methylclothiazide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 1759 135-07-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methychlothiazide
  • methylclothiazide
  • methyclothiazide
  • methyclothiazid
  • enduron
A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
  • Molecular weight: 360.22
  • Formula: C9H11Cl2N3O4S2
  • CLOGP: 0.94
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 109.57
  • ALOGS: -2.64
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
5 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 21, 1960 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03AA08 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, plain
ATC C03AB08 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides and potassium in combination
FDA CS M0471776 Thiazides
FDA PE N0000175359 Increased Diuresis
FDA EPC N0000175419 Thiazide Diuretic
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049993 Sodium Chloride Symporter Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Edema indication 267038008
Renal Disease with Edema indication
Pulmonary Edema due to Chronic Heart Failure indication
Peripheral Edema due to Chronic Heart Failure indication
Diabetes insipidus off-label use 15771004 DOID:9409
Calcium renal calculus off-label use 427649000
Fluid volume disorder contraindication 1860003
Anuria contraindication 2472002 DOID:2983
Suicidal thoughts contraindication 6471006
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Chronic disease of respiratory system contraindication 17097001
Cirrhosis of liver contraindication 19943007 DOID:5082
Electroconvulsive therapy contraindication 23835007
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Diabetes mellitus contraindication 73211009 DOID:9351
Oliguria contraindication 83128009
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Calculus in biliary tract contraindication 266474003
Neonatal hyperbilirubinemia contraindication 281610001
Hypertriglyceridemia contraindication 302870006
Azotemia contraindication 445009001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.54 acidic
pKa2 1.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 3 Transporter INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018442 VUID
N0000146766 NUI
D00656 KEGG_DRUG
4018442 VANDF
CHEBI:6847 CHEBI
CHEMBL1577 ChEMBL_ID
4121 PUBCHEM_CID
7235 IUPHAR_LIGAND_ID
1050 INN_ID
L3H46UAC61 UNII
DB00232 DRUGBANK_ID
224934 RXNORM
1033 MMSL
5085 MMSL
735 MMSL
d00643 MMSL
002301 NDDF
387373008 SNOMEDCT_US
66919007 SNOMEDCT_US
D008736 MESH_DESCRIPTOR_UI
C0025696 UMLSCUI

Pharmaceutical products:

None