clomocycline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, protein-synthesis inhibitors, tetracycline derivatives 702 1181-54-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clomocycline
  • chlormethylenecycline
  • Molecular weight: 508.91
  • Formula: C23H25ClN2O9
  • CLOGP: -0.49
  • LIPINSKI: 3
  • HAC: 11
  • HDO: 7
  • TPSA: 187.86
  • ALOGS: -2.46
  • ROTB: 3

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CG,PIM1,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 69
kinase-selectivity-class AXL,BRAF,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,JAK2,MAP2K6,MAP3K14,MAPK7,STK33,SYK,TEK,TGFBR1 15
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01AA11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
TETRACYCLINES
Tetracyclines
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35820 antiprotozoal drug
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:48001 protein synthesis inhibitor

Related Drugs by ATC class:

J01AA Tetracyclines 13 drugs
chlortetracyclinedemeclocyclinedoxycyclinelymecyclinemetacyclineminocyclineomadacyclineoxytetracyclinepenimepicyclinerolitetracyclinesarecyclinetetracycline show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.19 acidic
pKa2 6.82 acidic
pKa3 7.49 acidic
pKa4 11.9 acidic
pKa5 12.54 acidic
pKa6 13.14 acidic
pKa7 9.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06885 KEGG_DRUG
21272 RXNORM
C0055923 UMLSCUI
CHEBI:59589 CHEBI
CHEMBL2106071 ChEMBL_ID
DB00453 DRUGBANK_ID
C007090 MESH_SUPPLEMENTAL_RECORD_UI
13541 IUPHAR_LIGAND_ID
2151 INN_ID
YP0241BU76 UNII
54680675 PUBCHEM_CID
005557 NDDF
419950007 SNOMEDCT_US
768907002 SNOMEDCT_US

Pharmaceutical products:

None