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practolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| beta-adrenoreceptor antagonists | 3486 | 6673-35-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | O |
| 20 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| CL (Clearance) | 2.28 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.93 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 12.20 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 0.49 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -1.331 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.274 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 0.800 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.256 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 90.540 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 82.150 | % | High | 1 |
| herg | hERG pIC50 | 4.185 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.189 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.083 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 88.230 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 45 | |||
| kinase-selectivity-class | AXL,CDK4,EIF2AK3,GRK2,PDK4,STK33,TEK | 7 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.517 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 2.223 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 93.260 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 1.932 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 94.810 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 0.971 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 87.970 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 92.470 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 914.113 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C07AB01 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, selective |
| MeSH PA | D000319 | Adrenergic beta-Antagonists |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018674 | Adrenergic Antagonists |
| MeSH PA | D058671 | Adrenergic beta-1 Receptor Antagonists |
| CHEBI has role | CHEBI:35530 | β-adrenergic antagonist |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:38070 | anti-arrhythmia drug |
Related Drugs by ATC class:
C07AB Beta blocking agents, selective 13 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 6.80 | IUPHAR | IUPHAR | |||
| Beta-2 adrenergic receptor | GPCR | Kd | 5.80 | CHEMBL | |||||
| Beta-2 adrenergic receptor | GPCR | Kd | 4.69 | CHEMBL | |||||
| Beta-1 adrenergic receptor | GPCR | Kd | 6.47 | CHEMBL | |||||
| Beta-1 adrenergic receptor | GPCR | Kd | 6.98 | CHEMBL | |||||
| Beta-2 adrenergic receptor | GPCR | Ki | 4.87 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166900 | NUI |
| D05587 | KEGG_DRUG |
| C0032896 | UMLSCUI |
| CHEBI:258351 | CHEBI |
| CHEMBL6995 | ChEMBL_ID |
| DB01297 | DRUGBANK_ID |
| D011217 | MESH_DESCRIPTOR_UI |
| 4883 | PUBCHEM_CID |
| 555 | IUPHAR_LIGAND_ID |
| 2832 | INN_ID |
| SUG9176GRW | UNII |
| 386156 | RXNORM |
| 003757 | NDDF |
| 387436006 | SNOMEDCT_US |
| 76390000 | SNOMEDCT_US |
| SUG9176GRW | INXIGHT DRUGS |
Pharmaceutical products:
None