framycetin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1896 119-04-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Neomycin B sulfate
  • Neomycin B
  • framycetin
A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
  • Molecular weight: 614.65
  • Formula: C23H46N6O13
  • CLOGP: -6.47
  • LIPINSKI: 3
  • HAC: 19
  • HDO: 13
  • TPSA: 353.11
  • ALOGS: -0.98
  • ROTB: 9

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 6.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 40 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 140.85 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D09AA01 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R01AX08 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Other nasal preparations
ATC S01AA07 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drug

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.52 acidic
pKa2 13.26 acidic
pKa3 13.86 acidic
pKa4 8.21 Basic
pKa5 7.99 Basic
pKa6 7.39 Basic
pKa7 6.59 Basic
pKa8 6.31 Basic
pKa9 5.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Phenylalanine--tRNA ligase alpha subunit Enzyme WOMBAT-PK
Phenylalanine--tRNA ligase beta subunit Enzyme WOMBAT-PK
30S ribosomal protein S12 Cytosolic other WOMBAT-PK
Extracellular calcium-sensing receptor Unclassified AGONIST Kd 4 IUPHAR

External reference:

IDSource
D005601 MESH_DESCRIPTOR_UI
C0770899 UMLSCUI
D05140 KEGG_DRUG
4BOC774388 UNII
253 INN_ID
50520001 SNOMEDCT_US
4556 RXNORM
003514 NDDF
373765007 SNOMEDCT_US
CHEMBL184618 ChEMBL_ID
DB00452 DRUGBANK_ID
CHEBI:7508 CHEBI
CHEMBL3989769 ChEMBL_ID
8378 PUBCHEM_CID

Pharmaceutical products:

None