DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
esatenolol 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
beta-adrenoreceptor antagonists
4702
93379-54-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
s-atenolol
(-)-Atenolol
(S)-Atenolol
esatenolol
Molecular weight: 266.34
Formula: C14H22N2O3
CLOGP: -0.11
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 84.58
ALOGS: -2.79
ROTB: 8
Drug dosage:
Dose
Unit
Route
50
mg
O
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C07AB11
CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
CHEBI has role
CHEBI:35530
beta-adrenergic blockers
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
12.92
acidic
pKa2
9.19
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Beta-1 adrenergic receptor
GPCR
P08588
ADRB1_HUMAN
Ki
6.82
CHEMBL
Beta-2 adrenergic receptor
GPCR
P07550
ADRB2_HUMAN
Ki
5
CHEMBL
Adenosine receptor A3
GPCR
P0DMS8
AA3R_HUMAN
IC50
8.75
CHEMBL
5-hydroxytryptamine receptor 1A
GPCR
5HT1A_RAT
Ki
5
CHEMBL
Beta-2 adrenergic receptor
GPCR
ADRB2_CAVPO
Kd
5.93
CHEMBL
Beta-1 adrenergic receptor
GPCR
B0FL73_CAVPO
Kd
7.62
CHEMBL
Urease
Enzyme
UREA_CANEN
IC50
4.19
CHEMBL
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External reference:
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entries
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ID
Source
175540
PUBCHEM_CID
7337
INN_ID
C3652674
UMLSCUI
CHEBI:31556
CHEBI
CHEMBL24
ChEMBL_ID
CHEMBL343633
ChEMBL_ID
D01471
KEGG_DRUG
DB13443
DRUGBANK_ID
DPF757BOSR
UNII
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Pharmaceutical products:
None
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esatenolol