sodium bicarbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4205 144-55-8

Description:

MoleculeDescription

Synonyms:

  • sodium bicarbonate
  • sodium hydrogen carbonate
A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
  • Molecular weight: 84.01
  • Formula: CHNaO3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Oct. 28, 1981 FDA ALCON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 2969.72 9.41 2492 533113 51099 90041743
Pemphigus 1784.35 9.41 29 535576 326835 89766007
Synovitis 1525.77 9.41 110 535495 329642 89763200
Hand deformity 1519.29 9.41 52 535553 296310 89796532
Systemic lupus erythematosus 1403.78 9.41 228 535377 361668 89731174
Glossodynia 1348.47 9.41 160 535445 321619 89771223
Anti-cyclic citrullinated peptide antibody positive 1320.64 9.41 14 535591 236419 89856423
Drug intolerance 1272.21 9.41 527 535078 447064 89645778
Contraindicated product administered 1263.42 9.41 192 535413 319947 89772895
Wound 1218.07 9.41 172 535433 302808 89790034
Duodenal ulcer perforation 1079.98 9.41 55 535550 221233 89871609
Helicobacter infection 1074.43 9.41 67 535538 226783 89866059
Pericarditis 1021.21 9.41 182 535423 269969 89822873
Treatment failure 1016.71 9.41 270 535335 303658 89789184
Folliculitis 990.26 9.41 53 535552 204300 89888542
Hypomagnesaemia 986.07 9.41 1133 534472 34455 90058387
Rheumatoid factor positive 959.18 9.41 10 535595 171640 89921202
Muscle injury 949.87 9.41 19 535586 176635 89916207
Arthropathy 924.16 9.41 507 535098 365735 89727107
Hyponatraemia 863.00 9.41 2216 533389 131322 89961520
Hepatic enzyme increased 859.66 9.41 535 535070 360201 89732641
Acute kidney injury 849.69 9.41 3947 531658 316440 89776402
Rheumatic fever 825.10 9.41 16 535589 153105 89939737
Joint swelling 806.73 9.41 1077 534528 502223 89590619
Therapeutic product effect decreased 800.68 9.41 319 535286 277252 89815590
Irritable bowel syndrome 731.13 9.41 165 535440 207283 89885559
White blood cell count decreased 723.22 9.41 2403 533202 164706 89928136
Drug interaction 691.30 9.41 3349 532256 273104 89819738
Drug ineffective 672.25 9.41 5116 530489 1379182 88713660
Impaired healing 670.71 9.41 272 535333 233927 89858915
Type 2 diabetes mellitus 652.58 9.41 195 535410 203049 89889793
Alopecia 625.72 9.41 1238 534367 493833 89599009
Swelling 618.51 9.41 950 534655 418108 89674734
Drug hypersensitivity 611.47 9.41 1130 534475 462479 89630363
Sleep disorder due to general medical condition, insomnia type 609.19 9.41 38 535567 128656 89964186
Swollen joint count increased 601.62 9.41 11 535594 111195 89981647
C-reactive protein abnormal 584.60 9.41 44 535561 127385 89965457
Rheumatoid arthritis 583.55 9.41 773 534832 361841 89731001
Maternal exposure during pregnancy 554.84 9.41 792 534813 359271 89733571
Psoriatic arthropathy 538.95 9.41 342 535263 227993 89864849
Tubulointerstitial nephritis 535.61 9.41 704 534901 24639 90068203
Abdominal discomfort 526.96 9.41 1286 534319 476042 89616800
Discomfort 520.29 9.41 512 535093 273823 89819019
Hypersensitivity 506.58 9.41 1219 534386 453458 89639384
Blood cholesterol increased 487.56 9.41 314 535291 207698 89885144
Hypocalcaemia 486.93 9.41 888 534717 41480 90051362
Chronic kidney disease 476.33 9.41 970 534635 49221 90043621
Joint range of motion decreased 467.68 9.41 113 535492 135530 89957312
Ill-defined disorder 464.38 9.41 257 535348 184634 89908208
Stomatitis 463.14 9.41 565 535040 274133 89818709
Facet joint syndrome 451.22 9.41 34 535571 98355 89994487
Lip dry 448.83 9.41 40 535565 100915 89991927
Musculoskeletal stiffness 447.12 9.41 662 534943 295870 89796972
Bursitis 445.53 9.41 114 535491 131540 89961302
Injury 417.82 9.41 332 535273 197017 89895825
Breast cancer stage III 411.75 9.41 21 535584 84426 90008416
Neutrophil count decreased 410.15 9.41 1136 534469 70396 90022446
Infusion related reaction 408.22 9.41 1191 534414 415589 89677253
Blister 406.53 9.41 547 535058 254451 89838391
Product use issue 398.56 9.41 846 534759 329073 89763769
Hypokalaemia 397.25 9.41 1682 533923 129434 89963408
Fibromyalgia 396.75 9.41 380 535225 205889 89886953
Peripheral venous disease 365.74 9.41 36 535569 83885 90008957
Grip strength decreased 352.52 9.41 61 535544 92515 90000327
Deep vein thrombosis postoperative 326.01 9.41 24 535581 70785 90022057
Wound infection 322.11 9.41 113 535492 106289 89986553
Infective pulmonary exacerbation of cystic fibrosis 320.25 9.41 348 535257 9931 90082911
Hereditary angioedema 316.41 9.41 331 535274 9034 90083808
Hypercholesterolaemia 316.16 9.41 101 535504 100791 89992051
Liver injury 289.26 9.41 349 535256 170218 89922624
Subacute cutaneous lupus erythematosus 286.20 9.41 207 535398 3375 90089467
Osteoarthritis 283.31 9.41 449 535156 195281 89897561
General physical health deterioration 282.59 9.41 1110 534495 354005 89738837
Adjustment disorder with depressed mood 267.80 9.41 17 535588 56736 90036106
Autoimmune disorder 266.33 9.41 63 535542 76681 90016161
Constipation 258.81 9.41 2664 532941 277731 89815111
Hypotension 256.45 9.41 2996 532609 322401 89770441
Orthostatic hypotension 254.46 9.41 679 534926 41148 90051694
Prescribed overdose 253.41 9.41 130 535475 97495 89995347
Nausea 248.60 9.41 8436 527169 1101880 88990962
X-ray abnormal 247.69 9.41 4 535601 45420 90047422
Hepatic function abnormal 246.65 9.41 716 534889 45572 90047270
Inflammation 244.23 9.41 425 535180 178167 89914675
Dislocation of vertebra 243.89 9.41 24 535581 55944 90036898
Blood calcium decreased 241.10 9.41 544 535061 29638 90063204
Diarrhoea 239.25 9.41 7248 528357 931942 89160900
Lower respiratory tract infection 236.71 9.41 728 534877 249931 89842911
Night sweats 234.06 9.41 249 535356 128517 89964325
Vomiting 229.23 9.41 6187 529418 782106 89310736
Renal injury 228.06 9.41 292 535313 9951 90082891
Chest discomfort 226.38 9.41 1497 534108 136868 89955974
Creatinine renal clearance decreased 225.90 9.41 403 535202 18496 90074346
Gait inability 224.43 9.41 323 535282 146133 89946709
Live birth 221.26 9.41 95 535510 79012 90013830
Urinary tract infection 221.13 9.41 2769 532836 302863 89789979
Weight increased 219.23 9.41 1507 534098 416420 89676422
Pulmonary fibrosis 217.37 9.41 189 535416 107314 89985528
Chills 215.96 9.41 1428 534177 130553 89962289
Blepharospasm 214.47 9.41 35 535570 55410 90037432
Lower limb fracture 213.60 9.41 118 535487 84895 90007947
Infection 211.17 9.41 1264 534341 360830 89732012
Bone erosion 210.71 9.41 31 535574 52990 90039852
Obesity 210.31 9.41 188 535417 105319 89987523
Nasopharyngitis 209.57 9.41 1476 534129 405628 89687214
Intentional product use issue 206.14 9.41 628 534977 216264 89876578
Fall 205.79 9.41 3993 531612 477817 89615025
Balance disorder 201.20 9.41 1117 534488 95963 89996879
Road traffic accident 200.25 9.41 204 535401 107422 89985420
Sciatica 196.91 9.41 185 535420 101197 89991645
Musculoskeletal pain 196.83 9.41 451 535154 170800 89922042
Prescribed underdose 196.04 9.41 99 535506 74920 90017922
Retinitis 195.97 9.41 7 535598 38451 90054391
Gastrointestinal disorder 188.11 9.41 828 534777 255859 89836983
Sedation complication 186.93 9.41 349 535256 16595 90076247
Anaemia 185.43 9.41 3022 532583 349780 89743062
Cognitive disorder 184.83 9.41 857 534748 68550 90024292
Red blood cell sedimentation rate increased 183.62 9.41 132 535473 82463 90010379
Granulocyte count decreased 183.03 9.41 136 535469 2316 90090526
Dehydration 177.65 9.41 1844 533761 192603 89900239
Adverse event 172.08 9.41 267 535338 117151 89975691
Exposure during pregnancy 170.50 9.41 776 534829 237634 89855208
Hip arthroplasty 170.45 9.41 121 535484 76087 90016755
Sleep disorder 167.77 9.41 603 535002 197427 89895415
Off label use 167.15 9.41 5103 530502 1097149 88995693
Condition aggravated 164.75 9.41 2502 533103 593043 89499799
Wheezing 163.72 9.41 786 534819 237294 89855548
Onychomadesis 163.11 9.41 36 535569 45962 90046880
Lung disorder 161.72 9.41 408 535197 149475 89943367
Lip swelling 157.78 9.41 545 535060 38065 90054777
Therapy non-responder 157.09 9.41 360 535245 136344 89956498
Nail disorder 155.76 9.41 77 535528 58990 90033852
Sepsis 149.73 9.41 1674 533931 178140 89914702
Mobility decreased 148.86 9.41 870 534735 249864 89842978
Agranulocytosis 144.71 9.41 496 535109 34506 90058336
Abdominal pain 144.68 9.41 3206 532399 392515 89700327
Dyspnoea 144.21 9.41 6472 529133 874483 89218359
Gastrointestinal haemorrhage 143.70 9.41 970 534635 89278 90003564
Pain 142.83 9.41 4646 530959 991695 89101147
Breast cancer stage II 141.94 9.41 20 535585 35314 90057528
Drug tolerance decreased 139.41 9.41 14 535591 32116 90060726
Hyperpyrexia 139.34 9.41 156 535449 4605 90088237
Exostosis 139.01 9.41 70 535535 53064 90039778
Rash 137.88 9.41 3617 531988 792483 89300359
Coeliac disease 137.37 9.41 46 535559 44564 90048278
Arthralgia 136.18 9.41 3532 532073 774990 89317852
Peripheral swelling 135.51 9.41 1676 533929 411430 89681412
Back injury 135.21 9.41 53 535552 46569 90046273
Liver disorder 134.82 9.41 325 535280 120944 89971898
C-reactive protein increased 134.12 9.41 583 535022 180806 89912036
Platelet count decreased 132.76 9.41 1315 534290 135654 89957188
Syncope 132.66 9.41 1282 534323 131381 89961461
Lethargy 132.48 9.41 729 534876 62410 90030432
Metabolic alkalosis 129.97 9.41 131 535474 3418 90089424
Hypoaesthesia 129.51 9.41 1209 534396 313001 89779841
Hyperkalaemia 128.97 9.41 739 534866 64225 90028617
Knee arthroplasty 124.91 9.41 186 535419 82996 90009846
Therapeutic product effect incomplete 124.78 9.41 655 534950 193241 89899601
Cystic fibrosis 123.77 9.41 134 535471 3807 90089035
Pregnancy 121.92 9.41 112 535493 61935 90030907
Renal failure 120.83 9.41 1245 534360 129762 89963080
Product label confusion 120.64 9.41 3 535602 22847 90069995
Tremor 119.43 9.41 1408 534197 151765 89941077
Illness 117.59 9.41 859 534746 81110 90011732
Sedation 116.81 9.41 579 535026 47592 90045250
Tachypnoea 115.81 9.41 332 535273 20977 90071865
Product dose omission issue 115.49 9.41 2391 533214 289296 89803546
Oedema 110.50 9.41 711 534894 199584 89893258
Inappropriate antidiuretic hormone secretion 110.01 9.41 308 535297 19197 90073645
Depressed level of consciousness 109.18 9.41 771 534834 72013 90020829
End stage renal disease 107.91 9.41 187 535418 8384 90084458
Blood sodium decreased 106.13 9.41 382 535223 27231 90065611
Tetany 105.08 9.41 101 535504 2483 90090359
Hallucination 105.03 9.41 709 534896 65250 90027592
Temperature intolerance 103.04 9.41 223 535382 11807 90081035
Liver function test increased 102.79 9.41 217 535388 84638 90008204
Plasma cell myeloma 102.76 9.41 496 535109 40332 90052510
Cough 102.55 9.41 2881 532724 366081 89726761
Seizure 101.87 9.41 1363 534242 151266 89941576
Haematemesis 101.53 9.41 432 535173 33294 90059548
International normalised ratio increased 99.72 9.41 547 535058 46769 90046073
Pancreatitis acute 97.95 9.41 413 535192 31702 90061140
Urinary retention 96.78 9.41 461 535144 37283 90055559
Haemoglobin decreased 96.69 9.41 1418 534187 160538 89932304
Onychomycosis 96.63 9.41 50 535555 37326 90055516
Hypernatraemia 95.73 9.41 187 535418 9200 90083642
Pallor 93.27 9.41 425 535180 33740 90059102
Sinusitis 91.75 9.41 1450 534155 341638 89751204
Device expulsion 91.31 9.41 65 535540 40821 90052021
Vision blurred 90.49 9.41 1024 534581 109269 89983573
Laryngitis 90.14 9.41 100 535505 50653 90042189
Walking aid user 89.59 9.41 49 535556 35457 90057385
Rhabdomyolysis 89.56 9.41 564 535041 50692 90042150
Toxic epidermal necrolysis 89.07 9.41 405 535200 32123 90060719
Back pain 89.05 9.41 2480 533125 314695 89778147
Electrocardiogram QT prolonged 88.24 9.41 731 534874 71725 90021117
Gastric pH decreased 88.08 9.41 61 535544 925 90091917
Atrial fibrillation 87.44 9.41 1189 534416 132422 89960420
Maternal exposure timing unspecified 87.38 9.41 14 535591 22469 90070373
Cogwheel rigidity 87.07 9.41 83 535522 2019 90090823
Metabolic acidosis 86.57 9.41 595 535010 55081 90037761
Porphyria acute 85.96 9.41 5 535600 17970 90074872
Seronegative arthritis 84.44 9.41 6 535599 18228 90074614
Palpitations 82.34 9.41 1199 534406 135529 89957313
Agitation 82.27 9.41 678 534927 66420 90026422
COVID-19 81.50 9.41 1427 534178 167416 89925426
Neutropenic sepsis 81.23 9.41 264 535341 17866 90074976
Tachycardia 80.24 9.41 1344 534261 156329 89936513
Disorientation 79.32 9.41 489 535116 43625 90049217
Taste disorder 79.15 9.41 152 535453 61394 90031448
Urticaria 78.55 9.41 1337 534268 311397 89781445
Contusion 78.26 9.41 1030 534575 250186 89842656
Pulmonary embolism 77.91 9.41 1145 534460 129675 89963167
Myalgia 77.47 9.41 1460 534145 173665 89919177
Rheumatoid nodule 77.39 9.41 13 535592 20153 90072689
Dry mouth 76.29 9.41 707 534898 183352 89909490
Swollen tongue 75.57 9.41 498 535107 45458 90047384
Dizziness 75.53 9.41 4230 531375 585054 89507788
Foot deformity 75.25 9.41 149 535456 59502 90033340
Ventricular tachycardia 74.77 9.41 317 535288 24391 90068451
Liver function test abnormal 74.74 9.41 536 535069 50309 90042533
Swelling face 74.46 9.41 772 534833 80580 90012262
Cyanosis 72.95 9.41 267 535338 19188 90073654
Hypophosphataemia 72.70 9.41 223 535382 14631 90078211
Renal impairment 72.64 9.41 947 534658 104474 89988368
Joint stiffness 71.94 9.41 229 535376 77813 90015029
Tinnitus 71.44 9.41 468 535137 42634 90050208
Hypoparathyroidism 71.33 9.41 54 535551 947 90091895
Gastritis 70.82 9.41 456 535149 41297 90051545
Electrolyte imbalance 70.58 9.41 303 535302 23442 90069400
Finger deformity 69.99 9.41 55 535550 32842 90060000
Hepatic cirrhosis 69.12 9.41 171 535434 63082 90029760
Angioedema 68.84 9.41 635 534970 64241 90028601
Blood urea increased 68.44 9.41 358 535247 30055 90062787
Muscle rigidity 68.34 9.41 213 535392 14096 90078746
Hypoglycaemia 68.33 9.41 672 534933 69176 90023666
Gastric polyps 66.92 9.41 108 535497 4564 90088278
Parkinsonism 66.84 9.41 209 535396 13856 90078986
Abdominal distension 65.62 9.41 1111 534494 129490 89963352
Osmotic demyelination syndrome 64.58 9.41 52 535553 1002 90091840
Hypertension 64.40 9.41 2137 533468 455395 89637447
Disability 64.24 9.41 88 535517 40657 90052185
Pyrexia 63.76 9.41 4627 530978 655858 89436984
Adverse drug reaction 63.45 9.41 416 535189 116285 89976557
Paraesthesia oral 63.39 9.41 361 535244 31298 90061544
Macular degeneration 63.37 9.41 413 535192 37557 90055285
Upper gastrointestinal haemorrhage 62.85 9.41 286 535319 22690 90070152
Disturbance in attention 62.10 9.41 484 535121 46625 90046217
Hyperhidrosis 61.88 9.41 1141 534464 135164 89957678
Chronic obstructive pulmonary disease 60.79 9.41 686 534919 73143 90019699
Asthenia 60.13 9.41 3788 531817 529963 89562879
Feeling of despair 60.08 9.41 84 535521 3120 90089722
Palmoplantar keratoderma 59.97 9.41 88 535517 3419 90089423
Cardiospasm 59.70 9.41 87 535518 3359 90089483
Blood magnesium decreased 59.37 9.41 216 535389 15477 90077365
Sensitisation 59.11 9.41 96 535509 4079 90088763
Bradycardia 58.94 9.41 756 534849 83091 90009751
Therapeutic response decreased 58.88 9.41 301 535304 89428 90003414
Subcutaneous drug absorption impaired 58.51 9.41 6 535599 13539 90079303
Respiratory failure 58.27 9.41 1004 534601 117414 89975428
Pruritus genital 58.11 9.41 100 535505 4458 90088384
Colitis 58.10 9.41 651 534954 69291 90023551
Depersonalisation/derealisation disorder 57.50 9.41 59 535546 1573 90091269
Heart rate increased 57.28 9.41 962 534643 111940 89980902
Atrial tachycardia 57.08 9.41 116 535489 5874 90086968
Transient ischaemic attack 56.03 9.41 442 535163 42734 90050108
Hiatus hernia 56.02 9.41 297 535308 25064 90067778
Subarachnoid haemorrhage 55.18 9.41 231 535374 17673 90075169
General symptom 55.10 9.41 10 535595 14658 90078184
Injection site reaction 54.85 9.41 319 535286 91761 90001081
Ventricular fibrillation 54.58 9.41 195 535410 13849 90078993
Oesophagitis 54.30 9.41 224 535381 17025 90075817
Cytokine release syndrome 54.07 9.41 316 535289 27657 90065185
Blood alkaline phosphatase increased 53.77 9.41 476 535129 47603 90045239
Blood creatinine increased 53.70 9.41 870 534735 100516 89992326
Ovarian hyperstimulation syndrome 52.90 9.41 111 535494 5751 90087091
Feeling abnormal 52.74 9.41 1328 534277 165907 89926935
Atrioventricular block first degree 52.60 9.41 139 535466 8372 90084470
Circulatory collapse 52.53 9.41 288 535317 24616 90068226
Adverse reaction 52.26 9.41 59 535546 29653 90063189
Disorganised speech 52.17 9.41 60 535545 1825 90091017
Renal disorder 52.15 9.41 393 535212 37466 90055376
Flushing 52.08 9.41 773 534832 87718 90005124
Tension headache 51.97 9.41 128 535477 7381 90085461
Clostridium difficile infection 51.49 9.41 379 535226 35866 90056976
Acidosis 51.35 9.41 179 535426 12557 90080285
Stevens-Johnson syndrome 51.16 9.41 323 535282 29053 90063789
Impaired quality of life 51.09 9.41 271 535334 22873 90069969
Infusion site pain 50.54 9.41 241 535364 19497 90073345
Temperature regulation disorder 50.51 9.41 12 535593 14567 90078275
Tenosynovitis 50.45 9.41 12 535593 14555 90078287
Granulocytopenia 50.22 9.41 115 535490 6326 90086516
Alanine aminotransferase increased 50.07 9.41 980 534625 117358 89975484
Lupus-like syndrome 49.59 9.41 137 535468 48709 90044133
Neutrophil count increased 49.10 9.41 236 535369 19154 90073688
Acute respiratory failure 49.08 9.41 427 535178 42491 90050351
Immunodeficiency 48.72 9.41 115 535490 43119 90049723
Dysphagia 48.59 9.41 933 534672 111345 89981497
Flatulence 48.58 9.41 414 535191 40953 90051889
Burning sensation 48.42 9.41 581 535024 62871 90029971
Hallucinations, mixed 47.98 9.41 107 535498 5782 90087060
Ulcer haemorrhage 47.69 9.41 51 535554 26270 90066572
Insurance issue 47.69 9.41 158 535447 10800 90082042
Completed suicide 47.65 9.41 588 535017 144470 89948372
Derealisation 47.53 9.41 51 535554 1434 90091408
Full blood count decreased 47.17 9.41 319 535286 29370 90063472
Sleep terror 46.83 9.41 90 535515 4374 90088468
Initial insomnia 46.72 9.41 141 535464 9169 90083673
Malaise 46.67 9.41 4045 531560 581941 89510901
Muscle twitching 46.52 9.41 273 535332 23929 90068913
Muscle spasticity 46.50 9.41 86 535519 35236 90057606
H1N1 influenza 45.85 9.41 58 535547 1952 90090890
Hypoaesthesia oral 45.55 9.41 198 535407 15402 90077440
Somnolence 44.91 9.41 1583 534022 207501 89885341
Pustular psoriasis 44.83 9.41 27 535578 18529 90074313
Joint dislocation 44.55 9.41 126 535479 44456 90048386
Mouth ulceration 44.31 9.41 395 535210 39579 90053263
Pulmonary malformation 44.23 9.41 28 535577 362 90092480
Infusion site reaction 44.21 9.41 29 535576 19010 90073832
Bone marrow failure 44.12 9.41 334 535271 31887 90060955
Melaena 43.94 9.41 354 535251 34443 90058399
Blood pressure diastolic abnormal 43.88 9.41 32 535573 19849 90072993
Drug resistance 43.87 9.41 70 535535 30379 90062463
Pancytopenia 43.72 9.41 974 534631 119289 89973553
Product use in unapproved indication 43.67 9.41 1586 534019 334650 89758192
Mania 43.35 9.41 182 535423 13942 90078900
Product administration error 43.24 9.41 286 535319 26137 90066705
Osteoporosis 42.97 9.41 364 535241 96167 89996675
Blood pressure decreased 42.81 9.41 651 534954 74244 90018598
Carotid artery occlusion 42.73 9.41 107 535498 6235 90086607
Haemarthrosis 42.48 9.41 81 535524 3913 90088929
Nightmare 42.36 9.41 246 535359 21479 90071363
Ejection fraction 42.31 9.41 69 535536 2942 90089900
Haematuria 42.27 9.41 352 535253 34585 90058257
Blood pressure systolic abnormal 42.15 9.41 32 535573 19446 90073396
Hypervolaemia 41.77 9.41 334 535271 32423 90060419
Arthritis 41.42 9.41 717 534888 166598 89926244
Polycystic ovaries 40.86 9.41 98 535507 5556 90087286
Dementia 40.71 9.41 261 535344 23600 90069242
Oropharyngeal pain 40.65 9.41 929 534676 114258 89978584
Abdominal tenderness 40.19 9.41 134 535471 9190 90083652
Discoloured vomit 40.03 9.41 42 535563 1150 90091692
Influenza 39.88 9.41 1092 534513 138172 89954670
Cross sensitivity reaction 39.51 9.41 65 535540 2792 90090050
Drug tolerance 39.33 9.41 29 535576 17887 90074955
Epistaxis 39.12 9.41 714 534891 84411 90008431
Faeces discoloured 38.74 9.41 237 535368 21083 90071759
Joint destruction 38.70 9.41 15 535590 13272 90079570
Parosmia 38.28 9.41 110 535495 6959 90085883
Deep vein thrombosis 37.83 9.41 756 534849 90864 90001978
Mouth swelling 37.60 9.41 95 535510 5567 90087275
Urine output decreased 37.60 9.41 161 535444 12442 90080400
Burning mouth syndrome 37.48 9.41 30 535575 573 90092269
Hyperreflexia 37.42 9.41 105 535500 6552 90086290
Compartment syndrome 37.27 9.41 64 535541 2848 90089994
Torsade de pointes 37.17 9.41 183 535422 14999 90077843
Bicytopenia 37.10 9.41 74 535531 3697 90089145
Blood potassium decreased 36.85 9.41 438 535167 47289 90045553
Serotonin syndrome 36.80 9.41 364 535241 37523 90055319
Spondylitis 36.60 9.41 19 535586 14159 90078683
Eye injury 36.39 9.41 10 535595 11010 90081832
Epilepsy 36.13 9.41 311 535294 81895 90010947
Malignant mediastinal neoplasm 35.95 9.41 43 535562 1365 90091477
Blood pressure systolic increased 35.90 9.41 200 535405 58145 90034697
Erythema 35.69 9.41 1677 533928 227569 89865273
Immunisation 35.65 9.41 54 535551 2159 90090683
Abortion spontaneous 35.65 9.41 181 535424 53875 90038967
Loss of personal independence in daily activities 35.40 9.41 578 535027 135527 89957315
Torus fracture 35.05 9.41 18 535587 151 90092691
Eructation 34.79 9.41 142 535463 10740 90082102
Hyperglycaemia 34.74 9.41 457 535148 50513 90042329
Tongue oedema 34.65 9.41 90 535515 5364 90087478
Atrioventricular block complete 34.58 9.41 132 535473 9679 90083163
Polyuria 34.50 9.41 134 535471 9906 90082936
Pulmonary hypertension 34.50 9.41 394 535211 42129 90050713
Dysgeusia 34.47 9.41 468 535137 52092 90040750
Underdose 34.42 9.41 183 535422 53834 90039008
Muscle disorder 34.39 9.41 90 535515 5389 90087453
Jaundice 34.35 9.41 318 535287 32199 90060643
Acidosis hyperchloraemic 34.20 9.41 34 535571 872 90091970
Drooling 34.16 9.41 80 535525 4466 90088376
Pulmonary pain 34.16 9.41 86 535519 5028 90087814
Nephropathy 34.00 9.41 126 535479 9109 90083733
Overlap syndrome 33.96 9.41 5 535600 8543 90084299
Cardiac arrest 33.88 9.41 836 534769 104099 89988743
Pulseless electrical activity 33.84 9.41 123 535482 8809 90084033
Eosinophilic oesophagitis 33.78 9.41 33 535572 828 90092014
Gamma-glutamyltransferase increased 33.70 9.41 358 535247 37594 90055248
Feeling of body temperature change 33.64 9.41 91 535514 5558 90087284
Thrombocytopenia 33.59 9.41 1532 534073 207193 89885649
Product quality issue 33.58 9.41 303 535302 79022 90013820
Migraine 33.58 9.41 862 534743 189530 89903312
Tension 33.55 9.41 70 535535 3612 90089230
Ejection fraction abnormal 33.54 9.41 56 535549 2435 90090407
Throat tightness 33.53 9.41 293 535312 29191 90063651
Hypoxia 33.52 9.41 608 534997 71791 90021051
Loss of consciousness 33.20 9.41 1074 534531 139164 89953678
Malignant neoplasm progression 32.94 9.41 439 535166 106431 89986411
Device difficult to use 32.83 9.41 33 535572 17492 90075350
Vertigo 32.58 9.41 587 535018 69224 90023618
Faecaloma 32.47 9.41 135 535470 10296 90082546
Lymphocyte count decreased 32.25 9.41 333 535272 34717 90058125
Dry skin 32.22 9.41 714 534891 87359 90005483
Genital blister 32.19 9.41 17 535588 152 90092690
Skin discolouration 32.17 9.41 402 535203 43913 90048929
Poisoning deliberate 32.10 9.41 30 535575 16456 90076386
Abnormal loss of weight 32.06 9.41 101 535504 6722 90086120
Hypothyroidism 32.01 9.41 466 535139 52661 90040181
Cystic fibrosis respiratory infection suppression 31.80 9.41 22 535583 333 90092509
Oral candidiasis 31.75 9.41 335 535270 35120 90057722
Blood creatine phosphokinase increased 31.66 9.41 324 535281 33699 90059143
Facial pain 31.63 9.41 158 535447 13024 90079818
Drug dispensed to wrong patient 31.58 9.41 22 535583 337 90092505
Diplopia 31.44 9.41 283 535322 28431 90064411
Multiple drug therapy 31.34 9.41 102 535503 6907 90085935
Transaminases increased 31.26 9.41 347 535258 36845 90055997
Cholecystitis chronic 31.24 9.41 128 535477 9698 90083144
Prescription drug used without a prescription 30.98 9.41 63 535542 3192 90089650
Respiratory tract malformation 30.91 9.41 17 535588 166 90092676
Palatal oedema 30.41 9.41 28 535577 651 90092191
Amyloid arthropathy 29.96 9.41 43 535562 1637 90091205
Acute generalised exanthematous pustulosis 29.94 9.41 160 535445 13543 90079299
Hyponatraemic encephalopathy 29.87 9.41 20 535585 286 90092556
Normal newborn 29.77 9.41 58 535547 23304 90069538
Presyncope 29.65 9.41 303 535302 31502 90061340
Foetal death 29.52 9.41 48 535557 20675 90072167
Headache 29.48 9.41 5654 529951 857092 89235750
Rash macular 29.45 9.41 291 535314 29989 90062853
Aspartate aminotransferase increased 29.42 9.41 807 534798 102130 89990712
Infusion site extravasation 29.33 9.41 130 535475 10198 90082644
Long QT syndrome 29.21 9.41 70 535535 3967 90088875
Hepatic failure 29.10 9.41 361 535244 39367 90053475
Laryngeal oedema 28.87 9.41 98 535507 6783 90086059
Limb injury 28.82 9.41 299 535306 31209 90061633
Anosmia 28.76 9.41 125 535480 9723 90083119
Speech disorder 28.72 9.41 403 535202 45182 90047660
Hypophagia 28.72 9.41 332 535273 35605 90057237
Hypergammaglobulinaemia 28.58 9.41 26 535579 595 90092247
Hypertensive nephropathy 28.52 9.41 27 535578 651 90092191
Pneumonitis 28.44 9.41 392 535213 43778 90049064
Cardiac failure 28.42 9.41 848 534757 108648 89984194
Duodenal stenosis 28.26 9.41 26 535579 604 90092238
Neutropenia 28.24 9.41 1612 533993 223292 89869550
Dermatitis atopic 28.14 9.41 236 535369 23236 90069606
Chromaturia 28.04 9.41 202 535403 18985 90073857
Wound infection pseudomonas 27.94 9.41 46 535559 1977 90090865
Haemorrhage intracranial 27.84 9.41 169 535436 14993 90077849
Coagulopathy 27.83 9.41 234 535371 23055 90069787
Breast cancer stage I 27.81 9.41 11 535594 9613 90083229
Rhinovirus infection 27.78 9.41 88 535517 5875 90086967
Intestinal ischaemia 27.68 9.41 115 535490 8768 90084074
Blood bilirubin increased 27.67 9.41 385 535220 43085 90049757
Dilatation intrahepatic duct acquired 27.49 9.41 28 535577 740 90092102
Femoral hernia incarcerated 27.48 9.41 39 535566 1469 90091373
Head discomfort 27.46 9.41 178 535427 16155 90076687
Emotional disorder 27.43 9.41 167 535438 14830 90078012
Laryngeal discomfort 27.19 9.41 22 535583 427 90092415
Blood fibrinogen decreased 27.07 9.41 34 535571 1136 90091706
Hip fracture 27.07 9.41 307 535298 32770 90060072
Lymphatic fistula 26.95 9.41 38 535567 1423 90091419
Ear pain 26.85 9.41 215 535390 57487 90035355
Cerebellar syndrome 26.80 9.41 66 535539 3806 90089036
Enthesopathy 26.76 9.41 11 535594 9393 90083449
Feeling cold 26.74 9.41 264 535341 27201 90065641
Arrhythmia 26.57 9.41 374 535231 41958 90050884
Unresponsive to stimuli 26.48 9.41 343 535262 37778 90055064
Hypochloraemia 26.45 9.41 52 535553 2570 90090272
Blood pressure fluctuation 26.42 9.41 191 535414 52222 90040620
Vascular device infection 26.42 9.41 140 535465 11812 90081030
Nephritis allergic 26.20 9.41 19 535586 311 90092531
Septic shock 26.13 9.41 667 534938 83493 90009349
Congenital thrombocytopenia 26.12 9.41 11 535594 55 90092787
Incontinence 26.11 9.41 152 535453 13283 90079559
Hallucination, visual 26.01 9.41 229 535376 22863 90069979
Pharyngeal swelling 25.88 9.41 122 535483 9822 90083020
Hyperchloraemia 25.82 9.41 29 535576 859 90091983
Hypertonia 25.80 9.41 78 535527 5077 90087765
Ventilation perfusion mismatch 25.72 9.41 24 535581 568 90092274
Urinary incontinence 25.67 9.41 337 535268 37229 90055613
Rash papular 25.66 9.41 207 535398 20148 90072694
Febrile neutropenia 25.63 9.41 1163 534442 157186 89935656
Dysuria 25.50 9.41 350 535255 39051 90053791
Product preparation issue 25.48 9.41 48 535557 2298 90090544
Restless legs syndrome 25.40 9.41 223 535382 22247 90070595
Cholestasis 25.38 9.41 327 535278 35972 90056870
Hyperbilirubinaemia 25.38 9.41 155 535450 13781 90079061
Small intestinal obstruction 25.19 9.41 213 535392 21021 90071821
Blood phosphorus increased 25.15 9.41 69 535536 4249 90088593
Panniculitis 25.11 9.41 29 535576 14429 90078413
Hypocholesterolaemia 25.10 9.41 4 535601 6445 90086397
Adjusted calcium decreased 24.94 9.41 16 535589 212 90092630
Eye pruritus 24.93 9.41 272 535333 28755 90064087
Pulmonary toxicity 24.88 9.41 19 535586 11512 90081330
Poor venous access 24.84 9.41 199 535406 19328 90073514
Cardiogenic shock 24.71 9.41 237 535368 24231 90068611
Anaphylactoid reaction 24.65 9.41 70 535535 4398 90088444
Insomnia 24.64 9.41 1668 533937 331806 89761036
Cold sweat 24.63 9.41 155 535450 13926 90078916
Product packaging confusion 24.62 9.41 16 535589 217 90092625
Glomerular filtration rate decreased 24.59 9.41 178 535427 16754 90076088
Rectal haemorrhage 24.59 9.41 652 534953 82092 90010750
Drug dose omission by device 24.56 9.41 15 535590 10216 90082626
Tachyarrhythmia 24.47 9.41 79 535526 5327 90087515
Supraventricular tachycardia 24.46 9.41 173 535432 16163 90076679
Oral pain 24.38 9.41 298 535307 32385 90060457
Abnormal behaviour 24.26 9.41 222 535383 22406 90070436
Incorrect drug administration rate 24.26 9.41 77 535528 5146 90087696
Blindness 24.24 9.41 252 535353 26316 90066526
Arterial haemorrhage 24.21 9.41 49 535556 2474 90090368
Coagulation time prolonged 24.11 9.41 39 535566 1651 90091191
Lung cyst 24.07 9.41 21 535584 454 90092388
Haemodialysis 24.01 9.41 109 535496 8638 90084204
Food allergy 24.01 9.41 74 535531 25404 90067438
Polyarthritis 23.87 9.41 45 535560 18305 90074537
Drug ineffective for unapproved indication 23.87 9.41 265 535340 66379 90026463
Peritonitis bacterial 23.80 9.41 76 535529 5095 90087747
Multiple organ dysfunction syndrome 23.75 9.41 550 535055 67786 90025056
Product substitution issue 23.72 9.41 185 535420 17823 90075019
Haematoma 23.72 9.41 343 535262 38705 90054137
Hepatic cyst 23.67 9.41 89 535516 6479 90086363
Gingival bleeding 23.60 9.41 160 535445 14743 90078099
Pancreatic steatosis 23.58 9.41 38 535567 1604 90091238
Maternal exposure before pregnancy 23.53 9.41 19 535586 11194 90081648
Cerebral haematoma 23.47 9.41 67 535538 4222 90088620
Seasonal allergy 23.40 9.41 223 535382 22760 90070082
Product blister packaging issue 23.38 9.41 18 535587 324 90092518
Drug clearance decreased 23.36 9.41 41 535564 1857 90090985
Anaphylactic reaction 23.30 9.41 680 534925 86844 90005998
Chronic sinusitis 23.27 9.41 229 535376 23573 90069269
Sinus tachycardia 23.04 9.41 264 535341 28249 90064593
Diverticulum intestinal 22.95 9.41 111 535494 9031 90083811
Incorrect route of product administration 22.93 9.41 190 535415 50436 90042406
Stupor 22.93 9.41 78 535527 5404 90087438
Urine output increased 22.91 9.41 39 535566 1723 90091119
Malabsorption 22.84 9.41 75 535530 5103 90087739
Amnesia 22.84 9.41 478 535127 108027 89984815
Cellulitis 22.80 9.41 704 534901 90633 90002209
Appendicitis 22.72 9.41 120 535485 10111 90082731
Deformity 22.70 9.41 23 535582 12147 90080695
Procedural pain 22.69 9.41 299 535306 33061 90059781
Nephroangiosclerosis 22.68 9.41 15 535590 210 90092632
Pulmonary oedema 22.62 9.41 503 535102 61577 90031265
Rebound acid hypersecretion 22.57 9.41 18 535587 342 90092500
Dialysis 22.56 9.41 129 535476 11200 90081642
Large intestine infection 22.47 9.41 49 535556 2608 90090234
Blood potassium increased 22.47 9.41 204 535401 20545 90072297
Cerebrovascular accident 22.38 9.41 918 534687 122615 89970227
Respiratory disorder 22.32 9.41 260 535345 64556 90028286
Multiple-drug resistance 22.28 9.41 9 535596 7767 90085075
Protein total decreased 22.27 9.41 92 535513 6997 90085845
Calcium deficiency 22.15 9.41 33 535572 1300 90091542
Hospitalisation 22.09 9.41 947 534658 127153 89965689
Pneumothorax 22.07 9.41 191 535414 18976 90073866
Decreased appetite 22.03 9.41 2545 533060 373995 89718847
Drug reaction with eosinophilia and systemic symptoms 21.92 9.41 365 535240 42393 90050449
Metastases to lymph nodes 21.91 9.41 22 535583 11667 90081175
Hypoalbuminaemia 21.88 9.41 165 535440 15732 90077110
Infusion site swelling 21.75 9.41 131 535474 11589 90081253
Pneumonia 21.70 9.41 4181 531424 633878 89458964
Pain of skin 21.62 9.41 166 535439 15916 90076926
Erdheim-Chester disease 21.61 9.41 10 535595 65 90092777
Haemoptysis 21.57 9.41 296 535309 33024 90059818
Swelling of eyelid 21.42 9.41 76 535529 5378 90087464
Thrombosis 21.42 9.41 576 535029 72675 90020167
Device related infection 21.40 9.41 240 535365 25546 90067296
Blood phosphorus decreased 21.39 9.41 72 535533 4962 90087880
Fatigue 21.35 9.41 6291 529314 1147732 88945110
Hypovolaemia 21.22 9.41 136 535469 12295 90080547
Oliguria 21.17 9.41 121 535484 10503 90082339
Gastrointestinal sounds abnormal 21.12 9.41 67 535538 4476 90088366
Seroma 21.01 9.41 52 535553 3008 90089834
International normalised ratio abnormal 20.98 9.41 60 535545 3785 90089057
Anal incontinence 20.97 9.41 166 535439 16064 90076778
Oxygen saturation decreased 20.93 9.41 805 534800 106678 89986164
Gastrointestinal stoma complication 20.90 9.41 45 535560 2374 90090468
Limb reduction defect 20.86 9.41 22 535583 606 90092236
Giardiasis 20.86 9.41 11 535594 98 90092744
Nephrectomy 20.85 9.41 40 535565 1941 90090901
Hypergastrinaemia 20.84 9.41 12 535593 129 90092713
Vaginal flatulence 20.80 9.41 137 535468 12501 90080341
Hepatic encephalopathy 20.71 9.41 146 535459 13626 90079216
Suicide attempt 20.67 9.41 317 535288 75082 90017760
Respiratory distress 20.54 9.41 334 535271 38612 90054230
Bradykinesia 20.47 9.41 87 535518 6701 90086141
Labelled drug-drug interaction medication error 20.44 9.41 152 535453 14430 90078412
Hyperaemia 20.41 9.41 47 535558 2595 90090247
Blood immunoglobulin E increased 20.33 9.41 65 535540 4360 90088482
Neonatal infection 20.31 9.41 15 535590 253 90092589
Peripheral circulatory failure 20.20 9.41 35 535570 1569 90091273
Product deposit 20.17 9.41 17 535588 350 90092492
Blood albumin decreased 20.17 9.41 169 535436 16634 90076208
Mood swings 20.16 9.41 199 535406 20503 90072339
Aortic valve stenosis 20.14 9.41 63 535542 4177 90088665
Neck pain 20.07 9.41 516 535089 113447 89979395
Cardio-respiratory arrest 20.07 9.41 502 535103 62638 90030204
Infusion site haemorrhage 20.07 9.41 74 535531 5337 90087505
Anuria 19.95 9.41 153 535452 14665 90078177
Blood pressure diastolic decreased 19.94 9.41 86 535519 26740 90066102
Blood glucose increased 19.91 9.41 719 534886 94527 89998315
Hepatitis 19.88 9.41 296 535309 70443 90022399
Spondylolysis 19.79 9.41 12 535593 143 90092699
Pulmonary function test decreased 19.74 9.41 65 535540 4429 90088413
Eye infection 19.65 9.41 148 535457 14106 90078736
Blood parathyroid hormone decreased 19.64 9.41 26 535579 12190 90080652
Dyskinesia 19.52 9.41 314 535291 36220 90056622
Cholecystitis 19.20 9.41 169 535436 16871 90075971
Hepatitis acute 19.14 9.41 120 535485 10767 90082075
Tongue blistering 19.14 9.41 38 535567 1892 90090950
Abnormal weight gain 19.05 9.41 46 535559 2619 90090223
Listless 19.01 9.41 52 535553 3197 90089645
Dermatitis bullous 18.95 9.41 115 535490 10201 90082641
Aphasia 18.94 9.41 357 535248 42455 90050387
Malnutrition 18.86 9.41 180 535425 18378 90074464
Emotional distress 18.81 9.41 313 535292 36349 90056493
Respiratory syncytial virus infection 18.73 9.41 116 535489 10364 90082478
Skin exfoliation 18.73 9.41 530 535075 67383 90025459
Therapeutic product ineffective 18.71 9.41 43 535562 2371 90090471
Quadriplegia 18.70 9.41 41 535564 2190 90090652
Ischaemic hepatitis 18.69 9.41 47 535558 2746 90090096
Haematochezia 18.61 9.41 550 535055 70363 90022479
Weight decreased 18.51 9.41 2539 533066 377371 89715471
Moraxella test positive 18.47 9.41 7 535598 25 90092817
Inflammatory marker increased 18.40 9.41 105 535500 9109 90083733
Infusion site erythema 18.32 9.41 141 535464 13529 90079313
Congenital ovarian anomaly 18.30 9.41 6 535599 12 90092830
Hypotonia 18.29 9.41 123 535482 11303 90081539
Cerebral haemorrhage 18.18 9.41 296 535309 34226 90058616
Lipase increased 18.02 9.41 120 535485 10991 90081851
Intestinal obstruction 17.96 9.41 314 535291 36817 90056025
Extensor plantar response 17.79 9.41 31 535574 1396 90091446
Lung consolidation 17.79 9.41 66 535539 4774 90088068
Blood creatine increased 17.79 9.41 85 535520 6882 90085960
Talipes 17.78 9.41 34 535571 1646 90091196
Rash vesicular 17.76 9.41 52 535553 18145 90074697
Depressed mood 17.69 9.41 405 535200 49817 90043025
Gallbladder adenocarcinoma 17.65 9.41 10 535595 104 90092738
Goitre 17.60 9.41 83 535522 6684 90086158
Clostridium difficile colitis 17.60 9.41 238 535367 26468 90066374
Radiculopathy 17.59 9.41 177 535428 18328 90074514
Leukocytosis 17.56 9.41 269 535336 30721 90062121
Proctitis 17.54 9.41 152 535453 15107 90077735
Full blood count abnormal 17.53 9.41 309 535296 36288 90056554
Poor peripheral circulation 17.48 9.41 58 535547 3967 90088875
Skin test positive 17.48 9.41 24 535581 876 90091966
Suspected product contamination 17.47 9.41 9 535596 76 90092766
Ascites 17.45 9.41 387 535218 47353 90045489
Respiratory tract infection 17.40 9.41 465 535140 58613 90034229
Feeding disorder 17.37 9.41 169 535436 17343 90075499
Catatonia 17.37 9.41 7 535598 6049 90086793
Incorrect product formulation administered 17.33 9.41 12 535593 182 90092660
Eyelid retraction 17.18 9.41 9 535596 79 90092763
Facial discomfort 17.16 9.41 15 535590 325 90092517
Acute pulmonary oedema 17.10 9.41 106 535499 9474 90083368
Female genital tract fistula 17.03 9.41 171 535434 17697 90075145
Genital ulceration 17.03 9.41 26 535579 1047 90091795
Spinal fusion surgery 16.98 9.41 29 535576 12254 90080588
Blood electrolytes abnormal 16.90 9.41 27 535578 1131 90091711
Blood cholesterol decreased 16.77 9.41 36 535569 1895 90090947
Prothrombin time prolonged 16.74 9.41 107 535498 9665 90083177
Pleural effusion 16.72 9.41 816 534789 111175 89981667
Sleep apnoea syndrome 16.64 9.41 272 535333 31475 90061367
Anaphylactic shock 16.62 9.41 271 535334 31346 90061496
Lactic acidosis 16.57 9.41 403 535202 50060 90042782
Nephropathy toxic 16.52 9.41 130 535475 12558 90080284
Carpal tunnel syndrome 16.49 9.41 215 535390 23713 90069129
Infective exacerbation of bronchiectasis 16.46 9.41 17 535588 457 90092385
Sputum retention 16.45 9.41 20 535585 646 90092196
Photopsia 16.41 9.41 66 535539 4958 90087884
Schizoaffective disorder 16.39 9.41 5 535600 5142 90087700
Cutaneous lupus erythematosus 16.38 9.41 48 535557 3070 90089772
Bone pain 16.34 9.41 481 535124 61502 90031340
Thermohypoaesthesia 16.22 9.41 10 535595 123 90092719
Caesarean section 16.09 9.41 56 535549 18521 90074321
Hepatitis cholestatic 16.09 9.41 96 535509 8465 90084377
Iron deficiency anaemia 16.06 9.41 212 535393 23450 90069392
Product formulation issue 16.04 9.41 20 535585 663 90092179
Pregnancy with contraceptive device 15.99 9.41 5 535600 5061 90087781
Gastrointestinal erosion 15.99 9.41 21 535584 734 90092108
Mental status changes 15.96 9.41 361 535244 44318 90048524
Unintentional medical device removal 15.93 9.41 11 535594 7019 90085823
Suspected product quality issue 15.92 9.41 16 535589 416 90092426
Extrasystoles 15.91 9.41 71 535534 5586 90087256
Mental disorder 15.88 9.41 274 535331 32044 90060798
Body height decreased 15.87 9.41 123 535482 11826 90081016
Limb hypoplasia congenital 15.82 9.41 12 535593 211 90092631
Acute psychosis 15.81 9.41 47 535558 3031 90089811
Product distribution issue 15.75 9.41 53 535552 3652 90089190
Erythema multiforme 15.69 9.41 125 535480 12121 90080721
Intravascular haemolysis 15.67 9.41 16 535589 424 90092418
Duodenitis 15.62 9.41 59 535546 4304 90088538
Intestinal dilatation 15.59 9.41 39 535566 2271 90090571
Type I hypersensitivity 15.56 9.41 57 535548 4098 90088744
Respirovirus test positive 15.51 9.41 6 535599 23 90092819
Essential tremor 15.47 9.41 29 535576 1383 90091459
Blood electrolytes decreased 15.44 9.41 30 535575 1470 90091372
Indifference 15.44 9.41 11 535594 175 90092667
Multimorbidity 15.40 9.41 19 535586 623 90092219
Mood altered 15.35 9.41 162 535443 16982 90075860
Oedematous pancreatitis 15.35 9.41 21 535584 764 90092078
Internal haemorrhage 15.24 9.41 75 535530 6145 90086697
Ischaemic contracture of the left ventricle 15.24 9.41 10 535595 138 90092704
Generalised oedema 15.21 9.41 176 535429 18877 90073965
Cardiac disorder 15.17 9.41 442 535163 56430 90036412
Restlessness 15.16 9.41 296 535309 35424 90057418
Anticholinergic syndrome 15.16 9.41 43 535562 2700 90090142
Oesophageal irritation 15.15 9.41 14 535591 327 90092515
Potentiating drug interaction 15.13 9.41 70 535535 5592 90087250
Hand-eye coordination impaired 15.12 9.41 6 535599 25 90092817
Reduced facial expression 15.08 9.41 41 535564 2512 90090330
Troponin I increased 15.06 9.41 41 535564 2514 90090328
Vulvovaginal ulceration 14.93 9.41 6 535599 26 90092816
Neuroglycopenia 14.93 9.41 25 535580 1090 90091752
Norovirus test positive 14.91 9.41 12 535593 231 90092611
Urinary tract infection pseudomonal 14.90 9.41 23 535582 935 90091907
Renal cyst 14.89 9.41 129 535476 12821 90080021
Magnesium deficiency 14.84 9.41 20 535585 717 90092125
Second primary malignancy 14.82 9.41 24 535581 10354 90082488
Catarrh 14.81 9.41 31 535574 1603 90091239
Atrioventricular block 14.78 9.41 96 535509 8719 90084123
Sight disability 14.76 9.41 10 535595 146 90092696
Vitamin B12 deficiency 14.75 9.41 85 535520 7401 90085441
Vaginal discharge 14.75 9.41 178 535427 19286 90073556
Groin pain 14.75 9.41 123 535482 12090 90080752
Dermatitis allergic 14.71 9.41 162 535443 17165 90075677
Critical illness 14.71 9.41 13 535592 286 90092556
Memory impairment 14.65 9.41 986 534619 196258 89896584
Sepsis syndrome 14.63 9.41 23 535582 950 90091892
Escherichia infection 14.61 9.41 151 535454 15744 90077098
Gastrointestinal polyp 14.59 9.41 10 535595 149 90092693
Avian influenza 14.56 9.41 8 535597 78 90092764
Ear infection 14.50 9.41 308 535297 69467 90023375
Gastric antral vascular ectasia 14.46 9.41 21 535584 808 90092034
Otospondylomegaepiphyseal dysplasia 14.44 9.41 9 535596 113 90092729
Acute myocardial infarction 14.43 9.41 288 535317 34602 90058240
Wrong product administered 14.43 9.41 86 535519 7579 90085263
Renal function test abnormal 14.40 9.41 82 535523 7109 90085733
Cerebrovascular arteriovenous malformation 14.39 9.41 8 535597 80 90092762
Anal haemorrhage 14.37 9.41 40 535565 2484 90090358
Blast cells present 14.33 9.41 17 535588 535 90092307
Post transplant lymphoproliferative disorder 14.31 9.41 12 535593 6937 90085905
Developmental hip dysplasia 14.29 9.41 30 535575 1555 90091287
Throat irritation 14.26 9.41 383 535222 48312 90044530
Aquagenic pruritus 14.25 9.41 6 535599 30 90092812
Hypomania 14.24 9.41 19 535586 8878 90083964
Respiratory rate increased 14.24 9.41 151 535454 15850 90076992
Drug level increased 14.24 9.41 237 535368 27525 90065317
Intraocular pressure test 14.23 9.41 7 535598 53 90092789
Petechiae 14.22 9.41 149 535456 15592 90077250
Drug dose titration not performed 14.12 9.41 20 535585 752 90092090
Fear of eating 14.11 9.41 15 535590 417 90092425
Endoscopy abnormal 14.09 9.41 5 535600 14 90092828
Bromhidrosis 14.09 9.41 5 535600 14 90092828
Air embolism 14.09 9.41 14 535591 359 90092483
Splenic injury 14.06 9.41 11 535594 203 90092639
Blood pH decreased 14.04 9.41 40 535565 2518 90090324
Device infusion issue 14.01 9.41 41 535564 2621 90090221
Eye pain 13.99 9.41 351 535254 43817 90049025
Insulin autoimmune syndrome 13.98 9.41 10 535595 160 90092682
Blood chloride decreased 13.95 9.41 74 535531 6245 90086597
Intracranial haemangioma 13.94 9.41 6 535599 32 90092810
Drug abuse 13.93 9.41 375 535230 81972 90010870
Product prescribing error 13.90 9.41 253 535352 29892 90062950
Viral diarrhoea 13.88 9.41 11 535594 207 90092635
Clonus 13.85 9.41 69 535536 5681 90087161
Inability to afford medication 13.83 9.41 50 535555 3572 90089270
Food aversion 13.82 9.41 27 535578 1328 90091514
Deafness bilateral 13.82 9.41 31 535574 1682 90091160
Exposure to toxic agent 13.82 9.41 16 535589 7951 90084891
Urine chloride decreased 13.82 9.41 8 535597 87 90092755
Erythrodermic psoriasis 13.75 9.41 24 535581 1082 90091760
Dermatitis exfoliative 13.74 9.41 67 535538 5469 90087373
Ulcer 13.74 9.41 126 535479 32756 90060086
False positive investigation result 13.71 9.41 20 535585 773 90092069
Congenital oral malformation 13.70 9.41 11 535594 211 90092631
Gallbladder disorder 13.68 9.41 178 535427 19625 90073217
Vasculitis 13.65 9.41 199 535406 22494 90070348
Incoherent 13.65 9.41 62 535543 4915 90087927
Menstrual disorder 13.64 9.41 72 535533 6066 90086776
Carbon dioxide decreased 13.60 9.41 42 535563 2766 90090076
Nikolsky's sign 13.58 9.41 8 535597 90 90092752
Laryngospasm 13.57 9.41 47 535558 3286 90089556
Starvation ketoacidosis 13.57 9.41 11 535594 214 90092628
Sensory loss 13.56 9.41 165 535440 17910 90074932
Catheter site haemorrhage 13.47 9.41 50 535555 3618 90089224
Head injury 13.43 9.41 259 535346 30929 90061913
Cystic fibrosis lung 13.43 9.41 9 535596 129 90092713
Derailment 13.41 9.41 7 535598 61 90092781
Gastroenteritis 13.37 9.41 245 535360 28984 90063858
Acinetobacter test positive 13.36 9.41 8 535597 93 90092749
Renal atrophy 13.32 9.41 32 535573 1816 90091026
Gastrointestinal mucosal exfoliation 13.31 9.41 9 535596 131 90092711
Occult blood positive 13.26 9.41 53 535552 3970 90088872
Enterocolitis infectious 13.23 9.41 34 535571 2013 90090829
Spinal fracture 13.21 9.41 193 535412 21823 90071019
Gingival pain 13.18 9.41 100 535505 9552 90083290
Urethritis noninfective 13.16 9.41 5 535600 18 90092824
Cleft palate 13.16 9.41 26 535579 1290 90091552
Product administration interrupted 13.11 9.41 122 535483 12370 90080472
Myocardial reperfusion injury 13.08 9.41 9 535596 135 90092707
Rheumatoid lung 13.04 9.41 4 535601 4099 90088743
Achromobacter infection 13.03 9.41 7 535598 65 90092777
Nasal polyps 13.02 9.41 28 535577 10852 90081990
Amaurosis 13.01 9.41 20 535585 810 90092032
Bronchospasm 13.01 9.41 183 535422 20526 90072316
Nephrogenic anaemia 12.99 9.41 38 535567 2428 90090414
Gastrointestinal stoma output increased 12.99 9.41 17 535588 592 90092250
Eye swelling 12.98 9.41 245 535360 29141 90063701
Skin swelling 12.97 9.41 75 535530 6539 90086303
Endocrine ophthalmopathy 12.96 9.41 23 535582 1051 90091791
Respiratory tract procedural complication 12.95 9.41 5 535600 19 90092823
Pyonephrosis 12.95 9.41 5 535600 19 90092823
Hospice care 12.95 9.41 100 535505 9604 90083238
Cardiac assistance device user 12.94 9.41 7 535598 66 90092776
Rash rubelliform 12.92 9.41 4 535601 6 90092836
Oesophageal adenocarcinoma 12.90 9.41 10 535595 182 90092660
Oral discomfort 12.88 9.41 106 535499 10377 90082465
Nasal oedema 12.80 9.41 12 535593 6572 90086270
Peripheral coldness 12.78 9.41 132 535473 13760 90079082
Xeroderma 12.78 9.41 13 535592 343 90092499
Wound dehiscence 12.73 9.41 68 535537 5754 90087088
Papule 12.72 9.41 86 535519 7916 90084926
Renal pain 12.70 9.41 84 535521 7675 90085167
Biliary dyskinesia 12.70 9.41 39 535566 2560 90090282
Ageusia 12.61 9.41 148 535457 15928 90076914
Atrioventricular block second degree 12.61 9.41 56 535549 4396 90088446
Oral mucosal blistering 12.60 9.41 77 535528 6847 90085995
Cardiac steatosis 12.59 9.41 6 535599 42 90092800
Blood lactic acid increased 12.59 9.41 92 535513 8686 90084156
Central nervous system injury 12.59 9.41 9 535596 144 90092698
Poor quality product administered 12.58 9.41 52 535553 3956 90088886
Staphylococcus test positive 12.57 9.41 55 535550 4290 90088552
Cholangitis 12.52 9.41 79 535526 7103 90085739
Inappropriate schedule of product administration 12.52 9.41 1039 534566 148894 89943948
Stoma site infection 12.51 9.41 21 535584 917 90091925
Paralysis 12.50 9.41 113 535492 11365 90081477
Beta haemolytic streptococcal infection 12.50 9.41 38 535567 2481 90090361
Hypothermia 12.49 9.41 144 535461 15431 90077411
DNA antibody 12.48 9.41 6 535599 43 90092799
Amylase increased 12.46 9.41 78 535527 6994 90085848
Myoglobin blood increased 12.42 9.41 28 535577 1524 90091318
Vanishing bile duct syndrome 12.40 9.41 26 535579 1346 90091496
Gastrointestinal infection 12.39 9.41 109 535496 10881 90081961
Pancreatitis chronic 12.38 9.41 41 535564 2802 90090040
Metastases to bone 12.35 9.41 94 535511 25411 90067431
Sopor 12.33 9.41 90 535515 24554 90068288
Aphonia 12.28 9.41 119 535486 12200 90080642
Feeling jittery 12.28 9.41 142 535463 15229 90077613
Therapy partial responder 12.27 9.41 78 535527 21965 90070877
Pneumonia streptococcal 12.26 9.41 34 535571 2107 90090735
Delirium 12.26 9.41 498 535107 103861 89988981
Choluria 12.23 9.41 11 535594 248 90092594
Bradyphrenia 12.22 9.41 82 535523 7530 90085312
Obstructive airways disorder 12.22 9.41 96 535509 25773 90067069
Drug use disorder 12.19 9.41 19 535586 8324 90084518
Lipidosis 12.14 9.41 6 535599 46 90092796
Mouth haemorrhage 12.13 9.41 89 535516 8412 90084430
Cholestasis of pregnancy 12.12 9.41 28 535577 1549 90091293
Psoriasis 12.11 9.41 732 534873 147022 89945820
Infective exacerbation of chronic obstructive airways disease 12.11 9.41 27 535578 1459 90091383
Sinonasal obstruction 12.08 9.41 11 535594 252 90092590
Productive cough 12.03 9.41 564 535041 76499 90016343
Thinking abnormal 12.02 9.41 114 535491 11618 90081224
Accidental exposure to product 12.00 9.41 177 535428 42189 90050653
Acute respiratory distress syndrome 11.94 9.41 237 535368 28449 90064393
Parkinsonian rest tremor 11.93 9.41 9 535596 157 90092685
Blood urea nitrogen/creatinine ratio decreased 11.91 9.41 8 535597 115 90092727
Mean cell volume abnormal 11.91 9.41 14 535591 436 90092406
Nephrocalcinosis 11.91 9.41 24 535581 1208 90091634
Dental discomfort 11.88 9.41 15 535590 504 90092338
Left ventricular failure 11.87 9.41 74 535531 6626 90086216
Blood albumin abnormal 11.85 9.41 23 535582 1126 90091716
Epigastric discomfort 11.83 9.41 81 535524 7487 90085355
Joint abscess 11.81 9.41 14 535591 440 90092402
Abdominal infection 11.81 9.41 36 535569 2354 90090488
Urine osmolarity increased 11.80 9.41 8 535597 117 90092725
Distal intestinal obstruction syndrome 11.79 9.41 15 535590 508 90092334
Urine sodium decreased 11.74 9.41 9 535596 161 90092681
Hypovolaemic shock 11.74 9.41 77 535528 7017 90085825
Polymenorrhagia 11.72 9.41 6 535599 50 90092792
Leukopenia 11.71 9.41 717 534888 99993 89992849
Blood pressure abnormal 11.71 9.41 172 535433 19473 90073369
Skin infection 11.69 9.41 159 535446 17705 90075137
Hypoproteinaemia 11.68 9.41 43 535562 3099 90089743
Skin texture abnormal 11.68 9.41 16 535589 583 90092259
Muscle contractions involuntary 11.67 9.41 41 535564 2887 90089955
Viral infection 11.64 9.41 324 535281 41090 90051752
Target skin lesion 11.63 9.41 8 535597 120 90092722
Intraductal papillary breast neoplasm 11.60 9.41 4 535601 10 90092832
Injection site granuloma 11.57 9.41 7 535598 83 90092759
COVID-19 pneumonia 11.57 9.41 161 535444 18016 90074826
Face oedema 11.57 9.41 198 535407 23120 90069722
Mucosal inflammation 11.55 9.41 433 535172 57192 90035650
Unintended pregnancy 11.54 9.41 17 535588 7620 90085222
Poliomyelitis 11.52 9.41 6 535599 52 90092790
Retching 11.52 9.41 168 535437 18991 90073851
Superior mesenteric artery syndrome 11.51 9.41 8 535597 122 90092720
Idiopathic pulmonary fibrosis 11.51 9.41 28 535577 1602 90091240
Thrombosis mesenteric vessel 11.50 9.41 7 535598 84 90092758
Renal neoplasm 11.50 9.41 27 535578 1510 90091332
Red blood cell count decreased 11.49 9.41 357 535248 45994 90046848
Mucosal dryness 11.48 9.41 43 535562 3124 90089718
Hypersomnia 11.48 9.41 185 535420 21346 90071496
Product selection error 11.46 9.41 11 535594 270 90092572
Withdrawal syndrome 11.45 9.41 192 535413 22332 90070510
Creatinine renal clearance increased 11.45 9.41 44 535561 3237 90089605
Acquired cystic kidney disease 11.33 9.41 6 535599 54 90092788
Anaemia folate deficiency 11.28 9.41 15 535590 531 90092311
Adrenal calcification 11.27 9.41 5 535600 29 90092813
Infusion site infection 11.26 9.41 38 535567 2622 90090220
Staphylococcal infection 11.21 9.41 370 535235 48069 90044773
Formication 11.20 9.41 57 535548 4734 90088108
Apathy 11.18 9.41 107 535498 10933 90081909
Postoperative wound infection 11.16 9.41 125 535480 13301 90079541
Blood phosphorus abnormal 11.15 9.41 9 535596 174 90092668
Enzyme induction 11.14 9.41 6 535599 56 90092786
Vulvar basal cell carcinoma 11.13 9.41 5 535600 30 90092812
Neutrophil percentage decreased 11.13 9.41 15 535590 538 90092304
Salmonellosis 11.08 9.41 24 535581 1271 90091571
Asthma 11.08 9.41 1257 534348 240903 89851939
Perineal cellulitis 11.07 9.41 4 535601 12 90092830
Urticaria vesiculosa 11.07 9.41 4 535601 12 90092830
Postresuscitation encephalopathy 11.07 9.41 4 535601 12 90092830
Eosinophilic cellulitis 11.06 9.41 10 535595 227 90092615
Lichen planus 11.06 9.41 39 535566 2752 90090090
Immune effector cell-associated neurotoxicity syndrome 11.04 9.41 65 535540 5703 90087139
Infusion site thrombosis 11.02 9.41 9 535596 177 90092665
Electrocardiogram abnormal 11.02 9.41 101 535504 10197 90082645
Allergic reaction to excipient 10.99 9.41 18 535587 770 90092072
Infusion site rash 10.98 9.41 36 535569 2447 90090395
Renal tubular necrosis 10.98 9.41 133 535472 14422 90078420
Cholecystectomy 10.96 9.41 112 535493 11643 90081199
Myxofibrosarcoma 10.96 9.41 7 535598 92 90092750
Brain death 10.96 9.41 50 535555 3971 90088871
Surgery 10.94 9.41 345 535260 44542 90048300
Infusion site pruritus 10.93 9.41 73 535532 6692 90086150
Toxic shock syndrome 10.89 9.41 21 535584 1023 90091819
Failure to thrive 10.85 9.41 86 535519 8325 90084517
Ligament sprain 10.84 9.41 133 535472 14466 90078376
Splenic calcification 10.84 9.41 4 535601 13 90092829
Oesophageal disorder 10.82 9.41 38 535567 2675 90090167
Therapeutic product ineffective for unapproved indication 10.82 9.41 11 535594 290 90092552
Back disorder 10.80 9.41 98 535507 25533 90067309
Mucosal discolouration 10.76 9.41 16 535589 629 90092213
Calciphylaxis 10.75 9.41 44 535561 3332 90089510
Hypertensive cardiomyopathy 10.73 9.41 11 535594 293 90092549
Localised infection 10.71 9.41 267 535338 33295 90059547
Soft tissue disorder 10.71 9.41 6 535599 4284 90088558
Gastric mucosal hypertrophy 10.71 9.41 7 535598 96 90092746
Tracheo-oesophageal fistula 10.70 9.41 17 535588 709 90092133
Food poisoning 10.67 9.41 59 535546 5059 90087783
Product preparation error 10.66 9.41 100 535505 10161 90082681
Septic arthritis staphylococcal 10.63 9.41 15 535590 562 90092280
Crystal nephropathy 10.63 9.41 22 535583 1129 90091713
Oral blood blister 10.62 9.41 6 535599 62 90092780
Truncus coeliacus thrombosis 10.62 9.41 4 535601 14 90092828
Achlorhydria 10.62 9.41 4 535601 14 90092828
Ear, nose and throat examination abnormal 10.62 9.41 4 535601 14 90092828
Differential white blood cell count abnormal 10.61 9.41 20 535585 958 90091884
Zinc deficiency 10.58 9.41 7 535598 98 90092744
Bacteraemia 10.58 9.41 188 535417 22112 90070730
Confusion postoperative 10.57 9.41 10 535595 241 90092601
Extravasation 10.55 9.41 40 535565 2924 90089918
Mental status changes postoperative 10.53 9.41 9 535596 189 90092653
Chronic spontaneous urticaria 10.52 9.41 29 535576 1791 90091051
Hyperventilation 10.51 9.41 72 535533 6656 90086186
Monoclonal immunoglobulin present 10.50 9.41 32 535573 2092 90090750
Sensation of foreign body 10.47 9.41 69 535536 6297 90086545
Oroantral fistula 10.45 9.41 9 535596 191 90092651
Myocardial infarction 10.44 9.41 744 534861 105228 89987614
Psychiatric symptom 10.44 9.41 75 535530 7043 90085799
Arteriovenous fistula operation 10.43 9.41 10 535595 245 90092597
Pituitary tumour benign 10.43 9.41 32 535573 2100 90090742
Tongue discomfort 10.41 9.41 38 535567 2727 90090115
Poor sucking reflex 10.40 9.41 13 535592 432 90092410
Immunoglobulins abnormal 10.39 9.41 8 535597 144 90092698
Peritonitis 10.39 9.41 169 535436 19536 90073306
Blood calcitonin increased 10.38 9.41 5 535600 36 90092806
Campylobacter sepsis 10.35 9.41 3 535602 3 90092839
Occupational problem environmental 10.35 9.41 3 535602 3 90092839
Joint effusion 10.34 9.41 71 535534 19639 90073203
Lung adenocarcinoma stage IV 10.29 9.41 13 535592 437 90092405
Rash erythematous 10.27 9.41 477 535128 64627 90028215
Sexual dysfunction 10.26 9.41 8 535597 4796 90088046
Diffuse large B-cell lymphoma recurrent 10.24 9.41 4 535601 3522 90089320
Device dislocation 10.19 9.41 128 535477 31354 90061488
Adrenal suppression 10.17 9.41 20 535585 989 90091853
Aortic arteriosclerosis 10.15 9.41 79 535526 7605 90085237
Vascular access site occlusion 10.15 9.41 5 535600 38 90092804
Enterobacter test positive 10.14 9.41 10 535595 254 90092588
Mesenteric artery thrombosis 10.14 9.41 10 535595 254 90092588
Genital neoplasm malignant female 10.12 9.41 8 535597 150 90092692
Fibrin D dimer increased 10.11 9.41 61 535544 5399 90087443
Incision site pain 10.08 9.41 24 535581 1354 90091488
Dyspepsia 10.08 9.41 1021 534584 197139 89895703
Pyogenic granuloma 10.06 9.41 11 535594 316 90092526
Cardiovascular disorder 10.05 9.41 123 535482 13369 90079473
Irritability 10.02 9.41 279 535326 35383 90057459
Obstetric procedure complication 10.02 9.41 4 535601 17 90092825
Hyperphosphataemia 10.01 9.41 46 535559 3665 90089177
Sweat gland disorder 10.00 9.41 7 535598 108 90092734
Nodule 10.00 9.41 105 535500 26581 90066261
Genital erosion 10.00 9.41 13 535592 450 90092392
Intestinal ulcer 9.95 9.41 27 535578 1652 90091190
Long QT syndrome congenital 9.95 9.41 7 535598 109 90092733
Burns second degree 9.95 9.41 30 535575 1950 90090892
Megakaryocytes abnormal 9.94 9.41 5 535600 40 90092802
Oropharyngeal discomfort 9.93 9.41 79 535526 7656 90085186
Lower gastrointestinal haemorrhage 9.92 9.41 88 535517 8804 90084038
Mean cell volume increased 9.88 9.41 57 535548 4964 90087878
Prothrombin level decreased 9.88 9.41 16 535589 678 90092164
Cholangiocarcinoma 9.87 9.41 23 535582 1280 90091562
Bacterial infection 9.86 9.41 194 535411 23250 90069592
Hypoxic-ischaemic encephalopathy 9.86 9.41 54 535551 4614 90088228
Haemorrhage 9.85 9.41 503 535102 68866 90023976
Pulmonary artery atresia 9.84 9.41 4 535601 18 90092824
Gallbladder injury 9.83 9.41 23 535582 1283 90091559
Terminal insomnia 9.81 9.41 22 535583 1193 90091649
Vitamin D deficiency 9.80 9.41 152 535453 17404 90075438
Bladder irritation 9.79 9.41 11 535594 326 90092516
Ovarian germ cell cancer stage II 9.79 9.41 6 535599 73 90092769
Infective myositis 9.79 9.41 6 535599 73 90092769
Eyelid erosion 9.73 9.41 5 535600 42 90092800
Hypotensive crisis 9.72 9.41 6 535599 74 90092768
Salivary gland enlargement 9.72 9.41 12 535593 394 90092448
Congenital anomaly 9.71 9.41 14 535591 6333 90086509
Oropharyngeal blistering 9.70 9.41 20 535585 1023 90091819
Dysphoria 9.70 9.41 66 535539 6088 90086754
Pancreatic enzymes increased 9.70 9.41 18 535587 852 90091990
Suture related complication 9.68 9.41 11 535594 330 90092512
Primary myelofibrosis 9.65 9.41 6 535599 75 90092767
Product dispensing error 9.63 9.41 113 535492 12160 90080682
Infusion site discharge 9.62 9.41 34 535571 2401 90090441
Pathogen resistance 9.62 9.41 21 535584 8094 90084748
Eye irritation 9.60 9.41 266 535339 33712 90059130
pH body fluid abnormal 9.58 9.41 6 535599 76 90092766
Shunt thrombosis 9.58 9.41 6 535599 76 90092766
Myopathy 9.54 9.41 122 535483 13396 90079446
Therapy cessation 9.54 9.41 282 535323 36079 90056763
Hair injury 9.53 9.41 5 535600 44 90092798
Infusion site bruising 9.52 9.41 51 535554 4321 90088521
Skin laceration 9.50 9.41 211 535394 25824 90067018
Haemodialysis complication 9.47 9.41 9 535596 218 90092624
Oesophageal candidiasis 9.47 9.41 71 535534 6758 90086084
Escherichia urinary tract infection 9.47 9.41 124 535481 13691 90079151
Sluggishness 9.45 9.41 64 535541 5895 90086947
Vascular compression 9.44 9.41 10 535595 277 90092565
Dysmorphism 9.42 9.41 35 535570 2533 90090309
Femur fracture 9.41 9.41 347 535258 45735 90047107
Dissociation 9.41 9.41 70 535535 6645 90086197
Encephalitis 9.41 9.41 104 535501 11030 90081812

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypomagnesaemia 728.76 11.05 1066 373902 27422 42218945
Myelosuppression 655.85 11.05 1233 373735 39228 42207139
Drug ineffective 478.08 11.05 3420 371548 626777 41619590
Hypocalcaemia 376.38 11.05 825 374143 29348 42217019
Drug abuse 371.71 11.05 231 374737 104540 42141827
Off label use 317.76 11.05 3847 371121 634488 41611879
Toxicity to various agents 207.03 11.05 1176 373792 227960 42018407
Tubulointerstitial nephritis 205.32 11.05 678 374290 30870 42215497
Infective pulmonary exacerbation of cystic fibrosis 197.59 11.05 291 374677 7527 42238840
Therapeutic product effect incomplete 180.20 11.05 215 374753 70724 42175643
Treatment failure 172.02 11.05 178 374790 62446 42183921
Chronic kidney disease 156.48 11.05 825 374143 46416 42199951
Hyponatraemia 123.96 11.05 1402 373566 100060 42146307
Death 111.33 11.05 3227 371741 467958 41778409
Completed suicide 107.76 11.05 459 374509 96006 42150361
Drug resistance 106.29 11.05 87 374881 34161 42212206
Drug dependence 99.21 11.05 67 374901 29027 42217340
Acute kidney injury 96.04 11.05 4047 370921 363290 41883077
Lower respiratory tract infection 92.75 11.05 651 374317 40555 42205812
Lip swelling 83.62 11.05 361 374607 18692 42227675
Disease progression 80.12 11.05 842 374126 142814 42103553
Hypokalaemia 79.99 11.05 974 373994 70747 42175620
Drug intolerance 78.97 11.05 401 374567 80023 42166344
Suicide attempt 77.80 11.05 182 374786 45918 42200449
Drug use disorder 77.68 11.05 3 374965 10330 42236037
Synovitis 76.59 11.05 21 374947 15546 42230821
White blood cell count decreased 76.57 11.05 1381 373587 109015 42137352
Granulocyte count decreased 76.10 11.05 81 374887 1489 42244878
Product use in unapproved indication 75.67 11.05 1154 373814 183302 42063065
Hypoparathyroidism 72.04 11.05 56 374912 669 42245698
Tetany 70.68 11.05 67 374901 1065 42245302
Foetal exposure during pregnancy 66.10 11.05 205 374763 47106 42199261
Temperature intolerance 65.54 11.05 136 374832 4652 42241715
Cystic fibrosis 64.66 11.05 85 374883 1970 42244397
Therapy partial responder 63.20 11.05 50 374918 19971 42226396
Respiratory tract infection 62.87 11.05 422 374546 25900 42220467
Inappropriate antidiuretic hormone secretion 62.59 11.05 300 374668 16241 42230126
Malignant neoplasm progression 60.96 11.05 634 374334 107766 42138601
Hereditary angioedema 60.72 11.05 70 374898 1411 42244956
Cardiospasm 60.19 11.05 79 374889 1828 42244539
C-reactive protein abnormal 59.83 11.05 6 374962 9255 42237112
Palmoplantar keratoderma 58.55 11.05 85 374883 2169 42244198
Rheumatoid arthritis 56.43 11.05 188 374780 42252 42204115
Blood pressure systolic increased 56.04 11.05 100 374868 27868 42218499
Vomiting 53.96 11.05 3089 371879 286634 41959733
Poisoning 52.64 11.05 32 374936 14667 42231700
Renal tubular acidosis 51.13 11.05 89 374879 2661 42243706
Drug interaction 51.11 11.05 2854 372114 264145 41982222
Osmotic demyelination syndrome 50.45 11.05 53 374915 959 42245408
Therapy non-responder 48.50 11.05 273 374695 53086 42193281
Hypertrichosis 48.45 11.05 41 374927 557 42245810
Immune reconstitution inflammatory syndrome 47.49 11.05 15 374953 10128 42236239
Renal injury 45.22 11.05 221 374747 12059 42234308
Subacute cutaneous lupus erythematosus 44.44 11.05 60 374908 1428 42244939
Drug ineffective for unapproved indication 44.26 11.05 232 374736 45931 42200436
Neutrophil count decreased 43.83 11.05 793 374175 62622 42183745
Neuritis 43.01 11.05 3 374965 6217 42240150
Intercepted product preparation error 42.41 11.05 7 374961 7382 42238985
Pruritus genital 42.19 11.05 80 374888 2559 42243808
Tension headache 42.15 11.05 93 374875 3321 42243046
Hyperpyrexia 42.10 11.05 95 374873 3445 42242922
Abdominal pain upper 41.94 11.05 987 373981 81622 42164745
Cytomegalovirus infection reactivation 40.50 11.05 24 374944 11154 42235213
Rapid correction of hyponatraemia 40.49 11.05 23 374945 154 42246213
Weight increased 40.42 11.05 687 374281 107296 42139071
Therapeutic product effect decreased 40.26 11.05 192 374776 38958 42207409
Multiple-drug resistance 39.73 11.05 8 374960 7314 42239053
Facial pain 39.63 11.05 104 374864 4156 42242211
Immunisation 39.53 11.05 52 374916 1206 42245161
Loss of personal independence in daily activities 38.99 11.05 267 374701 49549 42196818
Blood pressure fluctuation 38.72 11.05 115 374853 26793 42219574
Eosinophilic oesophagitis 38.59 11.05 39 374929 673 42245694
Substance abuse 38.55 11.05 15 374953 8890 42237477
Drug hypersensitivity 38.28 11.05 629 374339 98760 42147607
Overdose 38.01 11.05 674 374294 104590 42141777
Diarrhoea 37.25 11.05 4613 370355 456236 41790131
Obstructive airways disorder 36.95 11.05 104 374864 24655 42221712
Pathogen resistance 36.89 11.05 28 374940 11422 42234945
Sleep terror 36.46 11.05 80 374888 2846 42243521
Atrial tachycardia 36.42 11.05 99 374869 4041 42242326
Intentional overdose 36.32 11.05 284 374684 51172 42195195
Venoocclusive liver disease 36.10 11.05 23 374945 10279 42236088
General physical health deterioration 35.95 11.05 1034 373934 150212 42096155
Aplastic anaemia 35.36 11.05 34 374934 12350 42234017
Psoriatic arthropathy 35.00 11.05 108 374860 24859 42221508
Full blood count abnormal 34.67 11.05 140 374828 29736 42216631
Dyspnoea 34.65 11.05 4422 370546 438199 41808168
Condition aggravated 34.49 11.05 1909 373059 258845 41987522
Muscle twitching 34.48 11.05 199 374769 11581 42234786
Gastric mucosal hypertrophy 33.62 11.05 21 374947 171 42246196
Chest discomfort 33.19 11.05 763 374205 62853 42183514
Sedation 32.79 11.05 147 374821 30328 42216039
Mucormycosis 32.68 11.05 11 374957 7132 42239235
Anosmia 32.56 11.05 110 374858 5066 42241301
Confusional state 31.91 11.05 1791 373177 165806 42080561
Lymphoma 31.68 11.05 48 374920 14273 42232094
Abdominal pain 31.48 11.05 2010 372958 188461 42057906
Coma 31.42 11.05 310 374658 53244 42193123
Gastric polyps 31.23 11.05 55 374913 1660 42244707
Conjunctivitis allergic 30.97 11.05 7 374961 5904 42240463
Interstitial lung disease 30.72 11.05 495 374473 77967 42168400
Eosinophil count 30.28 11.05 20 374948 181 42246186
Blood pressure systolic abnormal 30.08 11.05 6 374962 5522 42240845
Hypoparathyroidism secondary 30.01 11.05 20 374948 184 42246183
Metabolic acidosis 29.91 11.05 631 374337 51227 42195140
Chromaturia 29.44 11.05 241 374727 15748 42230619
Aggression 28.77 11.05 249 374719 43914 42202453
Spinal muscular atrophy 28.64 11.05 26 374942 390 42245977
Mite allergy 28.48 11.05 5 374963 5041 42241326
Blood magnesium decreased 28.42 11.05 139 374829 7587 42238780
Total lung capacity abnormal 28.39 11.05 3 374965 4440 42241927
Coronary artery disease 28.25 11.05 319 374649 53401 42192966
Dysbiosis 28.14 11.05 35 374933 766 42245601
Dysphoria 28.07 11.05 70 374898 2710 42243657
Therapeutic response decreased 27.67 11.05 201 374767 36811 42209556
Tinnitus 27.62 11.05 382 374586 28556 42217811
Swollen tongue 27.54 11.05 297 374671 20934 42225433
End stage renal disease 27.54 11.05 244 374724 16314 42230053
Extrapyramidal disorder 27.52 11.05 65 374903 16347 42230020
Palpitations 27.35 11.05 612 374356 50185 42196182
Diffuse large B-cell lymphoma recurrent 27.23 11.05 5 374963 4881 42241486
Myocardial infarction 27.18 11.05 857 374111 123152 42123215
Hypophosphataemia 26.71 11.05 292 374676 20653 42225714
Tachypnoea 26.26 11.05 299 374669 21363 42225004
Epstein-Barr virus infection 26.25 11.05 28 374940 9690 42236677
Neutrophil count increased 26.14 11.05 278 374690 19526 42226841
Labelled drug-drug interaction medication error 26.12 11.05 230 374738 15352 42231015
Post transplant lymphoproliferative disorder 26.09 11.05 25 374943 9095 42237272
Pyrexia 26.04 11.05 3898 371070 390144 41856223
Neurological symptom 25.65 11.05 30 374938 9961 42236406
Intentional product use issue 25.59 11.05 461 374507 71372 42174995
Gastrooesophageal reflux disease 25.37 11.05 546 374422 44477 42201890
Cytomegalovirus infection 25.35 11.05 173 374795 32133 42214234
Steatorrhoea 25.31 11.05 34 374934 805 42245562
Progressive multifocal leukoencephalopathy 25.20 11.05 39 374929 11497 42234870
Electrolyte imbalance 24.93 11.05 245 374723 16856 42229511
Sopor 24.86 11.05 49 374919 13153 42233214
Premature baby 24.72 11.05 112 374856 23041 42223326
Right hemisphere deficit syndrome 24.63 11.05 9 374959 16 42246351
Migraine 24.46 11.05 336 374632 25078 42221289
Jejunal ulcer perforation 24.31 11.05 13 374955 76 42246291
Swelling face 24.01 11.05 358 374610 27196 42219171
Blood pressure diastolic abnormal 23.89 11.05 12 374956 6116 42240251
Tenosynovitis 23.73 11.05 6 374962 4689 42241678
Hyperparathyroidism secondary 23.68 11.05 51 374917 1791 42244576
Carotid artery occlusion 23.67 11.05 86 374882 4108 42242259
Myalgia 23.49 11.05 1052 373916 95028 42151339
Red blood cell sedimentation rate abnormal 23.49 11.05 3 374965 3833 42242534
Neuroleptic malignant syndrome 23.44 11.05 103 374865 21369 42224998
Superinfection 23.44 11.05 68 374900 2883 42243484
Oesophageal perforation 23.05 11.05 40 374928 1193 42245174
BK virus infection 22.96 11.05 26 374942 8758 42237609
Meconium abnormal 22.88 11.05 12 374956 67 42246300
Chills 22.79 11.05 1029 373939 93037 42153330
Apparent death 22.46 11.05 3 374965 3705 42242662
Multimorbidity 22.42 11.05 34 374934 903 42245464
Blood calcium decreased 22.41 11.05 171 374797 10937 42235430
Sputum increased 22.40 11.05 70 374898 3093 42243274
Gastritis 22.40 11.05 315 374653 23632 42222735
Blood pH abnormal 22.33 11.05 8 374960 13 42246354
Pulmonary alveolar haemorrhage 22.28 11.05 62 374906 14754 42231613
Device leakage 22.24 11.05 35 374933 10250 42236117
Plasma cell myeloma 22.19 11.05 562 374406 47016 42199351
Circulatory collapse 22.14 11.05 311 374657 23325 42223042
Body temperature decreased 21.91 11.05 60 374908 14353 42232014
Polyomavirus-associated nephropathy 21.88 11.05 11 374957 5604 42240763
Soft tissue mass 21.82 11.05 35 374933 977 42245390
Impaired quality of life 21.60 11.05 205 374763 13972 42232395
Exposure during pregnancy 21.59 11.05 26 374942 8522 42237845
Bone erosion 21.55 11.05 6 374962 4397 42241970
Monocyte chemotactic protein-1 increased 21.50 11.05 21 374947 347 42246020
Atopy 21.40 11.05 34 374934 941 42245426
Alpha tumour necrosis factor increased 21.26 11.05 21 374947 352 42246015
Disorganised speech 21.25 11.05 42 374926 1386 42244981
Hyponatraemic encephalopathy 21.03 11.05 11 374957 61 42246306
Immunosuppressant drug level increased 20.96 11.05 128 374840 7603 42238764
Product packaging confusion 20.90 11.05 13 374955 105 42246262
Blood sodium increased 20.78 11.05 69 374899 3149 42243218
Drug level increased 20.77 11.05 335 374633 25865 42220502
Musculoskeletal stiffness 20.48 11.05 371 374597 57394 42188973
Hyperchlorhydria 20.37 11.05 27 374941 631 42245736
Bladder cancer 20.34 11.05 79 374889 16968 42229399
Product preparation issue 20.26 11.05 35 374933 1040 42245327
Blood pressure diastolic increased 20.21 11.05 16 374952 6389 42239978
Graft versus host disease in gastrointestinal tract 20.15 11.05 10 374958 5133 42241234
Pneumonia 20.01 11.05 4104 370864 418045 41828322
Insulin autoimmune syndrome 19.88 11.05 24 374944 509 42245858
Vocal cord dysfunction 19.86 11.05 16 374952 202 42246165
Cough 19.81 11.05 1822 373146 176281 42070086
Rectal haemorrhage 19.74 11.05 574 374394 49032 42197335
Pneumocystis jirovecii pneumonia 19.68 11.05 135 374833 25046 42221321
Acidosis hyperchloraemic 19.67 11.05 27 374941 653 42245714
Occupational dermatitis 19.59 11.05 12 374956 94 42246273
Heart rate decreased 19.57 11.05 216 374752 36316 42210051
Febrile neutropenia 19.57 11.05 1388 373580 184315 42062052
Forced expiratory volume decreased 19.49 11.05 23 374945 7607 42238760
Antineutrophil cytoplasmic antibody positive 19.49 11.05 7 374961 4358 42242009
Rales 19.48 11.05 169 374799 11231 42235136
Joint swelling 19.34 11.05 453 374515 67569 42178798
Nephritis 19.15 11.05 75 374893 3714 42242653
Central nervous system mass 19.13 11.05 30 374938 821 42245546
Cytomegalovirus viraemia 19.13 11.05 39 374929 10338 42236029
Rash papular 19.11 11.05 173 374795 11638 42234729
Lethargy 19.05 11.05 544 374424 46346 42200021
Pancreatic abscess 19.04 11.05 15 374953 183 42246184
Wall motion score index abnormal 19.02 11.05 30 374938 825 42245542
Blood sodium abnormal 19.00 11.05 25 374943 580 42245787
Tetanus 18.90 11.05 10 374958 57 42246310
Sexual dysfunction 18.88 11.05 19 374949 6756 42239611
Mouth ulceration 18.80 11.05 208 374760 14755 42231612
Myelodysplastic syndrome 18.75 11.05 120 374848 22625 42223742
Cystic fibrosis respiratory infection suppression 18.57 11.05 17 374951 258 42246109
Dizziness 18.51 11.05 2483 372485 246771 41999596
Psychiatric decompensation 18.46 11.05 7 374961 4215 42242152
Neutropenic sepsis 18.39 11.05 218 374750 15728 42230639
Prostate cancer 18.36 11.05 279 374689 44364 42202003
Lupus endocarditis 18.35 11.05 6 374962 6 42246361
Hallucination 18.33 11.05 648 374320 56859 42189508
Endophthalmitis 18.33 11.05 8 374960 4425 42241942
Neutropenia 18.27 11.05 1508 373460 197923 42048444
Lipodystrophy acquired 18.25 11.05 4 374964 3446 42242921
Nephrogenic anaemia 18.10 11.05 57 374911 2529 42243838
Therapeutic response shortened 18.04 11.05 60 374908 13494 42232873
Stoma site haemorrhage 17.99 11.05 34 374934 1085 42245282
Brain scan abnormal 17.91 11.05 36 374932 1203 42245164
Suffocation feeling 17.89 11.05 26 374942 664 42245703
Airway remodelling 17.88 11.05 30 374938 870 42245497
Hepatitis B reactivation 17.79 11.05 9 374959 4569 42241798
Multiple sclerosis relapse 17.74 11.05 65 374903 14199 42232168
Sleep disorder due to a general medical condition 17.70 11.05 86 374882 17367 42229000
Hypochromasia 17.70 11.05 18 374950 313 42246054
Syringe issue 17.68 11.05 30 374938 8526 42237841
Product formulation issue 17.68 11.05 28 374940 773 42245594
Degenerative mitral valve disease 17.65 11.05 17 374951 276 42246091
Liver injury 17.56 11.05 251 374717 18897 42227470
Cerebral atrophy congenital 17.48 11.05 10 374958 68 42246299
Product use issue 17.39 11.05 528 374440 76223 42170144
Leukoplakia oral 17.38 11.05 13 374955 146 42246221
Granuloma annulare 17.36 11.05 14 374954 177 42246190
Platelet count decreased 17.32 11.05 1430 373538 137151 42109216
Epilepsy 17.28 11.05 325 374643 25846 42220521
Haematotoxicity 17.25 11.05 45 374923 10940 42235427
Haemophagocytic lymphohistiocytosis 17.23 11.05 92 374876 18130 42228237
Dysmorphism 17.23 11.05 4 374964 3312 42243055
Pain of skin 17.21 11.05 126 374842 7954 42238413
Odynophagia 17.05 11.05 110 374858 6660 42239707
Drug dose omission by device 16.99 11.05 16 374952 5870 42240497
Euphoric mood 16.98 11.05 19 374949 6434 42239933
Uveitis 16.89 11.05 35 374933 9223 42237144
Rheumatoid nodule 16.83 11.05 3 374965 2992 42243375
Catatonia 16.82 11.05 18 374950 6221 42240146
Device malfunction 16.80 11.05 54 374914 12273 42234094
Indifference 16.74 11.05 13 374955 155 42246212
Hypothyroidism 16.68 11.05 191 374777 31893 42214474
Polyneuropathy 16.67 11.05 96 374872 18565 42227802
Lung disorder 16.61 11.05 309 374659 47614 42198753
Coronary artery bypass 16.50 11.05 11 374957 4799 42241568
Myoclonic dystonia 16.47 11.05 10 374958 77 42246290
Herpes simplex 16.46 11.05 23 374945 7072 42239295
Renal cyst haemorrhage 16.46 11.05 25 374943 665 42245702
Acne 16.43 11.05 63 374905 13581 42232786
Psychomotor skills impaired 16.42 11.05 13 374955 5191 42241176
Device use error 16.33 11.05 4 374964 3193 42243174
Bronchopulmonary aspergillosis 16.28 11.05 102 374866 19327 42227040
Haemarthrosis 16.22 11.05 74 374894 3924 42242443
Malignant spinal cord compression 16.17 11.05 12 374956 133 42246234
Epiploic appendagitis 16.12 11.05 9 374959 58 42246309
Lymphangitis 16.09 11.05 24 374944 628 42245739
Choluria 16.08 11.05 13 374955 165 42246202
Respiratory arrest 16.06 11.05 166 374802 28258 42218109
Air embolism 16.05 11.05 15 374953 234 42246133
Blood chromogranin A increased 16.04 11.05 17 374951 311 42246056
Urine calcium decreased 15.97 11.05 6 374962 12 42246355
Renal fusion anomaly 15.85 11.05 10 374958 83 42246284
Hypernatraemia 15.75 11.05 146 374822 9886 42236481
Hypopnoea 15.71 11.05 121 374847 7761 42238606
Disease complication 15.71 11.05 61 374907 3009 42243358
Upper gastrointestinal haemorrhage 15.67 11.05 363 374605 29936 42216431
Priapism 15.65 11.05 20 374948 6387 42239980
Hepatocellular injury 15.64 11.05 133 374835 23545 42222822
Osteonecrosis 15.62 11.05 79 374889 15786 42230581
Drug withdrawal syndrome neonatal 15.58 11.05 10 374958 4451 42241916
Delirium 15.57 11.05 587 374381 51932 42194435
Chronic graft versus host disease 15.57 11.05 18 374950 6007 42240360
Administration site extravasation 15.52 11.05 26 374942 753 42245614
Genital ulceration 15.49 11.05 28 374940 863 42245504
Ventricular flutter 15.47 11.05 10 374958 87 42246280
Viral mutation identified 15.46 11.05 5 374963 3326 42243041
Acute graft versus host disease in skin 15.37 11.05 26 374942 7398 42238969
Iron deficiency anaemia 15.37 11.05 179 374789 12860 42233507
Posthaemorrhagic hydrocephalus 15.35 11.05 11 374957 115 42246252
Virologic failure 15.30 11.05 8 374960 3986 42242381
Second primary malignancy 15.21 11.05 39 374929 9536 42236831
Macrocephaly 15.10 11.05 20 374948 467 42245900
Status epilepticus 15.09 11.05 78 374890 15500 42230867
Abnormal loss of weight 15.09 11.05 85 374883 4902 42241465
COVID-19 treatment 15.07 11.05 15 374953 254 42246113
Acute graft versus host disease in intestine 15.01 11.05 8 374960 3943 42242424
Dry mouth 14.93 11.05 458 374510 39421 42206946
Maternal exposure during pregnancy 14.85 11.05 24 374944 6954 42239413
Eosinophilia 14.79 11.05 202 374766 32697 42213670
Arthropathy 14.69 11.05 178 374790 29419 42216948
Liver function test abnormal 14.63 11.05 381 374587 32010 42214357
Blood immunoglobulin E increased 14.63 11.05 67 374901 3558 42242809
Headache 14.61 11.05 2358 372610 237011 42009356
Antipsychotic drug level below therapeutic 14.54 11.05 5 374963 3199 42243168
Eye pruritus 14.50 11.05 159 374809 11253 42235114
Hepatic encephalopathy 14.47 11.05 214 374754 16228 42230139
Helicobacter test positive 14.46 11.05 26 374942 798 42245569
Wrong technique in product usage process 14.44 11.05 276 374692 42359 42204008
Hepatitis B 14.36 11.05 23 374945 6688 42239679
Renal failure 14.30 11.05 1459 373509 142267 42104100
Incision site pain 14.30 11.05 43 374925 1860 42244507
Cerebral artery thrombosis 14.28 11.05 33 374935 1216 42245151
Rebound acid hypersecretion 14.24 11.05 10 374958 101 42246266
Acute graft versus host disease 14.20 11.05 32 374936 8183 42238184
Accidental exposure to product 14.18 11.05 113 374855 20280 42226087
Neoplasm progression 14.17 11.05 175 374793 28825 42217542
Rectal prolapse 14.15 11.05 21 374947 547 42245820
Graft versus host disease 14.11 11.05 62 374906 12863 42233504
Oropharyngeal blistering 14.11 11.05 13 374955 199 42246168
Blood pressure increased 14.03 11.05 743 374225 101185 42145182
Pneumococcal sepsis 14.03 11.05 36 374932 1419 42244948
Cardiac septal defect 14.01 11.05 28 374940 932 42245435
Toxic epidermal necrolysis 13.99 11.05 321 374647 26429 42219938
Pancreatic enzyme abnormality 13.92 11.05 10 374958 105 42246262
Angioedema 13.88 11.05 480 374488 41997 42204370
Aspergillus infection 13.86 11.05 82 374886 15755 42230612
Regurgitation 13.80 11.05 43 374925 1897 42244470
Infusion site extravasation 13.77 11.05 89 374879 5392 42240975
Muscular weakness 13.74 11.05 881 374087 82617 42163750
Insurance issue 13.70 11.05 72 374896 4044 42242323
Posterior reversible encephalopathy syndrome 13.70 11.05 62 374906 12759 42233608
Chemotherapeutic drug level increased 13.66 11.05 15 374953 286 42246081
Fracture 13.66 11.05 32 374936 8071 42238296
Nicotine dependence 13.64 11.05 23 374945 670 42245697
Hypogammaglobulinaemia 13.62 11.05 56 374912 11835 42234532
Metastases to liver 13.53 11.05 86 374882 16240 42230127
Drug tolerance 13.50 11.05 6 374962 3284 42243083
Vascular compression 13.50 11.05 17 374951 377 42245990
Aminoaciduria 13.47 11.05 14 374954 250 42246117
Pyloric stenosis 13.46 11.05 27 374941 901 42245466
Infectious crystalline keratopathy 13.45 11.05 8 374960 59 42246308
Drug clearance decreased 13.45 11.05 46 374922 2132 42244235
Intestinal ischaemia 13.44 11.05 134 374834 9254 42237113
Tearfulness 13.42 11.05 7 374961 3493 42242874
Drug level decreased 13.39 11.05 44 374924 9933 42236434
Incorrect dose administered 13.38 11.05 359 374609 52615 42193752
Treatment noncompliance 13.34 11.05 242 374726 37430 42208937
Oedematous pancreatitis 13.34 11.05 24 374944 737 42245630
Suicidal ideation 13.33 11.05 322 374646 47839 42198528
Catheter site extravasation 13.27 11.05 12 374956 179 42246188
Disinhibition 13.24 11.05 9 374959 3886 42242481
Urinary tract discomfort 13.18 11.05 10 374958 115 42246252
Brain abscess 13.14 11.05 11 374957 4273 42242094
Hepatic cytolysis 13.11 11.05 162 374806 26682 42219685
Spontaneous haemorrhage 13.03 11.05 20 374948 537 42245830
Graft versus host disease in skin 13.01 11.05 16 374952 5196 42241171
Systemic infection 12.97 11.05 16 374952 5189 42241178
Eye injury 12.95 11.05 28 374940 986 42245381
Ventricular hyperkinesia 12.83 11.05 13 374955 225 42246142
Urinary tract infection 12.80 11.05 1027 373941 98257 42148110
Oropharyngeal discomfort 12.74 11.05 71 374897 4078 42242289
Traumatic haemorrhage 12.73 11.05 32 374936 1245 42245122
Thrombotic microangiopathy 12.70 11.05 77 374891 14705 42231662
Blood creatinine increased 12.62 11.05 1128 373840 108875 42137492
Abdominal sepsis 12.61 11.05 31 374937 1189 42245178
Skin toxicity 12.60 11.05 24 374944 6525 42239842
Cytomegalovirus colitis 12.49 11.05 10 374958 3971 42242396
Laryngeal discomfort 12.47 11.05 13 374955 233 42246134
Hallucination, auditory 12.47 11.05 78 374890 14786 42231581
Breast inflammation 12.46 11.05 6 374962 27 42246340
Presyncope 12.45 11.05 271 374697 22116 42224251
Gastric xanthoma 12.42 11.05 5 374963 13 42246354
Cerebral infarction 12.41 11.05 196 374772 30973 42215394
Malaise 12.38 11.05 2085 372883 210071 42036296
Disease recurrence 12.37 11.05 185 374783 29493 42216874
Cystitis haemorrhagic 12.31 11.05 29 374939 7300 42239067
Blood copper increased 12.29 11.05 6 374962 28 42246339
Pancreatitis necrotising 12.26 11.05 64 374904 3585 42242782
Arteriosclerotic gangrene 12.24 11.05 8 374960 71 42246296
Latent tetany 12.23 11.05 4 374964 4 42246363
Rhinitis 12.21 11.05 160 374808 11817 42234550
Mesenteric vein thrombosis 12.21 11.05 26 374942 906 42245461
Pulmonary pain 12.19 11.05 36 374932 1542 42244825
Primary hypoparathyroidism 12.19 11.05 7 374961 48 42246319
Hiatus hernia 12.17 11.05 122 374846 8438 42237929
Acute myeloid leukaemia recurrent 12.09 11.05 8 374960 3504 42242863
Cerebral vasoconstriction 12.08 11.05 13 374955 242 42246125
Henoch-Schonlein purpura 12.06 11.05 44 374924 2106 42244261
Alveolitis 12.05 11.05 40 374928 1825 42244542
Vena cava injury 12.04 11.05 15 374953 329 42246038
Hepatic function abnormal 12.03 11.05 562 374406 51005 42195362
Osteoarthritis 12.02 11.05 147 374821 24258 42222109
Pruritus 12.02 11.05 1864 373104 186907 42059460
Pseudoporphyria 11.93 11.05 18 374950 476 42245891
Red blood cell analysis abnormal 11.91 11.05 5 374963 15 42246352
Ectopic gastric mucosa 11.91 11.05 5 374963 15 42246352
Serotonin syndrome 11.87 11.05 158 374810 25687 42220680
Visual acuity reduced 11.86 11.05 98 374870 17452 42228915
Mucosal inflammation 11.85 11.05 337 374631 49037 42197330
Exposure to toxic agent 11.83 11.05 16 374952 4988 42241379
Intestinal infarction 11.82 11.05 20 374948 584 42245783
Injection site haemorrhage 11.80 11.05 58 374910 11678 42234689
Muscle contractions involuntary 11.73 11.05 42 374926 1992 42244375
Lymphadenectomy 11.71 11.05 18 374950 484 42245883
Stoma closure 11.70 11.05 14 374954 294 42246073
Depressive symptom 11.69 11.05 10 374958 3843 42242524
Eosinophilic granulomatosis with polyangiitis 11.66 11.05 38 374930 8600 42237767
Carotid arteriosclerosis 11.66 11.05 46 374922 2286 42244081
Maternal drugs affecting foetus 11.60 11.05 10 374958 3829 42242538
Dysgeusia 11.58 11.05 388 374580 33801 42212566
Vascular anastomotic haemorrhage 11.52 11.05 14 374954 299 42246068
Incarcerated umbilical hernia 11.51 11.05 6 374962 33 42246334
Prostate cancer stage IV 11.47 11.05 4 374964 2536 42243831
Hyperhidrosis 11.46 11.05 935 374033 89577 42156790
Arteriosclerosis coronary artery 11.42 11.05 107 374861 18570 42227797
Drug withdrawal syndrome 11.31 11.05 128 374840 21421 42224946
Blood parathyroid hormone decreased 11.31 11.05 36 374932 1607 42244760
Calciphylaxis 11.28 11.05 29 374939 1144 42245223
Abdominal wall haemorrhage 11.28 11.05 18 374950 500 42245867
Gastric pH decreased 11.25 11.05 11 374957 182 42246185
Blood albumin abnormal 11.23 11.05 16 374952 401 42245966
Radiation inflammation 11.23 11.05 27 374941 1021 42245346
Spinocerebellar disorder 11.23 11.05 3 374965 0 42246367
Sedative therapy 11.23 11.05 3 374965 0 42246367
Product package associated injury 11.23 11.05 3 374965 0 42246367
Catheter site abscess 11.23 11.05 3 374965 0 42246367
Osteolysis 11.22 11.05 9 374959 3571 42242796
Cytokine release syndrome 11.20 11.05 489 374479 44038 42202329
Hand deformity 11.17 11.05 10 374958 3758 42242609
Agitated depression 11.16 11.05 13 374955 265 42246102
Respiratory depression 11.15 11.05 109 374859 18759 42227608
Faeces discoloured 11.13 11.05 211 374757 16803 42229564
Blood sodium decreased 11.13 11.05 223 374745 17939 42228428
Incorrect drug administration rate 11.12 11.05 43 374925 2117 42244250
Obsessive-compulsive disorder 11.07 11.05 27 374941 6716 42239651
Miosis 11.05 11.05 71 374897 13375 42232992

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 3972.64 9.64 4032 760506 90308 109734453
Hypomagnesaemia 1759.41 9.64 2129 762409 58241 109766520
Synovitis 1482.45 9.64 107 764431 273985 109550776
Pemphigus 1311.19 9.64 37 764501 214533 109610228
Hand deformity 1288.18 9.64 51 764487 218455 109606306
Anti-cyclic citrullinated peptide antibody positive 1200.78 9.64 10 764528 181974 109642787
Drug intolerance 1140.28 9.64 700 763838 405812 109418949
Wound 1014.13 9.64 195 764343 234242 109590519
Glossodynia 994.15 9.64 169 764369 221835 109602926
Duodenal ulcer perforation 988.24 9.64 60 764478 177640 109647121
Treatment failure 961.23 9.64 357 764181 276877 109547884
Helicobacter infection 957.90 9.64 80 764458 181797 109642964
Hyponatraemia 946.71 9.64 3482 761056 214171 109610590
Systemic lupus erythematosus 943.48 9.64 292 764246 254046 109570715
Hypocalcaemia 910.06 9.64 1627 762911 63739 109761022
Rheumatoid factor positive 864.73 9.64 8 764530 131632 109693129
Contraindicated product administered 860.14 9.64 320 764218 247947 109576814
Drug ineffective 845.93 9.64 6609 757929 1513931 108310830
Folliculitis 839.79 9.64 90 764448 167563 109657198
Acute kidney injury 818.85 9.64 7325 757213 628105 109196656
Muscle injury 806.33 9.64 40 764498 140767 109683994
Arthropathy 800.49 9.64 499 764039 287023 109537738
White blood cell count decreased 791.01 9.64 3413 761125 225977 109598784
Rheumatic fever 776.44 9.64 14 764524 122565 109702196
Therapeutic product effect decreased 759.88 9.64 369 764169 243947 109580814
Drug interaction 720.05 9.64 5911 758627 494272 109330489
Tubulointerstitial nephritis 712.27 9.64 1317 763221 52967 109771794
C-reactive protein abnormal 711.52 9.64 47 764491 129648 109695113
Pericarditis 706.05 9.64 315 764223 218799 109605962
Joint swelling 701.18 9.64 1242 763296 441603 109383158
Irritable bowel syndrome 688.41 9.64 147 764391 164068 109660693
Hepatic enzyme increased 633.96 9.64 771 763767 320121 109504640
Psoriatic arthropathy 625.91 9.64 288 764250 196473 109628288
Drug hypersensitivity 610.73 9.64 1400 763138 452690 109372071
Rheumatoid arthritis 606.65 9.64 706 763832 298907 109525854
Impaired healing 602.75 9.64 303 764235 196414 109628347
Facet joint syndrome 601.54 9.64 14 764524 96814 109727947
Sleep disorder due to general medical condition, insomnia type 563.04 9.64 44 764494 105599 109719162
Bursitis 557.58 9.64 110 764428 129808 109694953
Swollen joint count increased 536.34 9.64 8 764530 83653 109741108
Type 2 diabetes mellitus 528.12 9.64 283 764255 176949 109647812
Lip dry 513.44 9.64 49 764489 100034 109724727
Breast cancer stage III 509.64 9.64 7 764531 79110 109745651
Fibromyalgia 494.63 9.64 283 764255 170626 109654135
Maternal exposure during pregnancy 482.89 9.64 632 763906 254251 109570510
Joint range of motion decreased 467.82 9.64 131 764407 121701 109703060
Alopecia 452.86 9.64 1172 763366 363581 109461180
Ill-defined disorder 449.25 9.64 263 764275 156590 109668171
Hypokalaemia 448.23 9.64 2464 762074 179984 109644777
Neutrophil count decreased 444.94 9.64 1836 762702 119105 109705656
Stomatitis 444.70 9.64 739 763799 269503 109555258
Infective pulmonary exacerbation of cystic fibrosis 423.77 9.64 517 764021 14254 109810507
Musculoskeletal stiffness 403.82 9.64 829 763709 278993 109545768
Blood cholesterol increased 396.35 9.64 415 764123 184370 109640391
Swelling 390.53 9.64 1189 763349 349852 109474909
Osteoarthritis 382.94 9.64 418 764120 182205 109642556
Hypersensitivity 373.57 9.64 1481 763057 402517 109422244
Peripheral venous disease 369.92 9.64 67 764471 84050 109740711
Deep vein thrombosis postoperative 355.63 9.64 12 764526 59279 109765482
Grip strength decreased 350.11 9.64 65 764473 80109 109744652
Discomfort 337.76 9.64 604 763934 214103 109610658
Wound infection 332.80 9.64 125 764413 96340 109728421
Infusion related reaction 328.91 9.64 1435 763103 379727 109445034
Chronic kidney disease 319.99 9.64 1207 763331 75084 109749677
Nasopharyngitis 315.15 9.64 1527 763011 392834 109431927
Off label use 311.50 9.64 7950 756588 1492235 108332526
Weight increased 308.72 9.64 1672 762866 417972 109406789
Injury 295.01 9.64 481 764057 176784 109647977
Product use issue 293.54 9.64 1134 763404 310561 109514200
Subacute cutaneous lupus erythematosus 283.47 9.64 252 764286 4742 109820019
Granulocyte count decreased 277.75 9.64 226 764312 3748 109821013
Blister 273.35 9.64 742 763796 226634 109598127
Musculoskeletal pain 272.71 9.64 532 764006 182491 109642270
Inflammation 269.04 9.64 584 763954 192654 109632107
Blepharospasm 268.17 9.64 32 764506 54819 109769942
Therapeutic product effect incomplete 263.34 9.64 738 763800 223067 109601694
Live birth 262.50 9.64 77 764461 69407 109755354
Abdominal discomfort 259.87 9.64 1625 762913 392233 109432528
Dislocation of vertebra 258.23 9.64 10 764528 43711 109781050
Autoimmune disorder 257.80 9.64 67 764471 65416 109759345
Adjustment disorder with depressed mood 255.95 9.64 11 764527 43872 109780889
Night sweats 253.86 9.64 332 764206 133651 109691110
Obesity 251.65 9.64 247 764291 113104 109711657
Lower limb fracture 249.46 9.64 104 764434 75244 109749517
Bone erosion 245.15 9.64 20 764518 46351 109778410
Hepatic function abnormal 242.44 9.64 1240 763298 88055 109736706
Hypercholesterolaemia 241.26 9.64 166 764372 90671 109734090
Lung disorder 240.95 9.64 556 763982 179491 109645270
Blood calcium decreased 240.35 9.64 666 763872 35179 109789582
General physical health deterioration 237.62 9.64 1842 762696 423453 109401308
X-ray abnormal 234.86 9.64 6 764532 38111 109786650
Sciatica 232.20 9.64 179 764359 92220 109732541
Vomiting 230.93 9.64 8068 756470 902607 108922154
Prescribed overdose 224.79 9.64 166 764372 87415 109737346
Intentional product use issue 221.29 9.64 921 763617 246985 109577776
Lip swelling 221.13 9.64 812 763726 49855 109774906
Drug abuse 220.00 9.64 570 763968 176841 109647920
Chest discomfort 217.27 9.64 1993 762545 171855 109652906
Nail disorder 213.79 9.64 67 764471 57868 109766893
Road traffic accident 212.98 9.64 257 764281 107141 109717620
Diarrhoea 212.48 9.64 9766 754772 1129739 108695022
Therapy non-responder 203.92 9.64 494 764044 156813 109667948
Onychomadesis 203.76 9.64 35 764503 45628 109779133
Chills 201.60 9.64 2110 762428 188470 109636291
Hereditary angioedema 197.61 9.64 245 764293 6869 109817892
Creatinine renal clearance decreased 195.01 9.64 452 764086 21363 109803398
C-reactive protein 193.98 9.64 3 764535 30328 109794433
Retinitis 192.27 9.64 7 764531 32320 109792441
Orthostatic hypotension 190.44 9.64 935 763603 65314 109759447
Gait inability 189.92 9.64 412 764126 135964 109688797
Exposure during pregnancy 188.93 9.64 563 763975 166861 109657900
Inappropriate antidiuretic hormone secretion 184.16 9.64 584 763954 33267 109791494
Infection 181.25 9.64 1615 762923 360585 109464176
Temperature intolerance 178.62 9.64 335 764203 13615 109811146
Hyperpyrexia 173.35 9.64 245 764293 7824 109816937
Tetany 171.85 9.64 165 764373 3439 109821322
Constipation 170.42 9.64 3445 761093 354341 109470420
Sinusitis 167.00 9.64 1282 763256 295406 109529355
Coeliac disease 166.57 9.64 46 764492 43141 109781620
Exostosis 166.29 9.64 55 764483 45901 109778860
Arthralgia 166.18 9.64 4112 760426 775520 109049241
Wheezing 166.18 9.64 1057 763481 254173 109570588
Platelet count decreased 166.06 9.64 2373 762165 228070 109596691
Breast cancer stage II 162.57 9.64 6 764532 27369 109797392
Pregnancy 161.91 9.64 75 764463 50992 109773769
Adverse event 159.70 9.64 319 764219 108490 109716271
Red blood cell sedimentation rate increased 157.78 9.64 185 764353 78117 109746644
Liver disorder 157.14 9.64 483 764055 141760 109683001
Cognitive disorder 156.85 9.64 1090 763448 86421 109738340
Pulmonary fibrosis 155.99 9.64 292 764246 101750 109723011
Hypotension 155.12 9.64 4729 759809 519120 109305641
Condition aggravated 154.33 9.64 3884 760654 730952 109093809
Hypoparathyroidism 151.19 9.64 107 764431 1423 109823338
Prescribed underdose 149.34 9.64 138 764400 65036 109759725
Drug tolerance decreased 148.05 9.64 11 764527 27529 109797232
Cystic fibrosis 147.89 9.64 173 764365 4558 109820203
Tachypnoea 147.12 9.64 601 763937 38794 109785967
Mobility decreased 147.10 9.64 998 763540 236424 109588337
Gastrointestinal disorder 146.96 9.64 1023 763515 240929 109583832
Red blood cell sedimentation rate abnormal 146.84 9.64 5 764533 24504 109800257
Dyspnoea 146.67 9.64 9190 755348 1097682 108727079
Sedation complication 146.29 9.64 382 764156 19473 109805288
Gastrointestinal haemorrhage 146.18 9.64 1769 762769 163749 109661012
Back injury 145.11 9.64 73 764465 47326 109777435
Nausea 145.11 9.64 10155 754383 1225535 108599226
Completed suicide 139.38 9.64 1041 763497 241340 109583421
Hallucination 138.11 9.64 1185 763353 100247 109724514
Lethargy 137.42 9.64 1112 763426 92464 109732297
Abdominal pain 137.21 9.64 4575 759963 508414 109316347
Balance disorder 135.48 9.64 1316 763222 115244 109709517
Hip arthroplasty 135.36 9.64 112 764426 55701 109769060
Product label confusion 134.56 9.64 5 764533 22672 109802089
Product use in unapproved indication 134.26 9.64 2229 762309 445148 109379613
Anaemia 134.06 9.64 4830 759708 542256 109282505
Pyrexia 132.44 9.64 7530 757008 890735 108934026
Metabolic acidosis 131.49 9.64 1157 763381 98587 109726174
Renal failure 127.95 9.64 2240 762298 224334 109600427
Hypoaesthesia 127.78 9.64 1472 763066 312751 109512010
Dehydration 127.01 9.64 2673 761865 276838 109547923
Cardiospasm 120.57 9.64 160 764378 4807 109819954
Palmoplantar keratoderma 119.35 9.64 166 764372 5221 109819540
Sleep disorder 117.63 9.64 846 763692 197798 109626963
Hyperkalaemia 117.57 9.64 1446 763092 134350 109690411
Liver injury 116.19 9.64 589 763949 149824 109674937
Renal injury 116.01 9.64 338 764200 18375 109806386
Osmotic demyelination syndrome 114.91 9.64 103 764435 1960 109822801
Drug resistance 114.86 9.64 132 764406 56242 109768519
Peripheral swelling 114.11 9.64 2035 762503 401999 109422762
Rhabdomyolysis 113.45 9.64 1303 763235 119098 109705663
Urinary tract infection 113.25 9.64 3006 761532 323276 109501485
Therapeutic response decreased 109.92 9.64 323 764215 96176 109728585
Hypophosphataemia 109.06 9.64 487 764051 32695 109792066
Maternal exposure timing unspecified 108.52 9.64 10 764528 21003 109803758
Agranulocytosis 105.84 9.64 761 763777 60999 109763762
Palpitations 105.05 9.64 1615 762923 157597 109667164
Myalgia 105.04 9.64 2139 762399 220242 109604519
Liver function test abnormal 103.21 9.64 823 763715 68127 109756634
Plasma cell myeloma 103.00 9.64 767 763771 62169 109762592
Hypernatraemia 102.87 9.64 314 764224 17519 109807242
Haemoglobin decreased 101.67 9.64 2343 762195 246384 109578377
Onychomycosis 101.52 9.64 71 764467 38460 109786301
Rheumatoid nodule 101.32 9.64 11 764527 20285 109804476
Pruritus genital 100.72 9.64 170 764368 6352 109818409
Metabolic alkalosis 100.24 9.64 156 764382 5439 109819322
Swollen tongue 100.13 9.64 738 763800 59624 109765137
Sepsis 99.68 9.64 2966 761572 324380 109500381
Syncope 99.61 9.64 1960 762578 200576 109624185
Tinnitus 99.19 9.64 738 763800 59802 109764959
Laryngitis 98.12 9.64 89 764449 42322 109782439
Finger deformity 95.40 9.64 55 764483 33037 109791724
Lower respiratory tract infection 94.51 9.64 1150 763388 241956 109582805
Pain 94.16 9.64 5523 759015 949432 108875329
Blood pressure systolic increased 93.65 9.64 279 764259 82712 109742049
Tremor 93.46 9.64 1939 762599 200293 109624468
Taste disorder 93.13 9.64 195 764343 65192 109759569
Oedema 92.35 9.64 966 763572 209010 109615751
Blood sodium decreased 92.31 9.64 515 764023 37804 109786957
Atrial tachycardia 91.93 9.64 199 764339 8979 109815782
International normalised ratio increased 90.89 9.64 959 763579 85813 109738948
Sleep terror 90.00 9.64 163 764375 6447 109818314
Electrolyte imbalance 89.43 9.64 498 764040 36530 109788231
Liver function test increased 89.26 9.64 313 764225 88235 109736526
Device expulsion 88.12 9.64 52 764486 30839 109793922
Gastric pH decreased 88.08 9.64 66 764472 964 109823797
Muscle twitching 87.82 9.64 425 764113 29510 109795251
Toxic epidermal necrolysis 87.60 9.64 682 763856 56045 109768716
C-reactive protein increased 87.33 9.64 1024 763514 216895 109607866
Knee arthroplasty 87.30 9.64 200 764338 64748 109760013
Porphyria acute 86.92 9.64 13 764525 18767 109805994
Foot deformity 86.90 9.64 125 764413 48355 109776406
Blood magnesium decreased 86.85 9.64 320 764218 19676 109805085
Gastric polyps 86.67 9.64 145 764393 5378 109819383
Tension headache 85.65 9.64 199 764339 9419 109815342
Adverse reaction 84.16 9.64 50 764488 29544 109795217
Neutrophil count increased 83.66 9.64 466 764072 34186 109790575
Injection site reaction 83.13 9.64 325 764213 88745 109736016
Therapy partial responder 83.12 9.64 80 764458 36981 109787780
Swelling face 82.92 9.64 990 763548 91331 109733430
Atrial fibrillation 82.33 9.64 2125 762413 227517 109597244
Blood creatinine increased 81.41 9.64 1744 762794 181145 109643616
Upper gastrointestinal haemorrhage 81.11 9.64 609 763929 49487 109775274
Hyperhidrosis 79.22 9.64 1773 762765 185525 109639236
Dry mouth 79.17 9.64 942 763596 199006 109625755
Haematemesis 79.11 9.64 688 763850 58420 109766341
Renal impairment 78.49 9.64 1780 762758 186665 109638096
Neutropenic sepsis 77.94 9.64 419 764119 30327 109794434
Seizure 77.92 9.64 2042 762496 219143 109605618
Blood pressure systolic abnormal 76.48 9.64 38 764500 24812 109799949
Blood urea increased 75.82 9.64 644 763894 54313 109770448
Gastritis 75.54 9.64 632 763906 53067 109771694
Blood pressure diastolic abnormal 74.28 9.64 43 764495 25772 109798989
Pancreatitis acute 74.23 9.64 689 763849 59585 109765176
Cytokine release syndrome 74.09 9.64 778 763760 69528 109755233
Urticaria 73.75 9.64 1660 762878 317197 109507564
Immunisation 73.40 9.64 100 764438 3083 109821678
Angioedema 72.77 9.64 1019 763519 97481 109727280
End stage renal disease 72.72 9.64 318 764220 21155 109803606
Blood pressure fluctuation 71.78 9.64 270 764268 74554 109750207
Tenosynovitis 71.51 9.64 13 764525 16270 109808491
Disorganised speech 69.06 9.64 99 764439 3204 109821557
Pulmonary embolism 68.17 9.64 1954 762584 212520 109612241
Circulatory collapse 68.12 9.64 520 764018 42473 109782288
Carotid artery occlusion 67.39 9.64 181 764357 9384 109815377
Cyanosis 67.23 9.64 393 764145 29348 109795413
Subarachnoid haemorrhage 66.83 9.64 392 764146 29310 109795451
Loss of personal independence in daily activities 65.61 9.64 691 763847 149329 109675432
Arthritis 65.02 9.64 793 763745 166793 109657968
Mouth ulceration 64.78 9.64 561 763977 47577 109777184
Drug use disorder 64.75 9.64 22 764516 18052 109806709
Tachycardia 64.52 9.64 2037 762501 224608 109600153
Seronegative arthritis 63.64 9.64 8 764530 13169 109811592
Agitation 63.53 9.64 1117 763421 111934 109712827
Facial pain 62.90 9.64 241 764297 15098 109809663
Walking aid user 62.45 9.64 49 764489 25026 109799735
Impaired quality of life 62.35 9.64 388 764150 29629 109795132
Joint stiffness 62.34 9.64 246 764292 66997 109757764
Enthesopathy 61.69 9.64 7 764531 12471 109812290
Labelled drug-drug interaction medication error 61.01 9.64 379 764159 28923 109795838
Fall 60.78 9.64 4902 759636 598580 109226181
Eosinophilic oesophagitis 60.55 9.64 59 764479 1253 109823508
Suicide attempt 60.38 9.64 442 764096 102952 109721809
Hypertension 60.10 9.64 2897 761641 507187 109317574
Electrocardiogram QT prolonged 59.95 9.64 1073 763465 107887 109716874
Anosmia 59.65 9.64 206 764332 12266 109812495
Contusion 59.45 9.64 1196 763342 232165 109592596
Haemarthrosis 59.19 9.64 146 764392 7183 109817578
Hypoglycaemia 58.55 9.64 1128 763410 114976 109709785
Drug tolerance 58.02 9.64 21 764517 16564 109808197
Dizziness 57.62 9.64 5589 758949 692604 109132157
Drug level increased 57.02 9.64 542 763996 47177 109777584
Osteoporosis 56.63 9.64 361 764177 86791 109737970
Ventricular tachycardia 56.32 9.64 561 763977 49448 109775313
Drug ineffective for unapproved indication 56.11 9.64 448 764090 102390 109722371
Ventricular fibrillation 55.87 9.64 482 764056 40831 109783930
Jaundice 54.86 9.64 639 763899 58597 109766164
Cough 54.71 9.64 3799 760739 457842 109366919
Muscle spasticity 54.68 9.64 103 764435 35812 109788949
Transient ischaemic attack 54.36 9.64 679 763859 63303 109761458
Pallor 54.03 9.64 613 763925 55854 109768907
Chromaturia 53.95 9.64 368 764170 28992 109795769
Malignant neoplasm progression 53.18 9.64 867 763671 173700 109651061
Depressed level of consciousness 52.33 9.64 1078 763460 111200 109713561
Hepatic cirrhosis 51.54 9.64 266 764272 67360 109757401
Disorientation 50.95 9.64 728 763810 69943 109754818
Vision blurred 50.71 9.64 1209 763329 127813 109696948
Oesophagitis 50.46 9.64 356 764182 28359 109796402
Infusion site reaction 50.10 9.64 30 764508 17652 109807109
Abnormal loss of weight 49.56 9.64 170 764368 10087 109814674
Normal newborn 49.41 9.64 47 764491 21849 109802912
Multiple-drug resistance 49.38 9.64 15 764523 13220 109811541
Renal tubular acidosis 49.26 9.64 104 764434 4611 109820150
Adverse drug reaction 49.14 9.64 479 764059 105080 109719681
Rectal haemorrhage 48.35 9.64 1127 763411 118706 109706055
Haematuria 48.02 9.64 824 763714 82181 109742580
Lymphocyte count decreased 48 9.64 606 763932 56637 109768124
Alanine aminotransferase increased 47.99 9.64 1635 762903 182138 109642623
Asthenia 47.87 9.64 5452 759086 683547 109141214
Ovarian hyperstimulation syndrome 47.84 9.64 111 764427 5249 109819512
Hypertrichosis 47.42 9.64 60 764478 1718 109823043
Dysphagia 47.31 9.64 1394 763144 152206 109672555
Hyponatraemic encephalopathy 46.83 9.64 31 764507 367 109824394
Product quality issue 46.81 9.64 327 764211 76972 109747789
Flushing 46.66 9.64 999 763539 103737 109721024
Acidosis 46.65 9.64 291 764247 22240 109802521
Blood alkaline phosphatase increased 46.55 9.64 719 763819 70216 109754545
Device difficult to use 46.51 9.64 37 764501 18768 109805993
Acidosis hyperchloraemic 46.28 9.64 56 764482 1530 109823231
Back pain 46.04 9.64 3065 761473 367931 109456830
Granulocytopenia 45.91 9.64 192 764346 12523 109812238
Disability 45.73 9.64 87 764451 30136 109794625
COVID-19 45.67 9.64 2102 762436 242958 109581803
Joint destruction 45.42 9.64 10 764528 10933 109813828
Immune reconstitution inflammatory syndrome 45.32 9.64 28 764510 16198 109808563
Full blood count decreased 45.26 9.64 378 764160 31721 109793040
Urinary retention 45.23 9.64 705 763833 68978 109755783
Rapid correction of hyponatraemia 45.17 9.64 25 764513 208 109824553
Panniculitis 44.77 9.64 26 764512 15556 109809205
Paraesthesia oral 44.58 9.64 391 764147 33280 109791481
Discoloured vomit 44.45 9.64 62 764476 1955 109822806
Illness 44.43 9.64 807 763731 81364 109743397
Faeces discoloured 44.31 9.64 393 764145 33555 109791206
Presyncope 44.22 9.64 525 764013 48362 109776399
Toxicity to various agents 44.08 9.64 2797 761741 477758 109347003
Rash papular 43.62 9.64 334 764204 27305 109797456
Temperature regulation disorder 43.59 9.64 17 764521 12809 109811952
Feeling of despair 43.48 9.64 87 764451 3711 109821050
Rash 43.36 9.64 4991 759547 815973 109008788
Respiratory failure 42.97 9.64 1860 762678 213472 109611289
Acute respiratory failure 42.77 9.64 745 763793 74515 109750246
Hiatus hernia 42.68 9.64 332 764206 27274 109797487
Dysphoria 42.66 9.64 119 764419 6309 109818452
Overlap syndrome 42.56 9.64 6 764532 9053 109815708
Product preparation issue 42.34 9.64 72 764466 2707 109822054
Parosmia 42.23 9.64 192 764346 12988 109811773
Unresponsive to stimuli 42.02 9.64 647 763891 63143 109761618
Abdominal distension 41.80 9.64 1542 762996 173561 109651200
Cogwheel rigidity 41.49 9.64 84 764454 3614 109821147
Subcutaneous drug absorption impaired 41.34 9.64 3 764535 7656 109817105
Blood potassium decreased 41.25 9.64 563 763975 53551 109771210
Mania 40.83 9.64 265 764273 20531 109804230
Depersonalisation/derealisation disorder 40.74 9.64 62 764476 2119 109822642
Heart rate increased 40.72 9.64 1292 763246 142542 109682219
Pulmonary pain 40.29 9.64 115 764423 6178 109818583
Chronic obstructive pulmonary disease 39.94 9.64 1013 763525 108145 109716616
Sopor 39.70 9.64 125 764413 36421 109788340
Drug dose omission by device 39.24 9.64 26 764512 14490 109810271
Product dose omission issue 39.13 9.64 2654 761884 319128 109505633
Substance use disorder 38.94 9.64 3 764535 7287 109817474
Sedation 38.25 9.64 686 763852 68997 109755764
Atrioventricular block first degree 38.22 9.64 197 764341 14028 109810733
Pain of skin 37.97 9.64 253 764285 19776 109804985
Lupus-like syndrome 37.96 9.64 149 764389 40643 109784118
Obstructive airways disorder 37.77 9.64 177 764361 45972 109778789
Deep vein thrombosis 37.65 9.64 1249 763289 138638 109686123
Respiratory tract infection 37.55 9.64 700 763838 70917 109753844
Disturbance in attention 37.53 9.64 620 763918 61375 109763386
Pneumonitis 37.39 9.64 740 763798 75791 109748970
Asthma 37.32 9.64 1384 763154 248907 109575854
Eye pruritus 37.07 9.64 368 764170 32407 109792354
Multimorbidity 36.95 9.64 49 764489 1471 109823290
Dysgeusia 36.68 9.64 684 763854 69301 109755460
Stevens-Johnson syndrome 36.59 9.64 490 764048 46411 109778350
Gastric mucosal hypertrophy 36.52 9.64 25 764513 314 109824447
Blood fibrinogen decreased 36.46 9.64 66 764472 2609 109822152
Burning sensation 36.46 9.64 677 763861 68535 109756226
Coagulation time prolonged 36.05 9.64 69 764469 2848 109821913
Ulcer haemorrhage 35.91 9.64 63 764475 22508 109802253
Post transplant lymphoproliferative disorder 35.84 9.64 33 764505 15580 109809181
Hepatic encephalopathy 35.80 9.64 325 764213 27931 109796830
Spinal muscular atrophy 35.71 9.64 27 764511 400 109824361
Eosinophil count 35.68 9.64 20 764518 171 109824590
Derealisation 35.67 9.64 58 764480 2100 109822661
Bicytopenia 35.66 9.64 115 764423 6609 109818152
Hypoaesthesia oral 35.45 9.64 220 764318 16782 109807979
Insulin autoimmune syndrome 35.44 9.64 34 764504 708 109824053
Catatonia 35.20 9.64 17 764521 11283 109813478
Hypoparathyroidism secondary 35.20 9.64 23 764515 266 109824495
Pneumonia 35.19 9.64 6723 757815 869991 108954770
Melaena 35.00 9.64 669 763869 68088 109756673
Poisoning 34.92 9.64 95 764443 29010 109795751
General symptom 34.91 9.64 9 764529 8837 109815924
Blood pressure diastolic decreased 34.73 9.64 129 764409 35756 109789005
Neuritis 34.53 9.64 5 764533 7394 109817367
Blood phosphorus increased 34.43 9.64 212 764326 16128 109808633
Blood immunoglobulin E increased 34.41 9.64 122 764416 7360 109817401
Pathogen resistance 34.27 9.64 43 764495 17629 109807132
Drug clearance decreased 34.23 9.64 83 764455 4039 109820722
Polyuria 34.20 9.64 225 764313 17513 109807248
Underdose 34.14 9.64 278 764260 63276 109761485
Product formulation issue 33.98 9.64 44 764494 1290 109823471
Mouth swelling 33.90 9.64 120 764418 7234 109817527
Laryngeal discomfort 33.89 9.64 34 764504 749 109824012
Blood potassium increased 33.66 9.64 365 764173 32884 109791877
Feeling abnormal 33.65 9.64 1550 762988 179161 109645600
Pulmonary malformation 33.56 9.64 21 764517 224 109824537
Neck pain 33.49 9.64 624 763914 122506 109702255
Hypochloraemia 33.48 9.64 76 764462 3542 109821219
Loss of consciousness 33.02 9.64 1667 762871 194639 109630122
Sensitisation 32.79 9.64 82 764456 4069 109820692
Coagulopathy 32.57 9.64 429 764109 40482 109784279
Spondylitis 32.46 9.64 19 764519 11319 109813442
Breast cancer stage I 32.22 9.64 6 764532 7381 109817380
Migraine 32.04 9.64 922 763616 170730 109654031
Hallucinations, mixed 31.96 9.64 132 764406 8561 109816200
Bone marrow failure 31.93 9.64 570 763968 57278 109767483
Human herpesvirus 6 infection 31.77 9.64 4 764534 6577 109818184
Hypophagia 31.74 9.64 526 764012 52100 109772661
Intestinal ischaemia 31.66 9.64 206 764332 15973 109808788
Hyperchloraemia 31.59 9.64 42 764496 1264 109823497
Mucormycosis 31.59 9.64 17 764521 10611 109814150
Laryngeal oedema 31.52 9.64 143 764395 9664 109815097
Throat tightness 31.34 9.64 362 764176 33127 109791634
Diverticulum intestinal 31.28 9.64 162 764376 11557 109813204
Ascites 31.27 9.64 852 763686 91956 109732805
Genital ulceration 31.19 9.64 52 764486 1923 109822838
Hypervolaemia 31.19 9.64 498 764040 48962 109775799
Foetal death 31.16 9.64 39 764499 16006 109808755
Clostridium difficile infection 31.06 9.64 520 764018 51609 109773152
Blood glucose increased 30.94 9.64 1164 763374 131332 109693429
Rash macular 30.94 9.64 406 764132 38280 109786481
Tongue oedema 30.86 9.64 126 764412 8130 109816631
Drooling 30.80 9.64 114 764424 7025 109817736
Immunosuppressant drug level increased 30.55 9.64 161 764377 11563 109813198
Joint dislocation 30.48 9.64 127 764411 34063 109790698
Right hemisphere deficit syndrome 30.37 9.64 10 764528 16 109824745
Mycotic allergy 30.31 9.64 3 764535 5951 109818810
Asthma-chronic obstructive pulmonary disease overlap syndrome 30.28 9.64 4 764534 6340 109818421
Genital blister 30.18 9.64 19 764519 205 109824556
Blood bilirubin increased 30.18 9.64 713 763825 75259 109749502
Urine output decreased 30.15 9.64 238 764300 19638 109805123
Blindness 30.09 9.64 384 764154 35975 109788786
Epstein-Barr virus infection 30.08 9.64 52 764486 18686 109806075
Superinfection 30.05 9.64 98 764440 5665 109819096
Immunodeficiency 30.03 9.64 152 764386 38686 109786075
Eructation 30.01 9.64 183 764355 13874 109810887
Malignant mediastinal neoplasm 29.84 9.64 42 764496 1336 109823425
Metastases to lymph nodes 29.76 9.64 36 764502 14996 109809765
Abdominal tenderness 29.72 9.64 167 764371 12290 109812471
Colitis 29.72 9.64 922 763616 101401 109723360
Hypopnoea 29.47 9.64 156 764382 11224 109813537
Ear pain 29.43 9.64 231 764307 52995 109771766
Poisoning deliberate 29.36 9.64 89 764449 26242 109798519
Long QT syndrome 29.32 9.64 112 764426 7006 109817755
Administration site extravasation 29.30 9.64 47 764491 1682 109823079
Hepatitis cholestatic 29.26 9.64 215 764323 17351 109807410
Muscle rigidity 29.23 9.64 274 764264 23757 109801004
Product packaging confusion 29.05 9.64 23 764515 366 109824395
Parkinsonism 29.04 9.64 257 764281 21930 109802831
Skin discolouration 28.77 9.64 488 764050 48558 109776203
Faecaloma 28.68 9.64 189 764349 14719 109810042
Palatal oedema 28.52 9.64 46 764492 1654 109823107
Burning mouth syndrome 28.43 9.64 29 764509 652 109824109
Sputum increased 28.39 9.64 96 764442 5655 109819106
Catarrh 28.26 9.64 113 764425 7222 109817539
Epistaxis 28.01 9.64 1135 763403 129237 109695524
Substance abuse 27.83 9.64 27 764511 12436 109812325
Suffocation feeling 27.75 9.64 51 764487 2040 109822721
Indifference 27.74 9.64 22 764516 351 109824410
Feeling of body temperature change 27.69 9.64 100 764438 6088 109818673
Bradycardia 27.69 9.64 1328 763210 154189 109670572
Occupational dermatitis 27.58 9.64 16 764522 147 109824614
Cross sensitivity reaction 27.54 9.64 93 764445 5474 109819287
H1N1 influenza 27.49 9.64 63 764475 2955 109821806
Polyarthritis 27.47 9.64 56 764482 18907 109805854
Exposure to toxic agent 27.41 9.64 29 764509 12829 109811932
Arrhythmia 27.35 9.64 652 763886 68923 109755838
Heart rate decreased 27.23 9.64 405 764133 82351 109742410
Body temperature decreased 27.18 9.64 147 764391 36788 109787973
Hypoalbuminaemia 27.02 9.64 313 764225 28661 109796100
Vascular device infection 26.88 9.64 201 764337 16311 109808450
Nephrogenic anaemia 26.78 9.64 81 764457 4496 109820265
Lung consolidation 26.71 9.64 143 764395 10333 109814428
Wall motion score index abnormal 26.70 9.64 31 764507 810 109823951
Odynophagia 26.66 9.64 178 764360 13923 109810838
Progressive multifocal leukoencephalopathy 26.66 9.64 86 764452 24870 109799891
Cerebellar syndrome 26.66 9.64 100 764438 6202 109818559
Restless legs syndrome 26.64 9.64 274 764264 24352 109800409
Insomnia 26.63 9.64 2138 762400 358452 109466309
Cystic fibrosis respiratory infection suppression 26.42 9.64 24 764514 465 109824296
Gamma-glutamyltransferase increased 26.41 9.64 582 763956 60727 109764034
Blood creatine phosphokinase increased 26.39 9.64 677 763861 72400 109752361
Blood phosphorus decreased 26.33 9.64 114 764424 7551 109817210
Coma 26.27 9.64 617 763921 117252 109707509
Cytomegalovirus viraemia 26.12 9.64 52 764486 17712 109807049
Oliguria 25.93 9.64 219 764319 18438 109806323
Dust allergy 25.91 9.64 5 764533 5996 109818765
Monocyte chemotactic protein-1 increased 25.87 9.64 21 764517 347 109824414
Type I hypersensitivity 25.85 9.64 100 764438 6293 109818468
Insurance issue 25.81 9.64 143 764395 10469 109814292
Diplopia 25.74 9.64 420 764118 41474 109783287
Dermatitis allergic 25.58 9.64 246 764292 21478 109803283
Iron deficiency anaemia 25.57 9.64 332 764206 31227 109793534
Unintentional medical device removal 25.48 9.64 15 764523 8908 109815853
Oedematous pancreatitis 25.39 9.64 43 764495 1611 109823150
Burns second degree 25.04 9.64 113 764425 7620 109817141
Cytomegalovirus infection reactivation 25.00 9.64 56 764482 18277 109806484
Device use error 24.95 9.64 16 764522 9073 109815688
Amyloid arthropathy 24.90 9.64 43 764495 1637 109823124
Amylase increased 24.87 9.64 160 764378 12359 109812402
Choluria 24.85 9.64 23 764515 457 109824304
Respiratory disorder 24.65 9.64 346 764192 71036 109753725
Granuloma annulare 24.64 9.64 30 764508 825 109823936
Polycystic ovaries 24.51 9.64 81 764457 4715 109820046
Pancreatic abscess 24.49 9.64 16 764522 185 109824576
Hypocholesterolaemia 24.46 9.64 7 764531 6414 109818347
Swelling of eyelid 24.44 9.64 101 764437 6552 109818209
Pulmonary function test decreased 24.43 9.64 122 764416 8578 109816183
Oral pain 24.36 9.64 379 764159 37065 109787696
Muscle disorder 24.29 9.64 101 764437 6571 109818190
Suspected product contamination 24.25 9.64 18 764520 259 109824502
Pain in extremity 24.18 9.64 2973 761565 484145 109340616
Vitamin B12 deficiency 24.12 9.64 135 764403 9920 109814841
Renal cyst haemorrhage 24.07 9.64 28 764510 733 109824028
Sarcoidosis 23.99 9.64 31 764507 12548 109812213
Ejection fraction abnormal 23.90 9.64 65 764473 3395 109821366
Hypochromasia 23.88 9.64 27 764511 685 109824076
Abortion spontaneous 23.84 9.64 139 764399 34143 109790618
Alpha tumour necrosis factor increased 23.80 9.64 21 764517 391 109824370
Incision site pain 23.80 9.64 61 764477 3074 109821687
Aplastic anaemia 23.78 9.64 87 764451 24221 109800540
Hepatic failure 23.72 9.64 633 763905 68106 109756655
Hypoxia 23.70 9.64 1109 763429 128406 109696355
Central nervous system mass 23.61 9.64 29 764509 805 109823956
Pulmonary vasculitis 23.47 9.64 8 764530 6552 109818209
Disease complication 23.44 9.64 91 764447 5736 109819025
Haemorrhage 23.42 9.64 931 763607 105761 109719000
Flatulence 23.41 9.64 498 764040 51651 109773110
Dry skin 23.31 9.64 938 763600 106715 109718046
Supraventricular tachycardia 23.30 9.64 265 764273 24157 109800604
Adjusted calcium decreased 23.17 9.64 17 764521 240 109824521
Lymphatic fistula 23.13 9.64 39 764499 1456 109823305
Dementia 23.12 9.64 327 764211 31346 109793415
Nephropathy 23.10 9.64 166 764372 13301 109811460
Bladder cancer 23.05 9.64 68 764470 20224 109804537
Jejunal ulcer perforation 23.01 9.64 13 764525 113 109824648
Oral candidiasis 22.95 9.64 436 764102 44324 109780437
Cerebral haematoma 22.90 9.64 129 764409 9503 109815258
Blood pressure diastolic increased 22.86 9.64 61 764477 18746 109806015
Product substitution issue 22.81 9.64 252 764286 22809 109801952
Wound infection pseudomonas 22.70 9.64 51 764487 2360 109822401
Renal disorder 22.70 9.64 474 764064 49005 109775756
Anal incontinence 22.64 9.64 242 764296 21722 109803039
Second primary malignancy 22.42 9.64 58 764480 18010 109806751
Duodenitis 22.42 9.64 124 764414 9072 109815689
Pharyngeal swelling 22.22 9.64 151 764387 11881 109812880
Infusion site extravasation 22.08 9.64 147 764391 11487 109813274
Anaphylactic reaction 22.06 9.64 984 763554 113316 109711445
Diffuse large B-cell lymphoma recurrent 21.99 9.64 8 764530 6291 109818470
Hypergammaglobulinaemia 21.94 9.64 30 764508 928 109823833
Incontinence 21.93 9.64 193 764345 16442 109808319
Ejection fraction 21.92 9.64 57 764481 2898 109821863
Haemorrhage intracranial 21.92 9.64 301 764237 28668 109796093
Infusion site pain 21.89 9.64 200 764338 17219 109807542
Atopy 21.83 9.64 33 764505 1121 109823640
Food allergy 21.83 9.64 68 764470 19880 109804881
Oropharyngeal discomfort 21.77 9.64 134 764404 10193 109814568
Hyperparathyroidism secondary 21.76 9.64 61 764477 3243 109821518
Malabsorption 21.64 9.64 95 764443 6330 109818431
Blood albumin decreased 21.61 9.64 289 764249 27363 109797398
Femoral hernia incarcerated 21.56 9.64 38 764500 1471 109823290
Bleeding time prolonged 21.53 9.64 35 764503 1267 109823494
Duodenal stenosis 21.49 9.64 30 764508 947 109823814
Initial insomnia 21.39 9.64 134 764404 10255 109814506
Aspartate aminotransferase increased 21.39 9.64 1330 763208 158606 109666155
Transaminases increased 21.37 9.64 582 763956 62808 109761953
Myoclonic dystonia 21.34 9.64 11 764527 78 109824683
Ear infection 21.33 9.64 305 764233 62427 109762334
Occult blood positive 21.33 9.64 105 764433 7340 109817421
Blood gastrin increased 21.33 9.64 10 764528 56 109824705
Haemoptysis 21.26 9.64 645 763893 70709 109754052
Hyperreflexia 21.22 9.64 125 764413 9360 109815401
Hyperglycaemia 21.19 9.64 753 763785 84337 109740424
Accidental exposure to product 21.19 9.64 232 764306 49776 109774985
Tetanus 21.19 9.64 10 764528 57 109824704
Blood pressure decreased 21.17 9.64 986 763552 114105 109710656
Epiploic appendagitis 21.13 9.64 14 764524 166 109824595
Nightmare 21.12 9.64 382 764156 38481 109786280
Therapeutic response shortened 21.08 9.64 119 764419 29464 109795297
Torsade de pointes 21.01 9.64 244 764294 22356 109802405
Haematotoxicity 20.92 9.64 75 764463 21007 109803754
Airway remodelling 20.83 9.64 29 764509 913 109823848
Depression 20.82 9.64 1899 762639 315436 109509325
Rhinitis 20.78 9.64 243 764295 22302 109802459
Device dislocation 20.76 9.64 131 764407 31573 109793188
Gastrointestinal mucosal exfoliation 20.61 9.64 16 764522 247 109824514
Atrioventricular block complete 20.58 9.64 221 764317 19861 109804900
Graft versus host disease in gastrointestinal tract 20.53 9.64 19 764519 8949 109815812
Pulmonary toxicity 20.49 9.64 59 764479 17687 109807074
BK virus infection 20.47 9.64 37 764501 13069 109811692
Polyomavirus-associated nephropathy 20.46 9.64 16 764522 8185 109816576
Brain scan abnormal 20.45 9.64 38 764500 1533 109823228
Endophthalmitis 20.39 9.64 16 764522 8171 109816590
Intentional overdose 20.34 9.64 730 763808 131771 109692990
Blood electrolytes abnormal 20.31 9.64 45 764493 2063 109822698
Vascular compression 20.27 9.64 26 764512 755 109824006
Personality disorder 20.27 9.64 36 764502 12801 109811960
Cerebrovascular accident 20.25 9.64 1485 763053 179799 109644962
Anaphylactic shock 20.24 9.64 483 764055 51063 109773698
Dilatation intrahepatic duct acquired 20.22 9.64 27 764511 816 109823945
Oesophageal perforation 20.20 9.64 39 764499 1620 109823141
Rebound acid hypersecretion 20.17 9.64 12 764526 116 109824645
Intercepted product preparation error 20.14 9.64 11 764527 6809 109817952
Infective exacerbation of chronic obstructive airways disease 20.14 9.64 58 764480 3132 109821629
Anaphylactoid reaction 20.08 9.64 97 764441 6729 109818032
Haemodialysis 20.06 9.64 199 764339 17520 109807241
Malaise 20.02 9.64 5081 759457 666738 109158023
Cardiac septal defect 19.92 9.64 29 764509 952 109823809
Soft tissue mass 19.86 9.64 37 764501 1496 109823265
Calcium deficiency 19.85 9.64 32 764506 1150 109823611
COVID-19 treatment 19.85 9.64 20 764518 443 109824318
Caesarean section 19.85 9.64 41 764497 13776 109810985
Incorrect product formulation administered 19.80 9.64 15 764523 223 109824538
Malignant spinal cord compression 19.70 9.64 13 764525 153 109824608
Pseudoporphyria 19.70 9.64 26 764512 777 109823984
Degenerative mitral valve disease 19.65 9.64 17 764521 308 109824453
Drug dependence 19.65 9.64 236 764302 49784 109774977
Hypomania 19.64 9.64 25 764513 10185 109814576
Interleukin level increased 19.61 9.64 38 764500 1583 109823178
Faecal calprotectin increased 19.61 9.64 11 764527 6708 109818053
Ectopic gastric mucosa 19.59 9.64 8 764530 30 109824731
Leukocytosis 19.53 9.64 499 764039 53329 109771432
Vertigo 19.52 9.64 760 763778 86110 109738651
Cytomegalovirus infection 19.48 9.64 262 764276 54182 109770579
Deformity 19.42 9.64 25 764513 10135 109814626
Cardiac arrest 19.38 9.64 1596 762942 195157 109629604
Tension 19.38 9.64 78 764460 5000 109819761
Injection site bruising 19.33 9.64 244 764294 51019 109773742
Spirometry abnormal 19.16 9.64 7 764531 5490 109819271
Feeling cold 19.15 9.64 336 764202 33651 109791110
Calciphylaxis 19.02 9.64 68 764470 4119 109820642
Facial discomfort 18.99 9.64 18 764520 369 109824392
Gingival pain 18.93 9.64 179 764359 15557 109809204
Pulmonary hypertension 18.90 9.64 508 764030 54712 109770049
Anuria 18.86 9.64 254 764284 24087 109800674
Cerebral artery thrombosis 18.85 9.64 38 764500 1630 109823131
Regurgitation 18.84 9.64 60 764478 3425 109821336
Nasal oedema 18.83 9.64 12 764526 6827 109817934
Oesophageal atresia 18.78 9.64 11 764527 103 109824658
Hallucination, visual 18.69 9.64 381 764157 39224 109785537
Cholecystitis chronic 18.62 9.64 121 764417 9379 109815382
Metastases to lung 18.55 9.64 89 764449 22974 109801787
Retching 18.54 9.64 239 764299 22443 109802318
Traumatic haemorrhage 18.49 9.64 40 764498 1804 109822957
Sexual dysfunction 18.45 9.64 19 764519 8511 109816250
Blood chromogranin A increased 18.39 9.64 24 764514 709 109824052
Dermatitis atopic 18.36 9.64 263 764275 25278 109799483
Maternal exposure before pregnancy 18.34 9.64 14 764524 7251 109817510
Dialysis 18.32 9.64 212 764326 19407 109805354
Hypergastrinaemia 18.32 9.64 17 764521 339 109824422
Product blister packaging issue 18.23 9.64 17 764521 341 109824420
Lung cyst 18.21 9.64 20 764518 491 109824270
Inflammatory marker increased 18.12 9.64 166 764372 14303 109810458
Blood sodium increased 18.10 9.64 81 764457 5442 109819319
Oesophageal adenocarcinoma 18.10 9.64 28 764510 971 109823790
Overdose 18.06 9.64 1381 763157 232413 109592348
Abdominal sepsis 18.06 9.64 46 764492 2309 109822452
Rash erythematous 17.94 9.64 714 763824 81118 109743643
Urine output increased 17.92 9.64 51 764487 2735 109822026
Steroid dependence 17.92 9.64 110 764428 8359 109816402
Haemodialysis complication 17.80 9.64 17 764521 352 109824409
Dysbiosis 17.78 9.64 43 764495 2089 109822672
Abnormal weight gain 17.77 9.64 60 764478 3531 109821230
Muscle haemorrhage 17.68 9.64 94 764444 6775 109817986
Pancreatic steatosis 17.67 9.64 39 764499 1783 109822978
Mite allergy 17.67 9.64 9 764529 5794 109818967
Urinary tract infection pseudomonal 17.67 9.64 44 764494 2178 109822583
Agitated depression 17.58 9.64 21 764517 566 109824195
Muscle contractions involuntary 17.55 9.64 69 764469 4375 109820386
Multiple drug therapy 17.53 9.64 105 764433 7909 109816852
Gingival bleeding 17.48 9.64 212 764326 19627 109805134
Psoriasis 17.46 9.64 790 763748 139203 109685558
Moraxella test positive 17.40 9.64 7 764531 25 109824736
Photopsia 17.35 9.64 87 764451 6127 109818634
Glomerular filtration rate decreased 17.31 9.64 289 764249 28667 109796094
Use of accessory respiratory muscles 17.28 9.64 23 764515 693 109824068
Nephritis 17.27 9.64 86 764452 6040 109818721
Rhinovirus infection 17.25 9.64 140 764398 11649 109813112
Drug effective for unapproved indication 17.18 9.64 46 764492 14121 109810640
Aortic arteriosclerosis 17.16 9.64 132 764406 10806 109813955
Henoch-Schonlein purpura 17.14 9.64 60 764478 3597 109821164
Chronic sinusitis 17.13 9.64 256 764282 24828 109799933
Seroma 17.09 9.64 56 764482 3245 109821516
Eyelid oedema 17.08 9.64 171 764367 15091 109809670
Motor neurone disease 17.08 9.64 23 764515 701 109824060
Blood creatine increased 16.95 9.64 137 764401 11384 109813377
Poor sucking reflex 16.92 9.64 11 764527 126 109824635
Oropharyngeal blistering 16.91 9.64 26 764512 897 109823864
Endoscopy abnormal 16.89 9.64 8 764530 46 109824715
Carotid arteriosclerosis 16.86 9.64 53 764485 3004 109821757
Ventilation perfusion mismatch 16.83 9.64 24 764514 773 109823988
Oropharyngeal pain 16.82 9.64 1118 763420 134158 109690603
Urine osmolarity increased 16.75 9.64 15 764523 285 109824476
Polyneuropathy 16.75 9.64 141 764397 31871 109792890
Erythema multiforme 16.70 9.64 221 764317 20876 109803885
Hyperphosphataemia 16.66 9.64 180 764358 16201 109808560
Emotional disorder 16.63 9.64 178 764360 15982 109808779
Eosinophil count decreased 16.63 9.64 84 764454 5934 109818827
Cystic fibrosis lung 16.62 9.64 12 764526 165 109824596
Gastroenteritis 16.61 9.64 368 764170 38432 109786329
Injection site warmth 16.56 9.64 63 764475 17342 109807419
Pulmonary oedema 16.55 9.64 853 763685 99806 109724955
Viral mutation identified 16.50 9.64 5 764533 4414 109820347
Ageusia 16.48 9.64 208 764330 19437 109805324
Urine calcium decreased 16.42 9.64 7 764531 30 109824731
Thrombocytopenia 16.38 9.64 2698 761840 346187 109478574
Rales 16.32 9.64 251 764287 24488 109800273
Torus fracture 16.28 9.64 11 764527 135 109824626
Dysuria 16.25 9.64 538 764000 59693 109765068
Acute graft versus host disease 16.25 9.64 41 764497 12840 109811921
Lipase increased 16.22 9.64 199 764339 18473 109806288
Achlorhydria 16.20 9.64 6 764532 16 109824745
Cerebral haemorrhage 16.20 9.64 575 763963 64393 109760368
Intestinal ulcer 16.17 9.64 45 764493 2382 109822379
Acute graft versus host disease in skin 16.17 9.64 31 764507 10709 109814052
Injection site haemorrhage 16.17 9.64 148 764390 32880 109791881
Cutaneous lupus erythematosus 16.15 9.64 57 764481 3431 109821330
Air embolism 16.13 9.64 21 764517 619 109824142
Ventricular flutter 16.12 9.64 10 764528 105 109824656
Respiratory tract malformation 16.12 9.64 10 764528 105 109824656
Fear of eating 15.99 9.64 19 764519 509 109824252
Compartment syndrome 15.98 9.64 82 764456 5828 109818933
Respiratory rate increased 15.98 9.64 253 764285 24830 109799931
Postictal state 15.96 9.64 45 764493 2401 109822360
Eyelid retraction 15.95 9.64 9 764529 78 109824683
Amino acid level increased 15.95 9.64 24 764514 812 109823949
Genital pain 15.95 9.64 32 764506 1368 109823393
Infusion site swelling 15.95 9.64 120 764418 9757 109815004
Gastrointestinal sounds abnormal 15.93 9.64 83 764455 5935 109818826
Peritonitis bacterial 15.91 9.64 126 764412 10407 109814354
Ventricular hyperkinesia 15.88 9.64 15 764523 306 109824455
Extensor plantar response 15.85 9.64 39 764499 1916 109822845
Venoocclusive liver disease 15.83 9.64 53 764485 15154 109809607
Hepatic cyst 15.79 9.64 100 764438 7683 109817078
Radiation inflammation 15.76 9.64 27 764511 1021 109823740
Blood lactic acid increased 15.70 9.64 173 764365 15648 109809113
Mental disorder 15.70 9.64 365 764173 38426 109786335
Drug reaction with eosinophilia and systemic symptoms 15.67 9.64 706 763832 81389 109743372
Acne 15.64 9.64 152 764386 33368 109791393
Blood uric acid increased 15.60 9.64 222 764316 21307 109803454
Thermohypoaesthesia 15.57 9.64 10 764528 112 109824649
Fibrin D dimer increased 15.55 9.64 119 764419 9726 109815035
Pruritus 15.53 9.64 4378 760160 577182 109247579
Stoma site haemorrhage 15.53 9.64 44 764494 2354 109822407
Disease progression 15.48 9.64 1464 763074 242570 109582191
Gastrointestinal stoma complication 15.45 9.64 54 764484 3235 109821526
Colitis ischaemic 15.35 9.64 189 764349 17561 109807200
Facial paralysis 15.34 9.64 244 764294 23970 109800791
Product administration error 15.31 9.64 351 764187 36866 109787895
Epstein-Barr virus associated lymphoproliferative disorder 15.30 9.64 7 764531 4795 109819966
Ischaemic cerebral infarction 15.28 9.64 50 764488 2895 109821866
Memory impairment 15.26 9.64 1163 763375 195781 109628980
Acute myocardial infarction 15.25 9.64 717 763821 83060 109741701
Urinary incontinence 15.24 9.64 442 764096 48145 109776616
Oedema mouth 15.23 9.64 52 764486 3078 109821683
COVID-19 pneumonia 15.19 9.64 350 764188 36793 109787968
Product contamination 15.10 9.64 38 764500 1893 109822868
Mean cell volume increased 15.06 9.64 104 764434 8226 109816535
Tongue blistering 15.03 9.64 38 764500 1899 109822862
Crystal nephropathy 15.02 9.64 37 764501 1819 109822942
Gallbladder adenocarcinoma 14.92 9.64 10 764528 121 109824640
Blood cholesterol decreased 14.90 9.64 47 764491 2669 109822092
Colorectal cancer 14.90 9.64 25 764513 9089 109815672
Graft versus host disease 14.88 9.64 73 764465 18733 109806028
Dactylitis 14.86 9.64 5 764533 4128 109820633
Tachyarrhythmia 14.86 9.64 103 764435 8158 109816603
Epigastric discomfort 14.82 9.64 110 764428 8905 109815856
Menstrual disorder 14.82 9.64 69 764469 4715 109820046
Myocardial ischaemia 14.75 9.64 263 764275 26421 109798340
Extrapyramidal disorder 14.72 9.64 128 764410 28739 109796022
Vena cava injury 14.71 9.64 15 764523 337 109824424
Hepatic haematoma 14.70 9.64 25 764513 940 109823821
Metastases to liver 14.66 9.64 165 764373 35221 109789540
Pancreatitis necrotising 14.65 9.64 76 764462 5425 109819336
Dermatitis exfoliative 14.62 9.64 131 764407 11216 109813545
Erythema 14.61 9.64 2262 762276 289185 109535576
Lymphangitis 14.52 9.64 33 764505 1539 109823222
Gene mutation 14.51 9.64 3 764535 3426 109821335
Herpes zoster 14.47 9.64 607 763931 107772 109716989
Pancytopenia 14.41 9.64 1658 762880 207955 109616806
Hypocalcaemic seizure 14.39 9.64 10 764528 129 109824632
SARS-CoV-2 antibody test positive 14.37 9.64 16 764522 399 109824362
Vascular anastomotic haemorrhage 14.30 9.64 14 764524 299 109824462
Sinus tachycardia 14.30 9.64 406 764132 44087 109780674
Magnesium deficiency 14.22 9.64 22 764516 763 109823998
Peritonitis 14.19 9.64 310 764228 32297 109792464
Red blood cell count decreased 14.17 9.64 574 763964 65349 109759412
Drug dose titration not performed 14.17 9.64 26 764512 1039 109823722
Atrioventricular block second degree 14.13 9.64 101 764437 8080 109816681
Papule 14.11 9.64 119 764419 10014 109814747
Yellow skin 14.08 9.64 61 764477 4041 109820720
Vaginal flatulence 14.05 9.64 137 764401 12007 109812754
Endocrine ophthalmopathy 14.02 9.64 30 764508 1343 109823418
Myocardial reperfusion injury 14.00 9.64 10 764528 135 109824626
Gastrointestinal erosion 14.00 9.64 27 764511 1121 109823640
Varicella zoster virus infection 13.99 9.64 14 764524 6354 109818407
Pneumothorax 13.97 9.64 331 764207 34954 109789807
Lower gastrointestinal haemorrhage 13.95 9.64 192 764346 18294 109806467
Small intestinal obstruction 13.94 9.64 306 764232 31907 109792854
Idiopathic pulmonary fibrosis 13.93 9.64 70 764468 4934 109819827
Decreased appetite 13.90 9.64 3596 760942 472250 109352511
Neurological symptom 13.90 9.64 58 764480 15550 109809211
Aminoaciduria 13.89 9.64 15 764523 361 109824400
Pulseless electrical activity 13.88 9.64 177 764361 16580 109808181
Arteriosclerotic gangrene 13.83 9.64 8 764530 73 109824688
Alkalosis 13.78 9.64 22 764516 784 109823977
Herpes simplex 13.78 9.64 59 764479 15705 109809056
Petechiae 13.67 9.64 232 764306 23085 109801676
Hyperaemia 13.64 9.64 57 764481 3716 109821045
Chronic graft versus host disease 13.64 9.64 28 764510 9429 109815332
Gastric xanthoma 13.59 9.64 5 764533 13 109824748
Splenic calcification 13.59 9.64 5 764533 13 109824748
Pregnancy with contraceptive device 13.58 9.64 5 764533 3902 109820859
Cardiac failure 13.57 9.64 1489 763049 186137 109638624
Derailment 13.56 9.64 8 764530 76 109824685
Hand-eye coordination impaired 13.53 9.64 7 764531 50 109824711
Haemophagocytic lymphohistiocytosis 13.53 9.64 146 764392 31413 109793348
Pseudomembranous colitis 13.52 9.64 83 764455 6308 109818453
Hypertonia 13.50 9.64 102 764436 8304 109816457
Appendicitis 13.49 9.64 274 764264 28190 109796571
Antibiotic level above therapeutic 13.47 9.64 25 764513 1008 109823753
Psychiatric decompensation 13.45 9.64 12 764526 5753 109819008
Device infusion issue 13.45 9.64 49 764489 2996 109821765
Vascular encephalopathy 13.42 9.64 22 764516 802 109823959
Primary hypoparathyroidism 13.42 9.64 7 764531 51 109824710
Peripheral circulatory failure 13.40 9.64 35 764503 1784 109822977
Polymyositis 13.39 9.64 56 764482 3652 109821109
Limb injury 13.39 9.64 348 764190 37288 109787473
Joint effusion 13.37 9.64 87 764451 20818 109803943
Ischaemic contracture of the left ventricle 13.35 9.64 10 764528 146 109824615
Large intestine infection 13.34 9.64 64 764474 4428 109820333
Bromhidrosis 13.33 9.64 5 764533 14 109824747
Neoplasm recurrence 13.31 9.64 10 764528 5222 109819539
Infectious crystalline keratopathy 13.30 9.64 8 764530 79 109824682
Glaucoma 13.27 9.64 96 764442 22421 109802340
Pancreatic enzyme abnormality 13.24 9.64 11 764527 188 109824573
Acute generalised exanthematous pustulosis 13.24 9.64 217 764321 21447 109803314
Avian influenza 13.22 9.64 9 764529 112 109824649
Blood chloride decreased 13.20 9.64 108 764430 9007 109815754
Incoherent 13.19 9.64 101 764437 8257 109816504
Latent tetany 13.18 9.64 4 764534 4 109824757
Multiple endocrine neoplasia Type 1 13.18 9.64 4 764534 4 109824757
Intraductal papillary breast neoplasm 13.18 9.64 4 764534 4 109824757
Oesophageal mucosa erythema 13.18 9.64 4 764534 4 109824757
Listless 13.17 9.64 64 764474 4451 109820310
Graft versus host disease in skin 13.16 9.64 23 764515 8231 109816530
Protein total decreased 13.16 9.64 124 764414 10766 109813995
Mouth haemorrhage 13.16 9.64 147 764391 13341 109811420
Hyperosmolar state 13.15 9.64 21 764517 749 109824012
Right atrial enlargement 13.11 9.64 17 764521 499 109824262
Product deposit 13.11 9.64 20 764518 685 109824076
Carbon dioxide decreased 13.09 9.64 66 764472 4658 109820103
Truncus coeliacus thrombosis 13.08 9.64 5 764533 15 109824746
Uveitis 13.06 9.64 92 764446 21618 109803143
Intracranial haemangioma 13.03 9.64 6 764532 32 109824729
Renal pain 12.99 9.64 114 764424 9703 109815058
Steatorrhoea 12.99 9.64 25 764513 1036 109823725
Nephrectomy 12.97 9.64 44 764494 2596 109822165
Hiccups 12.90 9.64 141 764397 12728 109812033
Blood electrolytes decreased 12.87 9.64 34 764504 1745 109823016
Miosis 12.82 9.64 94 764444 21889 109802872
Neoplasm progression 12.81 9.64 344 764194 64251 109760510
Pneumococcal sepsis 12.81 9.64 39 764499 2173 109822588
Electrocardiogram abnormal 12.80 9.64 191 764347 18518 109806243
Intraductal papillary mucinous neoplasm 12.75 9.64 22 764516 837 109823924
Nocardiosis 12.74 9.64 20 764518 7466 109817295
Toxic anterior segment syndrome 12.73 9.64 4 764534 3450 109821311
Hepatitis B reactivation 12.73 9.64 20 764518 7464 109817297
Metastases to bone 12.72 9.64 147 764391 31225 109793536
Mental status changes 12.70 9.64 646 763892 75476 109749285
Procedural pain 12.70 9.64 329 764209 35236 109789525
Acute psychosis 12.67 9.64 68 764470 4919 109819842
Fatigue 12.64 9.64 7952 756586 1208006 108616755
Premature delivery 12.62 9.64 143 764395 30489 109794272
Red blood cell analysis abnormal 12.62 9.64 5 764533 17 109824744
Vitamin A increased 12.62 9.64 5 764533 17 109824744
Acute pulmonary oedema 12.62 9.64 176 764362 16820 109807941
Hepatitis B 12.59 9.64 30 764508 9582 109815179
Suspected product quality issue 12.59 9.64 18 764520 581 109824180
Hyperparathyroidism 12.58 9.64 56 764482 3754 109821007
Reaction to excipient 12.58 9.64 37 764501 2022 109822739
Acute phase reaction 12.52 9.64 16 764522 463 109824298
Stoma closure 12.51 9.64 15 764523 406 109824355
Hyperlactacidaemia 12.45 9.64 99 764439 8187 109816574
Therapeutic product ineffective 12.44 9.64 43 764495 2561 109822200
Hypoproteinaemia 12.44 9.64 77 764461 5868 109818893
Food aversion 12.35 9.64 32 764506 1623 109823138
DNA antibody 12.33 9.64 6 764532 37 109824724
Rash rubelliform 12.30 9.64 4 764534 6 109824755
Conjunctivitis allergic 12.29 9.64 18 764520 6913 109817848
Intestinal obstruction 12.27 9.64 467 764071 52760 109772001
Extravasation 12.26 9.64 66 764472 4779 109819982
Product distribution issue 12.24 9.64 61 764477 4285 109820476
Respiratory distress 12.22 9.64 588 763950 68286 109756475
Drug dispensed to wrong patient 12.20 9.64 20 764518 729 109824032
Blood copper increased 12.20 9.64 6 764532 38 109824723
Erythrodermic psoriasis 12.17 9.64 36 764502 1974 109822787
Oesophageal stenosis 12.16 9.64 69 764469 5096 109819665
Hypertensive nephropathy 12.15 9.64 24 764514 1014 109823747
Abdominal wall haemorrhage 12.13 9.64 20 764518 733 109824028
Hypogammaglobulinaemia 12.12 9.64 85 764453 19991 109804770
Malnutrition 12.08 9.64 260 764278 27019 109797742
Nephroangiosclerosis 12.06 9.64 15 764523 422 109824339
Product dispensing error 12.03 9.64 169 764369 16176 109808585
Fibrinolysis 12.00 9.64 7 764531 65 109824696
Groin pain 11.96 9.64 161 764377 15267 109809494
Neuroglycopenia 11.95 9.64 25 764513 1101 109823660
Breast cancer female 11.95 9.64 45 764493 12423 109812338
Trapeziectomy 11.94 9.64 3 764535 0 109824761
Tracheal aspiration procedure 11.94 9.64 3 764535 0 109824761
Incorrect drug administration rate 11.94 9.64 72 764466 5436 109819325
Platelet distribution width abnormal 11.94 9.64 3 764535 0 109824761
Rib excision 11.94 9.64 3 764535 0 109824761
Wrong technique in product usage process 11.91 9.64 488 764050 86860 109737901
Renal cell carcinoma 11.88 9.64 91 764447 7439 109817322
Gout 11.84 9.64 334 764204 36232 109788529
Visceral pain 11.81 9.64 9 764529 135 109824626
Delusional disorder, persecutory type 11.81 9.64 18 764520 616 109824145
Lung adenocarcinoma stage IV 11.77 9.64 17 764521 554 109824207
Arterial haemorrhage 11.77 9.64 55 764483 3764 109820997
Duodenal perforation 11.75 9.64 44 764494 2726 109822035
Spondylolysis 11.74 9.64 11 764527 222 109824539
Hernial eventration 11.74 9.64 7 764531 68 109824693
Acute graft versus host disease in intestine 11.71 9.64 13 764525 5626 109819135
Nodule 11.68 9.64 157 764381 32474 109792287
Enterocolitis infectious 11.66 9.64 51 764487 3393 109821368
Proctitis 11.66 9.64 173 764365 16754 109808007
Urine chloride decreased 11.65 9.64 8 764530 101 109824660
Tracheo-oesophageal fistula 11.65 9.64 19 764519 690 109824071
Myoglobin blood increased 11.64 9.64 59 764479 4173 109820588
Hypovolaemic shock 11.64 9.64 153 764385 14430 109810331
Vulvovaginal ulceration 11.63 9.64 5 764533 22 109824739
Mood swings 11.62 9.64 222 764316 22590 109802171
Poor quality product administered 11.60 9.64 63 764475 4578 109820183
Base excess increased 11.59 9.64 9 764529 139 109824622
Catheter site haemorrhage 11.59 9.64 75 764463 5805 109818956
Electrocardiogram T wave inversion 11.53 9.64 73 764465 5607 109819154
Prothrombin level decreased 11.52 9.64 33 764505 1777 109822984
Deafness permanent 11.48 9.64 22 764516 909 109823852
Product monitoring error 11.47 9.64 103 764435 8824 109815937
Macular degeneration 11.45 9.64 212 764326 21447 109803314
Adenocarcinoma gastric 11.43 9.64 36 764502 2043 109822718
Product selection error 11.42 9.64 15 764523 446 109824315
Hyperchlorhydria 11.41 9.64 37 764501 2132 109822629
Albuminuria 11.39 9.64 23 764515 988 109823773
Hyperventilation 11.38 9.64 103 764435 8844 109815917
Lichen nitidus 11.38 9.64 9 764529 143 109824618
Acinetobacter test positive 11.37 9.64 12 764526 281 109824480
Ventricular enlargement 11.35 9.64 19 764519 705 109824056
Product complaint 11.32 9.64 147 764391 13825 109810936
Perineal cyst 11.31 9.64 11 764527 233 109824528
Non-cardiac chest pain 11.29 9.64 114 764424 10084 109814677
Neutrophil percentage decreased 11.28 9.64 22 764516 921 109823840
Antipsychotic drug level decreased 11.27 9.64 28 764510 1384 109823377
Rheumatoid lung 11.25 9.64 8 764530 4296 109820465
Pustular psoriasis 11.24 9.64 52 764486 13553 109811208
Oxygen saturation decreased 11.23 9.64 1245 763293 155737 109669024
Injection site erythema 11.23 9.64 534 764004 93642 109731119
Genital rash 11.21 9.64 27 764511 1308 109823453
Activated partial thromboplastin time prolonged 11.16 9.64 217 764321 22151 109802610
Lipidosis 11.14 9.64 6 764532 47 109824714
Formication 11.11 9.64 72 764466 5576 109819185
White blood cell count increased 11.10 9.64 795 763743 96047 109728714
Cold sweat 11.09 9.64 214 764324 21817 109802944
Cardiac flutter 11.08 9.64 73 764465 5684 109819077
Infusion site erythema 11.07 9.64 129 764409 11830 109812931
Cleft palate 11.03 9.64 14 764524 402 109824359
Skin exfoliation 11.00 9.64 725 763813 86926 109737835
Helicobacter test positive 10.98 9.64 27 764511 1326 109823435
Haematoma 10.97 9.64 502 764036 57974 109766787
Potentiating drug interaction 10.96 9.64 126 764412 11517 109813244
Hypoosmolar state 10.95 9.64 14 764524 405 109824356
Polymenorrhagia 10.93 9.64 6 764532 49 109824712
Injection site pain 10.91 9.64 1070 763468 176852 109647909
Spinal fusion surgery 10.90 9.64 30 764508 9126 109815635
Pulmonary alveolar haemorrhage 10.89 9.64 88 764450 20062 109804699
Gadolinium deposition disease 10.88 9.64 9 764529 153 109824608
Arteriovenous fistula operation 10.86 9.64 13 764525 351 109824410
Rebound effect 10.85 9.64 59 764479 14747 109810014
Coronary arterial stent insertion 10.85 9.64 15 764523 5900 109818861
Blood calcitonin increased 10.83 9.64 6 764532 50 109824711
Blood sodium abnormal 10.76 9.64 27 764511 1343 109823418
Cardiovascular disorder 10.76 9.64 219 764319 22541 109802220
Plicated tongue 10.73 9.64 9 764529 156 109824605
Central nervous system injury 10.73 9.64 9 764529 156 109824605
Tumour lysis syndrome 10.73 9.64 284 764254 30517 109794244
Lymphoproliferative disorder 10.73 9.64 21 764517 7197 109817564
Gastrointestinal polyp 10.71 9.64 10 764528 201 109824560
Stridor 10.70 9.64 83 764455 6812 109817949
Deafness bilateral 10.69 9.64 42 764496 2662 109822099
Infusion site thrombosis 10.69 9.64 12 764526 302 109824459
Respiratory alkalosis 10.69 9.64 72 764466 5649 109819112
Enzyme induction 10.67 9.64 8 764530 117 109824644
Neuralgia 10.63 9.64 423 764115 48055 109776706
Somatosensory evoked potentials abnormal 10.63 9.64 10 764528 203 109824558
Blood chloride increased 10.62 9.64 78 764460 6294 109818467
Cholecystitis 10.62 9.64 244 764294 25638 109799123
Herbal interaction 10.59 9.64 17 764521 609 109824152
Pneumonia streptococcal 10.57 9.64 50 764488 3439 109821322
Vitamin D decreased 10.53 9.64 130 764408 12085 109812676
Blood albumin abnormal 10.52 9.64 20 764518 821 109823940
Adrenal calcification 10.52 9.64 5 764533 29 109824732
Incorrect route of product administration 10.51 9.64 350 764188 63711 109761050
Acquired gene mutation 10.50 9.64 3 764535 2751 109822010
Serotonin syndrome 10.50 9.64 505 764033 58648 109766113
Pulmonary vascular disorder 10.47 9.64 23 764515 1048 109823713
Dermatomyositis 10.47 9.64 59 764479 4347 109820414
Urticaria vesiculosa 10.46 9.64 4 764534 12 109824749
Loss of employment 10.46 9.64 5 764533 3339 109821422
Blood 1,25-dihydroxycholecalciferol decreased 10.45 9.64 6 764532 54 109824707
Carotid artery thrombosis 10.44 9.64 33 764505 9605 109815156
Penile oedema 10.44 9.64 12 764526 310 109824451
Oral mucosal blistering 10.43 9.64 92 764446 7842 109816919
Androgenetic alopecia 10.41 9.64 11 764527 258 109824503
Occupational exposure to air contaminants 10.41 9.64 9 764529 163 109824598
Vulvar basal cell carcinoma 10.38 9.64 5 764533 30 109824731
Multiple sclerosis relapse 10.37 9.64 266 764272 49974 109774787
Nephritis allergic 10.36 9.64 23 764515 1056 109823705
Perineal cellulitis 10.35 9.64 6 764532 55 109824706
Incorrect dosage administered 10.34 9.64 54 764484 3864 109820897
Gastrointestinal stoma output increased 10.32 9.64 22 764516 982 109823779
Catheter site extravasation 10.32 9.64 16 764522 556 109824205
Bone pain 10.31 9.64 550 763988 64583 109760178
Nail bed bleeding 10.27 9.64 20 764518 836 109823925
Hepatitis 10.27 9.64 513 764025 89541 109735220
Oedema genital 10.27 9.64 17 764521 625 109824136
Product label on wrong product 10.26 9.64 6 764532 56 109824705
Poliomyelitis 10.26 9.64 6 764532 56 109824705
Body height decreased 10.25 9.64 115 764423 10448 109814313
Parotid gland haemorrhage 10.25 9.64 5 764533 31 109824730
Ischaemic hepatitis 10.23 9.64 61 764477 4587 109820174
Cataract 10.22 9.64 447 764091 79038 109745723
Paraneoplastic rash 10.22 9.64 7 764531 88 109824673
Sight disability 10.20 9.64 10 764528 214 109824547
Respirovirus test positive 10.17 9.64 8 764530 126 109824635
Sinonasal obstruction 10.17 9.64 13 764525 376 109824385
Acquired cystic kidney disease 10.17 9.64 6 764532 57 109824704
Epstein-Barr virus infection reactivation 10.15 9.64 8 764530 4076 109820685
Splenic injury 10.15 9.64 11 764527 266 109824495
Feeling drunk 10.14 9.64 69 764469 5431 109819330
Interstitial lung disease 10.14 9.64 827 763711 138507 109686254
Depressed mood 10.14 9.64 516 764022 60293 109764468
JC virus infection 10.13 9.64 13 764525 5277 109819484
Generalised oedema 10.09 9.64 281 764257 30423 109794338
Paternal exposure during pregnancy 10.09 9.64 10 764528 217 109824544
Mucosal dryness 10.07 9.64 57 764481 4206 109820555
Lip ulceration 10.07 9.64 42 764496 2736 109822025
pH body fluid abnormal 10.07 9.64 8 764530 128 109824633
Sepsis syndrome 10.06 9.64 29 764509 1567 109823194
Essential tremor 10.05 9.64 32 764506 1826 109822935
Genital haemorrhage 10.02 9.64 22 764516 7230 109817531
Gastric ischaemia 10.00 9.64 6 764532 59 109824702
Allergic reaction to excipient 10.00 9.64 19 764519 780 109823981
Intra-abdominal haematoma 9.97 9.64 49 764489 3423 109821338
Mean platelet volume increased 9.97 9.64 29 764509 1575 109823186
Neurologic neglect syndrome 9.96 9.64 32 764506 9266 109815495
Panic reaction 9.95 9.64 67 764471 5255 109819506
Fear 9.94 9.64 220 764318 22973 109801788
Mesenteric artery thrombosis 9.93 9.64 21 764517 932 109823829
Breast inflammation 9.92 9.64 9 764529 174 109824587
Alcohol use disorder 9.92 9.64 6 764532 60 109824701
Human anaplasmosis 9.90 9.64 7 764531 93 109824668
Biliary dyskinesia 9.90 9.64 38 764500 2383 109822378
Urine output 9.89 9.64 3 764535 3 109824758
Mean platelet volume abnormal 9.89 9.64 3 764535 3 109824758
Multiple epiphyseal dysplasia 9.89 9.64 3 764535 3 109824758
Stertor 9.89 9.64 3 764535 3 109824758
Gastric lavage abnormal 9.89 9.64 3 764535 3 109824758
Plethoric face 9.87 9.64 5 764533 34 109824727
Hepatobiliary infection 9.87 9.64 5 764533 34 109824727
Viral diarrhoea 9.87 9.64 16 764522 578 109824183
Prothrombin time prolonged 9.85 9.64 171 764367 17090 109807671
Pharyngeal oedema 9.83 9.64 164 764374 16264 109808497
Gastric antral vascular ectasia 9.83 9.64 24 764514 1173 109823588
Acute interstitial pneumonitis 9.82 9.64 27 764511 1419 109823342
SARS-CoV-2 test negative 9.81 9.64 35 764503 2118 109822643
Haematocrit 9.80 9.64 4 764534 15 109824746
Skin test positive 9.79 9.64 27 764511 1422 109823339
Pulmonary nocardiosis 9.77 9.64 3 764535 2626 109822135
Electrocardiogram ST segment depression 9.77 9.64 68 764470 5393 109819368
Blood creatinine abnormal 9.75 9.64 72 764466 5820 109818941
Eosinophil count increased 9.75 9.64 202 764336 20856 109803905
Generalised tonic-clonic seizure 9.74 9.64 467 764071 54213 109770548
Hypotonia 9.73 9.64 158 764380 15587 109809174
Subileus 9.72 9.64 77 764461 6360 109818401
Restlessness 9.71 9.64 479 764059 55780 109768981
Food intolerance 9.71 9.64 59 764479 4468 109820293
Systemic infection 9.70 9.64 35 764503 9784 109814977
Gastrointestinal mucosal necrosis 9.69 9.64 10 764528 228 109824533
Spontaneous haemorrhage 9.69 9.64 24 764514 1184 109823577
N-terminal prohormone brain natriuretic peptide 9.67 9.64 6 764532 63 109824698

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neurotoxicity 24.06 22.82 8 699 16 113230
Bone marrow failure 24.06 22.82 8 699 16 113230
Gasping syndrome 24.06 22.82 8 699 16 113230

Pharmacologic Action:

SourceCodeDescription
ATC B05CB04 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Salt solutions
ATC B05XA02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50503 laxative
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65265 antacid
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:77965 food anticaking agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

B05CB Salt solutions 3 drugs
magnesium citratesodium chloridesodium citrate
B05XA Electrolyte solutions 18 drugs
ammonium chloridecalcium chloridecalcium gluconatehydrochloric acidmagnesium chloridemagnesium phosphatemagnesium sulfatepotassium acetatepotassium chloridepotassium lactatepotassium phosphatesodium acetate show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Reduction of risk of upper gastrointestinal bleeding indication 37372002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
2MG/ML;84MG/ML KONVOMEP AZURITY N213593 Aug. 30, 2022 RX FOR SUSPENSION ORAL 11911473 July 16, 2039 REDUCTION OF RISK OF UPPER GASTROINTESTINAL BLEEDING IN CRITICALLY ILL PATIENTS
2MG/ML;84MG/ML KONVOMEP AZURITY N213593 Aug. 30, 2022 RX FOR SUSPENSION ORAL 11911473 July 16, 2039 SHORT TERM TREATMENT OF ACTIVE BENIGN GASTRIC ULCER
2MG/ML;84MG/ML KONVOMEP AZURITY N213593 Aug. 30, 2022 RX FOR SUSPENSION ORAL 11771686 March 1, 2040 SHORT TERM TREATMENT OF ACTIVE BENIGN GASTRIC ULCER

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018192 VUID
N0000146526 NUI
D01203 KEGG_DRUG
4018192 VANDF
C0074722 UMLSCUI
CHEBI:32139 CHEBI
CHEMBL1353 ChEMBL_ID
D017693 MESH_DESCRIPTOR_UI
DB01390 DRUGBANK_ID
8MDF5V39QO UNII
516892 PUBCHEM_CID
36676 RXNORM
1720 MMSL
5473 MMSL
d00440 MMSL
000743 NDDF
001116 NDDF
011039 NDDF
387319002 SNOMEDCT_US
57376006 SNOMEDCT_US
8MDF5V39QO INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Good Sense Omeprazole and Sodium Bicarbonate HUMAN OTC DRUG LABEL 2 0113-0058 CAPSULE, GELATIN COATED 1100 mg ORAL ANDA 15 sections
Good Sense Omeprazole and Sodium Bicarbonate HUMAN OTC DRUG LABEL 2 0113-0058 CAPSULE, GELATIN COATED 1100 mg ORAL ANDA 15 sections
Alka-Seltzer Heartburn HUMAN OTC DRUG LABEL 2 0280-0047 TABLET, EFFERVESCENT 1940 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Heartburn Relief Extra Strength HUMAN OTC DRUG LABEL 2 0280-0079 TABLET, EFFERVESCENT 1976 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Heartburn Relief Lemon Lime HUMAN OTC DRUG LABEL 2 0280-0083 TABLET, EFFERVESCENT 1650 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Heartburn and Pain HUMAN OTC DRUG LABEL 3 0280-0160 TABLET, EFFERVESCENT 1916 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Extra Strength HUMAN OTC DRUG LABEL 3 0280-0211 GRANULE, EFFERVESCENT 1985 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Original HUMAN OTC DRUG LABEL 3 0280-4000 TABLET, EFFERVESCENT 1916 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Gold HUMAN OTC DRUG LABEL 3 0280-4100 TABLET, EFFERVESCENT 1050 mg ORAL OTC Monograph Drug 16 sections
CEO-TWO HUMAN OTC DRUG LABEL 2 0283-1023 SUPPOSITORY 0.60 g RECTAL OTC Monograph Drug 15 sections
CEO-TWO HUMAN OTC DRUG LABEL 2 0283-1023 SUPPOSITORY 0.60 g RECTAL OTC Monograph Drug 15 sections
Walgreens Effervescent Pain Relief HUMAN OTC DRUG LABEL 3 0363-0421 TABLET, EFFERVESCENT 1916 mg ORAL OTC Monograph Drug 17 sections
Walgreens Antacid Pain Relief Extra Strength HUMAN OTC DRUG LABEL 3 0363-0541 TABLET, EFFERVESCENT 1985 mg ORAL OTC Monograph Drug 17 sections
Walgreens Antacid Pain Relief Extra Strength HUMAN OTC DRUG LABEL 3 0363-0541 TABLET, EFFERVESCENT 1985 mg ORAL OTC Monograph Drug 17 sections
Omeprazole and sodium bicarbonate HUMAN OTC DRUG LABEL 2 0363-0732 CAPSULE, GELATIN COATED 1100 mg ORAL ANDA 15 sections
Omeprazole and sodium bicarbonate HUMAN OTC DRUG LABEL 2 0363-0732 CAPSULE, GELATIN COATED 1100 mg ORAL ANDA 15 sections
Omeprazole and sodium bicarbonate HUMAN OTC DRUG LABEL 2 0363-0732 CAPSULE, GELATIN COATED 1100 mg ORAL ANDA 15 sections
Omeprazole and sodium bicarbonate HUMAN OTC DRUG LABEL 2 0363-0732 CAPSULE, GELATIN COATED 1100 mg ORAL ANDA 15 sections
Well at Walgreens HUMAN OTC DRUG LABEL 2 0363-0801 POWDER, FOR SOLUTION 700 mg NASAL unapproved drug other 11 sections
Well at Walgreens HUMAN OTC DRUG LABEL 2 0363-0801 POWDER, FOR SOLUTION 700 mg NASAL unapproved drug other 11 sections
Well at Walgreens HUMAN OTC DRUG LABEL 2 0363-0802 POWDER, FOR SOLUTION 700 mg NASAL unapproved drug other 11 sections
Well at Walgreens HUMAN OTC DRUG LABEL 2 0363-0802 POWDER, FOR SOLUTION 700 mg NASAL unapproved drug other 11 sections
Humco Sodium Bicarbonate HUMAN OTC DRUG LABEL 1 0395-2685 POWDER 1000 mg ORAL OTC Monograph Drug 11 sections
Sodium Bicarbonate HUMAN OTC DRUG LABEL 1 0395-9124 POWDER 1000 mg ORAL OTC monograph final 10 sections
SODIUM BICARBONATE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9951 INJECTION, SOLUTION 42 mg INTRAVENOUS ANDA 11 sections
SODIUM BICARBONATE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9951 INJECTION, SOLUTION 42 mg INTRAVENOUS ANDA 11 sections
SODIUM BICARBONATE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9951 INJECTION, SOLUTION 42 mg INTRAVENOUS ANDA 11 sections
SODIUM BICARBONATE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9951 INJECTION, SOLUTION 42 mg INTRAVENOUS ANDA 11 sections
Sodium Bicarbonate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9980 INJECTION, SOLUTION 84 mg INTRAVENOUS unapproved drug other 12 sections
Sodium Bicarbonate HUMAN PRESCRIPTION DRUG LABEL 1 0409-4900 INJECTION, SOLUTION 84 mg INTRAVENOUS ANDA 12 sections