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methylclothiazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diuretics, chlorothiazide derivatives | 1759 | 135-07-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 5 | mg | O |
| 5 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,SYK,TEK,ZAP70 | 30 | |||
| kinase-selectivity-class | GRK2,MAP2K6,PDK1,PDK2,TEK | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 21, 1960 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C03AA08 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, plain |
| ATC | C03AB08 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides and potassium in combination |
| FDA CS | M0471776 | Thiazides |
| FDA PE | N0000175359 | Increased Diuresis |
| FDA EPC | N0000175419 | Thiazide Diuretic |
| MeSH PA | D004232 | Diuretics |
| MeSH PA | D045283 | Natriuretic Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D049993 | Sodium Chloride Symporter Inhibitors |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
Related Drugs by ATC class:
C03AA Thiazides, plain 9 drugs
C03AB Thiazides and potassium in combination 8 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Edema | indication | 267038008 | |
| Renal Disease with Edema | indication | ||
| Pulmonary Edema due to Chronic Heart Failure | indication | ||
| Peripheral Edema due to Chronic Heart Failure | indication | ||
| Diabetes insipidus | off-label use | 15771004 | DOID:9409 |
| Calcium renal calculus | off-label use | 427649000 | |
| Fluid volume disorder | contraindication | 1860003 | |
| Anuria | contraindication | 2472002 | DOID:2983 |
| Suicidal thoughts | contraindication | 6471006 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Chronic disease of respiratory system | contraindication | 17097001 | |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Electroconvulsive therapy | contraindication | 23835007 | |
| Depressive disorder | contraindication | 35489007 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Hypokalemia | contraindication | 43339004 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Chronic heart failure | contraindication | 48447003 | |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Oliguria | contraindication | 83128009 | |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Impaired renal function disorder | contraindication | 197663003 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Calculus in biliary tract | contraindication | 266474003 | |
| Neonatal hyperbilirubinemia | contraindication | 281610001 | |
| Hypertriglyceridemia | contraindication | 302870006 | |
| Azotemia | contraindication | 445009001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.54 | acidic |
| pKa2 | 1.39 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Solute carrier family 12 member 3 | Transporter | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018442 | VUID |
| N0000146766 | NUI |
| D00656 | KEGG_DRUG |
| 4018442 | VANDF |
| CHEMBL1577 | ChEMBL_ID |
| 4121 | PUBCHEM_CID |
| DB00232 | DRUGBANK_ID |
| 224934 | RXNORM |
| 1033 | MMSL |
| 5085 | MMSL |
| 735 | MMSL |
| d00643 | MMSL |
| 002301 | NDDF |
| 387373008 | SNOMEDCT_US |
| 66919007 | SNOMEDCT_US |
| C0025696 | UMLSCUI |
| D008736 | MESH_DESCRIPTOR_UI |
| CHEBI:6847 | CHEBI |
| 7235 | IUPHAR_LIGAND_ID |
| 1050 | INN_ID |
| L3H46UAC61 | UNII |
| L3H46UAC61 | INXIGHT DRUGS |
Pharmaceutical products:
None