Stem definition | Drug id | CAS RN |
---|---|---|
diuretics, chlorothiazide derivatives | 2733 | 133-67-5 |
Dose | Unit | Route |
---|---|---|
4 | mg | O |
4 | mg | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.18 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
March 9, 1960 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Vital capacity decreased | 226.99 | 33.26 | 40 | 2190 | 1248 | 56288589 |
Reversible airways obstruction | 224.11 | 33.26 | 40 | 2190 | 1344 | 56288493 |
Sputum culture positive | 214.99 | 33.26 | 40 | 2190 | 1699 | 56288138 |
Bronchial secretion retention | 212.14 | 33.26 | 40 | 2190 | 1828 | 56288009 |
Eosinophil count increased | 151.49 | 33.26 | 41 | 2189 | 9596 | 56280241 |
Upper-airway cough syndrome | 147.64 | 33.26 | 40 | 2190 | 9398 | 56280439 |
Multiple allergies | 143.43 | 33.26 | 40 | 2190 | 10456 | 56279381 |
Obstructive airways disorder | 136.11 | 33.26 | 43 | 2187 | 17239 | 56272598 |
Pulmonary mass | 117.10 | 33.26 | 40 | 2190 | 20430 | 56269407 |
Full blood count abnormal | 107.06 | 33.26 | 40 | 2190 | 26422 | 56263415 |
Respiratory tract infection | 95.04 | 33.26 | 40 | 2190 | 36031 | 56253806 |
Renal impairment | 64.57 | 33.26 | 40 | 2190 | 80673 | 56209164 |
Cardiac failure | 63.94 | 33.26 | 40 | 2190 | 82053 | 56207784 |
Sputum culture | 41.60 | 33.26 | 7 | 2223 | 164 | 56289673 |
Pneumonia | 38.10 | 33.26 | 62 | 2168 | 407036 | 55882801 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardiac failure | 82.72 | 26.37 | 56 | 1871 | 85897 | 31609520 |
Renal impairment | 80.11 | 26.37 | 55 | 1872 | 86294 | 31609123 |
Hepatic function abnormal | 54.82 | 26.37 | 33 | 1894 | 41189 | 31654228 |
Shoshin beriberi | 43.75 | 26.37 | 7 | 1920 | 75 | 31695342 |
Cerebral infarction | 40.31 | 26.37 | 23 | 1904 | 25954 | 31669463 |
Interstitial lung disease | 32.31 | 26.37 | 28 | 1899 | 61375 | 31634042 |
Renal ischaemia | 30.57 | 26.37 | 7 | 1920 | 534 | 31694883 |
Vitamin B1 deficiency | 28.49 | 26.37 | 6 | 1921 | 310 | 31695107 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Vital capacity decreased | 193.42 | 25.06 | 38 | 4324 | 1371 | 70922711 |
Reversible airways obstruction | 188.44 | 25.06 | 38 | 4324 | 1569 | 70922513 |
Bronchial secretion retention | 164.68 | 25.06 | 38 | 4324 | 2972 | 70921110 |
Sputum culture positive | 160.59 | 25.06 | 38 | 4324 | 3316 | 70920766 |
Cardiac failure | 140.41 | 25.06 | 95 | 4267 | 143446 | 70780636 |
Renal impairment | 133.04 | 25.06 | 92 | 4270 | 143845 | 70780237 |
Multiple allergies | 128.98 | 25.06 | 38 | 4324 | 7722 | 70916360 |
Upper-airway cough syndrome | 124.67 | 25.06 | 39 | 4323 | 9692 | 70914390 |
Eosinophil count increased | 115.08 | 25.06 | 41 | 4321 | 15181 | 70908901 |
Obstructive airways disorder | 96.88 | 25.06 | 42 | 4320 | 26071 | 70898011 |
Pulmonary mass | 90.50 | 25.06 | 40 | 4322 | 25993 | 70898089 |
Respiratory tract infection | 77.52 | 25.06 | 42 | 4320 | 42356 | 70881726 |
Full blood count abnormal | 74.57 | 25.06 | 38 | 4324 | 33840 | 70890242 |
Hepatic function abnormal | 71.11 | 25.06 | 47 | 4315 | 67949 | 70856133 |
Cerebral infarction | 55.58 | 25.06 | 34 | 4328 | 42975 | 70881107 |
Shoshin beriberi | 43.66 | 25.06 | 7 | 4355 | 75 | 70924007 |
Interstitial lung disease | 39.63 | 25.06 | 40 | 4322 | 104645 | 70819437 |
Hyperuricaemia | 38.57 | 25.06 | 17 | 4345 | 10949 | 70913133 |
Right ventricular failure | 32.37 | 25.06 | 19 | 4343 | 22255 | 70901827 |
Fatigue | 32.12 | 25.06 | 6 | 4356 | 824313 | 70099769 |
Pneumonia | 31.54 | 25.06 | 94 | 4268 | 596138 | 70327944 |
Cardiac failure chronic | 30.03 | 25.06 | 14 | 4348 | 10255 | 70913827 |
Decreased appetite | 29.93 | 25.06 | 61 | 4301 | 304719 | 70619363 |
Uraemic encephalopathy | 29.83 | 25.06 | 7 | 4355 | 587 | 70923495 |
Platelet count decreased | 28.24 | 25.06 | 44 | 4318 | 178178 | 70745904 |
Sputum culture | 27.73 | 25.06 | 5 | 4357 | 112 | 70923970 |
Upper respiratory tract inflammation | 27.45 | 25.06 | 10 | 4352 | 3932 | 70920150 |
Renal ischaemia | 25.53 | 25.06 | 7 | 4355 | 1096 | 70922986 |
None
Source | Code | Description |
---|---|---|
ATC | C03AA06 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, plain |
ATC | C03AB06 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides and potassium in combination |
ATC | C03EA02 | CARDIOVASCULAR SYSTEM DIURETICS DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION Low-ceiling diuretics and potassium-sparing agents |
CHEBI has role | CHEBI:35498 | diuretics |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004232 | Diuretics |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D045283 | Natriuretic Agents |
MeSH PA | D049993 | Sodium Chloride Symporter Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Suicidal thoughts | contraindication | 6471006 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic disease of respiratory system | contraindication | 17097001 | |
Electroconvulsive therapy | contraindication | 23835007 | |
Depressive disorder | contraindication | 35489007 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Calculus in biliary tract | contraindication | 266474003 |
Species | Use | Relation |
---|---|---|
Cattle | No Use Class Stated Or Implied | Indication |
Product | Applicant | Ingredients |
---|---|---|
Naquasone Bolus | Intervet Inc. | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.05 | acidic |
pKa2 | 10.3 | acidic |
pKa3 | 1.29 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 12 member 3 | Transporter | INHIBITOR | A2 | 7 | WOMBAT-PK | CHEMBL | |||
Carbonic anhydrase 1 | Enzyme | Ki | 6.46 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 6.35 | CHEMBL | |||||
Carbonic anhydrase 9 | Enzyme | Ki | 7.06 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 6.51 | CHEMBL | |||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 6.12 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 6.87 | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 8.10 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Ki | 5.61 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 5.46 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Ki | 7.04 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 6.19 | CHEMBL |
ID | Source |
---|---|
4018612 | VUID |
N0000146925 | NUI |
D00658 | KEGG_DRUG |
4018612 | VANDF |
C0040899 | UMLSCUI |
CHEBI:9683 | CHEBI |
CHEMBL1054 | ChEMBL_ID |
DB01021 | DRUGBANK_ID |
D014237 | MESH_DESCRIPTOR_UI |
5560 | PUBCHEM_CID |
7314 | IUPHAR_LIGAND_ID |
1012 | INN_ID |
Q58C92TUN0 | UNII |
10772 | RXNORM |
3169 | MMSL |
5619 | MMSL |
d00646 | MMSL |
002300 | NDDF |
11473005 | SNOMEDCT_US |
409112007 | SNOMEDCT_US |
None