mebutizide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 1645 3568-00-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mebutizide
  • mebuthiazide
  • mebutizid
  • Molecular weight: 381.89
  • Formula: C13H20ClN3O4S2
  • CLOGP: 2.54
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -3.07
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.144 Moderate 0.68
caco2-efflux Caco-2 efflux ratio (BA/AB) 25.293 Moderate 0.68
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 7.780 10^-6 cm/s Moderate 0.68
dh-clint Dog hepatocyte intrinsic clearance 3.357 uL/min/10^6 cells Moderate 0.68
dppb Dog plasma protein binding (% unbound) 9.680 % Moderate 0.68
fcs-ppb Fetal calf serum protein binding (% unbound) 24.150 % Moderate 0.68
herg hERG pIC50 4.451 pIC50 Moderate 0.68
hh-clint Human hepatocyte intrinsic clearance 3.516 uL/min/10^6 cells Moderate 0.68
hlm-clint Human liver microsomal intrinsic clearance 29.992 uL/min/mg protein Moderate 0.68
hppb Human plasma protein binding (% unbound) 9.380 % Moderate 0.68
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK10,MAPK14,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC,SYK,TEK,TGFBR1,ZAP70 32
kinase-selectivity-class GRK2,MAP2K6,PDK1,PDK2,TEK 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 9.333 Moderate 0.68
mh-clint Mouse hepatocyte intrinsic clearance 61.802 Moderate 0.68
mppb Mouse plasma protein binding (% unbound) 7.550 Moderate 0.68
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 29.785 Moderate 0.68
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 15.130 % Moderate 0.68
rh-clint Rat hepatocyte intrinsic clearance 31.189 uL/min/10^6 cells Moderate 0.68
rh-fuinc Rat hepatocyte fraction unbound in incubation 59.160 % Moderate 0.68
rppb Rat plasma protein binding (% unbound) 9.540 % Moderate 0.68
solubility-dd Solubility at pH 7.4 in DMSO 217.771 uM Moderate 0.68

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03AA13 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, plain
ATC C03EA05 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Low-ceiling diuretics and potassium-sparing agents
CHEBI has role CHEBI:35554 cardiovascular drug

Related Drugs by ATC class:

C03AA Thiazides, plain 9 drugs
bendroflumethiazidechlorothiazidecyclopenthiazidecyclothiazidehydrochlorothiazidehydroflumethiazidemethylclothiazidepolythiazidetrichlormethiazide
C03EA Low-ceiling diuretics and potassium-sparing agents 9 drugs
altizidebendroflumethiazidebutizidechlortalidonecyclopenthiazideepitizidehydrochlorothiazidemetolazonetrichlormethiazide

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.74 acidic
pKa2 10.46 acidic
pKa3 1.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07172 KEGG_DRUG
C0603520 UMLSCUI
CHEBI:135597 CHEBI
CHEMBL2105212 ChEMBL_ID
DB13430 DRUGBANK_ID
C008338 MESH_SUPPLEMENTAL_RECORD_UI
71652 PUBCHEM_CID
1859 INN_ID
7738AS8324 UNII

Pharmaceutical products:

None