buphenine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
analgesics, glafenine derivatives (subgroup of fenamic acid group) 1976 447-41-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nylidrin hydrochloride
  • nylidrin
  • buphenin
  • buphenine
  • nilidrine
  • nylidrin HCl
A beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.
  • Molecular weight: 299.41
  • Formula: C19H25NO2
  • CLOGP: 3.01
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 52.49
  • ALOGS: -4.17
  • ROTB: 7

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 22
kinase-selectivity-class AXL,CDK4,EIF2AK3,EPHB4,GRK2,MAP2K6 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AA02 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
2-amino-1-phenylethanol derivatives
ATC G02CA02 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
OTHER GYNECOLOGICALS
Sympathomimetics, labour repressants
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014665 Vasodilator Agents
MeSH PA D015149 Tocolytic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
CHEBI has role CHEBI:35554 cardiovascular drug

Related Drugs by ATC class:

C04AA 2-amino-1-phenylethanol derivatives 2 drugs
bamethanisoxsuprine
G02CA Sympathomimetics, labour repressants 2 drugs
fenoterolritodrine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of blood vessel indication 27550009 DOID:178
Inner Ear Disturbance indication
Tachyarrhythmia contraindication 6285003
Paroxysmal tachycardia contraindication 12026006
Myocardial infarction contraindication 22298006 DOID:5844
Heart disease contraindication 56265001 DOID:114
Thyrotoxicosis contraindication 90739004 DOID:7997
Decompensated cardiac failure contraindication 195111005
Myocardial infarction in recovery phase contraindication 418044006
Progressive Angina Pectoris contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.52 acidic
pKa2 9.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Adrenergic receptor alpha-1 GPCR Kd 6.21 CHEMBL

External reference:

IDSource
4017871 VUID
N0000179434 NUI
D01543 KEGG_DRUG
849-55-8 SECONDARY_CAS_RN
4017871 VANDF
4019862 VANDF
C0028735 UMLSCUI
CHEBI:748467 CHEBI
CHEMBL114655 ChEMBL_ID
CHEMBL1204337 ChEMBL_ID
DB06152 DRUGBANK_ID
4567 PUBCHEM_CID
7595 RXNORM
000699 NDDF
004516 NDDF
111140007 SNOMEDCT_US
44520000 SNOMEDCT_US
D009756 MESH_DESCRIPTOR_UI
461 INN_ID
EC69E3PW7E UNII
EC69E3PW7E INXIGHT DRUGS

Pharmaceutical products:

None