practolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 3486 6673-35-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • practolol
  • (+/-)-Practolol
  • eraldin
  • teranol
  • dl-Practolol
A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.
  • Molecular weight: 266.34
  • Formula: C14H22N2O3
  • CLOGP: 0.75
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 70.59
  • ALOGS: -2.74
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.30 g O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 2.28 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.93 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AB01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
CHEBI has role CHEBI:35530 beta-adrenergic antagonist
CHEBI has role CHEBI:38070 anti-arrhythmia drug
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 6.80 IUPHAR IUPHAR
Beta-2 adrenergic receptor GPCR Kd 4.69 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 6.47 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.80 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 6.98 CHEMBL
Beta-2 adrenergic receptor Unclassified Ki 4.87 CHEMBL

External reference:

IDSource
N0000166900 NUI
C0032896 UMLSCUI
D05587 KEGG_DRUG
76390000 SNOMEDCT_US
8620 RXNORM
387436006 SNOMEDCT_US
003757 NDDF
CHEBI:258351 CHEBI
CHEMBL6995 ChEMBL_ID
SUG9176GRW UNII
2832 INN_ID
DB01297 DRUGBANK_ID
4883 PUBCHEM_CID
D011217 MESH_DESCRIPTOR_UI
555 IUPHAR_LIGAND_ID

Pharmaceutical products:

None