magnesium chloride Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4200 7786-30-3

Description:

MoleculeDescription

Synonyms:

  • magnesium chloride
Magnesium chloride. An inorganic compound consisting of one magnesium and two chloride ions. The compound is used in medicine as a source of magnesium ions, which are essential for many cellular activities. It has also been used as a cathartic and in alloys.
  • Molecular weight: 95.21
  • Formula: Cl2Mg
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2.50 g O
0.80 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1975 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 5538.65 19.52 2883 23047 354349 52968787
Peritonitis bacterial 4174.81 19.52 958 24972 8547 53314589
Peritonitis 3435.78 19.52 968 24962 20719 53302417
Peritoneal dialysis complication 1709.26 19.52 371 25559 2462 53320674
Fluid overload 1319.45 19.52 499 25431 27332 53295804
Toxic anterior segment syndrome 753.03 19.52 184 25746 2164 53320972
Fungal peritonitis 580.71 19.52 125 25805 789 53322347
Sepsis 506.75 19.52 478 25452 145951 53177185
Ultrafiltration failure 497.63 19.52 104 25826 557 53322579
Bloody peritoneal effluent 461.43 19.52 93 25837 402 53322734
Myocardial infarction 327.29 19.52 316 25614 99038 53224098
Endophthalmitis 319.07 19.52 103 25827 3484 53319652
Abdominal distension 309.46 19.52 278 25652 79512 53243624
Cardiovascular disorder 284.72 19.52 133 25797 12280 53310856
Hypotension 281.31 19.52 468 25462 253608 53069528
Drug ineffective 272.55 19.52 38 25892 817207 52505929
Acute myocardial infarction 270.62 19.52 180 25750 33055 53290081
Catheter site infection 263.37 19.52 97 25833 4895 53318241
Procedural pain 263.19 19.52 133 25797 14584 53308552
Cardiac arrest 253.57 19.52 268 25662 93399 53229737
Cardiac disorder 248.84 19.52 196 25734 46770 53276366
Cardio-respiratory arrest 240.18 19.52 211 25719 58547 53264589
Peritoneal cloudy effluent 236.56 19.52 49 25881 249 53322887
Cerebrovascular accident 226.40 19.52 267 25663 104907 53218229
Diabetic foot 223.33 19.52 66 25864 1652 53321484
Hypopyon 175.37 19.52 48 25882 903 53322233
Disease complication 174.56 19.52 64 25866 3186 53319950
Corneal oedema 166.77 19.52 54 25876 1843 53321293
Cardiac failure 146.31 19.52 194 25736 85650 53237486
Multimorbidity 143.99 19.52 39 25891 704 53322432
Device interaction 141.18 19.52 31 25899 217 53322919
Hypervolaemia 136.29 19.52 48 25882 2125 53321011
Rheumatoid arthritis 124.70 19.52 7 25923 314524 53008612
Fatigue 119.71 19.52 108 25822 730398 52592738
Cardiac failure congestive 118.83 19.52 183 25747 92574 53230562
Encapsulating peritoneal sclerosis 115.58 19.52 29 25901 382 53322754
Dehydration 114.92 19.52 253 25677 168157 53154979
Gangrene 107.92 19.52 51 25879 4826 53318310
Diabetic complication 107.82 19.52 33 25897 933 53322203
Headache 107.73 19.52 64 25866 536757 52786379
Anterior chamber fibrin 106.82 19.52 24 25906 189 53322947
Hernia 104.39 19.52 64 25866 10196 53312940
Umbilical hernia 103.40 19.52 42 25888 2760 53320376
Noninfectious peritonitis 103.18 19.52 24 25906 224 53322912
Arthralgia 102.36 19.52 43 25887 439740 52883396
Inadequate aseptic technique in use of product 100.37 19.52 21 25909 113 53323023
Abdominal pain 98.15 19.52 310 25620 255593 53067543
Treatment noncompliance 93.65 19.52 97 25833 32938 53290198
Malnutrition 91.73 19.52 68 25862 14803 53308333
Drug interaction 86.51 19.52 5 25925 219324 53103812
Fluid imbalance 84.61 19.52 23 25907 421 53322715
Device related infection 79.61 19.52 75 25855 22711 53300425
Fluid retention 76.26 19.52 112 25818 54289 53268847
Pleuroperitoneal communication 74.56 19.52 15 25915 64 53323072
Joint swelling 73.01 19.52 13 25917 234625 53088511
Alopecia 72.99 19.52 13 25917 234570 53088566
Drug intolerance 71.85 19.52 8 25922 205485 53117651
Post procedural complication 70.31 19.52 61 25869 16605 53306531
Peritoneal effluent abnormal 69.54 19.52 14 25916 60 53323076
Pulmonary oedema 65.96 19.52 104 25826 53619 53269517
Toxicity to various agents 64.46 19.52 14 25916 219584 53103552
Anterior chamber cell 63.96 19.52 20 25910 608 53322528
Extremity necrosis 63.94 19.52 26 25904 1713 53321423
Marasmus 62.22 19.52 19 25911 533 53322603
Device occlusion 60.77 19.52 39 25891 6726 53316410
Infusion related reaction 60.13 19.52 4 25926 155953 53167183
Abdominal hernia 58.54 19.52 34 25896 4906 53318230
Anterior chamber inflammation 56.92 19.52 16 25914 333 53322803
Anterior chamber disorder 56.72 19.52 13 25917 113 53323023
Off label use 56.59 19.52 89 25841 472123 52851013
Azotaemia 55.98 19.52 32 25898 4481 53318655
Pneumoperitoneum 51.94 19.52 22 25908 1607 53321529
Calciphylaxis 51.42 19.52 26 25904 2849 53320287
Pneumonia 50.24 19.52 354 25576 406815 52916321
Completed suicide 49.26 19.52 5 25925 138196 53184940
Arthropathy 48.20 19.52 6 25924 141447 53181689
Treatment failure 47.49 19.52 4 25926 128399 53194737
Pain 47.12 19.52 139 25791 588259 52734877
Peritoneal disorder 45.60 19.52 15 25915 538 53322598
Hepatic enzyme increased 43.86 19.52 5 25925 126190 53196946
Aqueous fibrin 43.22 19.52 10 25920 91 53323045
Product use issue 42.81 19.52 8 25922 139576 53183560
Hypoglycaemia 41.67 19.52 90 25840 58923 53264213
Injection site pain 40.67 19.52 4 25926 113387 53209749
Wrong product administered 40.33 19.52 29 25901 6019 53317117
General physical health deterioration 39.82 19.52 159 25771 146783 53176353
Bacterial translocation 39.74 19.52 11 25919 216 53322920
Intestinal perforation 38.87 19.52 37 25893 11343 53311793
Maternal exposure during pregnancy 38.10 19.52 14 25916 155625 53167511
Dizziness 37.51 19.52 78 25852 372181 52950955
Procedural complication 37.09 19.52 26 25904 5186 53317950
Hypophagia 36.55 19.52 59 25871 31003 53292133
Acute kidney injury 36.26 19.52 42 25888 253826 53069310
Myalgia 36.24 19.52 10 25920 133481 53189655
Localised infection 35.98 19.52 54 25876 26662 53296474
Sinusitis 35.24 19.52 19 25911 168545 53154591
Anterior chamber flare 34.66 19.52 9 25921 137 53322999
Tonsillar haemorrhage 34.63 19.52 10 25920 230 53322906
Failure to thrive 34.46 19.52 28 25902 6964 53316172
Nasopharyngitis 34.29 19.52 26 25904 192269 53130867
Cataract operation complication 34.24 19.52 9 25921 144 53322992
Vitritis 33.96 19.52 14 25916 955 53322181
Somnolence 33.50 19.52 20 25910 167714 53155422
Hypersensitivity 33.27 19.52 32 25898 210633 53112503
Gait disturbance 33.06 19.52 18 25912 158824 53164312
Fibrin 32.67 19.52 7 25923 43 53323093
Insomnia 32.46 19.52 26 25904 187046 53136090
Paraesthesia 32.01 19.52 11 25919 127504 53195632
Pain in extremity 31.95 19.52 56 25874 284994 53038142
Eye inflammation 31.44 19.52 22 25908 4375 53318761
Product container issue 30.41 19.52 16 25914 1903 53321233
Infection 30.14 19.52 164 25766 172041 53151095
Depression 29.85 19.52 27 25903 183025 53140111
Overdose 29.37 19.52 8 25922 107728 53215408
Anxiety 28.66 19.52 32 25898 196672 53126464
Neutropenia 27.76 19.52 22 25908 159163 53163973
Exposure during pregnancy 27.70 19.52 13 25917 124847 53198289
Multiple organ dysfunction syndrome 27.55 19.52 74 25856 55603 53267533
Critical illness 27.46 19.52 8 25922 190 53322946
Asthenia 27.41 19.52 271 25659 343319 52979817
Exfoliative rash 27.27 19.52 17 25913 2787 53320349
Erythema 26.99 19.52 22 25908 156947 53166189
Hypertensive crisis 26.56 19.52 34 25896 14472 53308664
Systemic lupus erythematosus 26.40 19.52 14 25916 125400 53197736
Nosocomial infection 26.21 19.52 14 25916 1717 53321419
Metabolic alkalosis 26.12 19.52 17 25913 3002 53320134
Condition aggravated 25.31 19.52 68 25862 297066 53026070
Septic shock 25.24 19.52 77 25853 62152 53260984
Pyrexia 24.99 19.52 106 25824 403087 52920049
Hypoaesthesia 24.98 19.52 17 25913 132978 53190158
Blood glucose decreased 24.90 19.52 39 25891 19977 53303159
Injection site erythema 24.61 19.52 4 25926 77245 53245891
Blood potassium decreased 24.43 19.52 58 25872 40402 53282734
Pancytopenia 24.32 19.52 7 25923 90921 53232215
Peritoneal effluent leukocyte count increased 24.20 19.52 5 25925 25 53323111
Haemorrhagic stroke 24.13 19.52 21 25909 5737 53317399
Cough 24.05 19.52 56 25874 256837 53066299
Foreign body in eye 23.76 19.52 7 25923 173 53322963
Hydrothorax 23.47 19.52 10 25920 741 53322395
Post procedural infection 23.38 19.52 24 25906 8057 53315079
White blood cell count decreased 23.26 19.52 16 25914 124459 53198677
Febrile neutropenia 23.16 19.52 11 25919 104925 53218211
Intestinal ischaemia 23.01 19.52 23 25907 7479 53315657
Psoriasis 22.76 19.52 7 25923 87082 53236054
Mental status changes postoperative 22.54 19.52 7 25923 208 53322928
Intentional overdose 22.52 19.52 3 25927 67202 53255934
Therapy cessation 22.42 19.52 45 25885 27980 53295156
Staphylococcus test positive 22.30 19.52 17 25913 3856 53319280
Complication associated with device 22.23 19.52 33 25897 16132 53307004
Cardiac procedure complication 22.22 19.52 7 25923 218 53322918
Palpitations 22.18 19.52 11 25919 102337 53220799
Blood pressure decreased 21.85 19.52 73 25857 61796 53261340
Flushing 21.74 19.52 4 25926 70596 53252540
Osteoarthritis 21.69 19.52 4 25926 70482 53252654
Catheter site abscess 21.46 19.52 5 25925 47 53323089
Confusion postoperative 21.44 19.52 7 25923 245 53322891
Device leakage 21.20 19.52 20 25910 6060 53317076
Hip fracture 20.98 19.52 44 25886 28213 53294923
Renal transplant failure 20.80 19.52 9 25921 693 53322443
Escherichia peritonitis 20.09 19.52 4 25926 16 53323120
Blood glucose false positive 20.09 19.52 4 25926 16 53323120
Mental status changes 19.98 19.52 53 25877 39518 53283618
Oncologic complication 19.90 19.52 6 25924 161 53322975
Hospitalisation 19.87 19.52 5 25925 71007 53252129
Post procedural inflammation 19.78 19.52 5 25925 68 53323068
Catheter site extravasation 19.59 19.52 7 25923 323 53322813
Pancreatitis 19.56 19.52 58 25872 46084 53277052

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 5403.97 21.14 3697 27432 378820 32103577
Peritonitis bacterial 5195.49 21.14 1376 29753 11120 32471277
Peritonitis 3976.29 21.14 1273 29856 21057 32461340
Peritoneal dialysis complication 2338.44 21.14 587 30542 3681 32478716
Fluid overload 1664.52 21.14 646 30483 18975 32463422
Fungal peritonitis 773.14 21.14 195 30934 1241 32481156
Ultrafiltration failure 560.19 21.14 133 30996 630 32481767
Abdominal distension 462.86 21.14 387 30742 50908 32431489
Toxic anterior segment syndrome 448.17 21.14 130 30999 1482 32480915
Bloody peritoneal effluent 395.51 21.14 95 31034 477 32481920
Cardiac disorder 379.86 21.14 317 30812 41549 32440848
Catheter site infection 371.85 21.14 128 31001 2626 32479771
Myocardial infarction 371.41 21.14 525 30604 125151 32357246
Procedural pain 353.17 21.14 148 30981 5281 32477116
Sepsis 348.78 21.14 578 30551 158256 32324141
Cardiac arrest 321.42 21.14 428 30701 96348 32386049
Peritoneal cloudy effluent 307.17 21.14 74 31055 377 32482020
Cardiovascular disorder 259.66 21.14 149 30980 10613 32471784
Drug ineffective 256.45 21.14 33 31096 383444 32098953
Diabetic foot 242.70 21.14 95 31034 2831 32479566
Cardiac failure 237.07 21.14 360 30769 91313 32391084
Hernia 227.57 21.14 131 30998 9384 32473013
Multimorbidity 194.23 21.14 54 31075 521 32481876
Fluid retention 192.28 21.14 177 30952 26373 32456024
Cardio-respiratory arrest 189.18 21.14 250 30879 55739 32426658
Inguinal hernia 186.22 21.14 108 31021 7844 32474553
Acute kidney injury 178.29 21.14 33 31096 293435 32188962
Acute myocardial infarction 178.28 21.14 241 30888 54908 32427489
Endophthalmitis 174.18 21.14 82 31047 3867 32478530
Noninfectious peritonitis 155.28 21.14 38 31091 209 32482188
Hypotension 151.26 21.14 502 30627 215608 32266789
Hypervolaemia 146.97 21.14 64 31065 2510 32479887
Off label use 145.46 21.14 56 31073 306264 32176133
Drug interaction 144.93 21.14 19 31110 218166 32264231
Toxicity to various agents 144.82 21.14 6 31123 178035 32304362
Gangrene 140.70 21.14 76 31053 4806 32477591
Inadequate aseptic technique in use of product 140.24 21.14 33 31096 149 32482248
Diabetic complication 136.28 21.14 46 31083 886 32481511
Fluid imbalance 133.18 21.14 38 31091 406 32481991
Fatigue 128.25 21.14 90 31039 350611 32131786
Peritoneal disorder 125.81 21.14 36 31093 389 32482008
Device related infection 124.86 21.14 117 31012 17816 32464581
Umbilical hernia 124.52 21.14 67 31062 4203 32478194
Cerebrovascular accident 123.46 21.14 262 30867 86058 32396339
Azotaemia 117.94 21.14 70 31059 5304 32477093
Dehydration 115.63 21.14 327 30802 128631 32353766
Peritoneal effluent abnormal 113.15 21.14 27 31102 131 32482266
Disease complication 107.19 21.14 53 31076 2786 32479611
Encapsulating peritoneal sclerosis 105.08 21.14 35 31094 646 32481751
Localised infection 99.84 21.14 96 31033 15091 32467306
Device interaction 94.42 21.14 31 31098 546 32481851
Treatment noncompliance 92.59 21.14 122 31007 27080 32455317
Headache 87.89 21.14 39 31090 196158 32286239
Cardiac failure congestive 87.84 21.14 227 30902 84625 32397772
Post procedural complication 85.41 21.14 79 31050 11828 32470569
Neutropenia 74.24 21.14 22 31107 142153 32340244
Hypopyon 73.75 21.14 25 31104 488 32481909
Dizziness 71.02 21.14 58 31071 209560 32272837
Corneal oedema 70.06 21.14 32 31097 1406 32480991
Abdominal pain 69.27 21.14 305 30824 149224 32333173
Somnolence 66.54 21.14 10 31119 103787 32378610
Completed suicide 66.53 21.14 6 31123 92511 32389886
Drug abuse 64.19 21.14 3 31126 80240 32402157
Thrombocytopenia 62.50 21.14 32 31097 148267 32334130
Product use in unapproved indication 61.79 21.14 6 31123 87198 32395199
Platelet count decreased 61.15 21.14 17 31112 114574 32367823
Device occlusion 60.14 21.14 51 31078 6807 32475590
Arthralgia 59.68 21.14 34 31095 148414 32333983
Complication associated with device 59.17 21.14 48 31081 6024 32476373
Overdose 59.12 21.14 7 31122 87070 32395327
Febrile neutropenia 58.00 21.14 21 31108 119545 32362852
Pancytopenia 57.99 21.14 9 31120 91226 32391171
White blood cell count decreased 55.74 21.14 10 31119 91188 32391209
Anterior chamber fibrin 55.28 21.14 15 31114 131 32482266
Failure to thrive 54.82 21.14 53 31076 8382 32474015
Disease progression 54.24 21.14 9 31120 86853 32395544
Extremity necrosis 53.86 21.14 29 31100 1821 32480576
Anterior chamber cell 51.26 21.14 18 31111 392 32482005
Anxiety 49.82 21.14 15 31114 95990 32386407
Myalgia 47.33 21.14 10 31119 81220 32401177
Marasmus 46.90 21.14 19 31110 620 32481777
Cardiac procedure complication 46.79 21.14 15 31114 244 32482153
Infection 46.37 21.14 182 30947 84533 32397864
Swelling 45.56 21.14 108 31021 38114 32444283
Pulmonary oedema 44.98 21.14 121 31008 46146 32436251
Calciphylaxis 44.18 21.14 22 31107 1174 32481223
Abdominal discomfort 43.71 21.14 130 30999 52494 32429903
Hip fracture 43.10 21.14 55 31074 11820 32470577
Alanine aminotransferase increased 43.07 21.14 11 31118 78468 32403929
Postoperative wound infection 42.95 21.14 36 31093 4728 32477669
Nausea 42.52 21.14 161 30968 320688 32161709
Pyrexia 42.11 21.14 161 30968 319807 32162590
Renal impairment 40.00 21.14 19 31110 91953 32390444
Abdominal hernia 39.56 21.14 28 31101 2865 32479532
Foreign body in eye 39.03 21.14 11 31118 112 32482285
Pleuroperitoneal communication 38.18 21.14 9 31120 41 32482356
Rhabdomyolysis 37.74 21.14 9 31120 67256 32415141
Mycobacterial peritonitis 37.32 21.14 9 31120 46 32482351
Anaemia 35.93 21.14 103 31026 223521 32258876
Diarrhoea 35.92 21.14 204 30925 364598 32117799
Hydrothorax 35.90 21.14 15 31114 530 32481867
Leukopenia 35.85 21.14 7 31122 60115 32422282
Agitation 35.57 21.14 6 31123 57230 32425167
Depression 35.18 21.14 25 31104 97035 32385362
Aspartate aminotransferase increased 35.15 21.14 10 31119 66419 32415978
Insomnia 34.88 21.14 27 31102 100321 32382076
Neuropathy peripheral 34.88 21.14 15 31114 76967 32405430
Malignant neoplasm progression 34.46 21.14 16 31113 78480 32403917
Procedural complication 33.34 21.14 31 31098 4669 32477728
Psoriasis 33.12 21.14 3 31126 46120 32436277
Staphylococcus test positive 32.93 21.14 26 31103 3139 32479258
Malnutrition 32.42 21.14 49 31080 12329 32470068
Eye inflammation 32.06 21.14 21 31108 1892 32480505
Pneumonia 32.03 21.14 497 30632 354755 32127642
Erythema 32.01 21.14 20 31109 83085 32399312
Cataract operation complication 32.00 21.14 10 31119 149 32482248
Tachycardia 31.91 21.14 18 31111 79070 32403327
Rheumatoid arthritis 31.71 21.14 3 31126 44541 32437856
Neutrophil count decreased 31.47 21.14 4 31125 47135 32435262
Gait disturbance 31.45 21.14 19 31110 80389 32402008
Asthma 31.28 21.14 3 31126 44062 32438335
Discomfort 31.01 21.14 55 31074 15800 32466597
Inappropriate schedule of product administration 30.32 21.14 4 31125 45821 32436576
Peritoneal effluent leukocyte count increased 30.04 21.14 7 31122 30 32482367
Blood creatine phosphokinase increased 30.02 21.14 4 31125 45472 32436925
Pulmonary embolism 29.72 21.14 22 31107 83637 32398760
Interstitial lung disease 28.92 21.14 13 31116 64988 32417409
Diabetic vascular disorder 28.69 21.14 8 31121 78 32482319
Fibrin 28.68 21.14 7 31122 38 32482359
Peripheral vascular disorder 28.53 21.14 30 31099 5242 32477155
Blood creatinine increased 28.47 21.14 30 31099 96102 32386295
Corneal opacity 28.46 21.14 13 31116 571 32481826
Diabetic ulcer 28.45 21.14 9 31120 140 32482257
General physical health deterioration 28.23 21.14 198 30931 115061 32367336
Infusion related reaction 27.85 21.14 5 31124 45594 32436803
Cough 27.74 21.14 57 31072 138760 32343637
Aggression 27.14 21.14 3 31126 39386 32443011
Musculoskeletal stiffness 27.03 21.14 3 31126 39261 32443136
Hydrocele 26.93 21.14 20 31109 2204 32480193
Dyspnoea exertional 26.76 21.14 3 31126 38958 32443439
Product container issue 26.34 21.14 14 31115 856 32481541
Nosocomial infection 26.28 21.14 16 31113 1269 32481128
Bacterial translocation 26.22 21.14 10 31119 277 32482120
Drug intolerance 25.77 21.14 8 31121 50227 32432170
Chest pain 25.72 21.14 205 30924 123932 32358465
Road traffic accident 25.06 21.14 53 31076 17328 32465069
Vitritis 24.86 21.14 13 31116 769 32481628
Scrotal swelling 24.85 21.14 16 31113 1400 32480997
International normalised ratio increased 24.82 21.14 8 31121 49027 32433370
Corneal infiltrates 24.46 21.14 9 31120 225 32482172
Product use issue 24.36 21.14 10 31119 52767 32429630
Blood pressure abnormal 24.25 21.14 33 31096 7547 32474850
Hallucination 24.24 21.14 10 31119 52609 32429788
Foetal exposure during pregnancy 24.22 21.14 5 31124 41296 32441101
Blood glucose decreased 24.00 21.14 45 31084 13489 32468908
Post procedural infection 23.73 21.14 26 31103 4759 32477638
Hepatic function abnormal 23.26 21.14 7 31122 44833 32437564
Hospitalisation 23.05 21.14 9 31120 48962 32433435
Paraesthesia 22.95 21.14 14 31115 58930 32423467
Skin exfoliation 22.66 21.14 64 31065 25093 32457304
Blood glucose false positive 22.58 21.14 6 31123 48 32482349
Oxygen saturation decreased 22.38 21.14 9 31120 48090 32434307
Blood bilirubin increased 22.12 21.14 5 31124 38779 32443618
Pain 21.73 21.14 99 31030 187457 32294940
Intestinal perforation 21.65 21.14 34 31095 8841 32473556
Withdrawal of life support 21.54 21.14 5 31124 21 32482376
Anterior chamber disorder 21.49 21.14 7 31122 120 32482277
Coronary artery occlusion 21.38 21.14 39 31090 11446 32470951
Stomatitis 21.38 21.14 6 31123 40223 32442174
Tremor 21.24 21.14 28 31101 81249 32401148
Aqueous fibrin 21.21 21.14 6 31123 62 32482335
Intentional product use issue 21.16 21.14 7 31122 42204 32440193

Pharmacologic Action:

SourceCodeDescription
ATC A12CC01 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Magnesium
ATC B05XA11 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypomagnesemia indication 190855004
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Classical phenylketonuria contraindication 7573000
Poisoning by digitalis glycoside contraindication 12876009
Hyperkalemia contraindication 14140009
Complete atrioventricular block contraindication 27885002
Sarcoidosis contraindication 31541009 DOID:11335
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Heart disease contraindication 56265001 DOID:114
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hypercalcemia contraindication 66931009 DOID:12678
Hypermagnesemia contraindication 66978005
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Oliguria contraindication 83128009
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Hyporeninemic hypoaldosteronism contraindication 236464008
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.21GM/100ML;2.8GM/100ML;9.07GM/100ML NORMOCARB HF 25 DIALYSIS SUPS N021910 July 26, 2006 RX SOLUTION INJECTION 7300674 March 4, 2023 USE AS REPLACEMENT SOLUTION, HEMOFILTRATION SOLUTION OR HEMODIAFILTRATION SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3.68GM/1000ML;3.05GM/1000ML;0.314GM/1000ML ;3.09GM/1000ML;6.34GM/1000ML;0.187GM/1000ML (5000ML) PHOXILLUM BK 4/2.5 IN PLASTIC CONTAINER BAXTER HLTHCARE CORP N207026 Jan. 13, 2015 RX INJECTABLE INJECTION Jan. 13, 2022 AS A REPLACEMENT SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) AND IN CASE OF DRUG POISONING WHEN CRRT IS USED TO REMOVE DIALYZABLE SUBSTANCES
N/A/1000ML;3.05GM/1000ML;0.314GM/1000ML;2.21GM/1000ML;6.95GM/1000ML;0.187GM/1000ML (5000ML) PHOXILLUM B22K 4/0 IN PLASTIC CONTAINER BAXTER HLTHCARE CORP N207026 Jan. 13, 2015 RX INJECTABLE INJECTION Jan. 13, 2022 AS A REPLACEMENT SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) AND IN CASE OF DRUG POISONING WHEN CRRT IS USED TO REMOVE DIALYZABLE SUBSTANCES

Bioactivity Summary:

None

External reference:

IDSource
4018213 VUID
N0000146546 NUI
D04834 KEGG_DRUG
4018213 VANDF
C0024472 UMLSCUI
CHEBI:86345 CHEBI
CHEMBL2219642 ChEMBL_ID
CHEMBL3185229 ChEMBL_ID
D015636 MESH_DESCRIPTOR_UI
DB09407 DRUGBANK_ID
7791-18-6 SECONDARY_CAS_RN
02F3473H9O UNII
46835706 PUBCHEM_CID
6579 RXNORM
5007 MMSL
5009 MMSL
71973 MMSL
d03796 MMSL
000786 NDDF
45733002 SNOMEDCT_US
768454005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-1795 SOLUTION 0.30 mg OPHTHALMIC NDA 9 sections
HyperlyteCR HUMAN PRESCRIPTION DRUG LABEL 5 0264-1943 INJECTION, SOLUTION, CONCENTRATE 0.51 g INTRAVENOUS UNAPPROVED DRUG OTHER 18 sections
HyperlyteCR HUMAN PRESCRIPTION DRUG LABEL 5 0264-1943 INJECTION, SOLUTION, CONCENTRATE 0.51 g INTRAVENOUS UNAPPROVED DRUG OTHER 18 sections
Balanced Salt HUMAN PRESCRIPTION DRUG LABEL 6 0264-1945 SOLUTION 0.30 mg IRRIGATION ANDA 11 sections
Physiolyte HUMAN PRESCRIPTION DRUG LABEL 5 0264-2205 IRRIGANT 0.03 g IRRIGATION NDA 20 sections
Physiolyte HUMAN PRESCRIPTION DRUG LABEL 5 0264-2205 IRRIGANT 0.03 g IRRIGATION NDA 20 sections
Balanced Salt HUMAN PRESCRIPTION DRUG LABEL 6 0264-2514 SOLUTION 0.30 mg IRRIGATION ANDA 11 sections
Isolyte S HUMAN PRESCRIPTION DRUG LABEL 5 0264-7703 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 19 sections
Isolyte S HUMAN PRESCRIPTION DRUG LABEL 5 0264-7703 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 19 sections
Isolyte S pH 7.4 HUMAN PRESCRIPTION DRUG LABEL 7 0264-7707 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 24 sections
Isolyte S pH 7.4 HUMAN PRESCRIPTION DRUG LABEL 7 0264-7707 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 24 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 31 mg INTRAVENOUS NDA 19 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 31 mg INTRAVENOUS NDA 19 sections
Plasma-Lyte 148 HUMAN PRESCRIPTION DRUG LABEL 5 0338-0179 INJECTION, SOLUTION 30 mg INTRAVENOUS NDA 20 sections
Plasma-Lyte 148 HUMAN PRESCRIPTION DRUG LABEL 5 0338-0179 INJECTION, SOLUTION 30 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-0202 INJECTION 51 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-0202 INJECTION 51 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-0206 INJECTION 51 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-0206 INJECTION 51 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-0210 INJECTION 51 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-0210 INJECTION 51 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-0214 INJECTION 51 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-0214 INJECTION 51 mg INTRAVENOUS NDA 20 sections
Plasma-Lyte A HUMAN PRESCRIPTION DRUG LABEL 5 0338-0221 INJECTION, SOLUTION 30 mg INTRAVENOUS NDA 19 sections
Plasma-Lyte A HUMAN PRESCRIPTION DRUG LABEL 5 0338-0221 INJECTION, SOLUTION 30 mg INTRAVENOUS NDA 19 sections
Cardioplegic HUMAN PRESCRIPTION DRUG LABEL 4 0338-0341 SOLUTION 325.30 mg INTRA-ARTERIAL ANDA 15 sections