butizide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 446 2043-38-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butizide
  • buthiazide
  • butizid
  • isobutylhydrochlorothiazide
  • thiabutazide
3-isobutyl analog of hydrochlorothiazide; structure
  • Molecular weight: 353.84
  • Formula: C11H16ClN3O4S2
  • CLOGP: 1.61
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -2.85
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03EA14 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Low-ceiling diuretics and potassium-sparing agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D045283 Natriuretic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.89 acidic
pKa2 10.47 acidic
pKa3 1.38 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03189 KEGG_DRUG
19882 RXNORM
C0054257 UMLSCUI
CHEBI:135492 CHEBI
CHEMBL2104197 ChEMBL_ID
DB15861 DRUGBANK_ID
C009732 MESH_SUPPLEMENTAL_RECORD_UI
16274 PUBCHEM_CID
20551000122108 SNOMEDCT_US
1410 INN_ID
W00SSD35VW UNII
004333 NDDF

Pharmaceutical products:

None