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framycetin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1896 | 119-04-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 50 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 40 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 140.85 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK4,CDK5,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK1,NTRK2,PDK2,PRKDC,TEK,TGFBR1,ZAP70 | 22 | |||
| kinase-selectivity-class | CHUK,MAP2K6,PDK1 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D09AA01 | DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives |
| ATC | R01AX08 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations |
| ATC | S01AA07 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:50904 | allergen |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
| CHEBI has role | CHEBI:77715 | nasal decongestant |
Related Drugs by ATC class:
D09AA Medicated dressings with antiinfectives 11 drugs
R01AX Other nasal preparations 6 drugs
S01AA Antibiotics 27 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.52 | acidic |
| pKa2 | 13.26 | acidic |
| pKa3 | 13.86 | acidic |
| pKa4 | 8.21 | Basic |
| pKa5 | 7.99 | Basic |
| pKa6 | 7.39 | Basic |
| pKa7 | 6.59 | Basic |
| pKa8 | 6.31 | Basic |
| pKa9 | 5.7 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | Ion channel | IC50 | 6.40 | CHEMBL | |||||
| Lecithin retinol acyltransferase | Enzyme | IC50 | 4.83 | CHEMBL | |||||
| Menin | Nuclear other | Kd | 4.81 | CHEMBL | |||||
| Phenylalanine--tRNA ligase beta subunit | Enzyme | WOMBAT-PK | |||||||
| 30S ribosomal protein S12 | Cytosolic other | WOMBAT-PK | |||||||
| Phenylalanine--tRNA ligase alpha subunit | Enzyme | WOMBAT-PK | |||||||
| Lethal factor | Enzyme | Ki | 6.30 | CHEMBL | |||||
| Extracellular calcium-sensing receptor | GPCR | AGONIST | Kd | 4 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D05140 | KEGG_DRUG |
| CHEBI:7508 | CHEBI |
| CHEMBL184618 | ChEMBL_ID |
| CHEMBL3989769 | ChEMBL_ID |
| 253 | INN_ID |
| DB00452 | DRUGBANK_ID |
| 4BOC774388 | UNII |
| 235749 | RXNORM |
| 003514 | NDDF |
| 003515 | NDDF |
| 373765007 | SNOMEDCT_US |
| 442008002 | SNOMEDCT_US |
| 50520001 | SNOMEDCT_US |
| C0016673 | UMLSCUI |
| D005601 | MESH_DESCRIPTOR_UI |
| NMY | PDB_CHEM_ID |
| 8378 | PUBCHEM_CID |
| 4BOC774388 | INXIGHT DRUGS |
Pharmaceutical products:
None