hydrochlorothiazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 1385 58-93-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrochlorothiazide
  • hydrochlorothiazid
  • hydrochlorthiazide
  • hydrochlorzide
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
  • Molecular weight: 297.73
  • Formula: C7H8ClN3O4S2
  • CLOGP: -0.36
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -2.12
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O
25 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.72 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 100 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.18 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.56 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Feb. 12, 1959 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1225.56 9.85 1786 236089 110114 63141033
Pemphigus 616.93 9.85 15 237860 183711 63067436
Maternal exposure during pregnancy 538.52 9.85 89 237786 219973 63031174
Hypokalaemia 529.96 9.85 1189 236686 102615 63148532
Hand deformity 487.51 9.85 27 237848 159430 63091717
Systemic lupus erythematosus 469.81 9.85 104 237771 208814 63042333
Glossodynia 445.09 9.85 69 237806 178807 63072340
Contraindicated product administered 345.16 9.85 193 237682 217455 63033692
Synovitis 322.93 9.85 148 237727 186770 63064377
Off label use 321.10 9.85 1370 236505 673092 62578055
Acute kidney injury 312.39 9.85 1868 236007 261547 62989600
Duodenal ulcer perforation 301.07 9.85 5 237870 87204 63163943
Blood pressure increased 298.62 9.85 1301 236574 160761 63090386
Pericarditis 279.02 9.85 74 237801 131505 63119642
Treatment failure 276.64 9.85 205 237670 198838 63052309
Exposure during pregnancy 273.60 9.85 120 237755 155427 63095720
Wound 271.69 9.85 136 237739 163127 63088020
Drug intolerance 265.18 9.85 469 237406 308192 62942955
Alopecia 243.03 9.85 568 237307 336968 62914179
Myocardial infarction 240.34 9.85 872 237003 99021 63152126
Blood potassium decreased 237.75 9.85 502 237373 41524 63209623
Arthropathy 228.75 9.85 328 237547 234464 63016683
Drug ineffective 226.22 9.85 2670 235205 1042095 62209052
Cerebrovascular accident 222.10 9.85 897 236978 107127 63144020
Discomfort 217.90 9.85 184 237691 167190 63083957
Lower respiratory tract infection 208.65 9.85 118 237757 132189 63118958
Angioedema 206.10 9.85 514 237361 47451 63203696
Rheumatoid factor positive 189.61 9.85 42 237833 84364 63166783
Dehydration 178.24 9.85 1186 236689 172168 63078979
Muscle injury 177.37 9.85 19 237856 65326 63185821
Folliculitis 175.07 9.85 27 237848 70290 63180857
Helicobacter infection 173.82 9.85 65 237810 92720 63158427
Macular degeneration 162.73 9.85 312 237563 24064 63227083
Sleep disorder due to general medical condition, insomnia type 162.14 9.85 8 237867 52209 63198938
Abdominal discomfort 161.96 9.85 636 237239 320249 62930898
Product use issue 161.85 9.85 367 237508 220153 63030994
Dizziness 159.56 9.85 2376 235499 427549 62823598
Coronary artery disease 157.40 9.85 364 237511 32013 63219134
Syncope 151.55 9.85 852 237023 116533 63134614
Infusion related reaction 150.04 9.85 448 237427 245073 63006074
Swelling 149.91 9.85 529 237346 274849 62976298
Blood pressure inadequately controlled 144.99 9.85 132 237743 4846 63246301
Eosinophilic bronchitis 141.97 9.85 60 237815 513 63250634
Therapeutic product effect decreased 141.34 9.85 322 237553 192865 63058282
Joint swelling 138.41 9.85 694 237181 326972 62924175
Inappropriate antidiuretic hormone secretion 135.57 9.85 223 237652 15239 63235908
Condition aggravated 131.73 9.85 924 236951 401293 62849854
Blister 130.66 9.85 177 237698 129637 63121510
Infection 129.59 9.85 433 237442 228740 63022407
Irritable bowel syndrome 127.76 9.85 75 237800 82337 63168810
Lactic acidosis 124.14 9.85 370 237505 37917 63213230
Transient ischaemic attack 121.61 9.85 364 237511 37389 63213758
Hepatic enzyme increased 119.43 9.85 375 237500 201953 63049194
Fall 116.30 9.85 2090 235785 390244 62860903
Hypotension 113.91 9.85 1539 236336 271065 62980082
Blood glucose increased 111.45 9.85 613 237262 83143 63168004
Asthenia 108.96 9.85 2030 235845 381574 62869573
Gastrooesophageal reflux disease 107.21 9.85 669 237206 94970 63156177
Drug abuse 106.85 9.85 70 237805 72448 63178699
Impaired healing 104.00 9.85 139 237736 102403 63148744
Abortion spontaneous 99.13 9.85 27 237848 47168 63203979
Product use in unapproved indication 93.41 9.85 350 237525 178730 63072417
Blood sodium decreased 90.92 9.85 247 237628 24005 63227142
Sprue-like enteropathy 88.63 9.85 47 237828 696 63250451
Mobility decreased 84.53 9.85 207 237668 120952 63130195
Death 84.50 9.85 946 236929 373435 62877712
Palpitations 83.83 9.85 715 237160 112055 63139092
Intentional product use issue 82.71 9.85 227 237648 127665 63123482
Hypertension 80.91 9.85 1483 236392 277820 62973327
Renal failure 80.75 9.85 733 237142 116919 63134228
Hip arthroplasty 80.23 9.85 39 237836 47607 63203540
Chest pain 79.64 9.85 1193 236682 214766 63036381
Live birth 79.33 9.85 4 237871 25626 63225521
Lung diffusion test abnormal 78.66 9.85 34 237841 309 63250838
Cardiac failure congestive 77.86 9.85 603 237272 91830 63159317
Hypertensive crisis 77.77 9.85 175 237700 15111 63236036
Oedema peripheral 77.47 9.85 1066 236809 188445 63062702
Hypersensitivity 76.97 9.85 713 237162 291972 62959175
Stomatitis 76.38 9.85 265 237610 138460 63112687
C-reactive protein abnormal 74.24 9.85 40 237835 46056 63205091
Hypochloraemia 74.17 9.85 61 237814 1948 63249199
Pain 73.86 9.85 2163 235712 738465 62512682
Pregnancy 73.83 9.85 23 237852 36813 63214334
Ill-defined disorder 73.00 9.85 121 237754 81634 63169513
Rash 71.98 9.85 1578 236297 559293 62691854
Therapy non-responder 71.88 9.85 108 237767 75793 63175354
Angina pectoris 70.94 9.85 261 237614 29817 63221330
Blood urea increased 70.92 9.85 239 237636 26140 63225007
Intentional self-injury 70.91 9.85 7 237868 25680 63225467
Pancreatitis acute 69.42 9.85 242 237633 26924 63224223
Liver injury 65.56 9.85 78 237797 60442 63190705
Cardiospasm 64.40 9.85 55 237820 1852 63249295
Psoriatic arthropathy 64.11 9.85 156 237719 91364 63159783
Polyp 63.97 9.85 99 237776 6422 63244725
Drug interaction 63.68 9.85 1209 236666 227922 63023225
Atrial tachycardia 63.61 9.85 79 237796 4161 63246986
Hypovolaemia 63.27 9.85 130 237745 10543 63240604
Palmoplantar keratoderma 61.96 9.85 55 237820 1952 63249195
Blood pressure diastolic decreased 61.28 9.85 206 237669 22500 63228647
Loss of employment 60.51 9.85 57 237818 2187 63248960
Gastrointestinal disorder 59.36 9.85 271 237604 130968 63120179
Product complaint 57.90 9.85 140 237735 12669 63238478
Myelosuppression 56.98 9.85 10 237865 23693 63227454
Hypertensive emergency 56.97 9.85 51 237824 1831 63249316
Hyperkalaemia 56.91 9.85 373 237502 53830 63197317
Blood creatinine increased 56.59 9.85 540 237335 87304 63163843
Hypoglycaemia 56.33 9.85 402 237473 59663 63191484
Nausea 55.81 9.85 3813 234062 850658 62400489
Red blood cell sedimentation rate abnormal 55.65 9.85 5 237870 19777 63231370
Febrile neutropenia 55.13 9.85 242 237633 118207 63132940
Carotid artery occlusion 54.30 9.85 77 237798 4617 63246530
Atrial fibrillation 54.29 9.85 672 237203 115964 63135183
Pruritus genital 54.23 9.85 58 237817 2596 63248551
Blood pressure systolic increased 52.12 9.85 330 237545 47067 63204080
Neutropenia 51.45 9.85 414 237461 174591 63076556
Sinus bradycardia 51.37 9.85 145 237730 14406 63236741
Disease progression 51.15 9.85 261 237614 122497 63128650
Sleep terror 50.29 9.85 56 237819 2624 63248523
Cytomegalovirus infection 50.02 9.85 9 237866 20943 63230204
Disorientation 49.31 9.85 284 237591 39168 63211979
Angina unstable 48.81 9.85 92 237783 7003 63244144
Toxicity to various agents 48.76 9.85 643 237232 246607 63004540
Diabetes mellitus 47.48 9.85 365 237510 55445 63195702
Malignant neoplasm progression 47.15 9.85 154 237721 81967 63169180
Arterial occlusive disease 47.02 9.85 82 237793 5876 63245271
Recalled product 46.44 9.85 40 237835 1363 63249784
Drug resistance 44.75 9.85 15 237860 22918 63228229
Cataract 44.64 9.85 366 237509 56687 63194460
Feeling abnormal 44.33 9.85 792 237083 147600 63103547
Musculoskeletal stiffness 44.17 9.85 460 237415 184158 63066989
Hypercalcaemia 42.96 9.85 215 237660 28107 63223040
Anosmia 42.38 9.85 85 237790 6775 63244372
Premature delivery 42.25 9.85 31 237844 30250 63220897
Tension headache 41.74 9.85 72 237803 5114 63246033
Neutrophil count decreased 40.41 9.85 95 237780 56311 63194836
Hepatic function abnormal 40.09 9.85 48 237827 37094 63214053
Fibromyalgia 40.08 9.85 160 237715 80260 63170887
Facial pain 40.02 9.85 108 237767 10453 63240694
Immunisation 39.46 9.85 34 237841 1159 63249988
Milk-alkali syndrome 38.92 9.85 29 237846 799 63250348
Large intestine polyp 38.86 9.85 91 237784 8066 63243081
Pneumonia aspiration 38.29 9.85 241 237634 34299 63216848
Intentional overdose 37.93 9.85 146 237729 74006 63177141
Hyperlipidaemia 37.41 9.85 159 237716 19412 63231735
Neutrophilia 36.56 9.85 62 237813 4344 63246803
Hospitalisation 36.52 9.85 179 237696 84902 63166245
Pancreatitis 36.41 9.85 311 237564 48744 63202403
Peripheral swelling 36.39 9.85 740 237135 265202 62985945
Ventricular hypertrophy 36.30 9.85 54 237821 3382 63247765
Nasopharyngitis 35.84 9.85 704 237171 253553 62997594
Subarachnoid haemorrhage 35.42 9.85 126 237749 14157 63236990
Rheumatoid arthritis 35.11 9.85 705 237170 253114 62998033
Prescribed overdose 34.91 9.85 46 237829 34107 63217040
Obstructive airways disorder 34.90 9.85 162 237713 20537 63230610
Allergic oedema 34.52 9.85 27 237848 801 63250346
Hyperhidrosis 34.52 9.85 582 237293 107254 63143893
Pyrexia 34.46 9.85 1427 236448 469051 62782096
Conjoined twins 34.21 9.85 18 237857 262 63250885
Pemphigoid 33.98 9.85 81 237794 7263 63243884
Heart rate irregular 33.86 9.85 170 237705 22251 63228896
Gastric disorder 33.82 9.85 248 237627 37121 63214026
Hepatic steatosis 33.31 9.85 203 237672 28566 63222581
Weight decreased 33.04 9.85 1309 236566 275489 62975658
Sedation complication 32.86 9.85 6 237869 13816 63237331
Bradycardia 32.40 9.85 418 237457 72809 63178338
Cough 32.33 9.85 1373 236502 291370 62959777
Blood chloride decreased 32.26 9.85 67 237808 5475 63245672
Rhabdomyolysis 31.76 9.85 277 237598 43674 63207473
Arrhythmia 31.64 9.85 248 237627 37892 63213255
Mitral valve incompetence 31.32 9.85 151 237724 19443 63231704
Adverse drug reaction 31.24 9.85 173 237702 79541 63171606
Intestinal angioedema 30.92 9.85 23 237852 632 63250515
Device expulsion 30.87 9.85 52 237823 34870 63216277
Leukopenia 30.69 9.85 167 237708 77123 63174024
Swollen tongue 30.39 9.85 229 237646 34571 63216576
Product monitoring error 30.38 9.85 58 237817 4458 63246689
Pneumonia 29.82 9.85 1403 236472 455364 62795783
Knee arthroplasty 29.51 9.85 104 237771 54102 63197045
Atrioventricular block first degree 29.21 9.85 76 237799 7197 63243950
Acute myeloid leukaemia 28.92 9.85 14 237861 17133 63234014
Mental status changes 28.83 9.85 250 237625 39349 63211798
Arteriosclerosis 28.66 9.85 93 237782 9973 63241174
Myalgia 28.53 9.85 735 237140 145794 63105353
Anxiety 28.14 9.85 1038 236837 216503 63034644
Electrolyte imbalance 28.08 9.85 149 237726 19927 63231220
Device related thrombosis 27.98 9.85 34 237841 1751 63249396
Foetal death 27.82 9.85 4 237871 10976 63240171
Muscle spasms 27.75 9.85 774 237101 155376 63095771
Blood creatine phosphokinase increased 27.57 9.85 202 237673 30228 63220919
Electrocardiogram abnormal 27.22 9.85 86 237789 9093 63242054
Essential hypertension 27.16 9.85 59 237816 4974 63246173
Joint range of motion decreased 27.12 9.85 50 237825 32378 63218769
Product prescribing error 27.04 9.85 180 237695 26109 63225038
Rotator cuff syndrome 26.82 9.85 111 237764 13391 63237756
Suicide attempt 26.81 9.85 127 237748 60791 63190356
Gangrene 26.69 9.85 66 237809 6057 63245090
Haemophagocytic lymphohistiocytosis 26.63 9.85 4 237871 10623 63240524
Bone marrow failure 26.46 9.85 43 237832 29247 63221900
Poisoning deliberate 26.39 9.85 5 237870 11213 63239934
Ventricular extrasystoles 26.38 9.85 100 237775 11587 63239560
Supraventricular extrasystoles 26.15 9.85 55 237820 4534 63246613
Product substitution issue 26.10 9.85 124 237751 15872 63235275
Carotid artery stenosis 26.09 9.85 59 237816 5111 63246036
Congenital bladder anomaly 25.87 9.85 13 237862 171 63250976
Respiratory tract inflammation 25.84 9.85 20 237855 584 63250563
Erythrodermic psoriasis 25.82 9.85 25 237850 993 63250154
Depression 25.52 9.85 938 236937 195554 63055593
Withdrawal hypertension 25.45 9.85 12 237863 136 63251011
Coma 25.43 9.85 360 237515 64004 63187143
Urachal abnormality 25.35 9.85 13 237862 179 63250968
Sepsis 25.02 9.85 413 237462 152710 63098437
Persistent cloaca 24.54 9.85 13 237862 192 63250955
Non-cardiogenic pulmonary oedema 24.52 9.85 21 237854 710 63250437
Systemic infection 24.43 9.85 54 237821 4606 63246541
Foetal exposure during pregnancy 24.39 9.85 52 237823 31910 63219237
Chronic sinusitis 24.28 9.85 104 237771 12739 63238408
Sinusitis 24.20 9.85 655 237220 225998 63025149
Cardiac disorder 24.16 9.85 294 237581 50522 63200625
Emotional distress 23.96 9.85 206 237669 32343 63218804
Insomnia 23.84 9.85 1010 236865 214242 63036905
Nervousness 23.83 9.85 198 237677 30781 63220366
Abnormal dreams 23.75 9.85 90 237785 10426 63240721
Breast cancer stage III 23.66 9.85 5 237870 10381 63240766
Platelet count decreased 23.59 9.85 300 237575 115822 63135325
C-reactive protein increased 23.45 9.85 234 237641 94473 63156674
Hyperglycaemia 23.40 9.85 250 237625 41617 63209530
Visual acuity reduced 23.39 9.85 151 237724 21675 63229472
Anhedonia 23.22 9.85 92 237783 10882 63240265
Heart rate decreased 23.16 9.85 267 237608 45293 63205854
Neurosensory hypoacusis 23.14 9.85 13 237862 217 63250930
Hypersensitivity vasculitis 23.10 9.85 49 237826 4063 63247084
Diabetes mellitus inadequate control 23.06 9.85 115 237760 15011 63236136
Hepatotoxicity 23.00 9.85 67 237808 36974 63214173
Nephrocalcinosis 22.81 9.85 24 237851 1054 63250093
Grip strength decreased 22.80 9.85 30 237845 22257 63228890
Urinary incontinence 22.73 9.85 201 237674 31813 63219334
Rhinalgia 22.73 9.85 29 237846 1570 63249577
Bundle branch block left 22.67 9.85 68 237807 6991 63244156
Hypocalcaemia 22.46 9.85 199 237676 31514 63219633
Blood pressure decreased 22.31 9.85 355 237520 64667 63186480
Oropharyngeal swelling 22.21 9.85 22 237853 899 63250248
Intestinal villi atrophy 22.13 9.85 13 237862 237 63250910
Atrioventricular block 22.09 9.85 71 237804 7576 63243571
Myocardial ischaemia 21.95 9.85 101 237774 12758 63238389
Tinnitus 21.94 9.85 217 237658 35411 63215736
Facet joint syndrome 21.90 9.85 9 237866 12129 63239018
Diverticulum 21.83 9.85 96 237779 11895 63239252
Coronary artery occlusion 21.82 9.85 74 237801 8117 63243030
Psoriasis 21.82 9.85 452 237423 86505 63164642
Intestinal malrotation 21.75 9.85 15 237860 365 63250782
Type 2 diabetes mellitus 21.67 9.85 145 237730 63723 63187424
Neutropenic sepsis 21.45 9.85 18 237857 16420 63234727
Dysgeusia 21.24 9.85 268 237607 46442 63204705
Heart rate increased 21.14 9.85 482 237393 93756 63157391
Distributive shock 21.12 9.85 26 237849 1357 63249790
Paraesthesia oral 21.12 9.85 134 237741 19122 63232025
Drug hypersensitivity 21.11 9.85 950 236925 309737 62941410
Gout 21.02 9.85 102 237773 13169 63237978
Overdose 20.96 9.85 304 237571 114774 63136373
Glycosylated haemoglobin increased 20.88 9.85 97 237778 12301 63238846
Somnolence 20.83 9.85 843 237032 177842 63073305
Therapy partial responder 20.75 9.85 7 237868 10651 63240496
Orthostatic intolerance 20.74 9.85 24 237851 1173 63249974
Acute coronary syndrome 20.71 9.85 84 237791 10042 63241105
Electrocardiogram ST segment depression 20.66 9.85 38 237837 2839 63248308
Eosinophilia 20.58 9.85 151 237724 22605 63228542
Dry skin 20.43 9.85 313 237562 56574 63194573
Bronchomalacia 20.37 9.85 12 237863 220 63250927
Interstitial lung disease 20.29 9.85 142 237733 61766 63189381
Pneumothorax spontaneous 20.25 9.85 20 237855 814 63250333
Thrombocytopenia 20.24 9.85 422 237453 150735 63100412
Pancytopenia 20.22 9.85 249 237626 96684 63154463
Blindness 20.20 9.85 145 237730 21554 63229593
Bladder prolapse 20.13 9.85 32 237843 2124 63249023
Micturition disorder 20.12 9.85 35 237840 2503 63248644
Osteonecrosis 20.07 9.85 159 237716 24371 63226776
Adenocarcinoma 19.98 9.85 38 237837 2912 63248235
Premature labour 19.91 9.85 11 237864 12493 63238654
Epilepsy 19.85 9.85 45 237830 27020 63224127
Septic shock 19.85 9.85 157 237718 66472 63184675
Hypoparathyroidism 19.79 9.85 18 237857 660 63250487
Cutaneous lupus erythematosus 19.70 9.85 36 237839 2676 63248471
Device related infection 19.62 9.85 36 237839 23356 63227791
Sopor 19.59 9.85 33 237842 22131 63229016
Intervertebral disc protrusion 19.57 9.85 154 237721 23555 63227592
Hypophagia 19.55 9.85 191 237684 31068 63220079
Cholelithiasis 19.54 9.85 251 237624 43674 63207473
Coronary artery stenosis 19.49 9.85 50 237825 4694 63246453
Azotaemia 19.28 9.85 48 237827 4423 63246724
Bacterial infection 19.15 9.85 132 237743 19367 63231780
Metabolic alkalosis 18.99 9.85 38 237837 3023 63248124
Diplopia 18.98 9.85 153 237722 23575 63227572
Haemodialysis 18.92 9.85 75 237800 8872 63242275
Pain of skin 18.84 9.85 90 237785 11544 63239603
Polymyalgia rheumatica 18.84 9.85 43 237832 3748 63247399
Tooth erosion 18.81 9.85 15 237860 458 63250689
Cardiac stress test abnormal 18.76 9.85 17 237858 620 63250527
Renal artery stenosis 18.75 9.85 29 237846 1880 63249267
Autoimmune disorder 18.75 9.85 22 237853 17155 63233992
Vitamin B1 decreased 18.71 9.85 11 237864 201 63250946
Eye pruritus 18.70 9.85 127 237748 18544 63232603
Ventricular fibrillation 18.64 9.85 91 237784 11776 63239371
Pathological fracture 18.64 9.85 74 237801 8760 63242387
Depressed level of consciousness 18.62 9.85 146 237729 61932 63189215
Disturbance in attention 18.61 9.85 222 237653 37967 63213180
Cyanopsia 18.60 9.85 5 237870 7 63251140
Deep vein thrombosis 18.60 9.85 428 237447 83372 63167775
Dysarthria 18.55 9.85 243 237632 42468 63208679
Amnesia 18.51 9.85 302 237573 55283 63195864
Neurofibrosarcoma 18.51 9.85 10 237865 154 63250993
Liver function test increased 18.50 9.85 62 237813 32749 63218398
Disability 18.46 9.85 25 237850 18322 63232825
Mesenteric panniculitis 18.42 9.85 9 237866 111 63251036
Small cell carcinoma 18.40 9.85 10 237865 156 63250991
Hypertensive heart disease 18.39 9.85 33 237842 2419 63248728
Hip fracture 18.38 9.85 180 237695 29294 63221853
Cytokine release syndrome 18.28 9.85 16 237859 14298 63236849
Sedation 18.22 9.85 79 237796 38730 63212417
Tendon rupture 18.18 9.85 70 237805 8169 63242978
Dysuria 18.18 9.85 200 237675 33538 63217609
Pneumocystis jirovecii pneumonia 18.10 9.85 22 237853 16892 63234255
Acute myocardial infarction 18.04 9.85 192 237683 31932 63219215
Eosinophil count increased 18.04 9.85 85 237790 10843 63240304
Bronchopulmonary aspergillosis 18.02 9.85 5 237870 8630 63242517
Cutaneous T-cell lymphoma 18.01 9.85 24 237851 1356 63249791
Pernicious anaemia 17.94 9.85 17 237858 657 63250490
Transplant rejection 17.88 9.85 9 237866 10771 63240376
Meniscus injury 17.85 9.85 63 237812 7051 63244096
Body height decreased 17.83 9.85 80 237795 9998 63241149
Parkinsonism 17.82 9.85 82 237793 10357 63240790
Asthma 17.79 9.85 614 237261 126947 63124200
Adjustment disorder with depressed mood 17.72 9.85 8 237867 10196 63240951
Forced vital capacity decreased 17.64 9.85 21 237854 1058 63250089
Lip swelling 17.60 9.85 186 237689 30877 63220270
Muscular weakness 17.59 9.85 591 237284 121762 63129385
Diverticulitis 17.57 9.85 226 237649 39331 63211816
Tooth abscess 17.57 9.85 106 237769 14863 63236284
Basal cell carcinoma 17.49 9.85 171 237704 27820 63223327
Fear 17.47 9.85 110 237765 15656 63235491
Hypertensive angiopathy 17.42 9.85 8 237867 85 63251062
Peripheral vascular disorder 17.40 9.85 56 237819 5979 63245168
Fear of injection 17.27 9.85 3 237872 7161 63243986
Lacunar infarction 17.19 9.85 38 237837 3242 63247905
Macular oedema 17.12 9.85 42 237833 3835 63247312
Metastases to fallopian tube 17.07 9.85 7 237868 55 63251092
Skin haemorrhage 17.02 9.85 79 237796 10015 63241132
Skin exfoliation 16.99 9.85 241 237634 42861 63208286
Schizophrenia 16.98 9.85 8 237867 9944 63241203
Diarrhoea 16.90 9.85 2985 234890 712381 62538766
Photosensitivity reaction 16.85 9.85 105 237770 14889 63236258
Hyponatraemic encephalopathy 16.80 9.85 11 237864 245 63250902
Back pain 16.78 9.85 1177 236698 262968 62988179
Osteoarthritis 16.76 9.85 472 237403 94871 63156276
Vulvovaginal burning sensation 16.61 9.85 29 237846 2080 63249067
Rectal prolapse 16.58 9.85 28 237847 1955 63249192
Breast cancer stage II 16.55 9.85 6 237869 8730 63242417
Oesophageal discomfort 16.52 9.85 10 237865 193 63250954
Breath sounds abnormal 16.43 9.85 83 237792 10890 63240257
Endometrial cancer stage I 16.37 9.85 11 237864 256 63250891
Injection site inflammation 16.30 9.85 41 237834 3802 63247345
Adverse event 16.27 9.85 168 237707 67391 63183756
Epstein-Barr virus infection 16.18 9.85 5 237870 8045 63243102
Blood lactic acid decreased 16.09 9.85 9 237866 149 63250998
Meniere's disease 16.08 9.85 10 237865 203 63250944
Petechiae 16.05 9.85 98 237777 13799 63237348
Dementia 16.03 9.85 123 237752 18671 63232476
Bone erosion 16.01 9.85 26 237849 17691 63233456
Acute myopia 15.87 9.85 8 237867 106 63251041
Dystonia 15.85 9.85 17 237858 13802 63237345
Rash papular 15.84 9.85 107 237768 15595 63235552
Anaphylactic reaction 15.67 9.85 165 237710 65935 63185212
Peripheral venous disease 15.66 9.85 21 237854 15456 63235691
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.66 9.85 34 237841 2865 63248282
Vertigo 15.58 9.85 313 237562 59574 63191573
Spinal osteoarthritis 15.56 9.85 109 237766 16077 63235070
Hypertrophic cardiomyopathy 15.44 9.85 24 237851 1563 63249584
Neurotoxicity 15.29 9.85 25 237850 16965 63234182
Mucosal membrane hyperplasia 15.23 9.85 6 237869 42 63251105
Polydipsia 15.10 9.85 38 237837 3526 63247621
Amaurosis fugax 15.09 9.85 13 237862 443 63250704
Ventricular tachycardia 15.00 9.85 127 237748 19852 63231295
Extrasystoles 14.99 9.85 48 237827 5112 63246035
Coronary ostial stenosis 14.95 9.85 7 237868 78 63251069
Cardiac hypertrophy 14.93 9.85 19 237856 1026 63250121
Mandibular mass 14.90 9.85 9 237866 173 63250974
Procalcitonin increased 14.89 9.85 20 237855 1139 63250008
Hypomagnesaemia 14.87 9.85 169 237706 28568 63222579
Dysphagia 14.87 9.85 436 237439 88149 63162998
Jaw disorder 14.85 9.85 49 237826 5300 63245847
Low density lipoprotein increased 14.85 9.85 55 237820 6302 63244845
Carotid bruit 14.84 9.85 16 237859 723 63250424
Renal cyst 14.78 9.85 77 237798 10225 63240922
Hypoparathyroidism secondary 14.76 9.85 6 237869 46 63251101
Torsade de pointes 14.70 9.85 93 237782 13258 63237889
Choroidal effusion 14.61 9.85 13 237862 463 63250684
Neonatal respiratory distress 14.60 9.85 12 237863 383 63250764
Confabulation 14.58 9.85 11 237864 309 63250838
Renal injury 14.56 9.85 72 237803 9367 63241780
Peripheral circulatory failure 14.46 9.85 18 237857 950 63250197
Osmotic demyelination syndrome 14.46 9.85 15 237860 648 63250499
Drug ineffective for unapproved indication 14.42 9.85 72 237803 33991 63217156
Carpal tunnel syndrome 14.42 9.85 130 237745 20687 63230460
Breast neoplasm 14.41 9.85 22 237853 1410 63249737
Device difficult to use 14.39 9.85 16 237859 12780 63238367
Angle closure glaucoma 14.31 9.85 28 237847 2191 63248956
Subacute cutaneous lupus erythematosus 14.28 9.85 31 237844 2612 63248535
Myopathy 14.27 9.85 81 237794 11110 63240037
Chest discomfort 14.27 9.85 525 237350 109444 63141703
Post-anoxic myoclonus 14.25 9.85 5 237870 24 63251123
Lower limb fracture 14.19 9.85 45 237830 24176 63226971
Multiple organ dysfunction syndrome 14.14 9.85 140 237735 56612 63194535
International normalised ratio decreased 14.11 9.85 43 237832 4458 63246689
Crystal arthropathy 14.10 9.85 11 237864 325 63250822
Blood hyposmosis 14.09 9.85 5 237870 25 63251122
Glomerulonephritis rapidly progressive 14.07 9.85 18 237857 977 63250170
Gastroenteritis clostridial 14.01 9.85 14 237861 578 63250569
Cardiac murmur 13.99 9.85 98 237777 14454 63236693
Sleep disorder 13.98 9.85 218 237657 81348 63169799
Dilatation atrial 13.92 9.85 26 237849 1965 63249182
Haematotoxicity 13.87 9.85 9 237866 9367 63241780
Temperature regulation disorder 13.87 9.85 3 237872 6129 63245018
Vaginal flatulence 13.83 9.85 35 237840 3258 63247889
Cardiomegaly 13.77 9.85 113 237762 17501 63233646
Cardiac ventriculogram left 13.77 9.85 3 237872 0 63251147
Renal artery dissection 13.77 9.85 3 237872 0 63251147
Night sweats 13.64 9.85 117 237758 48697 63202450
Abortion induced 13.63 9.85 11 237864 10231 63240916
Respiratory disorder 13.63 9.85 88 237787 38994 63212153
Cytopenia 13.61 9.85 14 237861 11587 63239560
Liver disorder 13.56 9.85 132 237743 53555 63197592
Stupor 13.56 9.85 41 237834 4234 63246913
Gastrointestinal toxicity 13.55 9.85 6 237869 7735 63243412
Pulpitis dental 13.46 9.85 17 237858 911 63250236
Actinic keratosis 13.46 9.85 30 237845 2574 63248573
Intervertebral disc degeneration 13.44 9.85 103 237772 15629 63235518
Therapeutic response unexpected 13.43 9.85 118 237757 18641 63232506
Product residue present 13.41 9.85 39 237836 3940 63247207
Eosinophilia myalgia syndrome 13.39 9.85 4 237871 10 63251137
Left ventricular hypertrophy 13.28 9.85 47 237828 5268 63245879
Osteogenesis imperfecta 13.23 9.85 14 237861 619 63250528
Vision blurred 13.20 9.85 444 237431 91480 63159667
White blood cell count decreased 13.07 9.85 409 237466 138695 63112452
Epileptic encephalopathy 13.07 9.85 10 237865 287 63250860
Coronavirus test positive 13.02 9.85 15 237860 730 63250417
Pollakiuria 13.00 9.85 161 237714 27776 63223371
Orthostatic hypotension 13 9.85 199 237676 35961 63215186
Ultrasound kidney abnormal 12.94 9.85 5 237870 33 63251114
Gastritis 12.92 9.85 204 237671 37099 63214048
Atrioventricular block second degree 12.85 9.85 38 237837 3876 63247271
Accidental exposure to product 12.73 9.85 56 237819 27349 63223798
Blood pressure abnormal 12.70 9.85 99 237776 15099 63236048
Therapeutic product effect incomplete 12.67 9.85 364 237511 124692 63126455
Lipohypertrophy 12.66 9.85 14 237861 651 63250496
Product commingling 12.59 9.85 8 237867 169 63250978
Endometrial hyperplasia 12.57 9.85 16 237859 864 63250283
Chondropathy 12.45 9.85 27 237848 2273 63248874
Osteomyelitis acute 12.37 9.85 9 237866 239 63250908
Blood creatinine abnormal 12.34 9.85 32 237843 3024 63248123
Laryngeal pain 12.31 9.85 41 237834 4457 63246690
Vascular device infection 12.29 9.85 6 237869 7306 63243841
Microalbuminuria 12.28 9.85 11 237864 395 63250752
Endometrial cancer 12.24 9.85 33 237842 3192 63247955
Allergic hepatitis 12.23 9.85 5 237870 39 63251108
Chest wall mass 12.21 9.85 6 237869 75 63251072
Hot flush 12.20 9.85 264 237611 50895 63200252
Product administration error 12.17 9.85 133 237742 22264 63228883
Disseminated intravascular coagulation 12.17 9.85 34 237841 19017 63232130
Unintended pregnancy 12.13 9.85 4 237871 6175 63244972
Non-cardiac chest pain 12.02 9.85 51 237824 6221 63244926
Renal tubular necrosis 12.02 9.85 81 237794 11797 63239350
Lip infection 12.00 9.85 7 237868 126 63251021
Pituitary apoplexy 12.00 9.85 7 237868 126 63251021
Glomerulonephritis 11.91 9.85 23 237852 1783 63249364
Blood creatine increased 11.88 9.85 47 237828 5554 63245593
Procedural complication 11.83 9.85 46 237829 5393 63245754
Rheumatoid factor 11.83 9.85 10 237865 332 63250815
Pharyngeal oedema 11.81 9.85 90 237785 13631 63237516
Ageusia 11.79 9.85 90 237785 13638 63237509
Anaemia postoperative 11.78 9.85 26 237849 2216 63248931
Progressive multifocal leukoencephalopathy 11.76 9.85 19 237856 12952 63238195
Renal impairment 11.75 9.85 423 237452 87932 63163215
Gallbladder disorder 11.72 9.85 115 237760 18727 63232420
Adrenocortical carcinoma 11.71 9.85 5 237870 44 63251103
Gastric atony 11.70 9.85 3 237872 3 63251144
Wound treatment 11.69 9.85 8 237867 192 63250955
Lymphocyte count decreased 11.67 9.85 66 237809 30191 63220956
Upper-airway cough syndrome 11.63 9.85 78 237797 11340 63239807
Diabetic neuropathy 11.63 9.85 37 237838 3927 63247220
Tanning 11.61 9.85 6 237869 84 63251063
Respiratory depression 11.60 9.85 21 237854 13694 63237453
Multiple drug therapy 11.59 9.85 35 237840 3611 63247536
Gait disturbance 11.58 9.85 816 237059 182362 63068785
Gastritis erosive 11.49 9.85 49 237826 5990 63245157
Cutaneous T-cell lymphoma stage I 11.44 9.85 4 237871 19 63251128
Skin pressure mark 11.44 9.85 4 237871 19 63251128
Chronic kidney disease 11.39 9.85 236 237639 45162 63205985
Myelodysplastic syndrome 11.38 9.85 29 237846 16725 63234422
Tremor 11.33 9.85 605 237270 131634 63119513
Memory impairment 11.26 9.85 488 237387 103770 63147377
Vasculitis 11.26 9.85 111 237764 18098 63233049
Encephalitis 11.25 9.85 10 237865 8870 63242277
Nodal rhythm 11.25 9.85 22 237853 1721 63249426
Abdominal panniculectomy 11.25 9.85 3 237872 4 63251143
Diverticulum oesophageal 11.17 9.85 7 237868 144 63251003
Lung disorder 11.15 9.85 165 237710 62096 63189051
Foreign body in reproductive tract 11.13 9.85 14 237861 747 63250400
Hyponatraemic syndrome 11.11 9.85 12 237863 543 63250604
Delayed fontanelle closure 11.11 9.85 4 237871 21 63251126
Device dislocation 11.07 9.85 54 237821 25651 63225496
Macrocytosis 11.06 9.85 27 237848 2458 63248689
Maternal drugs affecting foetus 11.00 9.85 3 237872 5239 63245908
Oesophageal oedema 10.98 9.85 5 237870 52 63251095
Hyperammonaemia 10.97 9.85 3 237872 5229 63245918
Lipoedema 10.90 9.85 9 237866 289 63250858
Dermatitis atopic 10.87 9.85 68 237807 9656 63241491
Oral fibroma 10.82 9.85 5 237870 54 63251093
Vitiligo 10.81 9.85 19 237856 1370 63249777
Chills 10.80 9.85 524 237351 112854 63138293
Muscle twitching 10.78 9.85 117 237758 19551 63231596
Multiple-drug resistance 10.78 9.85 3 237872 5167 63245980
Neuroglycopenia 10.76 9.85 11 237864 467 63250680
Sleep apnoea syndrome 10.73 9.85 161 237714 28972 63222175
Vomiting 10.69 9.85 2311 235564 557306 62693841
Cardiac output increased 10.69 9.85 8 237867 222 63250925
Aphthous ulcer 10.67 9.85 89 237786 13849 63237298
Clostridium difficile infection 10.62 9.85 67 237808 29855 63221292
Retroperitoneal fibrosis 10.62 9.85 9 237866 300 63250847
Hypertrichosis 10.60 9.85 17 237858 1137 63250010
Vascular access site pain 10.58 9.85 6 237869 102 63251045
Non-Hodgkin's lymphoma 10.58 9.85 19 237856 1393 63249754
Adiposis dolorosa 10.51 9.85 9 237866 304 63250843
Iliac artery embolism 10.50 9.85 3 237872 6 63251141
Eczema weeping 10.50 9.85 3 237872 6 63251141
Femoral bruit 10.50 9.85 3 237872 6 63251141
Haemorrhagic fever 10.50 9.85 3 237872 6 63251141
Encephalomalacia 10.47 9.85 11 237864 482 63250665
Thyroid neoplasm 10.44 9.85 36 237839 3983 63247164
Nocturia 10.43 9.85 59 237816 8082 63243065
Fibrosis 10.41 9.85 37 237838 4155 63246992
Paraesthesia 10.41 9.85 702 237173 156264 63094883
Blood potassium abnormal 10.33 9.85 27 237848 2563 63248584
Exposure to toxic agent 10.31 9.85 4 237871 5583 63245564
Prothrombin time abnormal 10.29 9.85 11 237864 492 63250655
Arteriosclerosis coronary artery 10.28 9.85 60 237815 8313 63242834
Antidiuretic hormone abnormality 10.27 9.85 4 237871 27 63251120
Dementia Alzheimer's type 10.27 9.85 16 237859 1044 63250103
Pruritus allergic 10.25 9.85 20 237855 1562 63249585
Immune reconstitution inflammatory syndrome 10.21 9.85 5 237870 6079 63245068
Vulvovaginal pruritus 10.19 9.85 31 237844 3212 63247935
Mouth ulceration 10.16 9.85 77 237798 32907 63218240
Cerebral ischaemia 10.15 9.85 51 237824 6677 63244470
Agranulocytosis 10.14 9.85 54 237821 25080 63226067
Vertebral artery stenosis 10.14 9.85 5 237870 63 63251084
Overweight 10.09 9.85 34 237841 3717 63247430
Endophthalmitis 10.06 9.85 33 237842 3559 63247588
Poor personal hygiene 10.06 9.85 9 237866 323 63250824
Thrombotic microangiopathy 10.02 9.85 15 237860 10546 63240601
Varicose vein ruptured 10.00 9.85 5 237870 65 63251082
Blood pressure systolic abnormal 10.00 9.85 85 237790 13301 63237846
Coma acidotic 10.00 9.85 6 237869 114 63251033
Tricuspid valve incompetence 9.97 9.85 91 237784 14530 63236617
Allergic cough 9.94 9.85 13 237862 721 63250426
Endometrial disorder 9.87 9.85 13 237862 726 63250421
Normal newborn 9.86 9.85 10 237865 8331 63242816

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 458.54 10.35 974 128948 81717 34745292
Angioedema 394.36 10.35 584 129338 36790 34790219
Off label use 295.07 10.35 708 129214 418816 34408193
Hypokalaemia 251.83 10.35 622 129300 57592 34769417
Drug abuse 216.86 10.35 51 129871 99045 34727964
Acute kidney injury 216.68 10.35 1899 128023 303089 34523920
Dizziness 165.00 10.35 1380 128542 217141 34609868
Syncope 155.66 10.35 713 129209 90738 34736271
Cerebrovascular accident 150.90 10.35 670 129252 84141 34742868
Death 150.57 10.35 867 129055 397182 34429827
Coronary artery disease 121.00 10.35 425 129497 47880 34779129
Blood glucose increased 117.82 10.35 526 129396 66192 34760817
Product use in unapproved indication 114.34 10.35 162 129760 117337 34709672
Myocardial infarction 114.23 10.35 806 129116 120279 34706730
Neutropenia 112.47 10.35 261 129661 156517 34670492
Febrile neutropenia 109.69 10.35 214 129708 136635 34690374
Pneumonia 103.22 10.35 858 129064 361769 34465240
Pyrexia 103.09 10.35 770 129152 332243 34494766
Cardiospasm 99.26 10.35 66 129856 1522 34825487
Drug ineffective 97.38 10.35 1159 128763 455592 34371417
Hypotension 96.15 10.35 1251 128671 220398 34606611
Blood pressure inadequately controlled 95.61 10.35 79 129843 2561 34824448
Dehydration 95.31 10.35 816 129106 129153 34697856
Blood pressure increased 94.78 10.35 606 129316 87496 34739513
Carotid artery occlusion 90.23 10.35 89 129833 3648 34823361
Milk-alkali syndrome 89.11 10.35 44 129878 561 34826448
Palmoplantar keratoderma 86.97 10.35 66 129856 1887 34825122
Sepsis 84.32 10.35 326 129596 166235 34660774
Facial pain 83.52 10.35 85 129837 3619 34823390
Pancreatitis acute 81.45 10.35 260 129662 27881 34799128
Toxicity to various agents 81.14 10.35 426 129496 199936 34627073
Pruritus genital 77.84 10.35 65 129857 2139 34824870
Sleep terror 74.98 10.35 65 129857 2253 34824756
Thrombocytopenia 71.48 10.35 318 129604 155929 34671080
Atrial tachycardia 70.36 10.35 77 129845 3568 34823441
Immunisation 70.33 10.35 46 129876 1031 34825978
Blood potassium decreased 69.67 10.35 184 129738 17731 34809278
Tension headache 67.12 10.35 69 129853 2973 34824036
Transient ischaemic attack 64.90 10.35 238 129684 27375 34799634
Anosmia 62.52 10.35 76 129846 3948 34823061
Cytomegalovirus infection 58.02 10.35 13 129909 26122 34800887
Treatment failure 56.57 10.35 54 129868 46643 34780366
Product use issue 54.92 10.35 94 129828 63122 34763887
Pancreatitis 53.11 10.35 285 129637 38606 34788403
Hypertensive crisis 50.60 10.35 105 129817 8646 34818363
IgM nephropathy 50.15 10.35 19 129903 119 34826890
Foetal exposure during pregnancy 49.83 10.35 41 129881 38060 34788949
Cytokine release syndrome 49.55 10.35 12 129910 22865 34804144
Hepatic function abnormal 49.54 10.35 55 129867 44308 34782701
Bundle branch block left 47.30 10.35 82 129840 5897 34821112
Eye pruritus 47.04 10.35 93 129829 7396 34819613
Hypovolaemia 46.76 10.35 105 129817 9129 34817880
Interstitial lung disease 45.68 10.35 110 129812 65172 34761837
Leukopenia 44.71 10.35 105 129817 62751 34764258
Hospitalisation 44.65 10.35 90 129832 56812 34770197
Blood mercury abnormal 43.58 10.35 20 129902 214 34826795
Pain of skin 43.47 10.35 80 129842 6029 34820980
5-hydroxyindolacetic acid in urine increased 41.79 10.35 20 129902 237 34826772
Orthostatic intolerance 41.56 10.35 30 129892 793 34826216
Sprue-like enteropathy 41.25 10.35 25 129897 488 34826521
Myelosuppression 40.01 10.35 11 129911 19254 34807755
Drug intolerance 39.63 10.35 103 129819 59467 34767542
Cardiac failure congestive 38.52 10.35 476 129446 82794 34744215
Lactic acidosis 38.47 10.35 241 129681 34531 34792478
Blood creatinine increased 38.12 10.35 529 129393 94447 34732562
Injury 37.15 10.35 164 129758 20523 34806486
Cardiomegaly 37.06 10.35 134 129788 15304 34811705
Carotid artery stenosis 36.06 10.35 66 129856 4953 34822056
Hypochloraemia 36.01 10.35 25 129897 620 34826389
Interstitial granulomatous dermatitis 35.29 10.35 16 129906 166 34826843
Blood urea increased 35.19 10.35 213 129709 30151 34796858
Drug resistance 35.03 10.35 27 129895 25900 34801109
Tinnitus 35.01 10.35 158 129764 19960 34807049
Metabolic alkalosis 34.86 10.35 35 129887 1466 34825543
Lip swelling 34.79 10.35 135 129787 15945 34811064
Amnesia 34.47 10.35 192 129730 26371 34800638
Renal artery stenosis 33.99 10.35 42 129880 2219 34824790
Blood chloride decreased 33.76 10.35 55 129867 3758 34823251
Muscle twitching 33.37 10.35 99 129823 10199 34816810
Bronchopulmonary aspergillosis 33.13 10.35 7 129915 14652 34812357
Chest pain 32.75 10.35 657 129265 126105 34700904
Pancytopenia 32.74 10.35 213 129709 94944 34732065
Acute myocardial infarction 32.10 10.35 323 129599 53396 34773613
Inappropriate antidiuretic hormone secretion 31.73 10.35 112 129810 12641 34814368
Diplopia 31.37 10.35 135 129787 16708 34810301
Hypomagnesaemia 31.10 10.35 162 129760 21689 34805320
Pulmonary valve disease 30.93 10.35 18 129904 325 34826684
Drug-induced liver injury 30.83 10.35 37 129885 28795 34798214
Bone marrow failure 30.80 10.35 38 129884 29215 34797794
Liver disorder 30.58 10.35 47 129875 32950 34794059
Vasculitis 30.54 10.35 102 129820 11194 34815815
Neutrophil count decreased 29.85 10.35 94 129828 51010 34775999
Arteriosclerosis coronary artery 29.65 10.35 108 129814 12377 34814632
Glycosylated haemoglobin increased 29.33 10.35 101 129821 11259 34815750
Pneumonia aspiration 29.00 10.35 71 129851 41832 34785177
Renal failure 29.00 10.35 662 129260 129895 34697114
Pericardial disease 28.85 10.35 19 129903 431 34826578
Infection 28.56 10.35 209 129713 90706 34736303
Granulomatous pneumonitis 28.53 10.35 9 129913 29 34826980
Hypertension 28.21 10.35 685 129237 135758 34691251
Hypercalcaemia 28.06 10.35 123 129799 15345 34811664
Platelet count decreased 27.98 10.35 297 129625 119420 34707589
Aspergillus infection 27.39 10.35 6 129916 12248 34814761
Erectile dysfunction 27.33 10.35 150 129772 20487 34806522
Bacteraemia 27.32 10.35 20 129902 19697 34807312
Blood pressure systolic increased 27.23 10.35 162 129760 22790 34804219
Low density lipoprotein decreased 27.18 10.35 27 129895 1116 34825893
Sopor 27.01 10.35 6 129916 12130 34814879
Neurotoxicity 26.65 10.35 17 129905 17993 34809016
Lower respiratory tract infection 26.60 10.35 48 129874 31589 34795420
Intentional self-injury 26.55 10.35 9 129913 13762 34813247
Blood sodium decreased 26.33 10.35 125 129797 16126 34810883
Visual impairment 26.28 10.35 225 129697 35577 34791432
Angina pectoris 25.66 10.35 202 129720 31161 34795848
Blindness 25.55 10.35 117 129805 14869 34812140
Fall 25.55 10.35 958 128964 201927 34625082
Hypertensive emergency 25.54 10.35 25 129897 1015 34825994
Nodular rash 25.53 10.35 11 129911 100 34826909
Actinic keratosis 25.47 10.35 54 129868 4513 34822496
Choroidal effusion 25.38 10.35 13 129909 180 34826829
Rash papular 25.34 10.35 90 129832 10188 34816821
Vertigo 25.20 10.35 172 129750 25364 34801645
Mitral valve incompetence 24.99 10.35 116 129806 14827 34812182
Ventricular tachycardia 24.46 10.35 176 129746 26403 34800606
Disseminated intravascular coagulation 24.40 10.35 27 129895 21789 34805220
Oedema peripheral 24.00 10.35 599 129323 119213 34707796
Peritonitis 23.46 10.35 16 129906 16349 34810660
Hyperhidrosis 23.23 10.35 403 129519 75289 34751720
Blood triglycerides increased 23.01 10.35 109 129813 14050 34812959
C-reactive protein increased 22.98 10.35 113 129809 53985 34773024
Drug dependence 22.92 10.35 34 129888 24183 34802826
Choroidal detachment 22.73 10.35 16 129906 406 34826603
Lichen planus 22.66 10.35 23 129899 976 34826033
Mucosal inflammation 22.58 10.35 71 129851 38551 34788458
Hepatic neoplasm 22.43 10.35 32 129890 1945 34825064
Muscular weakness 22.33 10.35 388 129534 72509 34754500
Bradycardia 22.24 10.35 399 129523 75019 34751990
Angina unstable 22.16 10.35 94 129828 11559 34815450
Lymphocyte count decreased 22.16 10.35 31 129891 22591 34804418
Graft versus host disease 22.01 10.35 6 129916 10563 34816446
Malignant neoplasm progression 21.98 10.35 215 129707 87831 34739178
Renal injury 21.83 10.35 91 129831 11104 34815905
Multiple organ dysfunction syndrome 21.71 10.35 181 129741 76385 34750624
Physical examination abnormal 21.71 10.35 14 129908 306 34826703
Septic shock 21.67 10.35 167 129755 71667 34755342
Polydipsia 21.50 10.35 46 129876 3869 34823140
High density lipoprotein decreased 21.43 10.35 42 129880 3318 34823691
Disease progression 21.43 10.35 278 129644 107799 34719210
Pneumocystis jirovecii pneumonia 21.39 10.35 25 129897 19685 34807324
Swollen tongue 21.28 10.35 109 129813 14496 34812513
Aplastic anaemia 21.23 10.35 5 129917 9711 34817298
Tricuspid valve incompetence 21.16 10.35 82 129840 9678 34817331
Vestibular neuronitis 21.16 10.35 12 129910 206 34826803
Inappropriate schedule of product administration 21.13 10.35 140 129782 62156 34764853
Ascites 21.12 10.35 95 129827 46476 34780533
Congenital diaphragmatic anomaly 21.03 10.35 7 129915 28 34826981
Osteoarthritis 20.94 10.35 140 129782 20502 34806507
Hyperlipidaemia 20.87 10.35 108 129814 14421 34812588
Arrhythmia 20.76 10.35 214 129708 35594 34791415
Therapeutic product effect incomplete 20.65 10.35 107 129815 50434 34776575
Sedation 20.36 10.35 29 129893 20977 34806032
Akathisia 20.22 10.35 3 129919 8106 34818903
Immune reconstitution inflammatory syndrome 20.17 10.35 4 129918 8755 34818254
Heart rate increased 20.17 10.35 262 129660 46081 34780928
Blood cholesterol increased 20.05 10.35 138 129784 20405 34806604
Pseudolymphoma 20.05 10.35 18 129904 654 34826355
Palpitations 19.97 10.35 232 129690 39754 34787255
Pulmonary valve stenosis congenital 19.95 10.35 10 129912 132 34826877
Drug ineffective for unapproved indication 1