Polymyxin B 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4246 1405-20-5

Description:

MoleculeDescription

Synonyms:

  • Polymyxin B sulfate
  • aerosporin
  • mastimyxin
  • Polymyxin B
A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.
  • Molecular weight: 2392.97
  • Formula: C111H194N32O26
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 490.66
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 MU O
0.15 g P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
March 26, 1957 FDA MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 859.88 9.15 253 81413 3247 90543534
Maternal exposure during delivery 312.45 9.15 121 81545 3725 90543056
Nasal oedema 262.00 9.15 125 81541 6459 90540322
Anaphylactic reaction 250.87 9.15 350 81316 87174 90459607
Pemphigus 238.37 9.15 14 81652 326850 90219931
Anaphylactic shock 238.18 9.15 210 81456 31407 90515374
Cardiac arrest 238.07 9.15 376 81290 104559 90442222
Hand deformity 224.61 9.15 10 81656 296352 90250429
Toxic anterior segment syndrome 223.46 9.15 82 81584 2168 90544613
Glossodynia 214.27 9.15 21 81645 321758 90225023
Systemic lupus erythematosus 209.10 9.15 37 81629 361859 90184922
Synovitis 208.25 9.15 26 81640 329726 90217055
Respiratory tract infection 197.95 9.15 255 81411 58823 90487958
Contraindicated product administered 193.27 9.15 29 81637 320110 90226671
Anti-cyclic citrullinated peptide antibody positive 182.40 9.15 7 81659 236426 90310355
Pericarditis 171.28 9.15 21 81645 270130 90276651
Kounis syndrome 168.00 9.15 69 81597 2484 90544297
Duodenal ulcer perforation 165.90 9.15 8 81658 221280 90325501
Hepatic enzyme increased 164.11 9.15 60 81606 360676 90186105
Arthropathy 155.03 9.15 68 81598 366174 90180607
Wound 154.61 9.15 41 81625 302939 90243842
Joint swelling 150.76 9.15 139 81527 503161 90043620
Methaemoglobinaemia 149.98 9.15 73 81593 3942 90542839
Infusion site pain 134.65 9.15 124 81542 19614 90527167
Folliculitis 134.25 9.15 14 81652 204339 90342442
Helicobacter infection 131.37 9.15 23 81643 226827 90319954
Hypotension 129.22 9.15 608 81058 324789 90221992
Generalised tonic-clonic seizure 126.97 9.15 157 81509 34746 90512035
Sinusitis 126.84 9.15 628 81038 342460 90204321
Drug intolerance 121.02 9.15 135 81531 447456 90099325
Rheumatoid factor positive 120.21 9.15 9 81657 171641 90375140
Infusion site swelling 117.75 9.15 92 81574 11628 90535153
General physical health deterioration 114.89 9.15 91 81575 355024 90191757
Anaesthetic complication 114.20 9.15 52 81614 2413 90544368
Muscle injury 111.28 9.15 14 81652 176640 90370141
Abdominal discomfort 110.38 9.15 162 81504 477166 90069615
Stress cardiomyopathy 109.24 9.15 93 81573 13262 90533519
Liver injury 108.71 9.15 13 81653 170554 90376227
Insurance issue 107.89 9.15 85 81581 10873 90535908
Rheumatic fever 107.30 9.15 8 81658 153113 90393668
Alopecia 105.01 9.15 178 81488 494893 90051888
Impaired healing 104.69 9.15 40 81626 234159 90312622
Psoriatic arthropathy 102.06 9.15 39 81627 228296 90318485
Pulseless electrical activity 100.48 9.15 75 81591 8857 90537924
Infusion site extravasation 99.30 9.15 79 81587 10249 90536532
Macular degeneration 97.24 9.15 144 81522 37826 90508955
Blister 96.33 9.15 55 81611 254943 90291838
Infusion site erythema 95.42 9.15 87 81579 13583 90533198
Infusion site pruritus 94.96 9.15 65 81601 6700 90540081
Bradycardia 91.88 9.15 221 81445 83626 90463155
Type 2 diabetes mellitus 85.51 9.15 38 81628 203206 90343575
Sleep disorder due to general medical condition, insomnia type 84.03 9.15 9 81657 128685 90418096
Seizure 82.11 9.15 313 81353 152316 90394465
Therapeutic product effect decreased 81.42 9.15 78 81588 277493 90269288
Urinary tract infection 80.61 9.15 511 81155 305121 90241660
Mobility decreased 78.88 9.15 66 81600 250668 90296113
COVID-19 75.53 9.15 327 81339 168516 90378265
Irritable bowel syndrome 75.17 9.15 47 81619 207401 90339380
Illness 74.18 9.15 201 81465 81768 90465013
Infusion site haemorrhage 73.61 9.15 51 81615 5360 90541421
Ill-defined disorder 72.54 9.15 38 81628 184853 90361928
Swollen joint count increased 72.04 9.15 8 81658 111198 90435583
Procedural hypotension 71.76 9.15 33 81633 1567 90545214
Infusion site bruising 71.00 9.15 46 81620 4326 90542455
C-reactive protein abnormal 69.36 9.15 15 81651 127414 90419367
Facet joint syndrome 69.33 9.15 5 81661 98384 90448397
Swelling 69.05 9.15 174 81492 418884 90127897
Musculoskeletal stiffness 67.14 9.15 102 81564 296430 90250351
Pulse absent 66.23 9.15 50 81616 6005 90540776
Lip dry 66.06 9.15 7 81659 100948 90445833
Toxicity to various agents 64.91 9.15 463 81203 287383 90259398
Lower respiratory tract infection 64.01 9.15 79 81587 250580 90296201
Corneal oedema 63.40 9.15 32 81634 1869 90544912
Hypersensitivity 63.02 9.15 205 81461 454472 90092309
Anaesthetic complication neurological 62.64 9.15 24 81642 717 90546064
Rheumatoid arthritis 61.74 9.15 148 81518 362466 90184315
Product dose omission issue 60.53 9.15 460 81206 291227 90255554
Apnoea 60.08 9.15 57 81609 9357 90537424
Incorrect drug administration rate 59.07 9.15 44 81622 5179 90541602
Sulphaemoglobinaemia 58.82 9.15 21 81645 512 90546269
Bursitis 57.96 9.15 23 81643 131631 90415150
Peripheral venous disease 57.07 9.15 5 81661 83916 90462865
Staphylococcal infection 56.67 9.15 131 81535 48308 90498473
Seasonal allergy 55.76 9.15 85 81581 22898 90523883
Systemic toxicity 55.07 9.15 17 81649 259 90546522
Inflammation 54.94 9.15 48 81618 178544 90368237
Blood cholesterol increased 54.76 9.15 64 81602 207948 90338833
Mental status changes 54.67 9.15 123 81543 44556 90502225
Ventricular tachycardia 53.86 9.15 87 81579 24621 90522160
Bronchitis 53.62 9.15 276 81390 152651 90394130
Product adhesion issue 53.03 9.15 41 81625 5101 90541680
Unresponsive to stimuli 52.41 9.15 110 81556 38011 90508770
Gait inability 51.92 9.15 34 81632 146422 90400359
Infusion site urticaria 51.78 9.15 27 81639 1688 90545093
Fear 51.39 9.15 69 81597 16553 90530228
Drug ineffective for unapproved indication 51.13 9.15 154 81512 66490 90480291
Sleep disorder 50.99 9.15 62 81604 197968 90348813
Completed suicide 50.98 9.15 34 81632 145024 90401757
Ventricular fibrillation 50.79 9.15 63 81603 13981 90532800
Neurotoxicity 50.12 9.15 78 81588 21389 90525392
Septic arthritis staphylococcal 49.89 9.15 19 81647 558 90546223
Extradural abscess 49.58 9.15 24 81642 1280 90545501
Status epilepticus 48.92 9.15 72 81594 18802 90527979
Obesity 48.85 9.15 17 81649 105490 90441291
Emotional distress 48.33 9.15 104 81562 36558 90510223
Dermatitis contact 47.59 9.15 60 81606 13535 90533246
Cough 47.08 9.15 524 81142 368438 90178343
Extradural haematoma 47.05 9.15 27 81639 2041 90544740
Upper respiratory tract infection 46.67 9.15 234 81432 128084 90418697
Stomatitis 43.72 9.15 116 81550 274582 90272199
Treatment failure 43.49 9.15 135 81531 303793 90242988
Grip strength decreased 42.71 9.15 15 81651 92561 90454220
Administration site pain 42.56 9.15 21 81645 1168 90545613
Lagophthalmos 42.47 9.15 16 81650 456 90546325
Anterior chamber cell 42.08 9.15 18 81648 718 90546063
Peripheral nerve injury 42.01 9.15 18 81648 721 90546060
Abdominal pain upper 41.36 9.15 157 81509 332517 90214264
Product use issue 40.82 9.15 156 81510 329763 90217018
Infusion site mass 40.47 9.15 25 81641 2164 90544617
Fibromyalgia 40.21 9.15 78 81588 206191 90340590
Arthralgia 39.68 9.15 480 81186 778042 89768739
Adjustment disorder with depressed mood 39.65 9.15 3 81663 56750 90490031
Deep vein thrombosis postoperative 39.21 9.15 8 81658 70801 90475980
Premature delivery 39.09 9.15 99 81567 38663 90508118
Endophthalmitis 39.08 9.15 33 81633 4652 90542129
Confusional state 39.05 9.15 197 81469 386008 90160773
Inappropriate schedule of product administration 39.04 9.15 250 81416 149683 90397098
Condition aggravated 39.01 9.15 346 81320 595199 89951582
Renal injury 38.74 9.15 47 81619 10196 90536585
Prescribed underdose 38.51 9.15 10 81656 75009 90471772
Hypopyon 38.35 9.15 18 81648 896 90545885
Type I hypersensitivity 38.28 9.15 31 81635 4124 90542657
Pulmonary fibrosis 38.04 9.15 25 81641 107478 90439303
Embolia cutis medicamentosa 37.67 9.15 16 81650 627 90546154
Spinal epidural haemorrhage 37.58 9.15 13 81653 288 90546493
Spinal epidural haematoma 37.44 9.15 20 81646 1314 90545467
Ear infection 37.42 9.15 143 81523 69632 90477149
Unevaluable event 36.79 9.15 121 81545 54727 90492054
Musculoskeletal pain 36.75 9.15 61 81605 171190 90375591
Discomfort 36.38 9.15 126 81540 274209 90272572
Bronchospasm 36.05 9.15 66 81600 20643 90526138
Liver disorder 35.62 9.15 34 81632 121235 90425546
Tachycardia 35.14 9.15 253 81413 157420 90389361
Bursitis infective 35.12 9.15 20 81646 1490 90545291
Pneumocephalus 35.07 9.15 12 81654 257 90546524
Osteoarthritis 34.79 9.15 78 81588 195652 90351129
Nail disorder 34.14 9.15 6 81660 59061 90487720
C-reactive protein increased 34.14 9.15 70 81596 181319 90365462
Hypercholesterolaemia 33.67 9.15 25 81641 100867 90445914
Infusion site discharge 33.24 9.15 23 81643 2412 90544369
Anhedonia 33.15 9.15 46 81620 11385 90535396
Infusion site rash 32.83 9.15 23 81643 2460 90544321
Prescribed overdose 32.82 9.15 24 81642 97601 90449180
Respiratory depression 32.81 9.15 54 81612 15521 90531260
Knee arthroplasty 32.75 9.15 17 81649 83165 90463616
Paraplegia 32.59 9.15 26 81640 3386 90543395
Kidney infection 32.44 9.15 72 81594 25844 90520937
Night sweats 32.41 9.15 41 81625 128725 90418056
Wound infection 32.23 9.15 29 81637 106373 90440408
Vascular malformation 32.14 9.15 15 81651 737 90546044
Lung disorder 31.60 9.15 54 81612 149829 90396952
Cauda equina syndrome 31.51 9.15 18 81648 1349 90545432
Joint range of motion decreased 31.31 9.15 46 81620 135597 90411184
Vitritis 31.28 9.15 19 81647 1595 90545186
Blepharospasm 31.26 9.15 6 81660 55439 90491342
Multiple allergies 31.21 9.15 52 81614 15094 90531687
Paranasal cyst 31.08 9.15 15 81651 795 90545986
Hip arthroplasty 30.87 9.15 15 81651 76193 90470588
Stridor 30.55 9.15 29 81637 4764 90542017
Anal skin tags 30.42 9.15 14 81652 666 90546115
Meningitis chemical 30.29 9.15 11 81655 282 90546499
Headache 30.27 9.15 1003 80663 861743 89685038
Infusion site nodule 30.14 9.15 19 81647 1704 90545077
Sinus tachycardia 29.99 9.15 74 81592 28439 90518342
Spinal cord compression 29.95 9.15 29 81637 4882 90541899
Myelosuppression 29.79 9.15 6 81660 53585 90493196
Parophthalmia 29.78 9.15 12 81654 411 90546370
Infusion related reaction 29.58 9.15 237 81429 416543 90130238
Epidural haemorrhage 29.55 9.15 11 81655 303 90546478
Fear of eating 29.53 9.15 12 81654 420 90546361
Drug hypersensitivity 29.23 9.15 583 81083 463026 90083755
Chills 28.95 9.15 211 81455 131770 90415011
Purtscher retinopathy 28.92 9.15 9 81657 141 90546640
Eyelid ptosis 28.79 9.15 38 81628 8968 90537813
Oedema 28.56 9.15 291 81375 200004 90346777
Corneal epithelium defect 28.05 9.15 12 81654 479 90546302
Peripheral swelling 27.91 9.15 238 81428 412868 90133913
Pneumonia 27.79 9.15 762 80904 637297 89909484
Ophthalmoplegia 27.42 9.15 18 81648 1731 90545050
Administration site swelling 27.41 9.15 17 81649 1482 90545299
Bone erosion 27.34 9.15 7 81659 53014 90493767
Incorrect route of product administration 27.34 9.15 104 81562 50522 90496259
Cardiogenic shock 27.33 9.15 65 81601 24403 90522378
Hypoxia 27.00 9.15 133 81533 72266 90474515
Platelet aggregation inhibition 26.88 9.15 9 81657 180 90546601
Dry mouth 26.85 9.15 81 81585 183978 90362803
Aqueous fibrin 26.34 9.15 8 81658 115 90546666
Bundle branch block left 26.34 9.15 34 81632 7851 90538930
Skin infection 26.26 9.15 53 81613 17811 90528970
Localised infection 26.16 9.15 78 81588 33484 90513297
Adverse event 25.96 9.15 41 81625 117377 90429404
Stress 25.85 9.15 143 81523 81252 90465529
Drug-induced liver injury 25.74 9.15 26 81640 90292 90456489
Hepatitis 25.64 9.15 16 81650 70723 90476058
Red blood cell sedimentation rate increased 25.63 9.15 22 81644 82573 90464208
Punctate keratitis 25.38 9.15 13 81653 783 90545998
Medical device site cellulitis 25.30 9.15 9 81657 217 90546564
Loss of personal independence in daily activities 25.21 9.15 53 81613 136052 90410729
Trigeminal palsy 24.93 9.15 7 81659 75 90546706
Hepatic cirrhosis 24.80 9.15 13 81653 63240 90483541
Haemorrhoids 24.67 9.15 66 81600 26636 90520145
Retinal vasculitis 24.50 9.15 16 81650 1525 90545256
Circulatory collapse 24.48 9.15 63 81603 24841 90521940
Gastrointestinal disorder 24.21 9.15 134 81532 256553 90290228
Body tinea 24.08 9.15 18 81648 2130 90544651
Therapy partial responder 24.02 9.15 58 81608 21985 90524796
Otitis media 23.95 9.15 28 81638 5842 90540939
Onychomadesis 23.86 9.15 6 81660 45992 90500789
Back pain 23.85 9.15 410 81256 316765 90230016
Hypoaesthesia oral 23.79 9.15 47 81619 15553 90531228
Bacterial infection 23.77 9.15 60 81606 23384 90523397
Epidural analgesia 23.75 9.15 8 81658 163 90546618
Respiratory failure 23.54 9.15 185 81481 118233 90428548
Procedure aborted 23.53 9.15 8 81658 168 90546613
Lupus vulgaris 23.14 9.15 6 81660 45053 90501728
Paralysis 23.11 9.15 39 81627 11439 90535342
Foetal heart rate abnormal 23.07 9.15 13 81653 949 90545832
Sepsis 22.72 9.15 255 81411 179559 90367222
Ventricular hypokinesia 22.67 9.15 26 81640 5315 90541466
Diplopia 22.63 9.15 67 81599 28647 90518134
Upper airway obstruction 22.22 9.15 13 81653 1019 90545762
Infusion site discomfort 22.12 9.15 16 81650 1800 90544981
Medical device site abscess 22.11 9.15 8 81658 203 90546578
Neuromuscular block prolonged 21.82 9.15 11 81655 641 90546140
Visual acuity reduced 21.77 9.15 58 81608 23352 90523429
Post procedural complication 21.72 9.15 51 81615 18991 90527790
Infusion site warmth 21.67 9.15 17 81649 2161 90544620
Psoriasis 21.56 9.15 65 81601 147689 90399092
Anxiety 21.36 9.15 395 81271 309377 90237404
Gastroenteritis viral 21.29 9.15 68 81598 30287 90516494
Chemical burn 21.17 9.15 10 81656 505 90546276
Nephrolithiasis 21.11 9.15 94 81572 48991 90497790
Weight increased 21.10 9.15 258 81408 417669 90129112
Mastoiditis 21.00 9.15 15 81651 1655 90545126
Product distribution issue 20.96 9.15 21 81645 3684 90543097
Nystagmus 20.83 9.15 29 81637 7198 90539583
Nerve root injury 20.83 9.15 6 81660 71 90546710
Cardio-respiratory arrest 20.77 9.15 112 81554 63028 90483753
Foetal exposure during delivery 20.76 9.15 9 81657 371 90546410
Viral infection 20.68 9.15 83 81583 41331 90505450
Vitamin D increased 20.59 9.15 12 81654 934 90545847
Asthenia 20.46 9.15 348 81318 533403 90013378
Atonic urinary bladder 20.41 9.15 7 81659 151 90546630
Ventricular extrasystoles 20.31 9.15 40 81626 13210 90533571
Airway peak pressure increased 19.94 9.15 9 81657 409 90546372
Spinal anaesthesia 19.90 9.15 6 81660 84 90546697
Autoimmune disorder 19.77 9.15 24 81642 76720 90470061
Hyperthermia malignant 19.48 9.15 13 81653 1285 90545496
Monoplegia 19.28 9.15 20 81646 3654 90543127
Meningitis aseptic 19.26 9.15 27 81639 6746 90540035
Mydriasis 19.12 9.15 42 81624 14970 90531811
Procedural complication 19.09 9.15 25 81641 5853 90540928
Infusion site discolouration 19.03 9.15 12 81654 1077 90545704
Iron binding capacity total decreased 19.01 9.15 9 81657 457 90546324
Nerve block 18.90 9.15 11 81655 854 90545927
Cellulitis 18.88 9.15 144 81522 91193 90455588
Poor venous access 18.79 9.15 49 81617 19478 90527303
Underdose 18.52 9.15 13 81653 54004 90492777
Procedural pain 18.40 9.15 69 81597 33291 90513490
Vocal cord dysfunction 18.34 9.15 11 81655 903 90545878
Retinitis 18.14 9.15 6 81660 38452 90508329
Normal newborn 17.93 9.15 54 81612 23308 90523473
Paraesthesia oral 17.90 9.15 66 81600 31593 90515188
Vasoplegia syndrome 17.88 9.15 17 81649 2797 90543984
Vascular stenosis 17.81 9.15 9 81657 527 90546254
Vaginal abscess 17.71 9.15 9 81657 533 90546248
Pulmonary oedema 17.71 9.15 106 81560 61974 90484807
Nail bed tenderness 17.59 9.15 8 81658 370 90546411
Haemodynamic instability 17.46 9.15 35 81631 11704 90535077
Erythema 17.46 9.15 297 81369 228949 90317832
Heliotrope rash 17.42 9.15 7 81659 238 90546543
Tinnitus 17.39 9.15 81 81585 43021 90503760
Arthritis bacterial 17.31 9.15 27 81639 7418 90539363
Abortion spontaneous 17.26 9.15 14 81652 54042 90492739
Transferrin decreased 17.20 9.15 8 81658 390 90546391
Blood pressure decreased 17.15 9.15 121 81545 74774 90472007
Delayed recovery from anaesthesia 17.13 9.15 11 81655 1019 90545762
Tremor 17.04 9.15 212 81454 152961 90393820
Epilepsy 16.97 9.15 30 81636 82176 90464605
Corneal abrasion 16.96 9.15 12 81654 1304 90545477
Retinal artery occlusion 16.93 9.15 15 81651 2256 90544525
Tenderness 16.89 9.15 58 81608 26810 90519971
Multiple organ dysfunction syndrome 16.59 9.15 112 81554 68224 90478557
Left ventricle outflow tract obstruction 16.57 9.15 8 81658 424 90546357
Infection susceptibility increased 16.48 9.15 19 81647 3907 90542874
Anaphylactoid shock 16.47 9.15 8 81658 430 90546351
Eye infarction 16.39 9.15 5 81661 73 90546708
Retinal detachment 16.22 9.15 25 81641 6797 90539984
Inhibitory drug interaction 16.21 9.15 17 81649 3146 90543635
Spinal synovial cyst 16.21 9.15 5 81661 76 90546705
Electrocardiogram ST segment elevation 16.13 9.15 19 81647 3997 90542784
Tachypnoea 16.11 9.15 49 81617 21260 90525521
Cystitis 15.99 9.15 109 81557 66609 90480172
Intercepted medication error 15.96 9.15 10 81656 887 90545894
Inadequate analgesia 15.94 9.15 17 81649 3207 90543574
Infusion site oedema 15.76 9.15 11 81655 1170 90545611
Chest pain 15.69 9.15 388 81278 319257 90227524
Poikiloderma 15.66 9.15 7 81659 311 90546470
Blood pressure abnormal 15.64 9.15 46 81620 19599 90527182
Apgar score low 15.57 9.15 11 81655 1192 90545589
Skin discolouration 15.53 9.15 80 81586 44235 90502546
Memory impairment 15.47 9.15 109 81557 197135 90349646
Quadriparesis 15.45 9.15 15 81651 2534 90544247
Acute respiratory failure 15.40 9.15 78 81588 42840 90503941
Administration site extravasation 15.35 9.15 11 81655 1219 90545562
Nasal mucosal disorder 15.33 9.15 13 81653 1844 90544937
Brain stem syndrome 15.27 9.15 9 81657 715 90546066
Conjunctival oedema 15.26 9.15 10 81656 959 90545822
Anal sphincter atony 15.15 9.15 7 81659 336 90546445
Apnoeic attack 15.15 9.15 7 81659 336 90546445
Allergy to immunoglobulin therapy 15.13 9.15 6 81660 197 90546584
Anorectal discomfort 15.00 9.15 16 81650 3018 90543763
Back injury 14.98 9.15 12 81654 46610 90500171
Coeliac disease 14.95 9.15 11 81655 44599 90502182
Intentional self-injury 14.88 9.15 4 81662 29330 90517451
Streptococcal infection 14.88 9.15 25 81641 7308 90539473
Limb injury 14.82 9.15 62 81604 31446 90515335
Sinusitis bacterial 14.82 9.15 13 81653 1930 90544851
Eyelid contusion 14.79 9.15 5 81661 103 90546678
Thrombocytopenia 14.64 9.15 119 81547 208606 90338175
C-reactive protein 14.61 9.15 5 81661 31362 90515419
Anaphylactoid reaction 14.51 9.15 19 81647 4449 90542332
Peripheral vascular disorder 14.50 9.15 23 81643 6408 90540373
Cancer pain 14.46 9.15 18 81648 4007 90542774
Influenza like illness 14.44 9.15 123 81543 80488 90466293
Orbital infection 14.40 9.15 5 81661 112 90546669
Asthma 14.39 9.15 302 81364 241858 90304923
Incontinence 14.27 9.15 35 81631 13400 90533381
Infusion site streaking 14.26 9.15 8 81658 579 90546202
Proctalgia 14.11 9.15 26 81640 8172 90538609
Sensory loss 14.08 9.15 42 81624 18033 90528748
Wrong product administered 14.07 9.15 25 81641 7640 90539141
Infusion site scar 14.02 9.15 8 81658 598 90546183
Akinesia 14.01 9.15 12 81654 1724 90545057
Body dysmorphic disorder 13.95 9.15 7 81659 404 90546377
Autonomic neuropathy 13.90 9.15 11 81655 1416 90545365
Procedural anxiety 13.88 9.15 9 81657 847 90545934
Product use in unapproved indication 13.88 9.15 399 81267 335837 90210944
Neonatal toxicity 13.84 9.15 4 81662 48 90546733
Axillary nerve injury 13.76 9.15 4 81662 49 90546732
Drug reaction with eosinophilia and systemic symptoms 13.75 9.15 11 81655 42747 90504034
Vision blurred 13.74 9.15 156 81510 110137 90436644
Implant site bruising 13.71 9.15 7 81659 419 90546362
Drug interaction 13.69 9.15 336 81330 276117 90270664
Anterior chamber fibrin 13.67 9.15 5 81661 131 90546650
Nail bed inflammation 13.63 9.15 12 81654 1789 90544992
Nausea 13.63 9.15 1169 80497 1109147 89437634
Pupillary reflex impaired 13.62 9.15 14 81652 2531 90544250
Diplegia 13.58 9.15 11 81655 1464 90545317
Electrocardiogram QRS complex prolonged 13.53 9.15 24 81642 7324 90539457
Influenza 13.51 9.15 188 81478 139076 90407705
Loss of consciousness 13.47 9.15 189 81477 140049 90406732
Lower limb fracture 13.43 9.15 36 81630 84977 90461804
Vascular resistance systemic decreased 13.42 9.15 5 81661 138 90546643
Administration site erythema 13.39 9.15 9 81657 900 90545881
Heparin-induced thrombocytopenia 13.39 9.15 20 81646 5292 90541489
Arthritis 13.35 9.15 92 81574 167223 90379558
Glucose tolerance impaired 13.33 9.15 25 81641 7960 90538821
Gastric mucosa erythema 13.29 9.15 7 81659 447 90546334
Hepatotoxicity 13.28 9.15 13 81653 45829 90500952
Obstruction 13.24 9.15 17 81649 3904 90542877
Sciatica 13.13 9.15 47 81619 101335 90445446
Taste disorder 13.13 9.15 22 81644 61524 90485257
Disseminated intravascular coagulation 13.11 9.15 46 81620 21492 90525289
Tooth infection 13.08 9.15 44 81622 20126 90526655
Spinal stroke 12.95 9.15 4 81662 61 90546720
Calcinosis 12.95 9.15 14 81652 2681 90544100
Rash 12.95 9.15 586 81080 795514 89751267
Cholestasis of pregnancy 12.93 9.15 11 81655 1566 90545215
Agitation 12.88 9.15 104 81562 66994 90479787
Immunodeficiency 12.83 9.15 12 81654 43222 90503559
Respiratory distress 12.75 9.15 69 81597 38877 90507904
Eclampsia 12.68 9.15 7 81659 491 90546290
Sinus disorder 12.64 9.15 63 81603 34384 90512397
Arthritis fungal 12.61 9.15 4 81662 67 90546714
Neuralgia 12.56 9.15 59 81607 31441 90515340
Pneumonia mycoplasmal 12.44 9.15 9 81657 1013 90545768
Metapneumovirus infection 12.38 9.15 10 81656 1325 90545456
Economic problem 12.32 9.15 15 81651 3266 90543515
Varicose vein 12.31 9.15 23 81643 7304 90539477
Hypoaesthesia 12.30 9.15 204 81462 314006 90232775
Allergy to metals 12.30 9.15 9 81657 1031 90545750
Intraocular pressure fluctuation 12.29 9.15 4 81662 73 90546708
Product preparation error 12.27 9.15 28 81638 10233 90536548
Infusion site irritation 12.26 9.15 10 81656 1343 90545438
Brain oedema 12.24 9.15 39 81627 17346 90529435
Trigemino-cardiac reflex 12.19 9.15 4 81662 75 90546706
Retinal haemorrhage 12.16 9.15 20 81646 5744 90541037
Papule 12.07 9.15 24 81642 7978 90538803
Genital ulceration 12.05 9.15 9 81657 1064 90545717
Fear-related avoidance of activities 12.02 9.15 5 81661 186 90546595
Phrenic nerve paralysis 11.99 9.15 6 81660 344 90546437
Liver function test abnormal 11.97 9.15 17 81649 50828 90495953
Orthostatic hypotension 11.96 9.15 12 81654 41815 90504966
Haemangioma congenital 11.96 9.15 7 81659 549 90546232
Liver function test increased 11.90 9.15 38 81628 84817 90461964
Cataract nuclear 11.89 9.15 9 81657 1085 90545696
Tryptase increased 11.83 9.15 7 81659 560 90546221
Depression 11.82 9.15 195 81471 300406 90246375
Spinal cord injury 11.78 9.15 9 81657 1100 90545681
Implant site swelling 11.78 9.15 7 81659 565 90546216
Neuromuscular blockade 11.74 9.15 6 81660 360 90546421
Macular oedema 11.69 9.15 18 81648 4891 90541890
Injection site abscess 11.64 9.15 10 81656 1444 90545337
Myocardial ischaemia 11.62 9.15 33 81633 13781 90533000
Accelerated idioventricular rhythm 11.59 9.15 4 81662 88 90546693
Injection site atrophy 11.59 9.15 8 81658 836 90545945
Gastrooesophageal reflux disease 11.59 9.15 95 81571 166242 90380539
Leukopenia 11.56 9.15 49 81617 100661 90446120
Onychomycosis 11.54 9.15 10 81656 37366 90509415
Tooth disorder 11.51 9.15 57 81609 31033 90515748
Labelled drug-drug interaction medication error 11.47 9.15 34 81632 14548 90532233
Quadriplegia 11.45 9.15 12 81654 2219 90544562
Haematocrit increased 11.44 9.15 14 81652 3064 90543717
Repetitive strain injury 11.40 9.15 5 81661 212 90546569
Mean arterial pressure decreased 11.38 9.15 5 81661 213 90546568
Road traffic accident 11.37 9.15 54 81612 107572 90439209
Cyanosis 11.37 9.15 41 81625 19414 90527367
Product contamination 11.26 9.15 9 81657 1175 90545606
Retinal cyst 11.22 9.15 4 81662 97 90546684
Encephalopathy 11.20 9.15 76 81590 46368 90500413
Renal failure 11.19 9.15 173 81493 130834 90415947
Application site alopecia 11.16 9.15 3 81663 27 90546754
Drug level increased 11.07 9.15 52 81614 27710 90519071
Productive cough 10.99 9.15 112 81554 76951 90469830
Haemorrhagic vasculitis 10.93 9.15 4 81662 105 90546676
Post procedural infection 10.87 9.15 28 81638 11046 90535735
Infusion related hypersensitivity reaction 10.83 9.15 7 81659 655 90546126
Carbon dioxide decreased 10.81 9.15 13 81653 2795 90543986
Central pain syndrome 10.76 9.15 7 81659 663 90546118
Hallucination, tactile 10.67 9.15 6 81660 436 90546345
Drug tolerance decreased 10.67 9.15 8 81658 32122 90514659
Product administration interrupted 10.67 9.15 30 81636 12462 90534319
Sympathectomy 10.61 9.15 3 81663 33 90546748
Coccygectomy 10.61 9.15 3 81663 33 90546748
Cerebral congestion 10.58 9.15 4 81662 115 90546666
Anorgasmia 10.48 9.15 7 81659 693 90546088
Vasospasm 10.45 9.15 8 81658 981 90545800
Suicide attempt 10.41 9.15 34 81632 75365 90471416
Pain 10.39 9.15 1037 80629 995304 89551477
Hordeolum 10.39 9.15 17 81649 4861 90541920
Cardiotoxicity 10.37 9.15 28 81638 11361 90535420
Myelitis 10.35 9.15 11 81655 2067 90544714
Meningoencephalitis bacterial 10.34 9.15 5 81661 266 90546515
Pharyngitis streptococcal 10.30 9.15 30 81636 12712 90534069
Moraxella infection 10.28 9.15 6 81660 468 90546313
Muscle tightness 10.25 9.15 31 81635 13408 90533373
White blood cell disorder 10.25 9.15 13 81653 2951 90543830
Disease progression 10.21 9.15 91 81575 156524 90390257
Foetal death 10.19 9.15 3 81663 20720 90526061
Incision site rash 10.16 9.15 3 81663 39 90546742
Pupil fixed 10.13 9.15 11 81655 2117 90544664
Conduction disorder 10.12 9.15 10 81656 1725 90545056
Incision site swelling 10.12 9.15 5 81661 279 90546502
Product contamination microbial 10.09 9.15 5 81661 281 90546500
Spinal osteoarthritis 10.06 9.15 39 81627 19109 90527672
Speech disorder 10.06 9.15 73 81593 45512 90501269
Eye infection 10.06 9.15 32 81634 14222 90532559
Lymphatic disorder 10.04 9.15 6 81660 489 90546292
Meningitis 9.99 9.15 23 81643 8458 90538323
Respiratory paralysis 9.95 9.15 3 81663 42 90546739
Lupus-like syndrome 9.93 9.15 18 81648 48828 90497953
Body temperature abnormal 9.89 9.15 12 81654 2603 90544178
Concussion 9.83 9.15 27 81639 11064 90535717
Spondylolisthesis 9.78 9.15 15 81651 4060 90542721
Streptococcal sepsis 9.76 9.15 14 81652 3570 90543211
Cardiac dysfunction 9.73 9.15 14 81652 3583 90543198
Device infusion issue 9.72 9.15 12 81654 2650 90544131
Poor quality sleep 9.66 9.15 46 81620 24647 90522134
Inability to afford medication 9.65 9.15 14 81652 3608 90543173
Laryngeal oedema 9.62 9.15 20 81646 6861 90539920
Candida infection 9.61 9.15 58 81608 33999 90512782
Lethargy 9.60 9.15 93 81573 63046 90483735
Neurogenic shock 9.60 9.15 6 81660 530 90546251
Anaesthetic complication cardiac 9.58 9.15 3 81663 48 90546733
Allergic cough 9.52 9.15 8 81658 1120 90545661
Immune thrombocytopenia 9.48 9.15 30 81636 13296 90533485
Supraventricular extrasystoles 9.46 9.15 17 81649 5240 90541541
Retrograde amnesia 9.42 9.15 6 81660 548 90546233
Oropharyngeal pain 9.41 9.15 151 81515 115036 90431745
Ischaemia 9.37 9.15 17 81649 5278 90541503
Femoral nerve injury 9.36 9.15 3 81663 52 90546729
Myelitis transverse 9.31 9.15 9 81657 1511 90545270
Parainfluenzae virus infection 9.23 9.15 12 81654 2791 90543990
Fanconi syndrome 9.18 9.15 10 81656 1933 90544848

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 516.48 10.77 163 47399 2137 42571636
Anaphylactic shock 238.87 10.77 203 47359 23314 42550459
Anaphylactic reaction 218.95 10.77 254 47308 42489 42531284
Methaemoglobinaemia 194.59 10.77 105 47457 5669 42568104
Inspiratory capacity decreased 171.81 10.77 78 47484 2889 42570884
Cardiac arrest 141.43 10.77 350 47212 108970 42464803
Anaesthetic complication 122.95 10.77 50 47512 1407 42572366
Toxic anterior segment syndrome 103.97 10.77 44 47518 1372 42572401
Hypotension 103.68 10.77 563 46999 257068 42316705
Toxicity to various agents 97.80 10.77 509 47053 228627 42345146
Injury 95.28 10.77 121 47441 22195 42551578
Fear 92.04 10.77 85 47477 10880 42562893
Ventricular tachycardia 91.91 10.77 139 47423 30021 42543752
Drug ineffective 89.41 10.77 1083 46479 629114 41944659
Ventricular fibrillation 82.27 10.77 132 47430 29991 42543782
Renal injury 82.06 10.77 84 47478 12196 42561577
Bradycardia 81.73 10.77 245 47317 85239 42488534
Anhedonia 77.64 10.77 66 47496 7574 42566199
Generalised tonic-clonic seizure 76.75 10.77 119 47443 26260 42547513
Emotional distress 76.32 10.77 92 47470 16001 42557772
Drug ineffective for unapproved indication 66.27 10.77 154 47408 46009 42527764
Unresponsive to stimuli 60.38 10.77 118 47444 31285 42542488
Sinusitis 57.49 10.77 148 47414 47144 42526629
Electrocardiogram ST segment elevation 55.68 10.77 49 47513 5890 42567883
Tachycardia 50.44 10.77 235 47327 100852 42472921
Stress 47.31 10.77 132 47430 44080 42529693
Anal inflammation 47.19 10.77 30 47532 2199 42571574
Infusion site extravasation 46.99 10.77 43 47519 5438 42568335
Unevaluable event 44.48 10.77 110 47452 34178 42539595
Hyperthermia malignant 42.39 10.77 30 47532 2628 42571145
Infusion site pain 41.78 10.77 40 47522 5355 42568418
Adulterated product 40.78 10.77 19 47543 747 42573026
Insurance issue 40.68 10.77 35 47527 4081 42569692
Incorrect route of product administration 40.40 10.77 86 47476 24219 42549554
Pain 38.94 10.77 431 47131 244417 42329356
Overdose 38.18 10.77 224 47338 105040 42468733
SARS-CoV-2 test negative 37.86 10.77 24 47538 1751 42572022
Cardiogenic shock 37.73 10.77 106 47456 35534 42538239
Hypoxia 37.60 10.77 166 47396 69620 42504153
Respiratory paralysis 37.45 10.77 11 47551 111 42573662
Accident 37.27 10.77 41 47521 6462 42567311
Neurotoxicity 36.26 10.77 81 47481 23570 42550203
Trigemino-cardiac reflex 35.71 10.77 14 47548 357 42573416
Interstitial lung disease 35.22 10.77 22 47540 78440 42495333
Ear infection 34.80 10.77 56 47506 12748 42561025
Status epilepticus 34.24 10.77 62 47500 15516 42558257
Electrocardiogram QRS complex prolonged 33.87 10.77 37 47525 5786 42567987
Spinal cord infarction 33.86 10.77 16 47546 650 42573123
Infusion site erythema 32.20 10.77 29 47533 3593 42570180
Sinus tachycardia 31.96 10.77 71 47491 20582 42553191
Mydriasis 31.94 10.77 44 47518 8726 42565047
Haemodynamic instability 31.54 10.77 53 47509 12504 42561269
Cauda equina syndrome 30.74 10.77 17 47545 963 42572810
Tracheitis 29.81 10.77 17 47545 1022 42572751
Anaesthetic complication neurological 29.40 10.77 15 47547 721 42573052
Diarrhoea 29.10 10.77 352 47210 460497 42113276
Oculocardiac reflex 28.64 10.77 9 47553 116 42573657
Seizure 28.51 10.77 231 47331 120330 42453443
Apnoea 28.19 10.77 39 47523 7764 42566009
Proctalgia 27.98 10.77 37 47525 7056 42566717
Respiratory tract infection bacterial 26.92 10.77 20 47542 1889 42571884
Multiple organ dysfunction syndrome 26.90 10.77 193 47369 96842 42476931
Bronchospasm 26.71 10.77 50 47512 12835 42560938
Neuromuscular blockade 26.08 10.77 11 47551 340 42573433
Negative pressure pulmonary oedema 25.73 10.77 13 47549 612 42573161
Psoriasis 25.71 10.77 11 47551 48593 42525180
Blood phosphorus increased 25.21 10.77 48 47514 12477 42561296
Respiratory depression 24.96 10.77 61 47501 18807 42554966
Kounis syndrome 24.26 10.77 24 47538 3344 42570429
Decreased appetite 24.19 10.77 122 47440 193015 42380758
Respiratory arrest 23.93 10.77 78 47484 28346 42545427
Agranulocytosis 23.87 10.77 3 47559 30609 42543164
Respiratory tract infection 23.77 10.77 74 47488 26248 42547525
Weight decreased 23.48 10.77 136 47426 207812 42365961
Febrile neutropenia 23.42 10.77 313 47249 185390 42388383
Accidental overdose 23.18 10.77 77 47485 28253 42545520
Vasoplegia syndrome 23.09 10.77 21 47541 2634 42571139
Brain oedema 22.90 10.77 54 47508 16273 42557500
Hyperphosphataemia 22.76 10.77 47 47515 12957 42560816
Chemical burn 22.74 10.77 10 47552 343 42573430
Disease progression 22.74 10.77 83 47479 143573 42430200
Mental status changes 22.54 10.77 100 47462 42015 42531758
Retinal artery occlusion 22.23 10.77 19 47543 2196 42571577
Brain stem syndrome 21.94 10.77 12 47550 665 42573108
Product adhesion issue 21.84 10.77 17 47545 1722 42572051
Rheumatoid arthritis 21.82 10.77 10 47552 42430 42531343
Appendicolith 21.66 10.77 47 47515 13409 42560364
Corneal oedema 21.35 10.77 16 47546 1532 42572241
Neuralgia 21.25 10.77 70 47492 25577 42548196
Infusion site swelling 21.05 10.77 22 47540 3270 42570503
General physical health deterioration 21.02 10.77 92 47470 151154 42422619
Circulatory collapse 20.93 10.77 66 47496 23570 42550203
Prostate cancer 20.75 10.77 12 47550 44631 42529142
Diabetes insipidus 20.57 10.77 23 47539 3690 42570083
Type I hypersensitivity 20.56 10.77 18 47544 2148 42571625
Paraesthesia oral 20.47 10.77 27 47535 5136 42568637
Postoperative delirium 20.46 10.77 11 47551 589 42573184
Endophthalmitis 20.45 10.77 25 47537 4408 42569365
Respiratory tract infection viral 20.43 10.77 22 47540 3384 42570389
Intracranial hypotension 20.40 10.77 10 47552 441 42573332
Drug therapy 20.28 10.77 30 47532 6350 42567423
Myasthenia gravis 20.11 10.77 51 47511 16086 42557687
Myocardial infarction 20.05 10.77 71 47491 123938 42449835
Analgesic therapy 19.77 10.77 30 47532 6494 42567279
Lagophthalmos 19.72 10.77 7 47555 134 42573639
Embolia cutis medicamentosa 19.53 10.77 9 47553 345 42573428
Iron deficiency 19.38 10.77 40 47522 11021 42562752
Acute kidney injury 19.02 10.77 292 47270 367045 42206728
Aqueous fibrin 18.98 10.77 6 47556 79 42573694
Seizure like phenomena 18.94 10.77 13 47549 1084 42572689
Tubulointerstitial nephritis 18.60 10.77 6 47556 31542 42542231
Sleep disorder therapy 18.52 10.77 30 47532 6864 42566909
Enterobacter pneumonia 18.34 10.77 10 47552 551 42573222
Myoclonus 18.30 10.77 51 47511 17014 42556759
Suicide attempt 17.97 10.77 15 47547 46085 42527688
Reperfusion arrhythmia 17.85 10.77 6 47556 97 42573676
Macular ischaemia 17.69 10.77 7 47555 183 42573590
Myalgia 17.62 10.77 52 47510 96028 42477745
Anxiety 17.57 10.77 206 47356 118354 42455419
Spinal meningeal cyst 17.51 10.77 6 47556 103 42573670
Ventricular extrasystoles 17.40 10.77 43 47519 13347 42560426
Loss of consciousness 17.20 10.77 168 47394 92186 42481587
Thyrotoxic crisis 17.10 10.77 11 47551 823 42572950
Administration site pain 17.04 10.77 9 47553 465 42573308
Dermatitis contact 17.01 10.77 23 47539 4480 42569293
Tryptase increased 17.00 10.77 8 47554 322 42573451
Cardiotoxicity 16.83 10.77 30 47532 7415 42566358
Abdominal discomfort 16.68 10.77 37 47525 75218 42498555
Blindness 16.66 10.77 51 47511 17927 42555846
Completed suicide 16.42 10.77 54 47508 96411 42477362
Leukopenia 16.36 10.77 37 47525 74709 42499064
Pneumocystis jirovecii pneumonia 16.31 10.77 4 47558 25177 42548596
Hypoaesthesia oral 15.98 10.77 23 47539 4750 42569023
Laryngospasm 15.89 10.77 15 47547 1973 42571800
Hypoxic-ischaemic encephalopathy 15.87 10.77 24 47538 5178 42568595
Infusion site bruising 15.78 10.77 11 47551 941 42572832
Diabetic ketoacidosis 15.61 10.77 3 47559 22364 42551409
Catecholamine crisis 15.53 10.77 5 47557 70 42573703
Hypophosphataemia 15.45 10.77 55 47507 20890 42552883
Behaviour disorder 15.41 10.77 28 47534 7026 42566747
Therapy non-responder 15.28 10.77 107 47455 53252 42520521
Wrong product administered 15.26 10.77 26 47536 6200 42567573
Anal sphincter atony 14.98 10.77 6 47556 162 42573611
Vitreous disorder 14.91 10.77 6 47556 164 42573609
Post procedural complication 14.87 10.77 39 47523 12551 42561222
Weight increased 14.80 10.77 66 47496 107917 42465856
Hyperaesthesia 14.78 10.77 25 47537 5927 42567846
Hepatitis 14.72 10.77 6 47556 27294 42546479
Frequent bowel movements 14.67 10.77 3 47559 21404 42552369
Body temperature increased 14.63 10.77 53 47509 20305 42553468
Ventricular asystole 14.62 10.77 7 47555 293 42573480
Cardiac failure congestive 14.52 10.77 48 47514 85554 42488219
Haematochezia 14.42 10.77 27 47535 58409 42515364
Bacteroides infection 14.29 10.77 16 47546 2571 42571202
Swelling 13.97 10.77 107 47455 54778 42518995
Torsade de pointes 13.81 10.77 30 47532 8564 42565209
Electrocardiogram T wave amplitude increased 13.79 10.77 5 47557 102 42573671
Treatment noncompliance 13.79 10.77 13 47549 37659 42536114
Delayed recovery from anaesthesia 13.76 10.77 11 47551 1158 42572615
Phaeochromocytoma crisis 13.70 10.77 5 47557 104 42573669
Macroglossia 13.69 10.77 8 47554 504 42573269
Pulse absent 13.67 10.77 25 47537 6302 42567471
Myelosuppression 13.63 10.77 15 47547 40446 42533327
Vitreous floaters 13.60 10.77 20 47542 4210 42569563
Asthenia 13.58 10.77 226 47336 280567 42293206
Cholangitis infective 13.56 10.77 7 47555 345 42573428
Melaena 13.46 10.77 14 47548 38732 42535041
Appendicitis 13.43 10.77 52 47510 20561 42553212
Malaise 13.35 10.77 162 47400 211994 42361779
Malignant neoplasm progression 13.26 10.77 69 47493 108331 42465442
Oxygen saturation decreased 13.20 10.77 120 47442 64567 42509206
Myokymia 13.15 10.77 5 47557 117 42573656
Procedural hypotension 13.02 10.77 10 47552 993 42572780
Pancreatitis acute 12.98 10.77 11 47551 33553 42540220
Postictal state 12.87 10.77 10 47552 1010 42572763
Hepatotoxicity 12.83 10.77 6 47556 25161 42548612
Ophthalmoplegia 12.83 10.77 14 47548 2186 42571587
Asthma 12.72 10.77 32 47530 62282 42511491
Haemoglobin decreased 12.71 10.77 91 47471 132380 42441393
Drug hypersensitivity 12.71 10.77 168 47394 99221 42474552
Procedural pain 12.70 10.77 23 47539 5756 42568017
Therapeutic product effect incomplete 12.57 10.77 39 47523 70900 42502873
Shock 12.57 10.77 65 47497 29056 42544717
Ventricular arrhythmia 12.56 10.77 24 47538 6255 42567518
Dyspnoea exertional 12.52 10.77 23 47539 50125 42523648
Encephalomalacia 12.52 10.77 10 47552 1051 42572722
Oesophageal obstruction 12.49 10.77 8 47554 594 42573179
Blood uric acid increased 12.49 10.77 42 47520 15505 42558268
Respiratory acidosis 12.42 10.77 24 47538 6307 42567466
Blood pH decreased 12.33 10.77 14 47548 2284 42571489
Blood pressure systolic increased 12.33 10.77 8 47554 27960 42545813
Loss of personal independence in daily activities 12.30 10.77 23 47539 49793 42523980
Dyspepsia 12.18 10.77 17 47545 41335 42532438
Mean arterial pressure increased 12.17 10.77 4 47558 60 42573713
Fatigue 12.16 10.77 382 47180 435259 42138514
Brain hypoxia 12.08 10.77 8 47554 629 42573144
Drug-induced liver injury 12.02 10.77 15 47547 38258 42535515
Pulseless electrical activity 11.94 10.77 28 47534 8409 42565364
Pancreatic enzymes increased 11.88 10.77 9 47553 876 42572897
Haemorrhoids 11.85 10.77 44 47518 17053 42556720
Retinal vasculitis 11.79 10.77 8 47554 655 42573118
Upper respiratory tract infection 11.74 10.77 84 47478 42089 42531684
Arthritis 11.70 10.77 18 47544 42047 42531726
Total lung capacity decreased 11.65 10.77 17 47545 3553 42570220
Infusion site pruritus 11.64 10.77 10 47552 1163 42572610
Kidney congestion 11.62 10.77 7 47555 466 42573307
Lung opacity 11.29 10.77 22 47540 5815 42567958
Pulmonary fibrosis 11.27 10.77 8 47554 26673 42547100
Anaemia 11.24 10.77 233 47329 280045 42293728
Open globe injury 11.16 10.77 4 47558 79 42573694
Post herpetic neuralgia 11.12 10.77 10 47552 1236 42572537
Myotonic dystrophy 11.07 10.77 5 47557 183 42573590
Disability 11.04 10.77 22 47540 5911 42567862
Illness 11.01 10.77 56 47506 24874 42548899
Anaesthetic complication pulmonary 10.97 10.77 4 47558 83 42573690
Skin hyperpigmentation 10.97 10.77 18 47544 4163 42569610
Sinus bradycardia 10.95 10.77 39 47523 14814 42558959
Product contamination microbial 10.90 10.77 8 47554 742 42573031
Hypopyon 10.83 10.77 7 47555 528 42573245
Chills 10.80 10.77 156 47406 93910 42479863

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 1345.44 9.56 402 105125 5135 110478637
Anaphylactic reaction 509.42 9.56 586 104941 113714 110370058
Anaphylactic shock 498.64 9.56 405 105122 51141 110432631
Cardiac arrest 407.55 9.56 698 104829 196055 110287717
Toxic anterior segment syndrome 321.95 9.56 122 105405 3332 110480440
Maternal exposure during delivery 286.31 9.56 113 105414 3452 110480320
Methaemoglobinaemia 285.11 9.56 150 105377 9018 110474754
Nasal oedema 253.62 9.56 126 105401 6713 110477059
Hypotension 240.42 9.56 1063 104464 522786 109960986
Anaesthetic complication 227.03 9.56 96 105431 3510 110480262
Synovitis 212.86 9.56 12 105515 274080 110209692
Generalised tonic-clonic seizure 190.94 9.56 248 105279 54432 110429340
Toxicity to various agents 179.46 9.56 919 104608 479636 110004136
Hand deformity 174.61 9.56 8 105519 218498 110265274
Bradycardia 172.00 9.56 426 105101 155091 110328681
Kounis syndrome 167.54 9.56 91 105436 5834 110477938
Systemic lupus erythematosus 165.73 9.56 23 105504 254315 110229457
Respiratory tract infection 158.61 9.56 262 105265 71355 110412417
Inspiratory capacity decreased 156.46 9.56 67 105460 2528 110481244
Joint swelling 155.77 9.56 117 105410 442728 110041044
Helicobacter infection 154.61 9.56 4 105523 181873 110301899
Pemphigus 153.36 9.56 14 105513 214556 110269216
Pericarditis 149.60 9.56 17 105510 219097 110264675
Anti-cyclic citrullinated peptide antibody positive 147.60 9.56 6 105521 181978 110301794
Fear 146.02 9.56 143 105384 23050 110460722
Hepatic enzyme increased 142.30 9.56 64 105463 320828 110162944
Duodenal ulcer perforation 140.38 9.56 7 105520 177693 110306079
Ventricular tachycardia 138.75 9.56 203 105324 49806 110433966
Glossodynia 137.94 9.56 23 105504 221981 110261791
Ventricular fibrillation 137.46 9.56 183 105344 41130 110442642
Contraindicated product administered 137.09 9.56 34 105493 248233 110235539
Renal injury 130.35 9.56 122 105405 18591 110465181
Arthropathy 126.45 9.56 58 105469 287464 110196308
Drug ineffective for unapproved indication 123.63 9.56 291 105236 102547 110381225
Seizure 121.70 9.56 475 105052 220710 110263062
Unresponsive to stimuli 121.10 9.56 218 105309 63572 110420200
Emotional distress 118.60 9.56 178 105349 44669 110439103
General physical health deterioration 118.23 9.56 139 105388 425156 110058616
Anhedonia 110.19 9.56 102 105425 15326 110468446
Folliculitis 107.24 9.56 16 105511 167637 110316135
Stress cardiomyopathy 106.18 9.56 101 105426 15705 110468067
Anaesthetic complication neurological 105.43 9.56 39 105488 994 110482778
Pulseless electrical activity 103.03 9.56 102 105425 16655 110467117
Mobility decreased 101.15 9.56 50 105477 237372 110246400
Abdominal discomfort 100.85 9.56 137 105390 393721 110090051
Unevaluable event 99.41 9.56 192 105335 59035 110424737
Wound 98.93 9.56 50 105477 234387 110249385
Type 2 diabetes mellitus 98.36 9.56 24 105503 177208 110306564
Muscle injury 95.91 9.56 11 105516 140796 110342976
Rheumatoid factor positive 95.65 9.56 8 105519 131632 110352140
Psoriatic arthropathy 94.07 9.56 35 105492 196726 110287046
Rheumatic fever 90.31 9.56 7 105520 122572 110361200
Status epilepticus 90.25 9.56 130 105397 31441 110452331
Tachycardia 84.09 9.56 433 105094 226212 110257560
Rheumatoid arthritis 83.14 9.56 98 105429 299515 110184257
Neurotoxicity 82.36 9.56 146 105381 42061 110441711
Procedural hypotension 80.78 9.56 42 105485 2463 110481309
Liver injury 80.34 9.56 22 105505 150391 110333381
Apnoea 80.14 9.56 81 105446 13558 110470214
Mental status changes 79.38 9.56 204 105323 75918 110407854
Therapeutic product effect decreased 79.04 9.56 70 105457 244246 110239526
Drug ineffective 78.59 9.56 1950 103577 1518590 108965182
Insurance issue 77.42 9.56 71 105456 10541 110473231
Facet joint syndrome 75.87 9.56 4 105523 96824 110386948
C-reactive protein abnormal 75.08 9.56 16 105511 129679 110354093
Corneal oedema 74.13 9.56 43 105484 3130 110480642
Alopecia 73.68 9.56 148 105379 364605 110119167
Drug intolerance 73.03 9.56 176 105351 406336 110077436
Cardiogenic shock 73.01 9.56 166 105361 57172 110426600
Impaired healing 71.66 9.56 50 105477 196667 110287105
Irritable bowel syndrome 70.82 9.56 34 105493 164181 110319591
Sinus tachycardia 68.35 9.56 139 105388 44354 110439418
Product adhesion issue 68.28 9.56 40 105487 2966 110480806
Incorrect route of product administration 68.16 9.56 173 105354 63888 110419884
Pulse absent 68.07 9.56 68 105459 11224 110472548
Bursitis 67.54 9.56 20 105507 129898 110353874
Arthralgia 67.13 9.56 452 105075 779180 109704592
Sleep disorder due to general medical condition, insomnia type 65.48 9.56 11 105516 105632 110378140
Lip dry 65.28 9.56 9 105518 100074 110383698
Bronchospasm 64.75 9.56 109 105418 30130 110453642
Stress 63.48 9.56 233 105294 105115 110378657
Hypercholesterolaemia 62.10 9.56 7 105520 90830 110392942
Inflammation 61.74 9.56 56 105471 193182 110290590
Obesity 61.63 9.56 16 105511 113335 110370437
Cauda equina syndrome 61.13 9.56 33 105494 2089 110481683
Hyperthermia malignant 61.11 9.56 41 105486 3859 110479913
Musculoskeletal stiffness 60.47 9.56 109 105418 279713 110204059
Hypoxia 60.06 9.56 264 105263 129251 110354521
Ill-defined disorder 59.64 9.56 38 105489 156815 110326957
Lagophthalmos 59.43 9.56 22 105505 562 110483210
Completed suicide 59.32 9.56 87 105440 242294 110241478
Peripheral venous disease 58.73 9.56 6 105521 84111 110399661
Endophthalmitis 58.22 9.56 54 105473 8133 110475639
Dermatitis contact 56.21 9.56 68 105459 13885 110469887
Infusion site pain 56.16 9.56 76 105451 17343 110466429
Swollen joint count increased 55.82 9.56 7 105520 83654 110400118
Sulphaemoglobinaemia 55.39 9.56 21 105506 574 110483198
Embolia cutis medicamentosa 55.22 9.56 24 105503 939 110482833
Multiple organ dysfunction syndrome 54.96 9.56 288 105239 151422 110332350
Infusion related reaction 54.48 9.56 184 105343 380978 110102794
Blister 54.30 9.56 83 105444 227293 110256479
Extradural abscess 54.09 9.56 30 105497 2004 110481768
Myelosuppression 53.87 9.56 12 105515 94328 110389444
Haemodynamic instability 53.73 9.56 86 105441 22802 110460970
Osteoarthritis 53.63 9.56 57 105470 182566 110301206
Gait inability 51.90 9.56 33 105494 136343 110347429
Respiratory depression 51.58 9.56 102 105425 31899 110451873
Electrocardiogram ST segment elevation 51.27 9.56 53 105474 9107 110474665
Infusion site bruising 51.18 9.56 36 105491 3658 110480114
Type I hypersensitivity 51.03 9.56 45 105482 6348 110477424
Fibromyalgia 50.57 9.56 53 105474 170856 110312916
Anterior chamber cell 49.77 9.56 24 105503 1197 110482575
Infusion site swelling 49.70 9.56 54 105473 9823 110473949
Abdominal pain upper 49.57 9.56 169 105358 348942 110134830
Hypopyon 48.90 9.56 25 105502 1415 110482357
Trigemino-cardiac reflex 48.87 9.56 18 105509 453 110483319
Premature delivery 47.41 9.56 96 105431 30536 110453236
Extradural haematoma 47.07 9.56 33 105494 3336 110480436
Lower respiratory tract infection 46.25 9.56 102 105425 243004 110240768
Infusion site erythema 46.10 9.56 57 105470 11902 110471870
Anal inflammation 45.87 9.56 29 105498 2467 110481305
Systemic toxicity 45.72 9.56 16 105511 346 110483426
Overdose 45.59 9.56 380 105147 233414 110250358
Electrocardiogram QRS complex prolonged 45.35 9.56 59 105468 12962 110470810
Illness 44.76 9.56 176 105351 81995 110401777
Infusion site extravasation 44.13 9.56 55 105472 11579 110472193
C-reactive protein increased 43.48 9.56 89 105438 217830 110265942
Spinal cord infarction 43.01 9.56 21 105506 1077 110482695
Hypoaesthesia oral 42.85 9.56 66 105461 16936 110466836
Pulmonary fibrosis 42.67 9.56 22 105505 102020 110381752
Retinal artery occlusion 42.36 9.56 34 105493 4215 110479557
Proctalgia 41.58 9.56 57 105470 13165 110470607
Circulatory collapse 41.53 9.56 112 105415 42881 110440891
Infusion site pruritus 41.48 9.56 36 105491 4972 110478800
Respiratory paralysis 41.45 9.56 12 105515 136 110483636
Aqueous fibrin 41.20 9.56 13 105514 201 110483571
Febrile neutropenia 40.76 9.56 472 105055 316295 110167477
Joint range of motion decreased 40.49 9.56 34 105493 121798 110361974
Paraplegia 40.47 9.56 39 105488 6161 110477611
Hepatitis 39.82 9.56 18 105509 90036 110393736
Brain oedema 39.55 9.56 90 105437 31008 110452764
Vitritis 39.44 9.56 27 105500 2626 110481146
Liver disorder 38.92 9.56 47 105480 142196 110341576
Ophthalmoplegia 38.82 9.56 30 105497 3520 110480252
Mydriasis 38.61 9.56 73 105454 22084 110461688
Nail disorder 38.28 9.56 5 105522 57930 110425842
Loss of consciousness 38.23 9.56 319 105208 195987 110287785
Retinal vasculitis 38.14 9.56 24 105503 2025 110481747
Paraesthesia oral 37.99 9.56 93 105434 33578 110450194
Neuromuscular blockade 37.70 9.56 17 105510 727 110483045
Psoriasis 37.53 9.56 47 105480 139946 110343826
Staphylococcal infection 37.44 9.56 149 105378 69795 110413977
Deep vein thrombosis postoperative 37.13 9.56 6 105521 59285 110424487
Grip strength decreased 37.08 9.56 15 105512 80159 110403613
SARS-CoV-2 test negative 37.05 9.56 24 105503 2129 110481643
Haemorrhoids 36.56 9.56 95 105432 35577 110448195
Fear of eating 36.41 9.56 15 105512 513 110483259
Peripheral nerve injury 36.31 9.56 19 105508 1129 110482643
Adulterated product 36.20 9.56 19 105508 1136 110482636
Lung disorder 35.52 9.56 74 105453 179973 110303799
Adverse event 35.38 9.56 31 105496 108778 110374994
Asthenia 35.18 9.56 455 105072 688544 109795228
Vasoplegia syndrome 35.10 9.56 34 105493 5405 110478367
Post procedural complication 34.85 9.56 78 105449 26580 110457192
Urinary tract infection 34.61 9.56 469 105058 325813 110157959
Respiratory tract infection bacterial 34.54 9.56 24 105503 2392 110481380
Paralysis 34.43 9.56 57 105470 15543 110468229
Respiratory failure 34.31 9.56 335 105192 214997 110268775
Meningitis chemical 34.23 9.56 13 105514 357 110483415
Interstitial lung disease 34.09 9.56 50 105477 139284 110344488
Accidental overdose 34.08 9.56 118 105409 51716 110432056
Drug-induced liver injury 33.57 9.56 39 105488 120028 110363744
Weight increased 33.24 9.56 249 105278 419395 110064377
Vascular malformation 33.18 9.56 16 105511 798 110482974
Seasonal allergy 33.17 9.56 64 105463 19658 110464114
Gastrointestinal disorder 33.07 9.56 119 105408 241833 110241939
Pulmonary oedema 33.01 9.56 186 105341 100473 110383299
Arthritis 32.96 9.56 69 105458 167517 110316255
Appendicolith 32.69 9.56 53 105474 14202 110469570
Condition aggravated 32.64 9.56 499 105028 734337 109749435
Cardiotoxicity 32.42 9.56 58 105469 16823 110466949
Prescribed underdose 32.15 9.56 11 105516 65163 110418609
Infusion site haemorrhage 32.06 9.56 30 105497 4568 110479204
Anxiety 31.82 9.56 484 105043 344594 110139178
Spinal epidural haemorrhage 31.72 9.56 12 105515 326 110483446
Delayed recovery from anaesthesia 31.65 9.56 22 105505 2193 110481579
Tracheitis 31.64 9.56 20 105507 1701 110482071
Spinal epidural haematoma 31.60 9.56 20 105507 1705 110482067
Paranasal cyst 31.59 9.56 16 105511 888 110482884
Corneal epithelium defect 31.46 9.56 16 105511 896 110482876
Musculoskeletal pain 31.45 9.56 81 105446 182942 110300830
COVID-19 31.44 9.56 365 105162 244695 110239077
Postoperative delirium 31.41 9.56 16 105511 899 110482873
Chemical burn 31.39 9.56 15 105512 733 110483039
Blepharospasm 31.27 9.56 7 105520 54844 110428928
Blood phosphorus increased 31.20 9.56 56 105471 16284 110467488
Tryptase increased 30.95 9.56 16 105511 927 110482845
Sepsis 30.91 9.56 461 105066 326885 110156887
Nystagmus 30.67 9.56 46 105481 11531 110472241
Ventricular extrasystoles 30.44 9.56 67 105460 22574 110461198
Lower limb fracture 30.40 9.56 17 105510 75331 110408441
Swelling 30.38 9.56 203 105324 350838 110132934
Coeliac disease 30.36 9.56 3 105524 43184 110440588
Visual acuity reduced 30.26 9.56 83 105444 32090 110451682
Respiratory arrest 30.25 9.56 123 105404 58176 110425596
Analgesic therapy 30.16 9.56 36 105491 7248 110476524
Drug therapy 30.14 9.56 36 105491 7255 110476517
Stridor 30.08 9.56 35 105492 6860 110476912
Anal sphincter atony 30.07 9.56 13 105514 502 110483270
Punctate keratitis 29.96 9.56 17 105510 1187 110482585
Wrong product administered 29.68 9.56 44 105483 10916 110472856
Oculocardiac reflex 29.62 9.56 9 105518 122 110483650
Sleep disorder therapy 29.43 9.56 36 105491 7435 110476337
Blood cholesterol increased 29.34 9.56 85 105442 184700 110299072
Myasthenia gravis 29.31 9.56 64 105463 21447 110462325
Underdose 29.21 9.56 12 105515 63542 110420230
Hypersensitivity 29.09 9.56 246 105281 403752 110080020
Neuralgia 29.00 9.56 107 105420 48371 110435401
Pain 28.90 9.56 1149 104378 953806 109529966
Peripheral swelling 28.65 9.56 247 105280 403787 110079985
Hyperphosphataemia 28.58 9.56 54 105473 16327 110467445
Diarrhoea 28.54 9.56 849 104678 1138656 109345116
Oedema 28.40 9.56 316 105211 209660 110274112
Night sweats 28.21 9.56 53 105474 133930 110349842
Purtscher retinopathy 28.20 9.56 10 105517 225 110483547
Onychomadesis 27.76 9.56 5 105522 45658 110438114
Loss of personal independence in daily activities 27.66 9.56 64 105463 149956 110333816
Incorrect drug administration rate 27.51 9.56 30 105497 5478 110478294
Wound infection 27.33 9.56 31 105496 96434 110387338
Red blood cell sedimentation rate increased 27.08 9.56 21 105506 78281 110405491
Accident 26.88 9.56 42 105485 10910 110472862
Blood pressure decreased 26.81 9.56 195 105332 114896 110368876
Neuromuscular block prolonged 26.77 9.56 16 105511 1231 110482541
Infusion site mass 26.68 9.56 18 105509 1710 110482062
Diabetes insipidus 26.44 9.56 32 105495 6538 110477234
Upper respiratory tract infection 26.41 9.56 215 105312 131113 110352659
Suicide attempt 26.39 9.56 36 105491 103358 110380414
Negative pressure pulmonary oedema 26.28 9.56 13 105514 686 110483086
Decreased appetite 26.23 9.56 309 105218 475537 110008235
Procedural pain 26.08 9.56 84 105443 35481 110448291
Epidural haemorrhage 26.01 9.56 11 105516 402 110483370
Upper airway obstruction 25.99 9.56 18 105509 1784 110481988
Lupus-like syndrome 25.83 9.56 4 105523 40788 110442984
Sinusitis 25.77 9.56 412 105115 296276 110187496
Platelet aggregation inhibition 25.44 9.56 9 105518 201 110483571
Product use issue 25.13 9.56 184 105343 311511 110172261
Prescribed overdose 24.97 9.56 28 105499 87553 110396219
Therapy partial responder 24.92 9.56 85 105442 36976 110446796
Multiple allergies 24.67 9.56 43 105484 12220 110471552
Medical device site cellulitis 24.61 9.56 9 105518 222 110483550
Procedural complication 24.59 9.56 35 105492 8370 110475402
Bacterial infection 24.58 9.56 98 105429 45938 110437834
Infusion site urticaria 24.55 9.56 15 105512 1201 110482571
Trigeminal palsy 24.54 9.56 7 105520 75 110483697
Respiratory distress 24.42 9.56 130 105397 68744 110415028
Bursitis infective 24.29 9.56 16 105511 1460 110482312
Pneumocephalus 24.04 9.56 11 105516 487 110483285
Foetal heart rate abnormal 23.74 9.56 12 105515 663 110483109
Drug reaction with eosinophilia and systemic symptoms 23.67 9.56 26 105501 82069 110401703
Body tinea 23.41 9.56 18 105509 2097 110481675
Hip arthroplasty 23.38 9.56 12 105515 55801 110427971
Parophthalmia 23.26 9.56 11 105516 525 110483247
Blindness 23.24 9.56 82 105445 36277 110447495
Brain stem syndrome 23.22 9.56 15 105512 1324 110482448
Epidural analgesia 23.21 9.56 8 105519 165 110483607
Septic arthritis staphylococcal 23.17 9.56 13 105514 888 110482884
Otitis media 23.17 9.56 32 105495 7444 110476328
Knee arthroplasty 23.00 9.56 17 105510 64931 110418841
Spinal cord compression 22.91 9.56 32 105495 7520 110476252
Procedure aborted 22.86 9.56 8 105519 173 110483599
Epilepsy 22.57 9.56 38 105489 100171 110383601
Inadequate analgesia 22.53 9.56 26 105501 5051 110478721
Cyanosis 22.50 9.56 71 105456 29670 110454102
Shock 22.42 9.56 106 105421 53482 110430290
Cardio-respiratory arrest 22.41 9.56 188 105339 115648 110368124
Hepatic cirrhosis 22.31 9.56 19 105508 67607 110416165
Hypophosphataemia 22.22 9.56 76 105451 33106 110450666
Eyelid ptosis 22.11 9.56 43 105484 13284 110470488
Medical device site abscess 21.70 9.56 8 105519 202 110483570
Spinal anaesthesia 21.63 9.56 7 105520 118 110483654
Product dose omission issue 21.60 9.56 429 105098 321353 110162419
Rash 21.43 9.56 608 104919 820356 109663416
Hyperaesthesia 21.43 9.56 45 105482 14682 110469090
Airway peak pressure increased 21.33 9.56 11 105516 634 110483138
Mean arterial pressure decreased 21.08 9.56 10 105517 481 110483291
Nerve root injury 20.89 9.56 6 105521 66 110483706
Confusional state 20.86 9.56 318 105209 468362 110015410
Retinitis 20.86 9.56 3 105524 32324 110451448
Product contamination microbial 20.83 9.56 13 105514 1081 110482691
Myoclonus 20.73 9.56 74 105453 32924 110450848
Hepatotoxicity 20.69 9.56 18 105509 63382 110420390
Carbon dioxide decreased 20.64 9.56 24 105503 4700 110479072
Macular ischaemia 20.62 9.56 8 105519 233 110483539
Pupillary reflex impaired 20.29 9.56 22 105505 3993 110479779
Sleep disorder 20.27 9.56 109 105418 198535 110285237
Nasopharyngitis 20.24 9.56 260 105267 394101 110089671
Stomatitis 20.14 9.56 163 105364 270079 110213693
Infusion site discharge 20.12 9.56 16 105511 1957 110481815
Mastoiditis 20.09 9.56 18 105509 2593 110481179
Torsade de pointes 19.97 9.56 57 105470 22543 110461229
Back pain 19.92 9.56 479 105048 370517 110113255
Pneumocystis jirovecii pneumonia 19.75 9.56 8 105519 42727 110441045
Disease progression 19.69 9.56 144 105383 243890 110239882
Drug level increased 19.68 9.56 94 105433 47625 110436147
Atonic urinary bladder 19.68 9.56 7 105520 159 110483613
Agranulocytosis 19.59 9.56 18 105509 61742 110422030
Tubulointerstitial nephritis 19.49 9.56 14 105513 54270 110429502
Foot deformity 19.47 9.56 11 105516 48469 110435303
Skin infection 19.15 9.56 56 105471 22453 110461319
Cholestasis 19.09 9.56 20 105507 64498 110419274
Miosis 19.00 9.56 55 105472 21928 110461844
Chills 19.00 9.56 271 105256 190309 110293463
Tachypnoea 18.78 9.56 81 105446 39314 110444458
Gastroenteritis viral 18.74 9.56 69 105458 31157 110452615
Iron deficiency 18.72 9.56 49 105478 18427 110465345
Intracranial hypotension 18.60 9.56 10 105517 628 110483144
Sinus bradycardia 18.42 9.56 66 105461 29417 110454355
Behaviour disorder 18.34 9.56 33 105494 9614 110474158
Bundle branch block left 18.31 9.56 39 105488 12849 110470923
Intentional product use issue 18.26 9.56 150 105377 247756 110236016
Vaginal abscess 18.03 9.56 9 105518 484 110483288
Appendicitis 18.02 9.56 64 105463 28400 110455372
Respiratory tract infection viral 17.97 9.56 25 105502 5853 110477919
Product preparation error 17.92 9.56 35 105492 10844 110472928
Leukopenia 17.89 9.56 77 105450 148714 110335058
Corneal abrasion 17.84 9.56 13 105514 1396 110482376
Insomnia 17.68 9.56 240 105287 360350 110123422
Tenderness 17.63 9.56 65 105462 29372 110454400
Tremor 17.61 9.56 281 105246 201951 110281821
Pancreatitis acute 17.48 9.56 19 105508 60255 110423517
Taste disorder 17.47 9.56 22 105505 65365 110418407
Vocal cord dysfunction 17.36 9.56 11 105516 939 110482833
Intentional self-injury 17.31 9.56 7 105520 37422 110446350
Restlessness 17.17 9.56 102 105425 56157 110427615
Seizure like phenomena 17.16 9.56 16 105511 2425 110481347
Erythema 17.09 9.56 381 105146 291066 110192706
Fatigue 17.07 9.56 968 104559 1214990 109268782
Nail bed tenderness 17.03 9.56 8 105519 376 110483396
Anaphylactoid shock 16.99 9.56 11 105516 975 110482797
Orthostatic hypotension 16.97 9.56 23 105504 66226 110417546
Spinal meningeal cyst 16.96 9.56 6 105521 134 110483638
Diplopia 16.90 9.56 82 105445 41812 110441960
Anterior chamber fibrin 16.89 9.56 7 105520 243 110483529
Renal failure 16.89 9.56 307 105220 226267 110257505
Anal skin tags 16.88 9.56 9 105518 556 110483216
Heparin-induced thrombocytopenia 16.73 9.56 35 105492 11389 110472383
Onychomycosis 16.57 9.56 8 105519 38523 110445249
Phrenic nerve paralysis 16.55 9.56 9 105518 578 110483194
Bacteroides infection 16.54 9.56 17 105510 2902 110480870
Hypoxic-ischaemic encephalopathy 16.48 9.56 30 105497 8817 110474955
Respiratory acidosis 16.47 9.56 39 105488 13787 110469985
Quadriplegia 16.44 9.56 20 105507 4107 110479665
Economic problem 16.43 9.56 20 105507 4111 110479661
Oxygen saturation decreased 16.36 9.56 225 105302 156757 110327015
Enterobacter pneumonia 16.30 9.56 9 105518 596 110483176
Drug hypersensitivity 16.25 9.56 557 104970 453533 110030239
Diabetic ketoacidosis 16.24 9.56 10 105517 42048 110441724
Thrombocytopenia 16.11 9.56 235 105292 348650 110135122
Injection site joint infection 16.05 9.56 5 105522 74 110483698
Back injury 16.03 9.56 13 105514 47386 110436386
Laryngospasm 16.02 9.56 21 105506 4647 110479125
Spinal cord injury 15.92 9.56 13 105514 1652 110482120
Vitamin D increased 15.90 9.56 10 105517 843 110482929
Therapeutic product effect incomplete 15.77 9.56 137 105390 223668 110260104
Anaesthetic complication pulmonary 15.56 9.56 6 105521 172 110483600
Autoimmune disorder 15.53 9.56 24 105503 65459 110418313
Streptococcal infection 15.53 9.56 33 105494 10857 110472915
Infection susceptibility increased 15.43 9.56 20 105507 4378 110479394
Spinal cord oedema 15.37 9.56 8 105519 470 110483302
Reperfusion arrhythmia 15.36 9.56 7 105520 307 110483465
Airway complication of anaesthesia 15.27 9.56 9 105518 675 110483097
Sensory loss 15.12 9.56 50 105477 21407 110462365
Exostosis 15.05 9.56 13 105514 45943 110437829
Hypercapnia 14.98 9.56 33 105494 11126 110472646
Ventricular arrhythmia 14.89 9.56 31 105496 10056 110473716
Encephalopathy 14.86 9.56 130 105397 80925 110402847
Implant site bruising 14.85 9.56 7 105520 332 110483440
Catecholamine crisis 14.84 9.56 5 105522 96 110483676
Pruritus 14.82 9.56 432 105095 581128 109902644
Infusion site discomfort 14.80 9.56 13 105514 1824 110481948
Aortic stenosis 14.66 9.56 36 105491 13023 110470749
Kidney congestion 14.61 9.56 8 105519 521 110483251
Anal ulcer 14.57 9.56 13 105514 1863 110481909
Ventricular tachyarrhythmia 14.55 9.56 8 105519 525 110483247
Application site alopecia 14.55 9.56 4 105523 37 110483735
Cholestasis of pregnancy 14.51 9.56 11 105516 1254 110482518
Familial periodic paralysis 14.46 9.56 7 105520 352 110483420
Eyelid contusion 14.42 9.56 5 105522 105 110483667
Left ventricle outflow tract obstruction 14.41 9.56 8 105519 535 110483237
Hypoaesthesia 14.38 9.56 212 105315 314011 110169761
Total lung capacity decreased 14.38 9.56 25 105502 7089 110476683
Agitation 14.31 9.56 168 105359 112883 110370889
Glucose tolerance impaired 14.25 9.56 30 105497 9807 110473965
Eclampsia 14.23 9.56 7 105520 365 110483407
Vascular stenosis 14.20 9.56 9 105518 769 110483003
Chorioretinopathy 14.16 9.56 14 105513 2281 110481491
Memory impairment 14.12 9.56 120 105407 196824 110286948
Retrograde amnesia 14.10 9.56 9 105518 778 110482994
Iron binding capacity total decreased 14.09 9.56 8 105519 559 110483213
Product distribution issue 14.07 9.56 19 105508 4327 110479445
Repetitive strain injury 14.02 9.56 6 105521 226 110483546
Disseminated intravascular coagulation 14.00 9.56 77 105450 41209 110442563
Infusion site rash 13.92 9.56 14 105513 2329 110481443
Vitreous disorder 13.90 9.56 7 105520 384 110483388
Vision blurred 13.88 9.56 186 105341 128836 110354936
Liver function test abnormal 13.88 9.56 28 105499 68922 110414850
Ear infection 13.87 9.56 105 105422 62627 110421145
Apnoeic attack 13.85 9.56 9 105518 803 110482969
Infusion site streaking 13.80 9.56 8 105519 582 110483190
Ventricular hypokinesia 13.76 9.56 32 105495 11182 110472590
Heliotrope rash 13.73 9.56 6 105521 238 110483534
Spinal cord ischaemia 13.73 9.56 6 105521 238 110483534
Blood pressure fluctuation 13.73 9.56 32 105495 74792 110408980
Monoplegia 13.72 9.56 20 105507 4889 110478883
Nail bed inflammation 13.69 9.56 13 105514 2017 110481755
Product administered at inappropriate site 13.68 9.56 21 105506 5372 110478400
Normal newborn 13.66 9.56 49 105478 21847 110461925
Administration site pain 13.66 9.56 9 105518 822 110482950
Bronchitis 13.59 9.56 218 105309 156814 110326958
Procedural haemorrhage 13.58 9.56 21 105506 5406 110478366
C-reactive protein 13.50 9.56 6 105521 30325 110453447
Axillary nerve injury 13.46 9.56 4 105523 50 110483722
Abortion spontaneous 13.45 9.56 8 105519 34274 110449498
Atrioventricular block complete 13.45 9.56 46 105481 20036 110463736
Depressed level of consciousness 13.41 9.56 165 105362 112113 110371659
Application site pain 13.37 9.56 21 105506 5478 110478294
Blood uric acid increased 13.28 9.56 48 105479 21481 110462291
Ventricular asystole 13.28 9.56 7 105520 422 110483350
Air embolism 13.19 9.56 8 105519 632 110483140
Body dysmorphic disorder 13.19 9.56 7 105520 428 110483344
Irregular breathing 13.18 9.56 8 105519 633 110483139
Discomfort 13.17 9.56 136 105391 214571 110269201
Harlequin syndrome 13.12 9.56 6 105521 265 110483507
Infection 13.12 9.56 255 105272 361945 110121827
Acute kidney injury 13.11 9.56 485 105042 634945 109848827
Lung opacity 12.95 9.56 32 105495 11620 110472152
Viral infection 12.93 9.56 91 105436 53048 110430724
Sciatica 12.91 9.56 45 105482 92354 110391418
Encephalomalacia 12.85 9.56 11 105516 1491 110482281
Glossoptosis 12.84 9.56 6 105521 279 110483493
Cystic fibrosis 12.82 9.56 19 105508 4712 110479060
Allergy to immunoglobulin therapy 12.78 9.56 5 105522 149 110483623
Pancytopenia 12.77 9.56 133 105394 209480 110274292
Myokymia 12.72 9.56 5 105522 151 110483621
Colitis ulcerative 12.71 9.56 35 105492 77328 110406444
Accelerated idioventricular rhythm 12.70 9.56 6 105521 286 110483486
Oxidative stress 12.67 9.56 4 105523 62 110483710
Laboratory test abnormal 12.66 9.56 14 105513 44065 110439707
Nasal mucosal disorder 12.58 9.56 12 105515 1871 110481901
Spinal stroke 12.55 9.56 4 105523 64 110483708
Serotonin syndrome 12.52 9.56 98 105429 59055 110424717
Conjunctival oedema 12.51 9.56 11 105516 1545 110482227
Kidney infection 12.49 9.56 53 105474 25546 110458226
Exophthalmos 12.45 9.56 13 105514 2260 110481512
Premature baby 12.45 9.56 19 105508 4836 110478936
Cough 12.44 9.56 549 104978 461092 110022680
Pseudomonas infection 12.32 9.56 56 105471 27797 110455975
Gastrooesophageal reflux disease 12.31 9.56 111 105416 179865 110303907
Femoral nerve injury 12.27 9.56 4 105523 69 110483703
Depression 12.24 9.56 221 105306 317114 110166658
Disease recurrence 11.97 9.56 25 105502 60759 110423013
Acute respiratory failure 11.93 9.56 117 105410 75143 110408629
Uveitis 11.92 9.56 3 105524 21707 110462065
Prostate cancer 11.90 9.56 11 105516 37630 110446142
Blood pressure systolic increased 11.88 9.56 40 105487 82951 110400821
Infective pulmonary exacerbation of cystic fibrosis 11.86 9.56 36 105491 14735 110469037
Lethargy 11.82 9.56 139 105388 93437 110390335
Lung neoplasm malignant 11.80 9.56 9 105518 33833 110449939
Orbital infection 11.79 9.56 5 105522 184 110483588
Allergy to arthropod sting 11.73 9.56 6 105521 340 110483432
Opisthotonus 11.69 9.56 8 105519 778 110482994
Transferrin decreased 11.68 9.56 7 105520 541 110483231
Postictal state 11.66 9.56 13 105514 2433 110481339
Brain herniation 11.66 9.56 26 105501 8837 110474935
Nerve block 11.66 9.56 8 105519 781 110482991
Calcinosis 11.65 9.56 14 105513 2838 110480934
Allodynia 11.56 9.56 12 105515 2071 110481701
Myotonic dystrophy 11.54 9.56 5 105522 194 110483578
Atelectasis 11.48 9.56 67 105460 36645 110447127
Quadriparesis 11.48 9.56 18 105509 4689 110479083
Activated partial thromboplastin time prolonged 11.45 9.56 47 105480 22321 110461451
Drug tolerance decreased 11.42 9.56 6 105521 27534 110456238
Palpitations 11.42 9.56 97 105430 159115 110324657
Malignant neoplasm progression 11.36 9.56 109 105418 174458 110309314
Obstruction 11.35 9.56 20 105507 5732 110478040
Arthritis bacterial 11.28 9.56 29 105498 10791 110472981
Arthritis fungal 11.26 9.56 5 105522 206 110483566
Intentional product misuse to child 11.24 9.56 5 105522 207 110483565
Vitreous floaters 11.13 9.56 26 105501 9108 110474664
Jaundice 11.13 9.56 25 105502 59211 110424561
End-tidal CO2 decreased 11.12 9.56 4 105523 94 110483678
Product prescribing error 11.07 9.56 20 105507 51311 110432461
Incontinence 11.05 9.56 38 105489 16597 110467175
Anticoagulant therapy 11.05 9.56 19 105508 5342 110478430
Intraocular pressure fluctuation 11.04 9.56 4 105523 96 110483676
Procedural anxiety 11.03 9.56 8 105519 853 110482919
Progressive multifocal leukoencephalopathy 11.01 9.56 5 105522 24951 110458821
Cytokine release syndrome 11.00 9.56 109 105418 70197 110413575
Hypoventilation 10.96 9.56 24 105503 8057 110475715
Hyperlipidaemia 10.94 9.56 65 105462 35783 110447989
Mucosal disorder 10.92 9.56 17 105510 4400 110479372
Dyspepsia 10.90 9.56 123 105404 190842 110292930
Victim of chemical submission 10.88 9.56 8 105519 871 110482901
Meningitis 10.82 9.56 30 105497 11672 110472100
Pneumonia 10.81 9.56 974 104553 875740 109608032
Retinal detachment 10.80 9.56 29 105498 11071 110472701
Dystonia 10.76 9.56 51 105476 25754 110458018
Injection site reaction 10.76 9.56 46 105481 89024 110394748
Antacid therapy 10.73 9.56 19 105508 5465 110478307
Neuroleptic malignant syndrome 10.72 9.56 10 105517 34049 110449723
Anaesthetic complication cardiac 10.70 9.56 4 105523 105 110483667
Hepatocellular injury 10.68 9.56 20 105507 50622 110433150
Diplegia 10.66 9.56 12 105515 2269 110481503
Dysarthria 10.64 9.56 125 105402 83996 110399776
Melaena 10.64 9.56 32 105495 68725 110415047
Thrombosis 10.62 9.56 154 105373 108508 110375264
Hypoglycaemia 10.61 9.56 66 105461 116038 110367734
Deafness bilateral 10.60 9.56 13 105514 2691 110481081
Intercepted medication error 10.60 9.56 9 105518 1207 110482565
Acute pulmonary oedema 10.58 9.56 38 105489 16958 110466814
Dermatitis diaper 10.56 9.56 6 105521 420 110483352
Dry mouth 10.56 9.56 131 105396 199817 110283955
Lymphatic disorder 10.49 9.56 6 105521 425 110483347
Engraftment syndrome 10.49 9.56 11 105516 1921 110481851
Injury 10.47 9.56 232 105295 177033 110306739
Sympathectomy 10.44 9.56 3 105524 33 110483739
Coccygectomy 10.44 9.56 3 105524 33 110483739
Oesophageal obstruction 10.43 9.56 9 105518 1234 110482538
Infusion site nodule 10.42 9.56 6 105521 431 110483341
Brugada syndrome 10.39 9.56 10 105517 1578 110482194
Amaurosis 10.38 9.56 10 105517 1579 110482193
Corneal opacity 10.38 9.56 9 105518 1242 110482530
Injection site joint swelling 10.36 9.56 3 105524 34 110483738
Vasospasm 10.34 9.56 10 105517 1586 110482186
Poor quality product administered 10.30 9.56 17 105510 4624 110479148
Mean arterial pressure increased 10.30 9.56 4 105523 117 110483655
Diabetes mellitus inadequate control 10.28 9.56 8 105519 29767 110454005
Full blood count abnormal 10.26 9.56 24 105503 56028 110427744
Slow response to stimuli 10.23 9.56 11 105516 1977 110481795
Hypercalcaemia 10.22 9.56 18 105509 46639 110437133
Blood pH decreased 10.22 9.56 17 105510 4652 110479120
Cancer pain 10.21 9.56 21 105506 6751 110477021
Induration 10.21 9.56 12 105515 2377 110481395
Cellulitis 10.19 9.56 173 105354 125843 110357929
Ingrowing nail 10.16 9.56 14 105513 3248 110480524
Vascular resistance systemic decreased 10.16 9.56 5 105522 261 110483511
Adverse reaction 10.15 9.56 8 105519 29586 110454186
Tinnitus 10.03 9.56 95 105432 60445 110423327
Thyrotoxic crisis 10.00 9.56 11 105516 2029 110481743
Sinusitis bacterial 9.99 9.56 12 105515 2432 110481340
Incision site rash 9.99 9.56 3 105524 39 110483733
Fear of death 9.98 9.56 10 105517 1657 110482115
Haemorrhagic vasculitis 9.93 9.56 4 105523 129 110483643
Foreign body sensation in eyes 9.93 9.56 14 105513 3320 110480452
Treatment noncompliance 9.90 9.56 36 105491 72954 110410818
Decubitus ulcer 9.88 9.56 39 105488 18197 110465575
Varicose vein 9.86 9.56 21 105506 6919 110476853
Syringomyelia 9.81 9.56 5 105522 281 110483491
Pupil fixed 9.81 9.56 15 105512 3823 110479949
Angioedema 9.78 9.56 140 105387 98360 110385412
Symblepharon 9.76 9.56 6 105521 486 110483286
Poikiloderma 9.76 9.56 6 105521 486 110483286
Oedema peripheral 9.71 9.56 239 105288 328421 110155351
Injection site atrophy 9.68 9.56 6 105521 493 110483279
Muscle strain 9.65 9.56 28 105499 11174 110472598
Tracheal deviation 9.62 9.56 5 105522 293 110483479
Blindness transient 9.62 9.56 19 105508 5937 110477835
Pneumonia mycoplasmal 9.61 9.56 10 105517 1731 110482041

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AA05 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC J01XB02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Polymyxins
ATC S01AA18 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
ATC S02AA11 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA03 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
FDA CS M0017217 Polymyxins
FDA EPC N0000175499 Polymyxin-class Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

A07AA Antibiotics 12 drugs
amphotericin Bcolistinfidaxomicinkanamycinnatamycinneomycinnystatinparomomycinrifamycinrifaximinstreptomycinvancomycin
J01XB Polymyxins 1 drug
colistin
S01AA Antibiotics 27 drugs
amikacinampicillinazidamfenicolazithromycinbacitracinbenzylpenicillincefmenoximecefuroximechloramphenicolchlortetracyclinedibekacindihydrostreptomycin show all 27 →
S02AA Antiinfectives 17 drugs
acetic acidaluminium acetotartrateboric acidcefmenoximechloramphenicolchlorhexidineciprofloxacinclioquinolfosfomycingentamicinhydrogen peroxidemiconazole show all 17 →
S03AA Antiinfectives 7 drugs
chloramphenicolchlorhexidineciprofloxacingentamicinhexamidineneomycintetracycline

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Bacterial septicemia indication 10001005 DOID:0040085
Urinary tract infectious disease indication 68566005
Blepharoconjunctivitis indication 68659002 DOID:2456
Corneal abrasion indication 85848002
Bacterial conjunctivitis indication 128350005 DOID:9700
Uveitis indication 128473001 DOID:13141
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Superficial Ocular Infection indication
Minor Bacterial Skin Infections indication
Minor Skin Wound Pain indication
Mastoidectomy Cavity Infections indication
H. Influenzae Meningitis indication
Chronic purulent otitis media off-label use 38394007 DOID:14247
Dacryocystitis off-label use 85777005 DOID:9938
Corneal ulcer off-label use 91514001 DOID:8463
Meibomianitis off-label use 309779001
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Herpes zoster auricularis contraindication 21954000 DOID:9210
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Bullous myringitis contraindication 33528003 DOID:13791
Dehydration contraindication 34095006
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Neuromuscular block, function contraindication 55394004
Perforation of tympanic membrane contraindication 60442001
Diabetes mellitus contraindication 73211009 DOID:9351
Third degree burn injury contraindication 80247002
Oliguria contraindication 83128009
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Procedure on urinary system contraindication 118677009
Open wound contraindication 125643001
Eye infection contraindication 128351009
Hearing disorder contraindication 128540005
Bacterial infection of eye contraindication 128984004
Tuberculosis of ear contraindication 186269001
Telangiectasia disorder contraindication 247479008
Rupture of bladder contraindication 251925007
Injury of eye region contraindication 282752000
Pregnancy, function contraindication 289908002
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Vaccinia keratitis contraindication 397552005
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation associated with topical ophthalmological conditions of the eye Indication
Cats Edema associated with topical ophthalmological conditions of the eye Indication
Cats Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Cattle Superficial ocular infections Indication
Cattle Infections caused by streptococci Indication
Cattle Infections caused by rickettsiae Indication
Cattle Infections caused by Escherichia coli Indication
Cattle Infections caused by A aerogenes Indication
Dogs Inflammation associated with topical ophthalmological conditions of the eye Indication
Dogs Edema associated with topical ophthalmological conditions of the eye Indication
Dogs Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Horses Inflammation associated with topical ophthalmological conditions of the eye Indication
Horses Edema associated with topical ophthalmological conditions of the eye Indication
Horses Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication
Sheep Inflammation associated with topical ophthalmological conditions of the eye Indication
Sheep Edema associated with topical ophthalmological conditions of the eye Indication
Sheep Secondary bacterial infections associated with topical ophthalmological conditions of the eye Indication

🐶 Veterinary products

ProductApplicantIngredients
Terramycin Ophthalmic Ointment with Polymyxin Zoetis Inc. 2
Anaprime Ophthalmic Solution Zoetis Inc. 3
Anaprime Opthakote Ophthalmic Zoetis Inc. 3
Optiprime Opthakote Ophthalmic Solution Zoetis Inc. 2
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment Dechra, Ltd. 4
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment Dechra, Ltd. 3
Mycitracin Sterile Ophthalmic Ointment Zoetis Inc. 3
Forte Topical Ointment Zoetis Inc. 4
Cortisporin Veterinary Ophthalmic Ointment Intervet Inc. 4
Neosporin Ophthalmic Ointment Intervet Inc. 3
Surolan Elanco US Inc. 3
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment Akorn Animal Health Inc. 3

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018100 VUID
N0000146438 NUI
D08401 KEGG_DRUG
1404-26-8 SECONDARY_CAS_RN
4018100 VANDF
4018594 VANDF
C0032535 UMLSCUI
CHEBI:759086 CHEBI
CHEMBL5314354 ChEMBL_ID
CHEMBL5314355 ChEMBL_ID
D011112 MESH_DESCRIPTOR_UI
DB00781 DRUGBANK_ID
10338 IUPHAR_LIGAND_ID
490 INN_ID
J2VZ07J96K UNII
202404 RXNORM
1703 MMSL
5317 MMSL
5318 MMSL
d00344 MMSL
002803 NDDF
004902 NDDF
372824005 SNOMEDCT_US
61360007 SNOMEDCT_US
6960003 SNOMEDCT_US
5702105 PUBCHEM_CID
J2VZ07J96K INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MAXITROL HUMAN PRESCRIPTION DRUG LABEL 3 0078-0771 OINTMENT 10000 [USPU] OPHTHALMIC NDA 18 sections
Good Sense First Aid Antibiotic HUMAN OTC DRUG LABEL 3 0113-0084 OINTMENT 5000 [USPU] TOPICAL OTC Monograph Drug 13 sections
Good Sense Triple Antibioticand Pain Relief HUMAN OTC DRUG LABEL 4 0113-0679 OINTMENT 10000 [USPU] TOPICAL OTC Monograph Drug 13 sections
good sense triple antibiotic HUMAN OTC DRUG LABEL 4 0113-1140 OINTMENT 10000 [USPU] TOPICAL OTC Monograph Drug 13 sections
Polymyxin B HUMAN PRESCRIPTION DRUG LABEL 1 0143-9461 INJECTION, POWDER, FOR SOLUTION 500000 [USPU] INTRAMUSCULAR ANDA 12 sections
Polymyxin B HUMAN PRESCRIPTION DRUG LABEL 1 0143-9941 INJECTION, POWDER, FOR SOLUTION 500000 [iU] INTRAMUSCULAR ANDA 14 sections
Bacitracin Zinc and Polymyxin B Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0168-0273 OINTMENT 10000 1 OPHTHALMIC ANDA 17 sections
AntibioticMaximum Strength HUMAN OTC DRUG LABEL 3 0363-0018 OINTMENT 10000 [iU] TOPICAL OTC Monograph Drug 13 sections
Triple Antibiotic with Pain ReliefMaximum Strength HUMAN OTC DRUG LABEL 4 0363-0123 OINTMENT 10000 [USPU] TOPICAL OTC MONOGRAPH FINAL 13 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 5000 [USPU] TOPICAL OTC Monograph Drug 14 sections
First Aid Antibiotic HUMAN OTC DRUG LABEL 4 0363-0841 OINTMENT 10000 [USPU] TOPICAL OTC Monograph Drug 13 sections
ANTIBIOTICMaximum Strength Human OTC Drug Label 3 0363-1331 OINTMENT 10000 [iU] TOPICAL OTC Monograph Drug 13 sections
triple antibiotic Human OTC Drug Label 3 0363-1332 OINTMENT 5000 [USPU] TOPICAL OTC Monograph Drug 13 sections
Walgreens Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-2016 OINTMENT 5000 [iU] TOPICAL OTC MONOGRAPH FINAL 14 sections
Walgreens Kids Multi-Antibiotic with Pain Relief Cream HUMAN OTC DRUG LABEL 3 0363-2122 CREAM 10000 [USPU] TOPICAL OTC Monograph Drug 11 sections
Walgreens Multi-Antibiotic with Pain Relief Cream HUMAN OTC DRUG LABEL 3 0363-2123 CREAM 10000 [USPU] TOPICAL OTC Monograph Drug 9 sections
triple antibiotic pain relief HUMAN OTC DRUG LABEL 4 0363-6790 OINTMENT 10000 [USPU] TOPICAL OTC Monograph Drug 13 sections
Walgreens Maximum Strength Triple Antibiotic With Pain Relief HUMAN OTC DRUG LABEL 4 0363-7872 OINTMENT 1000 [USPU] TOPICAL OTC monograph final 11 sections
Walgreens Wal-Sporin First Aid Antibiotic HUMAN OTC DRUG LABEL 2 0363-8821 OINTMENT 10000 [USPU] TOPICAL OTC monograph final 12 sections
Triple Antibiotic Plus Pain Relief HUMAN OTC DRUG LABEL 4 0363-8888 OINTMENT 10000 [USPU] TOPICAL OTC Monograph Drug 14 sections
Bacitracin Zinc, Neomycin Sulfate, and Polymyxin B Sulfate HUMAN OTC DRUG LABEL 3 0404-0167 OINTMENT 5000 [iU] TOPICAL OTC Monograph Drug 12 sections
Bacitracin Zinc, Polymyxin B Sulfate, and Neomycin Sulfate HUMAN OTC DRUG LABEL 3 0404-0171 OINTMENT 50000 [iU] TOPICAL OTC Monograph Drug 12 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0713-0268 OINTMENT 5000 [USPU] TOPICAL OTC Monograph Drug 9 sections
Triple Antibiotic Plus HUMAN OTC DRUG LABEL 4 0713-0622 OINTMENT 10000 [USPU] TOPICAL OTC Monograph Drug 9 sections
Major Triple Antibiotic HUMAN OTC DRUG LABEL 3 0904-8805 OINTMENT 5000 [USPU] TOPICAL OTC Monograph Drug 15 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0924-5603 OINTMENT 5000 [iU] TOPICAL OTC monograph final 11 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0924-5603 OINTMENT 5000 [iU] TOPICAL OTC monograph final 11 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0924-5603 OINTMENT 5000 [iU] TOPICAL OTC monograph final 11 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0924-5604 OINTMENT 5000 [iU] TOPICAL OTC Monograph Drug 12 sections
First Aid Only Triple Antibiotic HUMAN OTC DRUG LABEL 3 0924-5605 OINTMENT 5322.80 [iU] TOPICAL OTC monograph final 12 sections