hydroquinone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3282 123-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 1,4-Benzenediol
  • hydroquinone
  • benzene-1,4-diol
  • idrochinone
skin depigmentation agent
  • Molecular weight: 110.11
  • Formula: C6H6O2
  • CLOGP: 0.81
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -0.06
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 18, 2002 FDA GALDERMA LABS LP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Squamous cell carcinoma of skin 280.10 154.73 34 57 737 2357257
Skin atrophy 164.74 154.73 21 70 624 2357370

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC D11AX11 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
CHEBI has role CHEBI:85046 skin lightening agent
MeSH PA D000975 Antioxidants
MeSH PA D009153 Mutagens
MeSH PA D009676 Noxae
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
FDA PE N0000175851 Depigmenting Activity
FDA EPC N0000175854 Melanin Synthesis Inhibitor
FDA MoA N0000175850 Melanin Synthesis Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Discoloration of skin indication 3253007
Chloasma indication 36209000
Facial Hyperpigmentation indication
Sunburn contraindication 23346002
Eczema contraindication 43116000
Telangiectasia disorder contraindication 247479008
Pregnancy, function contraindication 289908002
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.26 acidic
pKa2 11.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 3 Enzyme Ki 5.09 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 4.38 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 4.97 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 4.97 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 4.85 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.49 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.11 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 4.90 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 7.05 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 4.13 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 4.97 CHEMBL
Carbonic anhydrase Unclassified Ki 5.23 CHEMBL
Polyphenol oxidase 2 Enzyme IC50 5.01 CHEMBL

External reference:

IDSource
4018886 VUID
N0000147180 NUI
C0020306 UMLSCUI
D00073 KEGG_DRUG
74583006 SNOMEDCT_US
387422001 SNOMEDCT_US
4849 MMSL
5509 RXNORM
1507 MMSL
4018886 VANDF
002019 NDDF
785 PUBCHEM_CID
CHEBI:17594 CHEBI
CHEMBL537 ChEMBL_ID
HQE PDB_CHEM_ID
DB09526 DRUGBANK_ID
XV74C1N1AE UNII
C031927 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
AMBI Fade HUMAN OTC DRUG LABEL 2 0187-5479 CREAM 20 mg TOPICAL OTC monograph not final 9 sections
AMBI Fade HUMAN OTC DRUG LABEL 2 0187-5480 CREAM 20 mg TOPICAL OTC monograph not final 9 sections
Differin Dark Spot Correcting Serum HUMAN OTC DRUG LABEL 1 0299-4608 SOLUTION 2 g TOPICAL OTC monograph not final 9 sections
TRI-LUMA HUMAN PRESCRIPTION DRUG LABEL 3 0299-5950 CREAM 40 mg TOPICAL NDA 15 sections
Proactiv Advanced Dark Spot Correcting Serum HUMAN OTC DRUG LABEL 1 11410-045 LIQUID 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 9 sections
Artra Skin Tone for Oily Skin HUMAN OTC DRUG LABEL 3 12022-000 CREAM 75 mg TOPICAL OTC monograph not final 6 sections
Artra Skin Tone for Normal Skin HUMAN OTC DRUG LABEL 3 12022-001 CREAM 20 mg TOPICAL OTC monograph not final 6 sections
Artra Skin Tone for Dry Skin HUMAN OTC DRUG LABEL 3 12022-002 CREAM 20 mg TOPICAL OTC monograph not final 6 sections
Black and White Skin Bleach HUMAN OTC DRUG LABEL 1 12022-003 CREAM 20 mg TOPICAL OTC monograph not final 6 sections
Nadinola Skin Fade for Dry Skin HUMAN OTC DRUG LABEL 2 12022-012 CREAM 20 mg TOPICAL OTC monograph not final 6 sections
Nadinola Skin Fade for Oily Skin HUMAN OTC DRUG LABEL 2 12022-013 CREAM 20 mg TOPICAL OTC monograph not final 6 sections
Nadinola Skin FadeExtra HUMAN OTC DRUG LABEL 2 12022-014 CREAM 30 mg TOPICAL OTC monograph not final 6 sections
Nadinola Skin Fade for Normal Skin HUMAN OTC DRUG LABEL 2 12022-015 CREAM 30 mg TOPICAL OTC monograph not final 6 sections
Othine Skin Bleach HUMAN OTC DRUG LABEL 2 12022-016 CREAM 30 mg TOPICAL OTC monograph not final 6 sections
Skin Lightening HUMAN OTC DRUG LABEL 1 14222-1615 LIQUID 2 mL TOPICAL OTC monograph not final 2 sections
Skin Lightening Accelerator Pack HUMAN OTC DRUG LABEL 2 14222-5000 KIT 2 g None OTC monograph not final 8 sections
Skin Lightening Accelerator Pack HUMAN OTC DRUG LABEL 2 14222-5000 KIT 2 g None OTC monograph not final 8 sections
REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots HUMAN OTC DRUG LABEL 6 14222-5030 KIT 2 g TOPICAL unapproved drug other 9 sections
REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots HUMAN OTC DRUG LABEL 6 14222-5030 KIT 2 g TOPICAL unapproved drug other 9 sections
REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel Size HUMAN OTC DRUG LABEL 6 14222-5035 KIT 2 g TOPICAL unapproved drug other 10 sections
REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel Size HUMAN OTC DRUG LABEL 6 14222-5035 KIT 2 g TOPICAL unapproved drug other 10 sections
Skin Beautifying Milk HUMAN OTC DRUG LABEL 1 16708-001 CREAM 0.02 g TOPICAL OTC monograph not final 11 sections
Medicated Fade Creme with Sunscreen HUMAN OTC DRUG LABEL 2 16708-002 CREAM 0.02 g TOPICAL OTC monograph not final 10 sections
Advanced Lightning HUMAN OTC DRUG LABEL 2 24623-042 CREAM 0.02 g TOPICAL OTC MONOGRAPH NOT FINAL 8 sections
Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 24979-141 CREAM 40 mg TOPICAL Unapproved drug other 13 sections
hydroquinone time release HUMAN PRESCRIPTION DRUG LABEL 1 24979-144 CREAM 40 mg TOPICAL Unapproved drug other 13 sections
Hydro-Q HUMAN PRESCRIPTION DRUG LABEL 1 30815-0040 GEL 40 mg TOPICAL UNAPPROVED DRUG OTHER 13 sections
HYDROQUINONE 4% HUMAN PRESCRIPTION DRUG LABEL 1 42192-151 CREAM 40 mg TOPICAL unapproved drug other 19 sections
Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 42582-700 CREAM 40 mg TOPICAL UNAPPROVED DRUG OTHER 13 sections
MELAMIN Skin Bleaching and Correcting HUMAN PRESCRIPTION DRUG LABEL 1 42851-030 CREAM 0.04 g TOPICAL UNAPPROVED DRUG OTHER 9 sections