desoximetasone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	819	382-67-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: desoximetasone deoxymethasone desoximethasone desoxymetasone desoxymethasone	A topical anti-inflammatory glucocorticoid used in DERMATOSES, skin allergies, PSORIASIS, etc. Molecular weight: 376.47 Formula: C22H29FO4 CLOGP: 2.41 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 74.60 ALOGS: -4.08 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

desoximetasone
deoxymethasone
desoximethasone
desoxymetasone
desoxymethasone

A topical anti-inflammatory glucocorticoid used in DERMATOSES, skin allergies, PSORIASIS, etc.

Molecular weight: 376.47
Formula: C22H29FO4
CLOGP: 2.41
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 74.60
ALOGS: -4.08
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 28, 1977	FDA	TARO PHARMS NORTH

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	4352.30	54.43	3830	176733	179896	63128563
Glossodynia	4108.75	54.43	3665	176898	175211	63133248
Systemic lupus erythematosus	3932.38	54.43	3831	176732	205087	63103372
Hand deformity	3570.49	54.43	3222	177341	156235	63152224
Wound	3062.73	54.43	2991	177572	160272	63148187
Alopecia	2876.99	54.43	4125	176438	333411	62975048
Pericarditis	2665.49	54.43	2516	178047	129063	63179396
Arthropathy	2654.89	54.43	3297	177266	231495	63076964
Discomfort	2620.41	54.43	2782	177781	164592	63143867
Abdominal discomfort	2582.49	54.43	3818	176745	317067	62991392

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Bone cyst	296.91	33.75	74	10796	1526	34944535
Onychoclasis	260.27	33.75	69	10801	1831	34944230
Drug ineffective	246.95	33.75	476	10394	456275	34489786
Bone erosion	229.57	33.75	74	10796	3941	34942120
Lymphoma	229.02	33.75	100	10770	12407	34933654
Synovitis	227.21	33.75	103	10767	13963	34932098
Drug intolerance	224.21	33.75	169	10701	59401	34886660
Anti-cyclic citrullinated peptide antibody positive	210.52	33.75	58	10812	1785	34944276
Joint ankylosis	205.40	33.75	55	10815	1517	34944544
Tooth loss	203.92	33.75	67	10803	3791	34942270

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	3220.15	44.20	2058	136754	97524	79508052
Systemic lupus erythematosus	2943.48	44.20	2097	136715	119052	79486524
Glossodynia	2895.85	44.20	1953	136859	101384	79504192
Hand deformity	2859.60	44.20	1942	136870	101977	79503599
Synovitis	2552.85	44.20	2105	136707	148629	79456947
Anti-cyclic citrullinated peptide antibody positive	2360.91	44.20	1585	137227	81558	79524018
Pericarditis	2352.09	44.20	1726	137086	102510	79503066
Alopecia	2254.50	44.20	2374	136438	228981	79376595
Wound	2219.98	44.20	1742	137070	114437	79491139
Arthropathy	2052.69	44.20	1997	136815	175114	79430462

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D07AC03	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III)
ATC	D07XC02	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, potent, other combinations
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:59683	antipruritic drugs
FDA EPC	N0000175576	Corticosteroid
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Atopic dermatitis	indication	24079001	DOID:3310
Contact dermatitis	indication	40275004	DOID:2773
Seborrheic dermatitis	indication	50563003	DOID:8741
Lichen simplex chronicus	indication	53891004
Granuloma annulare	indication	65508009	DOID:3777
Pruritus ani	indication	90446007
Discoid lupus erythematosus	indication	200938002
Plaque psoriasis	indication	200965009
Scalp psoriasis	indication	238608008
Pruritus of genital organs	indication	267802000

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.54	acidic
pKa2	12.99	acidic

Orange Book patent data (new drug applications)

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Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.25%	TOPICORT	TARO PHARMS	N204141	April 11, 2013	RX	SPRAY	TOPICAL	8715624	May 26, 2026	TREATMENT OF PLAQUE PSORIASIS IN PATIENTS 18 YEARS OF AGE OR OLDER
0.25%	TOPICORT	TARO PHARMS	N204141	April 11, 2013	RX	SPRAY	TOPICAL	8277780	Sept. 1, 2028	TREATMENT OF PLAQUE PSORIASIS IN PATIENTS 18 YEARS OF AGE OR OLDER

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Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	Ki	8.93	DRUG MATRIX	CHEMBL
Annexin A1	Cytosolic other	P04083	ANXA1_HUMAN				WOMBAT-PK
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	7.96	DRUG MATRIX

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External reference:

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ID	Source
002180	NDDF
1103	MMSL
2467	INN_ID
3255	RXNORM
387473009	SNOMEDCT_US
4018465	VUID
4018465	VANDF
4551	MMSL
4E07GXB7AU	UNII
5311067	PUBCHEM_CID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0151	OINTMENT	2.50 mg	TOPICAL	ANDA	20 sections
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0180	CREAM	2.50 mg	TOPICAL	ANDA	19 sections
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	0472-0478	CREAM	2.50 mg	TOPICAL	ANDA	14 sections
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	0472-0479	OINTMENT	2.50 mg	TOPICAL	ANDA	14 sections
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0657	OINTMENT	2.50 mg	TOPICAL	ANDA	14 sections
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	40032-024	OINTMENT	2.50 mg	TOPICAL	ANDA	11 sections
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	42254-015	CREAM	2.50 mg	TOPICAL	ANDA	23 sections
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	45802-495	CREAM	2.50 mg	TOPICAL	ANDA	22 sections
Desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	45802-495	CREAM	2.50 mg	TOPICAL	ANDA	22 sections
desoximetasone	HUMAN PRESCRIPTION DRUG LABEL	1	45802-496	OINTMENT	2.50 mg	TOPICAL	ANDA	22 sections

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