butizide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 446 2043-38-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butizide
  • buthiazide
  • butizid
  • isobutylhydrochlorothiazide
  • thiabutazide
3-isobutyl analog of hydrochlorothiazide; structure
  • Molecular weight: 353.84
  • Formula: C11H16ClN3O4S2
  • CLOGP: 1.61
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -2.85
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.258 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 32.810 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.766 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 2.710 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 18.990 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 29.760 % Moderate 0.67
herg hERG pIC50 4.260 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 1.104 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 3.828 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 19.130 % Moderate 0.67
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK14,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 33
kinase-selectivity-class GRK2,MAP2K6,PDK1,PDK2,TEK 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.373 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 34.198 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 17.750 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 7.638 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 25.350 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 8.279 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 84.600 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 17.950 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 620.869 uM Moderate 0.67

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03EA14 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Low-ceiling diuretics and potassium-sparing agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics

Related Drugs by ATC class:

C03EA Low-ceiling diuretics and potassium-sparing agents 9 drugs
altizidebendroflumethiazidechlortalidonecyclopenthiazideepitizidehydrochlorothiazidemebutizidemetolazonetrichlormethiazide

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.89 acidic
pKa2 10.47 acidic
pKa3 1.38 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03189 KEGG_DRUG
19882 RXNORM
C0054257 UMLSCUI
CHEBI:750690 CHEBI
CHEMBL2104197 ChEMBL_ID
DB15861 DRUGBANK_ID
C009732 MESH_SUPPLEMENTAL_RECORD_UI
16274 PUBCHEM_CID
20551000122108 SNOMEDCT_US
1410 INN_ID
W00SSD35VW UNII
004333 NDDF
W00SSD35VW INXIGHT DRUGS

Pharmaceutical products:

None