ritodrine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetics 2390 26652-09-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • DU21220
  • yutopar
  • ritodrine
  • lavopa
  • ritodrine hydrochloride
  • ritodrine HCl
An adrenergic beta-2 agonist used to control PREMATURE LABOR.
  • Molecular weight: 287.36
  • Formula: C17H21NO3
  • CLOGP: 1.65
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -3.21
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.97 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 30 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 31 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.64 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 22, 1991 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure during pregnancy 229.67 129.82 75 529 108137 46577321
Maternal exposure during pregnancy 200.82 129.82 67 537 102482 46582976
Premature delivery 134.61 129.82 35 569 22034 46663424

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC G02CA01 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
OTHER GYNECOLOGICALS
Sympathomimetics, labour repressants
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D015149 Tocolytic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Premature labor indication 6383007
Chorioamnionitis contraindication 11612004
Gestational diabetes mellitus contraindication 11687002 DOID:11714
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Antepartum hemorrhage contraindication 34842007
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Mild pre-eclampsia contraindication 41114007
Conduction disorder of the heart contraindication 44808001
Severe pre-eclampsia contraindication 46764007
Pulmonary hypertension contraindication 70995007 DOID:6432
Eclampsia in pregnancy contraindication 198992004
Fetal death contraindication 276507005
Hypertensive urgency contraindication 443482000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.35 acidic
pKa2 11.01 acidic
pKa3 8.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST EC50 7.62 WOMBAT-PK CHEMBL
Beta-3 adrenergic receptor GPCR EC50 6.72 WOMBAT-PK

External reference:

IDSource
4019928 VUID
N0000148013 NUI
D01263 KEGG_DRUG
23239-51-2 SECONDARY_CAS_RN
4018621 VANDF
4019928 VANDF
C0013256 UMLSCUI
CHEBI:8872 CHEBI
CHEMBL785 ChEMBL_ID
CHEMBL83063 ChEMBL_ID
CHEMBL1201160 ChEMBL_ID
CHEMBL1367605 ChEMBL_ID
D012312 MESH_DESCRIPTOR_UI
31729 PUBCHEM_CID
7294 IUPHAR_LIGAND_ID
2608 INN_ID
DB00867 DRUGBANK_ID
I0Q6O6740J UNII
105470 RXNORM
1276 MMSL
1407 MMSL
5430 MMSL
d00603 MMSL
001813 NDDF
004732 NDDF
372893009 SNOMEDCT_US
86257005 SNOMEDCT_US
89785009 SNOMEDCT_US

Pharmaceutical products:

None