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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
rolitetracycline ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antibiotics, protein-synthesis inhibitors, tetracycline derivatives
2399
751-97-3
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
synterin
rolitetracycline
A pyrrolidinylmethyl TETRACYCLINE.
Molecular weight: 527.57
Formula: C27H33N3O8
CLOGP: 0.05
LIPINSKI: 3
HAC: 11
HDO: 6
TPSA: 170.87
ALOGS: -2.47
ROTB: 4
Drug dosage:
Dose
Unit
Route
0.35
g
P
ADMET properties:
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Property
Value
Reference
t_half (Half-life)
8.80 hours
Lombardo F, Berellini G, Obach RS
EoM (Fraction excreted unchanged in urine)
55 %
Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)
1250 mg/mL
Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)
11.05 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
CL (Clearance)
0.97 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.54 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.50 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 8 of 8 entries
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01AA09
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
TETRACYCLINES
Tetracyclines
CHEBI has role
CHEBI:35820
antiprotozoal drugs
CHEBI has role
CHEBI:36047
antibacterial drugs
CHEBI has role
CHEBI:48001
protein synthesis inhibitors
CHEBI has role
CHEBI:50266
Prodrugs
MeSH PA
D000900
Anti-Bacterial Agents
MeSH PA
D000890
Anti-Infective Agents
Showing 1 to 7 of 7 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
3.72
acidic
pKa2
7.59
acidic
pKa3
9.76
acidic
pKa4
11.9
acidic
pKa5
13.05
acidic
pKa6
13.72
acidic
pKa7
9.07
Basic
pKa8
8.21
Basic
Showing 1 to 8 of 8 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Insulin-degrading enzyme
Enzyme
P14735
IDE_HUMAN
IC50
4
CHEMBL
DNA repair protein RAD52 homolog
Nuclear other
P43351
RAD52_HUMAN
IC50
4.54
CHEMBL
Integrase
Enzyme
Q7ZJM1_9HIV1
IC50
4.55
CHEMBL
Integrase
Enzyme
Q76353_9HIV1
IC50
4.55
CHEMBL
Showing 1 to 4 of 4 entries
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External reference:
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entries
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ID
Source
002746
NDDF
1041
INN_ID
12760
IUPHAR_LIGAND_ID
54682938
PUBCHEM_CID
9462
RXNORM
96076003
SNOMEDCT_US
C0035823
UMLSCUI
CHEBI:63334
CHEBI
CHEMBL1237046
ChEMBL_ID
D012382
MESH_DESCRIPTOR_UI
Showing 1 to 10 of 14 entries
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Pharmaceutical products:
None
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rolitetracycline