magnesium chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4200 7786-30-3

Description:

MoleculeDescription

Synonyms:

  • magnesium chloride
Magnesium chloride. An inorganic compound consisting of one magnesium and two chloride ions. The compound is used in medicine as a source of magnesium ions, which are essential for many cellular activities. It has also been used as a cathartic and in alloys.
  • Molecular weight: 95.21
  • Formula: Cl2Mg
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2.50 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1975 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 700.20 18.73 441 5864 373940 63108777
Peritonitis bacterial 559.71 18.73 123 6182 4756 63477961
Peritonitis 376.37 18.73 116 6189 17038 63465679
Peritoneal dialysis complication 356.61 18.73 67 6238 1153 63481564
Toxic anterior segment syndrome 343.63 18.73 69 6236 1702 63481015
Fungal peritonitis 232.24 18.73 41 6264 488 63482229
Device interaction 171.94 18.73 28 6277 196 63482521
Sepsis 154.50 18.73 125 6180 152998 63329719
Endophthalmitis 135.21 18.73 37 6268 3555 63479162
Ultrafiltration failure 96.76 18.73 17 6288 196 63482521
Encapsulating peritoneal sclerosis 94.56 18.73 18 6287 332 63482385
Peritoneal cloudy effluent 68.81 18.73 12 6293 132 63482585
Hypervolaemia 66.35 18.73 39 6266 28374 63454343
Cardiac disorder 54.29 18.73 43 6262 50773 63431944
Cardiovascular disorder 52.70 18.73 25 6280 11787 63470930
Post procedural complication 52.27 18.73 28 6277 17046 63465671
Tonsillar haemorrhage 49.59 18.73 10 6295 251 63482466
Myocardial infarction 49.28 18.73 55 6250 99838 63382879
Cardiac arrest 49.21 18.73 53 6252 92492 63390225
Anterior chamber inflammation 47.34 18.73 10 6295 317 63482400
Drug ineffective 43.67 18.73 25 6280 1044740 62437977
Bloody peritoneal effluent 41.93 18.73 7 6298 58 63482659
Cardiac failure 40.43 18.73 47 6258 89095 63393622
Gangrene 40.25 18.73 17 6288 6106 63476611
Marasmus 37.42 18.73 9 6296 516 63482201
Cataract operation complication 36.57 18.73 7 6298 133 63482584
Cerebrovascular accident 34.76 18.73 48 6257 107976 63374741
Hypoglycaemia 34.75 18.73 36 6269 60029 63422688
Anterior chamber disorder 30.91 18.73 6 6299 123 63482594
Diabetic complication 27.94 18.73 8 6297 905 63481812
Hypoglycaemic coma 26.93 18.73 10 6295 2565 63480152
Pulmonary oedema 26.67 18.73 30 6275 54843 63427874
Noninfectious peritonitis 24.37 18.73 5 6300 137 63482580
Pneumonia 23.07 18.73 98 6207 456669 63026048
Abdominal distension 22.78 18.73 35 6270 86580 63396137
Hypotension 22.77 18.73 69 6236 272535 63210182
Dermatitis exfoliative 22.66 18.73 11 6294 5448 63477269
Joint swelling 22.46 18.73 3 6302 327663 63155054
Drug intolerance 20.74 18.73 3 6302 308658 63174059
Catheter site infection 20.70 18.73 10 6295 4904 63477813
Diabetic foot 20.35 18.73 7 6298 1440 63481277
Corneal oedema 20.14 18.73 7 6298 1486 63481231
Amylase abnormal 19.83 18.73 3 6302 12 63482705
Blood glucose false positive 19.83 18.73 3 6302 12 63482705
Faeces soft 19.30 18.73 10 6295 5682 63477035

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis bacterial 786.68 23.66 190 6307 5920 34944514
Death 749.83 23.66 599 5898 397450 34552984
Peritonitis 490.99 23.66 163 6334 16202 34934232
Peritoneal dialysis complication 470.53 23.66 99 6398 1610 34948824
Fungal peritonitis 325.98 23.66 64 6433 719 34949715
Toxic anterior segment syndrome 283.39 23.66 61 6436 1108 34949326
Device interaction 138.94 23.66 30 6467 552 34949882
Cardiac disorder 114.79 23.66 81 6416 43045 34907389
Myocardial infarction 114.38 23.66 126 6371 120959 34829475
Encapsulating peritoneal sclerosis 110.93 23.66 25 6472 564 34949870
Ultrafiltration failure 109.91 23.66 20 6477 143 34950291
Cardiac failure 94.93 23.66 100 6397 91148 34859286
Gangrene 92.27 23.66 34 6463 4552 34945882
Peritoneal cloudy effluent 83.41 23.66 16 6481 157 34950277
Hypervolaemia 81.90 23.66 49 6448 19660 34930774
Noninfectious peritonitis 81.17 23.66 15 6482 118 34950316
Cardiac arrest 80.37 23.66 94 6403 96065 34854369
Post procedural complication 76.86 23.66 39 6458 11349 34939085
Sepsis 74.16 23.66 120 6377 166441 34783993
Endophthalmitis 70.53 23.66 26 6471 3482 34946952
Cardiovascular disorder 58.00 23.66 31 6466 10025 34940409
Catheter site infection 55.00 23.66 20 6477 2577 34947857
Drug ineffective 51.84 23.66 11 6486 456740 34493694
Cataract operation complication 47.85 23.66 10 6487 156 34950278
Bloody peritoneal effluent 45.57 23.66 9 6488 104 34950330
Peritoneal effluent abnormal 38.35 23.66 7 6490 51 34950383
Hernia 32.62 23.66 21 6476 9562 34940872
Blood glucose false positive 32.37 23.66 6 6491 48 34950386
Cerebrovascular accident 32.16 23.66 57 6440 84754 34865680
Procedural pain 28.22 23.66 15 6482 4791 34945643
Localised infection 27.15 23.66 24 6473 17563 34932871
Peritoneal disorder 27.15 23.66 7 6490 282 34950152
Drug interaction 26.46 23.66 5 6492 225941 34724493
Keratitis 26.41 23.66 10 6487 1441 34948993
Complication associated with device 25.10 23.66 15 6482 5991 34944443
Toxicity to various agents 24.40 23.66 4 6493 200358 34750076
Procedural complication 24.12 23.66 13 6484 4270 34946164
Peritoneal effluent leukocyte count increased 23.93 23.66 4 6493 16 34950418
Hypoglycaemia 23.70 23.66 39 6458 54601 34895833

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis bacterial 1064.75 18.51 240 8630 9327 79726191
Toxic anterior segment syndrome 561.43 18.51 114 8756 2650 79732868
Peritonitis 554.91 18.51 180 8690 27856 79707662
Peritoneal dialysis complication 495.35 18.51 100 8770 2254 79733264
Death 447.05 18.51 420 8450 566094 79169424
Fungal peritonitis 336.98 18.51 64 8806 1036 79734482
Device interaction 244.58 18.51 46 8824 704 79734814
Endophthalmitis 197.86 18.51 58 8812 6370 79729148
Encapsulating peritoneal sclerosis 166.21 18.51 34 8836 817 79734701
Sepsis 108.02 18.51 141 8729 269287 79466231
Ultrafiltration failure 104.17 18.51 19 8851 243 79735275
Peritoneal cloudy effluent 99.28 18.51 19 8851 320 79735198
Cardiac arrest 94.99 18.51 106 8764 171990 79563528
Post procedural complication 93.80 18.51 48 8822 23781 79711737
Cataract operation complication 88.96 18.51 17 8853 284 79735234
Gangrene 87.06 18.51 34 8836 8930 79726588
Hypervolaemia 74.94 18.51 51 8819 42639 79692879
Noninfectious peritonitis 72.75 18.51 14 8856 243 79735275
Myocardial infarction 70.03 18.51 94 8776 184035 79551483
Cardiac disorder 63.41 18.51 55 8815 65702 79669816
Drug ineffective 58.09 18.51 24 8846 1080889 78654629
Blood glucose false positive 57.16 18.51 9 8861 43 79735475
Bloody peritoneal effluent 52.16 18.51 10 8860 170 79735348
Catheter site infection 46.29 18.51 20 8850 6775 79728743
Cardiac failure 45.54 18.51 70 8800 154772 79580746
Complication associated with device 40.80 18.51 25 8845 17471 79718047
Hypoglycaemia 40.31 18.51 53 8817 101541 79633977
Peritoneal effluent abnormal 36.81 18.51 6 8864 37 79735481
Abdominal distension 36.45 18.51 55 8815 119595 79615923
Anterior chamber disorder 34.76 18.51 7 8863 155 79735363
Peritoneal disorder 33.40 18.51 9 8861 726 79734792
Diabetic complication 32.67 18.51 10 8860 1269 79734249
Procedural complication 31.16 18.51 16 8854 7967 79727551
Tonsillar haemorrhage 30.51 18.51 7 8863 291 79735227
Drug interaction 30.16 18.51 5 8865 415178 79320340
Toxicity to various agents 28.65 18.51 6 8864 421534 79313984
Regurgitation 28.58 18.51 11 8859 2776 79732742
Pneumonia 28.06 18.51 146 8724 660100 79075418
Rash pruritic 26.31 18.51 36 8834 71593 79663925
Hypoglycaemic coma 25.99 18.51 12 8858 4748 79730770
Rash erythematous 25.84 18.51 32 8838 57737 79677781
Keratitis 23.92 18.51 11 8859 4311 79731207
Blood loss anaemia 23.64 18.51 17 8853 15481 79720037
Lactobacillus test positive 23.52 18.51 4 8866 33 79735485
Multimorbidity 23.46 18.51 8 8862 1431 79734087
Haemodialysis 23.40 18.51 18 8852 18150 79717368
Corneal disorder 23.34 18.51 9 8861 2282 79733236
Cerebrovascular accident 22.65 18.51 52 8818 155240 79580278
Staphylococcal infection 22.47 18.51 30 8840 58265 79677253
Corneal oedema 22.17 18.51 9 8861 2611 79732907
Device related infection 22.16 18.51 23 8847 34271 79701247
Amylase abnormal 21.87 18.51 4 8866 52 79735466
Peritoneal fluid analysis abnormal 21.59 18.51 4 8866 56 79735462
Ileus 21.45 18.51 20 8850 26191 79709327
Failure to thrive 20.41 18.51 14 8856 11830 79723688
Hypotension 19.79 18.51 99 8771 440218 79295300
Dermatitis exfoliative 19.14 18.51 13 8857 10816 79724702
Product complaint 18.91 18.51 14 8856 13335 79722183
Intraocular pressure increased 18.57 18.51 12 8858 9193 79726325

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A12CC01 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Magnesium
ATC B05XA11 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypomagnesemia indication 190855004
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Classical phenylketonuria contraindication 7573000
Poisoning by digitalis glycoside contraindication 12876009
Hyperkalemia contraindication 14140009
Complete atrioventricular block contraindication 27885002
Sarcoidosis contraindication 31541009 DOID:11335
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Heart disease contraindication 56265001 DOID:114
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hypercalcemia contraindication 66931009 DOID:12678
Hypermagnesemia contraindication 66978005
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Oliguria contraindication 83128009
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Hyporeninemic hypoaldosteronism contraindication 236464008
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.21GM/100ML;2.8GM/100ML;9.07GM/100ML NORMOCARB HF 25 DIALYSIS SUPS N021910 July 26, 2006 RX SOLUTION INJECTION 7300674 March 4, 2023 USE AS REPLACEMENT SOLUTION, HEMOFILTRATION SOLUTION OR HEMODIAFILTRATION SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018213 VUID
N0000146546 NUI
D04834 KEGG_DRUG
4018213 VANDF
C0024472 UMLSCUI
CHEBI:86345 CHEBI
CHEMBL2219642 ChEMBL_ID
CHEMBL3185229 ChEMBL_ID
D015636 MESH_DESCRIPTOR_UI
DB09407 DRUGBANK_ID
02F3473H9O UNII
6579 RXNORM
5007 MMSL
5009 MMSL
71973 MMSL
d03796 MMSL
000786 NDDF
45733002 SNOMEDCT_US
768454005 SNOMEDCT_US
7791-18-6 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-1795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-1795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
HyperlyteCR HUMAN PRESCRIPTION DRUG LABEL 5 0264-1943 INJECTION, SOLUTION, CONCENTRATE 0.51 g INTRAVENOUS UNAPPROVED DRUG OTHER 18 sections
HyperlyteCR HUMAN PRESCRIPTION DRUG LABEL 5 0264-1943 INJECTION, SOLUTION, CONCENTRATE 0.51 g INTRAVENOUS UNAPPROVED DRUG OTHER 18 sections
Balanced Salt HUMAN PRESCRIPTION DRUG LABEL 6 0264-1945 SOLUTION 0.30 mg IRRIGATION ANDA 11 sections
Physiolyte HUMAN PRESCRIPTION DRUG LABEL 5 0264-2205 IRRIGANT 0.03 g IRRIGATION NDA 20 sections
Physiolyte HUMAN PRESCRIPTION DRUG LABEL 5 0264-2205 IRRIGANT 0.03 g IRRIGATION NDA 20 sections
Physiolyte HUMAN PRESCRIPTION DRUG LABEL 5 0264-2205 IRRIGANT 0.03 g IRRIGATION NDA 20 sections
Physiolyte HUMAN PRESCRIPTION DRUG LABEL 5 0264-2205 IRRIGANT 0.03 g IRRIGATION NDA 20 sections
Balanced Salt HUMAN PRESCRIPTION DRUG LABEL 6 0264-2514 SOLUTION 0.30 mg IRRIGATION ANDA 11 sections
Isolyte S HUMAN PRESCRIPTION DRUG LABEL 5 0264-7703 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 19 sections
Isolyte S HUMAN PRESCRIPTION DRUG LABEL 5 0264-7703 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 19 sections
Isolyte S pH 7.4 HUMAN PRESCRIPTION DRUG LABEL 7 0264-7707 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 24 sections
Isolyte S pH 7.4 HUMAN PRESCRIPTION DRUG LABEL 7 0264-7707 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 24 sections
Isolyte S pH 7.4 HUMAN PRESCRIPTION DRUG LABEL 7 0264-7707 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 24 sections
Isolyte S pH 7.4 HUMAN PRESCRIPTION DRUG LABEL 7 0264-7707 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 24 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 31 mg INTRAVENOUS NDA 19 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 31 mg INTRAVENOUS NDA 19 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 31 mg INTRAVENOUS NDA 19 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 31 mg INTRAVENOUS NDA 19 sections
Plasma-Lyte 148 HUMAN PRESCRIPTION DRUG LABEL 5 0338-0179 INJECTION, SOLUTION 30 mg INTRAVENOUS NDA 20 sections
Plasma-Lyte 148 HUMAN PRESCRIPTION DRUG LABEL 5 0338-0179 INJECTION, SOLUTION 30 mg INTRAVENOUS NDA 20 sections