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diflorasone diacetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4485 | 33564-31-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
topical corticosteroid has anti-inflammatory, anti-pruritic, and vasoconstrictive actions
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK | 20 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 14, 1977 | FDA | PHARMACIA AND UPJOHN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AC10 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drug |
| CHEBI has role | CHEBI:59683 | antipruritic drug |
Related Drugs by ATC class:
D07AC Corticosteroids, potent (group III) 20 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Lichen simplex chronicus | indication | 53891004 | |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Pruritus ani | indication | 90446007 | |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Scalp psoriasis | indication | 238608008 | |
| Pruritus of genital organs | indication | 267802000 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Primary cutaneous T-cell lymphoma | indication | 400122007 | |
| Telangiectasia disorder | contraindication | 247479008 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.48 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 8.54 | DRUG MATRIX | CHEMBL | |||
| Progesterone receptor | Transcription factor | Ki | 7.82 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| D01327 | KEGG_DRUG |
| 4018081 | VUID |
| N0000179106 | NUI |
| 4018081 | VANDF |
| 4019719 | VANDF |
| CHEMBL1200545 | ChEMBL_ID |
| C014477 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7068 | IUPHAR_LIGAND_ID |
| DB00223 | DRUGBANK_ID |
| 23033 | RXNORM |
| 11711 | MMSL |
| 4594 | MMSL |
| 002201 | NDDF |
| 004950 | NDDF |
| 38446009 | SNOMEDCT_US |
| 772931004 | SNOMEDCT_US |
| 7924004 | SNOMEDCT_US |
| C0057992 | UMLSCUI |
| C0304612 | UMLSCUI |
| 71414 | PUBCHEM_CID |
| 2557-49-5 | SECONDARY_CAS_RN |
| 71415 | PUBCHEM_CID |
| 7W2J09SCWX | UNII |
| 3314 | INN_ID |
| T2DHJ9645W | UNII |
| CHEBI:59750 | CHEBI |
| 7W2J09SCWX | INXIGHT DRUGS |
| T2DHJ9645W | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Diflorasone Diacetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1295 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 21 sections |
| Diflorasone Diacetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1296 | CREAM | 0.50 mg | TOPICAL | ANDA | 21 sections |
| psorcon | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-5292 | CREAM | 5 mg | TOPICAL | ANDA | 21 sections |
| Diflorasone Diacetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-063 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 22 sections |
| Diflorasone Diacetate | Human Prescription Drug Label | 1 | 64980-124 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 17 sections |