practolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 3486 6673-35-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • practolol
  • (+/-)-Practolol
  • eraldin
  • teranol
  • dl-Practolol
A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.
  • Molecular weight: 266.34
  • Formula: C14H22N2O3
  • CLOGP: 0.75
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 70.59
  • ALOGS: -2.74
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.30 g O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 2.28 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.93 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AB01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35530 beta-adrenoceptor antagonists
CHEBI has role CHEBI:38070 antiarrhythmic agent

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 6.80 IUPHAR IUPHAR
Beta-2 adrenergic receptor GPCR Kd 4.69 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 6.47 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.80 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 6.98 CHEMBL
Beta-2 adrenergic receptor Unclassified Ki 4.87 CHEMBL

External reference:

IDSource
N0000166900 NUI
D05587 KEGG_DRUG
C1263552 UMLSCUI
CHEBI:258351 CHEBI
4883 PUBCHEM_CID
CHEMBL6995 ChEMBL_ID
D011217 MESH_DESCRIPTOR_UI
DB01297 DRUGBANK_ID
555 IUPHAR_LIGAND_ID
2832 INN_ID
SUG9176GRW UNII
386156 RXNORM
003757 NDDF
387436006 SNOMEDCT_US
76390000 SNOMEDCT_US

Pharmaceutical products:

None