indapamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diuretics, sulfamoylbenzoic acid derivatives 1433 26807-65-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metindamide
  • indapamide hemihydrate
  • indapamide
  • flupamid
  • indaflex
  • indamide
  • indamol
  • veroxil
  • (+/-)-Indapamide
A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
  • Molecular weight: 365.83
  • Formula: C16H16ClN3O3S
  • CLOGP: 2.96
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 92.50
  • ALOGS: -4.03
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.59 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.20 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,CAMK2D,CDK5,CDK9,EGFR,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,MAPKAPK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TTK 19
kinase-selectivity-class AXL,BRAF,CDK9,DDR1,EIF2AK3,GRK2,MAP2K6,MAPKAPK3,PDK1,PDK4,PIK3CD,SIK2,SIK3,STK33,TEK 15
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 6, 1983 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1694.81 13.46 851 30128 132687 90464781
Hypokalaemia 651.76 13.46 457 30522 130659 90466809
Acute kidney injury 399.15 13.46 518 30461 319869 90277599
Inappropriate antidiuretic hormone secretion 269.02 13.46 132 30847 19373 90578095
Drug interaction 188.23 13.46 338 30641 276115 90321353
Hypomagnesaemia 140.14 13.46 108 30871 35480 90561988
Hypochloraemia 120.51 13.46 42 30937 2580 90594888
Conjoined twins 113.33 13.46 28 30951 502 90596966
Lactic acidosis 105.66 13.46 107 30872 50356 90547112
Maternal exposure during pregnancy 96.23 13.46 7 30972 360056 90237412
Confusional state 95.92 13.46 320 30659 385885 90211583
Blood pressure increased 94.09 13.46 208 30771 197009 90400459
Hyponatraemic seizure 89.48 13.46 23 30956 487 90596981
Burning mouth syndrome 85.66 13.46 23 30956 580 90596888
Torsade de pointes 84.83 13.46 57 30922 15125 90582343
Pemphigus 80.23 13.46 9 30970 326855 90270613
Pericarditis 79.19 13.46 3 30976 270148 90327320
Bradycardia 73.56 13.46 115 30864 83732 90513736
Glossodynia 71.56 13.46 12 30967 321767 90275701
Labile hypertension 70.13 13.46 19 30960 496 90596972
Rectal polyp 67.65 13.46 22 30957 1091 90596377
Central nervous system lupus 67.16 13.46 23 30956 1340 90596128
Hypoglycaemia 65.77 13.46 99 30880 69749 90527719
Infusion related reaction 64.39 13.46 31 30948 416749 90180719
Congenital bladder anomaly 63.66 13.46 15 30964 218 90597250
Intestinal malrotation 63.30 13.46 17 30962 429 90597039
Urachal abnormality 63.15 13.46 15 30964 226 90597242
Change of bowel habit 62.46 13.46 25 30954 2258 90595210
Persistent cloaca 62.37 13.46 15 30964 239 90597229
Infection 62.23 13.46 23 30956 362071 90235397
Dehydration 62.05 13.46 176 30803 194271 90403197
Electrocardiogram QT prolonged 61.65 13.46 98 30881 72358 90525110
Rhabdomyolysis 60.60 13.46 81 30898 51175 90546293
Renal artery stenosis 60.12 13.46 24 30955 2153 90595315
Euglycaemic diabetic ketoacidosis 59.73 13.46 33 30946 6168 90591300
Drug ineffective 59.46 13.46 258 30721 1384040 89213428
Alopecia 57.28 13.46 51 30928 495020 90102448
Arthropathy 56.93 13.46 27 30952 366215 90231253
Butterfly rash 56.58 13.46 23 30956 2162 90595306
Hypotension 55.30 13.46 239 30740 325158 90272310
Intestinal haemorrhage 55.11 13.46 28 30951 4419 90593049
Fall 53.03 13.46 313 30666 481497 90115971
Exposure during pregnancy 52.75 13.46 9 30970 238401 90359067
Treatment failure 52.73 13.46 19 30960 303909 90293559
Wound 52.46 13.46 19 30960 302961 90294507
Atrial fibrillation 51.77 13.46 130 30849 133481 90463987
Discomfort 51.38 13.46 15 30964 274320 90323148
Hepatic enzyme increased 51.05 13.46 30 30949 360706 90236762
Off label use 49.98 13.46 201 30778 1102051 89495417
Swelling 49.88 13.46 42 30937 419016 90178452
Urine odour abnormal 49.84 13.46 31 30948 7213 90590255
Impaired healing 49.33 13.46 10 30969 234189 90363279
Left ventricular hypertrophy 49.25 13.46 29 30950 6115 90591353
Osmotic demyelination syndrome 48.88 13.46 17 30962 1037 90596431
Proctalgia 48.75 13.46 32 30947 8166 90589302
Systemic lupus erythematosus 48.57 13.46 32 30947 361864 90235604
Metabolic acidosis 48.32 13.46 76 30903 55600 90541868
Sensitisation 48.02 13.46 25 30954 4150 90593318
Injection site discomfort 47.51 13.46 28 30951 5912 90591556
Blood sodium decreased 46.20 13.46 52 30927 27561 90569907
Dysuria 46.17 13.46 62 30917 39339 90558129
Vessel puncture site haemorrhage 44.44 13.46 10 30969 117 90597351
Furuncle 43.71 13.46 29 30950 7532 90589936
Scleroedema 43.47 13.46 10 30969 130 90597338
Renal impairment 43.41 13.46 105 30874 105316 90492152
Orthostatic hypotension 43.29 13.46 62 30917 41765 90555703
Product packaging confusion 43.29 13.46 11 30968 222 90597246
Blood urea increased 42.14 13.46 52 30927 30361 90567107
Lupus nephritis 41.89 13.46 24 30955 4808 90592660
Polyp 41.03 13.46 28 30951 7616 90589852
Jaundice 40.93 13.46 53 30926 32464 90565004
Protein urine present 40.89 13.46 27 30952 6957 90590511
Contraindicated product administered 40.71 13.46 30 30949 320109 90277359
Duodenal ulcer 39.81 13.46 30 30949 9522 90587946
Oliguria 39.12 13.46 31 30948 10593 90586875
Sprue-like enteropathy 38.98 13.46 14 30965 939 90596529
Spur cell anaemia 38.87 13.46 8 30971 59 90597409
Urine abnormality 38.38 13.46 27 30952 7710 90589758
Urinary incontinence 37.88 13.46 55 30924 37511 90559957
Diabetes mellitus 37.39 13.46 74 30905 64801 90532667
Stomatitis 37.24 13.46 24 30955 274674 90322794
Psoriatic arthropathy 36.76 13.46 16 30963 228319 90369149
Hypertensive angiopathy 36.52 13.46 8 30971 82 90597386
Migraine 36.40 13.46 10 30969 190382 90407086
Nephropathy 36.28 13.46 28 30951 9207 90588261
Failure to suspend medication 36.26 13.46 8 30971 85 90597383
Angioedema 36.19 13.46 73 30906 64803 90532665
Dyslipidaemia 36.16 13.46 29 30950 10078 90587390
Swelling face 35.62 13.46 83 30896 81269 90516199
Frustration tolerance decreased 35.60 13.46 26 30953 7870 90589598
Death 35.15 13.46 64 30915 456487 90140981
Renin increased 34.68 13.46 9 30970 198 90597270
Bladder disorder 34.54 13.46 29 30950 10743 90586725
Heart rate decreased 34.49 13.46 64 30915 53441 90544027
Mass 34.38 13.46 34 30945 15543 90581925
Sinusitis 34.35 13.46 40 30939 343048 90254420
Presyncope 34.18 13.46 48 30931 31757 90565711
Peripheral coldness 33.81 13.46 32 30947 13860 90583608
Needle issue 33.73 13.46 32 30947 13902 90583566
Blood creatinine increased 33.51 13.46 93 30886 101293 90496175
Abdominal discomfort 33.22 13.46 71 30908 477257 90120211
Myalgia 33.12 13.46 133 30846 174992 90422476
Type 2 diabetes mellitus 33.10 13.46 14 30965 203230 90394238
Postoperative wound infection 32.82 13.46 31 30948 13395 90584073
Hyperkalaemia 32.61 13.46 70 30909 64894 90532574
Product dose omission issue 32.57 13.46 31 30948 291656 90305812
Syncope 32.01 13.46 109 30870 132554 90464914
Glomerular filtration rate decreased 32.00 13.46 34 30945 16898 90580570
Circulatory collapse 31.98 13.46 41 30938 24863 90572605
Blood uric acid abnormal 31.84 13.46 8 30971 154 90597314
Hyperlactacidaemia 31.78 13.46 19 30960 4117 90593351
COVID-19 pneumonia 31.73 13.46 35 30944 18142 90579326
Croup infectious 31.55 13.46 11 30968 676 90596792
Injury 31.49 13.46 14 30965 197335 90400133
Disorientation 31.28 13.46 55 30924 44059 90553409
Eosinophilia 30.57 13.46 43 30936 28490 90568978
Electrolyte imbalance 30.35 13.46 39 30940 23706 90573762
Vascular access site haemorrhage 30.09 13.46 8 30971 194 90597274
Blood pressure systolic increased 29.44 13.46 63 30916 58282 90539186
Blood electrolytes abnormal 29.34 13.46 12 30967 1146 90596322
Gait inability 29.32 13.46 7 30972 146449 90451019
Somnolence 29.14 13.46 145 30834 208939 90388529
Thyroid disorder 28.91 13.46 33 30946 17752 90579716
Labelled drug-drug interaction medication error 28.84 13.46 30 30949 14552 90582916
Lower respiratory tract infection 28.73 13.46 26 30953 250633 90346835
Gravitational oedema 28.65 13.46 12 30967 1217 90596251
Therapeutic product effect decreased 28.16 13.46 32 30947 277539 90319929
Ill-defined disorder 28.14 13.46 14 30965 184877 90412591
Drug intolerance 27.60 13.46 71 30908 447520 90149948
Blood creatine phosphokinase increased 27.54 13.46 45 30934 33978 90563490
Retinal detachment 27.49 13.46 21 30958 6801 90590667
Blood pressure inadequately controlled 26.95 13.46 20 30959 6204 90591264
Haematoma 26.80 13.46 48 30931 39000 90558468
Poor dental condition 26.67 13.46 9 30970 501 90596967
Hypersensitivity 26.61 13.46 74 30905 454603 90142865
Diabetic metabolic decompensation 26.24 13.46 13 30966 1944 90595524
Ischaemic stroke 26.15 13.46 35 30944 22131 90575337
Drug hypersensitivity 26.00 13.46 77 30902 463532 90133936
Obesity 25.62 13.46 3 30976 105504 90491964
Vasculitis 25.51 13.46 35 30944 22658 90574810
Urine glucose/creatinine ratio increased 25.40 13.46 7 30972 195 90597273
Bursitis 25 13.46 7 30972 131647 90465821
Psychomotor retardation 24.43 13.46 17 30962 4772 90592696
Platelet dysfunction 24.37 13.46 6 30973 106 90597362
Drug level increased 24.22 13.46 38 30941 27724 90569744
Lethargy 23.99 13.46 61 30918 63078 90534390
Stevens-Johnson syndrome 23.97 13.46 39 30940 29337 90568131
Tubulointerstitial nephritis 23.96 13.46 36 30943 25307 90572161
Mucocutaneous haemorrhage 23.95 13.46 6 30973 114 90597354
Metabolic alkalosis 23.94 13.46 15 30964 3534 90593934
Glycosylated haemoglobin increased 23.83 13.46 28 30951 15534 90581934
Hypouricaemia 23.55 13.46 7 30972 257 90597211
Paramnesia 23.54 13.46 4 30975 8 90597460
Gastrointestinal disorder 23.52 13.46 32 30947 256655 90340813
Convulsive threshold lowered 23.49 13.46 8 30971 458 90597010
Sleep disorder 23.34 13.46 20 30959 198010 90399458
Musculoskeletal stiffness 23.31 13.46 41 30938 296491 90300977
Anuria 23.26 13.46 27 30952 14791 90582677
Depression 23.24 13.46 42 30937 300559 90296909
Blister 23.15 13.46 32 30947 254966 90342502
Transplant dysfunction 22.93 13.46 17 30962 5265 90592203
Therapy non-responder 22.93 13.46 9 30970 136695 90460773
Nail injury 22.74 13.46 9 30970 789 90596679
Glomerular filtration rate increased 22.73 13.46 12 30967 2048 90595420
Dizziness 22.72 13.46 304 30675 588980 90008488
Hypovolaemic shock 22.54 13.46 19 30960 7075 90590393
Sleep disorder due to general medical condition, insomnia type 22.38 13.46 8 30971 128686 90468782
Inflammation 22.35 13.46 17 30962 178575 90418893
Cardiovascular insufficiency 22.34 13.46 11 30968 1624 90595844
Cough 22.29 13.46 208 30771 368754 90228714
Urine albumin/creatinine ratio increased 22.08 13.46 8 30971 550 90596918
Vascular resistance systemic 21.70 13.46 4 30975 15 90597453
Blood urine present 21.49 13.46 28 30951 17250 90580218
Mouth ulceration 21.13 13.46 44 30935 39930 90557538
Blood cholesterol increased 21.07 13.46 24 30955 207988 90389480
Nasal mucosal disorder 21.01 13.46 11 30968 1846 90595622
Cardiac failure 20.56 13.46 83 30896 109413 90488055
Arrhythmia 20.54 13.46 45 30934 42287 90555181
Angina unstable 20.40 13.46 18 30961 7125 90590343
Liver injury 20.38 13.46 17 30962 170550 90426918
Blood pressure abnormal 20.15 13.46 29 30950 19616 90577852
Oedema peripheral 20.13 13.46 154 30825 257761 90339707
Sciatica 19.99 13.46 5 30974 101377 90496091
Gallbladder disorder 19.97 13.46 29 30950 19774 90577694
Hypotonia 19.94 13.46 22 30957 11404 90586064
Urine output decreased 19.84 13.46 23 30956 12580 90584888
Product use issue 19.81 13.46 53 30926 329866 90267602
Rheumatoid arthritis 19.77 13.46 61 30918 362553 90234915
Catheter site thrombosis 19.70 13.46 7 30972 455 90597013
Malaise 19.66 13.46 295 30684 585691 90011777
Lung neoplasm malignant 19.50 13.46 32 30947 24241 90573227
Product use in unapproved indication 19.46 13.46 55 30924 336181 90261287
Rash maculo-papular 19.28 13.46 43 30936 40890 90556578
Adverse event 19.25 13.46 8 30971 117410 90480058
Rash 19.14 13.46 177 30802 795923 89801545
Arteriosclerosis 19.12 13.46 21 30958 10832 90586636
Helicobacter infection 19.09 13.46 30 30949 226820 90370648
Renal failure 19.06 13.46 92 30887 130915 90466553
Impaired work ability 19.05 13.46 28 30951 19298 90578170
Blood glucose decreased 18.98 13.46 31 30948 23398 90574070
Weight increased 18.97 13.46 76 30903 417851 90179617
Peripheral venous disease 18.92 13.46 3 30976 83918 90513550
Prescribed overdose 18.89 13.46 5 30974 97620 90499848
Pharyngeal swelling 18.85 13.46 20 30959 9924 90587544
Food interaction 18.76 13.46 9 30970 1255 90596213
Musculoskeletal discomfort 18.69 13.46 29 30950 20962 90576506
Hypovolaemia 18.43 13.46 22 30957 12409 90585059
Pyelonephritis acute 18.20 13.46 15 30964 5417 90592051
Tinnitus 17.80 13.46 43 30936 43059 90554409
Night sweats 17.78 13.46 11 30968 128755 90468713
Hepatitis D 17.76 13.46 4 30975 47 90597421
Protrusion tongue 17.36 13.46 6 30973 359 90597109
Liver disorder 17.25 13.46 10 30969 121259 90476209
Spinal pain 17.24 13.46 24 30955 15743 90581725
Serratia infection 16.94 13.46 8 30971 1077 90596391
Vulvovaginal inflammation 16.85 13.46 8 30971 1090 90596378
Intracranial haematoma 16.83 13.46 6 30973 394 90597074
Leukocyturia 16.64 13.46 9 30970 1613 90595855
Myocardial ischaemia 16.58 13.46 22 30957 13792 90583676
Inclusion body myositis 16.55 13.46 3 30976 10 90597458
Hypertensive crisis 16.44 13.46 25 30954 17759 90579709
Fear of eating 16.38 13.46 6 30973 426 90597042
Hypocalciuria 16.33 13.46 3 30976 11 90597457
Electrocardiogram ST-T segment abnormal 16.26 13.46 6 30973 435 90597033
Blood glucose increased 16.16 13.46 70 30909 95176 90502292
Chronic gastritis 16.15 13.46 12 30967 3729 90593739
Interstitial lung disease 16.04 13.46 60 30919 76345 90521123
Iron deficiency 15.90 13.46 18 30961 9594 90587874
Iliac artery stenosis 15.87 13.46 4 30975 78 90597390
Injection site erythema 15.69 13.46 7 30972 98495 90498973
Injection site reaction 15.54 13.46 6 30973 92074 90505394
Hyperlipidaemia 15.51 13.46 28 30951 22888 90574580
Lipase increased 15.39 13.46 19 30960 11092 90586376
Pseudogynaecomastia 15.33 13.46 4 30975 90 90597378
Vasoconstriction 15.29 13.46 7 30972 878 90596590
Pain 15.03 13.46 245 30734 996096 89601372
Swollen tongue 15.03 13.46 42 30937 45914 90551554
Hospitalisation 15.02 13.46 13 30966 128087 90469381
Injection site mass 14.96 13.46 27 30952 22063 90575405
Drug reaction with eosinophilia and systemic symptoms 14.90 13.46 40 30939 42718 90554750
Extranodal marginal zone B-cell lymphoma (MALT type) 14.77 13.46 6 30973 563 90596905
Limb discomfort 14.69 13.46 37 30942 38023 90559445
Loss of consciousness 14.66 13.46 90 30889 140148 90457320
Asthenia 14.64 13.46 260 30719 533491 90063977
Hip arthroplasty 14.56 13.46 4 30975 76204 90521264
Angle closure glaucoma 14.50 13.46 10 30969 2765 90594703
Angular cheilitis 14.47 13.46 7 30972 994 90596474
Gastric ulcer haemorrhage 14.41 13.46 13 30966 5298 90592170
Retinopathy hypertensive 14.39 13.46 5 30974 304 90597164
Lip swelling 14.35 13.46 37 30942 38573 90558895
Febrile neutropenia 14.23 13.46 20 30959 158329 90439139
Fatigue 14.21 13.46 294 30685 1153729 89443739
Hypocalcaemia 14.13 13.46 39 30940 42329 90555139
Gingival hypertrophy 14.09 13.46 9 30970 2191 90595277
Neglect of personal appearance 14.08 13.46 4 30975 125 90597343
Nephritis allergic 14.07 13.46 5 30974 325 90597143
Postoperative hypertension 14.05 13.46 3 30976 27 90597441
Acetonaemia 14.04 13.46 5 30974 327 90597141
Proteinuria 13.94 13.46 27 30952 23264 90574204
Haemoglobin decreased 13.94 13.46 99 30880 161857 90435611
Colitis ischaemic 13.81 13.46 19 30960 12327 90585141
Electrocardiogram U-wave abnormality 13.76 13.46 3 30976 30 90597438
Drug ineffective for unapproved indication 13.71 13.46 3 30976 66641 90530827
Ear disorder 13.67 13.46 12 30967 4718 90592750
Intentional product use issue 13.66 13.46 34 30945 216858 90380610
Lymphocytic infiltration 13.63 13.46 7 30972 1129 90596339

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 318.80 13.65 316 20649 101146 42499224
Hypokalaemia 262.25 13.65 243 20722 71478 42528892
Acute kidney injury 164.93 13.65 473 20492 366864 42233506
Drug interaction 86.61 13.65 308 20657 266691 42333679
Death 82.27 13.65 67 20898 471118 42129252
Hypomagnesaemia 78.77 13.65 83 20882 28405 42571965
Bradycardia 57.84 13.65 129 20836 85355 42515015
Syncope 57.43 13.65 141 20824 99265 42501105
Drug ineffective 54.71 13.65 146 20819 630051 41970319
Hyperkalaemia 52.84 13.65 120 20845 80338 42520032
Off label use 52.35 13.65 152 20813 638183 41962187
Dizziness 49.69 13.65 248 20717 249006 42351364
Lactic acidosis 48.57 13.65 83 20882 45178 42555192
Tachyarrhythmia 46.13 13.65 27 20938 3905 42596465
Mucosal dryness 44.59 13.65 20 20945 1658 42598712
Atrial fibrillation 42.53 13.65 158 20807 139435 42460935
Postictal paralysis 42.44 13.65 13 20952 364 42600006
Left atrial dilatation 40.62 13.65 21 20944 2381 42597989
Hypoosmolar state 38.78 13.65 10 20955 146 42600224
Lipoprotein (a) increased 38.64 13.65 12 20953 352 42600018
Drug abuse 37.37 13.65 4 20961 104767 42495603
Angioedema 36.80 13.65 71 20894 42406 42557964
Haematocrit increased 36.52 13.65 20 20945 2547 42597823
Obesity 35.27 13.65 42 20923 16417 42583953
Inappropriate antidiuretic hormone secretion 33.47 13.65 41 20924 16500 42583870
Rhabdomyolysis 33.28 13.65 99 20866 77920 42522450
Hypotension 32.29 13.65 227 20738 257404 42342966
Myalgia 32.00 13.65 112 20853 95968 42504402
Arrhythmia 30.86 13.65 64 20901 40253 42560117
Spinal osteoarthritis 30.83 13.65 29 20936 8657 42591713
Drug dispensed to wrong patient 30.70 13.65 11 20954 506 42599864
Oedema peripheral 30.37 13.65 140 20825 135936 42464434
Presyncope 29.39 13.65 45 20920 22342 42578028
Febrile neutropenia 29.17 13.65 29 20936 185674 42414696
Herbal interaction 28.82 13.65 10 20955 418 42599952
Haemoglobin increased 27.89 13.65 22 20943 5184 42595186
Dyspnoea exertional 26.69 13.65 69 20896 50079 42550291
Lip swelling 26.00 13.65 39 20926 19014 42581356
Endoscopy upper gastrointestinal tract abnormal 25.82 13.65 6 20959 55 42600315
Type 2 diabetes mellitus 25.48 13.65 38 20927 18433 42581937
Carotid arteriosclerosis 24.71 13.65 15 20950 2317 42598053
Glycosylated haemoglobin decreased 24.63 13.65 9 20956 438 42599932
Varicose vein 24.54 13.65 13 20952 1549 42598821
Pancreatic neoplasm 23.95 13.65 11 20954 963 42599407
Consciousness fluctuating 23.70 13.65 12 20953 1303 42599067
Intention tremor 23.47 13.65 9 20956 501 42599869
Diabetic foot 23.27 13.65 16 20949 3057 42597313
Hypovolaemia 22.48 13.65 28 20937 11457 42588913
Tumour invasion 22.28 13.65 8 20957 370 42600000
Skin disorder 22.15 13.65 34 20931 16910 42583460
Electrolyte imbalance 21.92 13.65 34 20931 17067 42583303
Hypochloraemia 21.28 13.65 10 20955 923 42599447
Nail pitting 21.13 13.65 8 20957 430 42599940
Renal artery arteriosclerosis 21.12 13.65 5 20960 50 42600320
Renal artery restenosis 20.93 13.65 4 20961 12 42600358
Product use in unapproved indication 20.61 13.65 37 20928 184419 42415951
Pulse abnormal 20.41 13.65 11 20954 1357 42599013
Peripheral artery haematoma 19.93 13.65 5 20960 65 42600305
Postural tremor 19.91 13.65 8 20957 505 42599865
Onychophagia 19.86 13.65 5 20960 66 42600304
Gastrointestinal ischaemia 19.83 13.65 7 20958 308 42600062
Bundle branch block right 19.57 13.65 22 20943 8084 42592286
Pneumonia 19.37 13.65 125 20840 422024 42178346
Blood bilirubin abnormal 19.00 13.65 9 20956 845 42599525
Renal mass 18.99 13.65 12 20953 1990 42598380
Polyuria 18.95 13.65 24 20941 9987 42590383
Stenosis 18.46 13.65 12 20953 2089 42598281
Angular cheilitis 18.45 13.65 6 20959 205 42600165
Erectile dysfunction 18.42 13.65 39 20926 24874 42575496
Ventricular flutter 18.31 13.65 5 20960 92 42600278
Cholestasis 18.28 13.65 46 20919 32833 42567537
Resting tremor 17.65 13.65 9 20956 992 42599378
Electrocardiogram T wave abnormal 17.58 13.65 11 20954 1793 42598577
Diabetes mellitus inadequate control 17.53 13.65 29 20936 15361 42585009
Blood pressure inadequately controlled 17.29 13.65 13 20952 2855 42597515
Disorientation 17.27 13.65 48 20917 36341 42564029
Hepatic ischaemia 17.27 13.65 7 20958 452 42599918
Hypoparathyroidism 17.24 13.65 8 20957 717 42599653
Metastases to peritoneum 16.79 13.65 12 20953 2437 42597933
Renal pain 16.63 13.65 14 20951 3613 42596757
Apraxia 16.59 13.65 10 20955 1525 42598845
Potentiating drug interaction 16.38 13.65 18 20947 6450 42593920
Arterial stenosis 16.19 13.65 9 20956 1180 42599190
Confusional state 16.13 13.65 139 20826 167458 42432912
Oedema genital 16.11 13.65 7 20958 538 42599832
Respiratory failure 15.89 13.65 24 20941 128108 42472262
Renal failure 15.88 13.65 123 20842 143603 42456767
Wheezing 15.81 13.65 61 20904 54720 42545650
Gingival hypoplasia 15.70 13.65 3 20962 9 42600361
Toxicity to various agents 15.59 13.65 59 20906 229077 42371293
Peripheral arterial occlusive disease 15.56 13.65 18 20947 6820 42593550
Swollen tongue 15.42 13.65 33 20932 21198 42579172
Crepitations 15.33 13.65 13 20952 3388 42596982
External ear pain 15.03 13.65 3 20962 12 42600358
Silent myocardial infarction 14.85 13.65 6 20959 384 42599986
Urinary retention 14.72 13.65 50 20915 42164 42558206
Wrong dose 14.20 13.65 8 20957 1076 42599294
Product prescribing issue 14.04 13.65 17 20948 6756 42593614
Dyslipidaemia 13.89 13.65 20 20945 9398 42590972
Product dose omission issue 13.86 13.65 35 20930 154330 42446040
Ephelides 13.72 13.65 4 20961 94 42600276
Pancytopenia 13.71 13.65 23 20942 117720 42482650
Hyperthyroidism 13.69 13.65 25 20940 14316 42586054

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1719.13 12.05 1111 47524 216542 110324122
Hypokalaemia 840.04 12.05 672 47963 181776 110358888
Acute kidney injury 505.27 12.05 957 47678 634473 109906191
Drug interaction 250.38 12.05 626 48009 499557 110041107
Inappropriate antidiuretic hormone secretion 242.21 12.05 163 48472 33688 110506976
Hypomagnesaemia 212.72 12.05 191 48444 60179 110480485
Lactic acidosis 137.13 12.05 186 48449 92625 110448039
Bradycardia 123.74 12.05 235 48400 155282 110385382
Hypochloraemia 117.14 12.05 48 48587 3570 110537094
Atrial fibrillation 114.10 12.05 287 48348 229355 110311309
Confusional state 104.19 12.05 445 48190 468235 110072429
Off label use 101.57 12.05 331 48304 1499854 109040810
Maternal exposure during pregnancy 94.88 12.05 4 48631 254879 110285785
Completed suicide 89.57 12.05 4 48631 242377 110298287
Blood pressure increased 85.53 12.05 279 48356 258094 110282570
Drug ineffective 85.52 12.05 362 48273 1520178 109020486
Syncope 84.23 12.05 237 48398 202299 110338365
Death 83.70 12.05 111 48524 698758 109841906
Rhabdomyolysis 81.39 12.05 170 48465 120231 110420433
Pericarditis 79.72 12.05 4 48631 219110 110321554
Hyponatraemic seizure 79.58 12.05 24 48611 715 110539949
Hyperkalaemia 77.36 12.05 179 48456 135617 110405047
Burning mouth syndrome 77.15 12.05 23 48612 658 110540006
Hypotension 76.84 12.05 442 48193 523407 110017257
Treatment failure 71.54 12.05 17 48618 277217 110263447
Torsade de pointes 70.82 12.05 67 48568 22533 110518131
Infusion related reaction 69.06 12.05 41 48594 381121 110159543
Dizziness 64.15 12.05 525 48110 697668 109842996
Presyncope 63.30 12.05 92 48543 48795 110491869
Labile hypertension 62.56 12.05 19 48616 580 110540084
Myalgia 62.11 12.05 227 48408 222154 110318510
Pemphigus 61.99 12.05 10 48625 214560 110326104
Angioedema 61.86 12.05 135 48500 98365 110442299
Central nervous system lupus 61.66 12.05 23 48612 1330 110539334
Hypoglycaemia 58.54 12.05 146 48489 115958 110424706
Folliculitis 58.12 12.05 4 48631 167649 110373015
Duodenal ulcer perforation 56.80 12.05 6 48629 177694 110362970
Swelling 56.55 12.05 43 48592 350998 110189666
Electrocardiogram QT prolonged 55.97 12.05 138 48497 108822 110431842
Osmotic demyelination syndrome 55.52 12.05 24 48611 2039 110538625
Rectal polyp 55.26 12.05 22 48613 1518 110539146
Change of bowel habit 53.93 12.05 26 48609 2843 110537821
Blood sodium decreased 53.86 12.05 75 48560 38244 110502420
Infection 53.84 12.05 48 48587 362152 110178512
Exposure during pregnancy 52.63 12.05 6 48629 167418 110373246
Stomatitis 51.92 12.05 27 48608 270215 110270449
Drug abuse 51.85 12.05 8 48627 177403 110363261
Butterfly rash 51.55 12.05 23 48612 2108 110538556
Glossodynia 50.98 12.05 17 48618 221987 110318677
Impaired healing 50.87 12.05 12 48623 196705 110343959
Renal artery stenosis 50.30 12.05 27 48608 3699 110536965
Fall 50.21 12.05 444 48191 603038 109937626
Wound 48.76 12.05 21 48614 234416 110306248
Dehydration 48.45 12.05 247 48388 279264 110261400
Arrhythmia 47.89 12.05 99 48536 69476 110471188
Electrolyte imbalance 46.94 12.05 69 48566 36959 110503705
Disorientation 46.83 12.05 99 48536 70572 110470092
Alopecia 46.65 12.05 55 48580 364698 110175966
Arthropathy 46.58 12.05 35 48600 287487 110253177
Orthostatic hypotension 46.46 12.05 95 48540 66154 110474510
Rheumatoid factor positive 46.04 12.05 3 48632 131637 110409027
Febrile neutropenia 45.86 12.05 43 48592 316724 110223940
Psoriatic arthropathy 45.30 12.05 15 48620 196746 110343918
Discomfort 45.02 12.05 19 48616 214688 110325976
Metabolic acidosis 44.69 12.05 120 48515 99624 110441040
Sinusitis 44.47 12.05 39 48596 296649 110244015
Muscle injury 44.38 12.05 5 48630 140802 110399862
Hypovolaemia 44.09 12.05 51 48584 21623 110519041
Oedema peripheral 43.42 12.05 270 48365 328390 110212274
Sensitisation 42.26 12.05 25 48610 4126 110536538
Dyslipidaemia 41.96 12.05 43 48592 15922 110524742
Joint range of motion decreased 41.96 12.05 3 48632 121829 110418835
Left ventricular hypertrophy 40.99 12.05 39 48596 13205 110527459
Product use in unapproved indication 40.54 12.05 85 48550 447292 110093372
Migraine 39.66 12.05 13 48622 171639 110369025
Scleroedema 39.21 12.05 10 48625 157 110540507
Blood pressure inadequately controlled 39.07 12.05 30 48605 7603 110533061
Systemic lupus erythematosus 38.64 12.05 33 48602 254305 110286359
Jaundice 38.11 12.05 82 48553 59154 110481510
Intestinal haemorrhage 37.90 12.05 29 48606 7312 110533352
Urine odour abnormal 37.64 12.05 29 48606 7386 110533278
Postictal paralysis 37.49 12.05 13 48622 608 110540056
Injection site discomfort 37.24 12.05 28 48607 6879 110533785
Lupus nephritis 37.18 12.05 24 48611 4621 110536043
Lip swelling 37.13 12.05 74 48561 50593 110490071
Vessel puncture site haemorrhage 36.99 12.05 10 48625 199 110540465
Contraindicated product administered 36.76 12.05 33 48602 248234 110292430
Needle issue 36.32 12.05 42 48593 17798 110522866
Ill-defined disorder 36.03 12.05 12 48623 156841 110383823
Drug hypersensitivity 35.75 12.05 93 48542 453997 110086667
Renin increased 35.63 12.05 11 48624 355 110540309
Blood creatinine increased 35.52 12.05 167 48468 182722 110357942
Hepatic enzyme increased 35.33 12.05 54 48581 320838 110219826
Injury 35.11 12.05 17 48618 177248 110363416
Left atrial dilatation 35.09 12.05 21 48614 3539 110537125
Product packaging confusion 34.97 12.05 11 48624 378 110540286
Therapeutic product effect decreased 34.38 12.05 34 48601 244282 110296382
Hypoosmolar state 34.17 12.05 11 48624 408 110540256
Mucosal dryness 34.06 12.05 22 48613 4241 110536423
Glomerular filtration rate decreased 33.91 12.05 52 48583 28904 110511760
Furuncle 33.66 12.05 29 48606 8639 110532025
Renal failure 33.66 12.05 192 48443 226382 110314282
Hypertensive angiopathy 33.36 12.05 8 48627 96 110540568
C-reactive protein abnormal 33.35 12.05 8 48627 129687 110410977
Renal impairment 32.96 12.05 167 48468 188278 110352386
Tachyarrhythmia 32.82 12.05 28 48607 8233 110532431
Product dose omission issue 32.75 12.05 57 48578 321725 110218939
Proctalgia 31.87 12.05 34 48601 13188 110527476
Euglycaemic diabetic ketoacidosis 31.81 12.05 32 48603 11591 110529073
Glycosylated haemoglobin increased 31.37 12.05 45 48590 23574 110517090
Spur cell anaemia 31.35 12.05 8 48627 126 110540538
Swelling face 30.78 12.05 100 48535 92221 110448443
Myelosuppression 30.62 12.05 3 48632 94337 110446327
Dysuria 30.62 12.05 76 48559 60155 110480509
Urine abnormality 30.49 12.05 28 48607 9068 110531596
Hypersensitivity 30.09 12.05 85 48550 403913 110136751
Therapy non-responder 29.78 12.05 16 48619 157291 110383373
Lower respiratory tract infection 29.65 12.05 38 48597 243068 110297596
Nephropathy 29.62 12.05 33 48602 13434 110527230
Angular cheilitis 29.60 12.05 13 48622 1148 110539516
Frustration tolerance decreased 29.51 12.05 27 48608 8704 110531960
Lethargy 29.09 12.05 99 48536 93477 110447187
Pain 28.75 12.05 275 48360 954680 109585984
Ischaemic stroke 28.73 12.05 59 48576 41204 110499460
Metabolic alkalosis 28.66 12.05 22 48613 5573 110535091
Injection site reaction 28.48 12.05 3 48632 89067 110451597
Polyp 28.28 12.05 28 48607 9952 110530712
Diabetes mellitus 28.19 12.05 102 48533 99279 110441385
Bursitis 28.03 12.05 11 48624 129907 110410757
Drug dispensed to wrong patient 27.92 12.05 11 48624 738 110539926
Sprue-like enteropathy 27.80 12.05 14 48621 1682 110538982
Blood urea increased 27.57 12.05 69 48566 54888 110485776
Tubulointerstitial nephritis 27.07 12.05 68 48567 54216 110486448
Haematocrit increased 26.50 12.05 20 48615 4939 110535725
Herbal interaction 26.20 12.05 10 48625 616 110540048
Vascular access site haemorrhage 26.07 12.05 8 48627 253 110540411
Product use issue 25.94 12.05 62 48573 311633 110229031
Circulatory collapse 25.94 12.05 58 48577 42935 110497729
Blood pressure abnormal 25.88 12.05 40 48595 22384 110518280
Endoscopy upper gastrointestinal tract abnormal 25.84 12.05 6 48629 62 110540602
Bladder disorder 25.72 12.05 28 48607 11109 110529555
Mass 25.49 12.05 37 48598 19593 110521071
Musculoskeletal stiffness 25.47 12.05 53 48582 279769 110260895
Swollen tongue 25.42 12.05 71 48564 60291 110480373
Cholestasis 25.33 12.05 74 48561 64444 110476220
Diabetic foot 25.24 12.05 18 48617 4077 110536587
Thyroid disorder 25.03 12.05 34 48601 16935 110523729
Protein urine present 25.01 12.05 28 48607 11456 110529208
Dyspnoea exertional 24.75 12.05 101 48534 103959 110436705
Helicobacter test positive 24.65 12.05 12 48623 1341 110539323
Blood cholesterol increased 24.54 12.05 27 48608 184758 110355906
Sleep disorder due to general medical condition, insomnia type 24.40 12.05 8 48627 105635 110435029
Croup infectious 24.34 12.05 11 48624 1039 110539625
Oliguria 23.98 12.05 35 48600 18622 110522042
Blood glucose decreased 23.97 12.05 45 48590 29443 110511221
Hypotonia 23.91 12.05 32 48603 15713 110524951
Cardiovascular insufficiency 23.91 12.05 16 48619 3272 110537392
Adverse event 23.83 12.05 9 48626 108800 110431864
Hypocalcaemia 23.80 12.05 73 48562 65293 110475371
Diabetic metabolic decompensation 23.75 12.05 17 48618 3872 110536792
Pneumonia 23.68 12.05 259 48376 876455 109664209
Nocturia 23.50 12.05 33 48602 16957 110523707
Malaise 23.35 12.05 420 48215 671399 109869265
Road traffic accident 23.33 12.05 9 48626 107389 110433275
Glomerular filtration rate increased 23.23 12.05 13 48622 1932 110538732
Retinopathy hypertensive 23.21 12.05 9 48626 579 110540085
Drug intolerance 23.16 12.05 96 48539 406416 110134248
Potentiating drug interaction 23.02 12.05 27 48608 11616 110529048
Lower limb fracture 22.94 12.05 3 48632 75345 110465319
Postoperative wound infection 22.39 12.05 31 48604 15722 110524942
Rheumatoid arthritis 22.33 12.05 63 48572 299550 110241114
Eosinophilia 22.32 12.05 66 48569 57870 110482794
Pharyngeal swelling 22.30 12.05 27 48608 12005 110528659
Peripheral venous disease 22.00 12.05 5 48630 84112 110456552
Blood uric acid abnormal 21.86 12.05 8 48627 438 110540226
Poor dental condition 21.85 12.05 9 48626 678 110539986
Abdominal discomfort 21.82 12.05 94 48541 393764 110146900
Inflammation 21.76 12.05 32 48603 193206 110347458
Gait inability 21.56 12.05 17 48618 136359 110404305
Disease progression 21.55 12.05 47 48588 243987 110296677
Loss of consciousness 21.51 12.05 154 48481 196152 110344512
Renal artery restenosis 21.38 12.05 4 48631 12 110540652
Urinary incontinence 21.30 12.05 58 48577 48529 110492135
Peripheral coldness 21.30 12.05 33 48602 18507 110522157
Failure to suspend medication 21.19 12.05 8 48627 478 110540186
Nail pitting 21.16 12.05 8 48627 480 110540184
Haemoglobin increased 21.13 12.05 23 48612 9124 110531540
Gravitational oedema 20.82 12.05 12 48623 1886 110538778
Bundle branch block left 20.82 12.05 27 48608 12861 110527803
Atrioventricular block 20.74 12.05 31 48604 16846 110523818
Retinal detachment 20.72 12.05 25 48610 11075 110529589
Vascular resistance systemic 20.69 12.05 4 48631 15 110540649
Nail injury 20.39 12.05 9 48626 804 110539860
Gastrointestinal ischaemia 20.36 12.05 8 48627 533 110540131
Injection site erythema 20.27 12.05 8 48627 94168 110446496
Toxicity to various agents 20.25 12.05 126 48509 480429 110060235
Diabetes mellitus inadequate control 20.05 12.05 42 48593 29733 110510931
Duodenal ulcer 20.03 12.05 33 48602 19481 110521183
Erectile dysfunction 19.89 12.05 32 48603 18524 110522140
Tumour invasion 19.81 12.05 8 48627 573 110540091
Pemphigoid 19.79 12.05 33 48602 19674 110520990
Glycosylated haemoglobin decreased 19.79 12.05 9 48626 863 110539801
Hypovolaemic shock 19.69 12.05 28 48607 14555 110526109
Blood electrolytes abnormal 19.66 12.05 12 48623 2096 110538568
Prescribed overdose 19.59 12.05 7 48628 87574 110453090
Intention tremor 19.57 12.05 9 48626 885 110539779
Nasopharyngitis 19.55 12.05 98 48537 394263 110146401
Pyrexia 19.50 12.05 278 48357 897987 109642677
Heart rate decreased 19.42 12.05 80 48555 82676 110457988
Transplant dysfunction 19.34 12.05 21 48614 8307 110532357
Blood pressure systolic increased 19.30 12.05 80 48555 82911 110457753
Rash maculo-papular 19.23 12.05 74 48561 74148 110466516
Consciousness fluctuating 19.20 12.05 12 48623 2184 110538480
Cough 19.10 12.05 297 48338 461344 110079320
Mental status changes 18.98 12.05 5 48630 76117 110464547
Ventricular extrasystoles 18.96 12.05 35 48600 22606 110518058
Psychomotor retardation 18.71 12.05 20 48615 7772 110532892
Depressed mood 18.61 12.05 64 48571 60745 110479919
Pancreatic neoplasm 18.58 12.05 11 48624 1818 110538846
Hypertensive crisis 18.34 12.05 36 48599 24336 110516328
Haematoma 18.29 12.05 62 48573 58414 110482250
Nasal mucosal disorder 18.28 12.05 11 48624 1872 110538792
Paramnesia 18.14 12.05 4 48631 32 110540632
Drug level increased 18.03 12.05 54 48581 47665 110492999
Ventricular flutter 18.02 12.05 5 48630 110 110540554
Product prescribing issue 17.95 12.05 25 48610 12747 110527917
Gingival hypertrophy 17.86 12.05 15 48620 4316 110536348
Helicobacter infection 17.79 12.05 33 48602 181844 110358820
Proteinuria 17.77 12.05 48 48587 39970 110500694
Sleep disorder 17.75 12.05 38 48597 198606 110342058
Hyperlactacidaemia 17.70 12.05 20 48615 8266 110532398
Urine albumin/creatinine ratio increased 17.70 12.05 9 48626 1104 110539560
Stevens-Johnson syndrome 17.66 12.05 53 48582 46848 110493816
Peripheral artery haematoma 17.57 12.05 5 48630 121 110540543
Carotid artery stenosis 17.52 12.05 21 48614 9242 110531422
Mucocutaneous haemorrhage 17.21 12.05 6 48629 285 110540379
Bundle branch block right 17.19 12.05 24 48611 12267 110528397
Arterial stenosis 17.14 12.05 10 48625 1609 110539055
Labelled drug-drug interaction medication error 17.08 12.05 39 48596 29263 110511401
Blood glucose increased 16.94 12.05 108 48527 132388 110408276
Food interaction 16.93 12.05 11 48624 2141 110538523
Anaemia megaloblastic 16.89 12.05 8 48627 841 110539823
Chronic gastritis 16.87 12.05 16 48619 5395 110535269
Urinary retention 16.86 12.05 68 48567 69615 110471049
Liver injury 16.84 12.05 25 48610 150388 110390276
Fatigue 16.82 12.05 407 48228 1215551 109325113
Urine glucose/creatinine ratio increased 16.81 12.05 5 48630 142 110540522
Stenosis 16.78 12.05 13 48622 3338 110537326
Platelet count decreased 16.76 12.05 49 48586 230394 110310270
Hospitalisation 16.63 12.05 23 48612 142470 110398194
Sciatica 16.62 12.05 10 48625 92389 110448275
Vertigo 16.62 12.05 79 48556 86791 110453873
Liver disorder 16.56 12.05 23 48612 142220 110398444
Melaena 16.56 12.05 67 48568 68690 110471974
Renal pain 16.54 12.05 21 48614 9796 110530868
Hypouricaemia 16.46 12.05 7 48628 571 110540093
Incorrect route of product administration 16.37 12.05 4 48631 64057 110476607
Hyperhidrosis 16.14 12.05 139 48496 187159 110353505
Heart rate irregular 16.12 12.05 42 48593 34232 110506432
Gingival hypoplasia 16.03 12.05 3 48632 9 110540655
Spinal pain 15.98 12.05 29 48606 18486 110522178
Colitis ulcerative 15.96 12.05 7 48628 77356 110463308
Periorbital oedema 15.92 12.05 21 48614 10171 110530493
Renal mass 15.85 12.05 13 48622 3622 110537042
Catheter site thrombosis 15.84 12.05 7 48628 627 110540037
Oedema genital 15.76 12.05 7 48628 635 110540029
Depression 15.64 12.05 79 48556 317256 110223408
Thrombocytosis 15.52 12.05 21 48614 10423 110530241
Polydipsia 15.48 12.05 18 48617 7670 110532994
Lung neoplasm malignant 15.44 12.05 41 48594 33801 110506863
Postural tremor 15.34 12.05 8 48627 1034 110539630
Convulsive threshold lowered 15.31 12.05 8 48627 1038 110539626
Renal artery arteriosclerosis 15.23 12.05 4 48631 71 110540593
Ejection fraction decreased 15.20 12.05 46 48589 40834 110499830
Congenital methaemoglobinaemia 15.17 12.05 4 48631 72 110540592
Blood creatine phosphokinase increased 15.12 12.05 68 48567 73009 110467655
Mouth ulceration 15.02 12.05 51 48584 48087 110492577
COVID-19 pneumonia 14.96 12.05 43 48592 37100 110503564
Product monitoring error 14.89 12.05 19 48616 8908 110531756
Anuria 14.86 12.05 33 48602 24308 110516356
Skin wound 14.60 12.05 10 48625 2124 110538540
Urine output decreased 14.52 12.05 29 48606 19847 110520817
Musculoskeletal discomfort 14.47 12.05 32 48603 23506 110517158
Polyuria 14.33 12.05 27 48608 17711 110522953
Pseudogynaecomastia 14.21 12.05 4 48631 93 110540571
Protrusion tongue 14.20 12.05 6 48629 482 110540182
Therapeutic response decreased 14.07 12.05 13 48622 96486 110444178
Ear infection 14.05 12.05 5 48630 62727 110477937
Resting tremor 14.03 12.05 9 48626 1714 110538950
Vision blurred 14 12.05 101 48534 128921 110411743
Blood lactic acid increased 13.94 12.05 25 48610 15796 110524868
Frequent bowel movements 13.90 12.05 7 48628 71383 110469281
Platelet dysfunction 13.84 12.05 6 48629 513 110540151
Blood urine present 13.84 12.05 32 48603 24213 110516451
Weight increased 13.82 12.05 118 48517 419526 110121138
Fear of eating 13.74 12.05 6 48629 522 110540142
Angina pectoris 13.67 12.05 59 48576 62236 110478428
Osteoporosis 13.60 12.05 11 48624 87141 110453523
Hepatitis D 13.60 12.05 4 48631 109 110540555
Pancytopenia 13.54 12.05 47 48588 209566 110331098
Blood bilirubin abnormal 13.45 12.05 9 48626 1841 110538823
Pregnancy 13.42 12.05 3 48632 51064 110489600
Gallbladder disorder 13.40 12.05 29 48606 21000 110519664
Arteriosclerosis 13.38 12.05 32 48603 24735 110515929
Night sweats 13.38 12.05 24 48611 133959 110406705
Blood potassium decreased 13.24 12.05 53 48582 54061 110486603
Pancreatitis acute 13.16 12.05 57 48578 60217 110480447
Gastric ulcer 13.14 12.05 43 48592 39784 110500880
Multiple sclerosis relapse 13.11 12.05 3 48632 50237 110490427
External ear pain 13.10 12.05 3 48632 29 110540635
Wound infection 12.91 12.05 14 48621 96451 110444213
Hyperuricaemia 12.85 12.05 23 48612 14508 110526156
Thirst 12.77 12.05 29 48606 21678 110518986
Blister 12.75 12.05 54 48581 227322 110313342
Coronary artery occlusion 12.73 12.05 24 48611 15748 110524916
Gastrointestinal disorder 12.64 12.05 59 48576 241893 110298771
Postoperative hypertension 12.59 12.05 3 48632 35 110540629
Cardiac failure 12.56 12.05 132 48503 187494 110353170
Ear disorder 12.54 12.05 13 48622 4876 110535788
Plasma cell myeloma 12.51 12.05 6 48629 62930 110477734
Hypoparathyroidism 12.48 12.05 8 48627 1522 110539142
Drug level above therapeutic 12.44 12.05 20 48615 11568 110529096
Hypocalciuria 12.44 12.05 3 48632 37 110540627
Acute myocardial infarction 12.43 12.05 71 48564 83706 110456958
Epistaxis 12.43 12.05 99 48536 130273 110410391
Ephelides 12.41 12.05 4 48631 149 110540515
Parkinsonian gait 12.36 12.05 7 48628 1065 110539599
Ventricular tachycardia 12.25 12.05 49 48586 49960 110490704
Lipase increased 12.18 12.05 26 48609 18646 110522018
Angle closure glaucoma 12.18 12.05 11 48624 3488 110537176
Brain stem haematoma 12.14 12.05 4 48631 160 110540504
Vasoconstriction 12.13 12.05 7 48628 1103 110539561
Injection site swelling 12.12 12.05 6 48629 61784 110478880
Hyperlipidaemia 12.10 12.05 39 48596 35809 110504855

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03BA11 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, EXCL. THIAZIDES
Sulfonamides, plain
ATC C09BX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DX09 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C10BX13 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA PE N0000175359 Increased Diuresis
FDA EPC N0000175420 Thiazide-like Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D045283 Natriuretic Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D049993 Sodium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35498 diuretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent

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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Edema indication 267038008
Anuria contraindication 2472002 DOID:2983
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hyperparathyroidism contraindication 66999008 DOID:13543
Diabetes mellitus contraindication 73211009 DOID:9351
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.53 acidic
pKa2 9.54 acidic
pKa3 5.52 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 2.5MG BASE;1.25MG;20MG WIDAPLIK AZURITY N219423 June 5, 2025 DISCN TABLET ORAL 10799487 Jan. 23, 2038 A METHOD OF TREATING HYPERTENSION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 1.25MG BASE;0.625MG;10MG WIDAPLIK AZURITY N219423 June 5, 2025 DISCN TABLET ORAL June 5, 2028 NEW PRODUCT
EQ 2.5MG BASE;1.25MG;20MG WIDAPLIK AZURITY N219423 June 5, 2025 DISCN TABLET ORAL June 5, 2028 NEW PRODUCT
EQ 5MG BASE;2.5MG;40MG WIDAPLIK AZURITY N219423 June 5, 2025 DISCN TABLET ORAL June 5, 2028 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 12 member 3 Transporter INHIBITOR A2 7.54 WOMBAT-PK CHEMBL
Carbonic anhydrase 2 Enzyme Kd 6.70 CHEMBL
Carbonic anhydrase 1 Enzyme Kd 5 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.67 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 7.44 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 8 CHEMBL
Potassium voltage-gated channel subfamily KQT member 1 Ion channel WOMBAT-PK
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.05 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.56 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 9.64 CHEMBL
Carbonic anhydrase 6 Enzyme Kd 6.60 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 5.31 CHEMBL
Carbonic anhydrase 13 Enzyme Kd 7 CHEMBL
Carbonic anhydrase 3 Enzyme Kd 4.96 CHEMBL
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D Enzyme ALLOSTERIC MODULATOR Kd 6.24 IUPHAR
Arachidonate 15-lipoxygenase Enzyme IC50 5.54 DRUG MATRIX
Carbonic anhydrase 13 Enzyme Ki 7.89 CHEMBL

External reference:

IDSource
4018746 VUID
N0000147050 NUI
D00345 KEGG_DRUG
180004-24-4 SECONDARY_CAS_RN
4018746 VANDF
C0021186 UMLSCUI
CHEBI:5893 CHEBI
BL1 PDB_CHEM_ID
CHEMBL406 ChEMBL_ID
DB00808 DRUGBANK_ID
D007190 MESH_DESCRIPTOR_UI
3702 PUBCHEM_CID
7203 IUPHAR_LIGAND_ID
3333 INN_ID
F089I0511L UNII
5764 RXNORM
2360 MMSL
4873 MMSL
d00260 MMSL
002313 NDDF
387419003 SNOMEDCT_US
725661001 SNOMEDCT_US
74213004 SNOMEDCT_US
F089I0511L INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2571 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2571 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2597 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 0228-2597 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide Human Prescription Drug Label 1 16571-875 TABLET 1.25 mg ORAL ANDA 18 sections
Indapamide Human Prescription Drug Label 1 16571-876 TABLET 2.50 mg ORAL ANDA 18 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 21695-576 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
WIDAPLIK Human Prescription Drug Label 3 24338-001 TABLET 0.63 mg ORAL NDA 27 sections
WIDAPLIK Human Prescription Drug Label 3 24338-002 TABLET 1.25 mg ORAL NDA 27 sections
WIDAPLIK Human Prescription Drug Label 3 24338-003 TABLET 2.50 mg ORAL NDA 27 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 50090-7826 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 50090-7828 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 51407-024 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 51407-025 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 62559-510 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 62559-511 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1953 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1953 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1954 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 63629-1954 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 68151-1294 TABLET, FILM COATED 1.25 mg ORAL ANDA 20 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 68788-7247 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 71335-1541 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 72162-1766 TABLET, FILM COATED 1.25 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 72162-1767 TABLET, FILM COATED 2.50 mg ORAL ANDA 19 sections
Indapamide HUMAN PRESCRIPTION DRUG LABEL 1 72189-591 TABLET, FILM COATED 2.50 mg ORAL ANDA 12 sections