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clopamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diuretics, sulfamoylbenzoic acid derivatives | 706 | 636-54-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A sulfamoylbenzamide piperidine. It is considered a thiazide-like diuretic.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
| BA (Bioavailability) | 85 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,PDK1,PDK2,PDK4,PRKDC | 12 | |||
| kinase-selectivity-class | AXL,BRAF,EIF2AK3,GRK2,MAP2K6,PDK1 | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C03BA03 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, EXCL. THIAZIDES Sulfonamides, plain |
| ATC | C03BB03 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, EXCL. THIAZIDES Sulfonamides and potassium in combination |
| MeSH PA | D004232 | Diuretics |
| MeSH PA | D045283 | Natriuretic Agents |
Related Drugs by ATC class:
C03BA Sulfonamides, plain 10 drugs
C03BB Sulfonamides and potassium in combination 4 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.61 | acidic |
| pKa2 | 11.42 | acidic |
| pKa3 | 3.76 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167202 | NUI |
| D02460 | KEGG_DRUG |
| 2603 | RXNORM |
| C0009025 | UMLSCUI |
| CHEBI:94521 | CHEBI |
| CHEMBL1605650 | ChEMBL_ID |
| DB13792 | DRUGBANK_ID |
| D003005 | MESH_DESCRIPTOR_UI |
| 12492 | PUBCHEM_CID |
| 1517 | INN_ID |
| 17S83WON0I | UNII |
| 003711 | NDDF |
| 395940005 | SNOMEDCT_US |
| 429462003 | SNOMEDCT_US |
Pharmaceutical products:
None