | 138087 | 70757 | 29365140 |
Blood pressure systolic increased | 54.09 | 9.87 | 188 | 138442 | 16657 | 29419240 |
Liver injury | 53.93 | 9.87 | 156 | 138474 | 12534 | 29423363 |
Treatment failure | 52.87 | 9.87 | 57 | 138573 | 36882 | 29399015 |
Medication error | 49.52 | 9.87 | 214 | 138416 | 20997 | 29414900 |
Poisoning | 45.54 | 9.87 | 126 | 138504 | 9867 | 29426030 |
Aspartate aminotransferase increased | 44.59 | 9.87 | 452 | 138178 | 59273 | 29376624 |
Heart rate increased | 43.39 | 9.87 | 322 | 138308 | 38616 | 29397281 |
Infusion site extravasation | 42.08 | 9.87 | 62 | 138568 | 3065 | 29432832 |
Analgesic drug level increased | 41.83 | 9.87 | 29 | 138601 | 563 | 29435334 |
Blood pressure diastolic increased | 39.74 | 9.87 | 66 | 138564 | 3620 | 29432277 |
Cardiac failure | 39.62 | 9.87 | 214 | 138416 | 79073 | 29356824 |
Exposure via ingestion | 37.81 | 9.87 | 47 | 138583 | 1971 | 29433926 |
Toxic epidermal necrolysis | 37.76 | 9.87 | 177 | 138453 | 17976 | 29417921 |
Drug abuse | 37.57 | 9.87 | 554 | 138076 | 79329 | 29356568 |
Body temperature decreased | 36.86 | 9.87 | 122 | 138508 | 10542 | 29425355 |
Blood pressure systolic abnormal | 36.81 | 9.87 | 48 | 138582 | 2113 | 29433784 |
Neuropathy peripheral | 36.44 | 9.87 | 190 | 138440 | 70837 | 29365060 |
Pyroglutamic acidosis | 35.86 | 9.87 | 20 | 138610 | 259 | 29435638 |
Blood pressure diastolic decreased | 35.49 | 9.87 | 92 | 138538 | 6930 | 29428967 |
Infusion site pain | 35.12 | 9.87 | 55 | 138575 | 2870 | 29433027 |
Cardiac arrest | 35.08 | 9.87 | 580 | 138050 | 85011 | 29350886 |
Depressed level of consciousness | 34.84 | 9.87 | 294 | 138336 | 36648 | 29399249 |
Therapeutic response shortened | 34.35 | 9.87 | 72 | 138558 | 4719 | 29431178 |
Therapeutic product effect incomplete | 34.30 | 9.87 | 84 | 138546 | 39221 | 29396676 |
Cytokine release syndrome | 34.26 | 9.87 | 137 | 138493 | 12982 | 29422915 |
Psoriasis | 33.88 | 9.87 | 62 | 138568 | 32165 | 29403732 |
Renal cortical necrosis | 32.61 | 9.87 | 16 | 138614 | 156 | 29435741 |
Stevens-Johnson syndrome | 32.25 | 9.87 | 158 | 138472 | 16339 | 29419558 |
Contraindicated product administered | 31.11 | 9.87 | 24 | 138606 | 18242 | 29417655 |
Neutrophil percentage increased | 31.02 | 9.87 | 40 | 138590 | 1741 | 29434156 |
Appendicolith | 30.63 | 9.87 | 57 | 138573 | 3423 | 29432474 |
Rheumatoid arthritis | 30.38 | 9.87 | 256 | 138374 | 31896 | 29404001 |
Suicide attempt | 30.35 | 9.87 | 268 | 138362 | 33842 | 29402055 |
Coronary artery disease | 30.16 | 9.87 | 106 | 138524 | 44084 | 29391813 |
Product use in unapproved indication | 29.75 | 9.87 | 262 | 138368 | 86613 | 29349284 |
Infusion site swelling | 29.49 | 9.87 | 40 | 138590 | 1830 | 29434067 |
International normalised ratio increased | 29.00 | 9.87 | 327 | 138303 | 44045 | 29391852 |
Injection site pain | 28.58 | 9.87 | 69 | 138561 | 32377 | 29403520 |
Pyrexia | 28.45 | 9.87 | 1633 | 136997 | 285989 | 29149908 |
Sopor | 28.40 | 9.87 | 8 | 138622 | 10926 | 29424971 |
Anaemia | 28.40 | 9.87 | 721 | 137909 | 200230 | 29235667 |
Blood pH decreased | 28.28 | 9.87 | 42 | 138588 | 2091 | 29433806 |
Hepatic failure | 28.25 | 9.87 | 248 | 138382 | 31264 | 29404633 |
Tachycardia | 27.96 | 9.87 | 486 | 138144 | 71924 | 29363973 |
Aplastic anaemia | 27.84 | 9.87 | 88 | 138542 | 7422 | 29428475 |
Product prescribing error | 27.70 | 9.87 | 26 | 138604 | 17950 | 29417947 |
Unresponsive to stimuli | 27.54 | 9.87 | 207 | 138423 | 24919 | 29410978 |
Body temperature increased | 27.18 | 9.87 | 137 | 138493 | 14328 | 29421569 |
Myocardial fibrosis | 26.95 | 9.87 | 29 | 138601 | 1039 | 29434858 |
Wrong technique in product usage process | 26.77 | 9.87 | 68 | 138562 | 31360 | 29404537 |
Dizziness | 26.68 | 9.87 | 681 | 137949 | 189003 | 29246894 |
Memory impairment | 26.59 | 9.87 | 85 | 138545 | 36385 | 29399512 |
Methaemoglobinaemia | 26.38 | 9.87 | 46 | 138584 | 2625 | 29433272 |
Hospitalisation | 25.90 | 9.87 | 119 | 138511 | 45869 | 29390028 |
Disease progression | 25.49 | 9.87 | 253 | 138377 | 81663 | 29354234 |
Asthenia | 25.38 | 9.87 | 792 | 137838 | 214458 | 29221439 |
Abdominal pain | 25.19 | 9.87 | 821 | 137809 | 134536 | 29301361 |
Pulmonary oedema | 24.86 | 9.87 | 308 | 138322 | 42427 | 29393470 |
Depression | 24.85 | 9.87 | 267 | 138363 | 84880 | 29351017 |
Body temperature fluctuation | 24.38 | 9.87 | 32 | 138598 | 1418 | 29434479 |
Lymphocyte percentage decreased | 24.32 | 9.87 | 38 | 138592 | 1979 | 29433918 |
Urticaria | 24.11 | 9.87 | 375 | 138255 | 54285 | 29381612 |
Urine sodium decreased | 23.81 | 9.87 | 13 | 138617 | 161 | 29435736 |
Fatigue | 23.71 | 9.87 | 1229 | 137401 | 315592 | 29120305 |
Bone marrow failure | 23.68 | 9.87 | 59 | 138571 | 27390 | 29408507 |
Respiratory rate increased | 22.78 | 9.87 | 91 | 138539 | 8617 | 29427280 |
Malignant neoplasm progression | 22.61 | 9.87 | 229 | 138401 | 73630 | 29362267 |
Glycosylated haemoglobin increased | 22.52 | 9.87 | 8 | 138622 | 9418 | 29426479 |
Prothrombin time prolonged | 22.08 | 9.87 | 91 | 138539 | 8741 | 29427156 |
Poor venous access | 22.08 | 9.87 | 47 | 138583 | 3114 | 29432783 |
Interstitial lung disease | 22.06 | 9.87 | 169 | 138461 | 57549 | 29378348 |
Febrile neutropenia | 21.98 | 9.87 | 685 | 137945 | 111555 | 29324342 |
Acute lung injury | 21.76 | 9.87 | 29 | 138601 | 1304 | 29434593 |
Coma | 21.53 | 9.87 | 281 | 138349 | 39169 | 29396728 |
Progressive multifocal leukoencephalopathy | 21.52 | 9.87 | 7 | 138623 | 8712 | 29427185 |
Diabetes mellitus | 21.30 | 9.87 | 105 | 138525 | 39726 | 29396171 |
Ear infection | 20.68 | 9.87 | 84 | 138546 | 8016 | 29427881 |
Ductus arteriosus premature closure | 20.50 | 9.87 | 13 | 138617 | 216 | 29435681 |
Infusion site pruritus | 20.40 | 9.87 | 18 | 138612 | 503 | 29435394 |
Inappropriate schedule of product administration | 20.33 | 9.87 | 307 | 138323 | 44165 | 29391732 |
Cerebral artery thrombosis | 20.24 | 9.87 | 21 | 138609 | 721 | 29435176 |
Visual acuity reduced | 20.14 | 9.87 | 24 | 138606 | 14852 | 29421045 |
Granulomatosis with polyangiitis | 20.10 | 9.87 | 23 | 138607 | 883 | 29435014 |
Feeling abnormal | 20.07 | 9.87 | 161 | 138469 | 54284 | 29381613 |
Drug interaction | 19.60 | 9.87 | 742 | 137888 | 196643 | 29239254 |
Brain scan abnormal | 19.58 | 9.87 | 22 | 138608 | 828 | 29435069 |
Renal impairment | 19.55 | 9.87 | 266 | 138364 | 81067 | 29354830 |
Balance disorder | 19.54 | 9.87 | 95 | 138535 | 36075 | 29399822 |
Full blood count abnormal | 19.51 | 9.87 | 25 | 138605 | 14988 | 29420909 |
Cerebrovascular accident | 19.41 | 9.87 | 249 | 138381 | 76662 | 29359235 |
Haemolysis | 19.26 | 9.87 | 74 | 138556 | 6882 | 29429015 |
Cerebral haemorrhage | 19.10 | 9.87 | 79 | 138551 | 31347 | 29404550 |
Brain death | 18.63 | 9.87 | 37 | 138593 | 2333 | 29433564 |
Dyspnoea | 18.49 | 9.87 | 1301 | 137329 | 325431 | 29110466 |
Throat tightness | 18.47 | 9.87 | 74 | 138556 | 7017 | 29428880 |
Transaminases increased | 18.11 | 9.87 | 174 | 138456 | 22488 | 29413409 |
Oxygen saturation abnormal | 18.05 | 9.87 | 25 | 138605 | 1167 | 29434730 |
Osteonecrosis of jaw | 18.04 | 9.87 | 31 | 138599 | 16479 | 29419418 |
Immune reconstitution inflammatory syndrome | 18.00 | 9.87 | 7 | 138623 | 7795 | 29428102 |
Chronic gastrointestinal bleeding | 17.92 | 9.87 | 13 | 138617 | 272 | 29435625 |
Cerebral infarction | 17.64 | 9.87 | 58 | 138572 | 24617 | 29411280 |
Anion gap abnormal | 17.44 | 9.87 | 10 | 138620 | 137 | 29435760 |
Graft versus host disease | 17.24 | 9.87 | 12 | 138618 | 9616 | 29426281 |
Haematotoxicity | 17.22 | 9.87 | 5 | 138625 | 6694 | 29429203 |
Infusion site rash | 17.17 | 9.87 | 14 | 138616 | 350 | 29435547 |
Drug ineffective for unapproved indication | 17.13 | 9.87 | 25 | 138605 | 14189 | 29421708 |
Blood triglycerides increased | 17.06 | 9.87 | 21 | 138609 | 12813 | 29423084 |
Pemphigus | 16.95 | 9.87 | 24 | 138606 | 1144 | 29434753 |
Acidosis | 16.90 | 9.87 | 90 | 138540 | 9615 | 29426282 |
Pulmonary congestion | 16.90 | 9.87 | 108 | 138522 | 12328 | 29423569 |
Flushing | 16.88 | 9.87 | 209 | 138421 | 28783 | 29407114 |
Nasopharyngitis | 16.82 | 9.87 | 382 | 138248 | 59283 | 29376614 |
Renal papillary necrosis | 16.60 | 9.87 | 10 | 138620 | 151 | 29435746 |
Psoriatic arthropathy | 16.59 | 9.87 | 27 | 138603 | 14664 | 29421233 |
Fluid retention | 16.42 | 9.87 | 56 | 138574 | 23504 | 29412393 |
Decreased appetite | 16.33 | 9.87 | 538 | 138092 | 144804 | 29291093 |
Oedema peripheral | 15.84 | 9.87 | 367 | 138263 | 103190 | 29332707 |
Inadequate analgesia | 15.77 | 9.87 | 37 | 138593 | 2617 | 29433280 |
Urethral valves | 15.76 | 9.87 | 12 | 138618 | 271 | 29435626 |
Lung neoplasm malignant | 15.65 | 9.87 | 27 | 138603 | 14330 | 29421567 |
Dependent personality disorder | 15.40 | 9.87 | 8 | 138622 | 89 | 29435808 |
Accidental death | 15.38 | 9.87 | 32 | 138598 | 2086 | 29433811 |
Myopathy | 15.35 | 9.87 | 16 | 138614 | 10517 | 29425380 |
Angina pectoris | 15.13 | 9.87 | 73 | 138557 | 27777 | 29408120 |
Administration site pain | 15.12 | 9.87 | 10 | 138620 | 179 | 29435718 |
Therapeutic response decreased | 15.09 | 9.87 | 62 | 138568 | 24649 | 29411248 |
Appendicitis | 15.01 | 9.87 | 81 | 138549 | 8698 | 29427199 |
Foetal exposure during pregnancy | 14.99 | 9.87 | 95 | 138535 | 33772 | 29402125 |
Visual impairment | 14.93 | 9.87 | 80 | 138550 | 29628 | 29406269 |
Mucosal inflammation | 14.83 | 9.87 | 87 | 138543 | 31508 | 29404389 |
Mental status changes | 14.78 | 9.87 | 238 | 138392 | 34689 | 29401208 |
Venoocclusive liver disease | 14.70 | 9.87 | 7 | 138623 | 6910 | 29428987 |
Pallor | 14.68 | 9.87 | 157 | 138473 | 20867 | 29415030 |
Leukopenia | 14.57 | 9.87 | 177 | 138453 | 55026 | 29380871 |
Acute myocardial infarction | 14.48 | 9.87 | 151 | 138479 | 48287 | 29387610 |
Asthma | 14.45 | 9.87 | 96 | 138534 | 33753 | 29402144 |
Infusion site erythema | 14.33 | 9.87 | 27 | 138603 | 1637 | 29434260 |
Bilirubin urine present | 14.32 | 9.87 | 9 | 138621 | 147 | 29435750 |
Post transplant lymphoproliferative disorder | 14.30 | 9.87 | 4 | 138626 | 5489 | 29430408 |
Cardiac disorder | 14.29 | 9.87 | 109 | 138521 | 37154 | 29398743 |
Failure to suspend medication | 14.27 | 9.87 | 13 | 138617 | 379 | 29435518 |
Environmental exposure | 14.16 | 9.87 | 11 | 138619 | 256 | 29435641 |
Labelled drug-drug interaction medication error | 14.06 | 9.87 | 22 | 138608 | 12137 | 29423760 |
No adverse event | 13.99 | 9.87 | 39 | 138591 | 17439 | 29418458 |
Administration site erythema | 13.95 | 9.87 | 7 | 138623 | 72 | 29435825 |
Therapeutic product effect decreased | 13.88 | 9.87 | 81 | 138549 | 29370 | 29406527 |
Product quality issue | 13.84 | 9.87 | 34 | 138596 | 15861 | 29420036 |
Maternal exposure before pregnancy | 13.75 | 9.87 | 14 | 138616 | 470 | 29435427 |
Throat irritation | 13.65 | 9.87 | 79 | 138551 | 8706 | 29427191 |
Loss of personal independence in daily activities | 13.63 | 9.87 | 67 | 138563 | 25373 | 29410524 |
Monocyte percentage increased | 13.60 | 9.87 | 19 | 138611 | 894 | 29435003 |
Brain oedema | 13.57 | 9.87 | 101 | 138529 | 12119 | 29423778 |
Pathogen resistance | 13.40 | 9.87 | 11 | 138619 | 8105 | 29427792 |
Anti-erythrocyte antibody positive | 13.36 | 9.87 | 6 | 138624 | 47 | 29435850 |
Myelosuppression | 13.32 | 9.87 | 23 | 138607 | 12204 | 29423693 |
Cardiac failure chronic | 13.06 | 9.87 | 7 | 138623 | 6460 | 29429437 |
Infusion site nodule | 13.01 | 9.87 | 7 | 138623 | 84 | 29435813 |
Injection site swelling | 12.96 | 9.87 | 15 | 138615 | 9402 | 29426495 |
Tendonitis | 12.88 | 9.87 | 11 | 138619 | 7950 | 29427947 |
Prescribed overdose | 12.87 | 9.87 | 13 | 138617 | 8670 | 29427227 |
Anion gap increased | 12.82 | 9.87 | 25 | 138605 | 1555 | 29434342 |
Hyperlipidaemia | 12.55 | 9.87 | 25 | 138605 | 12565 | 29423332 |
Cytomegalovirus infection | 12.52 | 9.87 | 61 | 138569 | 23154 | 29412743 |
Prostatic specific antigen increased | 12.48 | 9.87 | 25 | 138605 | 12539 | 29423358 |
COVID-19 immunisation | 12.46 | 9.87 | 8 | 138622 | 136 | 29435761 |
Infusion site bruising | 12.43 | 9.87 | 12 | 138618 | 377 | 29435520 |
Acid-base balance disorder mixed | 12.36 | 9.87 | 6 | 138624 | 57 | 29435840 |
Drug level below therapeutic | 12.29 | 9.87 | 46 | 138584 | 4225 | 29431672 |
Infusion site haemorrhage | 12.28 | 9.87 | 16 | 138614 | 704 | 29435193 |
Endocardial fibrosis | 12.25 | 9.87 | 5 | 138625 | 30 | 29435867 |
Pyroglutamate increased | 12.10 | 9.87 | 10 | 138620 | 255 | 29435642 |
Peripheral swelling | 12.09 | 9.87 | 218 | 138412 | 63521 | 29372376 |
Bladder cancer | 12.02 | 9.87 | 18 | 138612 | 10109 | 29425788 |
Injection site haemorrhage | 11.93 | 9.87 | 13 | 138617 | 8373 | 29427524 |
C-reactive protein abnormal | 11.90 | 9.87 | 8 | 138622 | 6528 | 29429369 |
Parkinsonism | 11.85 | 9.87 | 10 | 138620 | 7268 | 29428629 |
Urine abnormality | 11.61 | 9.87 | 25 | 138605 | 1669 | 29434228 |
Apnoea | 11.61 | 9.87 | 58 | 138572 | 6044 | 29429853 |
Hepatitis fulminant | 11.59 | 9.87 | 40 | 138590 | 3531 | 29432366 |
Sleep disorder | 11.53 | 9.87 | 67 | 138563 | 24319 | 29411578 |
Bacterial test | 11.51 | 9.87 | 8 | 138622 | 156 | 29435741 |
Gait disturbance | 11.47 | 9.87 | 259 | 138371 | 73090 | 29362807 |
Crystal urine present | 11.45 | 9.87 | 12 | 138618 | 417 | 29435480 |
Adrenergic syndrome | 11.37 | 9.87 | 6 | 138624 | 69 | 29435828 |
Liver transplant | 11.35 | 9.87 | 30 | 138600 | 2286 | 29433611 |
Diabetic ketoacidosis | 11.34 | 9.87 | 38 | 138592 | 16035 | 29419862 |
Vital functions abnormal | 11.33 | 9.87 | 8 | 138622 | 160 | 29435737 |
Myalgia | 11.12 | 9.87 | 263 | 138367 | 73756 | 29362141 |
Prostate cancer | 11.09 | 9.87 | 72 | 138558 | 25455 | 29410442 |
Urobilinogen urine increased | 11.01 | 9.87 | 11 | 138619 | 361 | 29435536 |
Osteonecrosis | 10.94 | 9.87 | 30 | 138600 | 13489 | 29422408 |
Bronchial dysplasia | 10.93 | 9.87 | 5 | 138625 | 41 | 29435856 |
Protein urine | 10.93 | 9.87 | 16 | 138614 | 786 | 29435111 |
Chronic obstructive pulmonary disease | 10.93 | 9.87 | 131 | 138499 | 40824 | 29395073 |
Crohn's disease | 10.92 | 9.87 | 35 | 138595 | 2974 | 29432923 |
Areflexia | 10.88 | 9.87 | 33 | 138597 | 2721 | 29433176 |
Tooth infection | 10.79 | 9.87 | 53 | 138577 | 5486 | 29430411 |
General physical health deterioration | 10.78 | 9.87 | 384 | 138246 | 102473 | 29333424 |
Pharyngeal paraesthesia | 10.76 | 9.87 | 12 | 138618 | 448 | 29435449 |
Ultrasound liver abnormal | 10.75 | 9.87 | 7 | 138623 | 122 | 29435775 |
Sexual dysfunction | 10.74 | 9.87 | 7 | 138623 | 5807 | 29430090 |
Vessel puncture site bruise | 10.73 | 9.87 | 5 | 138625 | 43 | 29435854 |
Injection site reaction | 10.49 | 9.87 | 23 | 138607 | 11165 | 29424732 |
Ammonia increased | 10.45 | 9.87 | 42 | 138588 | 3989 | 29431908 |
Hallucinations, mixed | 10.42 | 9.87 | 30 | 138600 | 2403 | 29433494 |
Blood pressure decreased | 10.38 | 9.87 | 283 | 138347 | 45194 | 29390703 |
Alopecia | 10.38 | 9.87 | 50 | 138580 | 19034 | 29416863 |
Deep vein thrombosis | 10.36 | 9.87 | 198 | 138432 | 57201 | 29378696 |
Hypoxia | 10.30 | 9.87 | 293 | 138337 | 47086 | 29388811 |
Analgesic drug level above therapeutic | 10.27 | 9.87 | 9 | 138621 | 249 | 29435648 |
Product substitution issue | 10.22 | 9.87 | 17 | 138613 | 9155 | 29426742 |
Adverse event | 10.22 | 9.87 | 37 | 138593 | 15254 | 29420643 |
Haematocrit decreased | 10.20 | 9.87 | 192 | 138438 | 28830 | 29407067 |
Hypertriglyceridaemia | 10.18 | 9.87 | 12 | 138618 | 7463 | 29428434 |
Drug screen positive | 10.17 | 9.87 | 40 | 138590 | 3761 | 29432136 |
Hypoaesthesia | 10.09 | 9.87 | 183 | 138447 | 53284 | 29382613 |
Fall | 10.06 | 9.87 | 705 | 137925 | 176473 | 29259424 |
Specific gravity urine decreased | 9.99 | 9.87 | 6 | 138624 | 90 | 29435807 |
Enterocolitis infectious | 9.98 | 9.87 | 20 | 138610 | 1269 | 29434628 |
Intraocular pressure increased | 9.94 | 9.87 | 5 | 138625 | 4784 | 29431113 |
Hepatocellular carcinoma | 9.91 | 9.87 | 11 | 138619 | 7027 | 29428870 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 3931.74 | 9.93 | 5722 | 380953 | 218692 | 63893365 |
Toxicity to various agents | 2962.98 | 9.93 | 6640 | 380035 | 356873 | 63755184 |
Infusion related reaction | 1075.19 | 9.93 | 2764 | 383911 | 161703 | 63950354 |
Exposure to toxic agent | 793.48 | 9.93 | 482 | 386193 | 5677 | 64106380 |
Overdose | 754.93 | 9.93 | 2387 | 384288 | 157179 | 63954878 |
Acute hepatic failure | 721.69 | 9.93 | 836 | 385839 | 25276 | 64086781 |
Intentional product misuse | 691.51 | 9.93 | 1413 | 385262 | 70882 | 64041175 |
Blood pressure fluctuation | 672.43 | 9.93 | 1155 | 385520 | 50716 | 64061341 |
Intentional overdose | 395.49 | 9.93 | 1313 | 385362 | 88631 | 64023426 |
Metabolic acidosis | 389.28 | 9.93 | 1119 | 385556 | 69839 | 64042218 |
Rheumatoid arthritis | 362.52 | 9.93 | 1942 | 384733 | 162352 | 63949705 |
Product dose omission issue | 322.96 | 9.93 | 416 | 386259 | 194331 | 63917726 |
Hepatotoxicity | 305.57 | 9.93 | 714 | 385961 | 39248 | 64072809 |
Muscle injury | 289.28 | 9.93 | 547 | 386128 | 25890 | 64086167 |
Heart rate decreased | 283.42 | 9.93 | 849 | 385826 | 54218 | 64057839 |
Sinusitis | 276.35 | 9.93 | 1656 | 385019 | 144272 | 63967785 |
Folliculitis | 266.54 | 9.93 | 570 | 386105 | 29507 | 64082550 |
Anion gap | 263.58 | 9.93 | 155 | 386520 | 1712 | 64110345 |
Duodenal ulcer perforation | 260.75 | 9.93 | 615 | 386060 | 34010 | 64078047 |
Anti-cyclic citrullinated peptide antibody positive | 260.63 | 9.93 | 770 | 385905 | 48792 | 64063265 |
Irritable bowel syndrome | 255.00 | 9.93 | 639 | 386036 | 36730 | 64075327 |
Sleep disorder due to general medical condition, insomnia type | 252.83 | 9.93 | 515 | 386160 | 25755 | 64086302 |
Helicobacter infection | 245.22 | 9.93 | 640 | 386035 | 37722 | 64074335 |
Injection site pain | 229.44 | 9.93 | 198 | 386477 | 111210 | 64000847 |
Hepatic enzyme increased | 229.22 | 9.93 | 1448 | 385227 | 128495 | 63983562 |
Blood pressure increased | 225.07 | 9.93 | 1787 | 384888 | 170765 | 63941292 |
Respiratory arrest | 214.82 | 9.93 | 753 | 385922 | 52232 | 64059825 |
Hand deformity | 212.70 | 9.93 | 842 | 385833 | 61929 | 64050128 |
Lower respiratory tract infection | 212.33 | 9.93 | 1124 | 385551 | 93490 | 64018567 |
Cardio-respiratory arrest | 210.71 | 9.93 | 1154 | 385521 | 97239 | 64014818 |
Diarrhoea | 207.81 | 9.93 | 3068 | 383607 | 719636 | 63392421 |
Medication error | 205.09 | 9.93 | 713 | 385962 | 49253 | 64062804 |
Pemphigus | 199.08 | 9.93 | 806 | 385869 | 59895 | 64052162 |
Pericarditis | 197.84 | 9.93 | 821 | 385854 | 61695 | 64050362 |
Coagulopathy | 195.34 | 9.93 | 524 | 386151 | 31396 | 64080661 |
Intentional product use issue | 188.68 | 9.93 | 1095 | 385580 | 94269 | 64017788 |
Depressed level of consciousness | 178.99 | 9.93 | 962 | 385713 | 80474 | 64031583 |
Myocardial infarction | 176.16 | 9.93 | 465 | 386210 | 165356 | 63946701 |
Hepatic cytolysis | 175.65 | 9.93 | 308 | 386367 | 13741 | 64098316 |
Ill-defined disorder | 173.37 | 9.93 | 620 | 386055 | 43432 | 64068625 |
Nasopharyngitis | 171.03 | 9.93 | 1863 | 384812 | 194210 | 63917847 |
Hepatic necrosis | 169.71 | 9.93 | 231 | 386444 | 8242 | 64103815 |
Wound | 166.43 | 9.93 | 901 | 385774 | 75576 | 64036481 |
Glossodynia | 165.81 | 9.93 | 798 | 385877 | 63898 | 64048159 |
Anaemia | 164.36 | 9.93 | 1465 | 385210 | 377215 | 63734842 |
Oxygen saturation decreased | 158.80 | 9.93 | 1144 | 385531 | 106032 | 64006025 |
Blood pressure diastolic abnormal | 157.81 | 9.93 | 268 | 386407 | 11649 | 64100408 |
Blister | 155.82 | 9.93 | 923 | 385752 | 80044 | 64032013 |
Discomfort | 155.65 | 9.93 | 922 | 385753 | 79956 | 64032101 |
Cardiac failure congestive | 150.53 | 9.93 | 351 | 386324 | 130229 | 63981828 |
Analgesic drug level increased | 146.20 | 9.93 | 116 | 386559 | 2154 | 64109903 |
Injection site erythema | 143.12 | 9.93 | 128 | 386547 | 70672 | 64041385 |
Systemic lupus erythematosus | 142.49 | 9.93 | 874 | 385801 | 76738 | 64035319 |
Poisoning | 140.82 | 9.93 | 366 | 386309 | 21513 | 64090544 |
Joint swelling | 140.31 | 9.93 | 1937 | 384738 | 213445 | 63898612 |
Impaired healing | 137.40 | 9.93 | 721 | 385954 | 59752 | 64052305 |
Body temperature increased | 133.30 | 9.93 | 503 | 386172 | 36163 | 64075894 |
Liver injury | 133.28 | 9.93 | 439 | 386236 | 29493 | 64082564 |
Respiratory depression | 132.66 | 9.93 | 374 | 386301 | 23069 | 64088988 |
Drug resistance | 132.23 | 9.93 | 25 | 386650 | 35077 | 64076980 |
Sedation complication | 132.05 | 9.93 | 229 | 386446 | 10125 | 64101932 |
Synovitis | 130.06 | 9.93 | 1028 | 385647 | 98062 | 64013995 |
Blood pressure diastolic decreased | 126.41 | 9.93 | 356 | 386319 | 21945 | 64090112 |
Weight increased | 125.94 | 9.93 | 1886 | 384789 | 211462 | 63900595 |
Sopor | 125.76 | 9.93 | 15 | 386660 | 29646 | 64082411 |
Suspected suicide | 124.49 | 9.93 | 202 | 386473 | 8452 | 64103605 |
Blood pressure systolic increased | 123.12 | 9.93 | 605 | 386070 | 48848 | 64063209 |
Psoriasis | 122.04 | 9.93 | 150 | 386525 | 71553 | 64040504 |
Blood pressure systolic abnormal | 121.75 | 9.93 | 216 | 386459 | 9726 | 64102331 |
Drug interaction | 119.53 | 9.93 | 1493 | 385182 | 360590 | 63751467 |
Cardiac failure | 117.70 | 9.93 | 403 | 386272 | 131970 | 63980087 |
Wrong technique in product usage process | 113.69 | 9.93 | 133 | 386542 | 64841 | 64047216 |
Drug ineffective | 112.03 | 9.93 | 4019 | 382656 | 836228 | 63275829 |
Creatinine renal clearance decreased | 110.57 | 9.93 | 258 | 386417 | 14163 | 64097894 |
Heart rate increased | 110.53 | 9.93 | 988 | 385687 | 97687 | 64014370 |
Therapeutic product effect decreased | 108.92 | 9.93 | 1114 | 385561 | 114237 | 63997820 |
Death | 108.46 | 9.93 | 3718 | 382957 | 478987 | 63633070 |
Hepatic failure | 108.18 | 9.93 | 634 | 386041 | 54760 | 64057297 |
Accidental overdose | 104.81 | 9.93 | 439 | 386236 | 33118 | 64078939 |
Heart rate irregular | 104.61 | 9.93 | 382 | 386293 | 27031 | 64085026 |
Blood calcium decreased | 104.27 | 9.93 | 364 | 386311 | 25190 | 64086867 |
Substance abuse | 102.55 | 9.93 | 193 | 386482 | 9099 | 64102958 |
Arthropathy | 100.18 | 9.93 | 1138 | 385537 | 119829 | 63992228 |
Device expulsion | 99.46 | 9.93 | 7 | 386668 | 21129 | 64090928 |
Exposure via ingestion | 98.72 | 9.93 | 134 | 386541 | 4768 | 64107289 |
Throat irritation | 97.57 | 9.93 | 422 | 386253 | 32289 | 64079768 |
Bone marrow failure | 96.54 | 9.93 | 87 | 386588 | 47865 | 64064192 |
Injection site pruritus | 95.32 | 9.93 | 54 | 386621 | 37772 | 64074285 |
Osteonecrosis of jaw | 94.56 | 9.93 | 61 | 386614 | 39764 | 64072293 |
Acute lung injury | 93.74 | 9.93 | 98 | 386577 | 2633 | 64109424 |
Injection site reaction | 92.36 | 9.93 | 86 | 386589 | 46578 | 64065479 |
Neutropenia | 91.53 | 9.93 | 956 | 385719 | 238668 | 63873389 |
Swelling | 90.51 | 9.93 | 1406 | 385269 | 158812 | 63953245 |
Interstitial lung disease | 89.28 | 9.93 | 294 | 386381 | 97438 | 64014619 |
Injection site swelling | 85.70 | 9.93 | 73 | 386602 | 41280 | 64070777 |
Pyroglutamic acidosis | 85.66 | 9.93 | 54 | 386621 | 682 | 64111375 |
Hypotension | 85.60 | 9.93 | 2935 | 383740 | 378039 | 63734018 |
Disease progression | 83.01 | 9.93 | 503 | 386172 | 141177 | 63970880 |
Product use in unapproved indication | 81.95 | 9.93 | 671 | 386004 | 175947 | 63936110 |
Gastrointestinal disorder | 80.25 | 9.93 | 857 | 385818 | 88852 | 64023205 |
Injection site bruising | 76.87 | 9.93 | 63 | 386612 | 36310 | 64075747 |
Coma | 75.59 | 9.93 | 831 | 385844 | 86784 | 64025273 |
Body temperature decreased | 75.43 | 9.93 | 332 | 386343 | 25596 | 64086461 |
Cognitive disorder | 74.18 | 9.93 | 575 | 386100 | 54512 | 64057545 |
Hospitalisation | 73.80 | 9.93 | 219 | 386456 | 74988 | 64037069 |
Alanine aminotransferase increased | 73.21 | 9.93 | 1206 | 385469 | 137825 | 63974232 |
Product prescribing error | 72.19 | 9.93 | 63 | 386612 | 35206 | 64076851 |
Malignant neoplasm progression | 70.23 | 9.93 | 393 | 386282 | 112478 | 63999579 |
Renal impairment | 70.15 | 9.93 | 497 | 386178 | 134520 | 63977537 |
Neuropathy peripheral | 70.02 | 9.93 | 415 | 386260 | 117110 | 63994947 |
Decreased appetite | 69.77 | 9.93 | 1226 | 385449 | 280063 | 63831994 |
Pancytopenia | 68.99 | 9.93 | 539 | 386136 | 142770 | 63969287 |
Therapeutic product effect incomplete | 68.43 | 9.93 | 353 | 386322 | 103129 | 64008928 |
Blood pressure diastolic increased | 68.30 | 9.93 | 179 | 386496 | 10573 | 64101484 |
Coronary artery disease | 66.79 | 9.93 | 166 | 386509 | 60267 | 64051790 |
Pneumonia | 66.68 | 9.93 | 2711 | 383964 | 556865 | 63555192 |
Ear pain | 65.06 | 9.93 | 311 | 386364 | 24825 | 64087232 |
Hypersensitivity | 63.38 | 9.93 | 1584 | 385091 | 194868 | 63917189 |
Mucosal inflammation | 63.04 | 9.93 | 180 | 386495 | 62404 | 64049653 |
Therapy cessation | 62.98 | 9.93 | 61 | 386614 | 32428 | 64079629 |
Neutrophil percentage increased | 62.91 | 9.93 | 103 | 386572 | 4342 | 64107715 |
Pyroglutamate increased | 61.87 | 9.93 | 42 | 386633 | 606 | 64111451 |
Cerebrovascular accident | 61.86 | 9.93 | 527 | 386148 | 137056 | 63975001 |
Dyspnoea | 61.13 | 9.93 | 3607 | 383068 | 715067 | 63396990 |
Acute kidney injury | 60.19 | 9.93 | 2146 | 384529 | 447094 | 63664963 |
Sedation | 59.31 | 9.93 | 439 | 386236 | 41023 | 64071034 |
Contraindicated product administered | 59.24 | 9.93 | 942 | 385733 | 106887 | 64005170 |
Respiratory rate increased | 58.95 | 9.93 | 242 | 386433 | 18089 | 64093968 |
Anion gap abnormal | 58.83 | 9.93 | 38 | 386637 | 502 | 64111555 |
Oedema peripheral | 58.27 | 9.93 | 898 | 385777 | 209419 | 63902638 |
Crystal urine present | 57.07 | 9.93 | 64 | 386611 | 1865 | 64110192 |
Rheumatoid factor positive | 57.04 | 9.93 | 382 | 386293 | 34556 | 64077501 |
White blood cells urine positive | 56.96 | 9.93 | 110 | 386565 | 5288 | 64106769 |
Injection site warmth | 56.60 | 9.93 | 7 | 386668 | 13455 | 64098602 |
Drug abuse | 55.84 | 9.93 | 1109 | 385566 | 131265 | 63980792 |
Electric shock | 54.77 | 9.93 | 49 | 386626 | 1080 | 64110977 |
Urine abnormality | 54.58 | 9.93 | 130 | 386545 | 7232 | 64104825 |
Lymphocyte percentage decreased | 54.36 | 9.93 | 99 | 386576 | 4550 | 64107507 |
Suicide attempt | 54.31 | 9.93 | 658 | 386017 | 70349 | 64041708 |
Aspartate aminotransferase increased | 52.70 | 9.93 | 1010 | 385665 | 118778 | 63993279 |
Blood pH decreased | 51.80 | 9.93 | 94 | 386581 | 4308 | 64107749 |
Diabetes mellitus | 51.50 | 9.93 | 214 | 386461 | 66260 | 64045797 |
Cardiac arrest | 51.10 | 9.93 | 1247 | 385428 | 152817 | 63959240 |
Drug ineffective for unapproved indication | 51.02 | 9.93 | 67 | 386608 | 31066 | 64080991 |
Dizziness | 50.74 | 9.93 | 2086 | 384589 | 428077 | 63683980 |
Therapeutic response shortened | 50.60 | 9.93 | 155 | 386520 | 10015 | 64102042 |
International normalised ratio increased | 50.25 | 9.93 | 709 | 385966 | 78458 | 64033599 |
Leukopenia | 49.54 | 9.93 | 379 | 386296 | 100863 | 64011194 |
Septic shock | 49.14 | 9.93 | 400 | 386275 | 105037 | 64007020 |
Body temperature fluctuation | 48.83 | 9.93 | 78 | 386597 | 3220 | 64108837 |
Hyperkalaemia | 48.35 | 9.93 | 381 | 386294 | 100748 | 64011309 |
Poor venous access | 48.19 | 9.93 | 174 | 386501 | 12243 | 64099814 |
Arthralgia | 47.16 | 9.93 | 3165 | 383510 | 439095 | 63672962 |
Cerebral haemorrhage | 47.12 | 9.93 | 153 | 386522 | 50937 | 64061120 |
Cytokine release syndrome | 47.06 | 9.93 | 248 | 386427 | 20581 | 64091476 |
Posterior reversible encephalopathy syndrome | 46.94 | 9.93 | 41 | 386634 | 22905 | 64089152 |
Neoplasm progression | 46.46 | 9.93 | 111 | 386564 | 40853 | 64071204 |
Product quality issue | 45.96 | 9.93 | 67 | 386608 | 29732 | 64082325 |
Myelosuppression | 45.89 | 9.93 | 45 | 386630 | 23785 | 64088272 |
Feeling abnormal | 45.44 | 9.93 | 547 | 386128 | 133055 | 63979002 |
Palmar-plantar erythrodysaesthesia syndrome | 45.23 | 9.93 | 64 | 386611 | 28755 | 64083302 |
Epistaxis | 44.04 | 9.93 | 376 | 386299 | 97755 | 64014302 |
Drug hypersensitivity | 43.74 | 9.93 | 1088 | 385587 | 236727 | 63875330 |
Cytomegalovirus infection | 43.63 | 9.93 | 99 | 386576 | 37100 | 64074957 |
Stomatitis | 43.16 | 9.93 | 909 | 385766 | 108696 | 64003361 |
Injection site mass | 43.02 | 9.93 | 25 | 386650 | 17245 | 64094812 |
Dyspnoea exertional | 42.51 | 9.93 | 263 | 386412 | 73467 | 64038590 |
Muscle spasticity | 42.24 | 9.93 | 205 | 386470 | 16464 | 64095593 |
Prothrombin time prolonged | 41.64 | 9.93 | 196 | 386479 | 15545 | 64096512 |
Hyperlipidaemia | 41.30 | 9.93 | 46 | 386629 | 22930 | 64089127 |
Haematotoxicity | 41.14 | 9.93 | 13 | 386662 | 12883 | 64099174 |
Acute myocardial infarction | 41.08 | 9.93 | 247 | 386428 | 69471 | 64042586 |
Underdose | 40.89 | 9.93 | 57 | 386618 | 25772 | 64086285 |
Brain death | 40.63 | 9.93 | 90 | 386585 | 4771 | 64107286 |
Gait disturbance | 40.53 | 9.93 | 757 | 385918 | 171398 | 63940659 |
Product substitution issue | 40.20 | 9.93 | 29 | 386646 | 17832 | 64094225 |
Muscle spasms | 39.76 | 9.93 | 600 | 386075 | 140423 | 63971634 |
Infusion site extravasation | 39.59 | 9.93 | 110 | 386565 | 6727 | 64105330 |
Dehydration | 39.50 | 9.93 | 993 | 385682 | 215770 | 63896287 |
Memory impairment | 39.49 | 9.93 | 326 | 386349 | 85356 | 64026701 |
Atrial fibrillation | 39.45 | 9.93 | 755 | 385920 | 170334 | 63941723 |
Lymphocyte count decreased | 39.31 | 9.93 | 395 | 386280 | 40304 | 64071753 |
Surgery | 39.19 | 9.93 | 68 | 386607 | 28145 | 64083912 |
Pain | 39.07 | 9.93 | 3838 | 382837 | 549673 | 63562384 |
Immune reconstitution inflammatory syndrome | 39.02 | 9.93 | 13 | 386662 | 12457 | 64099600 |
Visual acuity reduced | 39.01 | 9.93 | 64 | 386611 | 27077 | 64084980 |
Urinary sediment present | 38.95 | 9.93 | 57 | 386618 | 2177 | 64109880 |
Injection site rash | 38.91 | 9.93 | 23 | 386652 | 15719 | 64096338 |
Peripheral swelling | 38.82 | 9.93 | 1578 | 385097 | 207575 | 63904482 |
Red cell distribution width increased | 38.41 | 9.93 | 161 | 386514 | 12148 | 64099909 |
Flushing | 38.38 | 9.93 | 674 | 386001 | 77974 | 64034083 |
Product storage error | 38.13 | 9.93 | 16 | 386659 | 13302 | 64098755 |
Orthostatic hypotension | 37.90 | 9.93 | 438 | 386237 | 46300 | 64065757 |
Asthenia | 37.58 | 9.93 | 2141 | 384534 | 425903 | 63686154 |
Renal failure | 37.08 | 9.93 | 818 | 385857 | 180870 | 63931187 |
Injection site haemorrhage | 37.03 | 9.93 | 55 | 386620 | 24223 | 64087834 |
Diabetic ketoacidosis | 37.01 | 9.93 | 77 | 386598 | 29768 | 64082289 |
Device issue | 36.85 | 9.93 | 49 | 386626 | 22599 | 64089458 |
Contusion | 36.74 | 9.93 | 919 | 385756 | 113046 | 63999011 |
Rheumatic fever | 36.72 | 9.93 | 131 | 386544 | 9163 | 64102894 |
Infusion site pain | 36.44 | 9.93 | 141 | 386534 | 10256 | 64101801 |
Red blood cell sedimentation rate abnormal | 36.02 | 9.93 | 27 | 386648 | 16279 | 64095778 |
Pathogen resistance | 36.02 | 9.93 | 15 | 386660 | 12528 | 64099529 |
Anion gap increased | 35.82 | 9.93 | 65 | 386610 | 2979 | 64109078 |
Cerebral infarction | 35.75 | 9.93 | 126 | 386549 | 40918 | 64071139 |
Urine leukocyte esterase positive | 35.48 | 9.93 | 69 | 386606 | 3334 | 64108723 |
Therapy interrupted | 35.06 | 9.93 | 41 | 386634 | 19995 | 64092062 |
Malaise | 34.58 | 9.93 | 1983 | 384692 | 394264 | 63717793 |
Injection site induration | 34.42 | 9.93 | 6 | 386669 | 8926 | 64103131 |
Extrapyramidal disorder | 34.22 | 9.93 | 40 | 386635 | 19512 | 64092545 |
Haemolysis | 34.14 | 9.93 | 144 | 386531 | 10895 | 64101162 |
Jaundice cholestatic | 34.08 | 9.93 | 122 | 386553 | 8548 | 64103509 |
Myelodysplastic syndrome | 33.49 | 9.93 | 72 | 386603 | 27507 | 64084550 |
Fall | 33.19 | 9.93 | 2104 | 384571 | 414722 | 63697335 |
Thrombocytopenia | 33.19 | 9.93 | 1055 | 385620 | 222746 | 63889311 |
Device malfunction | 33.15 | 9.93 | 34 | 386641 | 17599 | 64094458 |
Acidosis | 33.02 | 9.93 | 201 | 386474 | 17594 | 64094463 |
Device difficult to use | 32.86 | 9.93 | 9 | 386666 | 9789 | 64102268 |
Loss of personal independence in daily activities | 32.79 | 9.93 | 277 | 386398 | 72177 | 64039880 |
Labelled drug-drug interaction medication error | 32.67 | 9.93 | 51 | 386624 | 22011 | 64090046 |
Urticaria | 32.49 | 9.93 | 1133 | 385542 | 146184 | 63965873 |
Unresponsive to stimuli | 32.25 | 9.93 | 452 | 386223 | 49941 | 64062116 |
Specific gravity urine decreased | 32.21 | 9.93 | 31 | 386644 | 752 | 64111305 |
Analgesic drug level above therapeutic | 31.93 | 9.93 | 24 | 386651 | 410 | 64111647 |
Full blood count abnormal | 31.90 | 9.93 | 83 | 386592 | 29674 | 64082383 |
Post transplant lymphoproliferative disorder | 31.57 | 9.93 | 9 | 386666 | 9535 | 64102522 |
Electrocardiogram QT prolonged | 31.50 | 9.93 | 314 | 386361 | 79134 | 64032923 |
General physical health deterioration | 31.44 | 9.93 | 959 | 385716 | 203466 | 63908591 |
Infusion site pruritus | 31.12 | 9.93 | 56 | 386619 | 2550 | 64109507 |
Renal papillary necrosis | 31.02 | 9.93 | 22 | 386653 | 342 | 64111715 |
Red blood cells urine positive | 30.98 | 9.93 | 77 | 386598 | 4401 | 64107656 |
Infusion site swelling | 30.73 | 9.93 | 87 | 386588 | 5378 | 64106679 |
Night sweats | 30.67 | 9.93 | 341 | 386334 | 35705 | 64076352 |
Paraesthesia | 30.59 | 9.93 | 595 | 386080 | 133927 | 63978130 |
Blood parathyroid hormone decreased | 30.56 | 9.93 | 4 | 386671 | 7362 | 64104695 |
Second primary malignancy | 30.53 | 9.93 | 18 | 386657 | 12319 | 64099738 |
No adverse event | 30.36 | 9.93 | 80 | 386595 | 28481 | 64083576 |
Unevaluable event | 30.20 | 9.93 | 178 | 386497 | 50311 | 64061746 |
Syncope | 30.11 | 9.93 | 717 | 385958 | 156918 | 63955139 |
Drug screen positive | 30.09 | 9.93 | 89 | 386586 | 5640 | 64106417 |
Glycosylated haemoglobin increased | 29.99 | 9.93 | 31 | 386644 | 15988 | 64096069 |
Haematuria | 29.75 | 9.93 | 226 | 386449 | 60245 | 64051812 |
Unintentional medical device removal | 29.57 | 9.93 | 3 | 386672 | 6731 | 64105326 |
Brain oedema | 29.47 | 9.93 | 230 | 386445 | 21845 | 64090212 |
Gastrointestinal haemorrhage | 29.24 | 9.93 | 588 | 386087 | 131724 | 63980333 |
Ear pruritus | 29.04 | 9.93 | 55 | 386620 | 2605 | 64109452 |
Lactic acidosis | 28.59 | 9.93 | 233 | 386442 | 61177 | 64050880 |
Hypertensive crisis | 28.17 | 9.93 | 41 | 386634 | 18207 | 64093850 |
Sexual dysfunction | 28.12 | 9.93 | 3 | 386672 | 6468 | 64105589 |
Precancerous cells present | 27.56 | 9.93 | 32 | 386643 | 969 | 64111088 |
C-reactive protein abnormal | 27.48 | 9.93 | 86 | 386589 | 28961 | 64083096 |
Bacterial test | 27.41 | 9.93 | 35 | 386640 | 1172 | 64110885 |
Transient ischaemic attack | 27.38 | 9.93 | 154 | 386521 | 44028 | 64068029 |
Drug intolerance | 27.17 | 9.93 | 1383 | 385292 | 186609 | 63925448 |
Urine analysis abnormal | 27.04 | 9.93 | 86 | 386589 | 5670 | 64106387 |
Liver transplant | 26.89 | 9.93 | 69 | 386606 | 4023 | 64108034 |
Lung neoplasm malignant | 26.88 | 9.93 | 55 | 386620 | 21393 | 64090664 |
Device dislocation | 26.81 | 9.93 | 54 | 386621 | 21124 | 64090933 |
Injection site urticaria | 26.71 | 9.93 | 17 | 386658 | 11164 | 64100893 |
Infusion site erythema | 26.41 | 9.93 | 96 | 386579 | 6777 | 64105280 |
Aplastic anaemia | 26.32 | 9.93 | 158 | 386517 | 13762 | 64098295 |
Psoriatic arthropathy | 26.20 | 9.93 | 152 | 386523 | 43129 | 64068928 |
Hypocalcaemia | 26.16 | 9.93 | 145 | 386530 | 41608 | 64070449 |
Bilirubin urine present | 25.96 | 9.93 | 19 | 386656 | 311 | 64111746 |
Epilepsy | 25.93 | 9.93 | 108 | 386567 | 33423 | 64078634 |
Swollen joint count increased | 25.91 | 9.93 | 103 | 386572 | 7586 | 64104471 |
Abdominal discomfort | 25.88 | 9.93 | 1339 | 385336 | 180983 | 63931074 |
Acute graft versus host disease | 25.87 | 9.93 | 11 | 386664 | 9073 | 64102984 |
Forced expiratory volume decreased | 25.63 | 9.93 | 5 | 386670 | 6862 | 64105195 |
Graft versus host disease | 25.56 | 9.93 | 27 | 386648 | 13786 | 64098271 |
Soft tissue disorder | 25.54 | 9.93 | 59 | 386616 | 3217 | 64108840 |
Myalgia | 25.40 | 9.93 | 740 | 385935 | 157877 | 63954180 |
Iron deficiency anaemia | 25.07 | 9.93 | 59 | 386616 | 21830 | 64090227 |
Nausea | 24.98 | 9.93 | 4237 | 382438 | 781563 | 63330494 |
Full blood count decreased | 24.97 | 9.93 | 62 | 386613 | 22520 | 64089537 |
Inappropriate antidiuretic hormone secretion | 24.80 | 9.93 | 61 | 386614 | 22228 | 64089829 |
Confusional state | 24.67 | 9.93 | 1851 | 384824 | 259293 | 63852764 |
Cardiac failure chronic | 24.11 | 9.93 | 12 | 386663 | 9029 | 64103028 |
Bursitis | 23.97 | 9.93 | 215 | 386460 | 21270 | 64090787 |
Pneumocystis jirovecii pneumonia | 23.95 | 9.93 | 85 | 386590 | 27549 | 64084508 |
Pruritus | 23.88 | 9.93 | 2179 | 384496 | 310221 | 63801836 |
Multiple drug therapy | 23.86 | 9.93 | 46 | 386629 | 2208 | 64109849 |
Drug-induced liver injury | 23.85 | 9.93 | 410 | 386265 | 47233 | 64064824 |
Coronary arterial stent insertion | 23.83 | 9.93 | 3 | 386672 | 5689 | 64106368 |
Prostate cancer | 23.77 | 9.93 | 52 | 386623 | 19743 | 64092314 |
Multiple-drug resistance | 23.71 | 9.93 | 5 | 386670 | 6497 | 64105560 |
Osteonecrosis | 23.70 | 9.93 | 88 | 386587 | 28141 | 64083916 |
Angina unstable | 23.63 | 9.93 | 35 | 386640 | 15432 | 64096625 |
Granuloma skin | 23.58 | 9.93 | 4 | 386671 | 6070 | 64105987 |
Hepatic cirrhosis | 23.39 | 9.93 | 80 | 386595 | 26218 | 64085839 |
Smear cervix abnormal | 23.38 | 9.93 | 47 | 386628 | 2327 | 64109730 |
Cardiomyopathy | 23.33 | 9.93 | 76 | 386599 | 25280 | 64086777 |
Hypomagnesaemia | 23.31 | 9.93 | 130 | 386545 | 37246 | 64074811 |
Renal cortical necrosis | 23.24 | 9.93 | 17 | 386658 | 278 | 64111779 |
Rash pruritic | 23.12 | 9.93 | 226 | 386449 | 57178 | 64054879 |
Angina pectoris | 22.88 | 9.93 | 167 | 386508 | 44914 | 64067143 |
Mobility decreased | 22.50 | 9.93 | 674 | 386001 | 85166 | 64026891 |
Depression | 22.37 | 9.93 | 885 | 385790 | 182406 | 63929651 |
Culture urine positive | 22.29 | 9.93 | 65 | 386610 | 4086 | 64107971 |
Hyponatraemia | 22.28 | 9.93 | 698 | 385977 | 147641 | 63964416 |
Acute myeloid leukaemia | 22.16 | 9.93 | 87 | 386588 | 27376 | 64084681 |
Cardiac failure acute | 22.15 | 9.93 | 40 | 386635 | 16304 | 64095753 |
Endophthalmitis | 22.05 | 9.93 | 3 | 386672 | 5362 | 64106695 |
Disturbance in attention | 21.90 | 9.93 | 150 | 386525 | 40924 | 64071133 |
Hypomania | 21.74 | 9.93 | 79 | 386596 | 5575 | 64106482 |
Blood urine present | 21.74 | 9.93 | 186 | 386489 | 18154 | 64093903 |
Polyneuropathy | 21.70 | 9.93 | 55 | 386620 | 19839 | 64092218 |
Transaminases increased | 21.69 | 9.93 | 382 | 386293 | 44212 | 64067845 |
Hepatic encephalopathy | 21.58 | 9.93 | 207 | 386468 | 20859 | 64091198 |
Infusion site mass | 21.57 | 9.93 | 28 | 386647 | 953 | 64111104 |
Haemorrhage | 21.54 | 9.93 | 340 | 386335 | 79011 | 64033046 |
Hypercalcaemia | 21.42 | 9.93 | 106 | 386569 | 31310 | 64080747 |
Monocyte percentage increased | 21.40 | 9.93 | 41 | 386634 | 1959 | 64110098 |
Aspergillus infection | 21.39 | 9.93 | 41 | 386634 | 16338 | 64095719 |
Haematochezia | 21.33 | 9.93 | 275 | 386400 | 66098 | 64045959 |
Status epilepticus | 21.30 | 9.93 | 63 | 386612 | 21600 | 64090457 |
Drug level below therapeutic | 21.06 | 9.93 | 94 | 386581 | 7290 | 64104767 |
Angioedema | 21.05 | 9.93 | 253 | 386422 | 61568 | 64050489 |
Febrile bone marrow aplasia | 20.82 | 9.93 | 22 | 386653 | 11233 | 64100824 |
Temperature regulation disorder | 20.78 | 9.93 | 64 | 386611 | 4147 | 64107910 |
Seizure | 20.76 | 9.93 | 804 | 385871 | 166088 | 63945969 |
Thrombotic microangiopathy | 20.63 | 9.93 | 43 | 386632 | 16612 | 64095445 |
Sepsis | 20.55 | 9.93 | 1150 | 385525 | 229191 | 63882866 |
Basal cell carcinoma | 20.48 | 9.93 | 105 | 386570 | 30733 | 64081324 |
Ageusia | 20.39 | 9.93 | 32 | 386643 | 13781 | 64098276 |
Dry skin | 20.36 | 9.93 | 202 | 386473 | 50959 | 64061098 |
Intervertebral discitis | 20.34 | 9.93 | 60 | 386615 | 3797 | 64108260 |
Environmental exposure | 20.33 | 9.93 | 17 | 386658 | 341 | 64111716 |
Appendicolith | 20.27 | 9.93 | 56 | 386619 | 3413 | 64108644 |
Platelet count decreased | 20.20 | 9.93 | 811 | 385864 | 166900 | 63945157 |
Oedema | 20.18 | 9.93 | 409 | 386266 | 91526 | 64020531 |
Cytopenia | 19.97 | 9.93 | 39 | 386636 | 15432 | 64096625 |
Asthma | 19.91 | 9.93 | 427 | 386248 | 94798 | 64017259 |
Spinal stenosis | 19.88 | 9.93 | 33 | 386642 | 13898 | 64098159 |
Granulomatosis with polyangiitis | 19.73 | 9.93 | 41 | 386634 | 2079 | 64109978 |
Maternal exposure during pregnancy | 19.55 | 9.93 | 731 | 385944 | 95153 | 64016904 |
Blood creatinine decreased | 19.54 | 9.93 | 89 | 386586 | 6961 | 64105096 |
Transplant dysfunction | 19.30 | 9.93 | 8 | 386667 | 6700 | 64105357 |
Myopathy | 19.19 | 9.93 | 49 | 386626 | 17631 | 64094426 |
Vision blurred | 19.17 | 9.93 | 404 | 386271 | 89912 | 64022145 |
Transplant rejection | 19.06 | 9.93 | 48 | 386627 | 17353 | 64094704 |
Loss of consciousness | 19.06 | 9.93 | 712 | 385963 | 147653 | 63964404 |
Bone erosion | 18.95 | 9.93 | 25 | 386650 | 11570 | 64100487 |
Pharyngeal paraesthesia | 18.94 | 9.93 | 38 | 386637 | 1879 | 64110178 |
Subdural haematoma | 18.93 | 9.93 | 95 | 386580 | 27959 | 64084098 |
Chills | 18.85 | 9.93 | 1005 | 385670 | 136259 | 63975798 |
Hypothermia | 18.83 | 9.93 | 192 | 386483 | 19664 | 64092393 |
Cardiac disorder | 18.78 | 9.93 | 229 | 386446 | 55587 | 64056470 |
Pain in extremity | 18.73 | 9.93 | 1563 | 385112 | 301522 | 63810535 |
Neurotoxicity | 18.38 | 9.93 | 93 | 386582 | 27311 | 64084746 |
Coronary artery bypass | 18.31 | 9.93 | 6 | 386669 | 5809 | 64106248 |
Toxic epidermal necrolysis | 18.30 | 9.93 | 319 | 386356 | 36847 | 64075210 |
Bacterial test positive | 18.21 | 9.93 | 84 | 386591 | 6606 | 64105451 |
PCO2 decreased | 18.11 | 9.93 | 48 | 386627 | 2854 | 64109203 |
Right ventricular failure | 17.98 | 9.93 | 67 | 386608 | 21404 | 64090653 |
Methaemoglobinaemia | 17.79 | 9.93 | 62 | 386613 | 4286 | 64107771 |
Urine bilirubin decreased | 17.72 | 9.93 | 11 | 386664 | 135 | 64111922 |
Akathisia | 17.63 | 9.93 | 26 | 386649 | 11484 | 64100573 |
Osmolar gap | 17.51 | 9.93 | 11 | 386664 | 138 | 64111919 |
Prostatic specific antigen increased | 17.50 | 9.93 | 16 | 386659 | 8744 | 64103313 |
Fracture | 17.41 | 9.93 | 56 | 386619 | 18699 | 64093358 |
Burning sensation | 17.39 | 9.93 | 202 | 386473 | 49462 | 64062595 |
Agranulocytosis | 17.36 | 9.93 | 146 | 386529 | 38083 | 64073974 |
Metastases to lymph nodes | 17.32 | 9.93 | 16 | 386659 | 8701 | 64103356 |
Chronic graft versus host disease | 17.24 | 9.93 | 8 | 386667 | 6268 | 64105789 |
Infusion site bruising | 17.13 | 9.93 | 32 | 386643 | 1500 | 64110557 |
Maternal exposure timing unspecified | 17.12 | 9.93 | 45 | 386630 | 2662 | 64109395 |
Fluid retention | 16.99 | 9.93 | 253 | 386422 | 59353 | 64052704 |
Cells in urine | 16.89 | 9.93 | 12 | 386663 | 187 | 64111870 |
Sputum culture positive | 16.85 | 9.93 | 48 | 386627 | 2978 | 64109079 |
Panniculitis | 16.83 | 9.93 | 17 | 386658 | 8862 | 64103195 |
Thrombosis | 16.80 | 9.93 | 310 | 386365 | 70332 | 64041725 |
Inappropriate schedule of product administration | 16.80 | 9.93 | 695 | 385980 | 91591 | 64020466 |
Rhabdomyolysis | 16.74 | 9.93 | 420 | 386255 | 91306 | 64020751 |
COVID-19 immunisation | 16.72 | 9.93 | 19 | 386656 | 562 | 64111495 |
Mean cell haemoglobin concentration increased | 16.59 | 9.93 | 22 | 386653 | 765 | 64111292 |
Chronic obstructive pulmonary disease | 16.52 | 9.93 | 313 | 386362 | 70735 | 64041322 |
Deep vein thrombosis | 16.51 | 9.93 | 492 | 386183 | 104690 | 64007367 |
Pulmonary arterial hypertension | 16.50 | 9.93 | 87 | 386588 | 25280 | 64086777 |
Band neutrophil count increased | 16.49 | 9.93 | 20 | 386655 | 635 | 64111422 |
Brain scan abnormal | 16.44 | 9.93 | 27 | 386648 | 1141 | 64110916 |
Blood triglycerides increased | 16.37 | 9.93 | 58 | 386617 | 18808 | 64093249 |
Mean cell haemoglobin concentration decreased | 16.37 | 9.93 | 54 | 386621 | 3630 | 64108427 |
White blood cell count decreased | 16.36 | 9.93 | 776 | 385899 | 157061 | 63954996 |
Therapeutic response unexpected | 16.32 | 9.93 | 50 | 386625 | 16951 | 64095106 |
Speech disorder | 16.20 | 9.93 | 199 | 386476 | 48242 | 64063815 |
Tachycardia | 16.15 | 9.93 | 1072 | 385603 | 148507 | 63963550 |
Chronic kidney disease | 16.12 | 9.93 | 247 | 386428 | 57672 | 64054385 |
Pulmonary hypertension | 16.07 | 9.93 | 173 | 386502 | 42966 | 64069091 |
Hepatocellular carcinoma | 16.03 | 9.93 | 16 | 386659 | 8387 | 64103670 |
Abortion spontaneous | 15.92 | 9.93 | 87 | 386588 | 25056 | 64087001 |
Tremor | 15.92 | 9.93 | 726 | 385949 | 147504 | 63964553 |
Suicidal ideation | 15.83 | 9.93 | 292 | 386383 | 66250 | 64045807 |
Pulmonary mass | 15.82 | 9.93 | 82 | 386593 | 23934 | 64088123 |
Pain in jaw | 15.77 | 9.93 | 162 | 386513 | 40593 | 64071464 |
Alopecia | 15.73 | 9.93 | 1175 | 385500 | 164515 | 63947542 |
Aphasia | 15.66 | 9.93 | 163 | 386512 | 40743 | 64071314 |
Haematocrit decreased | 15.66 | 9.93 | 434 | 386241 | 54221 | 64057836 |
Withdrawal syndrome | 15.60 | 9.93 | 80 | 386595 | 23412 | 64088645 |
Anaphylactic shock | 15.56 | 9.93 | 112 | 386563 | 30216 | 64081841 |
Toxicologic test abnormal | 15.50 | 9.93 | 27 | 386648 | 1198 | 64110859 |
Sinus node dysfunction | 15.48 | 9.93 | 11 | 386664 | 6817 | 64105240 |
Device leakage | 15.47 | 9.93 | 16 | 386659 | 8250 | 64103807 |
Hepatocellular injury | 15.44 | 9.93 | 185 | 386490 | 45050 | 64067007 |
Cholecystitis chronic | 15.43 | 9.93 | 102 | 386573 | 9185 | 64102872 |
Food allergy | 15.41 | 9.93 | 90 | 386585 | 7761 | 64104296 |
Serum sickness | 15.31 | 9.93 | 48 | 386627 | 3141 | 64108916 |
Diffuse large B-cell lymphoma | 15.29 | 9.93 | 24 | 386651 | 10337 | 64101720 |
Abnormal dreams | 15.28 | 9.93 | 24 | 386651 | 10332 | 64101725 |
Fibromyalgia | 15.27 | 9.93 | 300 | 386375 | 35431 | 64076626 |
Congestive cardiomyopathy | 15.23 | 9.93 | 24 | 386651 | 10320 | 64101737 |
Prescribed underdose | 15.22 | 9.93 | 56 | 386619 | 17959 | 64094098 |
Candida infection | 15.18 | 9.93 | 118 | 386557 | 31301 | 64080756 |
Accidental death | 15.14 | 9.93 | 53 | 386622 | 3672 | 64108385 |
Cytomegalovirus viraemia | 15.13 | 9.93 | 26 | 386649 | 10802 | 64101255 |
Actinic keratosis | 15.12 | 9.93 | 6 | 386669 | 5159 | 64106898 |
Metastases to liver | 15.08 | 9.93 | 83 | 386592 | 23858 | 64088199 |
Hallucination | 15.04 | 9.93 | 327 | 386348 | 72461 | 64039596 |
Thinking abnormal | 15.03 | 9.93 | 29 | 386646 | 11527 | 64100530 |
Haemoglobin urine present | 15.02 | 9.93 | 22 | 386653 | 841 | 64111216 |
Eosinophil percentage increased | 15.00 | 9.93 | 29 | 386646 | 1395 | 64110662 |
Product monitoring error | 14.91 | 9.93 | 7 | 386668 | 5447 | 64106610 |
Lipodystrophy acquired | 14.89 | 9.93 | 3 | 386672 | 4024 | 64108033 |
Nocardiosis | 14.86 | 9.93 | 5 | 386670 | 4762 | 64107295 |
Epstein-Barr virus infection | 14.84 | 9.93 | 33 | 386642 | 12455 | 64099602 |
Lymphoproliferative disorder | 14.82 | 9.93 | 6 | 386669 | 5097 | 64106960 |
Skin exfoliation | 14.78 | 9.93 | 185 | 386490 | 44700 | 64067357 |
Oesophageal carcinoma | 14.75 | 9.93 | 5 | 386670 | 4738 | 64107319 |
Oxygen saturation abnormal | 14.68 | 9.93 | 51 | 386624 | 3520 | 64108537 |
Hypertriglyceridaemia | 14.67 | 9.93 | 28 | 386647 | 11177 | 64100880 |
Dyspnoea at rest | 14.61 | 9.93 | 10 | 386665 | 6319 | 64105738 |
Enthesopathy | 14.54 | 9.93 | 22 | 386653 | 9616 | 64102441 |
Anti-erythrocyte antibody positive | 14.54 | 9.93 | 8 | 386667 | 77 | 64111980 |
Altered state of consciousness | 14.53 | 9.93 | 151 | 386524 | 37751 | 64074306 |
Skin toxicity | 14.50 | 9.93 | 11 | 386664 | 6591 | 64105466 |
Neuroleptic malignant syndrome | 14.49 | 9.93 | 89 | 386586 | 24907 | 64087150 |
Treatment noncompliance | 14.40 | 9.93 | 179 | 386496 | 43303 | 64068754 |
Respiratory disorder | 14.37 | 9.93 | 300 | 386375 | 35811 | 64076246 |
Fungal rhinitis | 14.36 | 9.93 | 7 | 386668 | 51 | 64112006 |
Lupus vulgaris | 14.28 | 9.93 | 8 | 386667 | 80 | 64111977 |
Chest pain | 14.26 | 9.93 | 1219 | 385456 | 234761 | 63877296 |
Ejection fraction decreased | 14.25 | 9.93 | 107 | 386568 | 28600 | 64083457 |
Blood lactic acid increased | 14.24 | 9.93 | 109 | 386566 | 10292 | 64101765 |
Abnormal loss of weight | 14.22 | 9.93 | 14 | 386661 | 7386 | 64104671 |
Skin ulcer | 14.20 | 9.93 | 182 | 386493 | 43792 | 64068265 |
Injection site extravasation | 14.17 | 9.93 | 90 | 386585 | 7996 | 64104061 |
Carotid artery stenosis | 14.16 | 9.93 | 16 | 386659 | 7925 | 64104132 |
Disturbance in social behaviour | 14.15 | 9.93 | 3 | 386672 | 3884 | 64108173 |
Pyrexia | 14.13 | 9.93 | 3660 | 383015 | 554984 | 63557073 |
Skin lesion | 14.12 | 9.93 | 145 | 386530 | 36337 | 64075720 |
Visual impairment | 14.11 | 9.93 | 337 | 386338 | 73740 | 64038317 |
Tendonitis | 14.08 | 9.93 | 68 | 386607 | 20214 | 64091843 |
Incorrect drug administration rate | 14.05 | 9.93 | 42 | 386633 | 2677 | 64109380 |
Venoocclusive liver disease | 14.04 | 9.93 | 24 | 386651 | 9991 | 64102066 |
Dyslipidaemia | 14.03 | 9.93 | 21 | 386654 | 9221 | 64102836 |
Rebound effect | 13.93 | 9.93 | 6 | 386669 | 4911 | 64107146 |
Post-traumatic stress disorder | 13.91 | 9.93 | 56 | 386619 | 4149 | 64107908 |
Urinary casts | 13.89 | 9.93 | 24 | 386651 | 1058 | 64110999 |
Metastases to lung | 13.87 | 9.93 | 46 | 386629 | 15218 | 64096839 |
Bronchopulmonary aspergillosis | 13.83 | 9.93 | 63 | 386612 | 19022 | 64093035 |
Hepatitis B reactivation | 13.79 | 9.93 | 6 | 386669 | 4883 | 64107174 |
Dependent personality disorder | 13.74 | 9.93 | 9 | 386666 | 122 | 64111935 |
Obstructive airways disorder | 13.73 | 9.93 | 82 | 386593 | 23103 | 64088954 |
Infection | 13.72 | 9.93 | 1287 | 385388 | 183593 | 63928464 |
Macular oedema | 13.69 | 9.93 | 6 | 386669 | 4861 | 64107196 |
Poisoning deliberate | 13.67 | 9.93 | 132 | 386543 | 13326 | 64098731 |
Rhinitis allergic | 13.63 | 9.93 | 17 | 386658 | 8061 | 64103996 |
Specific gravity urine increased | 13.54 | 9.93 | 15 | 386660 | 431 | 64111626 |
Pulmonary embolism | 13.54 | 9.93 | 728 | 385947 | 145628 | 63966429 |
Hemiparesis | 13.50 | 9.93 | 114 | 386561 | 29713 | 64082344 |
Left ventricular dysfunction | 13.49 | 9.93 | 54 | 386621 | 16900 | 64095157 |
Erysipelas | 13.44 | 9.93 | 21 | 386654 | 9060 | 64102997 |
Nasal necrosis | 13.31 | 9.93 | 9 | 386666 | 129 | 64111928 |
Mitral valve incompetence | 13.25 | 9.93 | 94 | 386581 | 25444 | 64086613 |
Gynaecomastia | 13.24 | 9.93 | 10 | 386665 | 6006 | 64106051 |
Injection site discolouration | 13.22 | 9.93 | 13 | 386662 | 6862 | 64105195 |
Skin necrosis | 13.15 | 9.93 | 43 | 386632 | 14286 | 64097771 |
Rash | 13.13 | 9.93 | 3021 | 383654 | 455528 | 63656529 |
Ischaemic cardiomyopathy | 13.07 | 9.93 | 13 | 386662 | 6825 | 64105232 |
Bladder cancer | 13.04 | 9.93 | 29 | 386646 | 10945 | 64101112 |
Shock haemorrhagic | 13.04 | 9.93 | 54 | 386621 | 16737 | 64095320 |
Decerebrate posture | 13.00 | 9.93 | 10 | 386665 | 177 | 64111880 |
Traumatic liver injury | 12.87 | 9.93 | 16 | 386659 | 521 | 64111536 |
Carpal tunnel syndrome | 12.86 | 9.93 | 50 | 386625 | 15778 | 64096279 |
Dysphonia | 12.84 | 9.93 | 198 | 386477 | 46184 | 64065873 |
Graft versus host disease in gastrointestinal tract | 12.78 | 9.93 | 9 | 386666 | 5603 | 64106454 |
Alpha 1 microglobulin increased | 12.75 | 9.93 | 7 | 386668 | 67 | 64111990 |
Blood glucose increased | 12.73 | 9.93 | 470 | 386205 | 97603 | 64014454 |
Partial seizures | 12.73 | 9.93 | 15 | 386660 | 7292 | 64104765 |
Therapeutic response decreased | 12.73 | 9.93 | 228 | 386447 | 51960 | 64060097 |
Ischaemic stroke | 12.69 | 9.93 | 112 | 386563 | 28923 | 64083134 |
Acute coronary syndrome | 12.68 | 9.93 | 66 | 386609 | 19244 | 64092813 |
Gestational diabetes | 12.68 | 9.93 | 9 | 386666 | 5581 | 64106476 |
Dysgeusia | 12.63 | 9.93 | 202 | 386473 | 46845 | 64065212 |
Rash maculo-papular | 12.59 | 9.93 | 202 | 386473 | 46824 | 64065233 |
Derailment | 12.58 | 9.93 | 7 | 386668 | 69 | 64111988 |
Immunodeficiency | 12.58 | 9.93 | 150 | 386525 | 15974 | 64096083 |
Obesity | 12.56 | 9.93 | 72 | 386603 | 20490 | 64091567 |
Infusion site urticaria | 12.54 | 9.93 | 17 | 386658 | 604 | 64111453 |
Ventricular tachycardia | 12.53 | 9.93 | 138 | 386537 | 34127 | 64077930 |
Hypoglycaemic coma | 12.45 | 9.93 | 5 | 386670 | 4269 | 64107788 |
Paradoxical drug reaction | 12.44 | 9.93 | 11 | 386664 | 6109 | 64105948 |
Monocyte count increased | 12.39 | 9.93 | 87 | 386588 | 7992 | 64104065 |
Genital haemorrhage | 12.38 | 9.93 | 9 | 386666 | 5513 | 64106544 |
Lupus-like syndrome | 12.38 | 9.93 | 21 | 386654 | 8770 | 64103287 |
Sudden cardiac death | 12.37 | 9.93 | 6 | 386669 | 4581 | 64107476 |
Frequent bowel movements | 12.34 | 9.93 | 62 | 386613 | 18243 | 64093814 |
Drug abuser | 12.34 | 9.93 | 68 | 386607 | 5740 | 64106317 |
Renal disorder | 12.32 | 9.93 | 144 | 386531 | 35221 | 64076836 |
Brain stem glioma | 12.31 | 9.93 | 9 | 386666 | 147 | 64111910 |
Urobilinogen urine increased | 12.31 | 9.93 | 17 | 386658 | 615 | 64111442 |
Eyelid ptosis | 12.30 | 9.93 | 24 | 386651 | 9501 | 64102556 |
Accidental poisoning | 12.26 | 9.93 | 27 | 386648 | 1426 | 64110631 |
Kidney transplant rejection | 12.25 | 9.93 | 24 | 386651 | 9487 | 64102570 |
Blood uric acid decreased | 12.24 | 9.93 | 23 | 386652 | 1083 | 64110974 |
Dysarthria | 12.24 | 9.93 | 267 | 386408 | 59139 | 64052918 |
Transferrin decreased | 12.18 | 9.93 | 12 | 386663 | 300 | 64111757 |
Ascites | 12.11 | 9.93 | 281 | 386394 | 61720 | 64050337 |
Cerebral ischaemia | 12.10 | 9.93 | 26 | 386649 | 9936 | 64102121 |
Nocturia | 12.08 | 9.93 | 31 | 386644 | 11134 | 64100923 |
Disorientation | 12.06 | 9.93 | 249 | 386426 | 55579 | 64056478 |
Blood bilirubin increased | 12.02 | 9.93 | 440 | 386235 | 57113 | 64054944 |
Acute graft versus host disease in skin | 12.02 | 9.93 | 14 | 386661 | 6841 | 64105216 |
Blood bicarbonate decreased | 11.96 | 9.93 | 59 | 386616 | 4770 | 64107287 |
Metastases to central nervous system | 11.92 | 9.93 | 43 | 386632 | 13869 | 64098188 |
Musculoskeletal stiffness | 11.90 | 9.93 | 875 | 385800 | 122331 | 63989726 |
Encephalopathy | 11.88 | 9.93 | 448 | 386227 | 58371 | 64053686 |
Pneumonia viral | 11.86 | 9.93 | 84 | 386591 | 7738 | 64104319 |
Pancreatic carcinoma | 11.85 | 9.93 | 28 | 386647 | 10345 | 64101712 |
Adrenergic syndrome | 11.81 | 9.93 | 8 | 386667 | 115 | 64111942 |
Metastases to bone | 11.72 | 9.93 | 73 | 386602 | 20362 | 64091695 |
Urine ketone body present | 11.71 | 9.93 | 45 | 386630 | 3262 | 64108795 |
Electrolyte imbalance | 11.64 | 9.93 | 96 | 386579 | 25147 | 64086910 |
Aplasia pure red cell | 11.59 | 9.93 | 15 | 386660 | 6999 | 64105058 |
Stevens-Johnson syndrome | 11.57 | 9.93 | 278 | 386397 | 33971 | 64078086 |
Base excess | 11.55 | 9.93 | 7 | 386668 | 82 | 64111975 |
Anticipatory anxiety | 11.53 | 9.93 | 11 | 386664 | 264 | 64111793 |
Nephrogenic systemic fibrosis | 11.49 | 9.93 | 11 | 386664 | 5881 | 64106176 |
Sensitivity to weather change | 11.47 | 9.93 | 14 | 386661 | 6700 | 64105357 |
Balance disorder | 11.42 | 9.93 | 614 | 386061 | 83312 | 64028745 |
Leukoencephalopathy | 11.41 | 9.93 | 15 | 386660 | 6952 | 64105105 |
JC virus infection | 11.41 | 9.93 | 3 | 386672 | 3352 | 64108705 |
Angiokeratoma | 11.38 | 9.93 | 10 | 386665 | 215 | 64111842 |
Respiratory failure | 11.38 | 9.93 | 822 | 385853 | 160361 | 63951696 |
Vitamin K deficiency | 11.37 | 9.93 | 17 | 386658 | 662 | 64111395 |
Low density lipoprotein increased | 11.36 | 9.93 | 18 | 386657 | 7722 | 64104335 |
Pulmonary alveolar haemorrhage | 11.35 | 9.93 | 26 | 386649 | 9712 | 64102345 |
Hypokalaemia | 11.34 | 9.93 | 606 | 386069 | 121297 | 63990760 |
Stent placement | 11.34 | 9.93 | 10 | 386665 | 5561 | 64106496 |
Laboratory test abnormal | 11.34 | 9.93 | 91 | 386584 | 23972 | 64088085 |
Mydriasis | 11.32 | 9.93 | 141 | 386534 | 15171 | 64096886 |
Bone pain | 11.24 | 9.93 | 209 | 386466 | 47363 | 64064694 |
Human herpesvirus 6 infection | 11.22 | 9.93 | 7 | 386668 | 4647 | 64107410 |
Cystitis haemorrhagic | 11.21 | 9.93 | 19 | 386656 | 7937 | 64104120 |
Red cell distribution width decreased | 11.20 | 9.93 | 22 | 386653 | 1071 | 64110986 |
Activated partial thromboplastin time prolonged | 11.19 | 9.93 | 122 | 386553 | 12709 | 64099348 |
Urine oxalate increased | 11.19 | 9.93 | 10 | 386665 | 220 | 64111837 |
Infusion site discomfort | 11.18 | 9.93 | 18 | 386657 | 748 | 64111309 |
Cardiovascular disorder | 11.16 | 9.93 | 53 | 386622 | 15828 | 64096229 |
Swollen tongue | 11.16 | 9.93 | 145 | 386530 | 34809 | 64077248 |
Therapy non-responder | 11.16 | 9.93 | 305 | 386370 | 65594 | 64046463 |
Diaphragmatic rupture | 11.16 | 9.93 | 10 | 386665 | 221 | 64111836 |
Gastrooesophageal reflux disease | 11.12 | 9.93 | 397 | 386278 | 82746 | 64029311 |
Tardive dyskinesia | 11.11 | 9.93 | 24 | 386651 | 9154 | 64102903 |
BK virus infection | 11.10 | 9.93 | 17 | 386658 | 7395 | 64104662 |
Vertigo | 11.09 | 9.93 | 269 | 386406 | 58742 | 64053315 |
Retinal deposits | 11.08 | 9.93 | 8 | 386667 | 128 | 64111929 |
Eosinophilia | 11.07 | 9.93 | 161 | 386514 | 37915 | 64074142 |
Retinal haemorrhage | 11.05 | 9.93 | 17 | 386658 | 7381 | 64104676 |
Autonomic dysreflexia | 11.03 | 9.93 | 13 | 386662 | 400 | 64111657 |
Adenocarcinoma of colon | 11.01 | 9.93 | 8 | 386667 | 4900 | 64107157 |
Coagulation factor X level decreased | 11.00 | 9.93 | 7 | 386668 | 90 | 64111967 |
Skin burning sensation | 10.98 | 9.93 | 30 | 386645 | 10553 | 64101504 |
Dyskinesia | 10.95 | 9.93 | 168 | 386507 | 39220 | 64072837 |
Diplopia | 10.94 | 9.93 | 105 | 386570 | 26660 | 64085397 |
Aortic valve stenosis | 10.89 | 9.93 | 7 | 386668 | 4573 | 64107484 |
Medication overuse headache | 10.80 | 9.93 | 17 | 386658 | 693 | 64111364 |
Drug eruption | 10.78 | 9.93 | 152 | 386523 | 35984 | 64076073 |
Injection site nodule | 10.77 | 9.93 | 3 | 386672 | 3227 | 64108830 |
Vessel puncture site bruise | 10.76 | 9.93 | 13 | 386662 | 411 | 64111646 |
Respiratory tract congestion | 10.76 | 9.93 | 55 | 386620 | 16110 | 64095947 |
Eczema | 10.75 | 9.93 | 120 | 386555 | 29600 | 64082457 |
Blood creatine increased | 10.74 | 9.93 | 85 | 386590 | 8107 | 64103950 |
Acid-base balance disorder mixed | 10.74 | 9.93 | 7 | 386668 | 94 | 64111963 |
Endocardial fibrosis | 10.71 | 9.93 | 6 | 386669 | 60 | 64111997 |
Tricuspid valve incompetence | 10.68 | 9.93 | 59 | 386616 | 16944 | 64095113 |
Hernia | 10.65 | 9.93 | 126 | 386549 | 13392 | 64098665 |
Post procedural pulmonary embolism | 10.65 | 9.93 | 10 | 386665 | 235 | 64111822 |
Anal fissure | 10.62 | 9.93 | 58 | 386617 | 4878 | 64107179 |
Hypersensitivity vasculitis | 10.62 | 9.93 | 15 | 386660 | 6746 | 64105311 |
Blood loss anaemia | 10.58 | 9.93 | 45 | 386630 | 13847 | 64098210 |
Pleural effusion | 10.53 | 9.93 | 636 | 386039 | 125923 | 63986134 |
Impaired quality of life | 10.53 | 9.93 | 14 | 386661 | 6457 | 64105600 |
Hallucination, auditory | 10.52 | 9.93 | 59 | 386616 | 16880 | 64095177 |
pH urine increased | 10.52 | 9.93 | 13 | 386662 | 421 | 64111636 |
Mania | 10.51 | 9.93 | 56 | 386619 | 16230 | 64095827 |
Toxic skin eruption | 10.49 | 9.93 | 70 | 386605 | 19214 | 64092843 |
Dermatitis exfoliative generalised | 10.46 | 9.93 | 12 | 386663 | 5904 | 64106153 |
Gallbladder injury | 10.45 | 9.93 | 22 | 386653 | 1126 | 64110931 |
Myelocyte percentage increased | 10.44 | 9.93 | 10 | 386665 | 241 | 64111816 |
Oral pruritus | 10.41 | 9.93 | 29 | 386646 | 1776 | 64110281 |
Graft versus host disease in skin | 10.41 | 9.93 | 10 | 386665 | 5337 | 64106720 |
Atrioventricular block | 10.38 | 9.93 | 37 | 386638 | 11978 | 64100079 |
Drug use disorder | 10.37 | 9.93 | 67 | 386608 | 5987 | 64106070 |
Diffuse large B-cell lymphoma recurrent | 10.35 | 9.93 | 3 | 386672 | 3143 | 64108914 |
Hepatic cancer | 10.30 | 9.93 | 18 | 386657 | 7430 | 64104627 |
Vital capacity decreased | 10.29 | 9.93 | 21 | 386654 | 1051 | 64111006 |
Dermatitis acneiform | 10.29 | 9.93 | 22 | 386653 | 8421 | 64103636 |
Pulmonary fibrosis | 10.27 | 9.93 | 122 | 386553 | 29756 | 64082301 |
Spinal operation | 10.25 | 9.93 | 13 | 386662 | 6120 | 64105937 |
Oral discomfort | 10.16 | 9.93 | 22 | 386653 | 8384 | 64103673 |
Red blood cell elliptocytes present | 10.11 | 9.93 | 8 | 386667 | 148 | 64111909 |
Gastritis erosive | 10.10 | 9.93 | 27 | 386648 | 9568 | 64102489 |
Polydipsia | 10.09 | 9.93 | 12 | 386663 | 5809 | 64106248 |
Laryngospasm | 10.09 | 9.93 | 4 | 386671 | 3441 | 64108616 |
Leukocytosis | 10.07 | 9.93 | 297 | 386378 | 37443 | 64074614 |
Cystic fibrosis | 10.03 | 9.93 | 4 | 386671 | 3430 | 64108627 |
Dermatitis | 10.03 | 9.93 | 65 | 386610 | 17964 | 64094093 |
Dystonia | 10.00 | 9.93 | 69 | 386606 | 18796 | 64093261 |
Intestinal haemorrhage | 9.95 | 9.93 | 11 | 386664 | 5503 | 64106554 |
Dysstasia | 9.95 | 9.93 | 90 | 386585 | 23125 | 64088932 |
Deep vein thrombosis postoperative | 9.94 | 9.93 | 24 | 386651 | 1347 | 64110710 |
None
Source | Code | Description |
---|---|---|
ATC | D11AX26 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
ATC | N06BC01 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Xanthine derivatives |
ATC | V04CG30 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for gastric secretion |
FDA CS | M0023046 | Xanthines |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D000697 | Central Nervous System Stimulants |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D058914 | Purinergic Antagonists |
MeSH PA | D058915 | Purinergic P1 Receptor Antagonists |
FDA PE | N0000175729 | Central Nervous System Stimulation |
FDA EPC | N0000175739 | Central Nervous System Stimulant |
FDA EPC | N0000175790 | Methylxanthine |
CHEBI has role | CHEBI:25435 | mutagens |
CHEBI has role | CHEBI:35337 | analeptic |
CHEBI has role | CHEBI:35471 | psychotropic drugs |
CHEBI has role | CHEBI:35498 | diuretics |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50218 | phosphodiesterase inhibitors |
CHEBI has role | CHEBI:50925 | serine/threonine protein kinase inhibitor |
CHEBI has role | CHEBI:53121 | adenosine A2A receptor antagonists |
CHEBI has role | CHEBI:60809 | adjuvants |
CHEBI has role | CHEBI:64047 | food additives |
CHEBI has role | CHEBI:67114 | ryanodine receptor activators |
CHEBI has role | CHEBI:71232 | adenosine receptor antagonists |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:76924 | plant metabolites |
CHEBI has role | CHEBI:76946 | fungal metabolites |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:85234 | human blood serum metabolites |
CHEBI has role | CHEBI:176497 | geroprotectors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Sinus headache | indication | 4969004 | |
Apnea in the newborn | indication | 13094009 | |
Pain | indication | 22253000 | |
Migraine | indication | 37796009 | DOID:6364 |
Joint pain | indication | 57676002 | |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Common cold | indication | 82272006 | DOID:10459 |
Vascular headache | indication | 128187005 | |
Backache | indication | 161891005 | |
Cluster headache syndrome | indication | 193031009 | |
Spasticity | indication | 221360009 | |
Headache disorder | indication | 230461009 | |
Dysmenorrhea | indication | 266599000 | |
Influenza-like symptoms | indication | 315642008 | |
Tension-type headache | indication | 398057008 | |
Cluster Headache Prevention | indication | ||
Fatigue | off-label use | 84229001 | |
Urinary incontinence | off-label use | 165232002 | |
Obesity | off-label use | 414916001 | DOID:9970 |
Brain damage | contraindication | 2470005 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Hypophosphatemia | contraindication | 4996001 | |
Tachyarrhythmia | contraindication | 6285003 | |
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Hyperammonemia | contraindication | 9360008 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Asthenia | contraindication | 13791008 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Hyperkalemia | contraindication | 14140009 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Chronic disease of respiratory system | contraindication | 17097001 | |
Mood swings | contraindication | 18963009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Ventricular tachycardia | contraindication | 25569003 | |
Alcohol intoxication | contraindication | 25702006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Atony of colon | contraindication | 29479008 | |
Hypercapnia | contraindication | 29596007 | |
Dehydration | contraindication | 34095006 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Depressive disorder | contraindication | 35489007 | |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Hypokalemia | contraindication | 43339004 | |
Body fluid retention | contraindication | 43498006 | |
Hyperactive behavior | contraindication | 44548000 | |
Fecal impaction | contraindication | 44635007 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Retroperitoneal fibrosis | contraindication | 49120005 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Acidosis | contraindication | 51387008 | |
Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
Gastrointestinal perforation | contraindication | 51875005 | |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Nasal polyp | contraindication | 52756005 | |
Gastrectomy | contraindication | 53442002 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Peptic reflux disease | contraindication | 57643001 | |
Congenital myotonia, autosomal dominant form | contraindication | 57938005 | |
Acute nephropathy | contraindication | 58574008 | |
Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
Hepatic failure | contraindication | 59927004 | |
Diarrhea | contraindication | 62315008 | |
Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Arterial thrombosis | contraindication | 65198009 | |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Hypermagnesemia | contraindication | 66978005 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Hemorrhoids | contraindication | 70153002 | DOID:9746 |
Poisoning by acetaminophen | contraindication | 70273001 | |
Agoraphobia | contraindication | 70691001 | DOID:593 |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Factor II deficiency | contraindication | 73975000 | |
Reye's syndrome | contraindication | 74351001 | DOID:14525 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Urethral stricture | contraindication | 76618002 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Pulmonary emphysema | contraindication | 87433001 | |
Gout | contraindication | 90560007 | DOID:13189 |
Chronic renal failure syndrome | contraindication | 90688005 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Hemophilia | contraindication | 90935002 | |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Obstruction of duodenum | contraindication | 95532008 | DOID:3558 |
Disorder of biliary tract | contraindication | 105997008 | DOID:9741 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Prolonged QT interval | contraindication | 111975006 | |
Acute abdominal pain | contraindication | 116290004 | |
Procedure on urinary system | contraindication | 118677009 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
von Willebrand disorder | contraindication | 128105004 | DOID:12531 |
Seizure disorder | contraindication | 128613002 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Prolonged PR interval | contraindication | 164947007 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
Insomnia | contraindication | 193462001 | |
Partial atrioventricular block | contraindication | 195039008 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Coronary artery bypass graft | contraindication | 232717009 | |
Myocardial dysfunction | contraindication | 233928007 | |
Peripheral ischemia | contraindication | 233958001 | |
Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
Gastroparesis | contraindication | 235675006 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Chronic diarrhea | contraindication | 236071009 | |
Hyporeninemic hypoaldosteronism | contraindication | 236464008 | |
Aluminum intoxication | contraindication | 236546003 | |
Bladder outflow obstruction | contraindication | 236645006 | |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Sepsis syndrome | contraindication | 238150007 | |
Pyloric obstruction | contraindication | 244815007 | |
Sleep automatism | contraindication | 247962006 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Drowsy | contraindication | 271782001 | |
Exacerbation of asthma | contraindication | 281239006 | |
Cerebral ischemia | contraindication | 287731003 | |
Pregnancy, function | contraindication | 289908002 | |
Lesion of brain | contraindication | 301766008 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Familial hyperkalemic periodic paralysis | contraindication | 304737009 | DOID:14451 |
Panic disorder | contraindication | 371631005 | DOID:594 |
Coma | contraindication | 371632003 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Cardiovascular event risk | contraindication | 395112001 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Peripheral vascular disease | contraindication | 400047006 | |
Respiratory insufficiency | contraindication | 409623005 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 | |
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
Fibrosis of pleura | contraindication | 442110002 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Hypertensive urgency | contraindication | 443482000 | |
Acute erosive gastritis | contraindication | 444926003 | |
Smokes tobacco daily | contraindication | 449868002 | |
Severe dehydration | contraindication | 450316000 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
Ergot Alkaloid Toxicity | contraindication | ||
Acute Thromboembolic Stroke | contraindication | ||
Organic Cardiac Disease | contraindication | ||
Severe Pruritus | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 1.86 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Adenosine receptor A1 | GPCR | ANTAGONIST | Ki | 4.97 | IUPHAR | CHEMBL | |||
Adenosine receptor A2b | GPCR | ANTAGONIST | Ki | 4.77 | WOMBAT-PK | CHEMBL | |||
Adenosine receptor A2a | GPCR | ANTAGONIST | Ki | 5.61 | CHEMBL | CHEMBL | |||
Acetylcholinesterase | Enzyme | IC50 | 5.14 | CHEMBL | |||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Kinase | IC50 | 4.12 | CHEMBL | |||||
Guanine deaminase | Enzyme | Ki | 4.99 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.31 | CHEMBL | |||||
Adenosine receptor A3 | GPCR | ANTAGONIST | Ki | 4.33 | WOMBAT-PK | ||||
Glycogen phosphorylase, muscle form | Enzyme | IC50 | 4.13 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 4.77 | CHEMBL | |||||
Adenosine receptor A2a | GPCR | Ki | 5.03 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 4.54 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 4 | CHEMBL | |||||
Adenosine A2 receptor | GPCR | Ki | 4.57 | CHEMBL | |||||
Adenosine receptor | GPCR | Ki | 4.22 | CHEMBL | |||||
Adenosine A2a receptor | GPCR | Ki | 4.10 | CHEMBL | |||||
Adenosine receptor A2b | GPCR | ANTAGONIST | Ki | 4.89 | IUPHAR |
ID | Source |
---|---|
4017537 | VUID |
N0000145919 | NUI |
D00528 | KEGG_DRUG |
69-22-7 | SECONDARY_CAS_RN |
1886 | RXNORM |
C0006644 | UMLSCUI |
CHEBI:27732 | CHEBI |
CFF | PDB_CHEM_ID |
CHEMBL113 | ChEMBL_ID |
DB00201 | DRUGBANK_ID |
CHEMBL1200569 | ChEMBL_ID |
D002110 | MESH_DESCRIPTOR_UI |
2519 | PUBCHEM_CID |
C026189 | MESH_SUPPLEMENTAL_RECORD_UI |
407 | IUPHAR_LIGAND_ID |
3G6A5W338E | UNII |
11623 | MMSL |
17093 | MMSL |
4318 | MMSL |
4319 | MMSL |
46084 | MMSL |
4939 | MMSL |
d00801 | MMSL |
000600 | NDDF |
000601 | NDDF |
23068001 | SNOMEDCT_US |
255641001 | SNOMEDCT_US |
91107009 | SNOMEDCT_US |
4017537 | VANDF |
4018995 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Fiorinal with Codeine | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0023-6010 | CAPSULE | 40 mg | ORAL | NDA | 36 sections |
Fiorinal | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0023-6146 | CAPSULE | 40 mg | ORAL | NDA | 23 sections |
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0054-0650 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0054-3000 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-2000 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 13 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-2001 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
ExcedrinExtra Strength Geltabs | HUMAN OTC DRUG LABEL | 3 | 0067-2021 | TABLET, COATED | 65 mg | ORAL | OTC monograph not final | 14 sections |
ExcedrinMigraine Geltabs | HUMAN OTC DRUG LABEL | 3 | 0067-2035 | TABLET, COATED | 65 mg | ORAL | NDA | 14 sections |
EXCEDRINMIGRAINE | HUMAN OTC DRUG LABEL | 3 | 0067-2039 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 15 sections |
ExcedrinMigraine | HUMAN OTC DRUG LABEL | 3 | 0067-2040 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 16 sections |
ExcedrinTension Headache | HUMAN OTC DRUG LABEL | 2 | 0067-8139 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
EXCEDRINMIGRAINE | HUMAN OTC DRUG LABEL | 3 | 0067-8201 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 15 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-8202 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-8203 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
good sense migraine formula | HUMAN OTC DRUG LABEL | 3 | 0113-0374 | TABLET, FILM COATED | 65 mg | ORAL | ANDA | 15 sections |
good sense stay awake | HUMAN OTC DRUG LABEL | 1 | 0113-0409 | TABLET | 200 mg | ORAL | OTC monograph final | 14 sections |
good sense headache relief | HUMAN OTC DRUG LABEL | 3 | 0113-1855 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
basic care migraine relief | HUMAN OTC DRUG LABEL | 3 | 0113-7374 | TABLET, FILM COATED | 65 mg | ORAL | ANDA | 15 sections |
PANADOLExtra | HUMAN OTC DRUG LABEL | 2 | 0135-0620 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 16 sections |
Butalbital, Acetaminophen, and Caffeine | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0143-0170 | CAPSULE | 40 mg | ORAL | ANDA | 26 sections |
ERGOTAMINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-2120 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 22 sections |
Bayer Headache | HUMAN OTC DRUG LABEL | 2 | 0280-0064 | TABLET | 32.50 mg | ORAL | OTC monograph not final | 14 sections |
Alka-Seltzer Hangover Relief | HUMAN OTC DRUG LABEL | 2 | 0280-0084 | TABLET, EFFERVESCENT | 65 mg | ORAL | OTC monograph not final | 17 sections |
Alka-Seltzer Hangover Relief | HUMAN OTC DRUG LABEL | 2 | 0280-0084 | TABLET, EFFERVESCENT | 65 mg | ORAL | OTC monograph not final | 17 sections |
Bayer Back and BodyExtra Strength | HUMAN OTC DRUG LABEL | 2 | 0280-2150 | TABLET | 35.50 mg | ORAL | OTC monograph not final | 15 sections |
Midol Complete | HUMAN OTC DRUG LABEL | 3 | 0280-8005 | TABLET | 60 mg | ORAL | OTC monograph not final | 17 sections |
Midol CompleteGelcaps | HUMAN OTC DRUG LABEL | 3 | 0280-8015 | TABLET, COATED | 60 mg | ORAL | OTC monograph not final | 16 sections |
Extra Strength Headache Relief | HUMAN OTC DRUG LABEL | 3 | 0363-0021 | CAPSULE | 65 mg | ORAL | OTC monograph not final | 16 sections |
Headache ReliefExtra Strength | HUMAN OTC DRUG LABEL | 3 | 0363-0159 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
Stay AwakeMaximum Strength | HUMAN OTC DRUG LABEL | 1 | 0363-0226 | TABLET | 200 mg | ORAL | OTC monograph final | 13 sections |