Stem definition | Drug id | CAS RN |
---|---|---|
diuretics, chlorothiazide derivatives | 1759 | 135-07-9 |
Dose | Unit | Route |
---|---|---|
5 | mg | O |
5 | mg | O |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 21, 1960 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | C03AA08 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, plain |
ATC | C03AB08 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides and potassium in combination |
FDA CS | M0471776 | Thiazides |
FDA PE | N0000175359 | Increased Diuresis |
FDA EPC | N0000175419 | Thiazide Diuretic |
MeSH PA | D004232 | Diuretics |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D045283 | Natriuretic Agents |
MeSH PA | D049993 | Sodium Chloride Symporter Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Edema | indication | 267038008 | |
Renal Disease with Edema | indication | ||
Pulmonary Edema due to Chronic Heart Failure | indication | ||
Peripheral Edema due to Chronic Heart Failure | indication | ||
Diabetes insipidus | off-label use | 15771004 | DOID:9409 |
Calcium renal calculus | off-label use | 427649000 | |
Fluid volume disorder | contraindication | 1860003 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Suicidal thoughts | contraindication | 6471006 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Hypercholesterolemia | contraindication | 13644009 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Electroconvulsive therapy | contraindication | 23835007 | |
Depressive disorder | contraindication | 35489007 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Oliguria | contraindication | 83128009 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Calculus in biliary tract | contraindication | 266474003 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Azotemia | contraindication | 445009001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.54 | acidic |
pKa2 | 1.39 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 12 member 3 | Transporter | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4018442 | VUID |
N0000146766 | NUI |
D00656 | KEGG_DRUG |
4018442 | VANDF |
CHEBI:6847 | CHEBI |
CHEMBL1577 | ChEMBL_ID |
4121 | PUBCHEM_CID |
7235 | IUPHAR_LIGAND_ID |
DB00232 | DRUGBANK_ID |
224934 | RXNORM |
1033 | MMSL |
5085 | MMSL |
735 | MMSL |
d00643 | MMSL |
002301 | NDDF |
387373008 | SNOMEDCT_US |
66919007 | SNOMEDCT_US |
D008736 | MESH_DESCRIPTOR_UI |
C0025696 | UMLSCUI |
1050 | INN_ID |
L3H46UAC61 | UNII |
None